metalloporphyrin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	metalloporphyrin	go back to main search page
Accession:	CHEBI:25216	browse the term
Synonyms:	related_synonym:	metalloporphyrins; metaloporphyrins

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Rat (348 ) Mouse (353 ) Human (360 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (2 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (348)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutamic-oxaloacetic transaminase 1

increases expression

EXP

Chlorophyll results in increased expression of GOT1 protein

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

increases activity

EXP

Chlorophyll results in increased activity of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

decreases expression

EXP

Chlorophyll A results in decreased expression of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

glutamic--pyruvic transaminase

increases expression

EXP

Chlorophyll A results in increased expression of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

nitric oxide synthase 3

increases expression

EXP

Chlorophyll A results in increased expression of NOS3 protein

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

superoxide dismutase 1

decreases expression

EXP

Chlorophyll A results in decreased expression of SOD1 protein

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

vascular endothelial growth factor A

increases expression

EXP

Chlorophyll A results in increased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 6

increases expression

ISO

Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein

NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526

G

adrenoceptor alpha 1A

increases expression

ISO

Heme metabolite results in increased expression of ADRA1A mRNA

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

5'-aminolevulinate synthase 1

decreases expression
multiple interactions

ISO

Heme results in decreased expression of ALAS1 protein
MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

5'-aminolevulinate synthase 2

decreases expression

ISO

Heme metabolite results in decreased expression of ALAS2 mRNA

NCBI chr X:22,890,650...22,914,046
Ensembl chr X:22,890,689...22,914,043

G

albumin

affects binding
multiple interactions

ISO

Heme binds to ALB protein
abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

alpha-1-microglobulin/bikunin precursor

increases expression

ISO

Heme results in increased expression of AMBP mRNA

NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:81,583,622...81,593,850

G

amyloid beta precursor protein

affects binding
multiple interactions

ISO

APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

Rho GTPase activating protein 31

decreases expression

ISO

Heme metabolite results in decreased expression of ARHGAP31 mRNA

NCBI chr11:75,544,176...75,657,087
Ensembl chr11:75,544,040...75,661,076

G

ankyrin repeat and SOCS box-containing 1

increases expression

ISO

Heme metabolite results in increased expression of ASB1 mRNA

NCBI chr 9:99,566,852...99,588,321
Ensembl chr 9:99,567,867...99,583,907

G

ASXL transcriptional regulator 2

decreases expression

ISO

Heme metabolite results in decreased expression of ASXL2 mRNA

NCBI chr 6:32,090,497...32,234,487
Ensembl chr 6:32,145,607...32,227,851

G

ATPase copper transporting beta

multiple interactions

ISO

ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme]

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801

G

BCAR3 adaptor protein, NSP family member

increases expression

ISO

Heme metabolite results in increased expression of BCAR3 mRNA

NCBI chr 2:213,209,907...213,323,305
Ensembl chr 2:213,209,893...213,323,302

G

biliverdin reductase A

increases expression

ISO

Heme metabolite results in increased expression of BLVRA mRNA

NCBI chr 3:134,793,397...134,819,367
Ensembl chr 3:134,794,203...134,819,785

G

BCL2 family apoptosis regulator BOK

decreases expression

ISO

Heme metabolite results in decreased expression of BOK mRNA

NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:101,670,625...101,681,833

G

carbonic anhydrase 1

multiple interactions
increases expression

EXP

[Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA

NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

ISO

Heme metabolite results in decreased expression of CAMK2B mRNA

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calcium/calmodulin-dependent protein kinase II gamma

decreases expression

ISO

Heme metabolite results in decreased expression of CAMK2G mRNA

NCBI chr15:3,553,238...3,612,310
Ensembl chr15:3,553,294...3,612,310

G

C-C motif chemokine ligand 2

increases expression

ISO

Heme metabolite results in increased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

increases secretion

ISO

Heme analog results in increased secretion of CCL3 protein

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 9

increases expression

ISO

Heme metabolite results in increased expression of CCL6 mRNA

NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,863,995...68,868,877

G

copper chaperone for superoxide dismutase

multiple interactions

ISO

[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]

NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:211,542,701...211,564,260

G

Cd2 molecule

increases expression

ISO

Heme metabolite results in increased expression of CD2 mRNA

NCBI chr 2:191,399,510...191,412,659
Ensembl chr 2:191,399,510...191,413,665

G

carboxyl ester lipase

decreases expression
multiple interactions

EXP

Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA

NCBI chr 3:32,281,518...32,289,019
Ensembl chr 3:32,281,518...32,289,019

G

chloride channel accessory 1

decreases expression

EXP

Heme results in decreased expression of CLCA1 mRNA

NCBI chr 2:236,599,022...236,624,714
Ensembl chr 2:236,599,022...236,624,714

G

CCR4-NOT transcription complex subunit 9

increases expression

ISO

Heme metabolite results in increased expression of CNOT9 mRNA

NCBI chr 9:83,533,369...83,558,207
Ensembl chr 9:83,533,369...83,558,197

G

COP9 signalosome subunit 5

increases expression

ISO

Heme metabolite results in increased expression of COPS5 mRNA

NCBI chr 5:13,975,198...13,993,391
Ensembl chr 5:13,975,052...13,993,387

G

coproporphyrinogen oxidase

increases chemical synthesis

ISO

CPOX protein results in increased chemical synthesis of Heme

NCBI chr11:55,405,778...55,415,761
Ensembl chr11:55,405,784...55,415,761

G

colony stimulating factor 2

decreases expression

ISO

Heme metabolite results in decreased expression of CSF2 mRNA

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

C-X-C motif chemokine ligand 2

increases expression

ISO

Heme metabolite results in increased expression of CXCL2 mRNA

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

cytochrome b5 type A

multiple interactions

ISO

[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]

NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

ISO

[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DGCR8 microprocessor complex subunit

affects binding

ISO

DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme

NCBI chr11:96,208,959...96,241,560
Ensembl chr11:96,209,038...96,241,551

G

DnaJ heat shock protein family (Hsp40) member C7

decreases expression

EXP

Heme results in decreased expression of DNAJC7 mRNA

NCBI chr10:86,018,977...86,055,419
Ensembl chr10:86,018,961...86,055,489

G

delta/notch-like EGF repeat containing

decreases expression

ISO

Heme metabolite results in decreased expression of DNER mRNA

NCBI chr 9:93,035,108...93,350,568
Ensembl chr 9:93,035,108...93,350,568

G

dual specificity phosphatase 14

increases expression

ISO

Heme metabolite results in increased expression of DUSP14 mRNA

NCBI chr10:69,433,949...69,463,863
Ensembl chr10:69,426,730...69,462,837

G

dual specificity phosphatase 2

decreases expression

ISO

Heme metabolite results in decreased expression of DUSP2 mRNA

NCBI chr 3:135,009,636...135,011,821
Ensembl chr 3:135,009,590...135,011,809

G

eukaryotic translation initiation factor 2 subunit gamma

decreases expression

ISO

Heme metabolite results in decreased expression of EIF2S3X mRNA

NCBI chr X:62,910,292...62,933,936
Ensembl chr X:62,910,293...62,934,489

G

enolase 2

increases expression

ISO

Heme metabolite results in increased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

epiregulin

increases expression

ISO

Heme metabolite results in increased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260

G

estrogen related receptor, alpha

decreases expression

ISO

Heme metabolite results in decreased expression of ESRRA mRNA

NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811

G

coagulation factor X

increases expression

ISO

Heme metabolite results in increased expression of F10 mRNA

NCBI chr16:83,170,973...83,190,280
Ensembl chr16:83,170,977...83,190,280

G

coagulation factor III, tissue factor

increases expression
multiple interactions

ISO

Heme results in increased expression of F3 mRNA
Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

fatty acid binding protein 2

multiple interactions
increases expression

EXP

[Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA
Heme results in increased expression of FABP2 mRNA

NCBI chr 2:213,724,629...213,728,686
Ensembl chr 2:213,724,629...213,728,686

G

fatty acid binding protein 3

increases expression

ISO

Heme metabolite results in increased expression of FABP3 mRNA

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

ISO

Heme metabolite results in decreased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FXYD domain-containing ion transport regulator 4

decreases expression

EXP

Heme results in decreased expression of FXYD4 mRNA

NCBI chr 4:152,782,181...152,786,118
Ensembl chr 4:152,782,181...152,786,039

G

Gfo/Idh/MocA-like oxidoreductase domain containing 1

decreases expression

ISO

Heme metabolite results in decreased expression of GFOD1 mRNA

NCBI chr17:21,606,090...21,710,922
Ensembl chr17:21,605,415...21,710,920

G

GIPC PDZ domain containing family, member 1

increases expression

ISO

Heme metabolite results in increased expression of GIPC1 mRNA

NCBI chr19:41,380,125...41,392,078
Ensembl chr19:41,380,125...41,391,725

G

G protein-coupled receptor 176

increases expression

ISO

Heme metabolite results in increased expression of GPR176 mRNA

NCBI chr 3:125,690,750...125,791,172
Ensembl chr 3:125,690,751...125,791,172

G

G protein-coupled receptor, class C, group 5, member A

increases expression

ISO

Heme metabolite results in increased expression of GPRC5A mRNA

NCBI chr 4:169,634,896...169,653,627
Ensembl chr 4:169,634,748...169,653,625

G

glutamic--pyruvic transaminase

increases expression

ISO

Heme metabolite results in increased expression of GPT mRNA

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

EXP

5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]

NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:169,716,709...169,779,737

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

ISO
EXP

Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]

PMID:19466990 PMID:22171090

NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:169,646,898...169,696,987

G

HECT domain E3 ubiquitin protein ligase 3

decreases expression

ISO

Heme metabolite results in decreased expression of HECTD3 mRNA

NCBI chr 5:135,706,437...135,715,173
Ensembl chr 5:135,706,473...135,714,421

G

hexokinase 3

increases expression

ISO

Heme metabolite results in increased expression of HK3 mRNA

NCBI chr17:9,602,119...9,620,038
Ensembl chr17:9,605,016...9,620,037

G

heme oxygenase 1

multiple interactions
increases degradation
increases metabolic processing
decreases expression
decreases abundance
increases expression

ISO
EXP

[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased metabolism of Heme
Heme results in decreased expression of HMOX1 mRNA
HMOX1 protein results in decreased abundance of Heme
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]

PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hemopexin

multiple interactions
affects binding

ISO

[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]

PMID:11213479 PMID:19039664

NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:169,344,583...169,352,156

G

interferon gamma

multiple interactions

ISO

Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 alpha

increases expression

ISO

Heme metabolite results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions
increases secretion

ISO

Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein

PMID:11076874 PMID:23355332

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor-like 1

decreases expression

ISO

Heme metabolite results in decreased expression of IL1RL1 mRNA

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891

G

interleukin 20

increases expression

ISO

Heme metabolite results in increased expression of IL20 mRNA

NCBI chr13:44,933,249...44,936,893
Ensembl chr13:44,933,249...44,936,893

G

interleukin 6

increases expression
multiple interactions

ISO

Heme results in increased expression of IL6 mRNA; Heme results in increased expression of IL6 protein
LY96 protein promotes the reaction [Heme results in increased expression of IL6 mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 7 receptor

increases expression

ISO

Heme metabolite results in increased expression of IL7R mRNA

NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:60,181,382...60,211,027

G

interferon regulatory factor 3

decreases expression

ISO

Heme metabolite results in decreased expression of IRF3 mRNA

NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401

G

interferon regulatory factor 4

increases expression

ISO

Heme metabolite results in increased expression of IRF4 mRNA

NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,930,471...33,948,730

G

intelectin 1

decreases expression

EXP

Heme results in decreased expression of ITLN1 mRNA

NCBI chr13:86,464,641...86,490,655
Ensembl chr13:86,464,669...86,490,651

G

keratin 20

increases expression

EXP

Heme results in increased expression of KRT20 mRNA

NCBI chr10:84,880,952...84,890,285
Ensembl chr10:84,880,952...84,890,285

G

lymphocyte antigen 96

affects binding
multiple interactions

ISO

Heme binds to LY96 protein
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to LY96 protein]]; Heme promotes the reaction [TLR4 protein binds to LY96 protein]; LY96 protein promotes the reaction [Heme results in decreased localization of NFKBIA protein]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 protein]; LY96 protein promotes the reaction [Heme results in increased expression of TNF mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of TNF protein]; LY96 protein promotes the reaction [Heme results in increased localization of RELA protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK1 protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK3 protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK8 protein]

NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:7,365,557...7,395,816

G

lysozyme 2

multiple interactions
increases secretion

ISO

SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein]

NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

ISO

Heme results in increased phosphorylation of MAPK1 protein
LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

ISO

Heme results in increased phosphorylation of MAPK3 protein
LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

ISO

Heme results in increased phosphorylation of MAPK8 protein
LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

myeloperoxidase

multiple interactions

EXP

Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mucosal pentraxin 1

decreases expression
multiple interactions

EXP

Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]

NCBI chr13:88,260,335...88,263,869
Ensembl chr13:88,260,335...88,263,869

G

MRE11 homolog, double strand break repair nuclease

decreases expression

ISO

Heme metabolite results in decreased expression of MRE11A mRNA

NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:19,913,772...19,961,904

G

metallothionein 1A

decreases response to substance
multiple interactions

ISO

MT1A protein results in decreased susceptibility to Heme
[Heme co-treated with HPX protein] affects the activity of MT1 promoter

PMID:11213479 PMID:11878821

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metal-regulatory transcription factor 1

multiple interactions

ISO

[Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]

NCBI chr 5:142,347,024...142,391,810
Ensembl chr 5:142,347,054...142,391,810

G

myotubularin related protein 10

increases expression

ISO

Heme metabolite results in increased expression of MTMR10 mRNA

NCBI chr 1:127,271,139...127,322,621
Ensembl chr 1:127,270,870...127,322,621

G

MYD88, innate immune signal transduction adaptor

multiple interactions

ISO

ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to MYD88 protein]]; Heme promotes the reaction [TLR4 protein binds to MYD88 protein]

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

affects localization

ISO

Heme analog affects the localization of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions
decreases localization

ISO

Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein
LY96 protein promotes the reaction [Heme results in decreased localization of NFKBIA protein]

PMID:23355332 PMID:36115635

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

neuroglobin

affects binding

ISO

Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein

NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:112,475,332...112,480,786

G

nitric oxide synthase 2

multiple interactions

ISO

Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

prolyl-tRNA synthetase 2, mitochondrial

decreases expression

ISO

Heme metabolite results in decreased expression of PARS2 mRNA

NCBI chr 5:126,662,882...126,667,981
Ensembl chr 5:126,657,700...126,676,455

G

proprotein convertase subtilisin/kexin type 2

increases expression

ISO

Heme metabolite results in increased expression of PCSK2 mRNA

NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:151,333,234...151,638,849

G

platelet derived growth factor subunit B

decreases expression

ISO

Heme metabolite results in decreased expression of PDGFB mRNA

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343

G

post-GPI attachment to proteins 2

decreases expression

ISO

Heme metabolite results in decreased expression of PGAP2 mRNA

NCBI chr 1:166,003,593...166,030,088
Ensembl chr 1:166,003,523...166,030,088

G

pleckstrin homology-like domain, family A, member 1

decreases expression

ISO

Heme metabolite results in decreased expression of PHLDA1 mRNA

NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542

G

praja ring finger ubiquitin ligase 2

decreases expression

ISO

Heme metabolite results in decreased expression of PJA2 mRNA

NCBI chr 9:111,403,624...111,453,703
Ensembl chr 9:111,403,624...111,453,703

G

pleckstrin homology and RUN domain containing M1

increases expression

ISO

Heme metabolite results in increased expression of PLEKHM1 mRNA

NCBI chr10:88,814,699...88,876,570
Ensembl chr10:88,814,699...88,862,544

G

pleckstrin homology domain containing O1

increases expression

ISO

Heme metabolite results in increased expression of PLEKHO1 mRNA

NCBI chr 2:186,233,435...186,242,114
Ensembl chr 2:186,233,452...186,241,354

G

polo-like kinase 2

increases expression

ISO

Heme metabolite results in increased expression of PLK2 mRNA

NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:43,701,865...43,708,296

G

plexin A2

increases expression

ISO

Heme metabolite results in increased expression of PLXNA2 mRNA

NCBI chr13:108,683,155...108,888,336
Ensembl chr13:108,691,530...108,887,453

G

protein-O-mannosyltransferase 1

decreases expression

ISO

Heme metabolite results in decreased expression of POMT1 mRNA

NCBI chr 3:35,918,370...35,936,330
Ensembl chr 3:35,918,188...35,936,364

G

cytochrome p450 oxidoreductase

multiple interactions

ISO

[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

peptidylprolyl isomerase E

increases expression

ISO

Heme metabolite results in increased expression of PPIE mRNA

NCBI chr 5:140,691,285...140,704,347
Ensembl chr 5:140,683,801...140,740,767

G

proline-serine-threonine phosphatase-interacting protein 2

increases expression

ISO

Heme metabolite results in increased expression of PSTPIP2 mRNA

NCBI chr18:73,585,729...73,671,868
Ensembl chr18:73,585,993...73,671,871

G

RAB33A, member RAS oncogene family

increases expression

ISO

Heme metabolite results in increased expression of RAB33A mRNA

NCBI chr X:132,572,133...132,584,255
Ensembl chr X:132,572,148...132,584,254

G

RAB3A, member RAS oncogene family

decreases expression

ISO

Heme metabolite results in decreased expression of RAB3A mRNA

NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,718,167...18,721,842

G

RNA binding motif protein 39

increases expression

ISO

Heme metabolite results in increased expression of RBM39 mRNA

NCBI chr 3:165,123,087...165,156,453
Ensembl chr 3:165,123,095...165,149,397

G

ring-box 1

increases expression

ISO

Heme metabolite results in increased expression of RBX1 mRNA

NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191

G

RELA proto-oncogene, NF-kB subunit

affects localization
increases localization
multiple interactions

ISO

Heme analog affects the localization of RELA protein
Heme results in increased localization of RELA protein
LY96 protein promotes the reaction [Heme results in increased localization of RELA protein]

PMID:23355332 PMID:36115635

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RHEB like 1

increases expression

ISO

Heme metabolite results in increased expression of RHEBL1 mRNA

NCBI chr 7:131,905,207...131,910,088
Ensembl chr 7:131,905,207...131,909,199

G

RNA polymerase II associated protein 1

decreases expression

ISO

Heme metabolite results in decreased expression of RPAP1 mRNA

NCBI chr 3:127,200,450...127,221,985
Ensembl chr 3:127,110,550...127,221,952

G

ribosomal protein S6 kinase A2

increases expression

ISO

Heme metabolite results in increased expression of RPS6KA2 mRNA

NCBI chr 1:55,178,988...55,454,271
Ensembl chr 1:55,179,319...55,454,338

G

RT1 class Ia, locus A2

increases expression

ISO

Heme metabolite results in increased expression of H2-T23 mRNA

NCBI chr20:4,872,720...4,876,425

G

RT1 class II, locus Bb

decreases expression

ISO

Heme metabolite results in decreased expression of H2-AB1 mRNA

NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118

G

RT1 class I, locus CE16

decreases expression

ISO

Heme metabolite results in decreased expression of H2-Q1 mRNA

NCBI chr20:3,261,656...3,265,548

G

SET domain bifurcated histone lysine methyltransferase 1

decreases expression

ISO

Heme metabolite results in decreased expression of SETDB1 mRNA

NCBI chr 2:185,587,722...185,619,084
Ensembl chr 2:185,587,722...185,618,982

G

SLAM family member 7

increases expression

ISO

Heme metabolite results in increased expression of SLAMF7 mRNA

NCBI chr13:86,668,060...86,688,222
Ensembl chr13:86,668,060...86,686,341

G

solute carrier family 46 member 1

multiple interactions
increases uptake

ISO

SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme

NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,859,504...63,866,869

G

SWI/SNF related BAF chromatin remodeling complex subunit B1

decreases expression

ISO

Heme metabolite results in decreased expression of SMARCB1 mRNA

NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,740,943...12,763,055

G

structural maintenance of chromosomes 4

decreases expression

ISO

Heme metabolite results in decreased expression of SMC4 mRNA

NCBI chr 2:155,550,262...155,578,695
Ensembl chr 2:155,550,262...155,581,937

G

signal recognition particle 9

increases expression

ISO

Heme metabolite results in increased expression of SRP9 mRNA

NCBI chr13:96,364,253...96,372,393
Ensembl chr13:96,364,298...96,373,257

G

StAR-related lipid transfer domain containing 4

increases expression

ISO

Heme metabolite results in increased expression of STARD4 mRNA

NCBI chr18:25,088,831...25,104,172
Ensembl chr18:25,091,255...25,104,172

G

TATA-box binding protein associated factor 7

increases expression

ISO

Heme metabolite results in increased expression of TAF7 mRNA

NCBI chr18:29,704,182...29,713,382
Ensembl chr18:29,705,920...29,712,712

G

tryptophan 2,3-dioxygenase

multiple interactions

EXP

Heme promotes the reaction [pyridine results in increased activity of TDO2 protein]

NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586

G

toll-like receptor 4

multiple interactions
affects binding

ISO

ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to LY96 protein]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to MYD88 protein]]; Heme promotes the reaction [TLR4 protein binds to LY96 protein]; Heme promotes the reaction [TLR4 protein binds to MYD88 protein]
Heme binds to TLR4 protein

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions
increases expression
increases secretion

ISO

Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
LY96 protein promotes the reaction [Heme results in increased expression of TNF mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of TNF protein]
Heme results in increased expression of TNF mRNA; Heme results in increased expression of TNF protein
Heme analog results in increased secretion of TNF protein

PMID:11076874 PMID:23355332 PMID:36115635

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF superfamily member 13b

decreases expression

ISO

Heme metabolite results in decreased expression of TNFSF13B mRNA

NCBI chr16:86,164,377...86,195,072
Ensembl chr16:86,164,377...86,194,499

G

toll interacting protein

increases expression

ISO

Heme metabolite results in increased expression of TOLLIP mRNA

NCBI chr 1:206,391,120...206,413,809
Ensembl chr 1:206,380,308...206,411,988

G

tubulin, alpha 4A

increases expression

ISO

Heme metabolite results in increased expression of TUBA4A mRNA

NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:84,158,280...84,162,584

G

ubiquitin-conjugating enzyme E2L 3

increases expression

ISO

Heme metabolite results in increased expression of UBE2L3 mRNA

NCBI chr11:97,300,584...97,343,084
Ensembl chr11:97,301,945...97,343,084

G

ubiquitin-conjugating enzyme E2R 2

decreases expression

ISO

Heme metabolite results in decreased expression of UBE2R2 mRNA

NCBI chr 5:61,082,552...61,141,099
Ensembl chr 5:61,082,552...61,141,452

G

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2

decreases expression

ISO

Heme metabolite results in decreased expression of WFIKKN2 mRNA

NCBI chr10:79,682,459...79,688,553
Ensembl chr10:79,682,459...79,688,553

G

YEATS domain containing 2

decreases expression

ISO

Heme metabolite results in decreased expression of YEATS2 mRNA

NCBI chr11:94,247,538...94,333,652
Ensembl chr11:94,247,538...94,333,292

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 6

increases expression

ISO

Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein

NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526

G

adrenoceptor alpha 1A

increases expression

ISO

Heme metabolite results in increased expression of ADRA1A mRNA

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534

G

5'-aminolevulinate synthase 1

multiple interactions
decreases expression

ISO

MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

5'-aminolevulinate synthase 2

decreases expression

ISO

Heme metabolite results in decreased expression of ALAS2 mRNA

NCBI chr X:22,890,650...22,914,046
Ensembl chr X:22,890,689...22,914,043

G

albumin

multiple interactions
affects binding

ISO

abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

alpha-1-microglobulin/bikunin precursor

increases expression

ISO

Heme results in increased expression of AMBP mRNA

NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:81,583,622...81,593,850

G

amyloid beta precursor protein

affects binding
multiple interactions

ISO

APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

Rho GTPase activating protein 31

decreases expression

ISO

Heme metabolite results in decreased expression of ARHGAP31 mRNA

NCBI chr11:75,544,176...75,657,087
Ensembl chr11:75,544,040...75,661,076

G

ankyrin repeat and SOCS box-containing 1

increases expression

ISO

Heme metabolite results in increased expression of ASB1 mRNA

NCBI chr 9:99,566,852...99,588,321
Ensembl chr 9:99,567,867...99,583,907

G

ASXL transcriptional regulator 2

decreases expression

ISO

Heme metabolite results in decreased expression of ASXL2 mRNA

NCBI chr 6:32,090,497...32,234,487
Ensembl chr 6:32,145,607...32,227,851

G

ATPase copper transporting beta

multiple interactions

ISO

ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme]

