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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:edrophonium
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Accession:CHEBI:251408 term browser browse the term
Definition:A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Synonyms:exact_synonym: N-ethyl-3-hydroxy-N,N-dimethylanilinium
 related_synonym: (3-hydroxyphenyl)dimethylethylammonium;   3-hydroxy-N,N-dimethyl-N-ethylanilinium;   EDROPHONIUM ION;   Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium;   Formula=C10H16NO;   InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1;   InChIKey=VWLHWLSRQJQWRG-UHFFFAOYSA-O;   N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium;   SMILES=CC[N+](C)(C)c1cccc(O)c1
 alt_id: CHEBI:42376;   CHEBI:4758
 xref: Beilstein:3905622;   CAS:312-48-1;   DrugBank:DB01010;   Drug_Central:988;   KEGG:C06976;   LINCS:LSM-5867
 xref_mesh: MESH:D004491
 xref: PDBeChem:EDR;   PMID:7488499


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edrophonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO Edrophonium binds to and results in decreased activity of ACHE protein; Edrophonium inhibits the reaction [asoxime chloride inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein]]; Edrophonium inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Edrophonium inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Edrophonium promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
Edrophonium results in decreased activity of ACHE protein		 CTD PMID:25522658 PMID:27297626 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO Edrophonium binds to and results in decreased activity of BCHE protein CTD PMID:31173753 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          diagnostic agent 785
            edrophonium 2
              edrophonium chloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  ammonium 8312
                                    ammonium ion derivative 8307
                                      quaternary ammonium ion 5295
                                        edrophonium 2
                                          edrophonium chloride 0
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