Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:monomethoxybenzene
go back to main search page
Accession:CHEBI:25235 term browser browse the term
Definition:Compounds containing a benzene skeleton substituted with one methoxy group.
Synonyms:related_synonym: monomethoxybenzenes


show annotations for term's descendants           Sort by:
(+)-isolariciresinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnf1a HNF1 homeobox A decreases expression ISO isolariciresinol results in decreased expression of HNF1A mRNA CTD PMID:35755389 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO isolariciresinol results in decreased expression of LDLR protein CTD PMID:35755389 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression ISO isolariciresinol results in decreased expression of PCSK9 mRNA; isolariciresinol results in decreased expression of PCSK9 protein CTD PMID:35755389 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO isolariciresinol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21191767 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO isolariciresinol results in decreased expression of SREBF1 mRNA CTD PMID:35755389 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 decreases expression ISO isolariciresinol results in decreased expression of SREBF2 mRNA CTD PMID:35755389 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
(+)-pinoresinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases expression		 ISO [loliolide co-treated with pinoresinol] results in decreased expression of ACACA protein
pinoresinol results in decreased expression of ACACA protein		 CTD PMID:31610126 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases expression		 ISO [loliolide co-treated with pinoresinol] results in decreased expression of FASN protein
pinoresinol results in decreased expression of FASN protein		 CTD PMID:31610126 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO pinoresinol results in increased ubiquitination of and results in increased degradation of and results in decreased expression of NR1H2 protein CTD PMID:31610126 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO pinoresinol results in increased ubiquitination of and results in increased degradation of and results in decreased expression of NR1H3 protein CTD PMID:31610126 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pinoresinol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21191767 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
multiple interactions		 ISO pinoresinol results in decreased expression of SREBF1 protein
[loliolide co-treated with pinoresinol] results in decreased expression of SREBF1 protein		 CTD PMID:31610126 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO pinoresinol results in decreased secretion of TNF protein CTD PMID:29740324 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of AKT1 protein] CTD PMID:38521250 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of BAX protein CTD PMID:38521250 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of BCL2 protein CTD PMID:38521250 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP3 protein]		 CTD PMID:38521250 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP9 protein CTD PMID:38521250 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CCNB1 protein CTD PMID:38521250 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CDC25C protein CTD PMID:38521250 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CDK1 protein CTD PMID:38521250 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of CDKN1A protein CTD PMID:38521250 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of CDKN1B protein CTD PMID:38521250 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CYCS protein CTD PMID:38521250 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]		 CTD PMID:31029725 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA; 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein		 CTD PMID:31029725 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein] CTD PMID:31029725 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA] CTD PMID:31029725 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased lipidation of and results in increased localization of MAP1LC3B protein; Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased lipidation of and results in increased localization of MAP1LC3B protein] CTD PMID:38521250 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:31029725 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:31029725 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased phosphorylation of MAPK8 protein
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]		 CTD PMID:31029725 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of MTOR protein
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of MTOR protein]		 CTD PMID:38521250 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein]		 CTD PMID:31029725 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of and affects the stability of NFKBIA protein] CTD PMID:31029725 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA
NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]		 CTD PMID:31029725 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]		 CTD PMID:31029725 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of PARP1 protein] CTD PMID:38521250 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of PIK3R1 protein] CTD PMID:38521250 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of SQSTM1 protein CTD PMID:38521250 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA] CTD PMID:31029725 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
2-nitroanisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP 2-nitroanisole results in increased expression of ALDH1A1 protein CTD PMID:33211169 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Cd44 CD44 molecule increases expression EXP 2-nitroanisole results in increased expression of CD44 protein CTD PMID:33211169 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases oxidation
increases expression		 ISO
EXP		 CYP1A1 protein results in increased metabolism of 2-nitroanisole
CYP1A1 protein results in increased oxidation of 2-nitroanisole
2-nitroanisole results in increased expression of CYP1A1		 CTD PMID:11409192 PMID:15144223 PMID:17159769 PMID:21218109 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP 2-nitroanisole results in increased expression of CYP1A2; 2-nitroanisole results in increased expression of CYP1A2 protein CTD PMID:11409192 PMID:16601807 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases oxidation EXP CYP2B2 protein results in increased oxidation of 2-nitroanisole CTD PMID:21218109 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation
increases metabolic processing		 ISO CYP2B6 protein results in increased oxidation of 2-nitroanisole
CYP2B6 protein results in increased metabolism of 2-nitroanisole		 CTD PMID:15144223 PMID:17159769 PMID:21218109 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases oxidation EXP
ISO		 CYP2C6 protein results in increased oxidation of 2-nitroanisole
CYP2C19 protein results in increased oxidation of 2-nitroanisole		 CTD PMID:21218109 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases oxidation EXP CYP2D2 protein results in increased oxidation of 2-nitroanisole CTD PMID:21218109 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases oxidation		 ISO
EXP		 CYP2E1 protein results in increased metabolism of 2-nitroanisole
CYP2E1 protein results in increased oxidation of 2-nitroanisole		 CTD PMID:15144223 PMID:17159769 PMID:21218109 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G H2ax H2A.X variant histone increases expression EXP 2-nitroanisole results in increased expression of H2AX protein CTD PMID:26338220 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Krt14 keratin 14 increases expression EXP 2-nitroanisole results in increased expression of KRT14 protein CTD PMID:33211169 NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP 2-nitroanisole results in increased expression of NQO1 CTD PMID:11409192 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Xdh xanthine dehydrogenase increases reduction ISO XDH protein results in increased reduction of 2-nitroanisole CTD PMID:14729594 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
3-methoxytyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO 3-methoxytyramine results in increased activity of TAAR1 protein
[3-methoxytyramine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
G Vdr vitamin D receptor multiple interactions
increases abundance		 ISO Calcitriol promotes the reaction [VDR protein results in increased abundance of 3-methoxytyramine] CTD PMID:27450565 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
4-methoxyacetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO 4-acetylanisole results in increased expression of HMOX1 mRNA CTD PMID:26244607 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
4-methoxytyramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO 3-hydroxy-4-methoxyphenethylamine results in increased activity of TAAR1 protein
[3-hydroxy-4-methoxyphenethylamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
[6]-Shogaol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [shogaol results in increased expression of ADIPOQ mRNA]; shogaol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO shogaol metabolite results in increased expression of AKR1B10 protein; shogaol results in increased expression of AKR1B10 mRNA; shogaol results in increased expression of AKR1B10 protein CTD PMID:25148906 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects phosphorylation		 ISO shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
shogaol affects the phosphorylation of AKT1 protein
AKT activator SC79 affects the reaction [shogaol affects the phosphorylation of AKT1 protein]		 CTD PMID:18683823 PMID:36341865 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
affects folding		 ISO shogaol results in increased expression of BAX protein
shogaol promotes the reaction [BAX protein binds to BAX protein binds to BAX protein]; shogaol promotes the reaction [BAX protein binds to BAX protein]
shogaol affects the folding of BAX protein		 CTD PMID:18384088 PMID:25619640 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO shogaol results in decreased expression of BCL2 protein CTD PMID:18384088 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO shogaol results in decreased expression of BCL2L1 protein CTD PMID:18384088 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression		 ISO [shogaol co-treated with Hydrogen Peroxide] results in increased expression of BDNF mRNA; [shogaol co-treated with Hydrogen Peroxide] results in increased expression of BDNF protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF mRNA]
[shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein; [shogaol results in increased expression of BDNF protein] which results in increased expression of SLC5A7 protein		 CTD PMID:22381256 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; shogaol results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18384088 PMID:25619640 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO shogaol results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18384088 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression ISO shogaol results in decreased expression of CAT mRNA; shogaol results in decreased expression of CAT protein CTD PMID:36341865 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions		 ISO shogaol results in increased expression of CDH1 mRNA; shogaol results in increased expression of CDH1 protein
ferrostatin-1 inhibits the reaction [shogaol results in increased expression of CDH1 protein]		 CTD PMID:36341865 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression
affects expression		 ISO shogaol results in decreased expression of CDH2 protein
shogaol affects the expression of CDH2 mRNA		 CTD PMID:36341865 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [shogaol results in decreased expression of CFLAR protein modified form]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; shogaol promotes the reaction [Cycloheximide results in decreased expression of CFLAR protein modified form]; shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form] CTD PMID:25619640 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chat choline O-acetyltransferase multiple interactions
increases expression		 ISO [shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CHAT protein]; staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein]
[shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein; shogaol results in increased expression of CHAT protein		 CTD PMID:22381256 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of CHUK protein] CTD PMID:23899529 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO shogaol results in decreased expression of CTNNB1 mRNA; shogaol results in decreased expression of CTNNB1 protein CTD PMID:27645308 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 protein]
shogaol results in increased expression of DDIT3 mRNA; shogaol results in increased expression of DDIT3 protein		 CTD PMID:18384088 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases degradation ISO shogaol results in increased degradation of DFFA protein CTD PMID:18384088 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [shogaol results in increased expression of FABP4 mRNA] CTD PMID:18577375 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO shogaol results in increased expression of FAS protein CTD PMID:18384088 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO shogaol results in increased expression of FASLG protein CTD PMID:18384088 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression ISO shogaol results in decreased expression of FLT1 protein CTD PMID:36341865 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO shogaol metabolite results in increased expression of FTL protein; shogaol results in increased expression of FTL mRNA; shogaol results in increased expression of FTL protein CTD PMID:25148906 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO shogaol metabolite results in increased expression of GCLC protein; shogaol results in increased expression of GCLC protein
shogaol results in increased expression of GCLC mRNA
NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA]		 CTD PMID:25148906 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO shogaol metabolite results in increased expression of GCLM protein; shogaol results in increased expression of GCLM protein CTD PMID:25148906 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO shogaol results in increased expression of GDF15 mRNA CTD PMID:25148906 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions		 ISO shogaol results in decreased expression of GPX4 mRNA; shogaol results in decreased expression of GPX4 protein