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801

G

BCAR3 adaptor protein, NSP family member

increases expression

ISO

Heme metabolite results in increased expression of BCAR3 mRNA

NCBI chr 2:213,209,907...213,323,305
Ensembl chr 2:213,209,893...213,323,302

G

biliverdin reductase A

increases expression

ISO

Heme metabolite results in increased expression of BLVRA mRNA

NCBI chr 3:134,793,397...134,819,367
Ensembl chr 3:134,794,203...134,819,785

G

BCL2 family apoptosis regulator BOK

decreases expression

ISO

Heme metabolite results in decreased expression of BOK mRNA

NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:101,670,625...101,681,833

G

carbonic anhydrase 1

multiple interactions
increases expression

EXP

[Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA

NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454

G

calcium/calmodulin-dependent protein kinase II beta

decreases expression

ISO

Heme metabolite results in decreased expression of CAMK2B mRNA

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calcium/calmodulin-dependent protein kinase II gamma

decreases expression

ISO

Heme metabolite results in decreased expression of CAMK2G mRNA

NCBI chr15:3,553,238...3,612,310
Ensembl chr15:3,553,294...3,612,310

G

C-C motif chemokine ligand 2

increases expression

ISO

Heme metabolite results in increased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

increases secretion

ISO

Heme analog results in increased secretion of CCL3 protein

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 9

increases expression

ISO

Heme metabolite results in increased expression of CCL6 mRNA

NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,863,995...68,868,877

G

copper chaperone for superoxide dismutase

multiple interactions

ISO

[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]

NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:211,542,701...211,564,260

G

Cd2 molecule

increases expression

ISO

Heme metabolite results in increased expression of CD2 mRNA

NCBI chr 2:191,399,510...191,412,659
Ensembl chr 2:191,399,510...191,413,665

G

carboxyl ester lipase

decreases expression
multiple interactions

EXP

Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA

NCBI chr 3:32,281,518...32,289,019
Ensembl chr 3:32,281,518...32,289,019

G

chloride channel accessory 1

decreases expression

EXP

Heme results in decreased expression of CLCA1 mRNA

NCBI chr 2:236,599,022...236,624,714
Ensembl chr 2:236,599,022...236,624,714

G

CCR4-NOT transcription complex subunit 9

increases expression

ISO

Heme metabolite results in increased expression of CNOT9 mRNA

NCBI chr 9:83,533,369...83,558,207
Ensembl chr 9:83,533,369...83,558,197

G

COP9 signalosome subunit 5

increases expression

ISO

Heme metabolite results in increased expression of COPS5 mRNA

NCBI chr 5:13,975,198...13,993,391
Ensembl chr 5:13,975,052...13,993,387

G

coproporphyrinogen oxidase

increases chemical synthesis

ISO

CPOX protein results in increased chemical synthesis of Heme

NCBI chr11:55,405,778...55,415,761
Ensembl chr11:55,405,784...55,415,761

G

colony stimulating factor 2

decreases expression

ISO

Heme metabolite results in decreased expression of CSF2 mRNA

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

C-X-C motif chemokine ligand 2

increases expression

ISO

Heme metabolite results in increased expression of CXCL2 mRNA

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

cytochrome b5 type A

multiple interactions

ISO

[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]

NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

ISO

[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DGCR8 microprocessor complex subunit

affects binding

ISO

DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme

NCBI chr11:96,208,959...96,241,560
Ensembl chr11:96,209,038...96,241,551

G

DnaJ heat shock protein family (Hsp40) member C7

decreases expression

EXP

Heme results in decreased expression of DNAJC7 mRNA

NCBI chr10:86,018,977...86,055,419
Ensembl chr10:86,018,961...86,055,489

G

delta/notch-like EGF repeat containing

decreases expression

ISO

Heme metabolite results in decreased expression of DNER mRNA

NCBI chr 9:93,035,108...93,350,568
Ensembl chr 9:93,035,108...93,350,568

G

dual specificity phosphatase 14

increases expression

ISO

Heme metabolite results in increased expression of DUSP14 mRNA

NCBI chr10:69,433,949...69,463,863
Ensembl chr10:69,426,730...69,462,837

G

dual specificity phosphatase 2

decreases expression

ISO

Heme metabolite results in decreased expression of DUSP2 mRNA

NCBI chr 3:135,009,636...135,011,821
Ensembl chr 3:135,009,590...135,011,809

G

eukaryotic translation initiation factor 2 subunit gamma

decreases expression

ISO

Heme metabolite results in decreased expression of EIF2S3X mRNA

NCBI chr X:62,910,292...62,933,936
Ensembl chr X:62,910,293...62,934,489

G

enolase 2

increases expression

ISO

Heme metabolite results in increased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

epiregulin

increases expression

ISO

Heme metabolite results in increased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260

G

estrogen related receptor, alpha

decreases expression

ISO

Heme metabolite results in decreased expression of ESRRA mRNA

NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811

G

coagulation factor X

increases expression

ISO

Heme metabolite results in increased expression of F10 mRNA

NCBI chr16:83,170,973...83,190,280
Ensembl chr16:83,170,977...83,190,280

G

coagulation factor III, tissue factor

multiple interactions
increases expression

ISO

Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

fatty acid binding protein 2

increases expression
multiple interactions

EXP

Heme results in increased expression of FABP2 mRNA
[Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA

NCBI chr 2:213,724,629...213,728,686
Ensembl chr 2:213,724,629...213,728,686

G

fatty acid binding protein 3

increases expression

ISO

Heme metabolite results in increased expression of FABP3 mRNA

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

ISO

Heme metabolite results in decreased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FXYD domain-containing ion transport regulator 4

decreases expression

EXP

Heme results in decreased expression of FXYD4 mRNA

NCBI chr 4:152,782,181...152,786,118
Ensembl chr 4:152,782,181...152,786,039

G

Gfo/Idh/MocA-like oxidoreductase domain containing 1

decreases expression

ISO

Heme metabolite results in decreased expression of GFOD1 mRNA

NCBI chr17:21,606,090...21,710,922
Ensembl chr17:21,605,415...21,710,920

G

GIPC PDZ domain containing family, member 1

increases expression

ISO

Heme metabolite results in increased expression of GIPC1 mRNA

NCBI chr19:41,380,125...41,392,078
Ensembl chr19:41,380,125...41,391,725

G

G protein-coupled receptor 176

increases expression

ISO

Heme metabolite results in increased expression of GPR176 mRNA

NCBI chr 3:125,690,750...125,791,172
Ensembl chr 3:125,690,751...125,791,172

G

G protein-coupled receptor, class C, group 5, member A

increases expression

ISO

Heme metabolite results in increased expression of GPRC5A mRNA

NCBI chr 4:169,634,896...169,653,627
Ensembl chr 4:169,634,748...169,653,625

G

glutamic--pyruvic transaminase

increases expression

ISO

Heme metabolite results in increased expression of GPT mRNA

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

EXP

5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]

NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:169,716,709...169,779,737

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

ISO
EXP

Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]

PMID:19466990 PMID:22171090

NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:169,646,898...169,696,987

G

HECT domain E3 ubiquitin protein ligase 3

decreases expression

ISO

Heme metabolite results in decreased expression of HECTD3 mRNA

NCBI chr 5:135,706,437...135,715,173
Ensembl chr 5:135,706,473...135,714,421

G

hexokinase 3

increases expression

ISO

Heme metabolite results in increased expression of HK3 mRNA

NCBI chr17:9,602,119...9,620,038
Ensembl chr17:9,605,016...9,620,037

G

heme oxygenase 1

decreases expression
multiple interactions
increases degradation
decreases abundance
increases metabolic processing
increases expression

ISO
EXP

Heme results in decreased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]
HMOX1 protein results in increased degradation of Heme
HMOX1 protein results in decreased abundance of Heme
HMOX1 protein results in increased metabolism of Heme
[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein

PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hemopexin

multiple interactions
affects binding

ISO

[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]

PMID:11213479 PMID:19039664

NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:169,344,583...169,352,156

G

interferon gamma

multiple interactions

ISO

Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 alpha

increases expression

ISO

Heme metabolite results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions
increases secretion

ISO

Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein

PMID:11076874 PMID:23355332

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor-like 1

decreases expression

ISO

Heme metabolite results in decreased expression of IL1RL1 mRNA

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891

G

interleukin 20

increases expression

ISO

Heme metabolite results in increased expression of IL20 mRNA

NCBI chr13:44,933,249...44,936,893
Ensembl chr13:44,933,249...44,936,893

G

interleukin 6

increases expression
multiple interactions

ISO

Heme results in increased expression of IL6 mRNA; Heme results in increased expression of IL6 protein
LY96 protein promotes the reaction [Heme results in increased expression of IL6 mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 7 receptor

increases expression

ISO

Heme metabolite results in increased expression of IL7R mRNA

NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:60,181,382...60,211,027

G

interferon regulatory factor 3

decreases expression

ISO

Heme metabolite results in decreased expression of IRF3 mRNA

NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401

G

interferon regulatory factor 4

increases expression

ISO

Heme metabolite results in increased expression of IRF4 mRNA

NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,930,471...33,948,730

G

intelectin 1

decreases expression

EXP

Heme results in decreased expression of ITLN1 mRNA

NCBI chr13:86,464,641...86,490,655
Ensembl chr13:86,464,669...86,490,651

G

keratin 20

increases expression

EXP

Heme results in increased expression of KRT20 mRNA

NCBI chr10:84,880,952...84,890,285
Ensembl chr10:84,880,952...84,890,285

G

lymphocyte antigen 96

affects binding
multiple interactions

ISO

Heme binds to LY96 protein
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to LY96 protein]]; Heme promotes the reaction [TLR4 protein binds to LY96 protein]; LY96 protein promotes the reaction [Heme results in decreased localization of NFKBIA protein]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 protein]; LY96 protein promotes the reaction [Heme results in increased expression of TNF mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of TNF protein]; LY96 protein promotes the reaction [Heme results in increased localization of RELA protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK1 protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK3 protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK8 protein]

NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:7,365,557...7,395,816

G

lysozyme 2

increases secretion
multiple interactions

ISO

Heme analog results in increased secretion of LYZ protein
SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein]

NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO

LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

ISO

Heme results in increased phosphorylation of MAPK3 protein
LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

ISO

LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

myeloperoxidase

multiple interactions

EXP

Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mucosal pentraxin 1

decreases expression
multiple interactions

EXP

Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]

NCBI chr13:88,260,335...88,263,869
Ensembl chr13:88,260,335...88,263,869

G

MRE11 homolog, double strand break repair nuclease

decreases expression

ISO

Heme metabolite results in decreased expression of MRE11A mRNA

NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:19,913,772...19,961,904

G

metallothionein 1A

decreases response to substance
multiple interactions

ISO

MT1A protein results in decreased susceptibility to Heme
[Heme co-treated with HPX protein] affects the activity of MT1 promoter

PMID:11213479 PMID:11878821

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metal-regulatory transcription factor 1

multiple interactions

ISO

[Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]

NCBI chr 5:142,347,024...142,391,810
Ensembl chr 5:142,347,054...142,391,810

G

myotubularin related protein 10

increases expression

ISO

Heme metabolite results in increased expression of MTMR10 mRNA

NCBI chr 1:127,271,139...127,322,621
Ensembl chr 1:127,270,870...127,322,621

G

MYD88, innate immune signal transduction adaptor

multiple interactions

ISO

ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to MYD88 protein]]; Heme promotes the reaction [TLR4 protein binds to MYD88 protein]

