CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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| Term: | lead atom |
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| Accession: | CHEBI:25016
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browse the term
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| Definition: | A carbon group element atom that has formula Pb. |
| Synonyms: | related_synonym: | 82Pb; Blei; Pb; lead; plomb; plomo; plumbum |
| | xref: | WebElements:Pb; kegg.compound:C06696 |
| | chemrof_inchi: | InChI=1S/Pb |
| | chemrof_formula: | Pb |
| | chemrof_inchikey: | WABPQHHGFIMREM-UHFFFAOYSA-N |
| | chemrof_smiles: | [Pb] |
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Gp6
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glycoprotein 6 platelet
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decreases methylation
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ISO
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Lead decreases methylation of the GP6 gene in umbilical cord blood
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RGD |
PMID:29492281 |
RGD:401794439 |
NCBI chr 7:4,365,852...4,400,849
Ensembl chr 7:4,366,964...4,400,743
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Xrcc1
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X-ray repair complementing defective repair in Chinese hamster cells 1
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decreases response to substance
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ISO
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XRCC1 protein results in decreased susceptibility to lead chromate
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CTD |
PMID:16714390 |
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NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865
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1810055G02Rik
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RIKEN cDNA 1810055G02 gene
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increases expression
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ISO
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lead acetate results in increased expression of C11ORF24 mRNA
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CTD |
PMID:38568856 |
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NCBI chr19:3,758,343...3,767,882
Ensembl chr19:3,758,293...3,767,881
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2010003K11Rik
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RIKEN cDNA 2010003K11 gene
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decreases expression
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ISO
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lead acetate results in decreased expression of C11ORF86 mRNA
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CTD |
PMID:38568856 |
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NCBI chr19:4,546,816...4,548,611
Ensembl chr19:4,546,816...4,548,611
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5430425K12Rik
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RIKEN cDNA 5430425K12 gene
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increases expression
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ISO
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lead acetate results in increased expression of LUCAT1 mRNA
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CTD |
PMID:27562236 PMID:38568856 |
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NCBI chr13:81,088,522...81,096,716
Ensembl chr13:81,088,530...81,096,718
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6820408C15Rik
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RIKEN cDNA 6820408C15 gene
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decreases expression
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ISO
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lead acetate results in decreased expression of C20ORF96 mRNA
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CTD |
PMID:38568856 |
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NCBI chr 2:152,257,507...152,286,256
Ensembl chr 2:152,257,507...152,286,250
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A2m
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alpha-2-macroglobulin
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affects expression decreases expression
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ISO
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lead acetate affects the expression of A2M mRNA lead acetate results in decreased expression of A2M mRNA
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CTD |
PMID:21864555 PMID:22641619 |
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NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186
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Aadat
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aminoadipate aminotransferase
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increases expression
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ISO
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lead acetate results in increased expression of AADAT mRNA
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CTD |
PMID:22641619 |
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NCBI chr 8:60,958,877...60,998,711
Ensembl chr 8:60,958,966...60,998,711
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Aars1
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alanyl-tRNA synthetase 1
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increases expression
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ISO
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lead acetate results in increased expression of AARS1 mRNA
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CTD |
PMID:11578147 |
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NCBI chr 8:111,759,781...111,784,237
Ensembl chr 8:111,759,776...111,784,296
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Abca1
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ATP-binding cassette, sub-family A member 1
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increases expression
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ISO
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lead acetate results in increased expression of ABCA1 mRNA; lead acetate results in increased expression of ABCA1 protein
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CTD |
PMID:29908845 |
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NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
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Abca6
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ATP-binding cassette, sub-family A member 6
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decreases expression
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ISO
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lead acetate results in decreased expression of ABCA6 mRNA
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CTD |
PMID:38568856 |
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NCBI chr11:110,065,464...110,142,811
Ensembl chr11:110,067,646...110,142,602
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Abca9
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ATP-binding cassette, sub-family A member 9
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decreases expression
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ISO
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lead acetate results in decreased expression of ABCA9 mRNA
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CTD |
PMID:38568856 |
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NCBI chr11:109,990,919...110,059,532
Ensembl chr11:109,991,575...110,059,022
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Abcc1
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ATP-binding cassette, sub-family C member 1
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increases expression affects export
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ISO EXP
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lead acetate results in increased expression of ABCC1 mRNA; lead acetate results in increased expression of ABCC1 protein ABCC1 protein affects the export of lead acetate
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CTD |
PMID:23274417 PMID:24598511 PMID:27236077 |
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NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
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Abcc2
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ATP-binding cassette, sub-family C member 2
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increases expression
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ISO
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lead acetate results in increased expression of ABCC2 mRNA
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CTD |
PMID:38568856 |
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NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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Abcd4
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ATP-binding cassette, sub-family D member 4
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decreases expression
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ISO
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lead acetate results in decreased expression of ABCD4 mRNA
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CTD |
PMID:38568856 |
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NCBI chr12:84,648,634...84,664,259
Ensembl chr12:84,648,238...84,664,187
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Abce1
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ATP-binding cassette, sub-family E member 1
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increases expression
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ISO
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lead acetate results in increased expression of ABCE1 mRNA
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CTD |
PMID:11578147 |
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NCBI chr 8:80,410,071...80,438,369
Ensembl chr 8:80,410,091...80,438,369
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Abcg2
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ATP binding cassette subfamily G member 2 (Junior blood group)
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increases expression
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ISO
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lead acetate results in increased expression of ABCG2 mRNA
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CTD |
PMID:22641619 |
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NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661
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Abhd15
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abhydrolase domain containing 15
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increases expression
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EXP
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lead acetate results in increased expression of ABHD15 mRNA
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CTD |
PMID:22609695 |
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NCBI chr11:77,405,943...77,411,454
Ensembl chr11:77,405,947...77,429,433
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Ablim3
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actin binding LIM protein family, member 3
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increases expression
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ISO
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lead acetate results in increased expression of ABLIM3 mRNA
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CTD |
PMID:38568856 |
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NCBI chr18:61,932,463...62,044,956
Ensembl chr18:61,932,463...62,044,895
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Acaca
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acetyl-Coenzyme A carboxylase alpha
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decreases expression
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EXP
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lead acetate results in decreased expression of ACACA mRNA
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CTD |
PMID:33932463 |
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NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
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Acad8
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acyl-Coenzyme A dehydrogenase family, member 8
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decreases expression
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ISO
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lead acetate results in decreased expression of ACAD8 mRNA
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CTD |
PMID:38568856 |
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NCBI chr 9:26,885,434...26,910,872
Ensembl chr 9:26,885,431...26,910,862
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Acan
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aggrecan
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increases expression multiple interactions
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EXP
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lead acetate results in increased expression of ACAN mRNA BMP2 promotes the reaction [lead acetate results in increased expression of ACAN mRNA]; lead acetate promotes the reaction [BMP2 results in increased expression of ACAN mRNA]
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CTD |
PMID:17805416 |
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NCBI chr 7:78,702,974...78,764,847
Ensembl chr 7:78,703,231...78,764,847
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Acat1
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acetyl-Coenzyme A acetyltransferase 1
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decreases expression
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EXP
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lead acetate results in decreased expression of ACAT1 mRNA
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CTD |
PMID:21829687 |
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NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
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Acat2
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acetyl-Coenzyme A acetyltransferase 2
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decreases expression
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EXP
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lead acetate results in decreased expression of ACAT2 mRNA
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CTD |
PMID:21829687 |
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NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634
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Ace
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angiotensin I converting enzyme
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affects expression
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ISO
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lead acetate affects the expression of ACE mRNA
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CTD |
PMID:21864555 PMID:22641619 |
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NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
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Ace2
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angiotensin converting enzyme 2
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decreases expression
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EXP
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lead acetate results in decreased expression of ACE2 mRNA
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CTD |
PMID:22613225 |
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NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416
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Acer2
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alkaline ceramidase 2
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increases expression
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ISO
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lead acetate results in increased expression of ACER2 mRNA
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CTD |
PMID:22641619 |
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NCBI chr 4:86,792,585...86,853,059
Ensembl chr 4:86,792,633...86,853,059
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Ache
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acetylcholinesterase
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decreases expression decreases activity multiple interactions increases activity
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EXP ISO
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lead acetate results in decreased expression of ACHE protein lead acetate results in decreased activity of ACHE protein [lead acetate results in increased abundance of Lead] which results in decreased activity of ACHE protein; [lead acetate results in increased abundance of Lead] which results in increased activity of ACHE protein; Biological Factors inhibits the reaction [lead acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [lead acetate results in decreased activity of ACHE protein]; ferulic acid inhibits the reaction [lead acetate results in increased activity of ACHE protein]; Plant Preparations inhibits the reaction [lead acetate results in decreased activity of ACHE protein]; Tannic Acid inhibits the reaction [lead acetate results in decreased activity of ACHE protein] puerarin inhibits the reaction [lead acetate results in decreased expression of ACHE protein]
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CTD |
PMID:23501611 PMID:25322819 PMID:25496357 PMID:30703413 PMID:35307918 PMID:35398025 More...
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NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
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Acin1
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apoptotic chromatin condensation inducer 1
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decreases expression
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EXP
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lead acetate results in decreased expression of ACIN1 mRNA
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CTD |
PMID:20542052 |
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NCBI chr14:54,879,618...54,924,422
Ensembl chr14:54,879,618...54,924,388
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Acot11
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acyl-CoA thioesterase 11
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decreases expression
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ISO
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lead acetate results in decreased expression of ACOT11 mRNA
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CTD |
PMID:38568856 |
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NCBI chr 4:106,601,752...106,662,204
Ensembl chr 4:106,601,752...106,662,195
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Acot7
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acyl-CoA thioesterase 7
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increases expression
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EXP
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lead acetate results in increased expression of ACOT7 mRNA
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CTD |
PMID:21829687 |
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NCBI chr 4:152,258,872...152,356,312
Ensembl chr 4:152,262,591...152,356,312
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Acsf2
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acyl-CoA synthetase family member 2
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decreases expression
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ISO
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lead acetate results in decreased expression of ACSF2 mRNA
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CTD |
PMID:38568856 |
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NCBI chr11:94,447,928...94,492,822
Ensembl chr11:94,447,928...94,492,697
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Acsl1
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acyl-CoA synthetase long-chain family member 1
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decreases expression
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ISO
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lead acetate results in decreased expression of ACSL1 mRNA
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CTD |
PMID:38568856 |
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NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088
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Acsl4
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acyl-CoA synthetase long-chain family member 4
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decreases expression multiple interactions
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ISO
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lead acetate results in decreased expression of ACSL4 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of ACSL4 mRNA
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CTD |
PMID:38568856 PMID:39276841 |
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NCBI chr X:141,100,989...141,173,792
Ensembl chr X:141,100,989...141,173,531
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Acsm3
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acyl-CoA synthetase medium-chain family member 3
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affects expression
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ISO
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lead acetate affects the expression of ACSM3 mRNA
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CTD |
PMID:21864555 |
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NCBI chr 7:119,360,106...119,384,119
Ensembl chr 7:119,360,146...119,386,736
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Acsm5
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acyl-CoA synthetase medium-chain family member 5
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decreases expression
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ISO
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lead acetate results in decreased expression of ACSM5 mRNA
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CTD |
PMID:22641619 |
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NCBI chr 7:119,125,354...119,142,583
Ensembl chr 7:119,118,686...119,144,774
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Acta2
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actin alpha 2, smooth muscle, aorta
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multiple interactions
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ISO
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[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ACTA2 protein; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ACTA2 mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ACTA2 mRNA]
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CTD |
PMID:39722890 |
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NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
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Actb
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actin, beta
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affects expression
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EXP
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lead acetate affects the expression of ACTB protein
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CTD |
PMID:20797405 |
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NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509
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Actn4
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actinin alpha 4
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multiple interactions
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EXP
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[lead acetate results in increased abundance of Lead] which results in decreased methylation of ACTN4 intron
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CTD |
PMID:33445541 |
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NCBI chr 7:28,592,673...28,661,799
Ensembl chr 7:28,592,673...28,661,765
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Acvrl1
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activin A receptor, type II-like 1
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increases expression
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EXP
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lead acetate results in increased expression of ACVRL1 mRNA
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CTD |
PMID:22609695 |
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NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217
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Acyp2
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acylphosphatase 2, muscle type
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decreases expression
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EXP
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lead acetate results in decreased expression of ACYP2 mRNA
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CTD |
PMID:20542052 |
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NCBI chr11:30,455,991...30,599,778
Ensembl chr11:30,455,991...30,599,587
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Adam19
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ADAM metallopeptidase domain 19
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decreases expression
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EXP
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lead acetate results in decreased expression of ADAM19 mRNA
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CTD |
PMID:22613225 |
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NCBI chr11:45,945,329...46,038,174
Ensembl chr11:45,946,819...46,038,170
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Adam1a
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a disintegrin and metallopeptidase domain 1a
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increases expression
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ISO
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lead acetate results in increased expression of ADAM1A mRNA
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CTD |
PMID:22641619 |
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NCBI chr 5:121,656,667...121,659,758
Ensembl chr 5:121,656,639...121,660,134
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Adam2
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a disintegrin and metallopeptidase domain 2
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increases methylation
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ISO
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lead acetate results in increased methylation of ADAM2 gene
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CTD |
PMID:29571894 |
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NCBI chr14:66,264,778...66,315,300
Ensembl chr14:66,264,778...66,315,182
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Adam32
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a disintegrin and metallopeptidase domain 32
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increases expression
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ISO
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lead acetate results in increased expression of ADAM32 mRNA
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CTD |
PMID:22641619 |
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NCBI chr 8:25,326,159...25,438,933
Ensembl chr 8:25,326,156...25,438,820
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Adamts1
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ADAM metallopeptidase with thrombospondin type 1 motif 1
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decreases expression
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ISO
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lead acetate results in decreased expression of ADAMTS1 mRNA
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CTD |
PMID:22641619 |
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NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001
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Adamts15
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ADAM metallopeptidase with thrombospondin type 1 motif 15
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decreases expression
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EXP
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lead acetate results in decreased expression of ADAMTS15 mRNA
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CTD |
PMID:22613225 |
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NCBI chr 9:30,810,451...30,833,853
Ensembl chr 9:30,810,451...30,833,748
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Adamts20
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ADAM metallopeptidase with thrombospondin type 1 motif 20
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increases expression
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ISO
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lead acetate results in increased expression of ADAMTS20 mRNA
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CTD |
PMID:22641619 |
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NCBI chr15:94,166,177...94,329,966
Ensembl chr15:94,168,044...94,363,299
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Adamts4
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ADAM metallopeptidase with thrombospondin type 1 motif 4
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increases expression
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ISO
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lead acetate results in increased expression of ADAMTS4 mRNA
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CTD |
PMID:22641619 |
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NCBI chr 1:171,077,698...171,089,836
Ensembl chr 1:171,077,990...171,088,206
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Adamtsl1
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ADAMTS-like 1
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increases expression
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EXP
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lead acetate results in increased expression of ADAMTSL1 mRNA
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CTD |
PMID:20542052 PMID:22613225 |
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NCBI chr 4:85,432,242...86,346,627
Ensembl chr 4:85,432,409...86,346,622
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Adcy8
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adenylate cyclase 8
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increases expression
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EXP ISO
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lead acetate results in increased expression of ADCY8 mRNA
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CTD |
PMID:11578147 PMID:20542052 |
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NCBI chr15:64,570,884...64,794,145
Ensembl chr15:64,568,933...64,794,145
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Adcyap1
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adenylate cyclase activating polypeptide 1
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decreases expression
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EXP
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lead acetate results in decreased expression of ADCYAP1 mRNA
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CTD |
PMID:22613225 |
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NCBI chr17:93,506,448...93,513,967
Ensembl chr17:93,506,445...93,513,965
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| G
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Adgre4
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adhesion G protein-coupled receptor E4
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affects expression
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EXP
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lead acetate affects the expression of ADGRE4 mRNA
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CTD |
PMID:21829687 |
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NCBI chr17:56,056,984...56,160,662
Ensembl chr17:56,056,984...56,160,662
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Adgrf2
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adhesion G protein-coupled receptor F2
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increases expression
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ISO
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lead acetate results in increased expression of ADGRF2 mRNA
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CTD |
PMID:22641619 |
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NCBI chr17:43,004,919...43,054,646
Ensembl chr17:43,007,021...43,053,070
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| G
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Adgrg6
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adhesion G protein-coupled receptor G6
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increases expression
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ISO
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lead acetate results in increased expression of ADGRG6 mRNA
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CTD |
PMID:22641619 |
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NCBI chr10:14,278,327...14,421,467
Ensembl chr10:14,278,327...14,421,403
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Adipoq
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adiponectin, C1Q and collagen domain containing
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decreases expression
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ISO
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lead acetate results in decreased expression of ADIPOQ mRNA
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CTD |
PMID:11578147 |
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NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
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Adipor2
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adiponectin receptor 2
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increases expression
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EXP
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lead acetate results in increased expression of ADIPOR2 mRNA
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CTD |
PMID:21829687 |
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NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665
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| G
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Adk
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adenosine kinase
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decreases expression
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EXP
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lead acetate results in decreased expression of ADK mRNA
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CTD |
PMID:20542052 |
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NCBI chr14:21,102,622...21,498,637
Ensembl chr14:21,102,642...21,498,637
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| G
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Adora1
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adenosine A1 receptor
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multiple interactions increases expression
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ISO
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[lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA; [lead acetate co-treated with Morphine] results in increased expression of ADORA1 protein; [lead acetate results in increased expression of ADORA1 protein] which results in increased abundance of Adenosine lead acetate results in increased expression of ADORA1 mRNA; lead acetate results in increased expression of ADORA1 protein
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CTD |
PMID:20932874 PMID:26478469 |
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NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169
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| G
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Adpgk
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ADP-dependent glucokinase
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decreases expression
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ISO
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lead acetate results in decreased expression of ADPGK mRNA
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CTD |
PMID:22641619 |
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NCBI chr 9:59,198,855...59,223,483
Ensembl chr 9:59,198,841...59,231,335
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| G
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Adra1d
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adrenergic receptor, alpha 1d
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increases expression
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EXP
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lead acetate results in increased expression of ADRA1D mRNA
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CTD |
PMID:22613225 |
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NCBI chr 2:131,387,277...131,404,417
Ensembl chr 2:131,387,770...131,404,203
|
|
| G
|
Adra2b
|
adrenergic receptor, alpha 2b
|
increases expression
|
EXP
|
lead acetate results in increased expression of ADRA2B mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:127,205,099...127,209,141
Ensembl chr 2:127,205,128...127,209,141
|
|
| G
|
Adss1
|
adenylosuccinate synthase 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ADSS1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:112,586,481...112,607,789
Ensembl chr12:112,586,479...112,607,794
|
|
| G
|
Adtrp
|
androgen dependent TFPI regulating protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of ADTRP mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr13:41,916,621...42,001,092
Ensembl chr13:41,916,624...42,001,160
|
|
| G
|
Aebp1
|
AE binding protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of AEBP1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:5,806,085...5,822,248
Ensembl chr11:5,811,947...5,822,088
|
|
| G
|
Afg3l2
|
AFG3-like AAA ATPase 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of AFG3L2 protein
|
CTD |
PMID:38072110 |
|
NCBI chr18:67,537,830...67,582,277
Ensembl chr18:67,537,834...67,582,242
|
|
| G
|
Ager
|
advanced glycosylation end product-specific receptor
|
multiple interactions increases expression
|
ISO
|
sinapinic acid inhibits the reaction [lead acetate results in increased expression of AGER mRNA]
|
CTD |
PMID:37471654 |
|
NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
|
|
| G
|
Agtpbp1
|
ATP/GTP binding protein 1
|
affects expression
|
ISO
|
lead acetate affects the expression of AGTPBP1 protein
|
CTD |
PMID:36539177 |
|
NCBI chr13:59,597,348...59,705,184
Ensembl chr13:59,593,556...59,733,041
|
|
| G
|
Ahnak
|
AHNAK nucleoprotein
|
increases expression
|
EXP
|
lead acetate results in increased expression of AHNAK mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:8,966,640...9,054,299
Ensembl chr19:8,966,648...9,054,278
|
|
| G
|
Ahr
|
aryl-hydrocarbon receptor
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of AHR mRNA; lead acetate results in increased expression of AHR protein [Cadmium Chloride co-treated with Benzo(a)pyrene co-treated with lead acetate] results in increased activity of AHR protein; [lead acetate co-treated with Benzo(a)pyrene] results in increased activity of AHR protein; [sodium arsenite co-treated with Benzo(a)pyrene co-treated with lead acetate] results in increased activity of AHR protein
|
CTD |
PMID:17576166 PMID:29502740 |
|
NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
|
|
| G
|
Ahsp
|
alpha hemoglobin stabilizing protein
|
affects expression
|
ISO
|
lead acetate affects the expression of AHSP mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:127,902,016...127,902,926
Ensembl chr 7:127,901,969...127,902,930
|
|
| G
|
Aif1
|
allograft inflammatory factor 1
|
increases expression multiple interactions decreases expression
|
EXP ISO
|
lead acetate results in increased expression of AIF1 mRNA; lead acetate results in increased expression of AIF1 protein [lead acetate co-treated with Morphine] results in increased expression of AIF1 mRNA lead acetate results in decreased expression of AIF1 mRNA
|
CTD |
PMID:21829687 PMID:26478469 PMID:33862172 PMID:38281554 |
|
NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
|
|
| G
|
Aif1l
|
allograft inflammatory factor 1-like
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of AIF1L mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:31,840,315...31,863,454
Ensembl chr 2:31,840,151...31,863,454
|
|
| G
|
Aifm1
|
apoptosis-inducing factor, mitochondrion-associated 1
|
affects expression decreases expression multiple interactions
|
ISO
|
lead acetate affects the expression of AIFM1 protein lead acetate results in decreased expression of AIFM1 mRNA [amyloid beta-protein (1-40) co-treated with amyloid beta-protein (25-35)] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of AIFM1 protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of AIFM1 protein; [sodium arsenite co-treated with lead acetate] results in increased expression of AIFM1 protein; amyloid beta-protein (1-40) promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of AIFM1 protein]; amyloid beta-protein (25-35) promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of AIFM1 protein]; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of AIFM1 protein]
|
CTD |
PMID:18618274 PMID:23146751 PMID:31874198 PMID:35300571 PMID:38072110 |
|
NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440
|
|
| G
|
Aifm2
|
apoptosis-inducing factor, mitochondrion-associated 2
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of AIFM2 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of AIFM2 mRNA
|
CTD |
PMID:38568856 PMID:39276841 |
|
NCBI chr10:61,551,042...61,575,474
Ensembl chr10:61,551,042...61,575,039
|
|
| G
|
Aipl1
|
aryl hydrocarbon receptor-interacting protein-like 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of AIPL1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:71,919,527...71,933,184
Ensembl chr11:71,918,789...71,928,335
|
|
| G
|
Akap1
|
A kinase anchor protein 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased expression of AKAP1 mRNA
|
CTD |
PMID:33445541 |
|
NCBI chr11:88,721,618...88,755,426
Ensembl chr11:88,721,618...88,755,412
|
|
| G
|
Akap12
|
A kinase anchor protein 12
|
increases expression
|
ISO
|
lead acetate results in increased expression of AKAP12 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:4,216,329...4,309,471
Ensembl chr10:4,216,380...4,309,470
|
|
| G
|
Akap7
|
A kinase anchor protein 7
|
increases expression
|
EXP
|
lead acetate results in increased expression of AKAP7 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr10:25,044,988...25,175,115
Ensembl chr10:25,044,988...25,183,768
|
|
| G
|
Akap8
|
A kinase anchor protein 8
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of AKAP8 gene
|
CTD |
PMID:29571894 |
|
NCBI chr17:32,522,646...32,540,212
Ensembl chr17:32,522,646...32,540,212
|
|
| G
|
Akr1b1
|
aldo-keto reductase family 1 member B
|
increases expression
|
ISO
|
lead acetate results in increased expression of AKR1B1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
|
|
| G
|
Akr1b10
|
aldo-keto reductase family 1, member B10
|
increases expression
|
ISO
|
lead acetate results in increased expression of AKR1B10 mRNA
|
CTD |
PMID:37939567 PMID:38568856 |
|
NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
|
|
| G
|
Akr1c18
|
aldo-keto reductase family 1, member C18
|
increases expression
|
ISO
|
lead acetate results in increased expression of AKR1C3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
|
|
| G
|
Akr1c20
|
aldo-keto reductase family 1, member C20
|
increases expression
|
ISO
|
lead acetate results in increased expression of AKR1C1 mRNA
|
CTD |
PMID:22839698 PMID:38568856 |
|
NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344
|
|
| G
|
Akr1c21
|
aldo-keto reductase family 1, member C21
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of AKR1C2 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of AKR1C2 mRNA
|
CTD |
PMID:22839698 PMID:38568856 PMID:39276841 |
|
NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
|
|
| G
|
Akr1c6
|
aldo-keto reductase family 1, member C6
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of AKR1C1 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr13:4,484,354...4,507,529
Ensembl chr13:4,484,305...4,507,876
|
|
| G
|
Akt1
|
thymoma viral proto-oncogene 1
|
decreases expression decreases phosphorylation multiple interactions increases phosphorylation
|
ISO EXP
|
lead acetate results in decreased expression of AKT1 protein lead acetate results in decreased phosphorylation of AKT1 protein 3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in decreased phosphorylation of AKT1 protein] lead acetate results in increased phosphorylation of AKT1 protein [lead acetate results in increased abundance of Lead] which results in decreased expression of AKT1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of AKT1 protein; Genistein inhibits the reaction [lead acetate results in increased phosphorylation of AKT1 protein]; naringenin inhibits the reaction [lead acetate results in decreased expression of AKT1 protein]
|
CTD |
PMID:24530660 PMID:26542248 PMID:26797587 PMID:36652739 PMID:36807407 PMID:37385299 More...
|
|
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
|
|
| G
|
Akt2
|
thymoma viral proto-oncogene 2
|
increases expression multiple interactions decreases expression
|
EXP ISO
|
lead acetate results in increased expression of AKT2 mRNA sinapinic acid inhibits the reaction [lead acetate results in decreased expression of AKT2 mRNA]
|
CTD |
PMID:22609695 PMID:30980912 PMID:33932463 PMID:38530053 |
|
NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
|
|
| G
|
Alad
|
aminolevulinate, delta-, dehydratase
|
decreases expression multiple interactions decreases activity
|
ISO EXP
|
lead acetate results in decreased expression of ALAD protein Ditiocarb inhibits the reaction [lead acetate results in decreased activity of ALAD protein]; ferulic acid inhibits the reaction [lead acetate results in decreased activity of ALAD protein]; indium trichloride promotes the reaction [lead acetate results in decreased activity of ALAD protein]; lead acetate promotes the reaction [indium trichloride results in decreased activity of ALAD protein]; Vitamin E inhibits the reaction [lead acetate results in decreased activity of ALAD protein] Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein]
|
CTD |
PMID:1032310 PMID:2177232 PMID:2604901 PMID:7084431 PMID:22362014 PMID:23292317 PMID:24345272 PMID:24970117 PMID:25322819 More...
|
|
NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155
|
|
| G
|
Alas1
|
aminolevulinic acid synthase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of ALAS1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853
|
|
| G
|
Alas2
|
aminolevulinic acid synthase 2, erythroid
|
increases expression
|
ISO
|
lead acetate results in increased expression of ALAS2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr X:149,330,443...149,353,614
Ensembl chr X:149,330,371...149,353,634
|
|
| G
|
Alb
|
albumin
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of ALB mRNA; lead acetate results in increased expression of ALB protein [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with nickel chloride co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein
|
CTD |
PMID:17657459 PMID:21549428 PMID:22641619 |
|
NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
|
|
| G
|
Alcam
|
activated leukocyte cell adhesion molecule
|
increases expression
|
EXP
|
lead acetate results in increased expression of ALCAM mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr16:52,069,359...52,273,444
Ensembl chr16:52,069,359...52,274,437
|
|
| G
|
Aldh1a1
|
aldehyde dehydrogenase family 1, subfamily A1
|
increases expression
|
ISO
|
lead acetate results in increased expression of ALDH1A1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
|
|
| G
|
Aldh1a7
|
aldehyde dehydrogenase family 1, subfamily A7
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ALDH1A7 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr19:20,670,318...20,704,920
Ensembl chr19:20,670,317...20,704,926
|
|
| G
|
Aldh1l2
|
aldehyde dehydrogenase 1 family, member L2
|
increases expression
|
EXP
|
lead acetate results in increased expression of ALDH1L2 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr10:83,320,386...83,370,008
Ensembl chr10:83,323,314...83,370,004
|
|
| G
|
Aldh2
|
aldehyde dehydrogenase 2, mitochondrial
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of ALDH2 protein]; [lead acetate results in increased abundance of Lead] which affects the expression of ALDH2 protein; Cyanamide affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of ALDH2 protein]]; Cyanamide affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of ALDH2 protein]
|
CTD |
PMID:31550440 |
|
NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
|
|
| G
|
Aldh3a1
|
aldehyde dehydrogenase family 3, subfamily A1
|
increases expression
|
ISO
|
lead acetate results in increased expression of ALDH3A1 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr11:61,099,336...61,109,244
Ensembl chr11:61,098,363...61,109,247
|
|
| G
|
Aldh3a2
|
aldehyde dehydrogenase family 3, subfamily A2
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of ALDH3A2 mRNA [sodium arsenite co-treated with lead acetate] results in decreased expression of ALDH3A2 protein
|
CTD |
PMID:37939567 PMID:38072110 |
|
NCBI chr11:61,114,240...61,158,267
Ensembl chr11:61,114,243...61,158,290
|
|
| G
|
Aldh3b1
|
aldehyde dehydrogenase 3 family, member B1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ALDH3B1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:3,963,491...3,980,898
Ensembl chr19:3,963,491...3,979,808
|
|
| G
|
Aldh7a1
|
aldehyde dehydrogenase family 7, member A1
|
increases expression
|
EXP
|
lead acetate results in increased expression of ALDH7A1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr18:56,657,794...56,706,112
Ensembl chr18:56,642,759...56,706,023
|
|
| G
|
Aldoa
|
aldolase A, fructose-bisphosphate
|
increases expression
|
EXP
|
lead acetate results in increased expression of ALDOA protein
|
CTD |
PMID:20797405 |
|
NCBI chr 7:126,394,406...126,399,537
Ensembl chr 7:126,394,406...126,399,923
|
|
| G
|
Aldoc
|
aldolase C, fructose-bisphosphate
|
decreases expression multiple interactions
|
EXP ISO
|
lead acetate results in decreased expression of ALDOC protein lead acetate results in decreased expression of ALDOC mRNA [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of ALDOC mRNA; [lead acetate results in increased abundance of Lead] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ALDOC mRNA]
|
CTD |
PMID:20797405 PMID:38157908 PMID:38568856 |
|
NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607
|
|
| G
|
Alms1
|
ALMS1, centrosome and basal body associated
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ALMS1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 6:85,564,482...85,698,973
Ensembl chr 6:85,564,513...85,679,735
|
|
| G
|
Alox15
|
arachidonate 15-lipoxygenase
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of ALOX15 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of ALOX15 mRNA
|
CTD |
PMID:22641619 PMID:39276841 |
|
NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857
|
|
| G
|
Alox5
|
arachidonate 5-lipoxygenase
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ALOX5 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
|
|
| G
|
Alox8
|
arachidonate 8-lipoxygenase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ALOX15B mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:69,074,711...69,088,669
Ensembl chr11:69,074,758...69,088,669
|
|
| G
|
Aloxe3
|
arachidonate lipoxygenase 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of ALOXE3 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr11:69,016,243...69,039,941
Ensembl chr11:69,016,722...69,039,941
|
|
| G
|
Alpl
|
alkaline phosphatase, liver/bone/kidney
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ALPL protein
|
CTD |
PMID:21712424 |
|
NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
|
|
| G
|
Alx3
|
aristaless-like homeobox 3
|
decreases methylation
|
ISO
|
lead acetate results in decreased methylation of ALX3 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 3:107,502,347...107,513,191
Ensembl chr 3:107,502,347...107,513,092
|
|
| G
|
Alyref
|
Aly/REF export factor
|
increases expression
|
ISO
|
lead acetate results in increased expression of ALYREF mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:120,485,330...120,489,342
Ensembl chr11:120,482,947...120,489,191
|
|
| G
|
Amigo1
|
adhesion molecule with Ig like domain 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of AMIGO1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:108,093,605...108,099,602
Ensembl chr 3:108,093,651...108,099,602
|
|
| G
|
Amigo2
|
adhesion molecule with Ig like domain 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of AMIGO2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:97,141,955...97,145,168
Ensembl chr15:97,142,006...97,145,168
|
|
| G
|
Amy2a5
|
amylase 2a5
|
increases expression
|
EXP
|
lead acetate results in increased expression of AMY2A5 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 3:113,156,494...113,166,015
Ensembl chr 3:113,154,494...113,166,153
|
|
| G
|
Angptl1
|
angiopoietin-like 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ANGPTL1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 1:156,666,495...156,688,648
Ensembl chr 1:156,666,132...156,688,648
|
|
| G
|
Ank2
|
ankyrin 2, brain
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ANK2 mRNA
|
CTD |
PMID:33445541 |
|
NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999
|
|
| G
|
Ankrd1
|
ankyrin repeat domain 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of ANKRD1 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr19:36,089,365...36,097,244
Ensembl chr19:36,089,361...36,097,499
|
|
| G
|
Ankrd10
|
ankyrin repeat domain 10
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ANKRD10 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:11,661,581...11,694,617
Ensembl chr 8:11,661,583...11,685,757
|
|
| G
|
Ankrd2
|
ankyrin repeat domain 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ANKRD2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:42,024,358...42,033,550
Ensembl chr19:42,024,439...42,033,549
|
|
| G
|
Ankrd24
|
ankyrin repeat domain 24
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ANKRD24 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr10:81,464,352...81,483,446
Ensembl chr10:81,464,374...81,483,444
|
|
| G
|
Ankrd33b
|
ankyrin repeat domain 33B
|
increases expression
|
EXP
|
lead acetate results in increased expression of ANKRD33B mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr15:31,278,328...31,370,446
Ensembl chr15:31,291,624...31,367,872
|
|
| G
|
Ankrd34a
|
ankyrin repeat domain 34A
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ANKRD34A mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 3:96,503,599...96,507,442
Ensembl chr 3:96,503,952...96,507,091
|
|
| G
|
Ankrd44
|
ankyrin repeat domain 44
|
increases expression
|
ISO
|
lead acetate results in increased expression of ANKRD44 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 1:54,684,499...54,968,142
Ensembl chr 1:54,684,499...54,965,546
|
|
| G
|
Ankzf1
|
ankyrin repeat and zinc finger domain containing 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ANKZF1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:75,168,794...75,176,031
Ensembl chr 1:75,168,795...75,176,031
|
|
| G
|
Ano2
|
anoctamin 2
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of ANO2 exon; [lead acetate results in increased abundance of Lead] which results in decreased methylation of ANO2 intron; [lead acetate results in increased abundance of Lead] which results in decreased methylation of ANO2 promoter
|
CTD |
PMID:33445541 |
|
NCBI chr 6:125,667,382...126,017,115
Ensembl chr 6:125,667,382...126,017,089
|
|
| G
|
Ano4
|
anoctamin 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of ANO4 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr10:88,784,794...89,181,059
Ensembl chr10:88,784,856...89,180,624
|
|
| G
|
Anp32a
|
acidic nuclear phosphoprotein 32 family member A
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of ANP32A exon; [lead acetate results in increased abundance of Lead] which results in decreased methylation of ANP32A intron
|
CTD |
PMID:33445541 |
|
NCBI chr 9:62,248,637...62,286,084
Ensembl chr 9:62,248,575...62,286,094
|
|
| G
|
Antxr2
|
anthrax toxin receptor 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ANTXR2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:98,032,547...98,178,876
Ensembl chr 5:98,030,642...98,178,902
|
|
| G
|
Anxa1
|
annexin A1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ANXA1 mRNA; lead acetate results in decreased expression of ANXA1 protein
|
CTD |
PMID:11578147 |
|
NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
|
|
| G
|
Anxa10
|
annexin A10
|
increases expression
|
ISO
|
lead acetate results in increased expression of ANXA10 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:62,510,076...62,576,227
Ensembl chr 8:62,510,076...62,576,184
|
|
| G
|
Anxa5
|
annexin A5
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of ANXA5 mRNA; lead acetate results in increased expression of ANXA5 protein lead acetate binds to and results in increased activity of ANXA5 protein
|
CTD |
PMID:11578147 |
|
NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043
|
|
| G
|
Ap2a1
|
adaptor-related protein complex 2, alpha 1 subunit
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of AP2A1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 7:44,549,797...44,578,914
Ensembl chr 7:44,549,797...44,578,920
|
|
| G
|
Ap3d1
|
adaptor-related protein complex 3, delta 1 subunit
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of AP3D1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr10:80,542,790...80,578,137
Ensembl chr10:80,542,790...80,578,098
|
|
| G
|
Apaf1
|
apoptotic peptidase activating factor 1
|
multiple interactions increases expression
|
ISO EXP
|
sinapinic acid inhibits the reaction [lead acetate results in increased expression of APAF1 mRNA]
|
CTD |
PMID:20542052 PMID:37471654 PMID:38530053 |
|
NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632
|
|
| G
|
Apba1
|
amyloid beta precursor protein binding family A member 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of APBA1 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr19:23,736,170...23,926,961
Ensembl chr19:23,736,251...23,926,960
|
|
| G
|
Apex1
|
apurinic/apyrimidinic endonuclease 1
|
multiple interactions decreases expression increases expression decreases response to substance
|
ISO
|
[lead acetate results in increased expression of APEX1 protein] which results in increased abundance of Reactive Oxygen Species; APEX1 protein promotes the reaction [lead acetate results in increased expression of CCND1 protein]; APEX1 protein promotes the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; APEX1 protein promotes the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; lead acetate promotes the reaction [APEX1 protein results in increased phosphorylation of MAPK1 protein]; lead acetate promotes the reaction [APEX1 protein results in increased phosphorylation of MAPK3 protein]; lead acetate promotes the reaction [MAPK1 protein modified form binds to APEX1 protein] lead acetate results in decreased expression of APEX1 mRNA lead acetate results in increased expression of APEX1 mRNA APEX1 protein results in decreased susceptibility to lead acetate
|
CTD |
PMID:23370007 PMID:33862172 |
|
NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596
|
|
| G
|
Aph1b
|
aph1 homolog B, gamma secretase subunit
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of APH1B mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:66,682,484...66,704,671
Ensembl chr 9:66,682,484...66,702,772
|
|
| G
|
Api5
|
apoptosis inhibitor 5
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of API5P1 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 2:94,242,073...94,268,490
Ensembl chr 2:94,242,027...94,268,481
|
|
| G
|
Apobec1
|
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of APOBEC1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:122,554,755...122,580,068
Ensembl chr 6:122,554,751...122,579,403
|
|
| G
|
Apoc2
|
apolipoprotein C2
|
increases expression
|
EXP
|
lead acetate results in increased expression of APOC2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:19,405,504...19,411,866
Ensembl chr 7:19,405,504...19,411,866
|
|
| G
|
Apoe
|
apolipoprotein E
|
increases expression multiple interactions increases methylation
|
EXP ISO
|
lead acetate results in increased expression of APOE mRNA [APOE alternative form co-treated with lead acetate] results in increased abundance of lead acetate lead acetate results in increased methylation of APOE gene
|
CTD |
PMID:21829687 PMID:28173832 PMID:29571894 PMID:29746905 |
|
NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
|
|
| G
|
App
|
amyloid beta precursor protein
|
decreases methylation affects expression multiple interactions increases expression
|
ISO EXP
|
lead acetate results in decreased methylation of APP promoter lead acetate affects the expression of APP protein [lead acetate results in increased abundance of Lead] which results in increased expression of APP mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of APP protein lead acetate results in increased expression of APP mRNA; lead acetate results in increased expression of APP protein; lead acetate results in increased expression of APP protein alternative form; lead acetate results in increased expression of APP protein modified form lead acetate results in increased expression of APP mRNA; lead acetate results in increased expression of APP protein; lead acetate results in increased expression of APP protein modified form Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of APP protein modified form] [[lead acetate results in increased abundance of Lead] which co-treated with APP protein modified form] results in decreased expression of SYP protein; [lead acetate co-treated with tolfenamic acid] results in decreased expression of APP mRNA; [lead acetate results in increased abundance of Lead] promotes the reaction [[APP protein co-treated with APP protein modified form] results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [[APP protein co-treated with APP protein modified form] results in decreased expression of SYP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein binds to APP protein modified form]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein binds to APP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form binds to APP protein modified form]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in increased expression of BACE1 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in decreased expression of SYP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in increased expression of BACE1 protein]; [sodium arsenite co-treated with lead acetate] results in increased expression of APP protein; tolfenamic acid inhibits the reaction [lead acetate results in increased expression of APP protein modified form]
|
CTD |
PMID:21117136 PMID:22279679 PMID:22764079 PMID:23867794 PMID:24462621 PMID:24806610 PMID:25088297 PMID:29908845 PMID:31730887 PMID:31843630 PMID:32058320 PMID:36539177 PMID:38072110 More...