ferrostatin-1 inhibits the reaction [shogaol results in decreased expression of GPX4 protein]		 CTD PMID:36341865 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO shogaol results in increased expression of and results in increased phosphorylation of GSK3B protein CTD PMID:27645308 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO shogaol analog inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein] CTD PMID:23899529 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol results in increased expression of HMOX1 protein]
shogaol analog results in increased expression of HMOX1 protein; shogaol results in increased expression of HMOX1 protein
KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of HMOX1 protein]
shogaol analog results in increased expression of HMOX1 protein; shogaol metabolite results in increased expression of HMOX1 protein; shogaol results in increased expression of HMOX1 mRNA; shogaol results in increased expression of HMOX1 protein		 CTD PMID:23899529 PMID:25148906 PMID:36341865 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of IKBKB protein] CTD PMID:23899529 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO shogaol inhibits the reaction [IL1B protein results in increased expression of PTGES protein] CTD PMID:27645308 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
increases alkylation
decreases expression		 ISO KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein]; KEAP1 protein affects the reaction [shogaol analog results in increased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [shogaol analog results in increased expression of NQO1 protein]
shogaol results in increased alkylation of KEAP1 protein
shogaol metabolite results in decreased expression of KEAP1 protein; shogaol results in decreased expression of KEAP1 protein		 CTD PMID:23899529 PMID:25148906 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
shogaol results in decreased phosphorylation of MAPK1 protein		 CTD PMID:18683823 PMID:36341865 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
shogaol results in decreased phosphorylation of MAPK3 protein		 CTD PMID:18683823 PMID:36341865 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 affects expression
multiple interactions
decreases expression		 ISO shogaol affects the expression of MMP2 mRNA
AKT activator SC79 inhibits the reaction [shogaol results in decreased expression of MMP2 protein]		 CTD PMID:36341865 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
shogaol results in decreased expression of MMP9 mRNA; shogaol results in decreased expression of MMP9 protein		 CTD PMID:23899529 PMID:36341865 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression		 ISO NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 protein]
shogaol results in increased expression of MT1 mRNA; shogaol results in increased expression of MT1 protein		 CTD PMID:25148906 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
affects localization
multiple interactions		 ISO shogaol analog results in increased expression of NFE2L2 protein
shogaol affects the localization of NFE2L2 protein
KEAP1 protein affects the reaction [shogaol analog results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [shogaol results in increased expression of MT1 protein]
shogaol affects the localization of NFE2L2 protein; shogaol metabolite affects the localization of NFE2L2 protein; shogaol metabolite affects the localization of NFE2L2 protein modified form
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; shogaol metabolite results in increased expression of and results in increased phosphorylation of NFE2L2 protein; shogaol results in increased expression of and results in increased phosphorylation of NFE2L2 protein		 CTD PMID:23899529 PMID:25148906 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; shogaol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:18683823 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of NFKBIA protein]
shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]		 CTD PMID:18683823 PMID:23899529 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]
shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; shogaol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein]		 CTD PMID:18683823 PMID:23899529 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO KEAP1 protein affects the reaction [shogaol analog results in increased expression of NQO1 protein] CTD PMID:23899529 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [shogaol results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] CTD PMID:18384088 PMID:25619640 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO shogaol results in increased activity of PPARG protein CTD PMID:18577375 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions
decreases expression		 ISO shogaol inhibits the reaction [IL1B protein results in increased expression of PTGES protein]
shogaol results in decreased expression of PTGES mRNA		 CTD PMID:27645308 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; shogaol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; shogaol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]		 CTD PMID:18683823 PMID:23899529 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO shogaol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; shogaol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; shogaol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
shogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]		 CTD PMID:18683823 PMID:23899529 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc5a7 solute carrier family 5 member 7 multiple interactions
increases expression		 ISO [shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC5A7 protein]; staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of SLC5A7 protein]
[shogaol results in increased expression of BDNF protein] which results in increased expression of SLC5A7 protein; shogaol results in increased expression of SLC5A7 protein		 CTD PMID:22381256 NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO shogaol results in decreased expression of SLC7A11 mRNA; shogaol results in decreased expression of SLC7A11 protein CTD PMID:36341865 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO shogaol results in decreased expression of SOD2 mRNA; shogaol results in decreased expression of SOD2 protein CTD PMID:36341865 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO shogaol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance		 ISO [shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[shogaol co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; CFLAR protein modified form inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; S-ethyl glutathione inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]; shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]
shogaol results in increased susceptibility to TNFSF10 protein		 CTD PMID:25619640 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 ISO shogaol results in decreased expression of VIM mRNA; shogaol results in decreased expression of VIM protein
ferrostatin-1 inhibits the reaction [shogaol results in decreased expression of VIM protein]		 CTD PMID:36341865 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
aliskiren term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance EXP ABCB1 protein affects the susceptibility to aliskiren CTD PMID:24388840 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Agt angiotensinogen multiple interactions
decreases expression		 EXP
ISO		 aliskiren inhibits the reaction [Indomethacin results in increased expression of AGT protein]
aliskiren inhibits the reaction [microcystin RR results in increased expression of AGT protein]
aliskiren results in decreased expression of AGT protein modified form		 CTD PMID:18829990 PMID:27645307 PMID:28330766 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta multiple interactions EXP [Carvedilol co-treated with aliskiren] inhibits the reaction [Isoproterenol results in increased expression of CAMK2D protein]; aliskiren inhibits the reaction [Isoproterenol results in increased expression of CAMK2D protein] CTD PMID:26982530 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Carvedilol co-treated with aliskiren] inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; aliskiren inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein] CTD PMID:26982530 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP [Carvedilol co-treated with aliskiren] inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of CKM protein]; aliskiren inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of CKM protein] CTD PMID:26982530 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO aliskiren results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP aliskiren inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA] CTD PMID:27645307 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP aliskiren inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA] CTD PMID:27645307 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP aliskiren inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA] CTD PMID:27645307 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ren renin multiple interactions
decreases activity		 ISO
EXP		 [aliskiren co-treated with Atenolol] results in decreased activity of REN protein
[aliskiren co-treated with Carvedilol] inhibits the reaction [Isoproterenol results in increased activity of REN protein]; aliskiren inhibits the reaction [Indomethacin results in increased expression of REN protein]; aliskiren inhibits the reaction [Isoproterenol results in increased activity of REN protein]
aliskiren results in decreased activity of REN protein		 CTD PMID:18957387 PMID:26982530 PMID:27645307 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP aliskiren inhibits the reaction [Indomethacin results in increased expression of TNF mRNA] CTD PMID:27645307 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
anethole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO anethole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO anethole results in decreased phosphorylation of AKT1 protein CTD PMID:21212515 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; anethole inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA] CTD PMID:35430261 PMID:39029857 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; anethole inhibits the reaction [Isoproterenol results in increased expression of BCL2 mRNA] CTD PMID:35430261 PMID:39029857 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; anethole inhibits the reaction [Isoproterenol results in increased cleavage of CASP3 protein] CTD PMID:35430261 PMID:39029857 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; anethole inhibits the reaction [Isoproterenol results in increased cleavage of CASP9 protein] CTD PMID:35430261 PMID:39029857 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; anethole inhibits the reaction [Isoproterenol results in decreased activity of CAT protein] CTD PMID:35430261 PMID:39029857 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cst3 cystatin C multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in increased expression of CST3 protein] CTD PMID:39029857 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO anethole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions		 ISO
EXP		 anethole metabolite binds to ESR1 protein
anethole analog binds to ESR1 protein
anethole metabolite inhibits the reaction [Estradiol binds to ESR1 protein]		 CTD PMID:12818366 PMID:27420082 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 decreases activity EXP anethole analog results in decreased activity of GGT1 protein CTD PMID:20171274 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP anethole results in increased expression of GSTA2 protein CTD PMID:8406240 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein] CTD PMID:39029857 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP anethole promotes the reaction [Isoproterenol results in increased expression of HMOX1 mRNA]; anethole promotes the reaction [Isoproterenol results in increased expression of HMOX1 protein] CTD PMID:35430261 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases activity ISO anethole results in decreased activity of IKBKB protein CTD PMID:10871845 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]; anethole inhibits the reaction [Isoproterenol results in increased expression of IL1B protein] CTD PMID:35430261 PMID:39029857 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO anethole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; anethole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein] CTD PMID:16531003 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in increased expression of IL6 protein]; anethole inhibits the reaction [Isoproterenol results in increased expression of IL6 protein] CTD PMID:35430261 PMID:39029857 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 mRNA]; anethole inhibits the reaction [Isoproterenol results in increased expression of KEAP1 protein] CTD PMID:35430261 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in increased expression of LCN2 protein] CTD PMID:39029857 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:10871845 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO anethole results in decreased phosphorylation of MAPK1 protein CTD PMID:21212515 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO anethole results in decreased phosphorylation of MAPK3 protein CTD PMID:21212515 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO anethole inhibits the reaction [TNF protein results in increased activity of MAPK8 protein] CTD PMID:10871845 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
decreases activity		 ISO anethole results in decreased expression of MMP2 mRNA
anethole results in decreased activity of MMP2 protein		 CTD PMID:21212515 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression		 ISO anethole results in decreased activity of MMP9 protein
anethole results in decreased expression of MMP9 mRNA		 CTD PMID:21212515 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in increased expression of MYD88 mRNA]; anethole inhibits the reaction [Isoproterenol results in increased expression of MYD88 mRNA]; anethole inhibits the reaction [Isoproterenol results in increased expression of MYD88 protein] CTD PMID:35430261 PMID:39029857 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP anethole promotes the reaction [Isoproterenol results in increased expression of NFE2L2 mRNA]; anethole promotes the reaction [Isoproterenol results in increased expression of NFE2L2 protein] CTD PMID:35430261 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP		 anethole inhibits the reaction [Ceramides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
anethole inhibits the reaction [Doxorubicin results in increased expression of NFKB1 mRNA]		 CTD PMID:10871845 PMID:39029857 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases degradation		 ISO anethole inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anethole inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