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

affects localization

ISO

Heme analog affects the localization of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions
decreases localization

ISO

Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein
LY96 protein promotes the reaction [Heme results in decreased localization of NFKBIA protein]

PMID:23355332 PMID:36115635

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

neuroglobin

affects binding

ISO

Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein

NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:112,475,332...112,480,786

G

nitric oxide synthase 2

multiple interactions

ISO

Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

prolyl-tRNA synthetase 2, mitochondrial

decreases expression

ISO

Heme metabolite results in decreased expression of PARS2 mRNA

NCBI chr 5:126,662,882...126,667,981
Ensembl chr 5:126,657,700...126,676,455

G

proprotein convertase subtilisin/kexin type 2

increases expression

ISO

Heme metabolite results in increased expression of PCSK2 mRNA

NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:151,333,234...151,638,849

G

platelet derived growth factor subunit B

decreases expression

ISO

Heme metabolite results in decreased expression of PDGFB mRNA

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343

G

post-GPI attachment to proteins 2

decreases expression

ISO

Heme metabolite results in decreased expression of PGAP2 mRNA

NCBI chr 1:166,003,593...166,030,088
Ensembl chr 1:166,003,523...166,030,088

G

pleckstrin homology-like domain, family A, member 1

decreases expression

ISO

Heme metabolite results in decreased expression of PHLDA1 mRNA

NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542

G

praja ring finger ubiquitin ligase 2

decreases expression

ISO

Heme metabolite results in decreased expression of PJA2 mRNA

NCBI chr 9:111,403,624...111,453,703
Ensembl chr 9:111,403,624...111,453,703

G

pleckstrin homology and RUN domain containing M1

increases expression

ISO

Heme metabolite results in increased expression of PLEKHM1 mRNA

NCBI chr10:88,814,699...88,876,570
Ensembl chr10:88,814,699...88,862,544

G

pleckstrin homology domain containing O1

increases expression

ISO

Heme metabolite results in increased expression of PLEKHO1 mRNA

NCBI chr 2:186,233,435...186,242,114
Ensembl chr 2:186,233,452...186,241,354

G

polo-like kinase 2

increases expression

ISO

Heme metabolite results in increased expression of PLK2 mRNA

NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:43,701,865...43,708,296

G

plexin A2

increases expression

ISO

Heme metabolite results in increased expression of PLXNA2 mRNA

NCBI chr13:108,683,155...108,888,336
Ensembl chr13:108,691,530...108,887,453

G

protein-O-mannosyltransferase 1

decreases expression

ISO

Heme metabolite results in decreased expression of POMT1 mRNA

NCBI chr 3:35,918,370...35,936,330
Ensembl chr 3:35,918,188...35,936,364

G

cytochrome p450 oxidoreductase

multiple interactions

ISO

[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

peptidylprolyl isomerase E

increases expression

ISO

Heme metabolite results in increased expression of PPIE mRNA

NCBI chr 5:140,691,285...140,704,347
Ensembl chr 5:140,683,801...140,740,767

G

proline-serine-threonine phosphatase-interacting protein 2

increases expression

ISO

Heme metabolite results in increased expression of PSTPIP2 mRNA

NCBI chr18:73,585,729...73,671,868
Ensembl chr18:73,585,993...73,671,871

G

RAB33A, member RAS oncogene family

increases expression

ISO

Heme metabolite results in increased expression of RAB33A mRNA

NCBI chr X:132,572,133...132,584,255
Ensembl chr X:132,572,148...132,584,254

G

RAB3A, member RAS oncogene family

decreases expression

ISO

Heme metabolite results in decreased expression of RAB3A mRNA

NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,718,167...18,721,842

G

RNA binding motif protein 39

increases expression

ISO

Heme metabolite results in increased expression of RBM39 mRNA

NCBI chr 3:165,123,087...165,156,453
Ensembl chr 3:165,123,095...165,149,397

G

ring-box 1

increases expression

ISO

Heme metabolite results in increased expression of RBX1 mRNA

NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191

G

RELA proto-oncogene, NF-kB subunit

affects localization
multiple interactions
increases localization

ISO

Heme analog affects the localization of RELA protein
LY96 protein promotes the reaction [Heme results in increased localization of RELA protein]

PMID:23355332 PMID:36115635

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RHEB like 1

increases expression

ISO

Heme metabolite results in increased expression of RHEBL1 mRNA

NCBI chr 7:131,905,207...131,910,088
Ensembl chr 7:131,905,207...131,909,199

G

RNA polymerase II associated protein 1

decreases expression

ISO

Heme metabolite results in decreased expression of RPAP1 mRNA

NCBI chr 3:127,200,450...127,221,985
Ensembl chr 3:127,110,550...127,221,952

G

ribosomal protein S6 kinase A2

increases expression

ISO

Heme metabolite results in increased expression of RPS6KA2 mRNA

NCBI chr 1:55,178,988...55,454,271
Ensembl chr 1:55,179,319...55,454,338

G

RT1 class Ia, locus A2

increases expression

ISO

Heme metabolite results in increased expression of H2-T23 mRNA

NCBI chr20:4,872,720...4,876,425

G

RT1 class II, locus Bb

decreases expression

ISO

Heme metabolite results in decreased expression of H2-AB1 mRNA

NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118

G

RT1 class I, locus CE16

decreases expression

ISO

Heme metabolite results in decreased expression of H2-Q1 mRNA

NCBI chr20:3,261,656...3,265,548

G

SET domain bifurcated histone lysine methyltransferase 1

decreases expression

ISO

Heme metabolite results in decreased expression of SETDB1 mRNA

NCBI chr 2:185,587,722...185,619,084
Ensembl chr 2:185,587,722...185,618,982

G

SLAM family member 7

increases expression

ISO

Heme metabolite results in increased expression of SLAMF7 mRNA

NCBI chr13:86,668,060...86,688,222
Ensembl chr13:86,668,060...86,686,341

G

solute carrier family 46 member 1

multiple interactions
increases uptake

ISO

SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme

NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,859,504...63,866,869

G

SWI/SNF related BAF chromatin remodeling complex subunit B1

decreases expression

ISO

Heme metabolite results in decreased expression of SMARCB1 mRNA

NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,740,943...12,763,055

G

structural maintenance of chromosomes 4

decreases expression

ISO

Heme metabolite results in decreased expression of SMC4 mRNA

NCBI chr 2:155,550,262...155,578,695
Ensembl chr 2:155,550,262...155,581,937

G

signal recognition particle 9

increases expression

ISO

Heme metabolite results in increased expression of SRP9 mRNA

NCBI chr13:96,364,253...96,372,393
Ensembl chr13:96,364,298...96,373,257

G

StAR-related lipid transfer domain containing 4

increases expression

ISO

Heme metabolite results in increased expression of STARD4 mRNA

NCBI chr18:25,088,831...25,104,172
Ensembl chr18:25,091,255...25,104,172

G

TATA-box binding protein associated factor 7

increases expression

ISO

Heme metabolite results in increased expression of TAF7 mRNA

NCBI chr18:29,704,182...29,713,382
Ensembl chr18:29,705,920...29,712,712

G

tryptophan 2,3-dioxygenase

multiple interactions

EXP

Heme promotes the reaction [pyridine results in increased activity of TDO2 protein]

NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586

G

toll-like receptor 4

affects binding
multiple interactions

ISO

Heme binds to TLR4 protein
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to LY96 protein]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to MYD88 protein]]; Heme promotes the reaction [TLR4 protein binds to LY96 protein]; Heme promotes the reaction [TLR4 protein binds to MYD88 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions
increases expression
increases secretion

ISO

Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
LY96 protein promotes the reaction [Heme results in increased expression of TNF mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of TNF protein]
Heme results in increased expression of TNF mRNA; Heme results in increased expression of TNF protein
Heme analog results in increased secretion of TNF protein

PMID:11076874 PMID:23355332 PMID:36115635

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF superfamily member 13b

decreases expression

ISO

Heme metabolite results in decreased expression of TNFSF13B mRNA

NCBI chr16:86,164,377...86,195,072
Ensembl chr16:86,164,377...86,194,499

G

toll interacting protein

increases expression

ISO

Heme metabolite results in increased expression of TOLLIP mRNA

NCBI chr 1:206,391,120...206,413,809
Ensembl chr 1:206,380,308...206,411,988

G

tubulin, alpha 4A

increases expression

ISO

Heme metabolite results in increased expression of TUBA4A mRNA

NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:84,158,280...84,162,584

G

ubiquitin-conjugating enzyme E2L 3

increases expression

ISO

Heme metabolite results in increased expression of UBE2L3 mRNA

NCBI chr11:97,300,584...97,343,084
Ensembl chr11:97,301,945...97,343,084

G

ubiquitin-conjugating enzyme E2R 2

decreases expression

ISO

Heme metabolite results in decreased expression of UBE2R2 mRNA

NCBI chr 5:61,082,552...61,141,099
Ensembl chr 5:61,082,552...61,141,452

G

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2

decreases expression

ISO

Heme metabolite results in decreased expression of WFIKKN2 mRNA

NCBI chr10:79,682,459...79,688,553
Ensembl chr10:79,682,459...79,688,553

G

YEATS domain containing 2

decreases expression

ISO

Heme metabolite results in decreased expression of YEATS2 mRNA

NCBI chr11:94,247,538...94,333,652
Ensembl chr11:94,247,538...94,333,292

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aconitase 1

decreases activity

EXP

Hemin results in decreased activity of ACO1 protein

NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:60,055,866...60,112,600

G

aconitase 2

increases expression

EXP

Hemin results in increased expression of ACO2 protein

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

adiponectin, C1Q and collagen domain containing

increases secretion

EXP

Hemin results in increased secretion of ADIPOQ protein

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

AKT serine/threonine kinase 1

multiple interactions

ISO

Hemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

5'-aminolevulinate synthase 1

increases degradation

EXP

Hemin results in increased degradation of ALAS1 protein

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

5'-aminolevulinate synthase 2

increases expression
multiple interactions

ISO

Hemin results in increased expression of ALAS2 mRNA
[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol promotes the reaction [Hemin results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of ALAS2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of ALAS2 mRNA]

PMID:23973255 PMID:24141029 PMID:28552822

NCBI chr X:22,890,650...22,914,046
Ensembl chr X:22,890,689...22,914,043

G

albumin

affects binding

ISO

Hemin binds to ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 2 family member

multiple interactions

EXP

Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

alkaline phosphatase, biomineralization associated

decreases expression

EXP

Hemin results in decreased expression of ALPL mRNA

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

ARF like GTPase 6 interacting protein 5

increases expression

ISO

Hemin results in increased expression of ARL6IP5 protein

NCBI chr 4:131,365,320...131,395,311
Ensembl chr 4:131,367,289...131,400,130

G

BTB domain and CNC homolog 1

multiple interactions
affects localization
increases expression

ISO

[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] affects the localization of BACH1 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of BACH1 protein; [Hemin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of BACH1 mRNA; BACH1 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]; Hemin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BACH1 protein]; Hemin results in decreased localization of and results in decreased activity of BACH1 protein
Hemin affects the localization of BACH1 protein
Hemin results in increased expression of BACH1 mRNA; Hemin results in increased expression of BACH1 protein

PMID:18550526 PMID:31518892 PMID:33434570 PMID:36096218

NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO
EXP

Hemin promotes the reaction [Cisplatin results in increased expression of BAX protein]
Hemin results in increased expression of BAX protein
Hemin inhibits the reaction [lead acetate results in increased expression of BAX protein]

PMID:27815112 PMID:29797346

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

ISO
EXP

Hemin results in decreased expression of BCL2 protein
Hemin inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]

PMID:27815112 PMID:29797346

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

bone gamma-carboxyglutamate protein

decreases expression
multiple interactions

EXP

Hemin results in decreased expression of BGLAP mRNA
15-deoxyprostaglandin J2 inhibits the reaction [Hemin results in decreased expression of BGLAP mRNA]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased expression of BGLAP mRNA]