|
|
NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
|
|
| G
|
Aprt
|
adenine phosphoribosyl transferase
|
decreases activity
|
ISO
|
lead acetate results in decreased activity of APRT protein
|
CTD |
PMID:19428946 |
|
NCBI chr 8:123,301,376...123,303,646
Ensembl chr 8:123,301,374...123,303,648
|
|
| G
|
Aqp3
|
aquaporin 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of AQP3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183
|
|
| G
|
Ar
|
androgen receptor
|
increases expression
|
EXP
|
lead acetate results in increased expression of AR mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
|
|
| G
|
Arc
|
activity regulated cytoskeletal-associated protein
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of ARC mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of ARC mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of ARC protein; asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of ARC mRNA]; asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of ARC protein]
|
CTD |
PMID:22641619 PMID:27936013 PMID:39947421 |
|
NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419
|
|
| G
|
Arfgap2
|
ARF GTPase activating protein 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ARFGAP2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:91,095,460...91,107,716
Ensembl chr 2:91,095,319...91,107,276
|
|
| G
|
Arfgef2
|
ARF guanine nucleotide exchange factor 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ARFGEF2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:166,647,371...166,739,972
Ensembl chr 2:166,647,508...166,739,972
|
|
| G
|
Arglu1
|
arginine and glutamate rich 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of ARGLU1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:8,716,307...8,741,818
Ensembl chr 8:8,715,075...8,740,521
|
|
| G
|
Arhgap17
|
Rho GTPase activating protein 17
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ARHGAP17 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:122,878,372...122,969,171
Ensembl chr 7:122,878,441...122,969,138
|
|
| G
|
Arhgap24
|
Rho GTPase activating protein 24
|
increases expression
|
EXP
|
lead acetate results in increased expression of ARHGAP24 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:102,355,043...103,053,743
Ensembl chr 5:102,629,257...103,045,803
|
|
| G
|
Arhgap45
|
Rho GTPase activating protein 45
|
increases expression
|
ISO
|
lead acetate results in increased expression of ARHGAP45 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:79,852,505...79,867,305
Ensembl chr10:79,852,487...79,867,306
|
|
| G
|
Arid5b
|
AT-rich interaction domain 5B
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ARID5B mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:67,928,353...68,114,596
Ensembl chr10:67,928,350...68,114,570
|
|
| G
|
Arl1
|
ADP-ribosylation factor-like 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ARL1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr10:88,566,720...88,579,956
Ensembl chr10:88,566,720...88,579,956
|
|
| G
|
Arl8b
|
ADP-ribosylation factor-like 8B
|
increases expression
|
EXP
|
lead acetate results in increased expression of ARL8B mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 6:108,760,020...108,800,684
Ensembl chr 6:108,760,060...108,802,239
|
|
| G
|
Armc9
|
armadillo repeat containing 9
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of ARMC9 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 1:86,082,436...86,207,491
Ensembl chr 1:86,082,502...86,206,006
|
|
| G
|
Arpin
|
actin-related protein 2/3 complex inhibitor
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ARPIN mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:79,575,107...79,585,012
Ensembl chr 7:79,575,109...79,585,107
|
|
| G
|
Arpp21
|
cyclic AMP-regulated phosphoprotein, 21
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ARPP21 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 9:111,894,159...112,065,356
Ensembl chr 9:111,894,159...112,065,006
|
|
| G
|
Arrdc4
|
arrestin domain containing 4
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of ARRDC4 mRNA lead acetate results in increased expression of ARRDC4 mRNA
|
CTD |
PMID:21829687 PMID:22839698 |
|
NCBI chr 7:68,386,742...68,398,986
Ensembl chr 7:68,386,743...68,398,989
|
|
| G
|
Art3
|
ADP-ribosyltransferase 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of ART3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:92,479,659...92,562,487
Ensembl chr 5:92,479,686...92,562,487
|
|
| G
|
Arvcf
|
armadillo repeat gene deleted in velocardiofacial syndrome
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ARVCF mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:18,166,046...18,225,826
Ensembl chr16:18,166,046...18,225,826
|
|
| G
|
Asah1
|
N-acylsphingosine amidohydrolase 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of ASAH1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810
|
|
| G
|
Asap2
|
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of ASAP2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:21,161,369...21,320,172
Ensembl chr12:21,040,460...21,320,172
|
|
| G
|
Asb14
|
ankyrin repeat and SOCS box-containing 14
|
decreases expression
|
ISO EXP
|
lead acetate results in decreased expression of ASB14 mRNA
|
CTD |
PMID:22609695 PMID:22641619 |
|
NCBI chr14:26,616,547...26,638,393
Ensembl chr14:26,616,514...26,637,215
|
|
| G
|
Asb6
|
ankyrin repeat and SOCS box-containing 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of ASB6 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:30,713,109...30,718,312
Ensembl chr 2:30,713,109...30,720,345
|
|
| G
|
Asb9
|
ankyrin repeat and SOCS box-containing 9
|
increases expression
|
EXP
|
lead acetate results in increased expression of ASB9 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr X:163,280,899...163,322,748
Ensembl chr X:163,289,323...163,322,748
|
|
| G
|
Ascc3
|
activating signal cointegrator 1 complex subunit 3
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of ASCC3 protein
|
CTD |
PMID:38072110 |
|
NCBI chr10:50,468,756...50,727,300
Ensembl chr10:50,468,765...50,727,581
|
|
| G
|
Asf1a
|
anti-silencing function 1A histone chaperone
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ASF1A mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr10:53,473,057...53,485,321
Ensembl chr10:53,472,853...53,485,321
|
|
| G
|
Asl
|
argininosuccinate lyase
|
increases expression
|
ISO
|
lead acetate results in increased expression of ASL mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 5:130,040,099...130,053,222
Ensembl chr 5:130,040,099...130,058,088
|
|
| G
|
Asns
|
asparagine synthetase
|
increases expression
|
ISO EXP
|
lead acetate results in increased expression of ASNS mRNA
|
CTD |
PMID:11578147 PMID:25270620 |
|
NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254
|
|
| G
|
Aspa
|
aspartoacylase
|
affects expression
|
ISO
|
lead acetate affects the expression of ASPA protein
|
CTD |
PMID:36539177 |
|
NCBI chr11:73,195,813...73,217,677
Ensembl chr11:73,195,818...73,220,422
|
|
| G
|
Aspdh
|
aspartate dehydrogenase domain containing
|
increases expression
|
ISO
|
lead acetate results in increased expression of ASPDH mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:44,114,859...44,117,175
Ensembl chr 7:44,114,815...44,117,182
|
|
| G
|
Asph
|
aspartate-beta-hydroxylase
|
increases expression
|
ISO
|
lead acetate results in increased expression of ASPH mRNA
|
CTD |
PMID:22839698 PMID:38568856 |
|
NCBI chr 4:9,449,085...9,669,344
Ensembl chr 4:9,448,069...9,669,344
|
|
| G
|
Aspn
|
asporin
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ASPN mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr13:49,697,919...49,721,041
Ensembl chr13:49,697,919...49,721,041
|
|
| G
|
Ass1
|
argininosuccinate synthetase 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ASS1 mRNA
|
CTD |
PMID:11578147 PMID:38568856 |
|
NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684
|
|
| G
|
Atf3
|
activating transcription factor 3
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of ATF3 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
|
|
| G
|
Atf4
|
activating transcription factor 4
|
increases expression multiple interactions decreases expression
|
ISO EXP
|
lead acetate results in increased expression of ATF4 protein [lead acetate results in increased abundance of Lead] which results in increased expression of ATF4 mRNA lead acetate results in decreased expression of ATF4 mRNA
|
CTD |
PMID:22811615 PMID:24260418 PMID:39547369 |
|
NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742
|
|
| G
|
Atf5
|
activating transcription factor 5
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of ATF5 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of ATF5 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of ATF5 protein; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of CLPP mRNA]; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HSPD1 mRNA]; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of LONP1 mRNA]; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of LONP1 protein]; ATF5 protein affects the susceptibility to [lead acetate results in increased abundance of Lead]; ATF5 protein results in decreased susceptibility to [lead acetate results in increased abundance of Lead]
|
CTD |
PMID:38568856 PMID:39547369 |
|
NCBI chr 7:44,461,680...44,466,082
Ensembl chr 7:44,461,680...44,466,082
|
|
| G
|
Atf6
|
activating transcription factor 6
|
increases expression multiple interactions
|
ISO EXP
|
lead acetate results in increased expression of ATF6 mRNA sinapinic acid inhibits the reaction [lead acetate results in increased expression of ATF6 mRNA]
|
CTD |
PMID:11578147 PMID:21829687 PMID:38530053 |
|
NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340
|
|
| G
|
Atf7
|
activating transcription factor 7
|
increases expression
|
EXP
|
lead acetate results in increased expression of ATF7 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:102,434,381...102,533,899
Ensembl chr15:102,434,381...102,533,899
|
|
| G
|
Atg13
|
autophagy related 13
|
affects expression
|
ISO
|
lead acetate affects the expression of ATG13 protein
|
CTD |
PMID:36539177 |
|
NCBI chr 2:91,504,957...91,540,947
Ensembl chr 2:91,504,963...91,540,921
|
|
| G
|
Atg5
|
autophagy related 5
|
multiple interactions
|
EXP ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ATG5 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of ATG5 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of ATG5 protein
|
CTD |
PMID:33445541 PMID:36652739 |
|
NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287
|
|
| G
|
Atg7
|
autophagy related 7
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ATG7 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575
|
|
| G
|
Atl1
|
atlastin GTPase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of ATL1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:69,939,879...70,010,859
Ensembl chr12:69,939,388...70,013,191
|
|
| G
|
Atm
|
ataxia telangiectasia mutated
|
multiple interactions increases phosphorylation
|
ISO EXP
|
ATM protein affects the reaction [lead acetate results in decreased expression of COX4 protein]; lead acetate promotes the reaction [PINK1 protein binds to ATM protein] [lead acetate results in increased abundance of Lead] which results in increased expression of ATM mRNA lead acetate results in increased phosphorylation of ATM protein
|
CTD |
PMID:29660402 PMID:39276841 |
|
NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
|
|
| G
|
Atox1
|
antioxidant 1 copper chaperone
|
increases expression
|
ISO
|
lead acetate results in increased expression of ATOX1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:55,337,463...55,352,034
Ensembl chr11:55,337,467...55,352,065
|
|
| G
|
Atp12a
|
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
|
increases expression
|
EXP
|
lead acetate results in increased expression of ATP12A mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr14:56,602,525...56,626,008
Ensembl chr14:56,602,525...56,626,007
|
|
| G
|
Atp1a1
|
ATPase, Na+/K+ transporting, alpha 1 polypeptide
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ATP1A1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000
|
|
| G
|
Atp1b2
|
ATPase, Na+/K+ transporting, beta 2 polypeptide
|
increases expression
|
ISO
|
lead acetate results in increased expression of ATP1B2 mRNA
|
CTD |
PMID:22160880 |
|
NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768
|
|
| G
|
Atp6v1a
|
ATPase, H+ transporting, lysosomal V1 subunit A
|
affects expression
|
EXP
|
lead acetate affects the expression of ATP6V1A protein
|
CTD |
PMID:20797405 |
|
NCBI chr16:43,905,765...43,960,055
Ensembl chr16:43,905,765...43,960,068
|
|
| G
|
Atp6v1b1
|
ATPase, H+ transporting, lysosomal V1 subunit B1
|
increases expression
|
EXP
|
lead acetate results in increased expression of ATP6V1B1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:83,719,999...83,735,837
Ensembl chr 6:83,719,972...83,735,837
|
|
| G
|
Atp6v1b2
|
ATPase, H+ transporting, lysosomal V1 subunit B2
|
increases expression
|
ISO EXP
|
lead acetate results in increased expression of ATP6V1B2 mRNA
|
CTD |
PMID:11578147 PMID:25270620 |
|
NCBI chr 8:69,541,388...69,566,370
Ensembl chr 8:69,541,298...69,566,363
|
|
| G
|
Atp6v1e1
|
ATPase, H+ transporting, lysosomal V1 subunit E1
|
increases expression
|
EXP
|
lead acetate results in increased expression of ATP6V1E1 protein
|
CTD |
PMID:20797405 |
|
NCBI chr 6:120,772,205...120,799,659
Ensembl chr 6:120,771,266...120,799,754
|
|
| G
|
Atp6v1g2
|
ATPase, H+ transporting, lysosomal V1 subunit G2
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ATP6V1G2 mRNA
|
CTD |
PMID:36642386 |
|
NCBI chr17:35,453,910...35,457,743
Ensembl chr17:35,452,636...35,457,743
|
|
| G
|
Atp6v1h
|
ATPase, H+ transporting, lysosomal V1 subunit H
|
increases expression
|
EXP
|
lead acetate results in increased expression of ATP6V1H mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 1:5,153,201...5,233,438
Ensembl chr 1:5,140,241...5,232,752
|
|
| G
|
Atp7a
|
ATPase, copper transporting, alpha polypeptide
|
multiple interactions increases expression decreases expression
|
EXP ISO
|
[[cupric chloride results in increased abundance of Copper] co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of ATP7A protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of ATP7A protein ATP7A protein modified form inhibits the reaction [lead acetate binds to HSPA5 protein] lead acetate results in increased expression of ATP7A mRNA lead acetate results in decreased expression of ATP7A mRNA; lead acetate results in decreased expression of ATP7A protein
|
CTD |
PMID:10702365 PMID:24316150 PMID:25579025 PMID:40010429 |
|
NCBI chr X:105,070,830...105,171,766
Ensembl chr X:105,070,882...105,168,532
|
|
| G
|
Atp7b
|
ATPase, copper transporting, beta polypeptide
|
multiple interactions
|
EXP
|
[[cupric chloride results in increased abundance of Copper] co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of ATP7B protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of ATP7B protein
|
CTD |
PMID:40010429 |
|
NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321
|
|
| G
|
Atp8a1
|
ATPase phospholipid transporting 8A1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ATP8A1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:67,775,482...68,004,822
Ensembl chr 5:67,775,483...68,004,777
|
|
| G
|
Atp8b3
|
ATPase, class I, type 8B, member 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ATP8B3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:80,355,418...80,374,987
Ensembl chr10:80,355,418...80,374,958
|
|
| G
|
Atp9b
|
ATPase, class II, type 9B
|
increases expression
|
EXP
|
lead acetate results in increased expression of ATP9B mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr18:80,777,356...80,977,291
Ensembl chr18:80,777,356...80,977,275
|
|
| G
|
Atxn1
|
ataxin 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ATXN1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr13:45,703,231...46,118,467
Ensembl chr13:45,703,231...46,118,484
|
|
| G
|
Auh
|
AU RNA binding protein/enoyl-coenzyme A hydratase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of AUH mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:52,989,155...53,083,742
Ensembl chr13:52,989,155...53,083,717
|
|
| G
|
Aurka
|
aurora kinase A
|
increases expression
|
EXP
|
lead acetate results in increased expression of AURKA mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455
|
|
| G
|
Aurkc
|
aurora kinase C
|
increases expression
|
EXP
|
lead acetate results in increased expression of AURKC mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:6,998,346...7,006,090
Ensembl chr 7:6,998,299...7,006,090
|
|
| G
|
B3galt2
|
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of B3GALT2 mRNA
|
CTD |
PMID:27562236 |
|
NCBI chr 1:143,516,435...143,525,675
Ensembl chr 1:143,516,402...143,530,352
|
|
| G
|
B3galt6
|
UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6
|
decreases methylation
|
ISO
|
lead acetate results in decreased methylation of B3GALT6 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 4:156,073,923...156,077,135
Ensembl chr 4:156,073,923...156,077,106
|
|
| G
|
B3gat2
|
beta-1,3-glucuronyltransferase 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of B3GAT2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:23,801,007...23,886,946
Ensembl chr 1:23,800,834...23,888,239
|
|
| G
|
B3gnt3
|
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of B3GNT3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:72,144,017...72,155,270
Ensembl chr 8:72,143,400...72,154,433
|
|
| G
|
B3gnt4
|
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of B3GNT4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:123,646,519...123,649,945
Ensembl chr 5:123,648,523...123,649,945
|
|
| G
|
B4galnt1
|
beta-1,4-N-acetyl-galactosaminyl transferase 1
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of B4GALNT1 mRNA lead acetate results in increased expression of B4GALNT1 mRNA
|
CTD |
PMID:22609695 PMID:37939567 PMID:38568856 |
|
NCBI chr10:127,001,025...127,008,209
Ensembl chr10:127,001,094...127,008,199
|
|
| G
|
B4galnt2
|
beta-1,4-N-acetyl-galactosaminyl transferase 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of B4GALNT2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:95,754,385...95,805,786
Ensembl chr11:95,756,769...95,805,717
|
|
| G
|
Baat
|
bile acid-Coenzyme A: amino acid N-acyltransferase
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of BAAT mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:49,489,416...49,507,915
Ensembl chr 4:49,489,422...49,506,557
|
|
| G
|
Bace1
|
beta-site APP cleaving enzyme 1
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of BACE1 mRNA; lead acetate results in increased expression of BACE1 protein [lead acetate results in increased abundance of Lead] which results in increased expression of BACE1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of BACE1 protein [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in increased expression of BACE1 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in increased expression of BACE1 protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of BACE1 protein
|
CTD |
PMID:23867794 PMID:29908845 PMID:31730887 PMID:31843630 PMID:32058320 |
|
NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697
|
|
| G
|
Bach1
|
BTB and CNC homology 1, basic leucine zipper transcription factor 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of BACH1 protein; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of DLG1 protein]; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NDUFB8 protein]; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SDHB protein]; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SYN1 protein]; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of UQCRC2 protein]; BACH1 gene mutant form results in decreased susceptibility to [lead acetate results in increased abundance of Lead]; Hemin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BACH1 protein] [lead acetate results in increased abundance of Lead] which results in increased expression of BACH1 mRNA
|
CTD |
PMID:36096218 PMID:39276841 |
|
NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234
|
|
| G
|
Bad
|
BCL2-associated agonist of cell death
|
affects expression
|
ISO
|
lead acetate affects the expression of BAD protein
|
CTD |
PMID:18618274 |
|
NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
|
|
| G
|
Bag1
|
BCL2-associated athanogene 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of BAG1 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 4:40,936,398...40,948,294
Ensembl chr 4:40,936,398...40,948,294
|
|
| G
|
Bag3
|
BCL2-associated athanogene 3
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of BAG3 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 7:128,125,307...128,148,705
Ensembl chr 7:128,125,340...128,148,705
|
|
| G
|
Baiap2l1
|
BAI1-associated protein 2-like 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of BAIAP2L1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:144,201,335...144,294,922
Ensembl chr 5:144,201,336...144,294,922
|
|
| G
|
Bak1
|
BCL2-antagonist/killer 1
|
multiple interactions
|
ISO
|
[[amyloid beta-protein (1-40) co-treated with amyloid beta-protein (25-35)] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of BAK1 protein; [[lead acetate results in increased abundance of Lead] which co-treated with amyloid beta-protein (25-35)] results in increased expression of BAK1 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of BAK1 protein
|
CTD |
PMID:35300571 |
|
NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
|
|
| G
|
Bambi
|
BMP and activin membrane-bound inhibitor
|
increases expression
|
ISO
|
lead acetate results in increased expression of BAMBI mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404
|
|
| G
|
Barhl1
|
BarH like homeobox 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of BARHL1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:28,797,692...28,807,996
Ensembl chr 2:28,797,691...28,806,680
|
|
| G
|
Bax
|
BCL2-associated X protein
|
multiple interactions increases expression affects expression decreases expression
|
ISO EXP
|
5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in increased expression of BAX protein]; [[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in increased expression of BAX protein; [Cadmium Chloride co-treated with lead acetate] results in increased expression of BAX protein; [lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of BAX protein; Acetylcysteine affects the reaction [lead acetate results in increased expression of BAX protein]; Ascorbic Acid inhibits the reaction [lead acetate results in increased expression of BAX protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of BAX protein]; Genistein affects the reaction [lead acetate results in increased expression of BAX protein]; Hemin inhibits the reaction [lead acetate results in increased expression of BAX protein]; lead acetate promotes the reaction [Zinc Oxide results in increased expression of BAX mRNA]; Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of BAX mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of BAX mRNA] lead acetate results in increased expression of BAX mRNA; lead acetate results in increased expression of BAX protein NFE2L2 protein inhibits the reaction [lead acetate results in increased expression of BAX protein] lead acetate affects the expression of BAX protein lead acetate results in decreased expression of BAX mRNA; lead acetate results in decreased expression of BAX protein [cupric chloride results in increased abundance of Copper] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[cupric chloride results in increased abundance of Copper] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein]]; mitoquinone inhibits the reaction [[cupric chloride results in increased abundance of Copper] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein]]
|
CTD |
PMID:17959157 PMID:23086308 PMID:23146751 PMID:24960054 PMID:25031709 PMID:26396915 PMID:26498409 PMID:26542248 PMID:26797587 PMID:29797346 PMID:32116774 PMID:32208856 PMID:33242459 PMID:34553816 PMID:36925031 PMID:37471654 PMID:38530053 PMID:40010429 More...
|
|
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
|
|
| G
|
Bbx
|
bobby sox HMG box containing
|
decreases methylation
|
ISO
|
lead acetate results in decreased methylation of BBX gene
|
CTD |
PMID:29571894 |
|
NCBI chr16:50,012,207...50,252,829
Ensembl chr16:50,012,207...50,252,753
|
|
| G
|
BC028528
|
cDNA sequence BC028528
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of C1ORF54 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:95,789,665...95,800,186
Ensembl chr 3:95,791,266...95,799,317
|
|
| G
|
Bcas3
|
BCAS3 microtubule associated cell migration factor
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of BCAS3 intron
|
CTD |
PMID:33445541 |
|
NCBI chr11:85,243,611...85,716,884
Ensembl chr11:85,243,993...85,716,884
|
|
| G
|
Bcat1
|
branched chain aminotransferase 1, cytosolic
|
increases expression
|
ISO EXP
|
lead acetate results in increased expression of BCAT1 mRNA
|
CTD |
PMID:11578147 PMID:25270620 |
|
NCBI chr 6:144,939,561...145,021,883
Ensembl chr 6:144,939,561...145,021,910
|
|
| G
|
Bccip
|
BRCA2 and CDKN1A interacting protein
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of BCCIP mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:133,311,045...133,322,874
Ensembl chr 7:133,311,062...133,322,874
|
|
| G
|
Bche
|
butyrylcholinesterase
|
multiple interactions increases activity
|
ISO
|
ferulic acid promotes the reaction [lead acetate results in increased activity of BCHE protein]
|
CTD |
PMID:25322819 |
|
NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
|
|
| G
|
Bcl10
|
B cell leukemia/lymphoma 10
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of BCL10 mRNA [sodium arsenite co-treated with lead acetate] results in decreased expression of BCL10 protein
|
CTD |
PMID:20542052 PMID:38072110 |
|
NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111
|
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| G
|
Bcl2
|
B cell leukemia/lymphoma 2
|
multiple interactions decreases expression affects expression increases expression
|
ISO EXP
|
5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]; [[lead acetate results in increased abundance of Lead] which co-treated with Carbenoxolone] results in decreased expression of BCL2 protein; [Cadmium Chloride co-treated with lead acetate] results in decreased expression of BCL2 protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of BCL2 protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of BCL2 protein; Ascorbic Acid promotes the reaction [lead acetate results in increased expression of BCL2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]; Genistein inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]; Hemin inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]; lead acetate promotes the reaction [Zinc Oxide results in decreased expression of BCL2 mRNA]; Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BCL2 protein]; sinapinic acid inhibits the reaction [lead acetate results in decreased expression of BCL2 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BCL2 protein]; Zinc Oxide promotes the reaction [lead acetate results in decreased expression of BCL2 mRNA] [[cupric chloride results in increased abundance of Copper] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of BCL2 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of BCL2 protein; mitoquinone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of BCL2 protein] NFE2L2 protein inhibits the reaction [lead acetate results in decreased expression of BCL2 protein] lead acetate affects the expression of BCL2 protein lead acetate results in decreased expression of BCL2 mRNA; lead acetate results in decreased expression of BCL2 protein lead acetate results in increased expression of BCL2 mRNA lead acetate affects the expression of BCL2 mRNA
|
CTD |
PMID:17959157 PMID:18618274 PMID:19026729 PMID:22609695 PMID:23086308 PMID:23146751 PMID:24960054 PMID:25031709 PMID:26396915 PMID:26498409 PMID:26542248 PMID:26797587 PMID:29797346 PMID:32116774 PMID:32208856 PMID:33242459 PMID:34553816 PMID:36925031 PMID:37471654 PMID:38530053 PMID:40010429 More...
|
|
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
|
|
| G
|
Bcl2l1
|
BCL2-like 1
|
affects expression multiple interactions
|
ISO
|
lead acetate affects the expression of BCL2L1 protein HMOX1 protein affects the reaction [lead acetate affects the expression of BCL2L1 protein]
|
CTD |
PMID:26542248 |
|
NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
|
|
| G
|
Bcl2l11
|
BCL2 like 11
|
increases expression
|
EXP
|
lead acetate results in increased expression of BCL2L11 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467
|
|
| G
|
Bcl6
|
B cell leukemia/lymphoma 6
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of BCL6 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602
|
|
| G
|
Bcl9l
|
B cell CLL/lymphoma 9-like
|
increases expression
|
ISO
|
lead acetate results in increased expression of BCL9L mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:44,394,103...44,423,203
Ensembl chr 9:44,394,122...44,423,193
|
|
| G
|
Bco2
|
beta-carotene oxygenase 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of BCO2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:50,444,387...50,466,513
Ensembl chr 9:50,444,387...50,466,481
|
|
| G
|
Bdh2
|
3-hydroxybutyrate dehydrogenase, type 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of BDH2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 3:134,986,982...135,010,187
Ensembl chr 3:134,986,982...135,010,187
|
|
| G
|
Bdkrb1
|
bradykinin receptor, beta 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of BDKRB1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687
|
|
| G
|
Bdnf
|
brain derived neurotrophic factor
|
increases expression multiple interactions affects expression decreases expression decreases secretion decreases response to substance
|
ISO EXP
|
lead acetate results in increased expression of BDNF mRNA 3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in decreased expression of BDNF protein]; [lead acetate results in increased abundance of Lead] which results in decreased expression of BDNF protein [lead acetate results in increased abundance of Lead] which results in decreased cleavage of BDNF protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of BDNF mRNA; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of BDNF protein; BDNF protein inhibits the reaction [lead acetate results in decreased expression of SYP protein]; BDNF protein inhibits the reaction [lead acetate results in decreased expression of VAMP2 protein]; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased cleavage of BDNF protein]; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BDNF mRNA] lead acetate affects the expression of BDNF mRNA alternative form lead acetate results in decreased expression of BDNF mRNA alternative form; lead acetate results in decreased expression of BDNF protein lead acetate results in decreased expression of BDNF mRNA; lead acetate results in decreased expression of BDNF protein lead acetate results in decreased secretion of BDNF protein BDNF protein results in decreased susceptibility to lead acetate
|
CTD |
PMID:20375082 PMID:23146751 PMID:23680456 PMID:24260418 PMID:27492863 PMID:27984133 PMID:30523571 PMID:32058320 PMID:33862172 PMID:33978298 PMID:37385299 More...
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|
NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
|
|
| G
|
Becn1
|
beclin 1, autophagy related
|
increases cleavage multiple interactions increases expression
|
ISO
|
lead acetate results in increased cleavage of BECN1 protein [lead acetate results in increased abundance of Lead] which results in increased expression of BECN1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of BECN1 protein; bafilomycin A1 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BECN1 protein] lead acetate results in increased expression of BECN1 protein
|
CTD |
PMID:22811615 PMID:32879255 PMID:33242459 PMID:36652739 |
|
NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
|
|
| G
|
Best3
|
bestrophin 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of BEST3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr10:116,822,219...116,865,688
Ensembl chr10:116,822,219...116,860,945
|
|
| G
|
Bex4
|
brain expressed X-linked 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of BEX4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr X:135,039,745...135,041,192
Ensembl chr X:135,039,745...135,041,192
|
|
| G
|
Bglap
|
bone gamma carboxyglutamate protein
|
multiple interactions decreases expression
|
ISO
|
Ethanol promotes the reaction [lead acetate results in decreased expression of BGLAP protein]
|
CTD |
PMID:23376407 |
|
NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
|
|
| G
|
Bhmt
|
betaine-homocysteine methyltransferase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of BHMT mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469
|
|
| G
|
Bid
|
BH3 interacting domain death agonist
|
affects expression multiple interactions
|
ISO
|
lead acetate affects the expression of BID protein [lead acetate results in increased abundance of Lead] which results in increased expression of BID mRNA
|
CTD |
PMID:18618274 PMID:36642386 |
|
NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
|
|
| G
|
Birc3
|
baculoviral IAP repeat-containing 3
|
decreases expression
|
EXP ISO
|
lead acetate results in decreased expression of BIRC3 mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
|
|
| G
|
Birc5
|
baculoviral IAP repeat-containing 5
|
multiple interactions decreases expression
|
ISO
|
RBBP4 protein inhibits the reaction [lead acetate results in decreased expression of BIRC5 mRNA]; RBBP4 protein inhibits the reaction [lead acetate results in decreased expression of BIRC5 protein] lead acetate results in decreased expression of BIRC5 mRNA; lead acetate results in decreased expression of BIRC5 protein
|
CTD |
PMID:37866543 |
|
NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
|
|
| G
|
Bloc1s2
|
biogenesis of lysosomal organelles complex-1, subunit 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of BLOC1S2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr19:44,127,685...44,134,909
Ensembl chr19:44,127,685...44,134,885
|
|
| G
|
Blvrb
|
biliverdin reductase B
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of BLVRB mRNA
|
CTD |
PMID:25270620 PMID:38568856 |
|
NCBI chr 7:27,147,403...27,165,406
Ensembl chr 7:27,147,403...27,165,569
|
|
| G
|
Bmal1
|
basic helix-loop-helix ARNT like 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of BMAL1 mRNA
|
CTD |
PMID:36642386 |
|
NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333
|
|
| G
|
Bmp1
|
bone morphogenetic protein 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of BMP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:70,711,998...70,758,280
Ensembl chr14:70,711,998...70,757,674
|
|
| G
|
Bmp10
|
bone morphogenetic protein 10
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of BMP10 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 6:87,405,976...87,411,494
Ensembl chr 6:87,405,976...87,414,659
|
|
| G
|
Bmp2
|
bone morphogenetic protein 2
|
multiple interactions decreases expression increases expression increases activity
|
ISO EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of BMP2 mRNA lead acetate results in decreased expression of BMP2 mRNA lead acetate results in increased expression of BMP2 mRNA lead acetate results in increased activity of BMP2 protein BMP2 promotes the reaction [lead acetate results in increased expression of ACAN mRNA]; BMP2 promotes the reaction [lead acetate results in increased expression of COL2A1 mRNA]; BMP2 promotes the reaction [lead acetate results in increased expression of SOX9 mRNA]; lead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD1 protein]; lead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD5 protein]; lead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD9 protein]; lead acetate promotes the reaction [BMP2 results in increased expression of ACAN mRNA]; lead acetate promotes the reaction [BMP2 results in increased expression of SOX9 mRNA]
|
CTD |
PMID:12634122 PMID:17805416 PMID:21829687 PMID:22641619 |
|
NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805
|
|
| G
|
Bmp3
|
bone morphogenetic protein 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of BMP3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:99,002,274...99,031,912
Ensembl chr 5:99,002,274...99,032,255
|
|
| G
|
Bmp4
|
bone morphogenetic protein 4
|
multiple interactions decreases expression
|
ISO EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of BMP4 mRNA lead acetate results in decreased expression of BMP4 mRNA
|
CTD |
PMID:12634122 PMID:22613225 |
|
NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126
|
|
| G
|
Bnc2
|
basonuclin zinc finger protein 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of BNC2 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 4:84,185,041...84,593,236
Ensembl chr 4:84,193,332...84,593,512
|
|
| G
|
Bnip3
|
BCL2/adenovirus E1B interacting protein 3
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of BNIP3 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
|
|
| G
|
Bnip3l
|
BCL2/adenovirus E1B interacting protein 3-like
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of BNIP3L mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326
|
|
| G
|
Bpifb3
|
BPI fold containing family B, member 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of BPIFB3 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:153,760,118...153,774,916
Ensembl chr 2:153,760,150...153,774,916
|
|
| G
|
Brca1
|
breast cancer 1, early onset
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of BRCA1 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781
|
|
| G
|
Brd4
|
bromodomain containing 4
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of BRD4 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr17:32,415,246...32,503,717
Ensembl chr17:32,415,248...32,503,696
|
|
| G
|
Bri3
|
brain protein I3
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of BRI3 mRNA lead acetate results in increased expression of BRI3 mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr 5:144,181,247...144,383,567
Ensembl chr 5:144,181,247...144,383,567
|
|
| G
|
Bsg
|
basigin
|
affects expression multiple interactions
|
EXP
|
lead acetate affects the expression of BSG mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of BSG protein; [Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BSG protein]; lead acetate results in decreased expression of and affects the localization of BSG protein
|
CTD |
PMID:30615929 PMID:34508822 |
|
NCBI chr10:79,540,192...79,547,813
Ensembl chr10:79,540,325...79,547,803
|
|
| G
|
Bsx
|
brain specific homeobox
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of BSX mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:40,782,994...40,790,258
Ensembl chr 9:40,785,423...40,791,353
|
|
| G
|
Btbd1
|
BTB domain containing 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of BTBD1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:81,441,822...81,479,262
Ensembl chr 7:81,441,822...81,479,179
|
|
| G
|
Btbd7
|
BTB domain containing 7
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of BTBD7 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr12:102,747,056...102,844,733
Ensembl chr12:102,747,056...102,844,730
|
|
| G
|
Btbd9
|
BTB domain containing 9
|
increases expression
|
EXP
|
lead acetate results in increased expression of BTBD9 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr17:30,434,498...30,801,595
Ensembl chr17:30,434,498...30,795,462
|
|
| G
|
Btg2
|
BTG anti-proliferation factor 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of BTG2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858
|
|
| G
|
Btla
|
B and T lymphocyte associated
|
increases expression
|
EXP
|
lead acetate results in increased expression of BTLA mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr16:45,043,121...45,073,258
Ensembl chr16:45,044,678...45,078,033
|
|
| G
|
Btnl4
|
butyrophilin-like 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of BTNL4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr17:34,687,320...34,696,402
Ensembl chr17:34,685,536...34,696,292
|
|
| G
|
Bub1
|
BUB1, mitotic checkpoint serine/threonine kinase
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of BUB1 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785
|
|
| G
|
C2
|
complement C2
|
increases expression
|
EXP
|
lead acetate results in increased expression of C2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr17:35,081,578...35,101,076
Ensembl chr17:35,081,580...35,117,241
|
|
| G
|
C3
|
complement component 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of C3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
|
|
| G
|
C4bp
|
complement component 4 binding protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of C4BP mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:130,562,510...130,589,365
Ensembl chr 1:130,562,510...130,589,369
|
|
| G
|
C5ar1
|
complement component 5a receptor 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of C5AR1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465
|
|
| G
|
C77545
|
expressed sequence C77545
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of C77545 mRNA
|
CTD |
PMID:22609695 |
|
|
|
| G
|
C78859
|
expressed sequence C78859
|
increases expression
|
EXP
|
lead acetate results in increased expression of C78859 mRNA
|
CTD |
PMID:22609695 |
|
Ensembl chr 8:95,048,786...95,054,728
|
|
| G
|
C79242
|
expressed sequence C79242
|
increases expression
|
EXP
|
lead acetate results in increased expression of C79242 mRNA
|
CTD |
PMID:21829687 |
|
|
|
| G
|
C80719
|
expressed sequence C80719
|
increases expression
|
EXP
|
lead acetate results in increased expression of C80719 mRNA
|
CTD |
PMID:22609695 |
|
|
|
| G
|
C86400
|
expressed sequence C86400
|
increases expression
|
EXP
|
lead acetate results in increased expression of C86400 mRNA
|
CTD |
PMID:20542052 |
|
|
|
| G
|
C9
|
complement component 9
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of C9 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:6,474,827...6,528,306
Ensembl chr15:6,474,808...6,528,232
|
|
| G
|
Cables1
|
CDK5 and Abl enzyme substrate 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of CABLES1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr18:11,972,600...12,078,681
Ensembl chr18:11,972,277...12,078,687
|
|
| G
|
Cacna1b
|
calcium channel, voltage-dependent, N type, alpha 1B subunit
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CACNA1B mRNA
|
CTD |
PMID:33932463 |
|
NCBI chr 2:24,493,872...24,653,210
Ensembl chr 2:24,493,899...24,653,164
|
|
| G
|
Cacna1f
|
calcium channel, voltage-dependent, alpha 1F subunit
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CACNA1F mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr X:7,473,342...7,501,435
Ensembl chr X:7,473,322...7,501,435
|
|
| G
|
Cacna2d1
|
calcium channel, voltage-dependent, alpha2/delta subunit 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CACNA2D1 mRNA
|
CTD |
PMID:33932463 |
|
NCBI chr 5:16,139,390...16,579,509
Ensembl chr 5:16,139,786...16,579,502
|
|
| G
|
Cacna2d4
|
calcium channel, voltage-dependent, alpha 2/delta subunit 4
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decreases expression
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ISO
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lead acetate results in decreased expression of CACNA2D4 mRNA
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CTD |
PMID:22641619 |
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NCBI chr 6:119,213,435...119,329,368
Ensembl chr 6:119,213,487...119,329,368
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| G
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Cadm1
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cell adhesion molecule 1
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affects expression
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ISO
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lead acetate affects the expression of CADM1 protein
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CTD |
PMID:36539177 |
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NCBI chr 9:47,441,468...47,773,578
Ensembl chr 9:47,441,471...47,769,413
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| G
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Cadm3
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cell adhesion molecule 3
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decreases expression
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ISO
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lead acetate results in decreased expression of CADM3 mRNA
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CTD |
PMID:38568856 |
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NCBI chr 1:173,161,825...173,195,214
Ensembl chr 1:173,160,825...173,195,261
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| G
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Calb1
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calbindin 1
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increases expression
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ISO
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lead acetate results in increased expression of CALB1 mRNA
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CTD |
PMID:33862172 |
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NCBI chr 4:15,881,264...15,906,709
Ensembl chr 4:15,881,264...15,908,064
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| G
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Calb2
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calbindin 2
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multiple interactions
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ISO
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[lead acetate results in increased abundance of Lead] which results in decreased expression of CALB2 protein; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CALB2 protein]
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CTD |
PMID:31708536 |
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NCBI chr 8:110,869,158...110,894,844
Ensembl chr 8:110,864,134...110,894,842
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| G
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Calca
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calcitonin/calcitonin-related polypeptide, alpha
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decreases expression multiple interactions
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ISO
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lead acetate results in decreased expression of CALCA mRNA; lead acetate results in decreased expression of CALCA protein [Ethanol co-treated with lead acetate] results in increased expression of CALCA protein
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CTD |
PMID:22641619 PMID:23376407 |
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NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
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| G
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Cald1
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caldesmon 1
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decreases expression
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ISO
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lead acetate results in decreased expression of CALD1 mRNA
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CTD |
PMID:11578147 |
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NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408
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| G
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Calml3
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calmodulin-like 3
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increases expression
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ISO
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lead acetate results in increased expression of CALML3 mRNA
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CTD |
PMID:11578147 |
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NCBI chr13:3,852,893...3,854,318
Ensembl chr13:3,852,896...3,854,316
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| G
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Calr
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calreticulin
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decreases expression
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EXP
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lead acetate results in decreased expression of CALR mRNA
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CTD |
PMID:21829687 |
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NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563
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| G
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Calu
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calumenin
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increases expression
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EXP ISO
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lead acetate results in increased expression of CALU mRNA
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CTD |
PMID:20542052 PMID:38568856 |
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NCBI chr 6:29,348,105...29,376,674
Ensembl chr 6:29,348,068...29,377,109
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| G
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Camk2a
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calcium/calmodulin-dependent protein kinase II alpha
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decreases expression multiple interactions decreases phosphorylation
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ISO EXP
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lead acetate results in decreased expression of CAMK2A mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of and results in decreased phosphorylation of CAMK2A protein Quercetin inhibits the reaction [lead acetate results in decreased phosphorylation of CAMK2A protein]
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CTD |
PMID:22160880 PMID:23855546 PMID:30905827 |
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NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224
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| G
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Camk2b
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calcium/calmodulin-dependent protein kinase II, beta
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decreases expression
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ISO
|
lead acetate results in decreased expression of CAMK2B mRNA
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CTD |
PMID:38568856 |
|
NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362
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| G
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Camk2d
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calcium/calmodulin-dependent protein kinase II, delta
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decreases expression multiple interactions
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ISO
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lead acetate results in decreased expression of CAMK2D mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of CAMK2D mRNA
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CTD |
PMID:22641619 PMID:33080273 |
|
NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975
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| G
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Camk2n2
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calcium/calmodulin-dependent protein kinase II inhibitor 2
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decreases expression
|
EXP
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lead acetate results in decreased expression of CAMK2N2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr16:20,437,965...20,440,028
Ensembl chr16:20,437,965...20,440,037
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| G
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Camkk2
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calcium/calmodulin-dependent protein kinase kinase 2, beta
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multiple interactions
|
EXP
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[lead acetate results in increased abundance of Lead] which results in increased methylation of CAMKK2 intron
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CTD |
PMID:33445541 |
|
NCBI chr 5:122,856,064...122,918,295
Ensembl chr 5:122,869,233...122,917,472
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| G
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Cand1
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cullin associated and neddylation disassociated 1
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multiple interactions
|
ISO
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[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CAND1 mRNA
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CTD |
PMID:22839698 |
|
NCBI chr10:119,034,717...119,075,960
Ensembl chr10:119,035,160...119,075,960
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| G
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Capsl
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calcyphosine-like
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increases expression
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ISO
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lead acetate results in increased expression of CAPSL mRNA
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CTD |
PMID:22641619 |
|
NCBI chr15:9,436,136...9,466,125
Ensembl chr15:9,436,114...9,466,124
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| G
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Car11
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carbonic anhydrase 11
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increases expression
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EXP
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lead acetate results in increased expression of CAR11 mRNA
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CTD |
PMID:20542052 |
|
NCBI chr 7:45,348,537...45,354,106
Ensembl chr 7:45,349,267...45,354,106
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| G
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Car13
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carbonic anhydrase 13
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affects expression
|
ISO
|
lead acetate affects the expression of CAR13 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:14,706,787...14,728,062
Ensembl chr 3:14,706,787...14,728,062
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| G
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Car14
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carbonic anhydrase 14
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affects expression
|
ISO
|
lead acetate affects the expression of CAR14 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 3:95,805,080...95,812,443
Ensembl chr 3:95,805,080...95,812,003
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| G
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Car2
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carbonic anhydrase 2
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decreases expression
|
ISO
|
lead acetate results in decreased expression of CA2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830
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| G
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Car8
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carbonic anhydrase 8
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decreases expression
|
EXP
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lead acetate results in decreased expression of CAR8 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 4:8,141,491...8,239,226
Ensembl chr 4:8,143,362...8,239,041
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| G
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Car9
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carbonic anhydrase 9
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decreases expression
|
ISO
|
lead acetate results in decreased expression of CA9 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729
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| G
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Card14
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caspase recruitment domain family, member 14
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decreases expression
|
EXP
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lead acetate results in decreased expression of CARD14 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:119,197,923...119,236,205
Ensembl chr11:119,198,594...119,236,201
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|
| G
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Carhsp1
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calcium regulated heat stable protein 1
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affects expression
|
ISO
|
lead acetate affects the expression of CARHSP1 protein
|
CTD |
PMID:36539177 |
|
NCBI chr16:8,476,444...8,490,017
Ensembl chr16:8,476,444...8,490,019
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|
| G
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Cars1
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cysteinyl-tRNA synthetase 1
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increases expression
|
ISO
|
lead acetate results in increased expression of CARS1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 7:143,110,967...143,153,827
Ensembl chr 7:143,110,967...143,153,827
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| G
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Casp1
|
caspase 1
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increases expression multiple interactions
|
EXP
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lead acetate results in increased expression of CASP1 mRNA 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP1 protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased cleavage of CASP1 protein; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased cleavage of CASP1 protein]
|
CTD |
PMID:22609695 PMID:36308466 |
|
NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
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|
| G
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Casp3
|
caspase 3
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increases activity increases expression increases cleavage multiple interactions affects expression decreases expression
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ISO EXP
|
lead acetate results in increased activity of CASP3 protein lead acetate results in increased expression of CASP3 mRNA; lead acetate results in increased expression of CASP3 protein lead acetate results in increased cleavage of CASP3 protein [[amyloid beta-protein (1-40) co-treated with amyloid beta-protein (25-35)] co-treated with [lead acetate results in increased abundance of Lead]] results in increased cleavage of CASP3 protein; [lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP3 protein; HMOX1 protein affects the reaction [lead acetate affects the expression of CASP3 protein]; NFE2L2 protein inhibits the reaction [lead acetate results in increased activity of CASP3 protein] 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in increased expression of CASP3 protein]; [Cadmium Chloride co-treated with lead acetate] results in increased expression of CASP3 protein; [lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP3 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of CASP3 protein; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased expression of CASP3 protein modified form; Biological Factors inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; Biological Factors inhibits the reaction [lead acetate results in increased expression of CASP3 protein]; Carbenoxolone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; Genistein inhibits the reaction [lead acetate results in increased cleavage of CASP3 protein]; lead acetate promotes the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate promotes the reaction [sodium arsenite results in increased expression of CASP3 mRNA]]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite promotes the reaction [lead acetate results in increased expression of CASP3 mRNA]]; Plant Oils inhibits the reaction [lead acetate results in increased expression of CASP3 protein]; Plant Preparations inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; Plant Preparations inhibits the reaction [lead acetate results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of CASP3 protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of CASP3 mRNA]; sodium arsenite promotes the reaction [lead acetate results in increased expression of CASP3 mRNA]; sodium bisulfide inhibits the reaction [lead acetate results in increased expression of CASP3 protein]; sodium boranocarbonate inhibits the reaction [lead acetate results in increased expression of CASP3 protein] lead acetate results in increased expression of CASP3 protein; lead acetate results in increased expression of CASP3 protein modified form [cupric chloride results in increased abundance of Copper] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased cleavage of CASP3 protein]; [lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP3 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased cleavage of CASP3 protein; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[cupric chloride results in increased abundance of Copper] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased cleavage of CASP3 protein]]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; MIR671 mRNA inhibits the reaction [lead acetate results in increased expression of CASP3 protein]; mitoquinone inhibits the reaction [[cupric chloride results in increased abundance of Copper] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased cleavage of CASP3 protein]]; PPARGC1A protein inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of CASP3 protein] lead acetate results in decreased expression of CASP3 mRNA
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CTD |
PMID:19026729 PMID:21640820 PMID:22033380 PMID:23146751 PMID:23318731 PMID:23680456 PMID:23906897 PMID:25031709 PMID:26498409 PMID:26542248 PMID:26797587 PMID:27236077 PMID:27604105 PMID:30251767 PMID:30703413 PMID:30980911 PMID:32116774 PMID:32208856 PMID:33242459 PMID:33978298 PMID:35300571 PMID:37397918 PMID:37471654 PMID:38530053 PMID:40010429 More...