anethole results in decreased degradation of NFKBIA protein		 CTD PMID:10871845 PMID:21212515 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:10871845 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO anethole results in decreased expression of PLAU mRNA CTD PMID:21212515 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 anethole inhibits the reaction [Ceramides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
anethole inhibits the reaction [Isoproterenol results in increased expression of RELA protein]		 CTD PMID:10871845 PMID:35430261 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO anethole results in increased expression of TIMP1 mRNA CTD PMID:21212515 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP anethole inhibits the reaction [Doxorubicin results in increased expression of TLR4 mRNA]; anethole inhibits the reaction [Isoproterenol results in increased expression of TLR4 mRNA]; anethole inhibits the reaction [Isoproterenol results in increased expression of TLR4 protein] CTD PMID:35430261 PMID:39029857 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein]; anethole inhibits the reaction [TNF protein results in increased activity of MAPK8 protein]; anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]; anethole inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anethole inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
anethole inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; anethole inhibits the reaction [Isoproterenol results in increased expression of TNF protein]		 CTD PMID:10871845 PMID:35430261 PMID:39029857 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP anethole inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:35430261 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
BI-2536 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp8 caspase 8 increases activity ISO BI 2536 results in increased activity of CASP8 protein CTD PMID:24403256 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO BI 2536 inhibits the reaction [Arsenic Trioxide results in decreased expression of NOTCH1 protein]; BI 2536 inhibits the reaction [Nocodazole results in decreased expression of NOTCH1 protein] CTD PMID:31597699 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Plk1 polo-like kinase 1 decreases activity
multiple interactions		 ISO BI 2536 results in decreased activity of PLK1 protein
BI 2536 inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of PLK1 protein]		 CTD PMID:24748653 PMID:31597699 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
capsiate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 Cd69 molecule decreases localization ISO capsiate analog results in decreased localization of CD69 protein CTD PMID:12115659 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases localization ISO capsiate analog results in decreased localization of ICAM1 protein CTD PMID:12115659 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO capsiate results in increased expression of IGF1 protein CTD PMID:17307377 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions ISO capsiate analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased activity of IKBKG protein] CTD PMID:12115659 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases localization ISO capsiate analog results in decreased localization of IL2RA protein CTD PMID:12115659 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO capsiate analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased degradation of NFKBIA protein] CTD PMID:12115659 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ucp3 uncoupling protein 3 decreases expression EXP capsiate results in decreased expression of UCP3 mRNA CTD PMID:17264228 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
coniferyl aldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO coniferaldehyde results in increased expression of ABCC2 mRNA CTD PMID:26275128 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO coniferaldehyde results in increased expression of ABCC3 mRNA CTD PMID:26275128 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions
increases expression		 ISO NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]
coniferaldehyde results in increased expression of AKR1C1 mRNA; coniferaldehyde results in increased expression of AKR1C1 protein		 CTD PMID:26275128 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO coniferaldehyde results in increased expression of AKR1C2 mRNA; coniferaldehyde results in increased expression of AKR1C2 protein CTD PMID:26275128 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO coniferaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:26275128 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO coniferaldehyde results in increased expression of GCLC mRNA CTD PMID:26275128 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO coniferaldehyde results in increased expression of GCLM mRNA CTD PMID:26275128 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO coniferaldehyde results in increased expression of GSR mRNA
coniferaldehyde results in increased expression of GSR protein		 CTD PMID:26275128 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]
coniferaldehyde results in increased expression of HMOX1 mRNA; coniferaldehyde results in increased expression of HMOX1 protein		 CTD PMID:26275128 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ifng interferon gamma multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]		 CTD PMID:27378624 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression
multiple interactions		 ISO coniferaldehyde results in increased expression of MUC5AC mRNA
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; A 967079 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; coniferaldehyde results in increased expression of and results in increased secretion of MUC5AC protein; TWS 119 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]		 CTD PMID:31944254 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein; MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]
coniferaldehyde results in increased expression of NFE2L2 protein		 CTD PMID:26275128 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]		 CTD PMID:27378624 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO coniferaldehyde results in increased expression of NQO1 protein CTD PMID:26275128 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pkn3 protein kinase N3 multiple interactions ISO PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr 3:13,350,082...13,363,572
Ensembl chr 3:13,335,041...13,363,567 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]		 CTD PMID:27378624 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO coniferaldehyde results in increased activity of TRPA1 protein CTD PMID:23541125 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO coniferaldehyde results in increased expression of TXNRD1 mRNA CTD PMID:26275128 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
enrasentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ednra endothelin receptor type A multiple interactions ISO enrasentan binds to and results in decreased activity of EDNRA protein CTD PMID:16219361 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO enrasentan binds to and results in decreased activity of EDNRB protein CTD PMID:16219361 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
estragole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO estragole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Casp3 caspase 3 increases expression EXP estragole results in increased expression of CASP3 protein modified form CTD PMID:29054680 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccna2 cyclin A2 increases expression EXP estragole results in increased expression of CCNA2 mRNA CTD PMID:29054680 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions		 EXP
ISO		 estragole results in increased expression of CCNB1 mRNA
flumequine promotes the reaction [estragole results in increased expression of CCNB1 mRNA]		 CTD PMID:29054680 PMID:31029721 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP estragole results in increased expression of CCND1 protein CTD PMID:29054680 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions		 EXP
ISO		 estragole results in increased expression of CCNE1 mRNA
[flumequine co-treated with estragole] results in increased expression of CCNE1 mRNA		 CTD PMID:29054680 PMID:31029721 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression EXP estragole results in increased expression of CHEK1 protein CTD PMID:29054680 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO estragole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation
increases response to substance
multiple interactions
increases expression		 ISO CYP1A2 protein results in increased hydroxylation of estragole
CYP1A2 protein results in increased susceptibility to estragole
[flumequine co-treated with estragole] results in increased expression of CYP1A2 mRNA
estragole results in increased expression of CYP1A2 mRNA		 CTD PMID:19920071 PMID:31029721 PMID:32853702 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases hydroxylation ISO CYP2E1 protein results in increased hydroxylation of estragole CTD PMID:19920071 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP estragole results in increased phosphorylation of GSK3B protein CTD PMID:29054680 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone increases expression EXP estragole results in increased expression of H2AX protein modified form CTD PMID:29054680 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK1 protein CTD PMID:29054680 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK3 protein CTD PMID:29054680 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK8 protein CTD PMID:29054680 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK9 protein CTD PMID:29054680 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP estragole results in increased expression of PCNA protein CTD PMID:22576464 PMID:29054680 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha increases phosphorylation EXP estragole results in increased phosphorylation of PPP2CA protein CTD PMID:29054680 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Rad51 RAD51 recombinase increases expression EXP estragole results in increased expression of RAD51 protein CTD PMID:29054680 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation EXP estragole results in increased phosphorylation of SRC protein CTD PMID:29054680 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [flumequine co-treated with estragole] results in increased expression of TNF mRNA CTD PMID:31029721 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases phosphorylation EXP estragole results in increased phosphorylation of TP53 protein CTD PMID:29054680 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [flumequine co-treated with estragole] results in decreased expression of UGT1A1 mRNA CTD PMID:31029721 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
ethyl vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Or5d18 olfactory receptor family 5 subfamily D member 18 multiple interactions ISO [ethyl vanillin binds to and results in increased activity of OR5D18 protein] which results in increased transport of Calcium; ethyl vanillin binds to and results in increased activity of OR5D18 protein CTD PMID:15716417 NCBI chr 3:73,516,522...73,517,463
Ensembl chr 3:73,516,364...73,519,858
Ensembl chr 3:73,516,364...73,519,858 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO ethyl vanillin results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
eugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca6 ATP binding cassette subfamily A member 6 decreases expression ISO Eugenol results in decreased expression of ABCA6 mRNA CTD PMID:17374397 NCBI chr10:95,142,805...95,212,087
Ensembl chr10:95,142,966...95,211,530 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Eugenol inhibits the reaction [Chlorpyrifos results in decreased expression of ACHE protein] CTD PMID:32096903 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
affects localization		 ISO [Eugenol co-treated with acetyleugenol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [Eugenol co-treated with acetyleugenol] results in increased activity of AHR protein; Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of AHR protein]; Eugenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
Eugenol results in increased activity of AHR protein
Eugenol affects the localization of AHR protein		 CTD PMID:17275817 PMID:22686307 PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO Eugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases expression ISO Eugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Eugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472 PMID:26198647 PMID:30806763 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO Eugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Eugenol results in increased expression of AKR1C2 mRNA CTD PMID:26198647 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO Eugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alb albumin multiple interactions EXP Eugenol inhibits the reaction [Streptozocin results in decreased expression of ALB protein] CTD PMID:38047382 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Eugenol results in increased expression of ALPL mRNA CTD PMID:22083529 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein] CTD PMID:20434464 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Ar androgen receptor multiple interactions ISO Eugenol binds to and results in decreased activity of AR protein CTD PMID:20226658 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arhgap17 Rho GTPase activating protein 17 decreases expression ISO Eugenol results in decreased expression of ARHGAP17 mRNA CTD PMID:17374397 NCBI chr 1:177,807,579...177,897,027
Ensembl chr 1:177,807,583...177,896,854 		JBrowse link
G Arl4c ARF like GTPase 4C increases expression ISO Eugenol results in increased expression of ARL4C mRNA CTD PMID:17374397 NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Eugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G B2m beta-2 microglobulin increases expression ISO Eugenol results in increased expression of B2M mRNA CTD PMID:17936526 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAD mRNA] CTD PMID:20434464 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
Eugenol results in increased expression of BAX mRNA		 CTD PMID:20434464 PMID:20537511 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [Eugenol results in increased activity of sulforaphane] which results in decreased expression of BCL2; [sulforaphane results in increased activity of Eugenol] which results in decreased expression of BCL2
Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of BCL2 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]