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

baculoviral IAP repeat-containing 2

increases expression

ISO

Hemin results in increased expression of BIRC2 protein

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

caspase 3

multiple interactions
increases cleavage

EXP
ISO

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in increased cleavage of CASP3 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
Hemin promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Hemin results in increased expression of and results in increased cleavage of CASP3 protein
Hemin results in increased cleavage of CASP3 protein
[SESN2 protein affects the susceptibility to Hemin] which results in decreased expression of CASP3 protein modified form

PMID:17173083 PMID:18845130 PMID:19150641 PMID:19520142 PMID:26747958 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

increases expression

ISO

Hemin results in increased expression of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

EXP
ISO

Hemin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]
Hemin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of CAT protein]; Hemin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]

PMID:19150641 PMID:27815112 PMID:35691465

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

Hemin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cadherin 1

multiple interactions

EXP

[Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of CDH1 mRNA

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

ISO

Hemin results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Hemin results in increased expression of CDKN1A protein]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

decreases degradation

ISO

Hemin results in decreased degradation of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

CCAAT/enhancer binding protein alpha

multiple interactions
increases expression

ISO

HAMP mRNA promotes the reaction [Hemin results in increased expression of CEBPA mRNA]

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

chromodomain helicase DNA binding protein 4

multiple interactions

ISO

[Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]; [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; [Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein

NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:159,584,654...159,617,866

G

catechol-O-methyltransferase

multiple interactions

ISO

COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

corticotropin releasing hormone

increases secretion
multiple interactions

ISO

Hemin results in increased secretion of CRH protein
mesoporphyrin IX analog inhibits the reaction [Hemin results in increased secretion of CRH protein]

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

cytochrome b-245 beta chain

multiple interactions

EXP

Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]; Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]]

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

ISO
EXP

Hemin inhibits the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [Mercuric Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [sodium arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]

PMID:20188822 PMID:20837117 PMID:22120038 PMID:22159698 PMID:26747958

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

EXP

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP1A2 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A2 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A2 protein]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]]

PMID:22159698 PMID:26747958

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

EXP

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP2B1 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP2B1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP2B1 protein]

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

ISO

Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP
ISO

Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]
Hemin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]

PMID:19325051 PMID:26747958

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

EXP
ISO

Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of DDIT3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of DDIT3 protein]
Hemin results in increased expression of DDIT3 mRNA

PMID:26747958 PMID:29749404

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

discs large MAGUK scaffold protein 1

multiple interactions

ISO

Hemin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of DLG1 protein]

NCBI chr11:82,416,853...82,607,797
Ensembl chr11:82,416,853...82,607,797

G

ephrin A1

multiple interactions

ISO

[hydroquinone co-treated with Hemin] affects the expression of EFNA1 mRNA

NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

EXP

Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Hemin results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Hemin results in increased expression of FOS mRNA]; KN 62 inhibits the reaction [Hemin results in increased expression of FOS mRNA]; staurosporine aglycone inhibits the reaction [Hemin results in increased expression of FOS mRNA]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FOS like 1, AP-1 transcription factor subunit

decreases expression

ISO

Hemin results in decreased expression of FOSL1 protein

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

ferritin heavy chain 1

increases expression

EXP
ISO

Hemin results in increased expression of FTH1 mRNA; Hemin results in increased expression of FTH1 protein

PMID:15893546 PMID:16568477 PMID:17469137 PMID:29749404 PMID:31054940

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

ferritin light chain 1

multiple interactions
increases expression

ISO
EXP

[Hemin results in increased abundance of Iron] which results in increased expression of FTL mRNA
Hemin results in increased expression of FTL mRNA; Hemin results in increased expression of FTL1 protein
Hemin results in increased expression of FTL1 mRNA

PMID:12393473 PMID:15893546 PMID:16568477 PMID:29749404

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

growth arrest-specific 1

multiple interactions

ISO

[Hemin results in increased abundance of Iron] which results in increased expression of GAS1 mRNA

NCBI chr17:4,487,716...4,490,701
Ensembl chr17:4,484,283...4,497,657

G

GATA binding protein 1

increases expression
multiple interactions
affects expression
decreases expression

ISO

Hemin results in increased expression of GATA1 mRNA
catechol promotes the reaction [Hemin results in increased expression of GATA1 mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; Hemin promotes the reaction [catechol results in increased expression of GATA1 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]
Hemin affects the expression of GATA1 mRNA
Hemin results in decreased expression of GATA1 protein

PMID:21414390 PMID:23973255 PMID:28552822 PMID:37329354

NCBI chr X:17,193,291...17,209,462
Ensembl chr X:17,201,633...17,209,459

G

GATA binding protein 2

decreases expression
multiple interactions
affects expression

ISO

Hemin results in decreased expression of GATA2 mRNA; Hemin results in decreased expression of GATA2 protein
hydroquinone affects the reaction [Hemin affects the expression of GATA2 mRNA]; hydroquinone inhibits the reaction [Hemin results in decreased expression of GATA2 protein]; hydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]; hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]; Phenol promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]

PMID:21414390 PMID:37329354

NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

ISO

Hemin results in increased expression of GCLC mRNA; Hemin results in increased expression of GCLC protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC protein

PMID:16631525 PMID:33434570

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

increases expression
multiple interactions

ISO

Hemin results in increased expression of GCLM mRNA; Hemin results in increased expression of GCLM protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLM mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLM protein

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glutamic--pyruvic transaminase

multiple interactions
increases export

ISO

HSPA8 protein inhibits the reaction [Hemin results in increased export of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione-disulfide reductase

multiple interactions
increases expression

ISO

[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSR mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSR protein
Hemin results in increased expression of GSR mRNA; Hemin results in increased expression of GSR protein

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 4

increases expression

ISO

Hemin results in increased expression of GSTA4 mRNA

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488

G

glutathione S-transferase omega 1

increases expression
multiple interactions

ISO

Hemin results in increased expression of GSTO1 mRNA
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSTO1 mRNA

NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:256,662,531...256,676,167

G

glutathione S-transferase pi 1

multiple interactions

ISO

Hemin results in increased stability of and results in increased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glutathione S-transferase zeta 1

decreases activity

ISO

Hemin results in decreased activity of GSTZ1 protein

NCBI chr 6:112,525,576...112,536,228
Ensembl chr 6:112,525,377...112,536,233

G

hepcidin antimicrobial peptide

increases expression
decreases response to substance
multiple interactions

ISO

Hemin results in increased expression of HAMP mRNA
HAMP mRNA results in decreased susceptibility to Hemin
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of HIF1A mRNA; [HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of IL6 mRNA; HAMP mRNA promotes the reaction [Hemin results in increased expression of CEBPA mRNA]; necrostatin-1 promotes the reaction [HAMP mRNA results in decreased susceptibility to Hemin]

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

hemoglobin subunit beta

multiple interactions
increases expression

ISO

[catechol co-treated with Hemin] results in increased expression of HBB mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol promotes the reaction [Hemin results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Decitabine inhibits the reaction [hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Hemin promotes the reaction [catechol results in increased expression of HBB mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]; trichostatin A inhibits the reaction [hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]

PMID:21414390 PMID:23973255 PMID:24141029 PMID:28552822 PMID:30327826

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases expression

ISO

[Hemin results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA
Hemin results in decreased expression of HIF1A mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of HIF1A mRNA

PMID:12393473 PMID:29749404

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

hydroxymethylbilane synthase

multiple interactions
increases expression

ISO

[catechol co-treated with Hemin] results in increased expression of HMBS mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol promotes the reaction [Hemin results in increased expression of HMBS mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]; Hemin promotes the reaction [catechol results in increased expression of HMBS mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA]

PMID:21414390 PMID:23973255 PMID:24141029 PMID:28552822

NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:53,570,364...53,577,802

G

heme oxygenase 1

multiple interactions
decreases response to substance
increases activity
increases expression
decreases expression

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of HMOX1 mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of HMOX1 protein; [Hemin results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA; [Hemin results in increased activity of HMOX1 protein] which results in decreased chemical synthesis of Reactive Oxygen Species; [Hemin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; BACH1 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in increased expression of HMOX1 mRNA]; diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Genistein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Hemin results in increased expression of and results in increased activity of HMOX1 protein; herbimycin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; HMOX1 protein promotes the reaction [Hemin results in decreased susceptibility to IL18 protein]; IFNG protein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]
HMOX1 protein results in decreased susceptibility to Hemin
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin co-treated with Hemin] results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Hemin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; Hemin promotes the reaction [3-hydroxyflavone results in increased expression of HMOX1 protein]; Hemin promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 protein]; Hemin promotes the reaction [baicalein results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [kaempferol results in increased expression of HMOX1 protein]; Hemin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Quercetin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in decreased expression of HMOX1 protein; [Hemin co-treated with Fructose] results in increased expression of HMOX1 protein; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 mRNA; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 protein; [Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of HMOX1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in decreased expression of HMOX1 protein]; chromium mesoporphyrin inhibits the reaction [[Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein]; Hemin inhibits the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; Hemin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Paraquat results in increased expression of HMOX1 mRNA]; protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [Hemin results in decreased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
Hemin results in increased expression of HMOX1 mRNA; Hemin results in increased expression of HMOX1 protein

PMID:3343248 PMID:8764571 PMID:9337616 PMID:9722676 PMID:10349844 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heme oxygenase 2

decreases response to substance

ISO

HMOX2 protein results in decreased susceptibility to Hemin

PMID:15589375 PMID:16459095

NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800

G

heat shock transcription factor 1

increases activity

ISO

Hemin results in increased activity of HSF1 protein

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

ISO

[Hemin results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA

NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877

G

heat shock protein family A (Hsp70) member 8

multiple interactions

ISO

HSPA8 protein inhibits the reaction [Hemin results in increased export of GPT protein]

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

heat shock protein family A (Hsp70) member 9

multiple interactions

ISO

[Hemin results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398

G

heat shock protein family H (Hsp110) member 1

multiple interactions

ISO

[Hemin results in increased abundance of Iron] which results in increased expression of HSPH1 mRNA

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891

G

interferon gamma

multiple interactions

ISO

IFNG protein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 18

multiple interactions
decreases response to substance

ISO

Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein]; Hemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Hemin inhibits the reaction [IL18 protein results in increased expression of MAPK14 protein]; Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]; HMOX1 protein promotes the reaction [Hemin results in decreased susceptibility to IL18 protein]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 beta

multiple interactions

ISO

Hemin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

increases expression
multiple interactions

ISO

Hemin results in increased expression of IL6 mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of IL6 mRNA; Hemin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein]

PMID:29749404 PMID:35691465

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 2

multiple interactions

EXP

Hemin inhibits the reaction [Fructose results in increased expression of INS protein]

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

iron responsive element binding protein 2

multiple interactions

EXP

Hemin results in decreased expression of and results in decreased activity of IREB2 protein

NCBI chr 8:64,124,152...64,207,702
Ensembl chr 8:64,154,945...64,205,520

G

involucrin

decreases expression

ISO

Hemin results in decreased expression of IVL mRNA

NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

ISO
EXP

[Hemin results in decreased abundance of Iron] which results in increased expression of JUN mRNA
Hemin promotes the reaction [Paraquat results in increased phosphorylation of JUN protein]
Hemin results in decreased expression of JUN mRNA

PMID:12393473 PMID:19080378 PMID:20016031

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

Kelch-like ECH-associated protein 1

decreases expression

ISO

Hemin results in decreased expression of KEAP1 protein

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

lysyl oxidase

multiple interactions

ISO

[Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810

G

membrane associated guanylate kinase, WW and PDZ domain containing 1

multiple interactions

ISO

[Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 protein; [hydroquinone co-treated with Hemin] affects the expression of MAGI1 mRNA; [hydroquinone co-treated with Hemin] affects the expression of MAGI1 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein]

NCBI chr 4:127,762,590...128,368,228
Ensembl chr 4:127,762,590...128,367,833

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

ISO

Hemin results in increased phosphorylation of MAPK1 protein
diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen-activated protein kinase 11

multiple interactions

ISO

Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein]

NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038

G

mitogen activated protein kinase 14

multiple interactions

ISO

Hemin inhibits the reaction [IL18 protein results in increased expression of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

EXP

Hemin promotes the reaction [Paraquat results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions
decreases expression

EXP

chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]
Hemin results in decreased expression of MAPK9 mRNA

PMID:19190261 PMID:20016031

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

mitofusin 1

multiple interactions

EXP

Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]; Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

microsomal glutathione S-transferase 1

multiple interactions

EXP

Hemin inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

microRNA 126a

decreases expression

ISO

Hemin results in decreased expression of MIR126 mRNA

NCBI chr 3:29,813,150...29,813,267

G

microRNA 451a

increases expression
multiple interactions

ISO

Hemin results in increased expression of MIR451A mRNA
hydroquinone affects the reaction [Hemin results in increased expression of MIR451A mRNA]

NCBI chr10:63,459,569...63,459,640
Ensembl chr10:63,459,569...63,459,640

G

microRNA 486

increases expression
multiple interactions

ISO

Hemin results in increased expression of MIR486-1 mRNA
[Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 protein; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 protein; hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of MIR486-1 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]

G

matrix metallopeptidase 1

increases expression

ISO

Hemin results in increased expression of MMP1 protein

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964

G

myeloperoxidase

multiple interactions

EXP

Hemin inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

metallothionein 2

multiple interactions

ISO

[Hemin results in decreased abundance of Iron] which results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

ISO

[Hemin results in increased abundance of Iron] which results in increased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

nuclear factor, erythroid 2

increases expression
multiple interactions

ISO

Hemin results in increased expression of NFE2 mRNA
catechol promotes the reaction [Hemin results in increased expression of NFE2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of NFE2 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]

PMID:21414390 PMID:28552822

NCBI chr 7:136,261,234...136,273,850
Ensembl chr 7:136,261,236...136,268,585

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression
increases expression
affects localization

ISO
EXP

[Antineoplastic Agents binds to and results in decreased activity of NFE2L2 protein] inhibits the reaction [Hemin results in increased expression of SESN2 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of and affects the localization of NFE2L2 protein; diacetyldichlorofluorescein inhibits the reaction [Hemin affects the localization of NFE2L2 protein]; Hemin promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; Hemin results in increased expression of and affects the localization of NFE2L2 protein; SESN2 protein inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]
NFE2L2 gene mutant form inhibits the reaction [Hemin results in increased expression of CYP2A5 mRNA]; NFE2L2 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]
Hemin results in decreased expression of NFE2L2 protein
[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Hemin] affects the localization of NFE2L2 protein; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in decreased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]

PMID:10473555 PMID:16959797 PMID:21464371 PMID:21525764 PMID:22859313 More...

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nitric oxide synthase 2

multiple interactions

ISO
EXP

Hemin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]; Hemin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Hemin promotes the reaction [3-hydroxyflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; Hemin promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; Hemin promotes the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 protein]

PMID:14563492 PMID:15316927 PMID:26747958 PMID:27815112

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

multiple interactions

EXP

[Nitroglycerin co-treated with Hemin] results in increased expression of NOS3 mRNA

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

ISO

Hemin results in increased expression of NQO1 mRNA; Hemin results in increased expression of NQO1 protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of NQO1 mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of NQO1 protein; Hemin promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NQO1 protein]

PMID:21464371 PMID:31054940 PMID:33434570

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear respiratory factor 1

multiple interactions

EXP

Hemin inhibits the reaction [manganese chloride affects the expression of NRF1 protein]

NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353

G

O-linked N-acetylglucosamine (GlcNAc) transferase

multiple interactions

ISO

[Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]

NCBI chr X:70,811,317...70,856,123
Ensembl chr X:70,811,319...70,856,123

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

Hemin results in increased expression of and results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

phosphodiesterase 5A

decreases expression

EXP

Hemin results in decreased expression of PDE5A protein

NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298

G

platelet derived growth factor subunit B

multiple interactions

ISO

[Hemin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343

G

platelet derived growth factor receptor beta

multiple interactions

ISO

[hydroquinone co-treated with Hemin] affects the expression of PDGFRB mRNA

NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233

G

peripheral myelin protein 22

multiple interactions

ISO

[Hemin results in decreased abundance of Iron] which results in increased expression of PMP22 mRNA

NCBI chr10:48,294,932...48,324,941
Ensembl chr10:48,297,437...48,324,940

G

cytochrome p450 oxidoreductase

multiple interactions
decreases activity

ISO

Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Dimethyl Sulfoxide promotes the reaction [Hemin results in decreased activity of POR protein]; Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin promotes the reaction [Dimethyl Sulfoxide results in decreased activity of POR protein]

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

PPARG coactivator 1 alpha

multiple interactions

EXP

Hemin inhibits the reaction [manganese chloride affects the expression of PPARGC1A protein]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

phosphatase and tensin homolog

multiple interactions

ISO

Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin E receptor 2

increases response to substance

ISO

PTGER2 gene mutant form results in increased susceptibility to Hemin

NCBI chr15:20,694,765...20,708,475
Ensembl chr15:20,696,013...20,708,950

G

RAP1A, member of RAS oncogene family

multiple interactions

ISO

[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAP1A protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]

NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808

G

Rap guanine nucleotide exchange factor 2

multiple interactions

ISO

[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]

NCBI chr 2:166,505,868...166,728,139
Ensembl chr 2:166,505,868...166,726,698

G

Ras association domain family member 5

multiple interactions

ISO

[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 protein; [hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein; hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein]

NCBI chr13:45,189,768...45,255,277
Ensembl chr13:45,189,804...45,255,277

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression

EXP

chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
Hemin results in decreased expression of RELA mRNA

PMID:19190261 PMID:20016031

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RUNX family transcription factor 2

decreases expression

EXP

Hemin results in decreased expression of RUNX2 mRNA

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

sestrin 2

multiple interactions
affects response to substance
increases expression

ISO

[SESN2 protein affects the susceptibility to Hemin] which results in decreased expression of CASP3 protein modified form
Hemin results in increased expression of SESN2 protein
[Antineoplastic Agents binds to and results in decreased activity of NFE2L2 protein] inhibits the reaction [Hemin results in increased expression of SESN2 protein]; Acetylcysteine inhibits the reaction [Hemin results in increased expression of SESN2 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NQO1 protein]

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

solute carrier family 2 member 4

multiple interactions

EXP

chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Hemin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

superoxide dismutase 2

multiple interactions

EXP

Hemin promotes the reaction [Acetaminophen results in increased expression of SOD2 protein]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

synapsin I

multiple interactions

ISO

Hemin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SYN1 protein]

NCBI chr X:3,725,745...3,780,940
Ensembl chr X:3,725,714...3,780,938

G

transcription factor AP-2 gamma

decreases expression

EXP

Hemin results in decreased expression of TFAP2C mRNA

NCBI chr 3:181,733,524...181,742,412
Ensembl chr 3:181,733,419...181,741,404

G

transferrin receptor

decreases expression
multiple interactions

EXP
ISO

Hemin results in decreased expression of TFRC protein
[Hemin results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; hydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; Phenol promotes the reaction [Hemin results in decreased expression of TFRC mRNA]
Hemin results in decreased expression of TFRC mRNA; Hemin results in decreased expression of TFRC protein

PMID:12393473 PMID:16568477 PMID:16760464 PMID:21414390 PMID:25576684

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

transglutaminase 2

multiple interactions

ISO

[Hemin co-treated with Tretinoin] affects the localization of TGM2 protein

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240

G

tumor necrosis factor

multiple interactions

EXP
ISO

[Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of TNF mRNA; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased expression of TNF]; Hemin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
Hemin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]; Hemin inhibits the reaction [Cisplatin results in increased expression of TNF protein]

PMID:17173083 PMID:19150641 PMID:26747958 PMID:27815112 PMID:29269057 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 10b

increases expression

ISO

Hemin results in increased expression of TNFRSF10A protein

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082

G

TNF receptor superfamily member 1A

increases expression

ISO

Hemin results in increased expression of TNFRSF1A protein

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 1B

increases expression

ISO

Hemin results in increased expression of TNFRSF1B protein

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411

G

TNF receptor superfamily member 25

increases expression

ISO

Hemin results in increased expression of TNFRSF25 protein

NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:167,904,786...167,909,052

G

unc-51 like autophagy activating kinase 1

increases expression

ISO

Hemin results in increased expression of ATG1 protein

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746

G

vasodilator-stimulated phosphoprotein

multiple interactions

EXP

Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein]

NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650

G

X-box binding protein 1

increases splicing

ISO

Hemin results in increased splicing of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

zinc finger protein 36

multiple interactions
increases expression

ISO

zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of ZFP36 mRNA]

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108

zinc protoporphyrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]
zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]

PMID:20052772 PMID:20861358

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

angiotensinogen

multiple interactions

ISO

[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

AKT serine/threonine kinase 1

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aminolevulinate dehydratase

affects abundance

ISO

ALAD gene SNP affects the abundance of zinc protoporphyrin

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

albumin

multiple interactions

ISO

ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein]
zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [ALB protein results in increased expression of TIMP1 protein]

PMID:19376148 PMID:21163135

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

ALMS1, centrosome and basal body associated protein

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ALMS1 mRNA

NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:119,683,076...119,783,471

G

adaptor related protein complex 2 subunit alpha 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of AP2A1 mRNA

NCBI chr 1:104,520,789...104,550,655
Ensembl chr 1:104,520,792...104,550,655

G

adaptor related protein complex 3 subunit delta 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of AP3D1 mRNA

NCBI chr 7:9,620,909...9,656,350
Ensembl chr 7:9,620,968...9,656,342

G

anti-silencing function 1A histone chaperone

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ASF1A mRNA

NCBI chr20:33,436,632...33,451,478
Ensembl chr20:33,436,707...33,449,639

G

BTB domain and CNC homolog 1

multiple interactions

EXP

zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in decreased expression of NFE2L2 mRNA]]; zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in increased expression of PTGS2 mRNA]]; zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in increased expression of PTGS2 protein]]

NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]

PMID:22763982 PMID:27523796 PMID:27815112 PMID:32621855

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]

PMID:22763982 PMID:27523796 PMID:32621855

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions
increases expression

EXP
ISO

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of BCL2L1 protein]
zinc protoporphyrin results in increased expression of BCL2L1 protein

PMID:20357190 PMID:27829220

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

increases expression

ISO

zinc protoporphyrin results in increased expression of BCL2L11 protein

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

bone gamma-carboxyglutamate protein

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [15-deoxyprostaglandin J2 results in decreased expression of BGLAP mRNA]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased expression of BGLAP mRNA]

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

baculoviral IAP repeat-containing 3

multiple interactions

ISO

zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of BIRC3 protein]

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

calcitonin-related polypeptide alpha

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [monophosphoryl lipid A results in increased expression of CALCA mRNA]

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529

G

cullin-associated and neddylation-dissociated 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CAND1 mRNA

NCBI chr 7:56,566,765...56,604,653
Ensembl chr 7:56,551,394...56,604,655

G

caspase 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 3

multiple interactions
increases cleavage
decreases activity

ISO
EXP

zinc protoporphyrin inhibits the reaction [[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP3 protein]
zinc protoporphyrin results in increased cleavage of CASP3 protein
zinc protoporphyrin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP3 protein]
zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]]; zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]
zinc protoporphyrin results in decreased activity of CASP3 protein

PMID:16051694 PMID:17928392 PMID:20357190 PMID:21295052 PMID:22763982 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]; zinc protoporphyrin promotes the reaction [quinocetone results in increased activity of CASP9 protein]
zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]]; zinc protoporphyrin promotes the reaction [T-2 Toxin results in increased activity of CASP9 protein]

PMID:27375190 PMID:29432840 PMID:30261164

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

EXP
ISO

zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]]
zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of CAT protein]]

PMID:32621855 PMID:35691465

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

coiled-coil domain containing 6

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of CCDC6 mRNA

NCBI chr20:18,431,243...18,527,227
Ensembl chr20:18,431,243...18,527,227

G

C-C motif chemokine ligand 2

multiple interactions

EXP
ISO

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of CCL2 protein]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of CCL2 mRNA]
zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CCL2 protein]]