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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| G
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Casp8
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caspase 8
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multiple interactions increases activity
|
EXP
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1,3-dimethylthiourea inhibits the reaction [lead acetate results in increased activity of CASP8 protein]; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of CASP8 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of CASP8 protein]; Imipramine inhibits the reaction [lead acetate results in increased activity of CASP8 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of CASP8 protein]
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CTD |
PMID:22033380 |
|
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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| G
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Casp9
|
caspase 9
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increases expression multiple interactions increases activity
|
ISO EXP
|
lead acetate results in increased expression of CASP9 mRNA lead acetate results in increased expression of CASP9 protein [lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP9 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA; MIR671 mRNA inhibits the reaction [lead acetate results in increased expression of CASP9 protein]; PPARGC1A protein inhibits the reaction [lead acetate results in increased activity of CASP9 protein] [lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP9 protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein; Carbenoxolone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased cleavage of CASP9 protein]; IL1RN protein inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]; lead acetate promotes the reaction [sodium arsenite results in increased expression of CASP9 mRNA]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate promotes the reaction [sodium arsenite results in increased expression of CASP9 mRNA]]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate results in increased expression of CASP9 mRNA]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite promotes the reaction [lead acetate results in increased expression of CASP9 mRNA]]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]; sodium arsenite promotes the reaction [lead acetate results in increased expression of CASP9 mRNA]
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CTD |
PMID:23906897 PMID:26396915 PMID:27236077 PMID:27604105 PMID:33242459 PMID:37397918 More...
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NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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| G
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Cat
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catalase
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multiple interactions decreases expression increases expression affects activity decreases activity increases activity
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ISO EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA; [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CAT mRNA; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA] lead acetate results in decreased expression of CAT protein lead acetate results in increased expression of CAT mRNA lead acetate affects the activity of CAT protein lead acetate results in increased expression of CAT mRNA; lead acetate results in increased expression of CAT protein lead acetate results in decreased expression of CAT mRNA; lead acetate results in decreased expression of CAT protein lead acetate results in decreased activity of CAT protein [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of CAT protein; [lead acetate results in increased abundance of Lead] promotes the reaction [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] which results in decreased expression of CAT protein]; [lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of CAT protein; [Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT protein]; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in decreased activity of CAT protein]; Clotrimazole inhibits the reaction [lead acetate results in decreased activity of CAT protein]; Fatty Acids, Omega-3 inhibits the reaction [lead acetate results in decreased expression of CAT protein]; S-allylcysteine inhibits the reaction [lead acetate results in decreased activity of CAT protein] lead acetate results in increased activity of CAT protein 3-nitropropionic acid affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of CAT protein]]; 3-nitropropionic acid affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of CAT protein]; 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in decreased expression of CAT mRNA]; [cadmium acetate co-treated with lead acetate] results in increased activity of CAT protein; [lead acetate co-treated with Cadmium Chloride] results in decreased activity of CAT protein; [lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of CAT protein]; [lead acetate results in increased abundance of Lead] which affects the expression of CAT protein; [lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of CAT mRNA; [Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CAT protein]; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of CAT protein]]; Amitrole affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of CAT protein]; Biological Factors inhibits the reaction [lead acetate results in decreased activity of CAT protein]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of CDH1 mRNA]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of CDH1 protein]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ACTA2 mRNA]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of CDH2 protein]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of CHD2 mRNA]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of SNAI1 mRNA]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of SNAI1 protein]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of VIM mRNA]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of VIM protein]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ZEB1 mRNA]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ZEB1 protein]; Cholecalciferol inhibits the reaction [lead acetate results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of CAT mRNA]; epigallocatechin gallate inhibits the reaction [lead acetate results in decreased activity of CAT protein]; Genistein inhibits the reaction [lead acetate results in decreased expression of CAT protein]; lead acetate promotes the reaction [sodium arsenite results in decreased activity of CAT protein]; lead acetate results in decreased expression of and results in decreased activity of CAT protein; lead acetate results in increased expression of and results in decreased activity of CAT protein; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate promotes the reaction [sodium arsenite results in decreased activity of CAT protein]]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate results in decreased activity of CAT protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite promotes the reaction [lead acetate results in decreased activity of CAT protein]]; naringenin inhibits the reaction [lead acetate results in decreased activity of CAT protein]; Plant Oils inhibits the reaction [lead acetate affects the activity of CAT protein]; Plant Preparations inhibits the reaction [lead acetate results in decreased activity of CAT protein]; Silybin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; sinapinic acid inhibits the reaction [lead acetate results in decreased activity of CAT protein]; sinapinic acid inhibits the reaction [lead acetate results in decreased expression of CAT protein]; sodium arsenite promotes the reaction [lead acetate results in decreased activity of CAT protein]
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CTD |
PMID:12634122 PMID:15569323 PMID:16897041 PMID:19347332 PMID:22033380 PMID:22197700 PMID:22534743 PMID:23906897 PMID:24184865 PMID:24222729 PMID:24970117 PMID:25800560 PMID:26797587 PMID:30251767 PMID:30510688 PMID:30623991 PMID:30703413 PMID:31054310 PMID:31550440 PMID:31610155 PMID:32116774 PMID:32208856 PMID:33862172 PMID:34051273 PMID:35307918 PMID:35527006 PMID:35752206 PMID:36807407 PMID:37397918 PMID:37471654 PMID:38180308 PMID:38530053 PMID:39722890 More...
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NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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| G
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Cav1
|
caveolin 1, caveolae protein
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of CAV1 mRNA lead acetate results in increased expression of CAV1 mRNA
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CTD |
PMID:11578147 PMID:22641619 |
|
NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451
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|
| G
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Cavin2
|
caveolae associated 2
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decreases expression
|
ISO
|
lead acetate results in decreased expression of CAVIN2 mRNA
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CTD |
PMID:38568856 |
|
NCBI chr 1:51,328,285...51,342,119
Ensembl chr 1:51,328,285...51,342,119
|
|
| G
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Cbl
|
Casitas B-lineage lymphoma
|
multiple interactions increases phosphorylation
|
ISO
|
CBL protein affects the reaction [lead acetate results in decreased expression of PDGFRA protein] lead acetate results in increased phosphorylation of CBL protein
|
CTD |
PMID:17298174 |
|
NCBI chr 9:44,054,273...44,145,556
Ensembl chr 9:44,054,273...44,145,346
|
|
| G
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Cblb
|
Casitas B-lineage lymphoma b
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CBLB mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411
|
|
| G
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Cbr1
|
carbonyl reductase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of CBR1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393
|
|
| G
|
Cbs
|
cystathionine beta-synthase
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of CBS mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212
|
|
| G
|
Cbx1
|
chromobox 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CBX1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:96,679,506...96,699,808
Ensembl chr11:96,679,953...96,699,466
|
|
| G
|
Cbx4
|
chromobox 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of CBX4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:118,968,399...118,977,067
Ensembl chr11:118,968,399...118,977,047
|
|
| G
|
Cbx6
|
chromobox 6
|
increases expression
|
ISO
|
lead acetate results in increased expression of CBX6 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:79,708,099...79,718,534
Ensembl chr15:79,708,097...79,718,889
|
|
| G
|
Cbx7
|
chromobox 7
|
increases expression
|
EXP
|
lead acetate results in increased expression of CBX7 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr15:79,800,005...79,855,344
Ensembl chr15:79,800,008...79,855,320
|
|
| G
|
Ccdc117
|
coiled-coil domain containing 117
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CCDC117 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:5,478,887...5,492,217
Ensembl chr11:5,478,887...5,492,187
|
|
| G
|
Ccdc18
|
coiled-coil domain containing 18
|
increases expression
|
EXP
|
lead acetate results in increased expression of CCDC18 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 5:108,280,583...108,388,378
Ensembl chr 5:108,280,741...108,381,494
|
|
| G
|
Ccdc22
|
coiled-coil domain containing 22
|
increases expression
|
ISO
|
lead acetate results in increased expression of CCDC22 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr X:7,460,048...7,471,659
Ensembl chr X:7,460,048...7,471,756
|
|
| G
|
Ccdc6
|
coiled-coil domain containing 6
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of CCDC6 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr10:69,932,709...70,029,030
Ensembl chr10:69,932,951...70,029,030
|
|
| G
|
Ccdc69
|
coiled-coil domain containing 69
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CCDC69 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:54,940,559...54,969,608
Ensembl chr11:54,940,557...54,968,957
|
|
| G
|
Ccdc71l
|
coiled-coil domain containing 71 like
|
increases expression
|
ISO
|
lead acetate results in increased expression of CCDC71L mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:32,428,788...32,432,942
Ensembl chr12:32,428,703...32,432,942
|
|
| G
|
Ccdc80
|
coiled-coil domain containing 80
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of CCDC80 mRNA lead acetate results in increased expression of CCDC80 mRNA
|
CTD |
PMID:20542052 PMID:38568856 |
|
NCBI chr16:44,913,770...44,948,287
Ensembl chr16:44,913,765...44,948,440
|
|
| G
|
Cckar
|
cholecystokinin A receptor
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CCKAR mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 5:53,855,827...53,865,046
Ensembl chr 5:53,855,118...53,865,047
|
|
| G
|
Ccl1
|
C-C motif chemokine ligand 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of CCL1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:82,067,492...82,070,638
Ensembl chr11:82,067,483...82,196,516
|
|
| G
|
Ccl12
|
C-C motif chemokine ligand 12
|
increases expression
|
EXP
|
lead acetate results in increased expression of CCL12 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:81,992,671...81,994,225
Ensembl chr11:81,992,671...81,994,226
|
|
| G
|
Ccl2
|
C-C motif chemokine ligand 2
|
decreases expression increases secretion multiple interactions
|
EXP
|
lead acetate results in decreased expression of CCL2 mRNA lead acetate results in increased secretion of CCL2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]; Celecoxib inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]; U 0126 inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]
|
CTD |
PMID:21829687 PMID:24530660 |
|
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
|
|
| G
|
Ccl20
|
C-C motif chemokine ligand 20
|
increases expression
|
ISO
|
lead acetate results in increased expression of CCL20 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
|
|
| G
|
Ccl26
|
C-C motif chemokine ligand 26
|
increases expression
|
ISO
|
lead acetate results in increased expression of CCL26 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:135,589,302...135,592,423
Ensembl chr 5:135,589,302...135,592,423
|
|
| G
|
Ccl28
|
C-C motif chemokine ligand 28
|
increases expression multiple interactions
|
EXP
|
lead acetate results in increased expression of CCL28 mRNA [lead acetate results in increased abundance of Lead] which results in increased methylation of CCL28 intron
|
CTD |
PMID:22609695 PMID:33445541 |
|
NCBI chr13:120,085,355...120,115,895
Ensembl chr13:120,085,355...120,115,895
|
|
| G
|
Ccl3
|
C-C motif chemokine ligand 3
|
multiple interactions
|
ISO
|
lead acetate promotes the reaction [Hemagglutinins results in increased secretion of CCL3 protein]
|
CTD |
PMID:22839698 |
|
NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181
|
|
| G
|
Ccl5
|
C-C motif chemokine ligand 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of CCL5 mRNA
|
CTD |
PMID:29746905 |
|
NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
|
|
| G
|
Ccn1
|
cellular communication network factor 1
|
affects expression increases expression
|
ISO
|
lead acetate affects the expression of CCN1 mRNA lead acetate results in increased expression of CCN1 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736
|
|
| G
|
Ccn2
|
cellular communication network factor 2
|
increases expression decreases expression
|
ISO EXP
|
lead acetate results in increased expression of CCN2 mRNA lead acetate results in decreased expression of CCN2 mRNA
|
CTD |
PMID:25270620 PMID:38568856 |
|
NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
|
|
| G
|
Ccnd1
|
cyclin D1
|
multiple interactions increases expression decreases expression
|
ISO EXP
|
APEX1 protein promotes the reaction [lead acetate results in increased expression of CCND1 protein]; E 3330 inhibits the reaction [lead acetate results in increased expression of CCND1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of CCND1 protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of CCND1 protein; Wortmannin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of CCND1 protein] lead acetate results in increased expression of CCND1 mRNA lead acetate results in decreased expression of CCND1 mRNA lead acetate results in increased expression of CCND1 mRNA; lead acetate results in increased expression of CCND1 protein
|
CTD |
PMID:18353414 PMID:23370007 PMID:25270620 PMID:33862172 PMID:38568856 |
|
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
|
|
| G
|
Ccne1
|
cyclin E1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CCNE1 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
|
|
| G
|
Ccnl2
|
cyclin L2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CCNL2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:155,894,468...155,909,005
Ensembl chr 4:155,896,946...155,909,000
|
|
| G
|
Ccr2
|
C-C motif chemokine receptor 2
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of CCR2 mRNA
|
CTD |
PMID:22609695 PMID:22641619 |
|
NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594
|
|
| G
|
Ccr4
|
C-C motif chemokine receptor 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of CCR4 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984 Ensembl chr 9:114,319,384...114,333,984
|
|
| G
|
Ccr7
|
C-C motif chemokine receptor 7
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CCR7 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:99,035,025...99,045,903
Ensembl chr11:99,035,022...99,045,903
|
|
| G
|
Ccr8
|
C-C motif chemokine receptor 8
|
increases expression
|
EXP
|
lead acetate results in increased expression of CCR8 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:119,921,199...119,923,972
Ensembl chr 9:119,921,180...119,923,972
|
|
| G
|
Ccs
|
copper chaperone for superoxide dismutase
|
increases expression
|
EXP
|
lead acetate results in increased expression of CCS mRNA
|
CTD |
PMID:29746905 |
|
NCBI chr19:4,875,394...4,889,326
Ensembl chr19:4,875,394...4,889,360
|
|
| G
|
Cd14
|
CD14 antigen
|
decreases expression multiple interactions
|
EXP ISO
|
lead acetate results in decreased expression of CD14 mRNA pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in decreased expression of CD14 mRNA]
|
CTD |
PMID:36539177 |
|
NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851
|
|
| G
|
Cd163
|
CD163 antigen
|
increases expression
|
ISO
|
lead acetate results in increased expression of CD163 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:124,281,596...124,307,488
Ensembl chr 6:124,281,615...124,307,486
|
|
| G
|
Cd209f
|
CD209f antigen
|
increases expression
|
EXP
|
lead acetate results in increased expression of CD209F mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 8:4,152,784...4,155,838
Ensembl chr 8:4,152,787...4,155,835
|
|
| G
|
Cd247
|
CD247 antigen
|
increases expression
|
EXP
|
lead acetate results in increased expression of CD247 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:165,607,514...165,698,722
Ensembl chr 1:165,616,250...165,704,846
|
|
| G
|
Cd27
|
CD27 antigen
|
increases expression decreases expression
|
EXP
|
lead acetate results in increased expression of CD27 mRNA lead acetate results in decreased expression of CD27 mRNA
|
CTD |
PMID:20542052 PMID:21829687 |
|
NCBI chr 6:125,209,583...125,214,014
Ensembl chr 6:125,209,585...125,213,973
|
|
| G
|
Cd300c2
|
CD300C molecule 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of CD300C2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:114,887,595...114,892,706
Ensembl chr11:114,887,547...114,895,058
|
|
| G
|
Cd36
|
CD36 molecule
|
increases expression
|
EXP
|
lead acetate results in increased expression of CD36 mRNA
|
CTD |
PMID:30623991 |
|
NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
|
|
| G
|
Cd3e
|
CD3 antigen, epsilon polypeptide
|
increases expression increases methylation
|
ISO
|
lead acetate results in increased expression of CD3E mRNA lead acetate results in increased methylation of CD3E gene
|
CTD |
PMID:22641619 PMID:29571894 |
|
NCBI chr 9:44,910,033...44,920,961
Ensembl chr 9:44,910,038...44,920,925
|
|
| G
|
Cd40
|
CD40 antigen
|
multiple interactions
|
EXP
|
[Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD40 protein
|
CTD |
PMID:17512567 |
|
NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
|
|
| G
|
Cd44
|
CD44 antigen
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of CD44 mRNA
|
CTD |
PMID:36642386 |
|
NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
|
|
| G
|
Cd47
|
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CD47 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr16:49,671,691...49,732,799
Ensembl chr16:49,620,896...49,735,373
|
|
| G
|
Cd48
|
CD48 antigen
|
increases expression
|
ISO
|
lead acetate results in increased expression of CD48 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:171,508,989...171,532,825
Ensembl chr 1:171,509,577...171,532,826
|
|
| G
|
Cd59b
|
CD59b antigen
|
increases mutagenesis
|
ISO
|
lead acetate results in increased mutagenesis of CD59 protein
|
CTD |
PMID:17045307 |
|
NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534
|
|
| G
|
Cd63
|
CD63 antigen
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of CD63 protein
|
CTD |
PMID:36840722 |
|
NCBI chr10:128,731,577...128,748,691
Ensembl chr10:128,736,858...128,748,691
|
|
| G
|
Cd68
|
CD68 antigen
|
increases expression
|
EXP
|
lead acetate results in increased expression of CD68 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979
|
|
| G
|
Cd70
|
CD70 antigen
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CD70 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:57,452,997...57,456,777
Ensembl chr17:57,452,997...57,456,777
|
|
| G
|
Cd79a
|
CD79A antigen (immunoglobulin-associated alpha)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CD79A mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:24,596,922...24,601,283
Ensembl chr 7:24,596,806...24,601,622
|
|
| G
|
Cd80
|
CD80 antigen
|
multiple interactions
|
EXP
|
[Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD80 protein
|
CTD |
PMID:17512567 |
|
NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
|
|
| G
|
Cd86
|
CD86 antigen
|
multiple interactions
|
EXP
|
[Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD86 protein
|
CTD |
PMID:17512567 |
|
NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
|
|
| G
|
Cd93
|
CD93 antigen
|
decreases expression
|
ISO EXP
|
lead acetate results in decreased expression of CD93 mRNA
|
CTD |
PMID:22613225 PMID:22641619 |
|
NCBI chr 2:148,278,571...148,285,455
Ensembl chr 2:148,278,560...148,285,483
|
|
| G
|
Cd99
|
CD99 antigen
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CD99 mRNA
|
CTD |
PMID:21829687 |
|
|
|
| G
|
Cdc42ep5
|
CDC42 effector protein 5
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CDC42EP5 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:4,154,259...4,167,830
Ensembl chr 7:4,154,259...4,167,859
|
|
| G
|
Cdc45
|
cell division cycle 45
|
increases expression
|
EXP
|
lead acetate results in increased expression of CDC45 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr16:18,599,202...18,632,371
Ensembl chr16:18,599,197...18,630,737
|
|
| G
|
Cdc6
|
cell division cycle 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CDC6 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766
|
|
| G
|
Cdca8
|
cell division cycle associated 8
|
increases expression
|
EXP
|
lead acetate results in increased expression of CDCA8 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:124,812,258...124,830,710
Ensembl chr 4:124,812,258...124,833,104
|
|
| G
|
Cdh1
|
cadherin 1
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of CDH1 mRNA [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of CDH1 protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of CDH1 protein; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of CDH1 mRNA]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of CDH1 protein]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of CDH1 mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of CDH1 protein]
|
CTD |
PMID:38568856 PMID:39722890 |
|
NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
|
|
| G
|
Cdh11
|
cadherin 11
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CDH11 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 8:103,358,727...103,512,125
Ensembl chr 8:103,358,727...103,512,274
|
|
| G
|
Cdh13
|
cadherin 13
|
affects expression
|
ISO
|
lead acetate affects the expression of CDH13 protein
|
CTD |
PMID:36539177 |
|
NCBI chr 8:119,010,150...120,051,668
Ensembl chr 8:119,010,472...120,051,660
|
|
| G
|
Cdh17
|
cadherin 17
|
increases expression
|
EXP
|
lead acetate results in increased expression of CDH17 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:11,758,157...11,817,905
Ensembl chr 4:11,758,147...11,817,895
|
|
| G
|
Cdh19
|
cadherin 19, type 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CDH19 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:110,811,802...110,905,331
Ensembl chr 1:110,816,056...110,905,314
|
|
| G
|
Cdh2
|
cadherin 2
|
multiple interactions
|
ISO
|
CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of CDH2 protein]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of CDH2 protein]
|
CTD |
PMID:39722890 |
|
NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303
|
|
| G
|
Cdh3
|
cadherin 3
|
affects expression decreases expression
|
ISO
|
lead acetate affects the expression of CDH3 mRNA lead acetate results in decreased expression of CDH3 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr 8:107,237,484...107,283,543
Ensembl chr 8:107,237,523...107,283,929
|
|
| G
|
Cdh7
|
cadherin 7, type 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CDH7 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:109,909,967...110,073,002
Ensembl chr 1:109,910,161...110,067,887
|
|
| G
|
Cdk1
|
cyclin dependent kinase 1
|
increases methylation decreases expression
|
ISO
|
lead acetate results in increased methylation of CDK1 gene lead acetate results in decreased expression of CDK1 mRNA
|
CTD |
PMID:29571894 PMID:33862172 |
|
NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
|
|
| G
|
Cdk13
|
cyclin dependent kinase 13
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CDK13 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr13:17,885,309...17,979,960
Ensembl chr13:17,884,900...17,979,682
|
|
| G
|
Cdk18
|
cyclin dependent kinase 18
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CDK18 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:132,041,285...132,067,433
Ensembl chr 1:132,039,975...132,067,422
|
|
| G
|
Cdk4
|
cyclin dependent kinase 4
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of CDK4 protein
|
CTD |
PMID:38072110 |
|
NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
|
|
| G
|
Cdk5
|
cyclin dependent kinase 5
|
multiple interactions increases expression increases cleavage
|
ISO EXP
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] promotes the reaction [CDK5 protein results in increased phosphorylation of PPARG protein]; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of and results in increased activity of CDK5 protein; pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein] lead acetate results in increased expression of CDK5 mRNA; lead acetate results in increased expression of CDK5 protein lead acetate results in increased cleavage of CDK5 protein
|
CTD |
PMID:24481447 PMID:24954411 PMID:27012722 PMID:27293183 |
|
NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528
|
|
| G
|
Cdk5r1
|
cyclin dependent kinase 5, regulatory subunit 1
|
multiple interactions
|
EXP
|
lead acetate affects the reaction [MAPT protein affects the abundance of CDK5R1 protein modified form]; lead acetate results in decreased expression of and results in increased cleavage of CDK5R1 protein
|
CTD |
PMID:24954411 PMID:29203278 |
|
NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010
|
|
| G
|
Cdk5rap3
|
CDK5 regulatory subunit associated protein 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CDK5RAP3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:96,798,251...96,807,359
Ensembl chr11:96,798,252...96,807,322
|
|
| G
|
Cdkal1
|
CDK5 regulatory subunit associated protein 1-like 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of CDKAL1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr13:29,375,729...30,039,665
Ensembl chr13:29,375,729...30,039,657
|
|
| G
|
Cdkl4
|
cyclin dependent kinase like 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of CDKL4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr17:80,830,979...80,885,242
Ensembl chr17:80,830,979...80,885,242
|
|
| G
|
Cdkn1a
|
cyclin dependent kinase inhibitor 1A
|
multiple interactions increases expression
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CDKN1A mRNA lead acetate results in increased expression of CDKN1A mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of CDKN1A protein; [lead acetate results in increased abundance of Lead] which results in increased expression of CDKN1A mRNA
|
CTD |
PMID:12634122 PMID:22641619 PMID:34350654 PMID:38568856 PMID:39276841 |
|
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
|
|
| G
|
Cdkn1c
|
cyclin dependent kinase inhibitor 1C
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CDKN1C mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787
|
|
| G
|
Cdkn2a
|
cyclin dependent kinase inhibitor 2A
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of CDKN2A mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
|
|
| G
|
Cdkn2b
|
cyclin dependent kinase inhibitor 2B
|
increases expression
|
ISO
|
lead acetate results in increased expression of CDKN2B mRNA
|
CTD |
PMID:33862172 PMID:37939567 |
|
NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276
|
|
| G
|
Cdkn2c
|
cyclin dependent kinase inhibitor 2C
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CDKN2C mRNA
|
CTD |
PMID:33862172 |
|
NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386
|
|
| G
|
Cdkn3
|
cyclin dependent kinase inhibitor 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of CDKN3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126
|
|
| G
|
Cdon
|
cell adhesion molecule-related/down-regulated by oncogenes
|
increases expression
|
EXP
|
lead acetate results in increased expression of CDON mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:35,332,836...35,418,948
Ensembl chr 9:35,332,424...35,418,948
|
|
| G
|
Cdr2
|
cerebellar degeneration-related 2
|
affects expression
|
ISO
|
lead acetate affects the expression of CDR2 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 7:120,556,259...120,581,535
Ensembl chr 7:120,556,259...120,581,535
|
|
| G
|
Cds2
|
CDP-diacylglycerol synthase 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of CDS2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:132,105,068...132,153,970
Ensembl chr 2:132,105,068...132,153,970
|
|
| G
|
Ceacam1
|
CEA cell adhesion molecule 1
|
increases expression increases methylation decreases expression
|
EXP ISO
|
lead acetate results in increased expression of CEACAM1 mRNA lead acetate results in increased methylation of CEACAM1 gene lead acetate results in decreased expression of CEACAM1 mRNA
|
CTD |
PMID:22609695 PMID:22641619 PMID:29571894 |
|
NCBI chr 7:25,161,127...25,177,072
Ensembl chr 7:25,161,132...25,177,028
|
|
| G
|
Ceacam10
|
CEA cell adhesion molecule 10
|
increases expression
|
ISO
|
lead acetate results in increased expression of CEACAM10 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:24,476,592...24,484,081
Ensembl chr 7:24,476,631...24,484,082
|
|
| G
|
Ceacam11
|
CEA cell adhesion molecule 11
|
increases expression
|
EXP
|
lead acetate results in increased expression of CEACAM11 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:17,706,092...17,712,481
Ensembl chr 7:17,706,049...17,712,481
|
|
| G
|
Cebpa
|
CCAAT/enhancer binding protein alpha
|
increases expression increases methylation decreases expression
|
EXP ISO
|
lead acetate results in increased expression of CEBPA mRNA lead acetate results in increased methylation of CEBPA gene lead acetate results in decreased expression of CEBPA mRNA
|
CTD |
PMID:20542052 PMID:21829687 PMID:29571894 |
|
NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
|
|
| G
|
Cebpb
|
CCAAT/enhancer binding protein beta
|
affects expression increases expression
|
EXP ISO
|
lead acetate affects the expression of CEBPB mRNA lead acetate results in increased expression of CEBPB mRNA
|
CTD |
PMID:21829687 PMID:25270620 PMID:38568856 |
|
NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
|
|
| G
|
Cebpe
|
CCAAT/enhancer binding protein epsilon
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of CEBPE gene
|
CTD |
PMID:29571894 |
|
NCBI chr14:54,947,823...54,949,604
Ensembl chr14:54,947,817...54,949,631
|
|
| G
|
Cel
|
carboxyl ester lipase
|
increases expression
|
EXP
|
lead acetate results in increased expression of CEL mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:28,445,831...28,453,415
Ensembl chr 2:28,445,807...28,453,415
|
|
| G
|
Cela3b
|
chymotrypsin-like elastase family, member 3B
|
increases expression
|
EXP
|
lead acetate results in increased expression of CELA3B mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 4:137,148,319...137,157,831
Ensembl chr 4:137,148,310...137,157,851
|
|
| G
|
Cemip2
|
cell migration inducing hyaluronidase 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CEMIP2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr19:21,755,704...21,835,724
Ensembl chr19:21,755,706...21,835,724
|
|
| G
|
Cend1
|
cell cycle exit and neuronal differentiation 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of CEND1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:141,006,359...141,009,475
Ensembl chr 7:141,006,359...141,009,404
|
|
| G
|
Cenpe
|
centromere protein E
|
increases expression
|
ISO
|
lead acetate results in increased expression of CENPE mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 3:134,918,324...134,979,301
Ensembl chr 3:134,918,298...134,979,372
|
|
| G
|
Cenpk
|
centromere protein K
|
increases expression
|
ISO
|
lead acetate results in increased expression of CENPK mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr13:104,365,474...104,386,130
Ensembl chr13:104,365,119...104,388,900
|
|
| G
|
Cenpo
|
centromere protein O
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CENPO mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr12:4,243,548...4,284,255
Ensembl chr12:4,246,004...4,284,294
|
|
| G
|
Cenpv
|
centromere protein V
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CENPV mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:62,415,770...62,430,695
Ensembl chr11:62,415,772...62,430,087
|
|
| G
|
Cenpw
|
centromere protein W
|
increases expression
|
ISO
|
lead acetate results in increased expression of CENPW mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:30,072,005...30,076,599
Ensembl chr10:30,070,565...30,076,556
|
|
| G
|
Cep162
|
centrosomal protein 162
|
increases expression
|
ISO
|
lead acetate results in increased expression of CEP162 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:87,071,626...87,137,589
Ensembl chr 9:87,071,630...87,137,589
|
|
| G
|
Cept1
|
choline/ethanolaminephosphotransferase 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CEPT1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:106,409,576...106,455,118
Ensembl chr 3:106,409,576...106,455,118
|
|
| G
|
Cers4
|
ceramide synthase 4
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CERS4 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 8:4,542,863...4,579,603
Ensembl chr 8:4,543,026...4,581,680
|
|
| G
|
Ces1d
|
carboxylesterase 1D
|
increases expression
|
ISO
|
lead acetate results in increased expression of CES1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
|
|
| G
|
Ces4a
|
carboxylesterase 4A
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CES4A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:105,858,432...105,876,741
Ensembl chr 8:105,858,432...105,876,741
|
|
| G
|
Cfap126
|
cilia and flagella associated protein 126
|
affects expression
|
ISO
|
lead acetate affects the expression of CFAP126 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 1:170,941,326...170,954,525
Ensembl chr 1:170,941,487...170,954,536
|
|
| G
|
Cfap70
|
cilia and flagella associated protein 70
|
increases expression
|
ISO
|
lead acetate results in increased expression of CFAP70 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:20,444,258...20,502,332
Ensembl chr14:20,444,261...20,502,294
|
|
| G
|
Cfap77
|
cilia and flagella associated protein 77
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CFAP77 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:28,845,493...28,945,078
Ensembl chr 2:28,816,961...28,945,078
|
|
| G
|
Cfhr1
|
complement factor H-related 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CFHR1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 1:139,474,802...139,487,960
Ensembl chr 1:139,474,791...139,488,010
|
|
| G
|
Cfp
|
complement factor properdin
|
increases expression
|
EXP
|
lead acetate results in increased expression of CFP mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr X:20,791,693...20,797,794
Ensembl chr X:20,791,693...20,797,794
|
|
| G
|
Cga
|
glycoprotein hormones, alpha subunit
|
decreases activity multiple interactions
|
EXP
|
lead acetate results in decreased activity of CGA protein lead acetate inhibits the reaction [CGA protein results in increased abundance of Progesterone]
|
CTD |
PMID:11213355 PMID:12647776 |
|
NCBI chr 4:34,893,779...34,907,374
Ensembl chr 4:34,893,779...34,907,370
|
|
| G
|
Cgref1
|
cell growth regulator with EF hand domain 1
|
affects methylation decreases expression
|
ISO
|
lead acetate affects the methylation of CGREF1 gene lead acetate results in decreased expression of CGREF1 mRNA
|
CTD |
PMID:29571894 |
|
NCBI chr 5:31,090,487...31,102,771
Ensembl chr 5:31,090,487...31,102,935
|
|
| G
|
Chac1
|
ChaC, cation transport regulator 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of CHAC1 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr 2:119,181,723...119,184,807
Ensembl chr 2:119,181,710...119,184,862
|
|
| G
|
Chchd5
|
coiled-coil-helix-coiled-coil-helix domain containing 5
|
increases expression
|
ISO
|
lead acetate results in increased expression of CHCHD5 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:128,971,620...128,976,032
Ensembl chr 2:128,971,620...128,976,054
|
|
| G
|
Chd2
|
chromodomain helicase DNA binding protein 2
|
multiple interactions
|
ISO
|
CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of CHD2 mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of CHD2 mRNA]
|
CTD |
PMID:39722890 |
|
NCBI chr 7:73,076,400...73,191,494
Ensembl chr 7:73,076,386...73,191,578
|
|
| G
|
Chd3
|
chromodomain helicase DNA binding protein 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CHD3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:69,234,099...69,260,325
Ensembl chr11:69,234,099...69,260,232
|
|
| G
|
Chd7
|
chromodomain helicase DNA binding protein 7
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CHD7 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 4:8,690,345...8,868,449
Ensembl chr 4:8,690,406...8,867,659
|
|
| G
|
Chd8
|
chromodomain helicase DNA binding protein 8
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of CHD8 mRNA [sodium arsenite co-treated with lead acetate] results in decreased expression of CHD8 protein
|
CTD |
PMID:38072110 |
|
NCBI chr14:52,435,608...52,495,499
Ensembl chr14:52,435,608...52,495,237
|
|
| G
|
Chdh
|
choline dehydrogenase
|
increases expression
|
EXP
|
lead acetate results in increased expression of CHDH mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr14:29,730,957...29,762,423
Ensembl chr14:29,730,980...29,762,484
|
|
| G
|
Chek1
|
checkpoint kinase 1
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of CHEK1 mRNA
|
CTD |
PMID:22609695 PMID:33862172 |
|
NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361
|
|
| G
|
Chid1
|
chitinase domain containing 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of CHID1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:141,073,049...141,119,818
Ensembl chr 7:141,073,049...141,119,770
|
|
| G
|
Chmp5
|
charged multivesicular body protein 5
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of CHMP5 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr 4:40,948,553...40,965,302
Ensembl chr 4:40,948,407...40,965,303
|
|
| G
|
Chordc1
|
cysteine and histidine rich domain containing 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of CHORDC1 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 9:18,203,563...18,225,296
Ensembl chr 9:18,203,421...18,228,738
|
|
| G
|
Chpf
|
chondroitin polymerizing factor
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of CHPF protein
|
CTD |
PMID:38072110 |
|
NCBI chr 1:75,451,213...75,456,115
Ensembl chr 1:75,451,213...75,455,951
|
|
| G
|
Chrna7
|
cholinergic receptor, nicotinic, alpha polypeptide 7
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of CHRNA7 mRNA lead acetate results in increased expression of CHRNA7 mRNA
|
CTD |
PMID:33862172 |
|
NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317
|
|
| G
|
Chrnb2
|
cholinergic receptor nicotinic beta 2 subunit
|
increases expression
|
ISO
|
lead acetate results in increased expression of CHRNB2 mRNA
|
CTD |
PMID:33862172 |
|
NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939
|
|
| G
|
Chrnb4
|
cholinergic receptor, nicotinic, beta polypeptide 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CHRNB4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:54,935,438...54,956,236
Ensembl chr 9:54,935,438...54,956,063
|
|
| G
|
Chst11
|
carbohydrate sulfotransferase 11
|
increases expression
|
ISO
|
lead acetate results in increased expression of CHST11 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:82,820,274...83,031,738
Ensembl chr10:82,821,332...83,031,734
|
|
| G
|
Chuk
|
conserved helix-loop-helix ubiquitous kinase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CHUK protein
|
CTD |
PMID:16547843 |
|
NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
|
|
| G
|
Ciapin1
|
cytokine induced apoptosis inhibitor 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of CIAPIN1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 8:95,546,446...95,565,454
Ensembl chr 8:95,546,432...95,564,986
|
|
| G
|
Cimip6
|
ciliary microtubule inner protein 6
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CIMIP6 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:30,376,006...30,421,829
Ensembl chr11:30,376,006...30,421,827
|
|
| G
|
Cited2
|
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CITED2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422
|
|
| G
|
Ckap4
|
cytoskeleton-associated protein 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of CKAP4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:84,362,169...84,369,752
Ensembl chr10:84,362,169...84,369,926
|
|
| G
|
Ckb
|
creatine kinase, brain
|
multiple interactions increases expression
|
ISO EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKB mRNA Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]]; lead acetate results in increased secretion of [CKM protein binds to CKB protein] lead acetate results in increased expression of CKB protein
|
CTD |
PMID:12634122 PMID:20797405 PMID:21378372 |
|
NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772
|
|
| G
|
Cklf
|
chemokine-like factor
|
affects expression
|
EXP
|
lead acetate affects the expression of CKLF mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:104,977,493...104,992,642
Ensembl chr 8:104,977,493...104,991,570
|
|
| G
|
Ckm
|
creatine kinase, muscle
|
increases expression decreases expression multiple interactions
|
ISO EXP
|
lead acetate results in increased expression of CKM mRNA lead acetate results in decreased expression of CKM mRNA; lead acetate results in decreased expression of CKM protein HDAC2 protein promotes the reaction [lead acetate results in decreased expression of CKM mRNA]; HDAC2 protein promotes the reaction [lead acetate results in decreased expression of CKM protein] Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]]; lead acetate results in increased secretion of [CKM protein binds to CKB protein] [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CKM mRNA
|
CTD |
PMID:11578147 PMID:12634122 PMID:21378372 PMID:37797690 |
|
NCBI chr 7:19,145,019...19,155,508
Ensembl chr 7:19,138,701...19,156,766
|
|
| G
|
Clca2
|
chloride channel accessory 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CLCA2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:144,776,021...144,805,204
Ensembl chr 3:144,776,024...144,805,204
|
|
| G
|
Clcf1
|
cardiotrophin-like cytokine factor 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of CLCF1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:4,264,479...4,273,548
Ensembl chr19:4,264,292...4,273,544
|
|
| G
|
Clcn3
|
chloride channel, voltage-sensitive 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of CLCN3 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 8:61,363,423...61,436,351
Ensembl chr 8:61,363,423...61,436,334
|
|
| G
|
Clcn7
|
chloride channel, voltage-sensitive 7
|
increases expression
|
ISO
|
lead acetate results in increased expression of CLCN7 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr17:25,352,353...25,381,077
Ensembl chr17:25,352,365...25,381,078
|
|
| G
|
Cldn1
|
claudin 1
|
affects expression
|
ISO
|
lead acetate affects the expression of CLDN1 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591
|
|
| G
|
Cldn11
|
claudin 11
|
affects expression
|
ISO
|
lead acetate affects the expression of CLDN11 protein
|
CTD |
PMID:36539177 |
|
NCBI chr 3:31,204,069...31,218,475
Ensembl chr 3:31,204,069...31,218,473
|
|
| G
|
Cldn19
|
claudin 19
|
affects expression
|
ISO
|
lead acetate affects the expression of CLDN19 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 4:119,112,638...119,119,635
Ensembl chr 4:119,112,611...119,119,635
|
|
| G
|
Cldn23
|
claudin 23
|
increases expression
|
EXP
|
lead acetate results in increased expression of CLDN23 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:36,291,863...36,293,713
Ensembl chr 8:36,291,866...36,293,713
|
|
| G
|
Cldn5
|
claudin 5
|
multiple interactions decreases expression
|
EXP ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of CLDN5 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of CLDN5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of CLDN5 protein]
|
CTD |
PMID:24200059 PMID:31730887 |
|
NCBI chr16:18,595,597...18,597,012
Ensembl chr16:18,595,597...18,597,012
|
|
| G
|
Cldn7
|
claudin 7
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CLDN7 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:69,855,605...69,858,712
Ensembl chr11:69,855,605...69,858,711
|
|
| G
|
Clec2g
|
C-type lectin domain family 2, member g
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CLEC2G mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:128,911,344...128,961,670
Ensembl chr 6:128,911,344...128,961,670
|
|
| G
|
Clec3a
|
C-type lectin domain family 3, member a
|
increases expression
|
ISO
|
lead acetate results in increased expression of CLEC3A mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 8:115,144,744...115,154,871
Ensembl chr 8:115,144,826...115,152,586
|
|
| G
|
Clec4n
|
C-type lectin domain family 4, member n
|
increases expression
|
EXP
|
lead acetate results in increased expression of CLEC4N mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 6:123,206,802...123,223,983
Ensembl chr 6:123,206,802...123,223,980
|
|
| G
|
Clgn
|
calmegin
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CLGN mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:84,116,454...84,155,181
Ensembl chr 8:84,116,496...84,155,181
|
|
| G
|
Clic6
|
chloride intracellular channel 6
|
affects expression
|
ISO
|
lead acetate affects the expression of CLIC6 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr16:92,295,035...92,338,129
Ensembl chr16:92,282,624...92,338,131
|
|
| G
|
Clip3
|
CAP-GLY domain containing linker protein 3
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of CLIP3 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 7:29,991,120...30,007,792
Ensembl chr 7:29,991,153...30,007,792
|
|
| G
|
Clpp
|
caseinolytic mitochondrial matrix peptidase proteolytic subunit
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of CLPP mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of CLPP protein; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of CLPP mRNA]
|
CTD |
PMID:39547369 |
|
NCBI chr17:57,297,264...57,303,371
Ensembl chr17:57,297,305...57,303,188
|
|
| G
|
Clspn
|
claspin
|
increases expression
|
ISO
|
lead acetate results in increased expression of CLSPN mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:126,450,738...126,488,326
Ensembl chr 4:126,450,728...126,487,696
|
|
| G
|
Clstn1
|
calsyntenin 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of CLSTN1 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 4:149,670,536...149,733,356
Ensembl chr 4:149,670,925...149,733,356
|
|
| G
|
Cltrn
|
collectrin, amino acid transport regulator
|
affects expression
|
ISO
|
lead acetate affects the expression of CLTRN mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr X:162,873,183...162,901,855
Ensembl chr X:162,871,826...162,901,856
|
|
| G
|
Clxn
|
calaxin
|
affects expression decreases expression
|
ISO
|
lead acetate affects the expression of CLXN mRNA lead acetate results in decreased expression of CLXN mRNA
|
CTD |
PMID:21864555 PMID:22641619 |
|
NCBI chr16:14,724,315...14,786,925
Ensembl chr16:14,724,470...14,799,235
|
|
| G
|
Clybl
|
citrate lyase beta like
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of CLYBL protein
|
CTD |
PMID:38072110 |
|
NCBI chr14:122,408,289...122,639,646
Ensembl chr14:122,419,116...122,639,646
|
|
| G
|
Cmbl
|
carboxymethylenebutenolidase homolog
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of CMBL mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr15:31,565,314...31,590,266
Ensembl chr15:31,565,535...31,590,265
|
|
| G
|
Cmc1
|
C-X9-C motif containing 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CMC1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:117,893,051...117,979,264
Ensembl chr 9:117,893,590...117,979,245
|
|
| G
|
Cndp2
|
CNDP dipeptidase 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of CNDP2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr18:84,685,590...84,703,827
Ensembl chr18:84,685,590...84,703,827
|
|
| G
|
Cngb3
|
cyclic nucleotide gated channel beta 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CNGB3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 4:19,280,850...19,510,623
Ensembl chr 4:19,280,850...19,510,623
|
|
| G
|
Cnmd
|
chondromodulin
|
affects expression
|
ISO
|
lead acetate affects the expression of CNMD mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:79,875,126...79,899,596
Ensembl chr14:79,875,130...79,899,610
|
|
| G
|
Cnnm3
|
cyclin M3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CNNM3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:36,550,948...36,567,318
Ensembl chr 1:36,550,948...36,567,318
|
|
| G
|
Cnp
|
2',3'-cyclic nucleotide 3' phosphodiesterase
|
decreases expression multiple interactions
|
EXP ISO
|
lead acetate results in decreased expression of CNP protein [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of CNP protein
|
CTD |
PMID:20797405 PMID:23680456 |
|
NCBI chr11:100,465,765...100,472,565
Ensembl chr11:100,465,730...100,482,555
|
|
| G
|
Cntf
|
ciliary neurotrophic factor
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CNTF mRNA
|
CTD |
PMID:33862172 |
|
NCBI chr19:12,740,892...12,742,996
Ensembl chr19:12,741,024...12,742,996
|
|
| G
|
Cntnap2
|
contactin associated protein-like 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CNTNAP2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 6:45,036,995...47,278,330
Ensembl chr 6:45,036,291...47,281,147
|
|
| G
|
Coa6
|
cytochrome c oxidase assembly factor 6
|
increases expression
|
ISO
|
lead acetate results in increased expression of COA6 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:127,149,267...127,152,174
Ensembl chr 8:127,149,254...127,152,172
|
|
| G
|
Cog8
|
component of oligomeric golgi complex 8
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of COG8 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:107,775,341...107,783,369
Ensembl chr 8:107,772,921...107,783,321
|
|
| G
|
Col11a1
|
collagen, type XI, alpha 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL11A1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 3:113,823,933...114,014,405
Ensembl chr 3:113,824,189...114,014,367
|
|
| G
|
Col13a1
|
collagen, type XIII, alpha 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL13A1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr10:61,674,013...61,814,985
Ensembl chr10:61,674,015...61,814,887
|
|
| G
|
Col15a1
|
collagen, type XV, alpha 1
|
decreases expression
|
EXP ISO
|
lead acetate results in decreased expression of COL15A1 mRNA
|
CTD |
PMID:11578147 PMID:22613225 |
|
NCBI chr 4:47,207,744...47,313,165
Ensembl chr 4:47,208,161...47,313,167
|
|
| G
|
Col16a1
|
collagen, type XVI, alpha 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL16A1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 4:129,941,638...129,993,070
Ensembl chr 4:129,941,633...129,993,076
|
|
| G
|
Col18a1
|
collagen, type XVIII, alpha 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL18A1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr10:76,888,013...77,002,351
Ensembl chr10:76,888,012...77,002,382
|
|
| G
|
Col19a1
|
collagen, type XIX, alpha 1
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of COL19A1 mRNA lead acetate results in decreased expression of COL19A1 mRNA
|
CTD |
PMID:11578147 PMID:20542052 |
|
NCBI chr 1:24,296,764...24,627,870
Ensembl chr 1:24,300,971...24,626,553
|
|
| G
|
Col1a1
|
collagen, type I, alpha 1
|
decreases expression affects expression increases expression
|
ISO
|
lead acetate results in decreased expression of COL1A1 mRNA lead acetate affects the expression of COL1A1 protein lead acetate results in increased expression of COL1A1 mRNA
|
CTD |
PMID:11578147 PMID:22641619 PMID:36539177 |
|
NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
|
|
| G
|
Col22a1
|
collagen, type XXII, alpha 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of COL22A1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:71,667,644...71,906,087
Ensembl chr15:71,667,644...71,906,076
|
|
| G
|
Col2a1
|
collagen, type II, alpha 1
|
multiple interactions increases expression decreases expression
|
EXP ISO
|
BMP2 promotes the reaction [lead acetate results in increased expression of COL2A1 mRNA] lead acetate results in decreased expression of COL2A1 mRNA
|
CTD |
PMID:11578147 PMID:17805416 |
|
NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
|
|
| G
|
Col4a1
|
collagen, type IV, alpha 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL4A1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826
|
|
| G
|
Col4a3
|
collagen, type IV, alpha 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of COL4A3 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 1:82,564,647...82,699,778
Ensembl chr 1:82,564,642...82,699,780
|
|
| G
|
Col4a4
|
collagen, type IV, alpha 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL4A4 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 1:82,426,140...82,564,570
Ensembl chr 1:82,426,144...82,564,570
|
|
| G
|
Col4a5
|
collagen, type IV, alpha 5
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL4A5 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr X:140,258,367...140,472,232
Ensembl chr X:140,258,381...140,472,230
|
|
| G
|
Col4a6
|
collagen, type IV, alpha 6
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL4A6 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr X:139,948,399...140,257,091
Ensembl chr X:139,948,399...140,257,072
|
|
| G
|
Col5a2
|
collagen, type V, alpha 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL5A2 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 1:45,413,491...45,542,442
Ensembl chr 1:45,413,481...45,542,442
|
|
| G
|
Col6a1
|
collagen, type VI, alpha 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of COL6A1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr10:76,544,626...76,561,869
Ensembl chr10:76,544,626...76,562,002
|
|
| G
|
Col6a2
|
collagen, type VI, alpha 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of COL6A2 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr10:76,431,590...76,459,464
Ensembl chr10:76,431,596...76,459,464
|
|
| G
|
Col7a1
|
collagen, type VII, alpha 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of COL7A1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 9:108,782,654...108,813,943
Ensembl chr 9:108,782,654...108,813,943
|
|
| G
|
Col8a1
|
collagen, type VIII, alpha 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL8A1 mRNA
|
CTD |
PMID:11578147 PMID:22641619 |
|
NCBI chr16:57,444,619...57,575,100
Ensembl chr16:57,444,621...57,575,100
|
|
| G
|
Col9a1
|
collagen, type IX, alpha 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL9A1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 1:24,216,670...24,291,819
Ensembl chr 1:24,216,691...24,291,765
|
|
| G
|
Col9a3
|
collagen, type IX, alpha 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COL9A3 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 2:180,239,895...180,263,985
Ensembl chr 2:180,239,583...180,263,982
|
|
| G
|
Colgalt1
|
collagen beta(1-O)galactosyltransferase 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of COLGALT1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:72,063,631...72,077,555
Ensembl chr 8:72,063,642...72,077,555
|
|
| G
|
Commd6
|
COMM domain containing 6
|
increases expression
|
ISO
|
lead acetate results in increased expression of COMMD6 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:101,871,202...101,877,907
Ensembl chr14:101,870,417...101,878,122
|
|
| G
|
Coprs
|
coordinator of PRMT5, differentiation stimulator
|
increases expression
|
EXP
|
lead acetate results in increased expression of COPRS mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:13,934,787...13,940,501
Ensembl chr 8:13,934,794...13,940,281
|
|
| G
|
Coq5
|
coenzyme Q5 methyltransferase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of COQ5 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:115,417,752...115,435,029
Ensembl chr 5:115,417,725...115,435,031
|
|
| G
|
Cox17
|
cytochrome c oxidase assembly protein 17, copper chaperone
|
increases expression
|
ISO
|
lead acetate results in increased expression of COX17 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659
|
|
| G
|
Cp
|
ceruloplasmin
|
multiple interactions decreases expression
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of CP mRNA; [Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CP protein]
|
CTD |
PMID:22534743 PMID:39276841 |
|
NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309
|
|
| G
|
Cpa1
|
carboxypeptidase A1, pancreatic
|
increases expression
|
EXP
|
lead acetate results in increased expression of CPA1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 6:30,639,217...30,645,360
Ensembl chr 6:30,639,217...30,645,362
|
|
| G
|
Cpa2
|
carboxypeptidase A2, pancreatic
|
increases expression
|
EXP
|
lead acetate results in increased expression of CPA2 mRNA
|
CTD |
PMID:20542052 PMID:22609695 |
|
NCBI chr 6:30,541,641...30,564,475
Ensembl chr 6:30,541,581...30,564,475
|
|
| G
|
Cpa5
|
carboxypeptidase A5
|
increases expression
|
EXP
|
lead acetate results in increased expression of CPA5 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:30,611,009...30,631,744
Ensembl chr 6:30,611,009...30,631,744
|
|
| G
|
Cpb1
|
carboxypeptidase B1
|
increases expression
|
EXP
|
lead acetate results in increased expression of CPB1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 3:20,303,643...20,339,681
Ensembl chr 3:20,302,428...20,329,897
|
|
| G
|
Cpb2
|
carboxypeptidase B2
|
increases expression
|
EXP
|
lead acetate results in increased expression of CPB2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr14:75,479,727...75,520,995
Ensembl chr14:75,479,727...75,520,995
|
|
| G
|
Cplx4
|
complexin 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CPLX4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr18:66,088,793...66,103,249
Ensembl chr18:66,088,793...66,103,308
|
|
| G
|
Cpne1
|
copine I
|
increases expression
|
EXP
|
lead acetate results in increased expression of CPNE1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:155,913,765...155,953,847
Ensembl chr 2:155,913,762...155,953,885
|
|
| G
|
Cpne2
|
copine II
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CPNE2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:95,259,299...95,297,157
Ensembl chr 8:95,259,618...95,297,159
|
|
| G
|
Cpne7
|
copine VII
|
affects expression
|
ISO
|
lead acetate affects the expression of CPNE7 protein
|
CTD |
PMID:36539177 |
|
NCBI chr 8:123,844,054...123,861,924
Ensembl chr 8:123,844,113...123,861,921
|
|
| G
|
Cpsf3
|
cleavage and polyadenylation specificity factor 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CPSF3 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr12:21,336,298...21,365,057
Ensembl chr12:21,335,392...21,365,057
|
|
| G
|
Cpvl
|
carboxypeptidase, vitellogenic-like
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CPVL mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:53,850,106...53,955,658
Ensembl chr 6:53,850,264...53,955,656
|
|
| G
|
Crabp1
|
cellular retinoic acid binding protein I
|
decreases expression increases expression decreases methylation
|
ISO
|
lead acetate results in decreased expression of CRABP1 mRNA lead acetate results in increased expression of CRABP1 mRNA lead acetate results in decreased methylation of CRABP1 gene
|
CTD |
PMID:22641619 PMID:29571894 |
|
NCBI chr 9:54,672,032...54,680,394
Ensembl chr 9:54,672,032...54,680,394
|
|
| G
|
Cracdl
|
capping protein inhibiting regulator of actin like
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of KIAA1211L mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:37,650,758...37,758,905
Ensembl chr 1:37,650,758...37,759,166
|
|
| G
|
Crb3
|
crumbs family member 3
|
decreases expression increases expression
|
ISO EXP
|
lead acetate results in decreased expression of CRB3 mRNA lead acetate results in increased expression of CRB3 mRNA
|
CTD |
PMID:22609695 PMID:22641619 |
|
NCBI chr17:57,368,583...57,372,920
Ensembl chr17:57,366,105...57,372,918
|
|
| G
|
Creb1
|
cAMP responsive element binding protein 1
|
multiple interactions decreases phosphorylation decreases expression
|
ISO EXP
|
[lead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein]] which results in decreased phosphorylation of CREB1 protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of CREB1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of CREB1 protein; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CREB1 mRNA]; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of CREB1 protein] lead acetate results in decreased phosphorylation of CREB1 protein lead acetate results in decreased expression of CREB1 mRNA 3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in decreased phosphorylation of CREB1 protein]; [lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of CREB1 protein; Quercetin inhibits the reaction [lead acetate results in decreased phosphorylation of CREB1 protein]
|
CTD |
PMID:12480136 PMID:23855546 PMID:24260418 PMID:30905827 PMID:32058320 PMID:33978298 PMID:37385299 More...