Eugenol results in decreased expression of BCL2 mRNA		 CTD PMID:20434464 PMID:20537511 PMID:21382956 PMID:21939359 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2L1 mRNA] CTD PMID:20434464 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bclaf1 BCL2-associated transcription factor 1 decreases expression ISO Eugenol results in decreased expression of BCLAF1 mRNA CTD PMID:17374397 NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Eugenol results in increased expression of BDNF mRNA CTD PMID:15157811 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BID mRNA] CTD PMID:20434464 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Eugenol results in increased expression of BMP6 mRNA CTD PMID:17374397 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO Eugenol results in decreased expression of BUB1 mRNA CTD PMID:17374397 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650 		JBrowse link
G Calcrl calcitonin receptor like receptor increases expression ISO Eugenol results in increased expression of CALCRL mRNA CTD PMID:17374397 NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
increases cleavage		 ISO
EXP		 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]
Eugenol results in increased expression of CASP3 mRNA
Eugenol results in increased activity of CASP3 protein
Eugenol inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 protein]; Eugenol inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
Eugenol results in increased expression of CASP3 protein modified form
Eugenol results in increased cleavage of CASP3 protein		 CTD PMID:20434464 PMID:20537511 PMID:21656368 PMID:25455450 PMID:30518369 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases expression ISO Eugenol results in increased expression of CASP7 mRNA CTD PMID:30518369 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity		 ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]
Eugenol results in increased expression of CASP9 mRNA
Eugenol results in increased activity of CASP9 protein		 CTD PMID:20434464 PMID:25455450 PMID:30518369 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases expression
decreases activity
multiple interactions		 ISO
EXP		 Eugenol results in increased expression of CAT mRNA
Eugenol results in decreased activity of CAT protein
Eugenol inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Eugenol inhibits the reaction [Chlorpyrifos results in decreased expression of CAT protein]
CAT protein inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]		 CTD PMID:15576237 PMID:20566472 PMID:32096903 PMID:33245926 PMID:36007673 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 increases expression ISO Eugenol results in increased expression of CCL13 mRNA CTD PMID:17936526 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression ISO Eugenol results in increased expression of CCL19 mRNA CTD PMID:17936526 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
increases secretion
decreases expression		 ISO Eugenol results in increased expression of CCL2 mRNA
Eugenol results in increased secretion of CCL2 protein
Eugenol results in decreased expression of CCL2 mRNA		 CTD PMID:15585374 PMID:17374397 PMID:17936526 PMID:22245253 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Eugenol results in increased expression of CCL20 mRNA CTD PMID:30806763 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
increases secretion		 ISO Eugenol results in increased expression of CCL3 mRNA
Eugenol results in increased secretion of CCL3 protein		 CTD PMID:15585374 PMID:23624239 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression
increases secretion		 ISO Eugenol results in increased expression of CCL4 mRNA; Eugenol results in increased expression of CCL4 protein
Eugenol results in increased secretion of CCL4 protein		 CTD PMID:15585374 PMID:18353026 PMID:30806763 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCNB1 mRNA] CTD PMID:19851710 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA] CTD PMID:19851710 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO Eugenol results in decreased expression of CCR2 mRNA CTD PMID:17374397 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Eugenol results in increased expression of CCR5 mRNA CTD PMID:17936526 PMID:20713136 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 increases expression ISO Eugenol results in increased expression of CCR7 mRNA CTD PMID:17374397 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Cd24 CD24 molecule decreases expression ISO Eugenol results in decreased expression of CD24 protein CTD PMID:31926151 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cd274 CD274 molecule increases expression ISO Eugenol results in increased expression of CD274 protein CTD PMID:23624239 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd36 CD36 molecule decreases expression ISO Eugenol results in decreased expression of CD36 mRNA CTD PMID:17374397 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd44 CD44 molecule decreases expression ISO Eugenol results in decreased expression of CD44 protein CTD PMID:31926151 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression		 ISO [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein] CTD PMID:12423654 PMID:20488241 PMID:21742781 PMID:23624239 PMID:30806763 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Eugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO
EXP		 Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN1A protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1A protein]		 CTD PMID:19851710 PMID:20043298 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Eugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression ISO Eugenol results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250 		JBrowse link
G Clec4a3 C-type lectin domain family 4, member A3 decreases expression ISO Eugenol results in decreased expression of CLEC4A protein CTD PMID:23624239 NCBI chr 4:156,214,030...156,224,818
Ensembl chr 4:156,214,718...156,224,817 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 affects expression ISO Eugenol affects the expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Eugenol results in increased expression of CREM mRNA CTD PMID:17374397 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO Eugenol results in decreased expression of and affects the phosphorylation of and affects the localization of CTNNB1 protein
Eugenol results in decreased expression of CTNNB1 mRNA		 CTD PMID:31926151 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsl cathepsin L increases expression ISO Eugenol results in increased expression of CTSL mRNA CTD PMID:17374397 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO Eugenol results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions		 ISO Eugenol results in increased expression of CXCL1 mRNA
Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]		 CTD PMID:12963494 PMID:20713136 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Eugenol results in increased expression of CXCR4 mRNA CTD PMID:20713136 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS protein] CTD PMID:20434464 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases expression
decreases activity		 ISO [CYP1A1 protein co-treated with Copper] results in increased activity of Eugenol; Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Eugenol inhibits the reaction [CYP1A1 protein results in increased metabolism of and results in increased activity of 9,10-Dimethyl-1,2-benzanthracene]; Eugenol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Eugenol results in increased expression of CYP1A1 mRNA
Eugenol results in decreased expression of CYP1A1 mRNA
Eugenol results in decreased activity of CYP1A1 protein		 CTD PMID:15576237 PMID:17275817 PMID:20713136 PMID:22686307 PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with Copper] results in increased activity of Eugenol CTD PMID:15576237 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity		 ISO Eugenol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; Eugenol inhibits the reaction [CYP1B1 protein results in increased metabolism of and results in increased activity of 9,10-Dimethyl-1,2-benzanthracene]
Eugenol results in decreased activity of CYP1B1 protein		 CTD PMID:17275817 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Eugenol results in decreased expression of CYP27A1 mRNA CTD PMID:20713136 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases metabolic processing		 ISO [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol; [CYP2D6 protein results in increased metabolism of Eugenol] which results in increased abundance of 2-hydroxychavicol; [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; bathocuproine inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]; CAT protein inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol]; methional inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] CTD PMID:15576237 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO		 Eugenol inhibits the reaction [Thioacetamide results in increased expression of CYP2E1 protein]
[CYP2E1 protein co-treated with Copper] results in increased activity of Eugenol		 CTD PMID:15576237 PMID:20036707 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dkc1 dyskerin pseudouridine synthase 1 decreases expression ISO Eugenol results in decreased expression of DKC1 mRNA CTD PMID:17374397
G Dlgap5 DLG associated protein 5 decreases expression ISO Eugenol results in decreased expression of DLGAP5 mRNA CTD PMID:17374397 NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Eugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411 PMID:27965148 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal increases expression ISO Eugenol results in increased expression of DNASE2A mRNA CTD PMID:15618236 NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Eugenol CTD PMID:9537685 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Eugenol results in increased expression of DUSP1 mRNA CTD PMID:30806763 NCBI chr10:16,680,478...16,683,275 JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Eugenol results in decreased expression of E2F1 mRNA; Eugenol results in decreased expression of E2F1 protein CTD PMID:15574415 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO Eugenol results in decreased expression of E2F2 mRNA; Eugenol results in decreased expression of E2F2 protein CTD PMID:15574415 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G E2f3 E2F transcription factor 3 decreases expression ISO Eugenol results in decreased expression of E2F3 mRNA; Eugenol results in decreased expression of E2F3 protein CTD PMID:15574415 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253 		JBrowse link
G E2f4 E2F transcription factor 4 decreases expression ISO Eugenol results in decreased expression of E2F4 mRNA CTD PMID:15574415 NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806 		JBrowse link
G E2f5 E2F transcription factor 5 decreases expression ISO Eugenol results in decreased expression of E2F5 mRNA CTD PMID:15574415 NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990 		JBrowse link
G E2f6 E2F transcription factor 6 increases expression ISO Eugenol results in increased expression of E2F6 mRNA CTD PMID:15574415 NCBI chr 6:39,592,224...39,608,685
Ensembl chr 6:39,592,228...39,608,683 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression
increases expression		 ISO Eugenol results in decreased expression of EGFR protein
Eugenol results in increased expression of EGFR mRNA		 CTD PMID:15618236 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [[Eugenol results in increased activity of OR5D18 protein] which results in increased abundance of Cyclic AMP] which results in increased expression of EGR1 mRNA CTD PMID:12767924 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr2 early growth response 2 decreases expression ISO Eugenol results in decreased expression of EGR2 mRNA CTD PMID:17374397 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Emb embigin decreases expression ISO Eugenol results in decreased expression of EMB mRNA CTD PMID:17374397 NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050 		JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression ISO Eugenol results in decreased expression of EPCAM protein
Eugenol results in decreased expression of EPCAM mRNA; Eugenol results in decreased expression of EPCAM protein		 CTD PMID:31926151 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions		 ISO Eugenol binds to ESR1 protein
Eugenol inhibits the reaction [Estradiol binds to ESR1 protein]		 CTD PMID:12495555 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions		 ISO Eugenol binds to ESR2 protein
Eugenol inhibits the reaction [Estradiol binds to ESR2 protein]		 CTD PMID:12495555 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F13a1 coagulation factor XIII A1 chain decreases expression ISO Eugenol results in decreased expression of F13A1 mRNA CTD PMID:17374397 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO Eugenol results in decreased expression of FASN mRNA CTD PMID:21870829 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbxo9 f-box protein 9 decreases expression ISO Eugenol results in decreased expression of FBXO9 mRNA CTD PMID:17374397 NCBI chr 8:78,958,482...78,984,015
Ensembl chr 8:78,958,483...78,983,949 		JBrowse link
G Fcgr2b Fc gamma receptor 2B increases expression ISO Eugenol results in increased expression of FCGR2B mRNA CTD PMID:17374397 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fech ferrochelatase increases expression ISO Eugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Ferry3 FERRY endosomal RAB5 effector complex subunit 3 decreases expression ISO Eugenol results in decreased expression of FERRY3 mRNA CTD PMID:17374397 NCBI chr 4:159,772,693...159,809,322
Ensembl chr 4:159,772,786...159,806,382 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA] CTD PMID:20434464 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression ISO Eugenol results in increased expression of FOSL2 mRNA CTD PMID:17374397 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Eugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO Eugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of GADD45A mRNA] CTD PMID:19851710 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Eugenol results in increased expression of GADD45B mRNA CTD PMID:15618236 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Eugenol results in increased expression of GCLC mRNA CTD PMID:20566472 PMID:26198647 PMID:30806763 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Eugenol results in increased expression of GCLM mRNA CTD PMID:20566472 PMID:26198647 PMID:27965148 PMID:30806763 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Eugenol results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Eugenol inhibits the reaction [Streptozocin results in increased expression of GPT protein] CTD PMID:38047382 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Eugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression ISO Eugenol results in increased expression of GSK3B mRNA CTD PMID:17374397 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Eugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Eugenol analog results in decreased activity of GSTA1 protein CTD PMID:8620581 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression
decreases activity		 EXP Eugenol results in increased expression of GSTA2 protein
Eugenol analog results in decreased activity of GSTA2 protein		 CTD PMID:8406240 PMID:8620581 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases activity EXP Eugenol analog results in decreased activity of GSTA3 protein CTD PMID:8620581 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO
EXP		 Eugenol analog results in decreased activity of GSTM1 protein CTD PMID:8620581 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity EXP Eugenol analog results in decreased activity of GSTM2 protein CTD PMID:8620581 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO
EXP		 Eugenol analog results in decreased activity of GSTP1 protein CTD PMID:8620581 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Heatr5b HEAT repeat containing 5B decreases expression ISO Eugenol results in decreased expression of HEATR5B mRNA CTD PMID:17374397 NCBI chr 6:16,243,424...16,323,444
Ensembl chr 6:16,243,461...16,323,435 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Eugenol results in increased expression of HIF1A mRNA CTD PMID:20713136 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO Eugenol results in decreased expression of HMGCR mRNA CTD PMID:21870829 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Eugenol results in increased expression of HMOX1 mRNA CTD PMID:20566472 PMID:20713136 PMID:23445166 PMID:26244607 PMID:30806763 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 decreases expression ISO Eugenol results in decreased expression of HNRNPA3 mRNA CTD PMID:17374397 NCBI chr 3:60,578,574...60,588,755
Ensembl chr 3:60,578,673...60,588,306 		JBrowse link
G Hras HRas proto-oncogene, GTPase decreases expression ISO Eugenol results in decreased expression of HRAS protein CTD PMID:20537511 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO Eugenol results in increased expression of HSPA6 mRNA CTD PMID:23999411 NCBI chr13:83,273,176...83,274,317 JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO Eugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Ibsp integrin-binding sialoprotein decreases expression ISO Eugenol results in decreased expression of IBSP mRNA; Eugenol results in decreased expression of IBSP protein CTD PMID:21706355 NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Eugenol results in increased expression of ICAM1 mRNA; Eugenol results in increased expression of ICAM1 protein CTD PMID:30806763 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Eugenol results in decreased expression of IDI1 mRNA CTD PMID:17374397 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Ifng interferon gamma increases secretion
multiple interactions		 ISO Eugenol results in increased secretion of IFNG protein
[Methoxychlor co-treated with Eugenol] results in increased expression of IFNG protein; [Parathion co-treated with Eugenol] results in increased expression of IFNG protein		 CTD PMID:20920556 PMID:22245253 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of IKBKB protein] CTD PMID:19851710 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Eugenol inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA] CTD PMID:21237301 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]] CTD PMID:21237301 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Eugenol inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]] CTD PMID:21237301 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il16 interleukin 16 multiple interactions
increases secretion		 ISO Eugenol results in increased expression of and results in increased secretion of IL16 protein
Eugenol results in increased secretion of IL16 protein		 CTD PMID:23624239 PMID:30806763 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il18 interleukin 18 increases expression ISO Eugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Eugenol results in increased expression of IL1A mRNA CTD PMID:30806763 PMID:33715048 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression		 ISO [Eugenol results in increased activity of sulforaphane] which results in decreased expression of IL1B; [sulforaphane results in increased activity of Eugenol] which results in decreased expression of IL1B; Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL1B protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Eugenol results in increased expression of IL1B mRNA
Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Eugenol results in decreased expression of IL1B mRNA		 CTD PMID:12963494 PMID:17509409 PMID:20713136 PMID:21382956 PMID:21807015 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO Eugenol results in increased expression of IL1R2 mRNA CTD PMID:20713136 PMID:30806763 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725 		JBrowse link
G Il2 interleukin 2 increases expression
increases secretion		 ISO Eugenol results in increased expression of IL2 protein
Eugenol results in increased secretion of IL2 protein		 CTD PMID:22245253 PMID:22381623 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4r interleukin 4 receptor increases expression ISO Eugenol results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
increases expression		 ISO
EXP		 Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased secretion of IL6 protein]
Eugenol results in increased secretion of IL6 protein
Eugenol inhibits the reaction [Thioacetamide results in increased activity of IL6 protein]
Eugenol results in increased expression of IL6 mRNA		 CTD PMID:20036707 PMID:20043298 PMID:21870829 PMID:22245253 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il7r interleukin 7 receptor increases expression ISO Eugenol results in increased expression of IL7R mRNA CTD PMID:20713136 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Inhba inhibin subunit beta A decreases expression ISO Eugenol results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Ipcef1 interaction protein for cytohesin exchange factors 1 decreases expression ISO Eugenol results in decreased expression of IPCEF1 mRNA CTD PMID:17374397 NCBI chr 1:43,237,903...43,451,735
Ensembl chr 1:43,269,202...43,427,969 		JBrowse link
G Itga6 integrin subunit alpha 6 increases expression ISO Eugenol results in increased expression of ITGA6 mRNA CTD PMID:17936526 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itgb1 integrin subunit beta 1 increases expression ISO Eugenol results in increased expression of ITGB1 mRNA CTD PMID:17936526 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases activity ISO Eugenol results in decreased activity of KCNA5 protein CTD PMID:17720863 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 decreases expression ISO Eugenol results in decreased expression of KCNJ2 mRNA CTD PMID:17374397 NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445 		JBrowse link
G Kif23 kinesin family member 23 decreases expression ISO Eugenol results in decreased expression of KIF23 mRNA CTD PMID:17374397 NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Eugenol results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO Eugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO Eugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048 		JBrowse link
G Mcts1 MCTS1, re-initiation and release factor decreases expression ISO Eugenol results in decreased expression of MCTS1 mRNA CTD PMID:17374397 NCBI chr  X:117,350,723...117,362,504
Ensembl chr  X:117,350,889...117,362,504 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO Eugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Eugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mir146a microRNA 146a increases expression ISO Eugenol results in increased expression of MIR146A mRNA CTD PMID:37326882 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 EXP
ISO		 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP2 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP2 mRNA]
Eugenol results in decreased expression of MMP2 mRNA		 CTD PMID:20434464 PMID:30518369 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 EXP
ISO		 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP9 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP9 mRNA]
Eugenol results in decreased expression of MMP9 mRNA		 CTD PMID:20434464 PMID:30518369 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Eugenol inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Eugenol inhibits the reaction [Thioacetamide results in increased activity of MPO protein] CTD PMID:20036707 PMID:33245926 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrpl35 mitochondrial ribosomal protein L35 decreases expression ISO Eugenol results in decreased expression of MRPL35 mRNA CTD PMID:17374397 NCBI chr 4:103,865,812...103,876,687
Ensembl chr 4:103,865,812...103,880,887 		JBrowse link
G Ms4a7 membrane spanning 4-domains A7 increases expression ISO Eugenol results in increased expression of MS4A7 mRNA CTD PMID:17374397 NCBI chr 1:207,969,117...207,984,743
Ensembl chr 1:207,968,761...207,983,260 		JBrowse link
G Mt3 metallothionein 3 increases expression ISO Eugenol results in increased expression of MT3 mRNA CTD PMID:15157811 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases activity EXP Eugenol results in increased activity of MTOR protein CTD PMID:36007673 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mxd1 max dimerization protein 1 increases expression ISO Eugenol results in increased expression of MXD1 mRNA CTD PMID:20713136 NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751 		JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO Eugenol results in decreased expression of MYB mRNA CTD PMID:17374397 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MYC protein] CTD PMID:20537511 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO Eugenol results in increased expression of NAMPT mRNA CTD PMID:17374397 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects expression
decreases expression
multiple interactions		 ISO Eugenol affects the expression of NFE2L2 protein
Eugenol results in decreased expression of NFE2L2 mRNA
Eugenol promotes the reaction [NFE2L2 protein results in increased expression of NQO1 mRNA]		 CTD PMID:17275817 PMID:31967339 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects expression		 ISO
EXP		 Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol affects the expression of NFKB1 mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]		 CTD PMID:10871845 PMID:19851710 PMID:20385217 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO		 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKBIA protein modified form]
Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKBIA protein modified form]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]		 CTD PMID:12963494 PMID:19851710 PMID:20043298 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NOS2 protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Eugenol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] CTD PMID:20043298 PMID:21237301 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Notch1 notch receptor 1 decreases expression ISO Eugenol results in decreased expression of NOTCH1 protein
Eugenol results in decreased expression of NOTCH1 mRNA; Eugenol results in decreased expression of NOTCH1 protein		 CTD PMID:31926151 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
increases activity
multiple interactions		 ISO Eugenol results in increased expression of NQO1 mRNA; Eugenol results in increased expression of NQO1 protein
Eugenol results in increased activity of NQO1 protein
[Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]; Eugenol promotes the reaction [NFE2L2 protein results in increased expression of NQO1 mRNA]		 CTD PMID:17275817 PMID:20566472 PMID:21742781 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO Eugenol results in increased expression of NR1I2 mRNA CTD PMID:29933105 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nup88 nucleoporin 88 increases expression ISO Eugenol results in increased expression of NUP88 mRNA CTD PMID:17374397 NCBI chr10:55,667,903...55,692,249
Ensembl chr10:55,667,906...55,692,257 		JBrowse link
G Or5d18 olfactory receptor family 5 subfamily D member 18 multiple interactions
increases activity
affects binding		 ISO [[Eugenol results in increased activity of OR5D18 protein] which results in increased abundance of Cyclic AMP] which results in increased expression of EGR1 mRNA; [Eugenol binds to and results in increased activity of OR5D18 protein] which results in increased abundance of Cyclic AMP; [Eugenol binds to and results in increased activity of OR5D18 protein] which results in increased transport of Calcium; [Eugenol binds to OR5D18 protein] which results in increased transport of Calcium; [Eugenol results in increased activity of OR5D18 protein] which results in increased abundance of Cyclic AMP; Eugenol binds to and results in increased activity of OR5D18 protein; isomethyleugenol inhibits the reaction [[Eugenol binds to OR5D18 protein] which results in increased transport of Calcium] CTD PMID:12767924 PMID:14685265 PMID:15716417 PMID:19723634 NCBI chr 3:73,516,522...73,517,463
Ensembl chr 3:73,516,364...73,519,858
Ensembl chr 3:73,516,364...73,519,858 		JBrowse link
G P2rx3 purinergic receptor P2X 3 multiple interactions EXP Eugenol inhibits the reaction [P2RX3 protein affects the activity of Adenosine Triphosphate] CTD PMID:19967073 NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178 		JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase decreases expression ISO Eugenol results in decreased expression of PAICS mRNA CTD PMID:17374397 NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Eugenol affects the reaction [Methylnitronitrosoguanidine affects the cleavage of PARP1 protein] CTD PMID:20434464 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO
EXP		 Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCNA protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA protein]		 CTD PMID:19851710 PMID:20043298 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pde4b phosphodiesterase 4B increases expression ISO Eugenol results in increased expression of PDE4B mRNA CTD PMID:17374397 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO Eugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein increases expression ISO Eugenol results in increased expression of PICALM mRNA CTD PMID:17374397 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression EXP
ISO		 Eugenol results in increased expression of PIK3R1 mRNA CTD PMID:20724125 PMID:21870829 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Eugenol results in increased expression of PLAT mRNA CTD PMID:17374397 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Eugenol results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Eugenol results in decreased expression of POU5F1 protein
Eugenol results in decreased expression of POU5F1 mRNA; Eugenol results in decreased expression of POU5F1 protein		 CTD PMID:31926151 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO Eugenol analog binds to and results in increased activity of PPARG protein