PMID:20357190 PMID:23892052 PMID:35691465

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine receptor 7

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CCR7 mRNA]

NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501

G

CD40 molecule

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

Cd80 molecule

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA]

NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540

G

CD83 molecule

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD83 mRNA]

NCBI chr17:21,093,281...21,113,223
Ensembl chr17:21,093,281...21,113,047

G

CD86 molecule

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA]

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361

G

cyclin-dependent kinase 13

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CDK13 mRNA

NCBI chr17:51,945,975...52,040,218
Ensembl chr17:51,946,701...52,037,257

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of CDKN1A protein]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

chromodomain helicase DNA binding protein 7

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CHD7 mRNA

NCBI chr 5:26,609,245...26,792,736
Ensembl chr 5:26,609,407...26,792,734

G

carboxymethylenebutenolidase homolog

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CMBL mRNA

NCBI chr 2:84,280,128...84,301,878
Ensembl chr 2:84,242,512...84,301,880

G

C-X-C motif chemokine ligand 1

increases expression

EXP

zinc protoporphyrin results in increased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 2

increases expression

EXP

zinc protoporphyrin results in increased expression of CXCL2 mRNA

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

EXP

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

EXP

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

EXP

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2B1 protein

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP
ISO

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of CYP2E1 protein; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]
zinc protoporphyrin inhibits the reaction [Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein]]

PMID:19325051 PMID:26747958

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

defective in cullin neddylation 1 domain containing 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of DCUN1D1 mRNA

NCBI chr 2:120,649,445...120,700,879
Ensembl chr 2:120,649,445...120,700,870

G

DNA-damage inducible transcript 3

multiple interactions

EXP

zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of DDIT3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DExH-box helicase 29

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of DHX29 mRNA

NCBI chr 2:46,293,901...46,344,652
Ensembl chr 2:46,293,677...46,344,948

G

dual specificity phosphatase 10

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 mRNA]; zinc protoporphyrin inhibits the reaction [andrographolide results in increased expression of DUSP10 protein]

NCBI chr13:98,145,317...98,183,304
Ensembl chr13:98,145,893...98,183,304

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

EXP

zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

EMAP like 4

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of EML4 mRNA

NCBI chr 6:16,972,054...17,087,365
Ensembl chr 6:16,972,075...17,087,439

G

coagulation factor II, thrombin

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 protein]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]]

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246

G

Fas ligand

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased activity of CASP8 protein]; zinc protoporphyrin inhibits the reaction [FASLG protein results in increased cleavage of CASP3 protein]

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

F-box and WD repeat domain containing 12

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FBXW12 mRNA

NCBI chr 8:118,660,777...118,680,565
Ensembl chr 8:118,660,605...118,680,572

G

Fibroblast growth factor receptor 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FGFR1 mRNA

NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855

G

Fms related receptor tyrosine kinase 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

zinc protoporphyrin results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

fucosyltransferase 4

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of FUT4 mRNA

NCBI chr 8:19,868,178...19,872,139
Ensembl chr 8:19,868,079...19,872,436

G

glutamate-ammonia ligase

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Ammonia results in decreased activity of GLUL protein]]; zinc protoporphyrin inhibits the reaction [Resveratrol results in increased activity of GLUL protein]

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

G protein-coupled receptor 132

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of GPR132 mRNA

NCBI chr 6:137,745,142...137,763,037
Ensembl chr 6:137,745,241...137,763,157

G

glutathione peroxidase 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 4

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of GPX4 protein]
zinc protoporphyrin inhibits the reaction [Cadmium results in decreased expression of GPX4 protein]

PMID:36696656 PMID:39025289

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

gasdermin D

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]]

NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]

NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:169,716,709...169,779,737

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]

NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:169,646,898...169,696,987

G

HAUS augmin like complex subunit 2

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of HAUS2 mRNA

NCBI chr 3:128,006,894...128,019,730
Ensembl chr 3:128,006,932...128,019,729

G

hepatitis A virus cellular receptor 1

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [Cadmium results in increased expression of HAVCR1 protein]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

homeostatic iron regulator

affects abundance

ISO

HFE gene polymorphism affects the abundance of zinc protoporphyrin

NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,841,252...41,851,208

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [HIF1A protein results in increased activity of SOD2 protein]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

high mobility group box 1

multiple interactions

EXP
ISO

zinc protoporphyrin promotes the reaction [lead acetate results in increased expression of HMGB1 mRNA]
zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]

PMID:29447957 PMID:30261164

NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327

G

heme oxygenase 1

multiple interactions
decreases expression
increases expression
affects expression
decreases activity

ISO
EXP

[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TP53 protein]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to 2-butenal; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in increased susceptibility to Arsenic Trioxide; [zinc protoporphyrin results in decreased activity of HMOX1] which results in decreased susceptibility to peoniflorin; zinc protoporphyrin analog inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in increased abundance of Malondialdehyde]]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to Ethanol]; zinc protoporphyrin inhibits the reaction [ALB protein results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Cilostazol results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Cilostazol results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased activity of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; zinc protoporphyrin results in decreased expression of and results in decreased activity of HMOX1 protein; zinc protoporphyrin results in increased expression of and results in decreased activity of HMOX1 protein
zinc protoporphyrin results in decreased expression of HMOX1 mRNA; zinc protoporphyrin results in decreased expression of HMOX1 protein
zinc protoporphyrin results in increased expression of HMOX1 protein
zinc protoporphyrin affects the expression of HMOX1 mRNA; zinc protoporphyrin affects the expression of HMOX1 protein
zinc protoporphyrin results in decreased activity of HMOX1; zinc protoporphyrin results in decreased activity of HMOX1 protein
zinc protoporphyrin results in increased expression of HMOX1 mRNA; zinc protoporphyrin results in increased expression of HMOX1 protein
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with zinc protoporphyrin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [Resveratrol results in increased abundance of Glutathione]; [zinc protoporphyrin results in decreased activity of HMOX1 protein] which results in decreased susceptibility to Resveratrol; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [olprinone results in increased activity of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [perflexane promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased activity of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Propofol promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of HMOX1 protein]
[zinc protoporphyrin co-treated with Hemin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; ALB protein inhibits the reaction [zinc protoporphyrin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [[Lipopolysaccharides co-treated with 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone] results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of HMOX1 protein]]

PMID:7524564 PMID:12352873 PMID:14649057 PMID:15602829 PMID:16462769 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heme oxygenase 2

decreases activity
decreases expression

ISO
EXP

zinc protoporphyrin results in decreased activity of HMOX2 protein
zinc protoporphyrin results in decreased expression of HMOX2 protein

PMID:21448202 PMID:25824035

NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800

G

heterochromatin protein 1, binding protein 3

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of HP1BP3 mRNA

NCBI chr 5:155,719,109...155,746,329
Ensembl chr 5:155,719,115...155,746,325

G

hydroxysteroid 11-beta dehydrogenase 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of HSD11B1 mRNA]]

NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432

G

intercellular adhesion molecule 1

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of ICAM1 mRNA]
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]

PMID:19608869 PMID:23892052 PMID:33049506

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon beta 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]

NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487

G

interferon gamma

multiple interactions
increases expression

EXP

zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]
zinc protoporphyrin results in increased expression of IFNG mRNA

PMID:21295052 PMID:25780291

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of IL10 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of IL10 protein]; zinc protoporphyrin inhibits the reaction [perflexane inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of IL10 protein]]

PMID:20056245 PMID:20360627

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 12B

multiple interactions

ISO

zinc protoporphyrin promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]]

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 18

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein]

PMID:18215737 PMID:36858639

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 beta

multiple interactions
increases expression

ISO
EXP

zinc protoporphyrin inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]]
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]
zinc protoporphyrin results in increased expression of IL1B mRNA
zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of HMOX1 protein]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of IL1B mRNA]

PMID:20131233 PMID:21295052 PMID:23892052 PMID:25780291 PMID:27523796 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 23 subunit alpha

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]]

NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434

G

interleukin 6

multiple interactions
increases expression

ISO
EXP

zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]]
zinc protoporphyrin results in increased expression of IL6 mRNA
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; zinc protoporphyrin inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]

PMID:19608869 PMID:20131233 PMID:21963524 PMID:25780291 PMID:27523796 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inositol polyphosphate-5-phosphatase D

decreases expression

EXP

zinc protoporphyrin results in decreased expression of INPP5D protein

NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:95,735,530...95,840,589

G

interleukin-1 receptor-associated kinase 1

multiple interactions

EXP

zinc protoporphyrin promotes the reaction [IRAK1 protein binds to MYD88 protein]

NCBI chr X:156,919,927...156,929,825
Ensembl chr X:156,920,081...156,929,825

G

interleukin-1 receptor-associated kinase 3

decreases expression

EXP

zinc protoporphyrin results in decreased expression of IRAK3 protein

NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:57,539,557...57,598,706

G

integrin subunit alpha M

increases expression

ISO

zinc protoporphyrin results in increased expression of ITGAM protein

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO

zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased expression of JUN protein]
zinc protoporphyrin results in increased expression of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

potassium voltage-gated channel subfamily A regulatory beta subunit 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KCNAB1 mRNA

NCBI chr 2:151,446,975...151,913,636
Ensembl chr 2:151,446,947...151,913,636

G

potassium channel tetramerization domain containing 20

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KCTD20 mRNA

NCBI chr20:7,017,480...7,034,440
Ensembl chr20:7,017,502...7,034,441

G

kinase D-interacting substrate 220

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of KIDINS220 mRNA

NCBI chr 6:47,346,790...47,435,599
Ensembl chr 6:47,346,832...47,431,865

G

KIT ligand

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KITLG mRNA

NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:36,782,638...36,863,793

G

KRAS proto-oncogene, GTPase

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KRAS mRNA

NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320

G

La ribonucleoprotein 1B

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LARP1B mRNA

NCBI chr 2:125,860,935...125,897,189
Ensembl chr 2:125,863,997...125,897,189

G

lipocalin 2

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [Cadmium results in increased expression of LCN2 protein]

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

lactate dehydrogenase A

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]]

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

ligand of numb-protein X 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LNX1 mRNA

NCBI chr14:33,868,517...33,971,217
Ensembl chr14:33,868,571...33,971,217

G

LYR motif containing 7

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LYRM7 mRNA

NCBI chr10:39,465,019...39,483,973
Ensembl chr10:39,465,036...39,484,240

G

microtubule-actin crosslinking factor 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of MACF1 mRNA

NCBI chr 5:140,908,829...141,234,127
Ensembl chr 5:140,908,837...141,233,890

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO

[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]]
zinc protoporphyrin results in increased phosphorylation of MAPK1 protein
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; zinc protoporphyrin promotes the reaction [Peptidoglycan results in increased phosphorylation of MAPK1 protein]

PMID:19376148 PMID:20523338 PMID:27523796

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [neferine inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]]
zinc protoporphyrin results in increased phosphorylation of MAPK3 protein
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin promotes the reaction [Peptidoglycan results in increased phosphorylation of MAPK3 protein]

PMID:19376148 PMID:20523338 PMID:27523796

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

microtubule affinity regulating kinase 2

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of MARK2 mRNA

NCBI chr 1:213,890,213...213,955,417
Ensembl chr 1:213,890,213...213,955,149

G

mitofusin 1

multiple interactions

EXP

Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

MLLT3, super elongation complex subunit

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of MLLT3 mRNA

NCBI chr 5:107,305,008...107,561,352
Ensembl chr 5:107,284,766...107,561,352

G

matrix metallopeptidase 2

affects expression
multiple interactions

EXP
ISO

zinc protoporphyrin affects the expression of MMP2
zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP2 protein]

PMID:23704825 PMID:30076913

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

multiple interactions

ISO

zinc protoporphyrin promotes the reaction [arsenic trioxide results in increased expression of MMP9 protein]
zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 mRNA]; zinc protoporphyrin inhibits the reaction [fisetin results in decreased expression of MMP9 protein]

PMID:27829220 PMID:30076913

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions

EXP

zinc protoporphyrin inhibits the reaction [perflexane inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of MPO protein]]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased activity of MPO protein]; zinc protoporphyrin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:17292349 PMID:20360627 PMID:23892052

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

MYD88, innate immune signal transduction adaptor

multiple interactions

EXP

zinc protoporphyrin promotes the reaction [IRAK1 protein binds to MYD88 protein]; zinc protoporphyrin promotes the reaction [TLR2 protein binds to MYD88 protein]; zinc protoporphyrin promotes the reaction [TLR4 protein binds to MYD88 protein]; zinc protoporphyrin promotes the reaction [TRAF6 protein binds to MYD88 protein]

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

neutrophil cytosolic factor 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to NCF1 protein]]]

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects expression

EXP

zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in decreased expression of NFE2L2 mRNA]]; zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]
zinc protoporphyrin affects the expression of NFE2L2 mRNA; zinc protoporphyrin affects the expression of NFE2L2 protein

PMID:23704825 PMID:25824035 PMID:38573338

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of NFKBIA protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of NFKBIA protein]
zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]]

PMID:20131233 PMID:21925249

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 1

multiple interactions

EXP

[Sildenafil Citrate co-treated with zinc protoporphyrin] results in increased expression of NOS1 mRNA

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 2

multiple interactions

ISO
EXP

[zinc protoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of NOS2 mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of NOS2 protein; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 mRNA]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 protein]

PMID:19376148 PMID:20357190 PMID:21925249 PMID:26460608 PMID:26747958 More...