|
|
NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
|
|
| G
|
Creb3l2
|
cAMP responsive element binding protein 3-like 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of CREB3L2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:37,307,956...37,419,083
Ensembl chr 6:37,304,190...37,419,081
|
|
| G
|
Creb3l3
|
cAMP responsive element binding protein 3-like 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CREB3L3 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr10:80,920,163...80,934,706
Ensembl chr10:80,920,158...80,934,708
|
|
| G
|
Creb5
|
cAMP responsive element binding protein 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of CREB5 mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 6:53,264,154...53,677,349
Ensembl chr 6:53,264,255...53,677,361
|
|
| G
|
Crhr2
|
corticotropin releasing hormone receptor 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of CRHR2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 6:55,067,033...55,110,001
Ensembl chr 6:55,067,034...55,110,001
|
|
| G
|
Crip2
|
cysteine rich protein 2
|
affects expression
|
ISO
|
lead acetate affects the expression of CRIP2 protein
|
CTD |
PMID:36539177 |
|
NCBI chr12:113,103,856...113,109,126
Ensembl chr12:113,103,856...113,109,126
|
|
| G
|
Crispld1
|
cysteine-rich secretory protein LCCL domain containing 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of CRISPLD1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:17,797,276...17,840,350
Ensembl chr 1:17,797,269...17,836,568
|
|
| G
|
Crispld2
|
cysteine-rich secretory protein LCCL domain containing 2
|
affects expression
|
EXP
|
lead acetate affects the expression of CRISPLD2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:120,719,177...120,779,533
Ensembl chr 8:120,719,177...120,779,532
|
|
| G
|
Crkl
|
v-crk avian sarcoma virus CT10 oncogene homolog-like
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CRKL mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:17,269,849...17,305,304
Ensembl chr16:17,269,851...17,305,298
|
|
| G
|
Crnkl1
|
crooked neck pre-mRNA splicing factor 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CRNKL1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:145,759,402...145,776,620
Ensembl chr 2:145,759,399...145,776,934
|
|
| G
|
Crp
|
C-reactive protein, pentraxin-related
|
multiple interactions increases secretion
|
ISO
|
Curcumin inhibits the reaction [lead acetate results in increased secretion of CRP protein]
|
CTD |
PMID:21378372 |
|
NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
|
|
| G
|
Crx
|
cone-rod homeobox
|
decreases expression multiple interactions
|
ISO EXP
|
lead acetate results in decreased expression of CRX mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of CRX mRNA
|
CTD |
PMID:22641619 PMID:28050121 |
|
NCBI chr 7:15,599,872...15,613,880
Ensembl chr 7:15,599,872...15,613,893
|
|
| G
|
Crxos
|
cone-rod homeobox, opposite strand
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CRXOS mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:15,616,542...15,637,945
Ensembl chr 7:15,616,542...15,637,964
|
|
| G
|
Cryab
|
crystallin, alpha B
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of CRYAB mRNA
|
CTD |
PMID:22609695 PMID:37939567 |
|
NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936
|
|
| G
|
Cryba1
|
crystallin, beta A1
|
increases expression
|
EXP
|
lead acetate results in increased expression of CRYBA1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:77,609,440...77,616,119
Ensembl chr11:77,609,441...77,616,109
|
|
| G
|
Crybg1
|
crystallin beta-gamma domain containing 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of CRYBG1 intron
|
CTD |
PMID:33445541 |
|
NCBI chr10:43,826,303...44,024,824
Ensembl chr10:43,826,632...44,024,849
|
|
| G
|
Cryl1
|
crystallin, lambda 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CRYL1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr14:57,512,491...57,635,940
Ensembl chr14:57,512,450...57,635,986
|
|
| G
|
Cryzl1
|
crystallin zeta like 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of CRYZL1 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr16:91,486,210...91,525,690
Ensembl chr16:91,486,210...91,525,863
|
|
| G
|
Csf1r
|
colony stimulating factor 1 receptor
|
affects expression
|
EXP
|
lead acetate affects the expression of CSF1R mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
|
|
| G
|
Csf2
|
colony stimulating factor 2 (granulocyte-macrophage)
|
multiple interactions
|
EXP
|
[Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD40 protein; [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD80 protein; [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD86 protein; [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of H2 protein; [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of ICAM1 protein; [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of IL10 protein; [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of IL6 protein; [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of TNF protein
|
CTD |
PMID:17512567 |
|
NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
|
|
| G
|
Csf2ra
|
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
|
increases expression
|
EXP
|
lead acetate results in increased expression of CSF2RA mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:61,205,629...61,221,141
Ensembl chr19:61,212,395...61,216,867
|
|
| G
|
Csf3
|
colony stimulating factor 3 (granulocyte)
|
increases expression
|
ISO
|
lead acetate results in increased expression of CSF3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455
|
|
| G
|
Csnk2a2
|
casein kinase 2, alpha prime polypeptide
|
increases expression
|
EXP
|
lead acetate results in increased expression of CSNK2A2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:96,172,724...96,215,505
Ensembl chr 8:96,172,724...96,216,667
|
|
| G
|
Csrp1
|
cysteine and glycine-rich protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of CSRP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:135,614,650...135,679,970
Ensembl chr 1:135,647,799...135,679,970
|
|
| G
|
Csrp2
|
cysteine and glycine-rich protein 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of CSRP2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:110,756,037...110,775,375
Ensembl chr10:110,755,650...110,775,483
|
|
| G
|
Cth
|
cystathionine gamma lyase
|
decreases expression multiple interactions
|
ISO EXP
|
lead acetate results in decreased expression of CTH protein [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CTH mRNA; [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CTH protein sodium bisulfide inhibits the reaction [lead acetate results in decreased expression of CTH protein]; sodium boranocarbonate inhibits the reaction [lead acetate results in decreased expression of CTH protein]
|
CTD |
PMID:30980911 PMID:38157908 |
|
NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714
|
|
| G
|
Ctnna3
|
catenin alpha 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of CTNNA3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr10:63,265,877...64,841,174
Ensembl chr10:63,265,877...64,839,446
|
|
| G
|
Ctnnb1
|
catenin beta 1
|
increases phosphorylation increases expression multiple interactions
|
ISO EXP
|
lead acetate results in increased phosphorylation of CTNNB1 protein lead acetate results in increased expression of CTNNB1 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased localization of CTNNB1 protein WNT7A protein inhibits the reaction [lead acetate results in increased phosphorylation of CTNNB1 protein]
|
CTD |
PMID:24999626 PMID:37436718 PMID:38072110 |
|
NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
|
|
| G
|
Ctps1
|
cytidine 5'-triphosphate synthase 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CTPS1 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 4:120,397,065...120,427,473
Ensembl chr 4:120,397,065...120,427,473
|
|
| G
|
Ctr9
|
CTR9 homolog, Paf1/RNA polymerase II complex component
|
increases expression
|
EXP
|
lead acetate results in increased expression of CTR9 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:110,628,158...110,655,584
Ensembl chr 7:110,628,158...110,655,584
|
|
| G
|
Ctrc
|
chymotrypsin C
|
increases expression
|
EXP
|
lead acetate results in increased expression of CTRC mRNA
|
CTD |
PMID:20542052 PMID:22609695 |
|
NCBI chr 4:141,565,550...141,573,598
Ensembl chr 4:141,565,550...141,573,670
|
|
| G
|
Ctrl
|
chymotrypsin-like
|
increases expression
|
EXP
|
lead acetate results in increased expression of CTRB1 mRNA; lead acetate results in increased expression of CTRL mRNA
|
CTD |
PMID:20542052 PMID:22609695 |
|
NCBI chr 8:106,658,626...106,660,494
Ensembl chr 8:106,658,635...106,660,494
|
|
| G
|
Ctsa
|
cathepsin A
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of CTSA mRNA
|
CTD |
PMID:11578147 PMID:21829687 |
|
NCBI chr 2:164,674,792...164,682,952
Ensembl chr 2:164,674,793...164,682,952
|
|
| G
|
Ctsb
|
cathepsin B
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of CTSB mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372
|
|
| G
|
Ctsc
|
cathepsin C
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CTSC mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:87,927,233...87,960,083
Ensembl chr 7:87,927,293...87,960,096
|
|
| G
|
Ctsd
|
cathepsin D
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CTSD mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
|
|
| G
|
Ctsh
|
cathepsin H
|
increases expression
|
EXP
|
lead acetate results in increased expression of CTSH mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:89,936,320...89,958,148
Ensembl chr 9:89,936,205...89,958,142
|
|
| G
|
Ctsl
|
cathepsin L
|
increases expression
|
ISO
|
lead acetate results in increased expression of CTSL mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704
|
|
| G
|
Ctso
|
cathepsin O
|
increases expression
|
EXP
|
lead acetate results in increased expression of CTSO mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:81,839,908...81,864,032
Ensembl chr 3:81,839,908...81,864,032
|
|
| G
|
Ctsq
|
cathepsin Q
|
increases expression
|
EXP
|
lead acetate results in increased expression of CTSQ mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr13:61,182,852...61,188,411
Ensembl chr13:61,182,838...61,188,445
|
|
| G
|
Ctsz
|
cathepsin Z
|
increases expression
|
EXP
|
lead acetate results in increased expression of CTSZ mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:174,269,287...174,280,832
Ensembl chr 2:174,269,286...174,280,832
|
|
| G
|
Cttn
|
cortactin
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CTTN mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:143,989,468...144,024,743
Ensembl chr 7:143,989,470...144,024,746
|
|
| G
|
Cux1
|
cut-like homeobox 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased expression of CUX1 mRNA
|
CTD |
PMID:33445541 |
|
NCBI chr 5:136,276,989...136,596,429
Ensembl chr 5:136,276,989...136,596,344
|
|
| G
|
Cuzd1
|
CUB and zona pellucida-like domains 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of CUZD1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:130,910,283...130,924,021
Ensembl chr 7:130,910,283...130,924,021
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|
| G
|
Cx3cl1
|
C-X3-C motif chemokine ligand 1
|
increases secretion
|
ISO
|
lead acetate results in increased secretion of CX3CL1 protein
|
CTD |
PMID:17047031 |
|
NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055
|
|
| G
|
Cx3cr1
|
C-X3-C motif chemokine receptor 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of CX3CR1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945
|
|
| G
|
Cxadr
|
coxsackie virus and adenovirus receptor
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CXADR mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr16:78,098,114...78,156,673
Ensembl chr16:78,098,377...78,156,662
|
|
| G
|
Cxcl10
|
C-X-C motif chemokine ligand 10
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of CXCL10 mRNA pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in increased expression of CXCL10 mRNA]
|
CTD |
PMID:36539177 |
|
NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
|
|
| G
|
Cxcl15
|
C-X-C motif chemokine ligand 15
|
multiple interactions increases expression increases secretion
|
EXP ISO
|
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased secretion of CXCL15 protein] lead acetate results in increased expression of CXCL8 mRNA lead acetate results in increased secretion of CXCL8 protein lead acetate promotes the reaction [Hemagglutinins results in increased secretion of CXCL8 protein]
|
CTD |
PMID:22839698 PMID:24530660 PMID:38568856 |
|
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
|
|
| G
|
Cxcl17
|
C-X-C motif chemokine ligand 17
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CXCL17 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:25,099,478...25,112,311
Ensembl chr 7:25,099,478...25,112,311
|
|
| G
|
Cxcr4
|
C-X-C motif chemokine receptor 4
|
multiple interactions decreases expression affects expression
|
ISO EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CXCR4 mRNA lead acetate results in decreased expression of CXCR4 mRNA lead acetate affects the expression of CXCR4 mRNA
|
CTD |
PMID:12634122 PMID:21829687 PMID:38568856 |
|
NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030
|
|
| G
|
Cyb5b
|
cytochrome b5 type B
|
increases expression
|
EXP
|
lead acetate results in increased expression of CYB5B mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:107,877,293...107,914,102
Ensembl chr 8:107,877,272...107,914,103
|
|
| G
|
Cybb
|
cytochrome b-245, beta polypeptide
|
affects expression increases expression
|
EXP ISO
|
lead acetate affects the expression of CYBB mRNA lead acetate results in increased expression of CYBB mRNA lead acetate results in increased expression of CYBB protein
|
CTD |
PMID:15569323 PMID:21829687 PMID:22641619 |
|
NCBI chr X:9,301,493...9,354,005
Ensembl chr X:9,301,491...9,354,010
|
|
| G
|
Cycs
|
cytochrome c, somatic
|
multiple interactions increases expression
|
ISO
|
[[amyloid beta-protein (1-40) co-treated with amyloid beta-protein (25-35)] co-treated with [lead acetate results in increased abundance of Lead]] affects the expression of CYCS protein; [[lead acetate results in increased abundance of Lead] which co-treated with amyloid beta-protein (1-40)] affects the expression of CYCS protein; [[lead acetate results in increased abundance of Lead] which co-treated with amyloid beta-protein (25-35)] affects the expression of CYCS protein; [lead acetate results in increased abundance of Lead] which affects the expression of CYCS protein lead acetate results in increased expression of CYCS mRNA coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of CYCS mRNA]
|
CTD |
PMID:33856607 PMID:35300571 |
|
NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
|
|
| G
|
Cyfip2
|
cytoplasmic FMR1 interacting protein 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CYFIP2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:46,084,676...46,203,686
Ensembl chr11:46,084,677...46,203,686
|
|
| G
|
Cyp11a1
|
cytochrome P450, family 11, subfamily a, polypeptide 1
|
multiple interactions decreases expression decreases activity
|
ISO EXP
|
[cadmium acetate co-treated with lead acetate] results in decreased expression of CYP11A1 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of CYP11A1 mRNA; Glycine inhibits the reaction [lead acetate results in decreased expression of CYP11A1 mRNA]; Taurine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CYP11A1 mRNA] lead acetate results in decreased expression of CYP11A1 protein lead acetate results in decreased expression of CYP11A1 mRNA; lead acetate results in decreased expression of CYP11A1 protein lead acetate results in decreased activity of CYP11A1 protein
|
CTD |
PMID:12647776 PMID:21182167 PMID:22806249 PMID:25270620 PMID:25981801 PMID:36088639 PMID:36484981 More...
|
|
NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
|
|
| G
|
Cyp17a1
|
cytochrome P450, family 17, subfamily a, polypeptide 1
|
increases expression decreases expression
|
EXP
|
lead acetate results in increased expression of CYP17A1 mRNA lead acetate results in decreased expression of CYP17A1 mRNA; lead acetate results in decreased expression of CYP17A1 protein
|
CTD |
PMID:21335049 PMID:22806249 |
|
NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611
|
|
| G
|
Cyp19a1
|
cytochrome P450, family 19, subfamily a, polypeptide 1
|
multiple interactions decreases expression
|
ISO
|
epigallocatechin gallate inhibits the reaction [lead acetate results in decreased expression of CYP19A1 mRNA]
|
CTD |
PMID:31054310 |
|
NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
|
|
| G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of CYP1A1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
|
|
| G
|
Cyp1b1
|
cytochrome P450, family 1, subfamily b, polypeptide 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of CYP1B1 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
|
|
| G
|
Cyp26c1
|
cytochrome P450, family 26, subfamily c, polypeptide 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of CYP26C1 promoter
|
CTD |
PMID:33445541 |
|
NCBI chr19:37,673,560...37,681,774
Ensembl chr19:37,674,029...37,681,846
|
|
| G
|
Cyp27a1
|
cytochrome P450, family 27, subfamily a, polypeptide 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CYP27A1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051
|
|
| G
|
Cyp27b1
|
cytochrome P450, family 27, subfamily b, polypeptide 1
|
decreases expression
|
EXP ISO
|
lead acetate results in decreased expression of CYP27B1 mRNA
|
CTD |
PMID:22609695 PMID:38568856 |
|
NCBI chr10:126,884,115...126,891,897
Ensembl chr10:126,884,119...126,888,875
|
|
| G
|
Cyp2a5
|
cytochrome P450, family 2, subfamily a, polypeptide 5
|
increases expression affects expression
|
EXP
|
lead acetate results in increased expression of CYP2A5 mRNA lead acetate affects the expression of CYP2A5 mRNA
|
CTD |
PMID:26229098 PMID:30623991 |
|
NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
|
|
| G
|
Cyp2b10
|
cytochrome P450, family 2, subfamily b, polypeptide 10
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CYP2B10 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
|
|
| G
|
Cyp2b9
|
cytochrome P450, family 2, subfamily b, polypeptide 9
|
increases expression
|
EXP
|
lead acetate results in increased expression of CYP2B9 mRNA
|
CTD |
PMID:21335049 |
|
NCBI chr 7:25,872,775...25,910,086
Ensembl chr 7:25,872,836...25,910,086
|
|
| G
|
Cyp2c37
|
cytochrome P450, family 2. subfamily c, polypeptide 37
|
increases expression
|
EXP
|
lead acetate results in increased expression of CYP2C37 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr19:39,980,868...40,000,687
Ensembl chr19:39,980,868...40,000,687
|
|
| G
|
Cyp2c68
|
cytochrome P450, family 2, subfamily c, polypeptide 68
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CYP2C68 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr19:39,677,280...39,729,545
Ensembl chr19:39,677,278...39,729,498
|
|
| G
|
Cyp2d12
|
cytochrome P450, family 2, subfamily d, polypeptide 12
|
increases expression
|
EXP
|
lead acetate results in increased expression of CYP2D12 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:82,439,244...82,443,614
Ensembl chr15:82,439,273...82,444,604
|
|
| G
|
Cyp2r1
|
cytochrome P450, family 2, subfamily r, polypeptide 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of CYP2R1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:114,149,358...114,162,283
Ensembl chr 7:114,148,917...114,162,207
|
|
| G
|
Cyp3a13
|
cytochrome P450, family 3, subfamily a, polypeptide 13
|
increases expression
|
ISO
|
lead acetate results in increased expression of CYP3A9 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881
|
|
| G
|
Cyp3a44
|
cytochrome P450, family 3, subfamily a, polypeptide 44
|
increases expression
|
EXP
|
lead acetate results in increased expression of CYP3A44 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:145,710,793...145,742,701
Ensembl chr 5:145,710,793...145,742,684
|
|
| G
|
Cyp4a14
|
cytochrome P450, family 4, subfamily a, polypeptide 14
|
increases expression
|
EXP
|
lead acetate results in increased expression of CYP4A14 mRNA
|
CTD |
PMID:21335049 |
|
NCBI chr 4:115,343,397...115,353,355
Ensembl chr 4:115,343,397...115,353,339
|
|
| G
|
Cyp4b1
|
cytochrome P450, family 4, subfamily b, polypeptide 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CYP4B1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:115,481,895...115,504,918
Ensembl chr 4:115,481,922...115,504,920
|
|
| G
|
Cyp4f16
|
cytochrome P450, family 4, subfamily f, polypeptide 16
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of CYP4F16 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:32,755,517...32,770,772
Ensembl chr17:32,755,532...32,770,772
|
|
| G
|
Cyp4x1
|
cytochrome P450, family 4, subfamily x, polypeptide 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of CYP4X1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:114,963,518...114,991,276
Ensembl chr 4:114,963,520...114,991,478
|
|
| G
|
D16Ertd472e
|
DNA segment, Chr 16, ERATO Doi 472, expressed
|
increases expression
|
EXP
|
lead acetate results in increased expression of D16ERTD472E mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr16:78,337,224...78,373,576
Ensembl chr16:78,337,226...78,373,596
|
|
| G
|
Dab2
|
disabled 2, mitogen-responsive phosphoprotein
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of DAB2 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193
|
|
| G
|
Dao
|
D-amino acid oxidase
|
increases expression
|
ISO EXP
|
lead acetate results in increased expression of DAO mRNA lead acetate results in increased expression of DAO mRNA; lead acetate results in increased expression of DAO protein
|
CTD |
PMID:11578147 PMID:25242007 |
|
NCBI chr 5:114,137,696...114,163,736
Ensembl chr 5:114,141,764...114,163,743
|
|
| G
|
Dapk1
|
death associated protein kinase 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of DAPK1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr13:60,749,506...60,911,005
Ensembl chr13:60,749,761...60,911,005
|
|
| G
|
Dapk2
|
death-associated protein kinase 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DAPK2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:66,065,364...66,179,524
Ensembl chr 9:66,065,505...66,179,524
|
|
| G
|
Dapk3
|
death-associated protein kinase 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of DAPK3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:81,018,821...81,029,031
Ensembl chr10:81,018,839...81,029,031
|
|
| G
|
Dapl1
|
death associated protein-like 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DAPL1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:59,314,997...59,335,364
Ensembl chr 2:59,314,997...59,335,364
|
|
| G
|
Dars1
|
aspartyl-tRNA synthetase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of DARS1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 1:128,291,444...128,345,153
Ensembl chr 1:128,291,444...128,345,105
|
|
| G
|
Dazap1
|
DAZ associated protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of DAZAP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:80,097,168...80,124,242
Ensembl chr10:80,097,320...80,124,242
|
|
| G
|
Dbf4
|
DBF4 zinc finger
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DBF4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:8,446,969...8,472,789
Ensembl chr 5:8,446,973...8,472,716
|
|
| G
|
Dbn1
|
drebrin 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of DBN1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924
|
|
| G
|
Dbndd1
|
dysbindin domain containing 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DBNDD1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:124,231,744...124,245,535
Ensembl chr 8:124,231,457...124,242,202
|
|
| G
|
Dcaf6
|
DDB1 and CUL4 associated factor 6
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DCAF6 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:165,157,069...165,288,475
Ensembl chr 1:165,156,267...165,288,044
|
|
| G
|
Dcstamp
|
dendrocyte expressed seven transmembrane protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of DCSTAMP mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr15:39,609,326...39,624,334
Ensembl chr15:39,609,326...39,624,334
|
|
| G
|
Dctn3
|
dynactin 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of DCTN3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:41,714,798...41,723,213
Ensembl chr 4:41,714,798...41,723,170
|
|
| G
|
Dcun1d1
|
defective in cullin neddylation 1 domain containing 1
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of DCUN1D1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 3:35,946,254...35,991,626
Ensembl chr 3:35,946,254...35,991,594
|
|
| G
|
Dcx
|
doublecortin
|
multiple interactions
|
ISO
|
[lead acetate co-treated with sodium arsenite] results in decreased expression of DCX protein
|
CTD |
PMID:38072110 |
|
NCBI chr X:142,638,838...142,716,392
Ensembl chr X:142,638,838...142,716,307
|
|
| G
|
Dcxr
|
dicarbonyl L-xylulose reductase
|
increases expression
|
EXP
|
lead acetate results in increased expression of DCXR mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:120,615,372...120,618,110
Ensembl chr11:120,616,225...120,618,107
|
|
| G
|
Ddah1
|
dimethylarginine dimethylaminohydrolase 1
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of DDAH1 mRNA
|
CTD |
PMID:11578147 PMID:20680508 |
|
NCBI chr 3:145,464,447...145,600,032
Ensembl chr 3:145,464,430...145,600,032
|
|
| G
|
Ddc
|
dopa decarboxylase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DDC mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144
|
|
| G
|
Ddit3
|
DNA-damage inducible transcript 3
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of DDIT3 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of DDIT3 mRNA lead acetate results in increased expression of DDIT3 protein
|
CTD |
PMID:22811615 PMID:25270620 PMID:39547369 |
|
NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
|
|
| G
|
Ddit4
|
DNA-damage-inducible transcript 4
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of DDIT4 mRNA lead acetate results in decreased expression of DDIT4 mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656
|
|
| G
|
Ddr2
|
discoidin domain receptor family, member 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of DDR2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:169,799,874...169,938,525
Ensembl chr 1:169,799,876...169,938,331
|
|
| G
|
Ddx23
|
DEAD box helicase 23
|
increases expression
|
EXP
|
lead acetate results in increased expression of DDX23 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr15:98,543,012...98,560,808
Ensembl chr15:98,543,015...98,560,775
|
|
| G
|
Ddx39a
|
DEAD box helicase 39a
|
affects expression
|
EXP
|
lead acetate affects the expression of DDX39A mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:84,441,806...84,453,533
Ensembl chr 8:84,441,806...84,453,521
|
|
| G
|
Ddx39b
|
DEAD box helicase 39b
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DDX39B mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:35,460,722...35,472,683
Ensembl chr17:35,460,722...35,472,683
|
|
| G
|
Ddx3y
|
DEAD box helicase 3, Y-linked
|
decreases expression increases expression
|
EXP
|
lead acetate results in decreased expression of DDX3Y mRNA; lead acetate results in decreased expression of DDX3Y protein lead acetate results in increased expression of DDX3Y mRNA
|
CTD |
PMID:22609695 PMID:24140753 |
|
NCBI chr Y:1,260,715...1,286,630
Ensembl chr Y:1,260,771...1,286,629
|
|
| G
|
Ddx54
|
DEAD box helicase 54
|
increases expression
|
ISO
|
lead acetate results in increased expression of DDX54 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:120,751,182...120,766,657
Ensembl chr 5:120,750,804...120,766,657
|
|
| G
|
Dedd2
|
death effector domain-containing DNA binding protein 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of DEDD2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:24,899,337...24,920,035
Ensembl chr 7:24,899,340...24,920,040
|
|
| G
|
Defa-rs2
|
defensin, alpha, related sequence 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of DEFA-RS2 mRNA
|
CTD |
PMID:22609695 |
|
|
|
| G
|
Defb6
|
defensin beta 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of DEFB6 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:19,275,494...19,278,225
Ensembl chr 8:19,275,494...19,278,225
|
|
| G
|
Dennd3
|
DENN domain containing 3
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of DENND3 exon; [lead acetate results in increased abundance of Lead] which results in increased methylation of DENND3 intron
|
CTD |
PMID:33445541 |
|
NCBI chr15:73,384,333...73,444,091
Ensembl chr15:73,384,409...73,444,091
|
|
| G
|
Denr
|
density-regulated protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of DENR mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:124,045,309...124,066,705
Ensembl chr 5:124,045,238...124,066,898
|
|
| G
|
Depp1
|
DEPP1 autophagy regulator
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DEPP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755
|
|
| G
|
Dgcr6
|
DiGeorge syndrome critical region gene 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of DGCR6 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr16:17,870,736...17,889,497
Ensembl chr16:17,870,724...17,889,496
|
|
| G
|
Dgcr8
|
DGCR8, microprocessor complex subunit
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DGCR8 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr16:18,071,812...18,107,115
Ensembl chr16:18,071,812...18,107,110
|
|
| G
|
Dgka
|
diacylglycerol kinase, alpha
|
increases expression
|
ISO
|
lead acetate results in increased expression of DGKA mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr10:128,556,000...128,581,002
Ensembl chr10:128,556,003...128,580,724
|
|
| G
|
Dgki
|
diacylglycerol kinase, iota
|
increases expression
|
ISO
|
lead acetate results in increased expression of DGKI mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 6:36,814,316...37,281,034
Ensembl chr 6:36,822,957...37,277,119
|
|
| G
|
Dgkz
|
diacylglycerol kinase zeta
|
increases expression
|
ISO
|
lead acetate results in increased expression of DGKZ mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:91,763,167...91,806,788
Ensembl chr 2:91,763,169...91,806,209
|
|
| G
|
Dhcr7
|
7-dehydrocholesterol reductase
|
multiple interactions
|
EXP
|
[[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of DHCR7 mRNA; [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of DHCR7 protein
|
CTD |
PMID:38157908 |
|
NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147
|
|
| G
|
Dhrs3
|
dehydrogenase/reductase 3
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of DHRS3 mRNA lead acetate results in increased expression of DHRS3 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779
|
|
| G
|
Dhrs7
|
dehydrogenase/reductase 7
|
increases expression
|
ISO
|
lead acetate results in increased expression of DHRS7 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:72,697,127...72,711,678
Ensembl chr12:72,697,127...72,711,683
|
|
| G
|
Dhtkd1
|
dehydrogenase E1 and transketolase domain containing 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of DHTKD1 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 2:5,901,030...5,947,648
Ensembl chr 2:5,900,926...5,947,603
|
|
| G
|
Dhx29
|
DExH-box helicase 29
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of DHX29 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr13:113,063,976...113,105,968
Ensembl chr13:113,063,988...113,105,966
|
|
| G
|
Dhx58
|
DExH-box helicase 58
|
increases expression
|
EXP
|
lead acetate results in increased expression of DHX58 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097
|
|
| G
|
Diaph2
|
diaphanous related formin 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of DIAPH2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr X:128,650,409...129,366,583
Ensembl chr X:128,650,491...129,366,583
|
|
| G
|
Dio1
|
deiodinase, iodothyronine, type I
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DIO1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:107,148,662...107,164,365
Ensembl chr 4:107,148,662...107,164,366
|
|
| G
|
Dio2
|
deiodinase, iodothyronine, type II
|
increases expression
|
ISO
|
lead acetate results in increased expression of DIO2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812
|
|
| G
|
Dio3os
|
deiodinase, iodothyronine type III, opposite strand
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DIO3OS mRNA
|
CTD |
PMID:27562236 |
|
NCBI chr12:110,241,818...110,244,502
Ensembl chr12:110,241,813...110,244,609
|
|
| G
|
Disc1
|
disrupted in schizophrenia 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of DISC1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 8:125,773,928...125,991,882
Ensembl chr 8:125,780,934...125,988,597
|
|
| G
|
Disp3
|
dispatched RND transporter family member 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of DISP3 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 4:148,320,890...148,372,653
Ensembl chr 4:148,324,721...148,372,422
|
|
| G
|
Dld
|
dihydrolipoamide dehydrogenase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DLD protein
|
CTD |
PMID:25981801 |
|
NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452
|
|
| G
|
Dleu7
|
deleted in lymphocytic leukemia, 7
|
increases expression
|
EXP
|
lead acetate results in increased expression of DLEU7 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr14:62,513,678...62,530,428
Ensembl chr14:62,513,680...62,530,496
|
|
| G
|
Dlg1
|
discs large MAGUK scaffold protein 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of DLG1 protein; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of DLG1 protein]; Hemin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of DLG1 protein]
|
CTD |
PMID:36096218 |
|
NCBI chr16:31,482,261...31,692,174
Ensembl chr16:31,482,261...31,693,947
|
|
| G
|
Dlg4
|
discs large MAGUK scaffold protein 4
|
multiple interactions increases expression affects expression decreases expression
|
EXP ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of DLG4 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of DLG4 protein lead acetate results in increased expression of DLG4 mRNA lead acetate affects the expression of DLG4 protein lead acetate results in decreased expression of DLG4 protein
|
CTD |
PMID:26660114 PMID:27492863 PMID:27984133 |
|
NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348
|
|
| G
|
Dlg5
|
discs large MAGUK scaffold protein 5
|
decreases expression
|
EXP ISO
|
lead acetate results in decreased expression of DLG5 mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr14:24,184,021...24,295,988
Ensembl chr14:24,184,021...24,295,988
|
|
| G
|
Dlgap2
|
DLG associated protein 2
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of DLGAP2 intron
|
CTD |
PMID:33445541 |
|
NCBI chr 8:14,145,793...14,903,426
Ensembl chr 8:14,145,865...14,897,680
|
|
| G
|
Dlk2
|
delta like non-canonical Notch ligand 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DLK2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:46,608,342...46,614,197
Ensembl chr17:46,608,347...46,614,197
|
|
| G
|
Dlx2
|
distal-less homeobox 2
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of DLX2 mRNA
|
CTD |
PMID:22609695 PMID:38568856 |
|
NCBI chr 2:71,373,752...71,377,095
Ensembl chr 2:71,373,752...71,377,098
|
|
| G
|
Dmbt1
|
deleted in malignant brain tumors 1
|
increases expression decreases expression
|
EXP
|
lead acetate results in increased expression of DMBT1 mRNA lead acetate results in decreased expression of DMBT1 mRNA
|
CTD |
PMID:20542052 PMID:22609695 |
|
NCBI chr 7:130,633,787...130,723,357
Ensembl chr 7:130,633,776...130,723,357
|
|
| G
|
Dmrt2
|
doublesex and mab-3 related transcription factor 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DMRT2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:25,649,758...25,656,355
Ensembl chr19:25,649,775...25,656,355
|
|
| G
|
Dnah10
|
dynein, axonemal, heavy chain 10
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of DNAH10 exon
|
CTD |
PMID:33445541 |
|
NCBI chr 5:124,802,149...124,911,372
Ensembl chr 5:124,802,149...124,911,372
|
|
| G
|
Dnaja1
|
DnaJ heat shock protein family (Hsp40) member A1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of DNAJA1 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 4:40,722,468...40,734,965
Ensembl chr 4:40,722,150...40,737,149
|
|
| G
|
Dnajb1
|
DnaJ heat shock protein family (Hsp40) member B1
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of DNAJB1 mRNA [sodium arsenite co-treated with lead acetate] results in increased expression of DNAJB1 protein
|
CTD |
PMID:21829687 PMID:38072110 |
|
NCBI chr 8:84,334,804...84,339,282
Ensembl chr 8:84,334,822...84,339,282
|
|
| G
|
Dnajb4
|
DnaJ heat shock protein family (Hsp40) member B4
|
increases expression
|
ISO
|
lead acetate results in increased expression of DNAJB4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:151,887,217...151,915,720
Ensembl chr 3:151,884,148...151,915,939
|
|
| G
|
Dnajb6
|
DnaJ heat shock protein family (Hsp40) member B6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DNAJB6 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:29,940,896...29,991,476
Ensembl chr 5:29,940,686...30,023,132
|
|
| G
|
Dnajc21
|
DnaJ heat shock protein family (Hsp40) member C21
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DNAJC21 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr15:10,446,849...10,470,685
Ensembl chr15:10,446,842...10,470,602
|
|
| G
|
Dnase2a
|
deoxyribonuclease II alpha
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DNASE2A mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 8:85,635,384...85,638,332
Ensembl chr 8:85,635,189...85,649,544
|
|
| G
|
Dnmt1
|
DNA methyltransferase 1
|
decreases expression multiple interactions increases expression
|
ISO EXP
|
lead acetate results in decreased expression of DNMT1 mRNA; lead acetate results in decreased expression of DNMT1 protein [lead acetate results in increased abundance of Lead] which affects the expression of DNMT1 protein lead acetate results in increased expression of DNMT1 mRNA; lead acetate results in increased expression of DNMT1 protein
|
CTD |
PMID:21117136 PMID:22160880 PMID:22764079 PMID:23246732 PMID:29481626 |
|
NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
|
|
| G
|
Dnmt3a
|
DNA methyltransferase 3A
|
increases expression multiple interactions decreases expression
|
ISO EXP
|
lead acetate results in increased expression of DNMT3A protein [lead acetate results in increased abundance of Lead] which affects the expression of DNMT3A protein lead acetate results in decreased expression of DNMT3A protein
|
CTD |
PMID:23246732 PMID:29481626 |
|
NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443
|
|
| G
|
Dnmt3l
|
DNA methyltransferase 3-like
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of DNMT3L gene
|
CTD |
PMID:29571894 |
|
NCBI chr10:77,878,121...77,899,456
Ensembl chr10:77,877,781...77,899,456
|
|
| G
|
Dnpep
|
aspartyl aminopeptidase
|
increases expression decreases expression
|
EXP
|
lead acetate results in increased expression of DNPEP mRNA lead acetate results in decreased expression of DNPEP mRNA
|
CTD |
PMID:21829687 PMID:22609695 PMID:25270620 |
|
NCBI chr 1:75,285,209...75,294,648
Ensembl chr 1:75,284,540...75,294,634
|
|
| G
|
Dntt
|
deoxynucleotidyltransferase, terminal
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DNTT mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr19:41,017,701...41,047,964
Ensembl chr19:41,017,714...41,047,964
|
|
| G
|
Dock1
|
dedicator of cytokinesis 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of DOCK1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:134,272,416...134,775,376
Ensembl chr 7:134,272,383...134,775,368
|
|
| G
|
Dock4
|
dedicator of cytokinesis 4
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of DOCK4 intron
|
CTD |
PMID:33445541 |
|
NCBI chr12:40,495,956...40,896,873
Ensembl chr12:40,495,951...40,896,873
|
|
| G
|
Dohh
|
deoxyhypusine hydroxylase/monooxygenase
|
increases expression
|
ISO
|
lead acetate results in increased expression of DOHH mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:81,220,268...81,224,186
Ensembl chr10:81,220,262...81,224,186
|
|
| G
|
Dok2
|
docking protein 2
|
affects expression
|
EXP
|
lead acetate affects the expression of DOK2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr14:71,003,336...71,015,934
Ensembl chr14:71,003,476...71,015,935
|
|
| G
|
Dok3
|
docking protein 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of DOK3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr13:55,671,044...55,678,158
Ensembl chr13:55,671,044...55,677,109
|
|
| G
|
Dok5
|
docking protein 5
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DOK5 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 2:170,573,722...170,721,695
Ensembl chr 2:170,573,727...170,721,689
|
|
| G
|
Dpp4
|
dipeptidylpeptidase 4
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DPP4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575
|
|
| G
|
Dppa2
|
developmental pluripotency associated 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of DPPA2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:48,130,637...48,139,876
Ensembl chr16:48,124,271...48,140,086
|
|
| G
|
Dpt
|
dermatopontin
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DPT mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:164,624,232...164,651,843
Ensembl chr 1:164,624,213...164,651,835
|
|
| G
|
Dpyd
|
dihydropyrimidine dehydrogenase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DPYD mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:118,355,758...119,226,573
Ensembl chr 3:118,355,778...119,226,573
|
|
| G
|
Dpysl2
|
dihydropyrimidinase-like 2
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of DPYSL2 protein lead acetate results in decreased expression of DPYSL2 mRNA
|
CTD |
PMID:20797405 PMID:38568856 |
|
NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,148,410
|
|
| G
|
Drap1
|
DR1 associated protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of DRAP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:5,472,832...5,475,007
Ensembl chr19:5,472,833...5,475,007
|
|
| G
|
Drd2
|
dopamine receptor D2
|
multiple interactions increases expression
|
ISO EXP
|
[lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA; [lead acetate co-treated with Morphine] results in increased expression of DRD2 protein [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of DRD2 protein lead acetate results in increased expression of DRD2 mRNA; lead acetate results in increased expression of DRD2 protein
|
CTD |
PMID:23702354 PMID:38157908 |
|
NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
|
|
| G
|
Dsc1
|
desmocollin 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DSC1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr18:20,216,528...20,247,830
Ensembl chr18:20,217,241...20,247,928
|
|
| G
|
Dsc2
|
desmocollin 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DSC2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr18:20,163,690...20,192,611
Ensembl chr18:20,163,690...20,192,611
|
|
| G
|
Dsg3
|
desmoglein 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DSG3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr18:20,643,331...20,674,367
Ensembl chr18:20,643,331...20,680,516
|
|
| G
|
Dsp
|
desmoplakin
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DSP mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr13:38,335,357...38,382,553
Ensembl chr13:38,335,270...38,382,553
|
|
| G
|
Dstn
|
destrin
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of DSTN protein
|
CTD |
PMID:38072110 |
|
NCBI chr 2:143,757,251...143,785,244
Ensembl chr 2:143,757,240...143,785,244
|
|
| G
|
Dtwd1
|
DTW domain containing 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DTWD1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:125,993,981...126,007,197
Ensembl chr 2:125,994,061...126,007,199
|
|
| G
|
Dus1l
|
dihydrouridine synthase 1 like
|
increases expression
|
ISO
|
lead acetate results in increased expression of DUS1L mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:120,678,385...120,687,254
Ensembl chr11:120,680,027...120,687,229
|
|
| G
|
Dusp1
|
dual specificity phosphatase 1
|
multiple interactions increases expression decreases expression
|
ISO EXP
|
[lead acetate results in increased abundance of Lead] which results in increased expression of DUSP1 mRNA lead acetate results in increased expression of DUSP1 mRNA lead acetate results in decreased expression of DUSP1 mRNA
|
CTD |
PMID:21829687 PMID:22641619 PMID:36642386 |
|
NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
|
|
| G
|
Dusp10
|
dual specificity phosphatase 10
|
increases expression
|
EXP
|
lead acetate results in increased expression of DUSP10 mRNA
|
CTD |
PMID:33932463 |
|
NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833
|
|
| G
|
Dusp12
|
dual specificity phosphatase 12
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of DUSP12 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:170,701,756...170,713,109
Ensembl chr 1:170,701,067...170,713,109
|
|
| G
|
Dusp16
|
dual specificity phosphatase 16
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of DUSP16 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:134,692,431...134,769,687
Ensembl chr 6:134,692,431...134,769,588
|
|
| G
|
Dusp23
|
dual specificity phosphatase 23
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of DUSP23 mRNA lead acetate results in decreased expression of DUSP23 mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr 1:172,458,336...172,460,504
Ensembl chr 1:172,458,331...172,460,529
|
|
| G
|
Dusp4
|
dual specificity phosphatase 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of DUSP4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:35,274,448...35,289,106
Ensembl chr 8:35,274,451...35,287,048
|
|
| G
|
Dvl1
|
dishevelled segment polarity protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of DVL1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:155,931,829...155,943,760
Ensembl chr 4:155,931,859...155,943,760
|
|
| G
|
Dync1li1
|
dynein cytoplasmic 1 light intermediate chain 1
|
decreases expression increases methylation
|
ISO
|
lead acetate results in decreased expression of DYNC1LI1 mRNA lead acetate results in increased methylation of DYNC1LI1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 9:114,517,899...114,552,856
Ensembl chr 9:114,517,858...114,553,370
|
|
| G
|
Dynll2
|
dynein light chain LC8-type 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of DYNLL2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:87,870,351...87,892,746
Ensembl chr11:87,870,351...87,878,359
|
|
| G
|
Ear3
|
eosinophil-associated, ribonuclease A family, member 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of EAR3 mRNA
|
CTD |
PMID:21829687 |
|
|
|
| G
|
Ears2
|
glutamyl-tRNA synthetase 2, mitochondrial
|
increases expression
|
EXP
|
lead acetate results in increased expression of EARS2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:121,633,385...121,666,436
Ensembl chr 7:121,636,436...121,666,486
|
|
| G
|
Ebpl
|
emopamil binding protein-like
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of EBPL mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:61,577,212...61,597,894
Ensembl chr14:61,569,191...61,597,888
|
|
| G
|
Ecm1
|
extracellular matrix protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of ECM1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:95,641,459...95,646,880
Ensembl chr 3:95,641,459...95,646,881
|
|
| G
|
Edn2
|
endothelin 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of EDN2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:120,018,403...120,024,557
Ensembl chr 4:120,018,403...120,024,557
|
|
| G
|
Ednrb
|
endothelin receptor type B
|
increases expression
|
ISO
|
lead acetate results in increased expression of EDNRB mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838
|
|
| G
|
Eea1
|
early endosome antigen 1
|
decreases methylation
|
ISO
|
lead acetate results in decreased methylation of EEA1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr10:95,776,525...95,881,380
Ensembl chr10:95,776,512...95,881,380
|
|
| G
|
Efcab2
|
EF-hand calcium binding domain 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of EFCAB2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:178,233,583...178,312,078
Ensembl chr 1:178,233,650...178,312,078
|
|
| G
|
Efemp1
|
epidermal growth factor-containing fibulin-like extracellular matrix protein 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of EFEMP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:28,803,154...28,876,743
Ensembl chr11:28,803,204...28,876,743
|
|
| G
|
Efna1
|
ephrin A1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of EFNA1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:89,179,037...89,188,258
Ensembl chr 3:89,179,040...89,188,449
|
|
| G
|
Efnb2
|
ephrin B2
|
increases expression
|
ISO
|
lead acetate results in increased expression of EFNB2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:8,667,235...8,711,242
Ensembl chr 8:8,667,434...8,711,242
|
|
| G
|
Egf
|
epidermal growth factor
|
increases expression
|
ISO
|
lead acetate results in increased expression of EGF mRNA
|
CTD |
PMID:27562236 |
|
NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
|
|
| G
|
Egfr
|
epidermal growth factor receptor
|
decreases expression increases phosphorylation multiple interactions
|
ISO
|
lead acetate results in decreased expression of EGFR protein lead acetate results in increased phosphorylation of EGFR protein 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased phosphorylation of EGFR protein]; EGFR mutant form inhibits the reaction [lead acetate results in increased activity of PRKCA protein]; EGFR mutant form inhibits the reaction [lead acetate results in increased phosphorylation of SRC protein]; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of EGFR protein]
|
CTD |
PMID:17298174 PMID:19133285 |
|
NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
|
|
| G
|
Egln1
|
egl-9 family hypoxia-inducible factor 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of EGLN1 mRNA]
|
CTD |
PMID:38157908 |
|
NCBI chr 8:125,635,325...125,676,063
Ensembl chr 8:125,635,326...125,676,063
|
|
| G
|
Egln3
|
egl-9 family hypoxia-inducible factor 3
|
decreases expression multiple interactions
|
EXP
|
lead acetate results in decreased expression of EGLN3 mRNA [lead acetate results in increased abundance of Lead] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of EGLN3 mRNA]
|
CTD |
PMID:22609695 PMID:38157908 |
|
NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646
|
|
| G
|
Egr1
|
early growth response 1
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of EGR1 mRNA lead acetate results in increased expression of EGR1 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
|
|
| G
|
Egr2
|
early growth response 2
|
decreases expression increases methylation
|
ISO
|
lead acetate results in decreased expression of EGR2 mRNA lead acetate results in increased methylation of EGR2 gene
|
CTD |
PMID:22641619 PMID:29571894 |
|
NCBI chr10:67,370,334...67,383,354
Ensembl chr10:67,371,305...67,378,018
|
|
| G
|
Ehd2
|
EH-domain containing 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of EHD2 mRNA
|
CTD |
PMID:29746905 |
|
NCBI chr 7:15,680,883...15,701,402
Ensembl chr 7:15,680,883...15,701,492
|
|
| G
|
Ehf
|
ets homologous factor
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of EHF mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:103,093,776...103,133,620
Ensembl chr 2:103,093,778...103,133,623
|
|
| G
|
Eif1ax
|
eukaryotic translation initiation factor 1A, X-linked
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of EIF1AX mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr X:158,155,174...158,172,617
Ensembl chr X:158,155,174...158,172,924
|
|
| G
|
Eif2a
|
eukaryotic translation initiation factor 2A
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of EIF2A protein
|
CTD |
PMID:38072110 |
|
NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922
|
|
| G
|
Eif2ak2
|
eukaryotic translation initiation factor 2-alpha kinase 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of EIF2AK2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002
|
|
| G
|
Eif2ak3
|
eukaryotic translation initiation factor 2 alpha kinase 3
|
increases phosphorylation increases expression multiple interactions
|
ISO
|
lead acetate results in increased phosphorylation of EIF2AK3 protein lead acetate results in increased expression of EIF2AK3 mRNA Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2AK3 protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of EIF2AK3 mRNA]
|
CTD |
PMID:25088297 PMID:38530053 |
|
NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229
|
|
| G
|
Eif2ak4
|
eukaryotic translation initiation factor 2 alpha kinase 4
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of EIF2AK4 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:118,219,065...118,305,715
Ensembl chr 2:118,219,099...118,305,715
|
|
| G
|
Eif2s1
|
eukaryotic translation initiation factor 2, subunit 1 alpha
|
increases phosphorylation multiple interactions
|
ISO
|
lead acetate results in increased phosphorylation of EIF2S1 protein Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2S1 protein]
|
CTD |
PMID:25088297 |
|
NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784
|
|
| G
|
Eif4a1
|
eukaryotic translation initiation factor 4A1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of EIF4A1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:69,557,762...69,563,249
Ensembl chr11:69,557,762...69,563,249
|
|
| G
|
Eif4e3
|
eukaryotic translation initiation factor 4E member 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of EIF4E3 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 6:99,599,008...99,669,834
Ensembl chr 6:99,602,096...99,643,732
|
|
| G
|
Eif4g2
|
eukaryotic translation initiation factor 4, gamma 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of EIF4G2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:110,667,192...110,682,237
Ensembl chr 7:110,666,957...110,682,237
|
|
| G
|
Eif5
|
eukaryotic translation initiation factor 5
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of EIF5 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:111,504,535...111,513,187
Ensembl chr12:111,504,450...111,513,186
|
|
| G
|
Elavl4
|
ELAV like RNA binding protein 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of ELAVL4 mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 4:110,060,934...110,209,127
Ensembl chr 4:110,060,919...110,209,106
|
|
| G
|
Elf2
|
E74-like factor 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of ELF2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:51,160,141...51,248,101
Ensembl chr 3:51,160,141...51,248,084
|
|
| G
|
Elf3
|
E74-like factor 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ELF3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:135,181,312...135,186,210
Ensembl chr 1:135,181,313...135,186,306
|
|
| G
|
Elf5
|
E74-like factor 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ELF5 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:103,242,443...103,281,334
Ensembl chr 2:103,242,033...103,281,334
|
|
| G
|
Elovl1
|
ELOVL fatty acid elongase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of ELOVL1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 4:118,285,321...118,290,150
Ensembl chr 4:118,285,290...118,290,150
|
|
| G
|
Elp6
|
elongator acetyltransferase complex subunit 6
|
affects expression
|
ISO
|
lead acetate affects the expression of ELP6 protein
|
CTD |
PMID:36539177 |
|
NCBI chr 9:110,133,321...110,151,170
Ensembl chr 9:110,134,241...110,151,170
|
|
| G
|
Emcn
|
endomucin
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of EMCN mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:137,046,824...137,136,830
Ensembl chr 3:137,046,828...137,137,946
|
|
| G
|
Emg1
|
EMG1 N1-specific pseudouridine methyltransferase
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of EMG1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:124,681,344...124,689,118
Ensembl chr 6:124,681,048...124,689,141
|
|
| G
|
Eml4
|
echinoderm microtubule associated protein like 4
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of EML4 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr17:83,658,341...83,787,790
Ensembl chr17:83,658,360...83,787,790
|
|
| G
|
Emp1
|
epithelial membrane protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of EMP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:135,339,548...135,360,171
Ensembl chr 6:135,339,543...135,360,171
|
|
| G
|
Endog
|
endonuclease G
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ENDOG mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 2:30,061,525...30,064,057
Ensembl chr 2:30,061,505...30,064,081
|
|
| G
|
Eno1
|
enolase 1, alpha non-neuron
|
increases expression
|
EXP
|
lead acetate results in increased expression of ENO1 protein
|
CTD |
PMID:20797405 |
|
NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336 Ensembl chr18:150,321,178...150,333,336
|
|
| G
|
Eno2
|
enolase 2, gamma neuronal
|
multiple interactions
|
EXP
|
[[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of ENO2 mRNA
|
CTD |
PMID:38157908 |
|
NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636
|
|
| G
|
Eno3
|
enolase 3, beta muscle
|
increases expression
|
EXP
|
lead acetate results in increased expression of ENO3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:70,543,973...70,553,339
Ensembl chr11:70,548,028...70,553,339
|
|
| G
|
Enpp1
|
ectonucleotide pyrophosphatase/phosphodiesterase 1
|
multiple interactions
|
EXP
|
[[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of ENPP1 protein
|
CTD |
PMID:38157908 |
|
NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057
|
|
| G
|
Enpp2
|
ectonucleotide pyrophosphatase/phosphodiesterase 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ENPP2 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288
|
|
| G
|
Enpp6
|
ectonucleotide pyrophosphatase/phosphodiesterase 6
|
increases expression
|
ISO
|
lead acetate results in increased expression of ENPP6 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 8:47,439,920...47,549,797
Ensembl chr 8:47,439,922...47,549,797
|
|
| G
|
Entpd2
|
ectonucleoside triphosphate diphosphohydrolase 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ENTPD2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:25,285,886...25,291,335
Ensembl chr 2:25,285,886...25,291,333
|
|
| G
|
Entpd5
|
ectonucleoside triphosphate diphosphohydrolase 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of ENTPD5 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr12:84,420,649...84,455,803
Ensembl chr12:84,420,631...84,455,803
|
|
| G
|
Entpd8
|
ectonucleoside triphosphate diphosphohydrolase 8
|
increases expression
|
EXP
|
lead acetate results in increased expression of ENTPD8 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:24,969,308...24,975,731
Ensembl chr 2:24,970,316...24,975,728
|
|
| G
|
Epb41l3
|
erythrocyte membrane protein band 4.1 like 3
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPB41L3 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr17:69,382,642...69,596,986
Ensembl chr17:69,382,678...69,596,984
|
|
| G
|
Epcam
|
epithelial cell adhesion molecule
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of EPCAM mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:87,943,407...87,958,555
Ensembl chr17:87,943,407...87,958,557
|
|
| G
|
Epgn
|
epithelial mitogen
|
increases expression
|
ISO
|
lead acetate results in increased expression of EPGN mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:91,175,376...91,183,071
Ensembl chr 5:91,175,323...91,183,074
|
|
| G
|
Epha2
|
Eph receptor A2
|
increases expression
|
ISO
|
lead acetate results in increased expression of EPHA2 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 4:141,028,532...141,056,695
Ensembl chr 4:141,028,551...141,056,695
|
|
| G
|
Epha5
|
Eph receptor A5
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of EPHA5 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 5:84,199,024...84,565,677
Ensembl chr 5:84,202,620...84,565,241
|
|
| G
|
Epha8
|
Eph receptor A8
|
increases expression
|
ISO
|
lead acetate results in increased expression of EPHA8 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 4:136,656,729...136,684,170
Ensembl chr 4:136,656,730...136,684,127
|
|
| G
|
Ephb1
|
Eph receptor B1
|
increases expression
|
EXP
|
lead acetate results in increased expression of EPHB1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 9:101,799,327...102,231,892
Ensembl chr 9:101,799,327...102,231,892
|
|
| G
|
Ephb3
|
Eph receptor B3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of EPHB3 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr16:21,023,530...21,042,054
Ensembl chr16:21,023,505...21,042,055
|
|
| G
|
Ephx1
|
epoxide hydrolase 1, microsomal
|
increases expression
|
ISO
|
lead acetate results in increased expression of EPHX1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469
|
|
| G
|
Ephx2
|
epoxide hydrolase 2, cytoplasmic
|
affects expression
|
ISO
|
lead acetate affects the expression of EPHX2 mRNA
|
CTD |
PMID:21864555 PMID:22641619 |
|
NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949
|
|
| G
|
Epn1
|
epsin 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of EPN1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:5,083,207...5,101,178
Ensembl chr 7:5,083,234...5,101,177
|
|
| G
|
Eprs1
|
glutamyl-prolyl-tRNA synthetase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of EPRS1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 1:185,093,614...185,160,557
Ensembl chr 1:185,095,241...185,160,557
|
|
| G
|
Epx
|
eosinophil peroxidase
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of EPX mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:87,754,824...87,766,362
Ensembl chr11:87,754,826...87,766,362
|
|
| G
|
Eras
|
ES cell-expressed Ras
|
increases expression decreases expression
|
EXP
|
lead acetate results in increased expression of ERAS mRNA lead acetate results in decreased expression of ERAS mRNA
|
CTD |
PMID:22609695 PMID:25270620 |
|
NCBI chr X:7,790,515...7,794,846
Ensembl chr X:7,790,515...7,794,846
|
|
| G
|
Erbb3
|
erb-b2 receptor tyrosine kinase 3
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERBB3 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr10:128,403,392...128,425,504
Ensembl chr10:128,403,392...128,425,521
|
|
| G
|
Ercc1
|
excision repair cross-complementing rodent repair deficiency, complementation group 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ERCC1 mRNA
|
CTD |
PMID:33862172 |
|
NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449
|
|
| G
|
Ercc2
|
excision repair cross-complementing rodent repair deficiency, complementation group 2
|
multiple interactions increases expression
|
ISO EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC2 mRNA lead acetate results in increased expression of ERCC2 mRNA
|
CTD |
PMID:12634122 PMID:29746905 |
|
NCBI chr 7:19,115,942...19,129,619
Ensembl chr 7:19,115,935...19,129,619
|
|
| G
|
Ercc5
|
excision repair cross-complementing rodent repair deficiency, complementation group 5
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ERCC5 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 1:44,184,084...44,220,399
Ensembl chr 1:44,186,904...44,220,420
|
|
| G
|
Ereg
|
epiregulin
|
increases expression
|
ISO
|
lead acetate results in increased expression of EREG mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
|
|
| G
|
Eri2
|
exoribonuclease 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of ERI2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:119,383,049...119,393,283
Ensembl chr 7:119,367,902...119,393,281
|
|
| G
|
Ern1
|
endoplasmic reticulum to nucleus signalling 1
|
increases expression increases phosphorylation multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of ERN1 mRNA lead acetate results in increased phosphorylation of ERN1 protein Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of ERN1 protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of ERN1 mRNA]
|
CTD |
PMID:21829687 PMID:25088297 PMID:38530053 |
|
NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678
|
|
| G
|
Errfi1
|
ERBB receptor feedback inhibitor 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ERRFI1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:150,938,253...150,953,346
Ensembl chr 4:150,938,376...150,953,349
|
|
| G
|
Erv3
|
endogenous retroviral sequence 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ERV3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:131,695,598...131,701,667
Ensembl chr 2:131,695,598...131,701,667
|
|
| G
|
Esm1
|
endothelial cell-specific molecule 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ESM1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr13:113,346,193...113,354,638
Ensembl chr13:113,346,193...113,354,632
|
|
| G
|
Esrp2
|
epithelial splicing regulatory protein 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of ESRP2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:106,856,658...106,863,825
Ensembl chr 8:106,856,951...106,863,606
|
|
| G
|
Etf1
|
eukaryotic translation termination factor 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of ETF1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr18:35,035,838...35,065,060
Ensembl chr18:35,035,838...35,065,060
|
|
| G
|
Etfa
|
electron transferring flavoprotein, alpha polypeptide
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of ETFA protein
|
CTD |
PMID:38072110 |
|
NCBI chr 9:55,361,720...55,419,528
Ensembl chr 9:55,361,792...55,419,527
|
|
| G
|
Etfb
|
electron transferring flavoprotein, beta polypeptide
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of ETFB mRNA lead acetate results in decreased expression of ETFB mRNA
|
CTD |
PMID:20542052 PMID:22641619 |
|
NCBI chr 7:43,093,496...43,107,224
Ensembl chr 7:43,093,507...43,107,224
|
|
| G
|
Etfbkmt
|
electron transfer flavoprotein beta subunit lysine methyltransferase
|
increases expression
|
ISO
|
lead acetate results in increased expression of ETFBKMT mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:149,042,980...149,052,669
Ensembl chr 6:149,041,347...149,052,669
|
|
| G
|
Etnk2
|
ethanolamine kinase 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ETNK2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:133,291,308...133,308,056
Ensembl chr 1:133,291,310...133,308,074
|
|
| G
|
Ets2
|
E26 avian leukemia oncogene 2, 3' domain
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ETS2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr16:95,503,274...95,522,093
Ensembl chr16:95,502,942...95,522,095
|
|
| G
|
Etv4
|
ets variant 4
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of ETV4 exon
|
CTD |
PMID:33445541 |
|
NCBI chr11:101,660,573...101,677,963
Ensembl chr11:101,660,568...101,676,197
|
|
| G
|
Evl
|
Ena-vasodilator stimulated phosphoprotein
|
increases expression
|
ISO
|
lead acetate results in increased expression of EVL mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr12:108,520,942...108,654,775
Ensembl chr12:108,520,979...108,654,775
|
|
| G
|
Eya4
|
EYA transcriptional coactivator and phosphatase 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of EYA4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr10:22,978,861...23,226,785
Ensembl chr10:22,978,862...23,226,684
|
|
| G
|
F13a1
|
coagulation factor XIII, A1 subunit
|
increases expression
|
ISO
|
lead acetate results in increased expression of F13A1 mRNA
|
CTD |
PMID:27562236 |
|
NCBI chr13:37,051,150...37,234,220
Ensembl chr13:37,051,152...37,234,220
|
|
| G
|
F2r
|
coagulation factor II thrombin receptor
|
decreases expression
|
EXP ISO
|
lead acetate results in decreased expression of F2R mRNA
|
CTD |
PMID:22613225 PMID:38568856 |
|
NCBI chr13:95,738,288...95,754,974
Ensembl chr13:95,738,311...95,754,995
|
|
| G
|
F2rl2
|
coagulation factor II thrombin receptor like 2
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of F2RL2 mRNA; lead acetate results in increased expression of F2RL2 protein F2RL2 protein inhibits the reaction [lead acetate results in increased expression of GFAP mRNA]; F2RL2 protein inhibits the reaction [lead acetate results in increased expression of NES mRNA]; F2RL2 protein promotes the reaction [lead acetate results in increased expression of OLIG2 mRNA]
|
CTD |
PMID:27562236 PMID:37939567 |
|
NCBI chr13:95,833,428...95,839,276
Ensembl chr13:95,833,361...95,839,247
|
|
| G
|
F3
|
coagulation factor III, tissue factor
|
increases expression
|
ISO
|
lead acetate results in increased expression of F3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
|
|
| G
|
F5
|
coagulation factor V
|
affects expression
|
ISO
|
lead acetate affects the expression of F5 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846
|
|
| G
|
Fa2h
|
fatty acid 2-hydroxylase
|
increases expression
|
EXP
|
lead acetate results in increased expression of FA2H mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 8:112,071,770...112,120,453
Ensembl chr 8:112,071,767...112,120,456
|
|
| G
|
Fabp4
|
fatty acid binding protein 4, adipocyte
|
decreases expression increases expression affects methylation
|
EXP ISO
|
lead acetate results in decreased expression of FABP4 mRNA lead acetate results in increased expression of FABP4 mRNA lead acetate affects the methylation of FABP4 gene
|
CTD |
PMID:22609695 PMID:29571894 |
|
NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
|
|
| G
|
Fabp9
|
fatty acid binding protein 9, testis
|
increases expression multiple interactions
|
EXP
|
lead acetate results in increased expression of FABP9 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of FABP9 protein
|
CTD |
PMID:22609695 PMID:32142724 |
|
NCBI chr 3:10,258,683...10,262,343
Ensembl chr 3:10,258,681...10,262,343
|
|
| G
|
Fads1
|
fatty acid desaturase 1
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of FADS1 mRNA [sodium arsenite co-treated with lead acetate] results in decreased expression of FADS1 protein
|
CTD |
PMID:38072110 PMID:38568856 |
|
NCBI chr19:10,160,245...10,174,238
Ensembl chr19:10,160,252...10,174,241
|
|
| G
|
Fah
|
fumarylacetoacetate hydrolase
|
increases expression
|
ISO
|
lead acetate results in increased expression of FAH mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:84,234,367...84,255,150
Ensembl chr 7:84,234,367...84,255,930
|
|
| G
|
Fam167a
|
family with sequence similarity 167, member A
|
increases expression
|
ISO
|
lead acetate results in increased expression of FAM167A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:63,673,843...63,702,951
Ensembl chr14:63,673,843...63,702,947
|
|
| G
|
Fam185a
|
family with sequence similarity 185, member A
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FAM185A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:21,629,861...21,693,269
Ensembl chr 5:21,629,956...21,687,122
|
|
| G
|
Fam20c
|
FAM20C, golgi associated secretory pathway kinase
|
increases expression
|
ISO
|
lead acetate results in increased expression of FAM20C mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:138,740,836...138,795,818
Ensembl chr 5:138,740,269...138,795,832
|
|
| G
|
Fam219a
|
family with sequence similarity 219, member A
|
increases expression
|
ISO
|
lead acetate results in increased expression of FAM219A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:41,517,691...41,569,538
Ensembl chr 4:41,517,691...41,569,538
|
|
| G
|
Fam81b
|
family with sequence similarity 81, member B
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FAM81B mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr13:76,349,827...76,427,034
Ensembl chr13:76,349,827...76,453,191
|
|
| G
|
Fam83d
|
family with sequence similarity 83, member D
|
increases expression
|
ISO
|
lead acetate results in increased expression of FAM83D mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:158,610,011...158,628,557
Ensembl chr 2:158,610,013...158,628,557
|
|
| G
|
Fam83h
|
family with sequence similarity 83, member H
|
increases expression
|
ISO
|
lead acetate results in increased expression of FAM83H mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:75,872,941...75,886,185
Ensembl chr15:75,872,942...75,886,185
|
|
| G
|
Fam98c
|
family with sequence similarity 98, member C
|
increases expression
|
ISO
|
lead acetate results in increased expression of FAM98C mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:28,851,935...28,855,653
Ensembl chr 7:28,851,935...28,855,659
|
|
| G
|
Fan1
|
FANCD2/FANCI-associated nuclease 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of FAN1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:63,994,627...64,023,874
Ensembl chr 7:63,996,506...64,023,843
|
|
| G
|
Fanca
|
Fanconi anemia, complementation group A
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FANCA mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:123,993,033...124,045,390
Ensembl chr 8:123,995,039...124,045,315
|
|
| G
|
Farsa
|
phenylalanyl-tRNA synthetase, alpha subunit
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FARSA mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 8:85,583,597...85,595,886
Ensembl chr 8:85,583,618...85,595,886
|
|
| G
|
Fas
|
Fas cell surface death receptor
|
multiple interactions
|
EXP
|
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]; lead acetate affects the localization of and results in increased activity of FAS protein; S-allylcysteine inhibits the reaction [lead acetate affects the localization of and results in increased activity of FAS protein]
|
CTD |
PMID:22033380 |
|
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
|
|
| G
|
Fasn
|
fatty acid synthase
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of FASN mRNA lead acetate results in increased expression of FASN protein SRT1720 inhibits the reaction [lead acetate results in increased expression of FASN protein]
|
CTD |
PMID:30623991 PMID:34842334 |
|
NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
|
|
| G
|
Fat1
|
FAT atypical cadherin 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of FAT1 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 8:45,386,137...45,505,294
Ensembl chr 8:45,388,484...45,505,294
|
|
| G
|
Fbl
|
fibrillarin
|
affects localization
|
ISO
|
lead acetate affects the localization of FBL protein
|
CTD |
PMID:10942594 |
|
NCBI chr 7:27,868,293...27,878,701
Ensembl chr 7:27,869,135...27,878,694
|
|
| G
|
Fblim1
|
filamin binding LIM protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of FBLIM1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:141,303,373...141,333,351
Ensembl chr 4:141,303,373...141,333,407
|
|
| G
|
Fbln2
|
fibulin 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FBLN2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:91,189,442...91,249,522
Ensembl chr 6:91,189,437...91,249,522
|
|
| G
|
Fbn1
|
fibrillin 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of FBN1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913
|
|
| G
|
Fbxl3
|
F-box and leucine-rich repeat protein 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FBXL3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr14:103,318,470...103,337,016
Ensembl chr14:103,317,675...103,337,002
|
|
| G
|
Fbxl6
|
F-box and leucine-rich repeat protein 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FBXL6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr15:76,419,923...76,422,946
Ensembl chr15:76,419,921...76,422,946
|
|
| G
|
Fbxo32
|
F-box protein 32
|
increases expression
|
EXP
|
lead acetate results in increased expression of FBXO32 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr15:58,039,275...58,078,288
Ensembl chr15:58,039,275...58,078,328
|
|
| G
|
Fbxo33
|
F-box protein 33
|
increases expression
|
EXP
|
lead acetate results in increased expression of FBXO33 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr12:59,247,441...59,268,747
Ensembl chr12:59,247,441...59,266,511
|
|
| G
|
Fbxo39
|
F-box protein 39
|
increases expression
|
ISO
|
lead acetate results in increased expression of FBXO39 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:72,205,270...72,210,245
Ensembl chr11:72,205,270...72,210,242
|
|
| G
|
Fbxo45
|
F-box protein 45
|
increases expression
|
ISO
|
lead acetate results in increased expression of FBXO45 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr16:32,048,930...32,065,843
Ensembl chr16:32,048,930...32,065,976
|
|
| G
|
Fbxo6
|
F-box protein 6
|
affects expression
|
ISO
|
lead acetate affects the expression of FBXO6 protein
|
CTD |
PMID:36539177 |
|
NCBI chr 4:148,230,173...148,236,592
Ensembl chr 4:148,230,173...148,236,597
|
|
| G
|
Fbxo9
|
F-box protein 9
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FBXO9 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:77,988,781...78,016,347
Ensembl chr 9:77,988,781...78,016,347
|
|
| G
|
Fbxw13
|
F-box and WD-40 domain protein 13
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FBXW12 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 9:109,008,295...109,025,043
Ensembl chr 9:109,008,295...109,025,043
|
|
| G
|
Fcer2a
|
Fc receptor, IgE, low affinity II, alpha polypeptide
|
increases expression
|
EXP
|
lead acetate results in increased expression of FCER2A mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:3,730,280...3,744,174
Ensembl chr 8:3,731,737...3,744,175
|
|
| G
|
Fcgr4
|
Fc receptor, IgG, low affinity IV
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FCGR4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:170,846,495...170,857,330
Ensembl chr 1:170,846,489...170,857,330
|
|
| G
|
Fcgrt
|
Fc fragment of IgG receptor and transporter
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FCGRT mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:44,742,417...44,753,246
Ensembl chr 7:44,742,414...44,753,275
|
|
| G
|
Fcrl2
|
Fc receptor like 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FCRL2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:87,158,318...87,171,046
Ensembl chr 3:87,158,065...87,171,045
|
|
| G
|
Fermt1
|
fermitin family member 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FERMT1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:132,746,097...132,787,956
Ensembl chr 2:132,746,309...132,787,826
|
|
| G
|
Fga
|
fibrinogen alpha chain
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FGA mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934
|
|
| G
|
Fgb
|
fibrinogen beta chain
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FGB mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 3:82,949,553...82,957,170
Ensembl chr 3:82,947,448...82,957,170
|
|
| G
|
Fgf1
|
fibroblast growth factor 1
|
affects expression
|
ISO
|
lead acetate affects the expression of FGF1 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525
|
|
| G
|
Fgf18
|
fibroblast growth factor 18
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FGF18 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:33,066,970...33,097,400
Ensembl chr11:33,067,430...33,097,400
|
|
| G
|
Fgf2
|
fibroblast growth factor 2
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of FGF2 mRNA lead acetate results in increased expression of FGF2 mRNA
|
CTD |
PMID:22160880 PMID:38568856 |
|
NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
|
|
| G
|
Fgf21
|
fibroblast growth factor 21
|
increases expression
|
EXP
|
lead acetate results in increased expression of FGF21 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914
|
|
| G
|
Fgfbp1
|
fibroblast growth factor binding protein 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FGFBP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:44,136,200...44,139,173
Ensembl chr 5:44,136,200...44,139,121
|
|
| G
|
Fgfr1
|
fibroblast growth factor receptor 1
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FGFR1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734
|
|
| G
|
Fgfr4
|
fibroblast growth factor receptor 4
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FGFR4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr13:55,300,631...55,316,572
Ensembl chr13:55,300,453...55,316,572
|
|
| G
|
Fgfrl1
|
fibroblast growth factor receptor-like 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of FGFRL1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:108,842,051...108,854,816
Ensembl chr 5:108,840,248...108,854,790
|
|
| G
|
Fgg
|
fibrinogen gamma chain
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FGG mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 3:82,915,031...82,922,363
Ensembl chr 3:82,915,031...82,922,356
|
|
| G
|
Fgl1
|
fibrinogen-like protein 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FGL1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:41,644,471...41,671,015
Ensembl chr 8:41,644,471...41,668,193
|
|
| G
|
Fhip1a
|
FHF complex subunit HOOK interacting protein 1A
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FHIP1A mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:85,567,370...85,653,516
Ensembl chr 3:85,567,368...85,724,598
|
|
| G
|
Fhl2
|
four and a half LIM domains 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of FHL2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:43,162,233...43,237,501
Ensembl chr 1:43,162,234...43,236,144
|
|
| G
|
Fibin
|
fin bud initiation factor homolog (zebrafish)
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FIBIN mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:110,191,270...110,193,338
Ensembl chr 2:110,191,262...110,193,528
|
|
| G
|
Fkbp5
|
FK506 binding protein 5
|
increases expression increases methylation
|
ISO
|
lead acetate results in increased expression of FKBP5 mRNA lead acetate results in increased methylation of FKBP5 gene
|
CTD |
PMID:22641619 PMID:29571894 |
|
NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501
|
|
| G
|
Flg2
|
filaggrin family member 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FLG2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:93,104,585...93,128,701
Ensembl chr 3:93,104,585...93,128,698
|
|
| G
|
Flna
|
filamin, alpha
|
increases expression
|
ISO
|
lead acetate results in increased expression of FLNA mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr X:73,267,067...73,293,787
Ensembl chr X:73,267,067...73,293,426
|
|
| G
|
Flrt2
|
fibronectin leucine rich transmembrane protein 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of FLRT2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:95,658,780...95,751,989
Ensembl chr12:95,659,000...95,751,989
|
|
| G
|
Flt4
|
FMS-like tyrosine kinase 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of FLT4 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr11:49,500,506...49,543,566
Ensembl chr11:49,500,090...49,543,566
|
|
| G
|
Fmnl3
|
formin-like 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FMNL3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:99,215,091...99,268,375
Ensembl chr15:99,215,106...99,268,363
|
|
| G
|
Fmo2
|
flavin containing monooxygenase 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FMO2 mRNA
|
CTD |
PMID:29746905 |
|
NCBI chr 1:162,701,886...162,726,327
Ensembl chr 1:162,701,886...162,726,295
|
|
| G
|
Fmo5
|
flavin containing monooxygenase 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FMO5 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 3:97,517,248...97,562,603
Ensembl chr 3:97,536,120...97,562,598
|
|
| G
|
Fmr1
|
fragile X messenger ribonucleoprotein 1
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of FMR1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr X:67,722,144...67,761,569
Ensembl chr X:67,722,147...67,761,569
|
|
| G
|
Fn1
|
fibronectin 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of FN1 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
|
|
| G
|
Fndc3a
|
fibronectin type III domain containing 3A
|
increases expression
|
EXP
|
lead acetate results in increased expression of FNDC3A mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr14:72,775,388...72,948,141
Ensembl chr14:72,775,386...72,947,443
|
|
| G
|
Folh1
|
folate hydrolase 1
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of FOLH1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 7:86,365,733...86,425,171
Ensembl chr 7:86,368,185...86,425,151
|
|
| G
|
Folr1
|
folate receptor alpha
|
affects expression
|
ISO
|
lead acetate affects the expression of FOLR1 mRNA
|
CTD |
PMID:21864555 PMID:22641619 |
|
NCBI chr 7:101,507,551...101,519,974
Ensembl chr 7:101,507,538...101,519,995
|
|
| G
|
Fos
|
FBJ osteosarcoma oncogene
|
multiple interactions decreases expression increases expression
|
ISO EXP
|
lead acetate affects the reaction [Amphetamine results in increased expression of FOS protein]; lead acetate inhibits the reaction [HSPA5 protein binds to FOS enhancer] lead acetate results in decreased expression of FOS mRNA lead acetate results in increased expression of FOS protein
|
CTD |
PMID:15111246 PMID:15111640 PMID:21829687 PMID:22641619 PMID:33862172 PMID:38568856 More...