Eugenol results in increased expression of PPARG mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Eugenol analog binds to and results in increased activity of PPARG protein]; Eugenol analog binds to and results in increased activity of PPARG protein		 CTD PMID:20064974 PMID:21870829 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppbp pro-platelet basic protein multiple interactions
increases expression		 ISO Eugenol results in increased expression of and results in increased secretion of PPBP protein
Eugenol results in increased expression of PPBP mRNA		 CTD PMID:23624239 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130 		JBrowse link
G Prdx3 peroxiredoxin 3 decreases expression ISO Eugenol results in decreased expression of PRDX3 mRNA CTD PMID:17374397 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression ISO Eugenol results in decreased expression of PTGER3 mRNA CTD PMID:17374397 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO Eugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases expression		 ISO
EXP		 Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA]; Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Eugenol results in increased expression of PTGS2 mRNA
Eugenol results in decreased expression of PTGS2 mRNA
Eugenol inhibits the reaction [Thioacetamide results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Thioacetamide results in increased expression of PTGS2]
Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone]; Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased metabolism of Arachidonic Acid]; Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Eugenol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]		 CTD PMID:12757841 PMID:16101137 PMID:17509409 PMID:20036707 PMID:20043298 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Eugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK protein] CTD PMID:20434464 NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of RELA protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA protein]		 CTD PMID:10871845 PMID:19851710 PMID:20043298 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Eugenol results in increased expression of RGS1 mRNA CTD PMID:17374397 PMID:20713136 NCBI chr13:56,018,546...56,022,889
Ensembl chr13:56,018,554...56,022,984 		JBrowse link
G Rpl27a ribosomal protein L27A increases expression ISO Eugenol results in increased expression of RPL27A mRNA CTD PMID:17374397 NCBI chr 1:163,539,732...163,542,771 JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO Eugenol results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Eugenol results in increased expression of SAT1 mRNA CTD PMID:17374397 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Sdc2 syndecan 2 increases expression ISO Eugenol results in increased expression of SDC2 mRNA CTD PMID:17374397 NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081 		JBrowse link
G Septin11 septin 11 decreases expression ISO Eugenol results in decreased expression of SEPTIN11 mRNA CTD PMID:17374397 NCBI chr14:14,844,759...14,990,856
Ensembl chr14:14,844,580...14,990,853 		JBrowse link
G Serpinb3 serpin family B member 3 increases expression ISO Eugenol results in increased expression of SERPINB3 mRNA CTD PMID:30806763 NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682 		JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 decreases expression ISO Eugenol results in decreased expression of SLAMF1 mRNA CTD PMID:20713136 NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497 		JBrowse link
G Slc16a10 solute carrier family 16 member 10 increases expression ISO Eugenol results in increased expression of SLC16A10 mRNA CTD PMID:17374397 NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO Eugenol results in increased expression of SLC2A3 mRNA CTD PMID:17374397 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO
EXP		 Eugenol results in increased expression of SLC2A4 mRNA CTD PMID:20724125 PMID:21870829 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Eugenol results in increased expression of SLC7A11 mRNA CTD PMID:26198647 PMID:30806763 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
decreases expression
multiple interactions		 ISO Eugenol results in increased expression of SOD1 mRNA
Eugenol results in decreased expression of SOD1 mRNA; Eugenol results in decreased expression of SOD1 protein
Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]		 CTD PMID:16101137 PMID:20566472 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
decreases expression
multiple interactions		 ISO Eugenol results in increased expression of SOD2 mRNA
Eugenol results in decreased expression of SOD2 mRNA; Eugenol results in decreased expression of SOD2 protein
Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]		 CTD PMID:16101137 PMID:20566472 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 increases expression ISO Eugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Eugenol results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Eugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472 PMID:26198647 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Eugenol results in decreased expression of STAT1 mRNA CTD PMID:17374397 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 increases expression ISO Eugenol results in increased expression of STAT4 mRNA CTD PMID:17374397 NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases expression ISO Eugenol results in increased expression of STAT5B mRNA CTD PMID:17374397 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 increases sulfation ISO SULT1C1 protein results in increased sulfation of Eugenol CTD PMID:9560327 NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein] CTD PMID:20434464 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression ISO Eugenol results in increased expression of TLR4 mRNA CTD PMID:17936526 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
affects expression		 ISO
EXP		 Eugenol inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
Eugenol results in increased expression of TNF mRNA
Eugenol affects the expression of TNF mRNA
Eugenol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Eugenol inhibits the reaction [Thioacetamide results in increased activity of TNF protein]
[Methoxychlor co-treated with Eugenol] results in increased expression of TNF protein; [Parathion co-treated with Eugenol] results in increased expression of TNF protein; Eugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Bacterial Toxins results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of TNF protein]		 CTD PMID:10871845 PMID:12963494 PMID:17509409 PMID:20036707 PMID:20043298 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Eugenol results in increased expression of TNFAIP3 mRNA CTD PMID:20713136 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO Eugenol results in increased expression of TNFAIP6 mRNA CTD PMID:17374397 PMID:20713136 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases mutagenesis
increases expression		 EXP
ISO		 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TP53 protein]
Eugenol results in increased mutagenesis of TP53 gene
Eugenol results in increased expression of TRP53 mRNA; Eugenol results in increased expression of TRP53 protein
Eugenol promotes the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TRP53 protein]		 CTD PMID:15576237 PMID:19851710 PMID:20043298 PMID:20537511 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp63 tumor protein p63 decreases expression ISO Eugenol results in decreased expression of TP63 mRNA CTD PMID:17936526 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases activity		 EXP [2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide binds to and results in decreased activity of TRPA1 protein] which results in decreased susceptibility to Eugenol
Eugenol results in increased activity of TRPA1 protein		 CTD PMID:22426238 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 multiple interactions
increases activity		 ISO
EXP		 Eugenol binds to and results in increased activity of TRPV3 protein
[Eugenol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium; Eugenol binds to and results in increased activity of TRPV3 protein
[Eugenol results in increased activity of TRPV3 protein] which results in increased transport of Calcium		 CTD PMID:16617338 PMID:20086034 PMID:21593771 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
G Txn2 thioredoxin 2 increases expression ISO Eugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Eugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472 PMID:23445166 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO Eugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO Eugenol results in increased expression of UGDH mRNA CTD PMID:16292757 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Eugenol CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Eugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Eugenol CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases metabolic processing ISO UGT2B17 protein results in increased metabolism of Eugenol CTD PMID:8798464 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Eugenol CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
G Vdr vitamin D receptor increases expression ISO Eugenol results in increased expression of VDR mRNA CTD PMID:17374397 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Zbtb17 zinc finger and BTB domain containing 17 decreases expression ISO Eugenol results in decreased expression of ZBTB17 mRNA CTD PMID:17374397 NCBI chr 5:153,753,508...153,774,613
Ensembl chr 5:153,753,569...153,774,609 		JBrowse link
Formyl-N-acetyl-5-methoxykynurenamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapt microtubule-associated protein tau multiple interactions EXP N-acetyl-N-formyl-5-methoxykynurenamine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein] CTD PMID:31833155 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
gingerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO gingerol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:18385293 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein] CTD PMID:18577375 PMID:21851089 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] CTD PMID:27451028 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO gingerol results in increased expression of APAF1 mRNA; gingerol results in increased expression of APAF1 protein CTD PMID:19481070 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BAX protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BCL2 protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CASP3 protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of RELA protein]; gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TRP53 protein] CTD PMID:37121058 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein] CTD PMID:18577375 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [gingerol results in increased expression of BAX protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of BAX protein]
gingerol inhibits the reaction [hypoxia-reoxygenation increases expression of Bax protein in neural crest-derived cells]
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BAX protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of BAX protein]; gingerol inhibits the reaction [TNF protein results in increased expression of BAX protein]
gingerol results in increased expression of BAX mRNA; gingerol results in increased expression of BAX protein		 CTD
RGD		 PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 PMID:37121058 More... RGD:155882488 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO gingerol results in decreased expression of BCL2 mRNA; gingerol results in decreased expression of BCL2 protein
gingerol inhibits the reaction [hypoxia-reoxygenation decreases expression of Bcl2 protein in neural crest-derived cells]
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of BCL2 protein]
[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]		 CTD
RGD		 PMID:18030663 PMID:19481070 PMID:25034532 PMID:27451028 PMID:28249781 More... RGD:155882488 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO gingerol inhibits the reaction [hypoxia-reoxygenation decreases expression of Bdnf protein in neural crest-derived cells] RGD PMID:34962339 RGD:155882488 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO [gingerol co-treated with Hydrogen Peroxide] results in increased expression of BECN1 protein CTD PMID:27451028 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BID protein] CTD PMID:25034532 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BIRC5 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BIRC5 protein] CTD PMID:18030663 PMID:25034532 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
multiple interactions
affects activity		 ISO
EXP		 gingerol results in increased expression of CASP3 mRNA; gingerol results in increased expression of CASP3 protein
gingerol results in increased cleavage of CASP3 protein
gingerol inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein]
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CASP3 protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of CASP3 protein]
gingerol affects the activity of CASP3 protein
[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of CASP3 protein]		 CTD PMID:17454143 PMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
affects activity		 ISO [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]
gingerol results in increased cleavage of CASP8 protein
gingerol affects the activity of CASP8 protein		 CTD PMID:17454143 PMID:25034532 PMID:28249781 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression
increases cleavage
multiple interactions
affects activity		 ISO gingerol results in increased expression of CASP9 mRNA; gingerol results in increased expression of CASP9 protein
gingerol results in increased cleavage of CASP9 protein
gingerol inhibits the reaction [Testosterone results in decreased expression of CASP9 protein]
gingerol affects the activity of CASP9 protein		 CTD PMID:17454143 PMID:18030663 PMID:19481070 PMID:28249781 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 gingerol inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; gingerol inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]; gingerol inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
gingerol inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]		 CTD PMID:22285432 PMID:28373059 PMID:28421826 PMID:31004597 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO gingerol results in decreased expression of CCNB1 mRNA; gingerol results in decreased expression of CCNB1 protein CTD PMID:28249781 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression		 ISO [gingerol co-treated with Cycloheximide] results in increased degradation of CCND1 protein
gingerol results in increased expression of CCND1 mRNA; gingerol results in increased expression of CCND1 protein