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

phosphodiesterase 4D interacting protein

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PDE4DIP mRNA

NCBI chr 2:187,982,002...188,178,937
Ensembl chr 2:187,981,878...188,178,869

G

placental growth factor

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PGF mRNA

NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747

G

RNA polymerase III subunit K

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of POLR3K mRNA

NCBI chr 3:189,360,349...189,364,546
Ensembl chr 3:189,360,171...189,366,697

G

peroxisome proliferator-activated receptor gamma

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [cilostazol results in increased activity of PPARG protein]; zinc protoporphyrin inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

peptidylprolyl isomerase like 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of PPIL1 mRNA

NCBI chr20:7,303,919...7,323,962
Ensembl chr20:7,303,922...7,318,781

G

peroxiredoxin 2

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006

G

proline rich 11

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PRR11 mRNA

NCBI chr10:72,396,127...72,440,643
Ensembl chr10:72,398,667...72,418,275

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased expression of PTGS2 protein]]; zinc protoporphyrin promotes the reaction [Arsenic Trioxide results in increased expression of PTGS2]
zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in increased expression of PTGS2 mRNA]]; zinc protoporphyrin affects the reaction [BACH1 protein affects the reaction [Doxorubicin results in increased expression of PTGS2 protein]]; zinc protoporphyrin inhibits the reaction [Cadmium results in increased expression of PTGS2 protein]
zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

PMID:23649692 PMID:24003391 PMID:26385185 PMID:30261164 PMID:38573338 More...

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, non-receptor type 12

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of PTPN12 mRNA

NCBI chr 4:14,913,071...14,985,084
Ensembl chr 4:14,913,218...14,985,284

G

protein tyrosine phosphatase, receptor type, O

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PTPRO mRNA

NCBI chr 4:171,895,104...172,105,911
Ensembl chr 4:171,895,232...172,105,903

G

RAP2C, member of RAS oncogene family

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of RAP2C mRNA

NCBI chr X:135,388,881...135,401,998
Ensembl chr X:135,388,882...135,401,998

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]]; zinc protoporphyrin promotes the reaction [quinocetone results in increased expression of RELA mRNA]
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of RELA protein]
zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased localization of and results in increased activity of RELA protein]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein modified form]]

PMID:19608869 PMID:20131233 PMID:20357190 PMID:21925249 PMID:27375190 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

regulator of cell cycle

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of RGCC mRNA

NCBI chr15:61,071,574...61,084,408
Ensembl chr15:61,071,574...61,084,408

G

SR-related CTD-associated factor 11

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SCAF11 mRNA

NCBI chr 7:129,450,872...129,503,280
Ensembl chr 7:129,417,955...129,503,280

G

secretory carrier membrane protein 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SCAMP1 mRNA

NCBI chr 2:27,168,863...27,251,637
Ensembl chr 2:27,168,864...27,251,742

G

Sec23 homolog B, COPII coat complex component

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SEC23B mRNA

NCBI chr 3:152,392,340...152,434,813
Ensembl chr 3:152,392,308...152,434,800

G

SEL1L adaptor subunit of SYVN1 ubiquitin ligase

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SEL1L mRNA

NCBI chr 6:116,466,163...116,510,436
Ensembl chr 6:116,466,163...116,510,578

G

sirtuin 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Fenofibrate results in increased expression of SIRT1 protein]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 22 member 3

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC22A3 mRNA

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 35, member E1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC35E1 mRNA

NCBI chr16:17,384,980...17,398,227
Ensembl chr16:17,385,030...17,397,310

G

SMCR8-C9orf72 complex subunit

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SMCR8 mRNA

NCBI chr10:45,957,146...45,968,388
Ensembl chr10:45,957,104...45,968,389

G

superoxide dismutase 2

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SOD2 mRNA; zinc protoporphyrin inhibits the reaction [HIF1A protein results in increased activity of SOD2 protein]

PMID:17066447 PMID:22839698

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

spectrin, beta, non-erythrocytic 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SPTBN1 mRNA

NCBI chr14:108,042,629...108,217,884
Ensembl chr14:108,042,629...108,217,836

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to NCF1 protein]]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]]

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

single stranded DNA binding protein 3

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SSBP3 mRNA

NCBI chr 5:126,920,145...127,057,968
Ensembl chr 5:126,919,120...127,056,799

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ST3GAL1 mRNA

NCBI chr 7:100,734,300...100,802,443
Ensembl chr 7:100,734,300...100,745,242

G

signal transducer and activator of transcription 1

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

multiple interactions

EXP
ISO

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]
zinc protoporphyrin inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]

PMID:24095726 PMID:24810525

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

transforming growth factor, beta 1

affects expression
decreases secretion
increases expression

EXP

zinc protoporphyrin affects the expression of TGFB1
zinc protoporphyrin results in decreased secretion of TGFB1 protein
zinc protoporphyrin results in increased expression of TGFB1 protein

PMID:21163135 PMID:23525258 PMID:23704825

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

TIMP metallopeptidase inhibitor 1

affects expression
multiple interactions

EXP
ISO

zinc protoporphyrin affects the expression of TIMP1
zinc protoporphyrin promotes the reaction [ALB protein results in increased expression of TIMP1 protein]

PMID:21163135 PMID:23704825

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

toll-like receptor 2

multiple interactions

EXP

zinc protoporphyrin promotes the reaction [TLR2 protein binds to MYD88 protein]

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

toll-like receptor 4

multiple interactions

EXP

zinc protoporphyrin promotes the reaction [TLR4 protein binds to MYD88 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [cilostazol results in decreased susceptibility to TNF protein]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to NCF1 protein]]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of TNF mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of TNF protein; zinc protoporphyrin inhibits the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; zinc protoporphyrin inhibits the reaction [naringenin results in decreased activity of TNF protein]; zinc protoporphyrin inhibits the reaction [perflexane inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of TNF protein]]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF mRNA]; zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF protein]
zinc protoporphyrin inhibits the reaction [8-oxoberberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased localization of and results in increased activity of RELA protein]]; zinc protoporphyrin inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]

PMID:19608869 PMID:20052772 PMID:20131233 PMID:20360627 PMID:21660147 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 1A

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]]

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

trinucleotide repeat containing adaptor 6A

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of TNRC6A mRNA

NCBI chr 1:186,992,457...187,146,764
Ensembl chr 1:186,992,504...187,146,756

G

toll interacting protein

decreases expression

EXP

zinc protoporphyrin results in decreased expression of TOLLIP protein

NCBI chr 1:206,391,120...206,413,809
Ensembl chr 1:206,380,308...206,411,988

G

tumor protein p53

multiple interactions

ISO
EXP

[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TP53 protein]
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in decreased expression of TP53 protein]
zinc protoporphyrin inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]

PMID:18042465 PMID:20357190 PMID:22763982

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

TNF receptor associated factor 6

multiple interactions

EXP

zinc protoporphyrin promotes the reaction [TRAF6 protein binds to MYD88 protein]

NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328

G

UBX domain protein 2A

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of UBXN2A mRNA

NCBI chr 6:33,603,804...33,645,958
Ensembl chr 6:33,603,804...33,632,202
Ensembl chr20:33,603,804...33,632,202

G

ubiquitin specific peptidase 13

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of USP13 mRNA

NCBI chr 2:117,502,811...117,617,049
Ensembl chr 2:117,505,122...117,630,161

G

ubiquitin specific peptidase 34

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of USP34 mRNA

NCBI chr14:101,487,110...101,677,519
Ensembl chr14:101,487,153...101,678,632

G

vascular cell adhesion molecule 1

multiple interactions

ISO
EXP

zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; zinc protoporphyrin inhibits the reaction [HMOX1 protein inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of VCAM1 mRNA]

PMID:19608869 PMID:23892052

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

vitamin D receptor

affects abundance

ISO

VDR gene polymorphism affects the abundance of zinc protoporphyrin

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757

G

VPS33A core subunit of CORVET and HOPS complexes

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of VPS33A mRNA

NCBI chr12:38,685,484...38,710,668
Ensembl chr12:38,685,538...38,712,277

G

WD repeat and SOCS box-containing 2

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of WSB2 mRNA

NCBI chr12:44,878,483...44,899,474
Ensembl chr12:44,878,509...44,899,474

G

zinc finger protein 36

multiple interactions

ISO

zinc protoporphyrin inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:92,796,628...92,799,108

G

zinc finger protein 827

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ZNF827 mRNA

NCBI chr19:45,624,849...45,791,739
Ensembl chr19:45,614,604...45,844,430

G

zinc finger FYVE-type containing 16

multiple interactions

ISO

[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ZFYVE16 mRNA

NCBI chr 2:25,448,264...25,495,180
Ensembl chr 2:25,448,829...25,483,295

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
role	20844
biological role	20831
biochemical role	19888
cofactor	16878
porphyrins	394
metalloporphyrin	348
15,17(3)-seco-F430-17(3)-acid	0
Fe-coproporphyrin III	0
Zincmethylphyrin I	0
Zincphyrin	0
cobalt(II)-factor III	0
cobalt(II)-factor IV	0
cobalt-precorrin-2	0
cobalt-precorrin-3	0
cobalt-sirohydrochlorin	0
heme +	233
magnesium porphyrin +	6
metallochlorin +	0
metalloprotoporphyrin +	345
nickel-sirohydrochlorin	0
nickel-sirohydrochlorin a,c-diamide	0
palladium porphyrin +	0
platinum porphyrin +	0
zinc porphyrin +	158
Path 2
Term	Annotations
CHEBI ontology	20874
subatomic particle	20883
composite particle	20883
hadron	20872
baryon	20883
nucleon	20872
atomic nucleus	20883
atom	20872
main group element atom	20796
p-block element atom	20796
carbon group element atom	20712
carbon atom	20706
organic molecular entity	20706
organic molecule	20499
organic cyclic compound	20390
organic heterocyclic compound	19381
organonitrogen heterocyclic compound	18491
polypyrrole	716
tetrapyrrole	604
cyclic tetrapyrrole	476
porphyrins	394
metalloporphyrin	348
15,17(3)-seco-F430-17(3)-acid	0
Fe-coproporphyrin III	0
Zincmethylphyrin I	0
Zincphyrin	0
cobalt(II)-factor III	0
cobalt(II)-factor IV	0
cobalt-precorrin-2	0
cobalt-precorrin-3	0
cobalt-sirohydrochlorin	0
heme +	233
magnesium porphyrin +	6
metallochlorin +	0
metalloprotoporphyrin +	345
nickel-sirohydrochlorin	0
nickel-sirohydrochlorin a,c-diamide	0
palladium porphyrin +	0
platinum porphyrin +	0
zinc porphyrin +	158

paths to the root