|
|
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
|
|
| G
|
Fosl1
|
fos-like antigen 1
|
multiple interactions increases expression
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of FOSL1 mRNA lead acetate results in increased expression of FOSL1 mRNA
|
CTD |
PMID:12634122 PMID:38568856 |
|
NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974
|
|
| G
|
Foxd4
|
forkhead box D4
|
increases expression
|
EXP
|
lead acetate results in increased expression of FOXD4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr19:24,876,307...24,878,380
Ensembl chr19:24,876,600...24,878,561
|
|
| G
|
Foxo1
|
forkhead box O1
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of FOXO1 mRNA sinapinic acid affects the reaction [lead acetate results in decreased expression of FOXO1 mRNA]
|
CTD |
PMID:38530053 |
|
NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
|
|
| G
|
Foxp2
|
forkhead box P2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FOXP2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 6:14,901,348...15,441,976
Ensembl chr 6:14,901,348...15,441,976
|
|
| G
|
Foxp3
|
forkhead box P3
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of FOXP3 mRNA lead acetate results in increased expression of FOXP3 protein
|
CTD |
PMID:20542052 PMID:23058909 |
|
NCBI chr X:7,445,915...7,461,482
Ensembl chr X:7,439,883...7,461,484
|
|
| G
|
Foxp4
|
forkhead box P4
|
increases expression
|
ISO
|
lead acetate results in increased expression of FOXP4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:48,178,058...48,235,401
Ensembl chr17:48,178,058...48,235,570
|
|
| G
|
Frem2
|
Fras1 related extracellular matrix protein 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of FREM2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 3:53,421,359...53,566,014
Ensembl chr 3:53,421,359...53,564,776
|
|
| G
|
Frk
|
fyn-related kinase
|
increases expression
|
ISO
|
lead acetate results in increased expression of FRK mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr10:34,359,396...34,487,530
Ensembl chr10:34,359,395...34,487,274
|
|
| G
|
Frmd3
|
FERM domain containing 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FRMD3 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 4:73,931,454...74,120,451
Ensembl chr 4:73,931,679...74,120,451
|
|
| G
|
Frmd4b
|
FERM domain containing 4B
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of FRMD4B mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:97,263,828...97,594,618
Ensembl chr 6:97,263,828...97,594,502
|
|
| G
|
Fry
|
FRY microtubule binding protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of FRY mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:150,042,083...150,421,218
Ensembl chr 5:150,042,110...150,421,218
|
|
| G
|
Fshb
|
follicle stimulating hormone beta
|
decreases secretion multiple interactions
|
ISO
|
lead acetate results in decreased secretion of FSHB protein Cholecalciferol inhibits the reaction [lead acetate results in decreased secretion of FSHB protein]
|
CTD |
PMID:34051273 |
|
NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
|
|
| G
|
Fstl3
|
follistatin-like 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of FSTL3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:79,613,108...79,618,464
Ensembl chr10:79,613,106...79,618,464
|
|
| G
|
Fth1
|
ferritin heavy polypeptide 1
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of FTH1 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of FTH1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of FTH1 protein; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of FTH1 mRNA]; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of FTH1 protein]; ferrostatin-1 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of FTH1 mRNA]
|
CTD |
PMID:20542052 PMID:37939567 PMID:38568856 PMID:39276841 |
|
NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
|
|
| G
|
Ftl1
|
ferritin light polypeptide 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of FTL mRNA
|
CTD |
PMID:11578147 PMID:27562236 PMID:37939567 PMID:38568856 |
|
NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308
|
|
| G
|
Fut4
|
fucosyltransferase 4
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of FUT4 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 9:14,659,755...14,663,418
Ensembl chr 9:14,659,616...14,663,689
|
|
| G
|
Fxn
|
frataxin
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of FXN mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr19:24,236,909...24,257,954
Ensembl chr19:24,238,817...24,257,969
|
|
| G
|
Fxr2
|
FMR1 autosomal homolog 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of FXR2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:69,523,788...69,544,123
Ensembl chr11:69,523,816...69,544,123
|
|
| G
|
Fyb2
|
FYN binding protein 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FYB2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 4:104,692,431...104,874,061
Ensembl chr 4:104,770,653...104,874,060
|
|
| G
|
Fyn
|
Fyn proto-oncogene
|
multiple interactions increases activity
|
ISO
|
FYN protein affects the reaction [lead acetate results in decreased expression of PDGFRA protein] lead acetate results in increased activity of FYN protein
|
CTD |
PMID:17298174 |
|
NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377
|
|
| G
|
Fzd10
|
frizzled class receptor 10
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of FZD10 mRNA]
|
CTD |
PMID:38157908 |
|
NCBI chr 5:128,678,170...128,681,157
Ensembl chr 5:128,677,908...128,681,157
|
|
| G
|
Fzd2
|
frizzled class receptor 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FZD2 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr11:102,495,257...102,498,884
Ensembl chr11:102,495,222...102,498,884
|
|
| G
|
Fzd8
|
frizzled class receptor 8
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of FZD8 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr18:9,212,856...9,216,201
Ensembl chr18:9,212,163...9,218,136
|
|
| G
|
G6pdx
|
glucose-6-phosphate dehydrogenase X-linked
|
increases expression decreases activity multiple interactions
|
ISO
|
lead acetate results in increased expression of G6PD mRNA lead acetate results in decreased activity of G6PD protein [naringenin co-treated with lead acetate] results in decreased activity of G6PD protein
|
CTD |
PMID:25228019 PMID:30980912 PMID:37939567 PMID:38568856 |
|
NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
|
|
| G
|
Gaa
|
glucosidase, alpha, acid
|
increases expression
|
ISO
|
lead acetate results in increased expression of GAA mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr11:119,158,789...119,176,284
Ensembl chr11:119,158,713...119,176,280
|
|
| G
|
Gab2
|
growth factor receptor bound protein 2-associated protein 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of GAB2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:96,730,958...96,958,158
Ensembl chr 7:96,730,793...96,958,153
|
|
| G
|
Gabarapl2
|
GABA type A receptor associated protein like 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of GABARAPL2 mRNA; [sodium arsenite co-treated with lead acetate] results in increased expression of GABARAPL2 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 8:112,667,335...112,679,547
Ensembl chr 8:112,667,335...112,680,244
|
|
| G
|
Gabrq
|
gamma-aminobutyric acid type A receptor subunit theta
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GABRQ mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr X:71,868,769...71,886,213
Ensembl chr X:71,868,784...71,886,208
|
|
| G
|
Gabrr1
|
gamma-aminobutyric acid type A receptor subunit rho 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GABRR1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 4:33,132,556...33,163,606
Ensembl chr 4:33,132,521...33,163,588
|
|
| G
|
Gad2
|
glutamic acid decarboxylase 2
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of GAD2 protein
|
CTD |
PMID:31785328 |
|
NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886
|
|
| G
|
Gadd45a
|
growth arrest and DNA-damage-inducible 45 alpha
|
increases expression
|
ISO
|
lead acetate results in increased expression of GADD45A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
|
|
| G
|
Gadd45g
|
growth arrest and DNA-damage-inducible 45 gamma
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of GADD45G gene
|
CTD |
PMID:29571894 |
|
NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504
|
|
| G
|
Galns
|
galactosamine (N-acetyl)-6-sulfatase
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GALNS mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:123,304,976...123,338,226
Ensembl chr 8:123,304,981...123,338,202
|
|
| G
|
Galnt15
|
polypeptide N-acetylgalactosaminyltransferase 15
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GALNT15 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:31,750,739...31,784,161
Ensembl chr14:31,750,946...31,784,154
|
|
| G
|
Galnt2
|
polypeptide N-acetylgalactosaminyltransferase 2
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased expression of GALNT2 mRNA; [lead acetate results in increased abundance of Lead] which results in increased methylation of GALNT2 intron; [lead acetate results in increased abundance of Lead] which results in increased methylation of GALNT2 promoter
|
CTD |
PMID:33445541 |
|
NCBI chr 8:124,958,133...125,072,461
Ensembl chr 8:124,958,130...125,072,463
|
|
| G
|
Galnt9
|
polypeptide N-acetylgalactosaminyltransferase 9
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of GALNT9 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 5:110,692,217...110,769,244
Ensembl chr 5:110,692,221...110,769,246
|
|
| G
|
Galr1
|
galanin receptor 1
|
decreases expression
|
ISO EXP
|
lead acetate results in decreased expression of GALR1 mRNA
|
CTD |
PMID:22609695 PMID:22641619 |
|
NCBI chr18:82,410,621...82,424,902
Ensembl chr18:82,410,505...82,424,902
|
|
| G
|
Galr2
|
galanin receptor 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of GALR2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:116,170,520...116,174,776
Ensembl chr11:116,171,765...116,174,764
|
|
| G
|
Gap43
|
growth associated protein 43
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] promotes the reaction [[APP protein co-treated with APP protein modified form] results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] which results in decreased expression of GAP43 protein
|
CTD |
PMID:31843630 |
|
NCBI chr16:42,068,915...42,161,014
Ensembl chr16:42,068,805...42,161,014
|
|
| G
|
Gapdh
|
glyceraldehyde-3-phosphate dehydrogenase
|
increases expression
|
EXP
|
lead acetate results in increased expression of GAPDH protein
|
CTD |
PMID:20797405 |
|
NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
|
|
| G
|
Gast
|
gastrin
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of GAST mRNA; lead acetate results in increased expression of GAST protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of GAST mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased expression of GAST mRNA]; RTKI cpd inhibits the reaction [lead acetate results in increased expression of GAST mRNA]
|
CTD |
PMID:23765435 |
|
NCBI chr11:100,225,233...100,227,823
Ensembl chr11:100,225,233...100,227,822
|
|
| G
|
Gata2
|
GATA binding protein 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GATA2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014
|
|
| G
|
Gata3
|
GATA binding protein 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GATA3 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845
|
|
| G
|
Gata6
|
GATA binding protein 6
|
multiple interactions increases expression
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GATA6 mRNA lead acetate results in increased expression of GATA6 mRNA
|
CTD |
PMID:12634122 PMID:38568856 |
|
NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635
|
|
| G
|
Gatm
|
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GATM mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:122,424,954...122,441,758
Ensembl chr 2:122,424,948...122,441,784
|
|
| G
|
Gbp2b
|
guanylate binding protein 2b
|
increases expression
|
ISO
|
lead acetate results in increased expression of GBP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940
|
|
| G
|
Gbp8
|
guanylate-binding protein 8
|
increases expression
|
EXP
|
lead acetate results in increased expression of GBP8 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:105,160,379...105,201,475
Ensembl chr 5:105,162,016...105,287,406
|
|
| G
|
Gbp9
|
guanylate-binding protein 9
|
increases expression
|
EXP
|
lead acetate results in increased expression of GBP6 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:105,224,331...105,258,255
Ensembl chr 5:105,225,496...105,287,405
|
|
| G
|
Gbx2
|
gastrulation brain homeobox 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GBX2 mRNA
|
CTD |
PMID:22613225 PMID:25270620 |
|
NCBI chr 1:89,855,684...89,858,898
Ensembl chr 1:89,855,678...89,858,901
|
|
| G
|
Gc
|
vitamin D binding protein
|
increases expression
|
ISO
|
lead acetate results in increased expression of GC mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757
|
|
| G
|
Gch1
|
GTP cyclohydrolase 1
|
decreases expression increases expression
|
ISO EXP
|
lead acetate results in decreased expression of GCH1 mRNA lead acetate results in increased expression of GCH1 mRNA
|
CTD |
PMID:22641619 PMID:25270620 |
|
NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870
|
|
| G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
multiple interactions increases expression
|
ISO
|
[[lead acetate results in increased abundance of Lead] which co-treated with Rutin] results in increased expression of GCLC mRNA; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GCLC mRNA] [lead acetate results in increased abundance of Lead] which results in increased expression of GCLC mRNA; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of GCLC mRNA; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of CDH1 mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of CDH1 protein]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ACTA2 mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of CDH2 protein]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of CHD2 mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of SNAI1 mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of SNAI1 protein]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of VIM mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of VIM protein]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ZEB1 mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ZEB1 protein]
|
CTD |
PMID:26498409 PMID:37939567 PMID:38568856 PMID:39032614 PMID:39276841 PMID:39722890 More...
|
|
NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
|
|
| G
|
Gclm
|
glutamate-cysteine ligase, modifier subunit
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of GCLM mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of GCLM mRNA NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GCLM mRNA]
|
CTD |
PMID:25270620 PMID:26498409 PMID:37939567 PMID:38568856 PMID:39276841 |
|
NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
|
|
| G
|
Gcnt1
|
glucosaminyl (N-acetyl) transferase 1, core 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of GCNT1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:17,303,505...17,350,208
Ensembl chr19:17,303,505...17,350,208
|
|
| G
|
Gcnt3
|
glucosaminyl (N-acetyl) transferase 3, mucin type
|
increases expression
|
EXP
|
lead acetate results in increased expression of GCNT3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:69,938,777...69,947,172
Ensembl chr 9:69,938,778...69,945,370
|
|
| G
|
Gcnt4
|
glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
|
increases expression
|
ISO
|
lead acetate results in increased expression of GCNT4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr13:97,060,852...97,087,422
Ensembl chr13:97,061,197...97,087,414
|
|
| G
|
Gdap2
|
ganglioside-induced differentiation-associated-protein 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GDAP2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:100,069,843...100,117,909
Ensembl chr 3:100,069,697...100,114,297
|
|
| G
|
Gdf15
|
growth differentiation factor 15
|
multiple interactions increases expression
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GDF15 mRNA lead acetate results in increased expression of GDF15 mRNA
|
CTD |
PMID:12634122 PMID:38568856 |
|
NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
|
|
| G
|
Gdf2
|
growth differentiation factor 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of GDF2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr14:33,662,996...33,669,155
Ensembl chr14:33,662,996...33,669,155
|
|
| G
|
Gdf5
|
growth differentiation factor 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of GDF5 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:155,782,943...155,787,204
Ensembl chr 2:155,782,943...155,787,287
|
|
| G
|
Gfap
|
glial fibrillary acidic protein
|
multiple interactions increases expression decreases expression
|
ISO EXP
|
[[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of and results in increased activity of PPARG protein] which results in decreased expression of GFAP protein; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in decreased expression of GFAP protein; [lead acetate co-treated with Morphine] results in increased expression of GFAP mRNA; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of GFAP protein; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] promotes the reaction [PPARG protein binds to GFAP promoter]; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of GFAP mRNA; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of GFAP protein; CR8 compound inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of GFAP protein] lead acetate results in increased expression of GFAP mRNA; lead acetate results in increased expression of GFAP protein lead acetate results in decreased expression of GFAP protein [lead acetate results in increased abundance of Lead] which results in increased expression of GFAP protein; pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in increased expression of GFAP mRNA] F2RL2 protein inhibits the reaction [lead acetate results in increased expression of GFAP mRNA]; PANX2 protein inhibits the reaction [lead acetate results in increased expression of GFAP mRNA]
|
CTD |
PMID:17047031 PMID:20829427 PMID:21322097 PMID:24481447 PMID:25028260 PMID:26396915 PMID:26478469 PMID:33862172 PMID:36539177 PMID:37939567 More...
|
|
NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
|
|
| G
|
Ggct
|
gamma-glutamyl cyclotransferase
|
increases expression
|
EXP
|
lead acetate results in increased expression of GGCT mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:54,962,080...54,969,947
Ensembl chr 6:54,959,565...54,969,935
|
|
| G
|
Ggh
|
gamma-glutamyl hydrolase
|
increases expression
|
ISO
|
lead acetate results in increased expression of GGH mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:20,041,963...20,066,111
Ensembl chr 4:20,042,052...20,066,750
|
|
| G
|
Ggt5
|
gamma-glutamyltransferase 5
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GGT5 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:75,425,161...75,453,034
Ensembl chr10:75,425,174...75,453,034
|
|
| G
|
Ghitm
|
growth hormone inducible transmembrane protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of GHITM mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr14:36,842,401...36,857,279
Ensembl chr14:36,842,049...36,857,229
|
|
| G
|
Gimap7
|
GTPase, IMAP family member 7
|
increases expression
|
EXP
|
lead acetate results in increased expression of GIMAP7 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:48,695,555...48,701,570
Ensembl chr 6:48,695,555...48,701,570
|
|
| G
|
Gja1
|
gap junction protein, alpha 1
|
increases expression increases uptake decreases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of GJA1 protein GJA1 protein results in increased uptake of lead acetate lead acetate results in decreased expression of GJA1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of GJA1 protein]; 3-methyladenine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GJA1 protein]; [lead acetate results in increased abundance of Lead] which results in decreased expression of and affects the localization of GJA1 protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of GJA1 protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of GJA1 mRNA; Dasatinib promotes the reaction [lead acetate results in decreased expression of GJA1 protein]; GJA1 protein inhibits the reaction [Carbenoxolone results in decreased uptake of lead acetate]; Nimodipine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of GJA1 protein]; Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of GJA1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of GJA1 protein]
|
CTD |
PMID:20932874 PMID:26926986 PMID:28916327 PMID:29457680 PMID:33242459 PMID:36925031 More...
|
|
NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
|
|
| G
|
Gja8
|
gap junction protein, alpha 8
|
increases expression
|
EXP
|
lead acetate results in increased expression of GJA8 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:96,820,882...96,833,367
Ensembl chr 3:96,820,882...96,833,336
|
|
| G
|
Gjb6
|
gap junction protein, beta 6
|
increases expression
|
ISO
|
lead acetate results in increased expression of GJB6 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:57,360,760...57,370,764
Ensembl chr14:57,360,760...57,371,068
|
|
| G
|
Gjc2
|
gap junction protein, gamma 2
|
increases expression
|
ISO EXP
|
lead acetate results in increased expression of GJC2 mRNA
|
CTD |
PMID:22609695 PMID:22641619 |
|
NCBI chr11:59,066,390...59,074,039
Ensembl chr11:59,066,394...59,074,039
|
|
| G
|
Gjc3
|
gap junction protein, gamma 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of GJC3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:137,949,254...137,961,360
Ensembl chr 5:137,951,723...137,961,360
|
|
| G
|
Gk
|
glycerol kinase
|
increases expression
|
ISO
|
lead acetate results in increased expression of GK mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr X:84,745,543...84,820,425
Ensembl chr X:84,745,543...84,820,425
|
|
| G
|
Gldn
|
gliomedin
|
increases expression
|
ISO
|
lead acetate results in increased expression of GLDN mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:54,193,770...54,249,061
Ensembl chr 9:54,193,770...54,249,070
|
|
| G
|
Gli1
|
GLI-Kruppel family member GLI1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843
|
|
| G
|
Glipr1
|
GLI pathogenesis related 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of GLIPR1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:111,821,353...111,838,539
Ensembl chr10:111,821,353...111,838,536
|
|
| G
|
Glipr2
|
GLI pathogenesis-related 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of GLIPR2 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 4:43,957,702...43,979,118
Ensembl chr 4:43,957,401...43,979,118
|
|
| G
|
Glod4
|
glyoxalase domain containing 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of GLOD4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:76,111,221...76,134,525
Ensembl chr11:76,011,813...76,134,551
|
|
| G
|
Glra2
|
glycine receptor, alpha 2 subunit
|
decreases expression
|
ISO EXP
|
lead acetate results in decreased expression of GLRA2 mRNA
|
CTD |
PMID:22613225 PMID:22641619 |
|
NCBI chr X:163,912,013...164,110,863
Ensembl chr X:163,912,013...164,110,389
|
|
| G
|
Glra3
|
glycine receptor, alpha 3 subunit
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GLRA3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 8:56,393,454...56,583,111
Ensembl chr 8:56,393,495...56,583,105
|
|
| G
|
Glrp1
|
glutamine repeat protein 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of GLRP1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 1:88,427,593...88,437,788
Ensembl chr 1:88,427,593...88,437,788
|
|
| G
|
Glt28d2
|
glycosyltransferase 28 domain containing 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GLT28D2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:85,777,153...85,794,825
Ensembl chr 3:85,777,156...85,794,823
|
|
| G
|
Glud1
|
glutamate dehydrogenase 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GLUD1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222
|
|
| G
|
Glul
|
glutamate-ammonia ligase
|
decreases expression increases expression multiple interactions
|
ISO EXP
|
lead acetate results in decreased expression of GLUL mRNA lead acetate results in increased expression of GLUL mRNA [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of GLUL protein
|
CTD |
PMID:20542052 PMID:23680456 PMID:25270620 PMID:38568856 |
|
NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469
|
|
| G
|
Gm3764
|
predicted gene 3764
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MIR9-1HG mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 3:88,113,980...88,137,266
Ensembl chr 3:88,113,033...88,137,271
|
|
| G
|
Gm4553
|
predicted gene 4553
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of KRTAP5-4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:141,718,433...141,719,488
Ensembl chr 7:141,718,433...141,719,476
|
|
| G
|
Gm9920
|
predicted gene 9920
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of FAM106A mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr15:54,963,313...54,976,978
Ensembl chr15:54,963,313...54,977,100
|
|
| G
|
Gmnn
|
geminin
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GMNN mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr13:24,935,828...24,954,222
Ensembl chr13:24,935,828...24,945,906
|
|
| G
|
Gna13
|
guanine nucleotide binding protein, alpha 13
|
increases expression
|
EXP
|
lead acetate results in increased expression of GNA13 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:109,253,620...109,292,195
Ensembl chr11:109,253,657...109,292,195
|
|
| G
|
Gnao1
|
guanine nucleotide binding protein, alpha O
|
increases expression
|
EXP
|
lead acetate results in increased expression of GNAO1 protein
|
CTD |
PMID:20797405 |
|
NCBI chr 8:94,537,213...94,696,016
Ensembl chr 8:94,536,594...94,696,016
|
|
| G
|
Gnb4
|
guanine nucleotide binding protein (G protein), beta 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of GNB4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:32,632,736...32,670,813
Ensembl chr 3:32,634,481...32,670,734
|
|
| G
|
Gng11
|
guanine nucleotide binding protein (G protein), gamma 11
|
increases expression
|
ISO
|
lead acetate results in increased expression of GNG11 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:4,003,987...4,008,445
Ensembl chr 6:4,003,904...4,008,445
|
|
| G
|
Gng12
|
guanine nucleotide binding protein (G protein), gamma 12
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GNG12 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 6:66,873,381...66,998,345
Ensembl chr 6:66,873,381...66,998,334
|
|
| G
|
Gng5
|
G protein subunit gamma 5
|
increases expression
|
ISO
|
lead acetate results in increased expression of GNG5 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:146,205,591...146,211,298
Ensembl chr 3:146,205,562...146,211,327
|
|
| G
|
Gngt2
|
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GNGT2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:95,733,045...95,736,557
Ensembl chr11:95,728,042...95,736,560
|
|
| G
|
Golph3
|
golgi phosphoprotein 3
|
decreases expression increases methylation
|
ISO
|
lead acetate results in decreased expression of GOLPH3 mRNA lead acetate results in increased methylation of GOLPH3 gene
|
CTD |
PMID:29571894 |
|
NCBI chr15:12,319,617...12,351,687
Ensembl chr15:12,321,536...12,351,677
|
|
| G
|
Gosr2
|
golgi SNAP receptor complex member 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of GOSR2 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr11:103,567,675...103,590,139
Ensembl chr11:103,567,675...103,588,724
|
|
| G
|
Got1
|
glutamic-oxaloacetic transaminase 1, soluble
|
multiple interactions increases expression
|
EXP
|
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GOT1 protein]
|
CTD |
PMID:22033380 |
|
NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044
|
|
| G
|
Got2
|
glutamatic-oxaloacetic transaminase 2, mitochondrial
|
increases expression
|
ISO
|
lead acetate results in increased expression of GOT2 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175
|
|
| G
|
Gpat3
|
glycerol-3-phosphate acyltransferase 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of GPAT3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:100,994,095...101,046,968
Ensembl chr 5:100,993,579...101,046,968
|
|
| G
|
Gpat4
|
glycerol-3-phosphate acyltransferase 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of GPAT4 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 8:23,661,281...23,698,469
Ensembl chr 8:23,661,281...23,698,362
|
|
| G
|
Gpatch4
|
G patch domain containing 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of GPATCH4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:87,950,413...87,963,301
Ensembl chr 3:87,950,415...87,963,300
|
|
| G
|
Gpc1
|
glypican 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of GPC1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:92,759,367...92,787,933
Ensembl chr 1:92,759,367...92,788,501
|
|
| G
|
Gpd1
|
glycerol-3-phosphate dehydrogenase 1 (soluble)
|
increases expression
|
ISO
|
lead acetate results in increased expression of GPD1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr15:99,615,468...99,622,895
Ensembl chr15:99,615,396...99,622,886
|
|
| G
|
Gpd1l
|
glycerol-3-phosphate dehydrogenase 1-like
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GPD1L mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:114,728,407...114,763,055
Ensembl chr 9:114,728,409...114,763,055
|
|
| G
|
Gpm6b
|
glycoprotein m6b
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GPM6B mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr X:165,021,911...165,172,028
Ensembl chr X:165,021,907...165,171,984
|
|
| G
|
Gpr132
|
G protein-coupled receptor 132
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of GPR132 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr12:112,814,493...112,832,035
Ensembl chr12:112,814,493...112,831,848
|
|
| G
|
Gpr139
|
G protein-coupled receptor 139
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GPR139 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:118,739,970...118,783,761
Ensembl chr 7:118,739,970...118,783,826
|
|
| G
|
Gpr155
|
G protein-coupled receptor 155
|
increases expression
|
EXP
|
lead acetate results in increased expression of GPR155 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:73,171,850...73,216,842
Ensembl chr 2:73,171,850...73,216,916
|
|
| G
|
Gpr183
|
G protein-coupled receptor 183
|
increases expression
|
ISO
|
lead acetate results in increased expression of GPR183 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:122,189,743...122,202,605
Ensembl chr14:122,189,963...122,202,607
|
|
| G
|
Gprasp1
|
G protein-coupled receptor associated sorting protein 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of GPRASP1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr X:134,643,441...134,704,217
Ensembl chr X:134,643,482...134,704,223
|
|
| G
|
Gprc5a
|
G protein-coupled receptor, family C, group 5, member A
|
increases expression
|
ISO
|
lead acetate results in increased expression of GPRC5A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:135,042,660...135,061,707
Ensembl chr 6:135,042,649...135,061,707
|
|
| G
|
Gprin1
|
G protein-regulated inducer of neurite outgrowth 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of GPRIN1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:54,884,484...54,897,486
Ensembl chr13:54,884,484...54,897,687
|
|
| G
|
Gpt
|
glutamic pyruvic transaminase, soluble
|
increases expression multiple interactions
|
EXP
|
lead acetate results in increased expression of GPT protein [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of GPT protein; [lead acetate results in increased abundance of Lead] which results in increased expression of GPT protein; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased expression of GPT protein]
|
CTD |
PMID:22033380 PMID:38180308 |
|
NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
|
|
| G
|
Gpx1
|
glutathione peroxidase 1
|
decreases expression multiple interactions increases expression
|
ISO EXP
|
lead acetate results in decreased expression of GPX1 mRNA; lead acetate results in decreased expression of GPX1 protein 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in decreased expression of GPX1 mRNA]; [Cadmium Chloride co-treated with lead acetate co-treated with manganese chloride] results in increased activity of GPX1 protein; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GPX1 mRNA]; sinapinic acid inhibits the reaction [lead acetate results in decreased expression of GPX1 protein] lead acetate results in increased expression of GPX1 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA]
|
CTD |
PMID:15014207 PMID:22197700 PMID:27599793 PMID:29746905 PMID:30623991 PMID:31610155 PMID:32116774 PMID:32208856 PMID:33862172 PMID:38530053 More...
|
|
NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
|
|
| G
|
Gpx4
|
glutathione peroxidase 4
|
decreases expression multiple interactions affects expression
|
ISO
|
lead acetate results in decreased expression of GPX4 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of GPX4 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of GPX4 protein; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX4 mRNA]; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX4 mRNA]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX4 protein] lead acetate affects the expression of GPX4 mRNA
|
CTD |
PMID:15014207 PMID:33862172 PMID:36642386 PMID:39276841 |
|
NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
|
|
| G
|
Gramd1b
|
GRAM domain containing 1B
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GRAMD1B mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 9:40,204,529...40,443,656
Ensembl chr 9:40,204,529...40,442,679
|
|
| G
|
Gramd2a
|
GRAM domain containing 2A
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GRAMD2A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:59,587,116...59,626,156
Ensembl chr 9:59,587,427...59,626,157
|
|
| G
|
Grb10
|
growth factor receptor bound protein 10
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of GRB10 mRNA [sodium arsenite co-treated with lead acetate] results in decreased expression of GRB10 protein
|
CTD |
PMID:25270620 PMID:38072110 |
|
NCBI chr11:11,880,499...11,987,428
Ensembl chr11:11,880,508...11,988,683
|
|
| G
|
Grb7
|
growth factor receptor bound protein 7
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GRB7 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:98,337,660...98,346,199
Ensembl chr11:98,337,220...98,346,199
|
|
| G
|
Greb1
|
gene regulated by estrogen in breast cancer protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of GREB1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr12:16,720,616...16,851,395
Ensembl chr12:16,720,616...16,850,887
|
|
| G
|
Grem1
|
gremlin 1, DAN family BMP antagonist
|
increases expression
|
ISO
|
lead acetate results in increased expression of GREM1 mRNA
|
CTD |
PMID:27562236 |
|
NCBI chr 2:113,579,020...113,588,993
Ensembl chr 2:113,576,509...113,588,991
|
|
| G
|
Grhl3
|
grainyhead like transcription factor 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GRHL3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:135,269,199...135,300,943
Ensembl chr 4:135,269,199...135,300,941
|
|
| G
|
Gria1
|
glutamate receptor, ionotropic, AMPA1 (alpha 1)
|
affects expression
|
EXP
|
lead acetate affects the expression of GRIA1 mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070
|
|
| G
|
Gria2
|
glutamate receptor, ionotropic, AMPA2 (alpha 2)
|
decreases expression
|
EXP ISO
|
lead acetate results in decreased expression of GRIA2 mRNA
|
CTD |
PMID:24260418 PMID:33862172 |
|
NCBI chr 3:80,588,757...80,711,534
Ensembl chr 3:80,588,757...80,710,142
|
|
| G
|
Gria3
|
glutamate receptor, ionotropic, AMPA3 (alpha 3)
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of GRIA3 mRNA lead acetate results in increased expression of GRIA3 mRNA
|
CTD |
PMID:24260418 PMID:33862172 |
|
NCBI chr X:40,489,351...40,767,478
Ensembl chr X:40,489,731...40,767,478
|
|
| G
|
Gria4
|
glutamate receptor, ionotropic, AMPA4 (alpha 4)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GRIA4 mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 9:4,417,893...4,796,250
Ensembl chr 9:4,417,896...4,796,234
|
|
| G
|
Grik1
|
glutamate receptor, ionotropic, kainate 1
|
decreases expression increases expression
|
EXP
|
lead acetate results in decreased expression of GRIK1 mRNA lead acetate results in increased expression of GRIK1 mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr16:87,692,789...88,087,751
Ensembl chr16:87,692,788...88,087,153
|
|
| G
|
Grik2
|
glutamate receptor, ionotropic, kainate 2 (beta 2)
|
multiple interactions increases expression
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of GRIK2 intron lead acetate results in increased expression of GRIK2 mRNA
|
CTD |
PMID:24260418 PMID:33445541 |
|
NCBI chr10:48,969,776...49,666,523
Ensembl chr10:48,970,929...49,664,862
|
|
| G
|
Grik3
|
glutamate receptor, ionotropic, kainate 3
|
affects expression
|
EXP
|
lead acetate affects the expression of GRIK3 mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 4:125,384,025...125,607,966
Ensembl chr 4:125,384,493...125,607,966
|
|
| G
|
Grik5
|
glutamate receptor, ionotropic, kainate 5 (gamma 2)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GRIK5 mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 7:24,709,274...24,775,421
Ensembl chr 7:24,709,274...24,771,771
|
|
| G
|
Grin1
|
glutamate receptor, ionotropic, NMDA1 (zeta 1)
|
multiple interactions decreases expression
|
ISO EXP
|
[lead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein]] which results in decreased phosphorylation of CREB1 protein; Choline analog inhibits the reaction [lead acetate results in decreased expression of GRIN1 mRNA]; Choline analog inhibits the reaction [lead acetate results in decreased expression of GRIN1 protein]; lead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein] lead acetate results in decreased expression of GRIN1 mRNA; lead acetate results in decreased expression of GRIN1 protein
|
CTD |
PMID:12480136 PMID:20381573 PMID:22160880 PMID:24260418 PMID:25242007 |
|
NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
|
|
| G
|
Grin2a
|
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
|
multiple interactions affects expression decreases expression increases expression
|
ISO EXP
|
Choline analog affects the reaction [lead acetate results in decreased expression of GRIN2A mRNA] lead acetate affects the expression of GRIN2A mRNA lead acetate results in decreased expression of GRIN2A mRNA; lead acetate results in decreased expression of GRIN2A protein lead acetate results in increased expression of GRIN2A mRNA
|
CTD |
PMID:15973774 PMID:20381573 PMID:22160880 PMID:22362014 PMID:24260418 PMID:25496357 More...
|
|
NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424
|
|
| G
|
Grin2b
|
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
|
multiple interactions decreases expression increases expression
|
ISO EXP
|
[lead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein]] which results in decreased phosphorylation of CREB1 protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of GRIN2B protein; asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GRIN2B protein]; Choline analog affects the reaction [lead acetate results in decreased expression of GRIN2B mRNA]; lead acetate promotes the reaction [GRIN1 protein binds to GRIN2B protein] lead acetate results in decreased expression of GRIN2B mRNA; lead acetate results in decreased expression of GRIN2B protein lead acetate results in increased expression of GRIN2B mRNA
|
CTD |
PMID:12480136 PMID:20381573 PMID:22160880 PMID:22362014 PMID:24260418 PMID:25242007 PMID:25496357 PMID:27936013 More...
|
|
NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
|
|
| G
|
Grin2c
|
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
|
increases expression
|
EXP
|
lead acetate results in increased expression of GRIN2C mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr11:115,139,995...115,158,123
Ensembl chr11:115,139,995...115,158,069
|
|
| G
|
Grin2d
|
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of GRIN2D mRNA lead acetate results in decreased expression of GRIN2D mRNA
|
CTD |
PMID:24260418 PMID:33862172 |
|
NCBI chr 7:45,481,307...45,520,708
Ensembl chr 7:45,481,307...45,527,802
|
|
| G
|
Grin3a
|
glutamate receptor ionotropic, NMDA3A
|
increases expression
|
EXP
|
lead acetate results in increased expression of GRIN3A mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 4:49,661,611...49,846,023
Ensembl chr 4:49,661,611...49,845,744
|
|
| G
|
Grin3b
|
glutamate receptor, ionotropic, NMDA3B
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of GRIN3B mRNA
|
CTD |
PMID:22160880 PMID:24260418 |
|
NCBI chr10:79,806,227...79,813,024
Ensembl chr10:79,806,549...79,813,024
|
|
| G
|
Grip1
|
glutamate receptor interacting protein 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GRIP1 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr10:119,289,810...119,923,172
Ensembl chr10:119,289,735...119,923,166
|
|
| G
|
Grk1
|
G protein-coupled receptor kinase 1
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of GRK1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 8:13,455,081...13,471,951
Ensembl chr 8:13,455,081...13,471,951
|
|
| G
|
Grk3
|
G protein-coupled receptor kinase 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of GRK3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:113,058,344...113,163,518
Ensembl chr 5:113,058,348...113,163,657
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| G
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Grk5
|
G protein-coupled receptor kinase 5
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increases expression multiple interactions
|
ISO EXP
|
lead acetate results in increased expression of GRK5 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of GRK5 mRNA
|
CTD |
PMID:11578147 PMID:33445541 |
|
NCBI chr19:60,877,995...61,084,406
Ensembl chr19:60,878,187...61,084,406
|
|
| G
|
Grm1
|
glutamate receptor, metabotropic 1
|
decreases expression affects expression
|
EXP ISO
|
lead acetate results in decreased expression of GRM1 mRNA lead acetate affects the expression of GRM1 mRNA
|
CTD |
PMID:22362014 PMID:24260418 |
|
NCBI chr10:10,561,803...10,958,126
Ensembl chr10:10,561,803...10,958,100
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|
| G
|
Grm4
|
glutamate receptor, metabotropic 4
|
increases expression affects expression
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EXP ISO
|
lead acetate results in increased expression of GRM4 mRNA lead acetate affects the expression of GRM4 mRNA
|
CTD |
PMID:22160880 PMID:24260418 |
|
NCBI chr17:27,641,361...27,732,800
Ensembl chr17:27,641,361...27,740,377
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|
| G
|
Grm5
|
glutamate receptor, metabotropic 5
|
affects expression
|
ISO
|
lead acetate affects the expression of GRM5 mRNA
|
CTD |
PMID:22160880 |
|
NCBI chr 7:87,233,212...87,784,271
Ensembl chr 7:87,233,376...87,784,115
|
|
| G
|
Grm6
|
glutamate receptor, metabotropic 6
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decreases expression increases expression
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EXP
|
lead acetate results in decreased expression of GRM6 mRNA lead acetate results in increased expression of GRM6 mRNA
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CTD |
PMID:24260418 |
|
NCBI chr11:50,741,205...50,757,035
Ensembl chr11:50,741,512...50,757,035
|
|
| G
|
Grm8
|
glutamate receptor, metabotropic 8
|
increases expression
|
EXP
|
lead acetate results in increased expression of GRM8 mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 6:27,275,120...28,135,094
Ensembl chr 6:27,275,118...28,135,177
|
|
| G
|
Grn
|
granulin
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increases expression affects expression
|
EXP ISO
|
lead acetate results in increased expression of GRN mRNA lead acetate affects the expression of GRN protein
|
CTD |
PMID:21829687 PMID:36539177 |
|
NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874
|
|
| G
|
Gsk3a
|
glycogen synthase kinase 3 alpha
|
decreases methylation increases expression
|
ISO
|
lead acetate results in decreased methylation of GSK3A gene lead acetate results in increased expression of GSK3A mRNA
|
CTD |
PMID:29571894 PMID:38568856 |
|
NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276
|
|
| G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
increases phosphorylation increases expression multiple interactions
|
ISO EXP
|
lead acetate results in increased phosphorylation of GSK3B protein lead acetate results in increased expression of GSK3B mRNA lead acetate results in increased expression of GSK3B protein 3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in increased expression of GSK3B protein]; [lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein
|
CTD |
PMID:27012722 PMID:37385299 PMID:37436718 PMID:38568856 |
|
NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
|
|
| G
|
Gsr
|
glutathione reductase
|
decreases expression increases activity multiple interactions affects activity decreases activity increases expression
|
ISO EXP
|
lead acetate results in decreased expression of GSR mRNA; lead acetate results in decreased expression of GSR protein lead acetate results in increased activity of GSR protein 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in decreased expression of GSR mRNA]; [lead acetate results in increased abundance of Lead] which results in decreased activity of GSR protein; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased activity of GSR protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of GSR mRNA]; ferulic acid inhibits the reaction [lead acetate results in increased activity of GSR protein]; lead acetate promotes the reaction [sodium arsenite results in decreased activity of GSR protein]; sodium arsenite promotes the reaction [lead acetate results in decreased activity of GSR protein] lead acetate affects the activity of GSR protein lead acetate results in increased expression of GSR mRNA
|
CTD |
PMID:19263481 PMID:22197700 PMID:25322819 PMID:28817314 PMID:30510688 PMID:30623991 PMID:32116774 PMID:32208856 PMID:32407874 More...