gingerol results in decreased expression of CCND1 mRNA; gingerol results in decreased expression of CCND1 protein		 CTD PMID:18058799 PMID:26498061 PMID:28249781 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO gingerol results in decreased expression of CCNE1 mRNA; gingerol results in decreased expression of CCNE1 protein CTD PMID:28249781 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO gingerol results in decreased expression of CDK1 mRNA CTD PMID:28249781 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO gingerol results in decreased expression of CDK4 protein CTD PMID:18058799 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO gingerol results in decreased expression of CDKN1A mRNA CTD PMID:28249781 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO gingerol results in decreased expression of CDKN1B mRNA CTD PMID:28249781 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
multiple interactions		 ISO gingerol results in decreased expression of CEBPA mRNA; gingerol results in decreased expression of CEBPA protein
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]		 CTD PMID:26498061 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein] CTD PMID:25034532 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of CHEK2 protein] CTD PMID:28988496 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Ctnnb1 catenin beta 1 affects localization
increases expression
multiple interactions		 ISO gingerol affects the localization of CTNNB1 protein
gingerol results in increased expression of CTNNB1 mRNA
gingerol results in increased expression of and affects the localization of CTNNB1 protein
gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein]		 CTD PMID:18058799 PMID:26498061 PMID:27645308 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases response to substance ISO CYP2C19 mRNA results in increased susceptibility to gingerol CTD PMID:29555536 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO gingerol results in increased expression of DUSP10 mRNA CTD PMID:17151092 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dvl2 dishevelled segment polarity protein 2 increases expression ISO gingerol results in increased expression of DVL2 mRNA CTD PMID:26498061 NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820 		JBrowse link
G Fas Fas cell surface death receptor affects activity ISO gingerol affects the activity of FAS protein CTD PMID:17454143 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO gingerol results in decreased expression of FASN mRNA; gingerol results in decreased expression of FASN protein CTD PMID:26498061 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO gingerol inhibits the reaction [Glucose results in increased secretion of FN1 protein] CTD PMID:21829520 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of FSHB protein] CTD PMID:28421826 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions		 ISO gingerol results in increased expression of GDF15 mRNA; gingerol results in increased expression of GDF15 protein
GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]; PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]; Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein]		 CTD PMID:18058799 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases response to substance
increases phosphorylation
increases expression		 ISO gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]
GSK3B protein results in increased susceptibility to gingerol
GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
gingerol results in increased phosphorylation of GSK3B protein
gingerol results in increased expression of GSK3B protein		 CTD PMID:18058799 PMID:26498061 PMID:27645308 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] CTD PMID:21382473 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A decreases activity ISO gingerol results in decreased activity of HTR3A protein CTD PMID:26456648 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO gingerol inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; gingerol inhibits the reaction [IL1B protein results in increased phosphorylation of GSK3B protein]; gingerol promotes the reaction [IL1B protein results in increased expression of CTNNB1 protein]
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]		 CTD PMID:27645308 PMID:28421826 PMID:31004597 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA] CTD PMID:22285432 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO gingerol inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of INS1 protein]; gingerol inhibits the reaction [sodium arsenite results in decreased secretion of INS1 protein] CTD PMID:21851089 PMID:22285432 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:22285432 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of IRS2 protein] CTD PMID:22285432 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:18577375 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klkb1 kallikrein B1 multiple interactions
decreases expression		 ISO gingerol inhibits the reaction [Testosterone results in increased expression of KLKB1 protein]
gingerol results in decreased expression of KLKB1 protein		 CTD PMID:18030663 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Lats1 large tumor suppressor kinase 1 increases expression ISO gingerol results in increased expression of LATS1 protein CTD PMID:32926756 NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640 		JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions ISO gingerol inhibits the reaction [Dextran Sulfate results in increased activity of LDHC protein] CTD PMID:28421826 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378 		JBrowse link
G Lep leptin multiple interactions ISO gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA]; gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21851089 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO gingerol inhibits the reaction [Dextran Sulfate results in decreased expression of LHB protein] CTD PMID:28421826 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lrp6 LDL receptor related protein 6 increases expression ISO gingerol results in increased expression of LRP6 mRNA CTD PMID:26498061 NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [gingerol co-treated with Hydrogen Peroxide] results in increased expression of MAP1LC3B protein modified form CTD PMID:27451028 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein] CTD PMID:18577375 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mir210 microRNA 210 multiple interactions ISO gingerol inhibits the reaction [hypoxia-reoxygenation increases expression of Mir210 miRNA in neural crest-derived cells] RGD PMID:34962339 RGD:155882488 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
decreases activity		 ISO gingerol results in decreased expression of MMP2 mRNA; gingerol results in decreased expression of MMP2 protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein]
gingerol results in decreased activity of MMP2 protein		 CTD PMID:17683926 PMID:32926756 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
decreases activity		 ISO gingerol results in decreased expression of MMP9 mRNA
gingerol results in decreased activity of MMP9 protein		 CTD PMID:17683926 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP
ISO		 gingerol inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein]
gingerol inhibits the reaction [Benzo(a)pyrene results in increased activity of MPO protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]		 CTD PMID:28373059 PMID:28421826 PMID:31004597 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression		 ISO gingerol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MTOR protein]
gingerol results in decreased expression of MTOR protein modified form		 CTD PMID:27451028 PMID:28249781 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:18683823 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO gingerol affects the phosphorylation of and affects the activity of NFKBIA protein CTD PMID:17454143 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; gingerol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] CTD PMID:18683823 PMID:31004597 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein] CTD PMID:25034532 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression		 ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of PPARG protein]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG mRNA]; GSK3B protein promotes the reaction [gingerol results in decreased expression of PPARG protein]
gingerol results in decreased expression of PPARG mRNA; gingerol results in decreased expression of PPARG protein		 CTD PMID:22285432 PMID:26498061 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein] CTD PMID:18058799 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Ptges prostaglandin E synthase decreases expression
increases expression		 ISO gingerol results in decreased expression of PTGES protein
gingerol results in increased expression of PTGES mRNA		 CTD PMID:27645308 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression
multiple interactions		 ISO gingerol affects the expression of PTGS2 mRNA; gingerol affects the expression of PTGS2 protein
gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]; gingerol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]		 CTD PMID:17454143 PMID:18683823 PMID:31004597 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO gingerol results in decreased phosphorylation of RB1 protein CTD PMID:18058799 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression
multiple interactions
affects localization		 ISO gingerol affects the expression of RELA protein
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of RELA protein]; gingerol inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; gingerol inhibits the reaction [TNF protein results in increased expression of RELA protein]
gingerol affects the localization of RELA protein		 CTD PMID:17454143 PMID:18683823 PMID:37121058 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO gingerol results in decreased expression of RPS6KB1 protein modified form CTD PMID:28249781 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 mRNA]; gingerol inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein] CTD PMID:22285432 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO gingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA] CTD PMID:21829520 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression
multiple interactions		 ISO gingerol results in decreased expression of SNAI2 protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein]		 CTD PMID:32926756 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] CTD PMID:21382473 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO gingerol inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; gingerol inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA] CTD PMID:21382473 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 gingerol inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; gingerol inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of ADIPOQ mRNA]; gingerol inhibits the reaction [TNF protein results in decreased expression of and results in decreased secretion of ADIPOQ protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of BAX protein]; gingerol inhibits the reaction [TNF protein results in increased expression of CASP3 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of RELA protein]; gingerol inhibits the reaction [TNF protein results in increased expression of TRP53 protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of ATF2 protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; gingerol inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K4 protein]
gingerol inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]		 CTD PMID:18577375 PMID:21851089 PMID:22285432 PMID:28373059 PMID:28421826 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance		 ISO [gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein; [TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein] CTD PMID:25034532 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO gingerol results in increased expression of TP53 protein
gingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TRP53 protein]; gingerol inhibits the reaction [Testosterone results in decreased expression of TRP53 protein]; gingerol inhibits the reaction [TNF protein results in increased expression of TRP53 protein]
[gingerol results in increased expression of TP53 protein] which results in increased susceptibility to TNFSF10 protein; [Testosterone co-treated with gingerol] results in increased expression of TP53 protein; gingerol inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of TP53 protein]; TP53 protein affects the reaction [gingerol results in increased expression of TNFRSF10B protein]; TP53 protein affects the reaction [gingerol results in increased susceptibility to TNFSF10 protein]		 CTD PMID:18030663 PMID:25034532 PMID:28988496 PMID:37121058 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 ISO gingerol results in decreased expression of VIM protein
gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein]		 CTD PMID:32926756 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO gingerol results in decreased expression of XIAP protein CTD PMID:25034532 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator affects localization
multiple interactions		 ISO gingerol affects the localization of YAP1 protein
[gingerol co-treated with YAP1 protein] results in increased phosphorylation of YAP1 protein; gingerol inhibits the reaction [YAP1 protein results in increased expression of MMP2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of SNAI2 protein]; gingerol inhibits the reaction [YAP1 protein results in increased expression of VIM protein]; gingerol results in decreased expression of and results in increased phosphorylation of YAP1 protein		 CTD PMID:32926756 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
guaiacol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Guaiacol binds to ALB protein CTD PMID:11334365 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Guaiacol results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Guaiacol results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO COMT mutant form inhibits the reaction [catechol results in increased abundance of Guaiacol] CTD PMID:24141029 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Guaiacol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:17465205 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 increases sulfation ISO SULT1C1 protein results in increased sulfation of Guaiacol CTD PMID:9560327 NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030 		JBrowse link
homovanillic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp9 aquaporin 9 multiple interactions ISO AQP9 gene mutant form inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased abundance of Homovanillic Acid] CTD PMID:29566083 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO
EXP		 [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid CTD PMID:11793163 PMID:15190105 PMID:16012872 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Maob monoamine oxidase B multiple interactions EXP [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Acid CTD PMID:16012872 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO NOS1 protein affects the reaction [Methamphetamine results in decreased abundance of Homovanillic Acid] CTD PMID:11085313 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases abundance ISO NR3C1 protein results in increased abundance of Homovanillic Acid CTD PMID:11226678 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid] CTD PMID:8884884 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased abundance of Homovanillic Acid CTD PMID:10318960 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sct secretin increases abundance ISO SCT protein results in increased abundance of Homovanillic Acid CTD PMID:16168596 NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP Homovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Tfam transcription factor A, mitochondrial decreases abundance ISO TFAM gene mutant form results in decreased abundance of Homovanillic Acid CTD PMID:28595911 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Vdr vitamin D receptor multiple interactions
increases abundance		 ISO Calcitriol promotes the reaction [VDR protein results in increased abundance of Homovanillic Acid] CTD PMID:27450565 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
isoeugenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
affects localization
multiple interactions		 ISO isoeugenol results in increased activity of AHR protein
isoeugenol affects the localization of AHR protein
3'-methoxy-4'-nitroflavone inhibits the reaction [isoeugenol results in increased activity of AHR protein]		 CTD PMID:16972787 PMID:22686307 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO isoeugenol results in increased expression of AHRR mRNA CTD PMID:22686307 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases expression ISO isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO isoeugenol results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO isoeugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression
increases activity		 ISO isoeugenol results in increased expression of AKR1C2 mRNA
isoeugenol results in increased activity of AKR1C2 promoter		 CTD PMID:20491607 PMID:21195160 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO isoeugenol results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Ar androgen receptor affects binding EXP isoeugenol binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO isoeugenol results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Cat catalase increases expression ISO isoeugenol results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases secretion ISO isoeugenol results in decreased secretion of CCL2 protein CTD PMID:20488241 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl27 C-C motif chemokine ligand 27 increases expression ISO isoeugenol results in increased expression of CCL27 mRNA CTD PMID:17936526 NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506 		JBrowse link
G Cd274 CD274 molecule increases expression ISO isoeugenol results in increased expression of CD274 protein CTD PMID:20488241 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO isoeugenol results in decreased expression of CDK6 protein CTD PMID:22686307 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO isoeugenol results in increased expression of CDKN1B protein CTD PMID:22686307 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO isoeugenol results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO isoeugenol results in increased expression of CYP1A1 mRNA CTD PMID:20491607 PMID:22686307 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO isoeugenol results in increased expression of DNAJB4 mRNA CTD PMID:23999411 PMID:27965148 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Fech ferrochelatase increases expression ISO isoeugenol results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO isoeugenol results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO isoeugenol results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO isoeugenol results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO isoeugenol results in increased expression of GCLM mRNA CTD PMID:20566472 PMID:23999411 PMID:27965148 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO isoeugenol results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO isoeugenol results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isoeugenol results in increased expression of HMOX1 mRNA CTD PMID:20491607 PMID:20566472 PMID:23445166 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO isoeugenol results in increased expression of HSPA6 mRNA CTD PMID:23999411 NCBI chr13:83,273,176...83,274,317 JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO isoeugenol results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Ifng interferon gamma increases secretion ISO isoeugenol results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il18 interleukin 18 increases expression ISO isoeugenol results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO isoeugenol results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il2 interleukin 2 multiple interactions
increases secretion		 ISO isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; isoeugenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]
isoeugenol results in increased secretion of IL2 protein		 CTD PMID:17630204 PMID:22245253 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 increases secretion ISO isoeugenol results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO isoeugenol results in increased expression of MAFF mRNA CTD PMID:20491607 PMID:20566472 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO isoeugenol results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO isoeugenol results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO isoeugenol results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO isoeugenol results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:10871845 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; isoeugenol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; MAPK1 protein affects the reaction [isoeugenol affects the expression of NOS2]; MAPK3 protein affects the reaction [isoeugenol affects the expression of NOS2]; NFKBIA protein affects the reaction [isoeugenol affects the expression of NOS2] CTD PMID:17698059 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO isoeugenol results in increased expression of NQO1 mRNA CTD PMID:20491607 PMID:20566472 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Or5d18 olfactory receptor family 5 subfamily D member 18 multiple interactions ISO isoeugenol binds to and results in decreased activity of OR5D18 protein; isoeugenol binds to and results in increased activity of OR5D18 protein CTD PMID:15574817 PMID:21142015 NCBI chr 3:73,516,522...73,517,463
Ensembl chr 3:73,516,364...73,519,858
Ensembl chr 3:73,516,364...73,519,858 		JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO isoeugenol results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO isoeugenol results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO isoeugenol results in decreased expression of RB1 protein CTD PMID:22686307 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]		 CTD PMID:10871845 PMID:17698059 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression
multiple interactions		 ISO isoeugenol results in increased expression of SOCS3 mRNA; isoeugenol results in increased expression of SOCS3 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA]		 CTD PMID:21969073 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO isoeugenol results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO isoeugenol results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 increases expression ISO isoeugenol results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO isoeugenol results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO isoeugenol results in increased expression of TLR2 mRNA CTD PMID:17936526 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion		 ISO isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]
isoeugenol results in increased secretion of TNF protein		 CTD PMID:10871845 PMID:22245253 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trim16 tripartite motif-containing 16 multiple interactions
increases expression		 ISO [Indomethacin co-treated with isoeugenol] results in increased expression of TRIM16 mRNA
isoeugenol results in increased expression of TRIM16 mRNA		 CTD PMID:21284934 NCBI chr10:47,485,982...47,509,010
Ensembl chr10:47,486,297...47,551,907 		JBrowse link
G Txn2 thioredoxin 2 increases expression ISO isoeugenol results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO isoeugenol results in increased expression of TXNRD1 mRNA CTD PMID:20566472 PMID:23445166 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO isoeugenol results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO isoeugenol results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Zfp36 zinc finger protein 36 increases expression
multiple interactions		 ISO isoeugenol results in increased expression of ZFP36 protein
KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]; SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein]		 CTD PMID:21969073 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
isorhapontigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP isorhapontigenin inhibits the reaction [AGT protein results in increased abundance of Hydrogen Peroxide]; isorhapontigenin inhibits the reaction [AGT protein results in increased abundance of Malondialdehyde]; isorhapontigenin inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK8 protein] CTD PMID:15607907 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO isorhapontigenin results in decreased expression of CCND1 protein CTD PMID:37619952 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in increased expression of CDH1 protein CTD PMID:37619952 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] inhibits the reaction [CTNNB1 protein modified form binds to NEDD9 protein]; [sodium bichromate co-treated with isorhapontigenin] results in decreased localization of CTNNB1 protein; [sodium bichromate co-treated with isorhapontigenin] results in decreased phosphorylation of CTNNB1 protein CTD PMID:37619952 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of DNMT1 protein CTD PMID:37619952 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of DNMT3A protein CTD PMID:37619952 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of DNMT3B protein CTD PMID:37619952 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression EXP isorhapontigenin affects the expression of FOS protein CTD PMID:15607907 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in increased phosphorylation of GSK3B protein CTD PMID:37619952 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects activity EXP isorhapontigenin affects the activity of IKBKB protein CTD PMID:15607907 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression EXP isorhapontigenin affects the expression of JUN protein CTD PMID:15607907 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:15607907 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:15607907 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP isorhapontigenin inhibits the reaction [AGT protein results in increased phosphorylation of MAPK8 protein] CTD PMID:15607907 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Meg3 maternally expressed 3 multiple interactions ISO isorhapontigenin inhibits the reaction [sodium bichromate results in decreased expression of MEG3] CTD PMID:37619952 NCBI chr 6:128,491,808...128,524,010 JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO isorhapontigenin results in decreased expression of MKI67 protein CTD PMID:37619952 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] inhibits the reaction [CTNNB1 protein modified form binds to NEDD9 protein]; [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of and results in decreased localization of NEDD9 protein; [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of NEDD9 mRNA CTD PMID:37619952 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP isorhapontigenin affects the degradation of and affects the phosphorylation of NFKBIA protein CTD PMID:15607907 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO [sodium bichromate co-treated with isorhapontigenin] results in decreased expression of SNAI2 protein CTD PMID:37619952 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
isosilybin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases expression		 ISO isosilybin inhibits the reaction [T0901317 results in increased expression of ACACA mRNA]
isosilybin results in decreased expression of ACACA mRNA		 CTD PMID:36347319 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO isosilybin results in increased expression of ACOX1 mRNA CTD PMID:36347319 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CD36 mRNA] CTD PMID:36347319 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO isosilybin promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CPT1A mRNA] CTD PMID:36347319 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Fas Fas cell surface death receptor decreases expression
multiple interactions		 ISO isosilybin results in decreased expression of FAS mRNA
isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FAS protein]		 CTD PMID:36347319 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of MTTP mRNA]; isosilybin inhibits the reaction [T0901317 results in decreased expression of MTTP mRNA] CTD PMID:36347319 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 decreases expression
multiple interactions		 ISO isosilybin results in decreased expression of PNPLA3 mRNA
isosilybin inhibits the reaction [T0901317 results in increased expression of PNPLA3 mRNA]		 CTD PMID:36347319 NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA]; isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA protein] CTD PMID:36347319 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
multiple interactions		 ISO isosilybin results in decreased expression of SREBF1 mRNA
isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 protein]; isosilybin inhibits the reaction [T0901317 results in increased expression of SREBF1 mRNA]; isosilybin inhibits the reaction [T0901317 results in increased expression of SREBF1 protein]		 CTD PMID:36347319 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
KN-93 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein] CTD PMID:19647009 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Aco1 aconitase 1 multiple interactions EXP KN 93 inhibits the reaction [Cadmium Chloride affects the localization of ACO1 protein] CTD PMID:25106854 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein] CTD PMID:32522522 NCBI chr 8:20