|
|
NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
|
|
| G
|
Gss
|
glutathione synthetase
|
increases expression
|
EXP
|
lead acetate results in increased expression of GSS mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730
|
|
| G
|
Gsta1
|
glutathione S-transferase, alpha 1 (Ya)
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of GSTA5 mRNA lead acetate results in increased expression of GSTA5 mRNA
|
CTD |
PMID:33862172 |
|
NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966
|
|
| G
|
Gsta2
|
glutathione S-transferase, alpha 2 (Yc2)
|
increases expression
|
ISO
|
lead acetate results in increased expression of GSTA2 protein
|
CTD |
PMID:9750042 |
|
NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070
|
|
| G
|
Gsta4
|
glutathione S-transferase, alpha 4
|
affects expression increases expression
|
ISO
|
lead acetate affects the expression of GSTA4 mRNA lead acetate results in increased expression of GSTA4 protein
|
CTD |
PMID:7878682 PMID:9750042 PMID:21864555 |
|
NCBI chr 9:78,099,248...78,116,631
Ensembl chr 9:78,090,056...78,116,631
|
|
| G
|
Gstk1
|
glutathione S-transferase kappa 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of GSTK1 mRNA
|
CTD |
PMID:29746905 |
|
NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381
|
|
| G
|
Gstm1
|
glutathione S-transferase, mu 1
|
affects localization increases expression
|
ISO
|
lead acetate affects the localization of GSTM1 protein lead acetate results in increased expression of GSTM1 mRNA; lead acetate results in increased expression of GSTM1 protein
|
CTD |
PMID:7878682 PMID:9750042 |
|
NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
|
|
| G
|
Gstm2
|
glutathione S-transferase, mu 2
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of GSTM2 protein lead acetate results in increased expression of GSTM2 protein
|
CTD |
PMID:9750042 |
|
NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769
|
|
| G
|
Gsto1
|
glutathione S-transferase omega 1
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of GSTO1 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of GSTO1 mRNA; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GSTO1 mRNA]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GSTO1 mRNA]
|
CTD |
PMID:11578147 PMID:31610155 |
|
NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229
|
|
| G
|
Gstp1
|
glutathione S-transferase, pi 1
|
affects localization increases expression
|
ISO EXP
|
lead acetate affects the localization of GSTP1 protein lead acetate results in increased expression of GSTP1 mRNA lead acetate results in increased expression of GSTP1 mRNA; lead acetate results in increased expression of GSTP1 protein
|
CTD |
PMID:7878682 PMID:9750042 PMID:29746905 |
|
NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
|
|
| G
|
Gstt2
|
glutathione S-transferase, theta 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of GSTT2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr10:75,667,676...75,673,253
Ensembl chr10:75,666,948...75,673,258
|
|
| G
|
Gstz1
|
glutathione transferase zeta 1 (maleylacetoacetate isomerase)
|
affects expression
|
ISO
|
lead acetate affects the expression of GSTZ1 protein
|
CTD |
PMID:36539177 |
|
NCBI chr12:87,192,102...87,211,497
Ensembl chr12:87,193,939...87,211,497
|
|
| G
|
Gtf2a2
|
general transcription factor II A, 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GTF2A2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:69,919,830...69,930,148
Ensembl chr 9:69,919,832...69,930,148
|
|
| G
|
Gtf2f1
|
general transcription factor IIF, polypeptide 1
|
affects expression
|
ISO
|
lead acetate affects the expression of GTF2F1 protein
|
CTD |
PMID:36539177 |
|
NCBI chr17:57,310,402...57,318,398
Ensembl chr17:57,310,405...57,318,288
|
|
| G
|
Gtf3c5
|
general transcription factor IIIC, polypeptide 5
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of GTF3C5 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 2:28,456,257...28,473,291
Ensembl chr 2:28,456,323...28,473,763
|
|
| G
|
Guca1a
|
guanylate cyclase activator 1a (retina)
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GUCA1A mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr17:47,705,482...47,724,439
Ensembl chr17:47,705,483...47,711,509
|
|
| G
|
Guca1b
|
guanylate cyclase activator 1B
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GUCA1B mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr17:47,692,526...47,703,892
Ensembl chr17:47,696,318...47,703,892
|
|
| G
|
Gucy1a1
|
guanylate cyclase 1, soluble, alpha 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GUCY1A1 mRNA
|
CTD |
PMID:11729227 |
|
NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096
|
|
| G
|
Gucy1b1
|
guanylate cyclase 1, soluble, beta 1
|
multiple interactions decreases expression
|
ISO
|
Ascorbic Acid inhibits the reaction [lead acetate results in decreased expression of GUCY1B1 protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [lead acetate results in decreased expression of GUCY1B1 protein] lead acetate results in decreased expression of GUCY1B1 mRNA; lead acetate results in decreased expression of GUCY1B1 protein
|
CTD |
PMID:11729227 PMID:16395254 |
|
NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996
|
|
| G
|
Gulp1
|
GULP, engulfment adaptor PTB domain containing 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of GULP1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:44,590,540...44,835,998
Ensembl chr 1:44,590,671...44,835,998
|
|
| G
|
Gys1
|
glycogen synthase 1, muscle
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of GYS1 mRNA lead acetate results in decreased expression of GYS1 mRNA; lead acetate results in decreased expression of GYS1 protein
|
CTD |
PMID:25270620 PMID:28916327 |
|
NCBI chr 7:45,084,263...45,106,041
Ensembl chr 7:45,084,268...45,106,043
|
|
| G
|
Gzmd
|
granzyme D
|
increases expression
|
EXP
|
lead acetate results in increased expression of GZMD mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr14:56,367,013...56,370,060
Ensembl chr14:56,367,013...56,370,065
|
|
| G
|
H1f10
|
H1.10 linker histone
|
increases expression
|
ISO
|
lead acetate results in increased expression of H1-10 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:87,957,403...87,958,464
Ensembl chr 6:87,957,403...87,958,619
|
|
| G
|
H2-Aa
|
histocompatibility 2, class II antigen A, alpha
|
increases expression
|
EXP
|
lead acetate results in increased expression of H2-AA mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
|
|
| G
|
H2-Ab1
|
histocompatibility 2, class II antigen A, beta 1
|
affects expression
|
EXP
|
lead acetate affects the expression of H2-AB1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393
|
|
| G
|
H2-DMb1
|
histocompatibility 2, class II, locus Mb1
|
increases expression
|
EXP
|
lead acetate results in increased expression of H2-DMB1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr17:34,372,165...34,379,203
Ensembl chr17:34,372,046...34,379,204
|
|
| G
|
H2-Ea
|
histocompatibility 2, class II antigen E alpha
|
increases expression decreases expression
|
ISO EXP
|
lead acetate results in increased expression of RT1-DA mRNA lead acetate results in decreased expression of H2-EA mRNA
|
CTD |
PMID:22609695 PMID:22641619 |
|
NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618
|
|
| G
|
H2-K1
|
histocompatibility 2, K1, K region
|
increases expression
|
EXP
|
lead acetate results in increased expression of H2-K1 mRNA
|
CTD |
PMID:20542052 PMID:22609695 |
|
NCBI chr17:34,214,986...34,219,316
Ensembl chr17:34,214,991...34,219,321
|
|
| G
|
H2-Oa
|
histocompatibility 2, O region alpha locus
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of H2-OA mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:34,311,353...34,314,286
Ensembl chr17:34,311,314...34,314,208
|
|
| G
|
H2-Q1
|
histocompatibility 2, Q region locus 1
|
decreases expression affects expression
|
EXP ISO
|
lead acetate results in decreased expression of H2-Q1 mRNA lead acetate affects the expression of RT1-CE16 mRNA
|
CTD |
PMID:22613225 PMID:22641619 |
|
NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075
|
|
| G
|
H2-Q4
|
histocompatibility 2, Q region locus 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of H2-Q4 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr17:35,598,593...35,603,650
Ensembl chr17:35,598,593...35,604,266
|
|
| G
|
H2ac1
|
H2A clustered histone 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of H2AC1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr13:24,118,420...24,118,896
Ensembl chr13:24,118,445...24,118,834
|
|
| G
|
H2ax
|
H2A.X variant histone
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein]
|
CTD |
PMID:31874198 |
|
NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
|
|
| G
|
H3f3b
|
H3.3 histone B
|
increases expression
|
EXP
|
lead acetate results in increased expression of H3F3B mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:115,912,787...115,921,313
Ensembl chr11:115,912,738...115,918,788 Ensembl chr11:115,912,738...115,918,788
|
|
| G
|
H4c14
|
H4 clustered histone 14
|
increases expression
|
ISO
|
lead acetate results in increased expression of H4C3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:96,170,250...96,170,633
Ensembl chr 3:96,168,998...96,170,627
|
|
| G
|
Hacd4
|
3-hydroxyacyl-CoA dehydratase 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of HACD4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 4:88,325,924...88,357,175
Ensembl chr 4:88,314,381...88,357,165
|
|
| G
|
Hamp
|
hepcidin antimicrobial peptide
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of HAMP mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
|
|
| G
|
Hap1
|
huntingtin-associated protein 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of HAP1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of HAP1 protein; REST protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of HAP1 mRNA]; REST protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of HAP1 protein]
|
CTD |
PMID:30742882 |
|
NCBI chr11:100,238,153...100,247,808
Ensembl chr11:100,238,153...100,246,954
|
|
| G
|
Hapln2
|
hyaluronan and proteoglycan link protein 2
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased expression of HAPLN2 mRNA
|
CTD |
PMID:32458983 |
|
NCBI chr 3:87,927,865...87,934,818
Ensembl chr 3:87,929,057...87,934,890
|
|
| G
|
Haus2
|
HAUS augmin-like complex, subunit 2
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of HAUS2 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 2:120,439,863...120,452,041
Ensembl chr 2:120,439,864...120,452,041
|
|
| G
|
Havcr1
|
hepatitis A virus cellular receptor 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of HAVCR1 protein
|
CTD |
PMID:34350654 |
|
NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
|
|
| G
|
Hbb-b1
|
hemoglobin, beta adult major chain
|
increases expression affects expression
|
EXP ISO
|
lead acetate results in increased expression of HBB-B1 mRNA lead acetate affects the expression of HBB-B1 mRNA lead acetate results in increased expression of HBB mRNA
|
CTD |
PMID:22609695 PMID:22641619 |
|
|
|
| G
|
Hbb-bh1
|
hemoglobin Z, beta-like embryonic chain
|
increases expression
|
EXP
|
lead acetate results in increased expression of HBB-BH1 mRNA
|
CTD |
PMID:21829687 PMID:22609695 |
|
NCBI chr 7:103,490,845...103,492,369
Ensembl chr 7:103,490,844...103,492,371
|
|
| G
|
Hbb-bs
|
hemoglobin, beta adult s chain
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of HBB-BS mRNA
|
CTD |
PMID:32458983 |
|
NCBI chr 7:103,475,730...103,477,135
Ensembl chr 7:103,475,741...103,477,303
|
|
| G
|
Hbegf
|
heparin-binding EGF-like growth factor
|
increases expression
|
ISO
|
lead acetate results in increased expression of HBEGF mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858
|
|
| G
|
Hcfc1
|
host cell factor C1
|
increases expression
|
ISO
|
lead acetate results in increased expression of HCFC1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr X:72,986,400...73,011,430
Ensembl chr X:72,986,398...73,009,963
|
|
| G
|
Hck
|
hemopoietic cell kinase
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 2:152,950,388...152,993,361
Ensembl chr 2:152,950,388...152,993,361
|
|
| G
|
Hdac2
|
histone deacetylase 2
|
multiple interactions increases expression
|
EXP
|
HDAC2 protein promotes the reaction [lead acetate results in decreased expression of CKM mRNA]; HDAC2 protein promotes the reaction [lead acetate results in decreased expression of CKM protein]; HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYH4 mRNA]; HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYH4 protein]; HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYOD1 mRNA]; HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYOD1 protein]; HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYOG mRNA]; HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYOG protein] lead acetate results in increased expression of HDAC2 protein
|
CTD |
PMID:37797690 |
|
NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885
|
|
| G
|
Hdac4
|
histone deacetylase 4
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of and affects the localization of HDAC4 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of HDAC4 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of HDAC4 protein; PPP1R12A protein affects the reaction [[lead acetate results in increased abundance of Lead] which affects the localization of HDAC4 protein]
|
CTD |
PMID:33080273 |
|
NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421
|
|
| G
|
Hdac7
|
histone deacetylase 7
|
increases expression multiple interactions
|
EXP
|
lead acetate results in increased expression of HDAC7 mRNA [lead acetate results in increased abundance of Lead] which results in increased methylation of HDAC7 promoter
|
CTD |
PMID:20542052 PMID:33445541 |
|
NCBI chr15:97,690,542...97,742,383
Ensembl chr15:97,690,545...97,742,383
|
|
| G
|
Hdac9
|
histone deacetylase 9
|
increases expression
|
EXP
|
lead acetate results in increased expression of HDAC9 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094
|
|
| G
|
Hdc
|
histidine decarboxylase
|
increases expression decreases expression
|
ISO EXP
|
lead acetate results in increased expression of HDC mRNA lead acetate results in decreased expression of HDC mRNA
|
CTD |
PMID:11578147 PMID:22609695 |
|
NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219
|
|
| G
|
Hdhd2
|
haloacid dehalogenase-like hydrolase domain containing 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of HDHD2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr18:77,031,775...77,059,867
Ensembl chr18:77,031,788...77,063,003
|
|
| G
|
Hecw1
|
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HECW1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr13:14,401,023...14,697,874
Ensembl chr13:14,401,023...14,697,813
|
|
| G
|
Hepacam2
|
HEPACAM family member 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of HEPACAM2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:3,457,202...3,498,319
Ensembl chr 6:3,457,096...3,498,298
|
|
| G
|
Heph
|
hephaestin
|
increases expression
|
EXP
|
lead acetate results in increased expression of HEPH mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr X:95,499,042...95,618,091
Ensembl chr X:95,498,965...95,618,091
|
|
| G
|
Herpud1
|
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
|
affects expression
|
EXP
|
lead acetate affects the expression of HERPUD1 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 8:95,113,057...95,121,999
Ensembl chr 8:95,113,066...95,122,005
|
|
| G
|
Hes6
|
hairy and enhancer of split 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HES6 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 1:91,339,204...91,342,901
Ensembl chr 1:91,339,205...91,341,760
|
|
| G
|
Hexb
|
hexosaminidase B
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HEXB mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865
|
|
| G
|
Hey2
|
hairy/enhancer-of-split related with YRPW motif 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of HEY2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr10:30,708,355...30,718,779
Ensembl chr10:30,708,355...30,718,797
|
|
| G
|
Heyl
|
hairy/enhancer-of-split related with YRPW motif-like
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HEYL mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 4:123,127,349...123,143,663
Ensembl chr 4:123,127,349...123,143,668
|
|
| G
|
Hfe
|
homeostatic iron regulator
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HFE mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837
|
|
| G
|
Hgsnat
|
heparan-alpha-glucosaminide N-acetyltransferase
|
increases expression
|
EXP
|
lead acetate results in increased expression of HGSNAT mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 8:26,432,495...26,466,704
Ensembl chr 8:26,434,481...26,466,781
|
|
| G
|
Hid1
|
HID1 domain containing
|
affects expression
|
ISO
|
lead acetate affects the expression of HID1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:115,238,531...115,261,087
Ensembl chr11:115,238,533...115,258,582
|
|
| G
|
Hif3a
|
hypoxia inducible factor 3, alpha subunit
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of HIF3A mRNA lead acetate results in increased expression of HIF3A mRNA
|
CTD |
PMID:21829687 PMID:22641619 |
|
NCBI chr 7:16,764,918...16,796,352
Ensembl chr 7:16,765,432...16,796,352
|
|
| G
|
Hilpda
|
hypoxia inducible lipid droplet associated
|
increases expression
|
EXP
|
lead acetate results in increased expression of HILPDA mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:29,272,487...29,275,448
Ensembl chr 6:29,272,487...29,275,445
|
|
| G
|
Hkdc1
|
hexokinase domain containing 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of HKDC1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:62,218,916...62,259,490
Ensembl chr10:62,218,916...62,258,270
|
|
| G
|
Hlcs
|
holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
|
increases expression
|
ISO
|
lead acetate results in increased expression of HLCS mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr16:93,930,054...94,116,098
Ensembl chr16:93,929,741...94,114,430
|
|
| G
|
Hmbs
|
hydroxymethylbilane synthase
|
increases activity
|
ISO
|
lead acetate results in increased activity of HMBS protein
|
CTD |
PMID:10416826 |
|
NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525
|
|
| G
|
Hmgb1
|
high mobility group box 1
|
multiple interactions increases expression
|
ISO
|
copper protoporphyrin IX inhibits the reaction [lead acetate results in increased expression of HMGB1 mRNA]; zinc protoporphyrin promotes the reaction [lead acetate results in increased expression of HMGB1 mRNA] lead acetate results in increased expression of HMGB1 mRNA; lead acetate results in increased expression of HMGB1 protein
|
CTD |
PMID:29447957 |
|
NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
|
|
| G
|
Hmgcr
|
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of HMGCR mRNA; lead acetate results in decreased expression of HMGCR protein SRT1720 inhibits the reaction [lead acetate results in increased expression of HMGCR protein]
|
CTD |
PMID:29908845 PMID:34842334 |
|
NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
|
|
| G
|
Hmgcs1
|
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
|
decreases expression multiple interactions
|
ISO EXP
|
lead acetate results in decreased expression of HMGCS1 mRNA [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of HMGCS1 mRNA; [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of HMGCS1 protein
|
CTD |
PMID:38157908 PMID:38568856 |
|
NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796
|
|
| G
|
Hmgcs2
|
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HMGCS2 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054
|
|
| G
|
Hmmr
|
hyaluronan mediated motility receptor (RHAMM)
|
increases expression
|
EXP
|
lead acetate results in increased expression of HMMR mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:40,592,215...40,624,290
Ensembl chr11:40,592,222...40,624,249
|
|
| G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions increases expression decreases response to substance decreases expression
|
ISO EXP
|
2-tert-butylhydroquinone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 protein]; 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in decreased expression of HMOX1 mRNA]; [lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 protein; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; copper protoporphyrin IX promotes the reaction [lead acetate results in increased expression of HMOX1 mRNA]; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 protein]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 protein]; lead acetate results in increased expression of and results in increased activity of HMOX1 protein; NFE2L2 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 protein]; sinapinic acid inhibits the reaction [lead acetate results in decreased expression of HMOX1 mRNA]; sodium bisulfide inhibits the reaction [lead acetate results in decreased expression of HMOX1 protein]; sodium boranocarbonate inhibits the reaction [lead acetate results in decreased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA] lead acetate results in increased expression of HMOX1 mRNA; lead acetate results in increased expression of HMOX1 protein HMOX1 protein results in decreased susceptibility to lead acetate 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; [[lead acetate results in increased abundance of Lead] which co-treated with Rutin] results in increased expression of HMOX1 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; Ascorbic Acid promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]; HMOX1 protein affects the reaction [lead acetate affects the expression of BCL2L1 protein]; HMOX1 protein affects the reaction [lead acetate affects the expression of CASP3 protein]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]; Rutin promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; U 0126 inhibits the reaction [lead acetate results in increased expression of HMOX1 protein] lead acetate results in decreased expression of HMOX1 mRNA; lead acetate results in decreased expression of HMOX1 protein [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of HMOX1 mRNA; [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of HMOX1 protein; [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of HMOX1 mRNA; [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of HMOX1 protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of HMOX1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of HMOX1 protein; [Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of HMOX1 mRNA]; [Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of HMOX1 protein]
|
CTD |
PMID:12774885 PMID:25270620 PMID:26498409 PMID:26542248 PMID:27562236 PMID:29447957 PMID:30476502 PMID:30623991 PMID:30980911 PMID:31610155 PMID:32116774 PMID:32208856 PMID:33862172 PMID:36642386 PMID:37471654 PMID:37939567 PMID:38157908 PMID:38180308 PMID:38530053 PMID:38568856 PMID:39032614 PMID:39276841 More...
|
|
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
|
|
| G
|
Hmx1
|
H6 homeobox 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of HMX1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:35,546,124...35,557,629
Ensembl chr 5:35,546,452...35,557,074
|
|
| G
|
Hnf1b
|
HNF1 homeobox B
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HNF1B mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:83,741,035...83,796,743
Ensembl chr11:83,740,889...83,796,645
|
|
| G
|
Hnf4g
|
hepatocyte nuclear factor 4, gamma
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HNF4G mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:3,573,090...3,724,863
Ensembl chr 3:3,573,084...3,724,860
|
|
| G
|
Hnrnpa0
|
heterogeneous nuclear ribonucleoprotein A0
|
increases expression
|
ISO
|
lead acetate results in increased expression of HNRNPA0 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:58,273,693...58,276,370
Ensembl chr13:58,273,693...58,276,370
|
|
| G
|
Hnrnpa2b1
|
heterogeneous nuclear ribonucleoprotein A2/B1
|
increases expression
|
EXP
|
lead acetate results in increased expression of HNRNPA2B1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:51,437,414...51,448,054
Ensembl chr 6:51,437,912...51,446,874
|
|
| G
|
Hnrnpdl
|
heterogeneous nuclear ribonucleoprotein D-like
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of HNRNPDL mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:100,181,436...100,187,769
Ensembl chr 5:100,181,436...100,187,523
|
|
| G
|
Hnrnph2
|
heterogeneous nuclear ribonucleoprotein H2
|
increases expression
|
EXP
|
lead acetate results in increased expression of HNRNPH2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr X:133,501,928...133,507,809
Ensembl chr X:133,501,928...133,507,809
|
|
| G
|
Homer1
|
homer scaffolding protein 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of HOMER1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of HOMER1 protein
|
CTD |
PMID:30738087 |
|
NCBI chr13:93,440,265...93,549,471
Ensembl chr13:93,436,143...93,541,637
|
|
| G
|
Hopx
|
HOP homeobox
|
increases expression
|
EXP
|
lead acetate results in increased expression of HOPX mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:77,234,831...77,262,970
Ensembl chr 5:77,234,835...77,262,968
|
|
| G
|
Hotair
|
HOX transcript antisense RNA (non-protein coding)
|
increases expression
|
EXP
|
lead acetate results in increased expression of HOTAIR mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr15:102,852,497...102,856,381
Ensembl chr15:102,852,494...102,862,817
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|
| G
|
Hoxa3
|
homeobox A3
|
increases expression
|
ISO
|
lead acetate results in increased expression of HOXA3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:52,146,039...52,190,316
Ensembl chr 6:52,146,042...52,190,316
|
|
| G
|
Hoxb9
|
homeobox B9
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HOXB9 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:96,162,156...96,167,421
Ensembl chr11:96,162,283...96,167,421
|
|
| G
|
Hoxc6
|
homeobox C6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HOXC6 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:102,906,658...102,920,314
Ensembl chr15:102,906,689...102,920,313
|
|
| G
|
Hoxc8
|
homeobox C8
|
increases expression
|
ISO
|
lead acetate results in increased expression of HOXC8 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:102,898,971...102,902,707
Ensembl chr15:102,899,039...102,902,543
|
|
| G
|
Hp1bp3
|
heterochromatin protein 1, binding protein 3
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of HP1BP3 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 4:137,943,781...137,971,994
Ensembl chr 4:137,943,607...137,971,994
|
|
| G
|
Hprt1
|
hypoxanthine phosphoribosyltransferase 1
|
decreases activity decreases expression
|
ISO EXP
|
lead acetate results in decreased activity of HPRT1 protein lead acetate results in decreased expression of HPRT1 mRNA
|
CTD |
PMID:19428946 PMID:21829687 |
|
NCBI chr X:52,076,955...52,110,537
Ensembl chr X:52,077,014...52,110,536
|
|
| G
|
Hras
|
Harvey rat sarcoma virus oncogene
|
multiple interactions increases activity
|
ISO
|
lead acetate inhibits the reaction [HSPA5 protein binds to HRAS enhancer] lead acetate results in increased activity of HRAS protein 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased activity of HRAS protein]; Go 6976 inhibits the reaction [lead acetate results in increased activity of HRAS protein]; HRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; HRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; HRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of RAF1 protein]; PRKCA mutant form inhibits the reaction [lead acetate results in increased activity of HRAS protein]; SU 6656 inhibits the reaction [lead acetate results in increased activity of HRAS protein]
|
CTD |
PMID:15111246 PMID:19133285 |
|
NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918
|
|
| G
|
Hrh4
|
histamine receptor H4
|
decreases methylation increases expression
|
ISO
|
lead acetate results in decreased methylation of HRH4 gene lead acetate results in increased expression of HRH4 mRNA
|
CTD |
PMID:29571894 |
|
NCBI chr18:13,140,039...13,156,758
Ensembl chr18:13,140,047...13,155,939
|
|
| G
|
Hs3st3a1
|
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
|
increases expression
|
ISO
|
lead acetate results in increased expression of HS3ST3A1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:64,326,158...64,413,667
Ensembl chr11:64,326,158...64,413,667
|
|
| G
|
Hsd11b1
|
hydroxysteroid 11-beta dehydrogenase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of HSD11B1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383
|
|
| G
|
Hsd17b1
|
hydroxysteroid (17-beta) dehydrogenase 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HSD17B1 protein
|
CTD |
PMID:22806249 |
|
NCBI chr11:100,968,792...100,972,014
Ensembl chr11:100,969,237...100,971,353
|
|
| G
|
Hsd17b10
|
hydroxysteroid (17-beta) dehydrogenase 10
|
decreases expression multiple interactions
|
EXP
|
lead acetate results in decreased expression of HSD17B10 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of HSD17B10 mRNA; Glycine inhibits the reaction [lead acetate results in decreased expression of HSD17B10 mRNA]; Taurine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of HSD17B10 mRNA]
|
CTD |
PMID:36088639 PMID:36484981 |
|
NCBI chr X:150,784,892...150,787,438
Ensembl chr X:150,784,841...150,787,438
|
|
| G
|
Hsd17b2
|
hydroxysteroid (17-beta) dehydrogenase 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of HSD17B2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:118,427,752...118,485,767
Ensembl chr 8:118,428,643...118,485,766
|
|
| G
|
Hsd3b1
|
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
|
multiple interactions decreases expression
|
EXP
|
Glycine inhibits the reaction [lead acetate results in decreased expression of HSD3B1 mRNA]
|
CTD |
PMID:36088639 |
|
NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110
|
|
| G
|
Hsd3b3
|
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HSD3B3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:98,648,792...98,672,465
Ensembl chr 3:98,648,839...98,670,443
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| G
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Hsf1
|
heat shock factor 1
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of HSF1 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of HSF1 mRNA
|
CTD |
PMID:21829687 PMID:39276841 |
|
NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
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| G
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Hsp90aa1
|
heat shock protein 90, alpha (cytosolic), class A member 1
|
multiple interactions affects expression
|
ISO EXP
|
[sodium arsenite co-treated with lead acetate] results in increased expression of HSP90AA1 protein lead acetate affects the expression of HSP90AA1 mRNA
|
CTD |
PMID:21829687 PMID:38072110 |
|
NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162
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|
| G
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Hsp90b1
|
heat shock protein 90, beta (Grp94), member 1
|
affects expression
|
EXP
|
lead acetate affects the expression of HSP90B1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373
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| G
|
Hspa1a
|
heat shock protein 1A
|
decreases expression multiple interactions increases expression
|
EXP ISO
|
lead acetate results in decreased expression of HSPA1A mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of HSPA1A mRNA; [sodium arsenite co-treated with lead acetate] results in increased expression of HSPA1A protein lead acetate results in increased expression of HSPA1A mRNA
|
CTD |
PMID:29746905 PMID:38072110 PMID:38568856 PMID:39547369 |
|
NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
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|
| G
|
Hspa1b
|
heat shock protein 1B
|
affects expression
|
EXP
|
lead acetate affects the expression of HSPA1B mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
|
|
| G
|
Hspa2
|
heat shock protein 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of HSPA2 protein
|
CTD |
PMID:38072110 |
|
NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712
|
|
| G
|
Hspa4l
|
heat shock protein 4 like
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of HSPA4L protein
|
CTD |
PMID:38072110 |
|
NCBI chr 3:40,698,664...40,750,538
Ensembl chr 3:40,699,814...40,750,538
|
|
| G
|
Hspa5
|
heat shock protein 5
|
multiple interactions affects localization increases expression affects binding affects expression
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of HSPA5 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of HSPA5 mRNA; ATP7A protein modified form inhibits the reaction [lead acetate binds to HSPA5 protein]; Cycloheximide inhibits the reaction [lead acetate results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [lead acetate results in increased expression of HSPA5 mRNA]; lead acetate inhibits the reaction [HSPA5 protein binds to FOS enhancer]; lead acetate inhibits the reaction [HSPA5 protein binds to HRAS enhancer]; lead acetate results in increased expression of and results in increased activity of HSPA5 protein; Nickel inhibits the reaction [lead acetate binds to HSPA5 protein]; Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of HSPA5 protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of HSPA5 mRNA]; Zinc inhibits the reaction [lead acetate binds to HSPA5 protein] lead acetate affects the localization of HSPA5 protein lead acetate results in increased expression of HSPA5 mRNA; lead acetate results in increased expression of HSPA5 protein lead acetate affects the expression of HSPA5 mRNA
|
CTD |
PMID:10702365 PMID:15111246 PMID:17915553 PMID:21815057 PMID:22811615 PMID:25088297 PMID:30445054 PMID:36642386 PMID:38530053 PMID:39276841 More...
|
|
NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
|
|
| G
|
Hspa8
|
heat shock protein 8
|
affects expression decreases expression
|
EXP
|
lead acetate affects the expression of HSPA8 protein lead acetate results in decreased expression of HSPA8 mRNA
|
CTD |
PMID:20797405 PMID:21829687 |
|
NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383
|
|
| G
|
Hspa9
|
heat shock protein 9
|
increases expression
|
ISO
|
lead acetate results in increased expression of HSPA9 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410
|
|
| G
|
Hspb1
|
heat shock protein 1
|
affects expression multiple interactions
|
ISO EXP
|
lead acetate affects the expression of HSPB1 mRNA [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of HSPB1 mRNA; [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of HSPB1 protein [sodium arsenite co-treated with lead acetate] results in increased expression of HSPB1 protein [lead acetate results in increased abundance of Lead] which results in increased expression of HSPB1 mRNA
|
CTD |
PMID:21864555 PMID:38072110 PMID:38157908 PMID:39276841 |
|
NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417
|
|
| G
|
Hspb8
|
heat shock protein 8
|
increases expression
|
ISO
|
lead acetate results in increased expression of HSPB8 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:116,546,550...116,560,923
Ensembl chr 5:116,546,550...116,560,923
|
|
| G
|
Hspd1
|
heat shock protein 1 (chaperonin)
|
affects expression multiple interactions decreases expression increases expression
|
EXP ISO
|
lead acetate affects the expression of HSPD1 protein [lead acetate results in increased abundance of Lead] which results in increased expression of HSPD1 mRNA; [sodium arsenite co-treated with lead acetate] results in increased expression of HSPD1 protein; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HSPD1 mRNA] lead acetate results in decreased expression of HSPD1 protein lead acetate results in increased expression of HSPD1 mRNA
|
CTD |
PMID:20797405 PMID:21829687 PMID:29660402 PMID:38072110 PMID:39547369 |
|
NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402
|
|
| G
|
Hspe1
|
heat shock protein 1 (chaperonin 10)
|
increases expression
|
ISO
|
lead acetate results in increased expression of HSPE1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 1:55,127,307...55,130,476
Ensembl chr 1:55,127,291...55,130,466
|
|
| G
|
Hsph1
|
heat shock 105kDa/110kDa protein 1
|
affects expression multiple interactions decreases expression
|
EXP ISO
|
lead acetate affects the expression of HSPH1 mRNA [sodium arsenite co-treated with lead acetate] results in increased expression of HSPH1 protein lead acetate results in decreased expression of HSPH1 mRNA
|
CTD |
PMID:21829687 PMID:25270620 PMID:38072110 |
|
NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841
|
|
| G
|
Htatip2
|
HIV-1 Tat interactive protein 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of HTATIP2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:49,408,761...49,423,748
Ensembl chr 7:49,408,863...49,423,723
|
|
| G
|
Htr1b
|
5-hydroxytryptamine (serotonin) receptor 1B
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of HTR1B mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 9:81,510,344...81,515,885
Ensembl chr 9:81,510,344...81,515,881
|
|
| G
|
Htr1d
|
5-hydroxytryptamine (serotonin) receptor 1D
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HTR1D mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 4:136,150,835...136,171,716
Ensembl chr 4:136,150,835...136,171,709
|
|
| G
|
Htr2c
|
5-hydroxytryptamine (serotonin) receptor 2C
|
affects expression decreases expression
|
ISO
|
lead acetate affects the expression of HTR2C mRNA lead acetate results in decreased expression of HTR2C mRNA
|
CTD |
PMID:21864555 PMID:22641619 |
|
NCBI chr X:145,745,509...145,980,273
Ensembl chr X:145,745,509...145,980,273
|
|
| G
|
Htr3a
|
5-hydroxytryptamine (serotonin) receptor 3A
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of HTR3A mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:48,810,513...48,822,451
Ensembl chr 9:48,810,513...48,822,399
|
|
| G
|
Htr5a
|
5-hydroxytryptamine (serotonin) receptor 5A
|
increases expression
|
EXP
|
lead acetate results in increased expression of HTR5A mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:28,046,836...28,059,403
Ensembl chr 5:28,047,147...28,060,086
|
|
| G
|
Htra4
|
HtrA serine peptidase 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of HTRA4 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 8:25,514,944...25,529,160
Ensembl chr 8:25,514,945...25,528,978
|
|
| G
|
Htt
|
huntingtin
|
increases expression
|
EXP
|
lead acetate results in increased expression of HTT mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 5:34,919,084...35,069,878
Ensembl chr 5:34,919,084...35,069,878
|
|
| G
|
Huwe1
|
HECT, UBA and WWE domain containing 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of HUWE1 exon
|
CTD |
PMID:33445541 |
|
NCBI chr X:150,583,779...150,718,413
Ensembl chr X:150,583,803...150,718,413
|
|
| G
|
Hymai
|
hydatidiform mole associated and imprinted transcript
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of HYMAI mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:12,966,589...12,971,644
|
|
| G
|
Hyou1
|
hypoxia up-regulated 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of HYOU1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:44,290,840...44,303,662
Ensembl chr 9:44,290,787...44,303,666
|
|
| G
|
Iars1
|
isoleucyl-tRNA synthetase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of IARS1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr13:49,835,606...49,887,743
Ensembl chr13:49,835,576...49,887,743
|
|
| G
|
Ibsp
|
integrin binding sialoprotein
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IBSP mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:104,447,153...104,459,338
Ensembl chr 5:104,447,037...104,459,335
|
|
| G
|
Icam1
|
intercellular adhesion molecule 1
|
multiple interactions decreases expression
|
EXP
|
[Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of ICAM1 protein lead acetate results in decreased expression of ICAM1 mRNA
|
CTD |
PMID:17512567 PMID:21829687 |
|
NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
|
|
| G
|
Id1
|
inhibitor of DNA binding 1, HLH protein
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID1 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330
|
|
| G
|
Id2
|
inhibitor of DNA binding 2
|
multiple interactions
|
ISO EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of ID2 protein; baricitinib inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of ID2 protein]
|
CTD |
PMID:12634122 PMID:32428222 |
|
NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139
|
|
| G
|
Id3
|
inhibitor of DNA binding 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ID3 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066
|
|
| G
|
Ide
|
insulin degrading enzyme
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IDE protein
|
CTD |
PMID:28427492 |
|
NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010
|
|
| G
|
Idh1
|
isocitrate dehydrogenase 1 (NADP+), soluble
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IDH1 mRNA
|
CTD |
PMID:29746905 |
|
NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659
|
|
| G
|
Ido1
|
indoleamine 2,3-dioxygenase 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of IDO1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025
|
|
| G
|
Ier3
|
immediate early response 3
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of IER3 mRNA lead acetate results in increased expression of IER3 mRNA
|
CTD |
PMID:20542052 PMID:38568856 |
|
NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815
|
|
| G
|
Ifi202b
|
interferon activated gene 202B
|
affects expression
|
EXP
|
lead acetate affects the expression of IFI202B mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:173,790,135...173,810,410
Ensembl chr 1:173,790,134...173,810,310
|
|
| G
|
Ifi204
|
interferon activated gene 204
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of IFI16 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:173,574,859...173,594,606
Ensembl chr 1:173,574,859...173,594,509
|
|
| G
|
Ifi35
|
interferon-induced protein 35
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IFI35 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:101,339,238...101,349,527
Ensembl chr11:101,339,233...101,349,524
|
|
| G
|
Ifi44
|
interferon-induced protein 44
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of IFI44 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:151,436,559...151,455,580
Ensembl chr 3:151,436,559...151,455,597
|
|
| G
|
Ifi44l
|
interferon-induced protein 44 like
|
affects expression decreases expression
|
EXP
|
lead acetate affects the expression of IFI44L mRNA lead acetate results in decreased expression of IFI44L mRNA
|
CTD |
PMID:21829687 PMID:22609695 |
|
NCBI chr 3:151,464,374...151,468,528
Ensembl chr 3:151,464,374...151,468,529
|
|
| G
|
Ifit1
|
interferon-induced protein with tetratricopeptide repeats 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IFIT1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr19:34,618,289...34,627,409
Ensembl chr19:34,618,271...34,627,409
|
|
| G
|
Ifitm2
|
interferon induced transmembrane protein 2
|
increases expression decreases expression
|
ISO
|
lead acetate results in increased expression of IFITM2 mRNA lead acetate results in decreased expression of IFITM2 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr 7:140,534,750...140,539,602
Ensembl chr 7:140,534,750...140,535,900
|
|
| G
|
Ifitm3
|
interferon induced transmembrane protein 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of IFITM3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:140,589,503...140,590,657
Ensembl chr 7:140,589,499...140,590,683
|
|
| G
|
Ifitm6
|
interferon induced transmembrane protein 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of IFITM6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:140,595,725...140,596,805
Ensembl chr 7:140,595,612...140,597,837
|
|
| G
|
Ifnar2
|
interferon (alpha and beta) receptor 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IFNAR2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:91,166,517...91,202,477
Ensembl chr16:91,169,671...91,202,477
|
|
| G
|
Ifng
|
interferon gamma
|
decreases expression multiple interactions
|
ISO EXP
|
lead acetate results in decreased expression of IFNG protein [[lead acetate results in increased abundance of Lead] co-treated with [Lipopolysaccharides co-treated with IFNG protein]] results in increased expression of H2 protein; [lead acetate results in increased abundance of Lead] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]; [lead acetate results in increased abundance of Lead] promotes the reaction [[IL4 protein co-treated with IFNG protein] results in increased expression of MRC1 protein] [lead acetate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
|
CTD |
PMID:15843504 PMID:29594315 PMID:34352350 |
|
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
|
|
| G
|
Ifngr1
|
interferon gamma receptor 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of IFNGR1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977
|
|
| G
|
Ifrd1
|
interferon-related developmental regulator 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of IFRD1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr12:40,253,128...40,273,184
Ensembl chr12:40,251,566...40,298,503
|
|
| G
|
Ift172
|
intraflagellar transport 172
|
increases expression
|
EXP
|
lead acetate results in increased expression of IFT172 mRNA
|
CTD |
PMID:29746905 |
|
NCBI chr 5:31,410,623...31,448,458
Ensembl chr 5:31,410,621...31,448,460
|
|
| G
|
Igf1
|
insulin-like growth factor 1
|
decreases expression increases methylation multiple interactions
|
EXP ISO
|
lead acetate results in decreased expression of IGF1 protein lead acetate results in increased methylation of IGF1 gene [lead acetate results in increased abundance of Lead] which results in decreased expression of IGF1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of IGF1 protein
|
CTD |
PMID:24200854 PMID:29571894 PMID:36652739 |
|
NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
|
|
| G
|
Igf1r
|
insulin-like growth factor I receptor
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of IGF1R mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of IGF1R protein
|
CTD |
PMID:36652739 |
|
NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
|
|
| G
|
Igf2
|
insulin-like growth factor 2
|
affects expression decreases methylation decreases expression
|
ISO EXP
|
lead acetate affects the expression of IGF2 mRNA lead acetate results in decreased methylation of IGF2 gene lead acetate results in decreased expression of IGF2 mRNA lead acetate results in decreased expression of IGF2 protein
|
CTD |
PMID:21864555 PMID:24200854 PMID:25596546 |
|
NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553
|
|
| G
|
Igf2bp3
|
insulin-like growth factor 2 mRNA binding protein 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of IGF2BP3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:49,062,152...49,200,225
Ensembl chr 6:49,062,157...49,191,891
|
|
| G
|
Igfbp1
|
insulin-like growth factor binding protein 1
|
increases expression decreases expression
|
EXP
|
lead acetate results in increased expression of IGFBP1 mRNA lead acetate results in decreased expression of IGFBP1 mRNA
|
CTD |
PMID:21335049 PMID:25270620 |
|
NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546
|
|
| G
|
Igfbp3
|
insulin-like growth factor binding protein 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of IGFBP3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923
|
|
| G
|
Igfbp5
|
insulin-like growth factor binding protein 5
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of IGFBP5 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043
|
|
| G
|
Igfbp6
|
insulin-like growth factor binding protein 6
|
increases expression
|
ISO
|
lead acetate results in increased expression of IGFBP6 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:102,052,621...102,057,947
Ensembl chr15:102,052,797...102,057,946
|
|
| G
|
Igfbp7
|
insulin-like growth factor binding protein 7
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of IGFBP7 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 5:77,497,092...77,555,892
Ensembl chr 5:77,497,087...77,555,888
|
|
| G
|
Igfbpl1
|
insulin-like growth factor binding protein-like 1
|
affects expression
|
ISO
|
lead acetate affects the expression of IGFBPL1 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 4:45,809,507...45,826,827
Ensembl chr 4:45,809,468...45,826,923
|
|
| G
|
Igkv1-135
|
immunoglobulin kappa variable 1-135
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IGKV1-135 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:67,586,729...67,587,492
Ensembl chr 6:67,586,697...67,587,492
|
|
| G
|
Igsf6
|
immunoglobulin superfamily, member 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IGSF6 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:120,663,290...120,673,753
Ensembl chr 7:120,663,290...120,673,795
|
|
| G
|
Ihh
|
Indian hedgehog
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of IHH protein
|
CTD |
PMID:23604592 |
|
NCBI chr 1:74,984,474...74,990,831
Ensembl chr 1:74,984,474...74,990,831
|
|
| G
|
Iigp1
|
interferon inducible GTPase 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of IIGP1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr18:60,506,688...60,525,706
Ensembl chr18:60,509,099...60,525,706
|
|
| G
|
Iigp1b
|
interferon inducible GTPase 1B
|
increases expression
|
EXP
|
lead acetate results in increased expression of IIGP1B mRNA
|
CTD |
PMID:21829687 |
|
|
|
| G
|
Ikbkg
|
inhibitor of kappaB kinase gamma
|
increases expression
|
ISO
|
lead acetate results in increased expression of IKBKG mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr X:73,436,883...73,498,013
Ensembl chr X:73,436,896...73,497,460
|
|
| G
|
Il10
|
interleukin 10
|
decreases expression multiple interactions
|
ISO EXP
|
lead acetate results in decreased expression of IL10 mRNA; lead acetate results in decreased expression of IL10 protein [[lead acetate results in increased abundance of Lead] which co-treated with Rutin] results in increased expression of IL10 mRNA; [[lead acetate results in increased abundance of Lead] which co-treated with Rutin] results in increased expression of IL10 protein; NFE2L2 protein affects the reaction [[[lead acetate results in increased abundance of Lead] which co-treated with Rutin] results in increased expression of IL10 mRNA]; NFE2L2 protein affects the reaction [[[lead acetate results in increased abundance of Lead] which co-treated with Rutin] results in increased expression of IL10 protein] Cholecalciferol inhibits the reaction [lead acetate results in decreased expression of IL10 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of IL10 protein] [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of IL10 protein
|
CTD |
PMID:17512567 PMID:22609695 PMID:32116774 PMID:34051273 PMID:39032614 |
|
NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
|
|
| G
|
Il10ra
|
interleukin 10 receptor, alpha
|
increases expression
|
EXP
|
lead acetate results in increased expression of IL10RA mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447
|
|
| G
|
Il11
|
interleukin 11
|
increases expression
|
ISO
|
lead acetate results in increased expression of IL11 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858
|
|
| G
|
Il12a
|
interleukin 12a
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IL12A mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
|
|
| G
|
Il13
|
interleukin 13
|
multiple interactions
|
EXP
|
[[lead acetate results in increased abundance of Lead] co-treated with [IL4 protein co-treated with IL13 protein]] results in increased expression of TGFB1 protein
|
CTD |
PMID:34352350 |
|
NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
|
|
| G
|
Il18
|
interleukin 18
|
affects expression increases expression
|
EXP ISO
|
lead acetate affects the expression of IL18 protein lead acetate results in increased expression of IL18 mRNA
|
CTD |
PMID:21322097 PMID:33862172 PMID:37939567 |
|
NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
|
|
| G
|
Il18bp
|
interleukin 18 binding protein
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IL18BP mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:101,664,281...101,669,699
Ensembl chr 7:101,664,092...101,667,897
|
|
| G
|
Il18rap
|
interleukin 18 receptor accessory protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of IL18RAP mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:40,554,548...40,590,867
Ensembl chr 1:40,554,522...40,590,865
|
|
| G
|
Il1a
|
interleukin 1 alpha
|
increases expression
|
ISO
|
lead acetate results in increased expression of IL1A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
|
|
| G
|
Il1b
|
interleukin 1 beta
|
decreases expression multiple interactions increases expression increases secretion
|
ISO EXP
|
lead acetate results in decreased expression of IL1B protein [lead acetate results in increased abundance of Lead] which results in increased expression of IL1B mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of IL1B protein; NFE2L2 protein affects the reaction [Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of IL1B mRNA]]; NFE2L2 protein affects the reaction [Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of IL1B protein]]; Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of IL1B protein] lead acetate results in increased expression of IL1B mRNA lead acetate results in increased expression of IL1B protein lead acetate results in increased secretion of IL1B protein 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL1B protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL1B protein; [lead acetate results in increased abundance of Lead] which results in increased expression of IL1B protein; MitoTEMPO inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL1B protein]; NLRP3 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL1B protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in increased secretion of IL1B protein] lead acetate results in decreased expression of IL1B mRNA lead acetate results in increased expression of IL1B mRNA; lead acetate results in increased expression of IL1B protein 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lead acetate results in increased expression of IL1B protein]; 3-methyladenine inhibits the reaction [lead acetate results in increased expression of IL1B protein]; 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in increased expression of IL1B mRNA]; 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in increased expression of IL1B protein]; Ascorbic Acid inhibits the reaction [lead acetate results in increased expression of IL1B protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of IL1B protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL1B protein]; naringenin inhibits the reaction [lead acetate results in increased expression of IL1B protein]; Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of IL1B protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of IL1B protein]; Quercetin inhibits the reaction [lead acetate results in increased expression of IL1B protein]; SB 203580 inhibits the reaction [lead acetate results in increased expression of IL1B protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of IL1B mRNA]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of IL1B protein]; sodium bisulfide inhibits the reaction [lead acetate results in increased expression of IL1B protein]; sodium boranocarbonate inhibits the reaction [lead acetate results in increased expression of IL1B protein]
|
CTD |
PMID:15843504 PMID:17047031 PMID:22728154 PMID:22952811 PMID:25028260 PMID:25088297 PMID:29457680 PMID:30980911 PMID:32116774 PMID:32208856 PMID:32879255 PMID:33862172 PMID:36308466 PMID:36539177 PMID:36807407 PMID:37471654 PMID:38281554 PMID:38530053 PMID:38568856 PMID:39032614 More...
|
|
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
|
|
| G
|
Il1r1
|
interleukin 1 receptor, type I
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of IL1R1 protein
|
CTD |
PMID:26396915 |
|
NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417
|
|
| G
|
Il1r2
|
interleukin 1 receptor, type II
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of IL1R2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391
|
|
| G
|
Il1rl1
|
interleukin 1 receptor-like 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of IL1RL1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575
|
|
| G
|
Il1rl2
|
interleukin 1 receptor-like 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of IL1RL2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:40,363,697...40,406,722
Ensembl chr 1:40,363,770...40,406,722
|
|
| G
|
Il1rn
|
interleukin 1 receptor antagonist
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of IL1RN mRNA IL1RN protein inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]
|
CTD |
PMID:25270620 PMID:26396915 |
|
NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
|
|
| G
|
Il2
|
interleukin 2
|
multiple interactions
|
ISO
|
[lead acetate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
|
CTD |
PMID:29594315 |
|
NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
|
|
| G
|
Il20
|
interleukin 20
|
increases expression
|
EXP
|
lead acetate results in increased expression of IL20 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:130,834,722...130,839,033
Ensembl chr 1:130,834,722...130,839,188
|
|
| G
|
Il21
|
interleukin 21
|
increases expression
|
EXP
|
lead acetate results in increased expression of IL21 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785
|
|
| G
|
Il24
|
interleukin 24
|
increases expression
|
ISO
|
lead acetate results in increased expression of IL24 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
|
|
| G
|
Il31
|
interleukin 31
|
increases expression
|
EXP
|
lead acetate results in increased expression of IL31 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:123,618,215...123,620,686
Ensembl chr 5:123,618,220...123,627,552
|
|
| G
|
Il4
|
interleukin 4
|
increases expression multiple interactions decreases expression
|
EXP ISO
|
lead acetate results in increased expression of IL4 mRNA Cholecalciferol inhibits the reaction [lead acetate results in decreased expression of IL4 protein]; lead acetate promotes the reaction [Zinc Oxide results in decreased expression of IL4 protein]; Zinc Oxide promotes the reaction [lead acetate results in decreased expression of IL4 protein] [[lead acetate results in increased abundance of Lead] co-treated with [IL4 protein co-treated with IL13 protein]] results in increased expression of TGFB1 protein; [lead acetate results in increased abundance of Lead] promotes the reaction [[IL4 protein co-treated with IFNG protein] results in increased expression of MRC1 protein]
|
CTD |
PMID:20542052 PMID:34051273 PMID:34352350 PMID:34553816 |
|
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
|
|
| G
|
Il4ra
|
interleukin 4 receptor, alpha
|
increases expression
|
EXP
|
lead acetate results in increased expression of IL4RA mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646
|
|
| G
|
Il5
|
interleukin 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of IL5 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
|
|
| G
|
Il6
|
interleukin 6
|
affects expression increases expression multiple interactions decreases secretion increases secretion decreases expression
|
EXP ISO
|
lead acetate affects the expression of IL6 protein lead acetate results in increased expression of IL6 protein 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lead acetate results in increased expression of IL6 protein]; Ascorbic Acid inhibits the reaction [lead acetate results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of IL6 protein]; Quercetin inhibits the reaction [lead acetate results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [lead acetate results in increased expression of IL6 protein] lead acetate results in decreased secretion of IL6 protein [lead acetate results in increased abundance of Lead] which results in increased expression of IL6 mRNA; lead acetate promotes the reaction [Hemagglutinins results in increased secretion of IL6 protein] lead acetate results in increased secretion of IL6 protein lead acetate results in decreased expression of IL6 mRNA lead acetate results in increased expression of IL6 mRNA; lead acetate results in increased expression of IL6 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased secretion of IL6 protein]; 3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in increased expression of IL6 protein]; [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of IL6 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL6 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of IL6 protein; [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of IL6 protein; Celecoxib inhibits the reaction [lead acetate results in increased secretion of IL6 protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL6 protein]; MitoTEMPO inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL6 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL6 protein]; NLRP3 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL6 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in increased secretion of IL6 protein]; U 0126 inhibits the reaction [lead acetate results in increased secretion of IL6 protein]
|
CTD |
PMID:17047031 PMID:17512567 PMID:21322097 PMID:21815057 PMID:22728154 PMID:22839698 PMID:23598043 PMID:24530660 PMID:25028260 PMID:36308466 PMID:36539177 PMID:37385299 PMID:38180308 PMID:38281554 PMID:38568856 PMID:39032614 More...
|
|
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
|
|
| G
|
Il6ra
|
interleukin 6 receptor, alpha
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IL6RA mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503
|
|
| G
|
Il7
|
interleukin 7
|
increases expression
|
EXP
|
lead acetate results in increased expression of IL7 mRNA
|
CTD |
PMID:20542052 PMID:22609695 |
|
NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820
|
|
| G
|
Il7r
|
interleukin 7 receptor
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of IL7R mRNA lead acetate results in decreased expression of IL7R mRNA
|
CTD |
PMID:20542052 PMID:22609695 PMID:38568856 |
|
NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262
|
|
| G
|
Ilk
|
integrin linked kinase
|
affects expression
|
ISO
|
lead acetate affects the expression of ILK protein
|
CTD |
PMID:36539177 |
|
NCBI chr 7:105,385,797...105,392,132
Ensembl chr 7:105,385,799...105,392,132
|
|
| G
|
Ing1
|
inhibitor of growth family, member 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ING1 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 8:11,605,762...11,613,251
Ensembl chr 8:11,605,571...11,613,251
|
|
| G
|
Ing4
|
inhibitor of growth family, member 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ING4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:125,016,811...125,026,228
Ensembl chr 6:125,016,723...125,026,228
|
|
| G
|
Inhba
|
inhibin beta-A
|
increases expression
|
EXP
|
lead acetate results in increased expression of INHBA mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206
|
|
| G
|
Inhbb
|
inhibin beta-B
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of INHBB mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 1:119,343,193...119,349,978
Ensembl chr 1:119,343,195...119,349,978
|
|
| G
|
Inhbe
|
inhibin beta-E
|
increases expression
|
EXP
|
lead acetate results in increased expression of INHBE mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280
|
|
| G
|
Ino80e
|
INO80 complex subunit E
|
increases expression
|
ISO
|
lead acetate results in increased expression of INO80E mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr 7:126,450,756...126,461,544
Ensembl chr 7:126,450,132...126,461,549
|
|
| G
|
Inpp1
|
inositol polyphosphate-1-phosphatase
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of INPP1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:52,824,584...52,856,847
Ensembl chr 1:52,824,586...52,856,847
|
|
| G
|
Ins1
|
insulin I
|
increases expression
|
EXP
|
lead acetate results in increased expression of INS1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
|
|
| G
|
Insr
|
insulin receptor
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of INSR mRNA
|
CTD |
PMID:30980912 |
|
NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
|
|
| G
|
Insyn2b
|
inhibitory synaptic factor family member 2B
|
increases expression
|
ISO
|
lead acetate results in increased expression of INSYN2B mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:34,264,822...34,372,642
Ensembl chr11:34,264,758...34,372,640
|
|
| G
|
Ipo5
|
importin 5
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of IPO5 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:121,134,271...121,185,451
Ensembl chr14:121,148,636...121,185,411
|
|
| G
|
Ipo7
|
importin 7
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of IPO7 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:109,617,522...109,655,816
Ensembl chr 7:109,617,481...109,655,816
|
|
| G
|
Irag2
|
inositol 1,4,5-triphosphate receptor associated 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IRAG2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:145,061,357...145,120,655
Ensembl chr 6:145,061,379...145,120,660
|
|
| G
|
Irak1
|
interleukin-1 receptor-associated kinase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of IRAK1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr X:73,057,520...73,067,527
Ensembl chr X:73,057,520...73,067,524
|
|
| G
|
Irf2bp1
|
interferon regulatory factor 2 binding protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of IRF2BP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:18,737,983...18,740,688
Ensembl chr 7:18,737,969...18,740,702
|
|
| G
|
Irf2bp2
|
interferon regulatory factor 2 binding protein 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of IRF2BP2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 8:127,315,035...127,320,725
Ensembl chr 8:127,315,035...127,320,725
|
|
| G
|
Irf2bpl
|
interferon regulatory factor 2 binding protein-like
|
increases expression
|
ISO
|
lead acetate results in increased expression of IRF2BPL mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:86,927,477...86,931,588
Ensembl chr12:86,927,475...86,931,572
|
|
| G
|
Irf4
|
interferon regulatory factor 4
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IRF4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959
|
|
| G
|
Irf6
|
interferon regulatory factor 6
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of IRF6 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:192,835,420...192,854,344
Ensembl chr 1:192,835,419...192,854,331
|
|
| G
|
Irs1
|
insulin receptor substrate 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of IRS1 mRNA
|
CTD |
PMID:30980912 |
|
NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137
|
|
| G
|
Irs2
|
insulin receptor substrate 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of IRS2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458
|
|
| G
|
Itga3
|
integrin alpha 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of ITGA3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:94,935,301...94,967,637
Ensembl chr11:94,935,300...94,967,627
|
|
| G
|
Itga5
|
integrin alpha 5 (fibronectin receptor alpha)
|
increases expression
|
ISO
|
lead acetate results in increased expression of ITGA5 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:103,252,713...103,275,218
Ensembl chr15:103,252,713...103,275,190
|
|
| G
|
Itga6
|
integrin alpha 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ITGA6 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:71,617,236...71,688,761
Ensembl chr 2:71,575,960...71,688,760
|
|
| G
|
Itgae
|
integrin alpha E, epithelial-associated
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of ITGAE protein
|
CTD |
PMID:38072110 |
|
NCBI chr11:72,981,396...73,038,272
Ensembl chr11:72,981,409...73,038,272
|
|
| G
|
Itgal
|
integrin alpha L
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ITGAL mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310
|
|
| G
|
Itgax
|
integrin alpha X
|
increases expression
|
EXP
|
lead acetate results in increased expression of ITGAX mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:127,728,697...127,749,829
Ensembl chr 7:127,728,719...127,749,829
|
|
| G
|
Itgb1
|
integrin beta 1 (fibronectin receptor beta)
|
increases expression
|
EXP
|
lead acetate results in increased expression of ITGB1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681
|
|
| G
|
Itgb3bp
|
integrin beta 3 binding protein (beta3-endonexin)
|
increases expression
|
EXP
|
lead acetate results in increased expression of ITGB3BP mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:99,655,643...99,717,403
Ensembl chr 4:99,653,639...99,787,010
|
|
| G
|
Itgb4
|
integrin beta 4
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of ITGB4 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238
|
|
| G
|
Itgb5
|
integrin beta 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of ITGB5 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:33,650,021...33,769,708
Ensembl chr16:33,650,035...33,769,708
|
|
| G
|
Itgbl1
|
integrin, beta-like 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ITGBL1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr14:123,897,331...124,215,173
Ensembl chr14:123,897,383...124,213,030
|
|
| G
|
Itih4
|
inter alpha-trypsin inhibitor, heavy chain 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of ITIH4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr14:30,608,433...30,623,943
Ensembl chr14:30,608,433...30,624,310
|
|
| G
|
Itih5
|
inter-alpha-trypsin inhibitor, heavy chain 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of ITIH5 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:10,158,354...10,261,340
Ensembl chr 2:10,158,382...10,261,340
|
|
| G
|
Itm2b
|
integral membrane protein 2B
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of ITM2B protein
|
CTD |
PMID:38072110 |
|
NCBI chr14:73,599,666...73,622,729
Ensembl chr14:73,599,666...73,622,729
|
|
| G
|
Itm2c
|
integral membrane protein 2C
|
increases expression
|
ISO
|
lead acetate results in increased expression of ITM2C mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:85,822,231...85,836,419
Ensembl chr 1:85,822,002...85,836,396
|
|
| G
|
Itpkc
|
inositol 1,4,5-trisphosphate 3-kinase C
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ITPKC mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:26,906,595...26,928,042
Ensembl chr 7:26,906,597...26,928,086
|
|
| G
|
Itpr1
|
inositol 1,4,5-trisphosphate receptor 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of ITPR1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070
|
|
| G
|
Ivd
|
isovaleryl coenzyme A dehydrogenase
|
increases expression
|
EXP
|
lead acetate results in increased expression of IVD protein
|
CTD |
PMID:20797405 |
|
NCBI chr 2:118,692,475...118,713,388
Ensembl chr 2:118,692,435...118,713,390
|
|
| G
|
Jak1
|
Janus kinase 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of JAK1 protein
|
CTD |
PMID:32428222 |
|
NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479
|
|
| G
|
Jhy
|
junctional cadherin complex regulator
|
affects expression
|
ISO
|
lead acetate affects the expression of JHY mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:40,806,147...40,877,560
Ensembl chr 9:40,806,145...40,875,414
|
|
| G
|
Jkamp
|
JNK1/MAPK8-associated membrane protein
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of JKAMP mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr12:72,132,348...72,148,301
Ensembl chr12:72,132,363...72,148,235
|
|
| G
|
Jmjd6
|
jumonji domain containing 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of JMJD6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:116,728,258...116,734,593
Ensembl chr11:116,728,258...116,734,275
|
|
| G
|
Jpt2
|
Jupiter microtubule associated homolog 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of JPT2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr17:25,161,444...25,179,597
Ensembl chr17:25,156,393...25,179,663
|
|
| G
|
Jun
|
jun proto-oncogene
|
increases expression
|
ISO
|
lead acetate results in increased expression of JUN mRNA; lead acetate results in increased expression of JUN protein
|
CTD |
PMID:23765435 PMID:38568856 |
|
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
|
|
| G
|
Junb
|
jun B proto-oncogene
|
multiple interactions decreases expression
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of JUNB mRNA lead acetate results in decreased expression of JUNB mRNA
|
CTD |
PMID:12634122 PMID:22641619 |
|
NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347
|
|
| G
|
Jup
|
junction plakoglobin
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of JUP mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:100,259,682...100,288,639
Ensembl chr11:100,259,784...100,288,589
|
|
| G
|
Kalrn
|
kalirin, RhoGEF kinase
|
increases expression decreases expression
|
EXP
|
lead acetate results in increased expression of KALRN mRNA lead acetate results in decreased expression of KALRN mRNA
|
CTD |
PMID:20542052 PMID:22609695 |
|
NCBI chr16:33,789,443...34,393,647
Ensembl chr16:33,789,443...34,393,902
|
|
| G
|
Kank1
|
KN motif and ankyrin repeat domains 1
|
decreases expression multiple interactions
|
EXP
|
lead acetate results in decreased expression of KANK1 mRNA [lead acetate results in increased abundance of Lead] which results in increased methylation of KANK1 exon; [lead acetate results in increased abundance of Lead] which results in increased methylation of KANK1 intron; [lead acetate results in increased abundance of Lead] which results in increased methylation of KANK1 promoter
|
CTD |
PMID:22613225 PMID:33445541 |
|
NCBI chr19:25,214,146...25,411,861
Ensembl chr19:25,214,339...25,411,860
|
|
| G
|
Kap
|
kidney androgen regulated protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of KAP mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:133,826,818...133,830,630
Ensembl chr 6:133,826,814...133,830,725
|
|
| G
|
Kat6a
|
K(lysine) acetyltransferase 6A
|
increases expression
|
EXP
|
lead acetate results in increased expression of KAT6A mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 8:23,349,458...23,433,275
Ensembl chr 8:23,349,551...23,433,275
|
|
| G
|
Katnal1
|
katanin p60 subunit A-like 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of KATNAL1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:148,808,394...148,865,978
Ensembl chr 5:148,808,394...148,931,957
|
|
| G
|
Kcnab1
|
potassium voltage-gated channel, shaker-related subfamily, beta member 1
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KCNAB1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 3:64,856,636...65,285,643
Ensembl chr 3:64,856,617...65,285,644
|
|
| G
|
Kcnb1
|
potassium voltage gated channel, Shab-related subfamily, member 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of KCNB1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:166,937,889...167,032,088
Ensembl chr 2:166,937,889...167,032,075
|
|
| G
|
Kcnip2
|
Kv channel-interacting protein 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of KCNIP2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr19:45,780,785...45,804,948
Ensembl chr19:45,780,278...45,804,500
|
|
| G
|
Kcnj16
|
potassium inwardly-rectifying channel, subfamily J, member 16
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of KCNJ16 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:110,858,859...110,918,794
Ensembl chr11:110,858,859...110,918,794
|
|
| G
|
Kcnj5
|
potassium inwardly-rectifying channel, subfamily J, member 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of KCNJ5 mRNA
|
CTD |
PMID:21829687 PMID:22609695 |
|
NCBI chr 9:32,226,002...32,255,640
Ensembl chr 9:32,226,003...32,255,646
|
|
| G
|
Kcnk2
|
potassium channel, subfamily K, member 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of KCNK2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:188,940,127...189,134,951
Ensembl chr 1:188,940,127...189,134,470
|
|
| G
|
Kcnn4
|
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
|
multiple interactions increases activity
|
EXP
|
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of KCNN4 protein]
|
CTD |
PMID:22033380 |
|
NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115
|
|
| G
|
Kctd1
|
potassium channel tetramerisation domain containing 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of KCTD1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr18:15,101,742...15,284,503
Ensembl chr18:15,101,742...15,284,503
|
|
| G
|
Kctd20
|
potassium channel tetramerisation domain containing 20
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KCTD20 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr17:29,171,420...29,188,523
Ensembl chr17:29,170,924...29,188,523
|
|
| G
|
Kdelr3
|
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of KDELR3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:79,400,609...79,411,940
Ensembl chr15:79,400,612...79,411,940
|
|
| G
|
Kdm3a
|
lysine (K)-specific demethylase 3A
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of KDM3A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:71,565,954...71,609,963
Ensembl chr 6:71,565,956...71,609,974
|
|
| G
|
Kdm3b
|
KDM3B lysine (K)-specific demethylase 3B
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of KDM3B protein
|
CTD |
PMID:38072110 |
|
NCBI chr18:34,910,061...34,972,423
Ensembl chr18:34,910,100...34,971,713
|
|
| G
|
Kdr
|
kinase insert domain protein receptor
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of KDR mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
|
|
| G
|
Keap1
|
kelch-like ECH-associated protein 1
|
multiple interactions decreases expression
|
ISO EXP
|
[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein] [lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 mRNA [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of KEAP1 mRNA; [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of KEAP1 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein; [Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 mRNA]; [Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein] lead acetate results in decreased expression of KEAP1 mRNA
|
CTD |
PMID:31610155 PMID:33862172 PMID:38180308 PMID:39276841 |
|
NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
|
|
| G
|
Khk
|
ketohexokinase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of KHK mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:31,078,780...31,088,592
Ensembl chr 5:31,078,775...31,088,592
|
|
| G
|
Kidins220
|
kinase D-interacting substrate 220
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of KIDINS220 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr12:25,024,909...25,113,151
Ensembl chr12:25,024,924...25,113,151
|
|
| G
|
Kif11
|
kinesin family member 11
|
decreases expression increases expression
|
EXP
|
lead acetate results in decreased expression of KIF11 mRNA lead acetate results in increased expression of KIF11 mRNA
|
CTD |
PMID:20542052 PMID:22609695 |
|
NCBI chr19:37,364,830...37,410,311
Ensembl chr19:37,364,851...37,410,307
|
|
| G
|
Kif13b
|
kinesin family member 13B
|
increases expression
|
EXP
|
lead acetate results in increased expression of KIF13B mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr14:64,889,633...65,047,067
Ensembl chr14:64,884,714...65,047,066
|
|
| G
|
Kif17
|
kinesin family member 17
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of KIF17 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:137,989,562...138,029,284
Ensembl chr 4:137,977,746...138,029,278
|
|
| G
|
Kif19a
|
kinesin family member 19A
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of KIF19A mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:114,656,227...114,681,565
Ensembl chr11:114,656,214...114,681,565
|
|
| G
|
Kif1b
|
kinesin family member 1B
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of KIF1B mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:149,260,776...149,392,762
Ensembl chr 4:149,260,776...149,392,150
|
|
| G
|
Kif1c
|
kinesin family member 1C
|
increases expression
|
ISO
|
lead acetate results in increased expression of KIF1C mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:70,591,170...70,622,796
Ensembl chr11:70,591,374...70,622,790
|
|
| G
|
Kif23
|
kinesin family member 23
|
increases expression
|
EXP
|
lead acetate results in increased expression of KIF23 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:61,824,559...61,854,078
Ensembl chr 9:61,823,187...61,854,056
|
|
| G
|
Kif3b
|
kinesin family member 3B
|
decreases methylation
|
ISO
|
lead acetate results in decreased methylation of KIF3B gene
|
CTD |
PMID:29571894 |
|
NCBI chr 2:153,132,028...153,175,310
Ensembl chr 2:153,133,333...153,175,310
|
|
| G
|
Kif5a
|
kinesin family member 5A
|
increases expression multiple interactions
|
EXP
|
lead acetate results in increased expression of KIF5A mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of KIF5A mRNA; [lead acetate results in increased abundance of Lead] which results in increased methylation of KIF5A intron
|
CTD |
PMID:22609695 PMID:32458983 PMID:33445541 |
|
NCBI chr10:127,061,564...127,102,217
Ensembl chr10:127,061,565...127,099,217
|
|
| G
|
Kirrel3
|
kirre like nephrin family adhesion molecule 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of KIRREL3 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 9:34,396,850...34,952,103
Ensembl chr 9:34,397,190...34,948,012
|
|
| G
|
Kitl
|
kit ligand
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of KITLG mRNA [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KITLG mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278
|
|
| G
|
Kl
|
klotho
|
affects expression decreases expression multiple interactions
|
ISO EXP
|
lead acetate affects the expression of KL mRNA lead acetate results in decreased expression of KL mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of KL protein
|
CTD |
PMID:21864555 PMID:22609695 PMID:39150886 |
|
NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282
|
|
| G
|
Klc2
|
kinesin light chain 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of KLC2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:5,157,774...5,168,326
Ensembl chr19:5,157,774...5,168,588
|
|
| G
|
Klf16
|
Kruppel-like transcription factor 16
|
increases expression
|
ISO
|
lead acetate results in increased expression of KLF16 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:80,402,955...80,413,130
Ensembl chr10:80,402,958...80,413,155
|
|
| G
|
Klf6
|
Kruppel-like transcription factor 6
|
increases methylation increases expression
|
ISO EXP
|
lead acetate results in increased methylation of KLF6 gene lead acetate results in increased expression of KLF6 mRNA
|
CTD |
PMID:25270620 PMID:29571894 |
|
NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393
|
|
| G
|
Klf9
|
Kruppel-like transcription factor 9
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of KLF9 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr19:23,118,590...23,145,493
Ensembl chr19:23,118,590...23,145,498
|
|
| G
|
Klhdc2
|
kelch domain containing 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of KLHDC2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr12:69,343,455...69,357,461
Ensembl chr12:69,343,455...69,357,461
|
|
| G
|
Klhl1
|
kelch-like 1
|
decreases expression increases methylation
|
EXP ISO
|
lead acetate results in decreased expression of KLHL1 mRNA lead acetate results in increased methylation of KLHL1 gene
|
CTD |
PMID:22613225 PMID:29571894 |
|
NCBI chr14:96,342,695...96,756,525
Ensembl chr14:96,340,172...96,756,538
|
|
| G
|
Klk1b24
|
kallikrein 1-related peptidase b24
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of KLK1B24 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:43,837,658...43,841,879
Ensembl chr 7:43,837,660...43,841,879
|
|
| G
|
Klk1b27
|
kallikrein 1-related peptidase b27
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of KLK1B27 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:43,701,714...43,706,136
Ensembl chr 7:43,701,714...43,706,136
|
|
| G
|
Klk6
|
kallikrein related-peptidase 6
|
increases expression
|
ISO
|
lead acetate results in increased expression of KLK6 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:43,473,967...43,481,219
Ensembl chr 7:43,473,923...43,481,454
|
|
| G
|
Klra16
|
killer cell lectin-like receptor, subfamily A, member 16
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of KLRA16 mRNA
|
CTD |
PMID:22609695 |
|
|
|
| G
|
Klra7
|
killer cell lectin-like receptor, subfamily A, member 7
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of KLRA7 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:130,195,568...130,210,285
Ensembl chr 6:130,195,568...130,210,285
|
|
| G
|
Klrb1f
|
killer cell lectin-like receptor subfamily B member 1F
|
increases expression
|
EXP
|
lead acetate results in increased expression of KLRB1F mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:129,022,800...129,036,687
Ensembl chr 6:129,022,864...129,034,427
|
|
| G
|
Kng1
|
kininogen 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of KNG1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828
|
|
| G
|
Kpna2
|
karyopherin subunit alpha 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of KPNA2 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr11:106,879,455...106,890,351
Ensembl chr11:106,879,455...106,890,367
|
|
| G
|
Kpna4
|
karyopherin subunit alpha 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of KPNA4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:68,979,554...69,034,425
Ensembl chr 3:68,974,482...69,034,446
|
|
| G
|
Kras
|
Kirsten rat sarcoma viral oncogene homolog
|
decreases expression multiple interactions increases expression
|
EXP ISO
|
lead acetate results in decreased expression of KRAS mRNA [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of KRAS mRNA lead acetate results in increased expression of KRAS mRNA
|
CTD |
PMID:21829687 PMID:22839698 PMID:25270620 |
|
NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965
|
|
| G
|
Krt15
|
keratin 15
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of KRT15 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:100,022,585...100,026,775
Ensembl chr11:100,022,584...100,026,754
|
|
| G
|
Krt17
|
keratin 17
|
increases expression
|
ISO
|
lead acetate results in increased expression of KRT17 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:100,147,041...100,151,855
Ensembl chr11:100,147,043...100,151,855
|
|
| G
|
Krt18
|
keratin 18
|
affects expression
|
ISO
|
lead acetate affects the expression of KRT18 protein
|
CTD |
PMID:36539177 |
|
NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
|
|
| G
|
Krt80
|
keratin 80
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of KRT80 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:101,246,196...101,268,043
Ensembl chr15:101,245,325...101,268,043
|
|
| G
|
Ky
|
kyphoscoliosis peptidase
|
increases expression
|
EXP
|
lead acetate results in increased expression of KY mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 9:102,382,954...102,423,443
Ensembl chr 9:102,382,949...102,423,438
|
|
| G
|
L3mbtl1
|
L3MBTL1 histone methyl-lysine binding protein
|
increases expression
|
ISO
|
lead acetate results in increased expression of L3MBTL1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:162,784,260...162,819,726
Ensembl chr 2:162,785,392...162,816,442
|
|
| G
|
Lacc1
|
laccase domain containing 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of LACC1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:77,261,640...77,274,344
Ensembl chr14:77,261,640...77,274,344
|
|
| G
|
Lair1
|
leukocyte-associated Ig-like receptor 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LAIR1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:4,010,072...4,076,566
Ensembl chr 7:4,006,401...4,066,178
|
|
| G
|
Lama1
|
laminin, alpha 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of LAMA1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr17:68,004,129...68,129,640
Ensembl chr17:68,004,254...68,129,642
|
|
| G
|
Lama2
|
laminin, alpha 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of LAMA2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr10:26,857,281...27,493,021
Ensembl chr10:26,856,032...27,495,754
|
|
| G
|
Lama3
|
laminin, alpha 3
|
affects expression decreases expression
|
ISO EXP
|
lead acetate affects the expression of LAMA3 mRNA lead acetate results in decreased expression of LAMA3 mRNA
|
CTD |
PMID:21864555 PMID:22609695 |
|
NCBI chr18:12,466,806...12,716,070
Ensembl chr18:12,466,876...12,716,070
|
|
| G
|
Lama5
|
laminin, alpha 5
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of LAMA5 mRNA lead acetate results in decreased expression of LAMA5 mRNA
|
CTD |
PMID:22609695 PMID:38568856 |
|
NCBI chr 2:179,818,166...179,867,652
Ensembl chr 2:179,818,166...179,867,652
|
|
| G
|
Lamb1
|
laminin B1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LAMB1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:31,315,230...31,379,643
Ensembl chr12:31,315,233...31,379,643
|
|
| G
|
Lamb3
|
laminin, beta 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of LAMB3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:192,976,661...193,026,186
Ensembl chr 1:192,890,007...193,026,186
|
|
| G
|
Lamp1
|
lysosomal-associated membrane protein 1
|
decreases expression increases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of LAMP1 protein lead acetate results in increased expression of LAMP1 mRNA (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [lead acetate results in decreased expression of LAMP1 protein]
|
CTD |
PMID:34842334 PMID:38568856 |
|
NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338
|
|
| G
|
Lamp2
|
lysosomal-associated membrane protein 2
|
multiple interactions
|
EXP ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of LAMP2 mRNA
|
CTD |
PMID:33445541 PMID:39276841 |
|
NCBI chr X:37,488,524...37,545,337
Ensembl chr X:37,490,234...37,545,331
|
|
| G
|
Laptm5
|
lysosomal-associated protein transmembrane 5
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LAPTM5 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:130,640,627...130,663,459
Ensembl chr 4:130,640,436...130,663,452
|
|
| G
|
Larp1
|
La ribonucleoprotein 1, translational regulator
|
increases expression
|
ISO
|
lead acetate results in increased expression of LARP1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr11:57,899,711...57,952,860
Ensembl chr11:57,899,890...57,952,860
|
|
| G
|
Larp1b
|
La ribonucleoprotein 1B
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of LARP1B mRNA [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LARP1B mRNA
|
CTD |
PMID:21829687 PMID:22839698 |
|
NCBI chr 3:40,904,198...40,994,642
Ensembl chr 3:40,904,263...40,994,669
|
|
| G
|
Lat
|
linker for activation of T cells
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LAT mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:125,962,999...125,968,877
Ensembl chr 7:125,962,996...125,968,742
|
|
| G
|
Lat2
|
linker for activation of T cells family, member 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of LAT2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:134,628,957...134,648,637
Ensembl chr 5:134,628,876...134,643,879
|
|
| G
|
Lbh
|
limb-bud and heart
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LBH mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:73,225,300...73,248,941
Ensembl chr17:73,225,300...73,248,942
|
|
| G
|
Lbp
|
lipopolysaccharide binding protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of LBP mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772
|
|
| G
|
Lce1a1
|
late cornified envelope 1A1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LCE1A1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:92,553,839...92,555,614
Ensembl chr 3:92,553,842...92,555,614
|
|
| G
|
Lce1b
|
late cornified envelope 1B
|
increases expression
|
EXP
|
lead acetate results in increased expression of LCE1B mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:92,562,957...92,564,233
Ensembl chr 3:92,562,957...92,564,233
|
|
| G
|
Lck
|
lymphocyte protein tyrosine kinase
|
increases expression
|
EXP
|
lead acetate results in increased expression of LCK mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434
|
|
| G
|
Lcn2
|
lipocalin 2
|
multiple interactions increases expression decreases expression
|
EXP ISO
|
pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in increased expression of LCN2 mRNA] lead acetate results in decreased expression of LCN2 mRNA
|
CTD |
PMID:22641619 PMID:36539177 |
|
NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
|
|
| G
|
Lcn5
|
lipocalin 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of LCN5 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:25,547,944...25,552,242
Ensembl chr 2:25,547,964...25,551,989
|
|
| G
|
Lcp1
|
lymphocyte cytosolic protein 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of LCP1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr14:75,368,570...75,468,282
Ensembl chr14:75,368,541...75,468,282
|
|
| G
|
Ldah
|
lipid droplet associated hydrolase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LDAH mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr12:8,258,095...8,350,811
Ensembl chr12:8,258,107...8,335,759
|
|
| G
|
Ldb1
|
LIM domain binding 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LDB1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr19:46,019,963...46,036,584
Ensembl chr19:46,020,009...46,033,653
|
|
| G
|
Ldb3
|
LIM domain binding 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LDB3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr14:34,248,656...34,312,276
Ensembl chr14:34,248,560...34,310,639
|
|
| G
|
Ldha
|
lactate dehydrogenase A
|
affects expression multiple interactions decreases expression
|
ISO EXP
|
lead acetate affects the expression of LDHA mRNA [lead acetate results in increased abundance of Lead] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of LDHA mRNA]; [lead acetate results in increased abundance of Lead] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of LDHA protein] lead acetate results in decreased expression of LDHA mRNA
|
CTD |
PMID:21864555 PMID:25270620 PMID:30615929 PMID:38157908 |
|
NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
|
|
| G
|
Ldlr
|
low density lipoprotein receptor
|
decreases expression
|
EXP ISO
|
lead acetate results in decreased expression of LDLR mRNA lead acetate results in decreased expression of LDLR mRNA; lead acetate results in decreased expression of LDLR protein
|
CTD |
PMID:25270620 PMID:29908845 |
|
NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
|
|
| G
|
Ldlrad3
|
low density lipoprotein receptor class A domain containing 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of LDLRAD3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:101,780,546...102,016,805
Ensembl chr 2:101,780,548...102,016,730
|
|
| G
|
Ldlrad4
|
low density lipoprotein receptor class A domain containing 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of LDLRAD4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr18:68,065,345...68,393,621
Ensembl chr18:68,066,328...68,401,701
|
|
| G
|
Leap2
|
liver-expressed antimicrobial peptide 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LEAP2 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr11:53,313,008...53,313,963
Ensembl chr11:53,313,008...53,313,997
|
|
| G
|
Lepr
|
leptin receptor
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LEPR mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
|
|
| G
|
Letmd1
|
LETM1 domain containing 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LETMD1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:100,360,302...100,377,133
Ensembl chr15:100,366,904...100,377,045
|
|
| G
|
Lfng
|
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
|
increases expression
|
ISO
|
lead acetate results in increased expression of LFNG mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:140,593,096...140,601,300
Ensembl chr 5:140,593,075...140,601,300
|
|
| G
|
Lgr5
|
leucine rich repeat containing G protein coupled receptor 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LGR5 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr10:115,286,219...115,423,685
Ensembl chr10:115,286,216...115,423,685
|
|
| G
|
Lhb
|
luteinizing hormone beta
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of LHB protein naringenin inhibits the reaction [lead acetate results in decreased expression of LHB protein]
|
CTD |
PMID:36807407 |
|
NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
|
|
| G
|
Lhfpl3
|
lipoma HMGIC fusion partner-like 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LHFPL3 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 5:22,951,052...23,480,595
Ensembl chr 5:22,951,057...23,480,595
|
|
| G
|
Lhfpl4
|
lipoma HMGIC fusion partner-like protein 4
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LHFPL4 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 6:113,145,048...113,172,345
Ensembl chr 6:113,145,051...113,172,345
|
|
| G
|
Lhx4
|
LIM homeobox protein 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LHX4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:155,573,777...155,627,481
Ensembl chr 1:155,573,777...155,627,430
|
|
| G
|
Lif
|
leukemia inhibitory factor
|
increases methylation increases expression
|
ISO
|
lead acetate results in increased methylation of LIF gene lead acetate results in increased expression of LIF mRNA
|
CTD |
PMID:29571894 PMID:38568856 |
|
NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514
|
|
| G
|
Lig4
|
ligase IV, DNA, ATP-dependent
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LIG4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 8:10,020,020...10,027,680
Ensembl chr 8:10,019,049...10,027,686
|
|
| G
|
Limk1
|
LIM domain kinase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of LIMK1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:134,684,893...134,718,713
Ensembl chr 5:134,684,893...134,717,452
|
|
| G
|
Lims1
|
LIM and senescent cell antigen-like domains 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of LIMS1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:58,159,164...58,260,513
Ensembl chr10:58,159,288...58,260,513
|
|
| G
|
Lims2
|
LIM and senescent cell antigen like domains 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of LIMS2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr18:32,055,346...32,091,673
Ensembl chr18:32,055,343...32,091,672
|
|
| G
|
Lin28a
|
lin-28 homolog A
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of LIN28A gene
|
CTD |
PMID:29571894 |
|
NCBI chr 4:133,730,641...133,746,504
Ensembl chr 4:133,730,641...133,746,152
|
|
| G
|
Lipa
|
lysosomal acid lipase A
|
increases expression
|
EXP
|
lead acetate results in increased expression of LIPA mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:34,469,716...34,504,874
Ensembl chr19:34,469,718...34,504,874
|
|
| G
|
Lman2l
|
lectin, mannose-binding 2-like
|
increases expression
|
EXP
|
lead acetate results in increased expression of LMAN2L mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:36,458,274...36,484,352
Ensembl chr 1:36,458,952...36,484,352
|
|
| G
|
Lmo4
|
LIM domain only 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of LMO4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:143,894,291...143,911,016
Ensembl chr 3:143,894,291...143,910,981
|
|
| G
|
Lnx1
|
ligand of numb-protein X 1
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LNX1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 5:74,753,108...74,865,203
Ensembl chr 5:74,753,108...74,863,573
|
|
| G
|
Lonp1
|
lon peptidase 1, mitochondrial
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of LONP1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of LONP1 protein; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of LONP1 mRNA]; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of LONP1 protein]
|
CTD |
PMID:39547369 |
|
NCBI chr17:56,921,297...56,933,903
Ensembl chr17:56,921,297...56,933,887
|
|
| G
|
Lonrf3
|
LON peptidase N-terminal domain and ring finger 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of LONRF3 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr X:35,592,011...35,630,510
Ensembl chr X:35,592,006...35,625,994
|
|
| G
|
Lox
|
lysyl oxidase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LOX mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939
|
|
| G
|
Loxl3
|
lysyl oxidase-like 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LOXL3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:83,011,186...83,029,547
Ensembl chr 6:83,011,154...83,029,543
|
|
| G
|
Lpar6
|
lysophosphatidic acid receptor 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LPAR6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr14:73,475,331...73,477,798
Ensembl chr14:73,475,335...73,480,734
|
|
| G
|
Lpin1
|
lipin 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LPIN1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:16,585,670...16,697,020
Ensembl chr12:16,585,670...16,696,967
|
|
| G
|
Lpl
|
lipoprotein lipase
|
increases expression
|
EXP
|
lead acetate results in increased expression of LPL mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100
|
|
| G
|
Lpxn
|
leupaxin
|
increases expression
|
ISO
|
lead acetate results in increased expression of LPXN mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:12,773,251...12,811,177
Ensembl chr19:12,773,557...12,811,171
|
|
| G
|
Lrch1
|
leucine-rich repeats and calponin homology (CH) domain containing 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of LRCH1 intron
|
CTD |
PMID:33445541 |
|
NCBI chr14:74,992,113...75,185,447
Ensembl chr14:74,992,115...75,185,316
|
|
| G
|
Lrg1
|
leucine-rich alpha-2-glycoprotein 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LRG1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:56,426,678...56,428,946
Ensembl chr17:56,426,678...56,429,001
|
|
| G
|
Lrig1
|
leucine-rich repeats and immunoglobulin-like domains 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LRIG1 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 6:94,581,510...94,677,205
Ensembl chr 6:94,581,510...94,677,139
|
|
| G
|
Lrit3
|
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LRIT3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:129,577,590...129,597,785
Ensembl chr 3:129,581,530...129,597,679
|
|
| G
|
Lrp1
|
low density lipoprotein receptor-related protein 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of LRP1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of LRP1 protein
|
CTD |
PMID:31730887 |
|
NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017
|
|
| G
|
Lrp4
|
low density lipoprotein receptor-related protein 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of LRP4 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:91,287,794...91,344,246
Ensembl chr 2:91,287,856...91,344,124
|
|
| G
|
Lrp8
|
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
|
increases expression
|
ISO
|
lead acetate results in increased expression of LRP8 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:107,659,337...107,734,037
Ensembl chr 4:107,659,066...107,734,037
|
|
| G
|
Lrpap1
|
low density lipoprotein receptor-related protein associated protein 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of LRPAP1 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 5:35,248,834...35,263,043
Ensembl chr 5:35,248,845...35,263,110
|
|
| G
|
Lrrc23
|
leucine rich repeat containing 23
|
increases expression
|
ISO
|
lead acetate results in increased expression of LRRC23 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 6:124,746,832...124,757,411
Ensembl chr 6:124,746,826...124,756,690
|
|
| G
|
Lrrc43
|
leucine rich repeat containing 43
|
increases expression
|
ISO
|
lead acetate results in increased expression of LRRC43 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:123,627,349...123,646,268
Ensembl chr 5:123,627,368...123,646,268
|
|
| G
|
Lrrc59
|
leucine rich repeat containing 59
|
increases expression
|
ISO
|
lead acetate results in increased expression of LRRC59 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:94,520,603...94,536,049
Ensembl chr11:94,520,593...94,536,042
|
|
| G
|
Lrrcc1
|
leucine rich repeat and coiled-coil domain containing 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LRRCC1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:14,595,512...14,637,718
Ensembl chr 3:14,598,848...14,637,718
|
|
| G
|
Lrriq4
|
leucine-rich repeats and IQ motif containing 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of LRRIQ4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:30,698,636...30,726,583
Ensembl chr 3:30,698,656...30,726,580
|
|
| G
|
Lrrk1
|
leucine-rich repeat kinase 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LRRK1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:65,908,493...66,038,089
Ensembl chr 7:65,876,660...66,038,098
|
|
| G
|
Ltbp2
|
latent transforming growth factor beta binding protein 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of LTBP2 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr12:84,829,986...84,923,581
Ensembl chr12:84,829,986...84,923,306
|
|
| G
|
Ltf
|
lactotransferrin
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LTF mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835
|
|
| G
|
Lum
|
lumican
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of LUM mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr10:97,401,363...97,408,565
Ensembl chr10:97,400,990...97,408,565
|
|
| G
|
Ly6g6c
|
lymphocyte antigen 6 family member G6C
|
increases expression
|
EXP
|
lead acetate results in increased expression of LY6G6C mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:35,286,301...35,289,024
Ensembl chr17:35,284,364...35,289,026
|
|
| G
|
Ly6k
|
lymphocyte antigen 6 family member K
|
increases expression
|
ISO
|
lead acetate results in increased expression of LY6K mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:74,668,723...74,671,817
Ensembl chr15:74,668,723...74,671,835
|
|
| G
|
Ly96
|
lymphocyte antigen 96
|
increases expression
|
EXP
|
lead acetate results in increased expression of LY96 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:16,758,680...16,779,829
Ensembl chr 1:16,758,275...16,779,835
|
|
| G
|
Lypd3
|
Ly6/Plaur domain containing 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of LYPD3 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:24,335,995...24,340,543
Ensembl chr 7:24,335,975...24,340,543
|
|
| G
|
Lyrm1
|
LYR motif containing 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of LYRM1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:119,495,038...119,515,979
Ensembl chr 7:119,495,084...119,556,186
|
|
| G
|
Lyrm7
|
LYR motif containing 7
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of LYRM7 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr11:54,717,692...54,751,738
Ensembl chr11:54,717,692...54,751,742
|
|
| G
|
Lyve1
|
lymphatic vessel endothelial hyaluronan receptor 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of LYVE1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:110,449,814...110,462,160
Ensembl chr 7:110,449,814...110,462,446
|
|
| G
|
Mab21l1
|
mab-21-like 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MAB21L1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:55,689,931...55,692,708
Ensembl chr 3:55,689,931...55,692,422
|
|
| G
|
Macf1
|
microtubule-actin crosslinking factor 1
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of MACF1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 4:123,243,386...123,581,594
Ensembl chr 4:123,243,426...123,581,331
|
|
| G
|
Maea
|
macrophage erythroblast attacher
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MAEA mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:33,492,916...33,530,638
Ensembl chr 5:33,492,853...33,530,640
|
|
| G
|
Mafb
|
MAF bZIP transcription factor B
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MAFB mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:160,205,597...160,208,985
Ensembl chr 2:160,205,623...160,208,985
|
|
| G
|
Mafg
|
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
|
increases expression
|
ISO
|
lead acetate results in increased expression of MAFG mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426
|
|
| G
|
Mag
|
myelin-associated glycoprotein
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of MAG mRNA [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] affects the expression of MAG protein
|
CTD |
PMID:11578147 PMID:23680456 |
|
NCBI chr 7:30,598,600...30,614,347
Ensembl chr 7:30,598,601...30,614,298
|
|
| G
|
Mageb1
|
MAGE family member B1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MAGEB1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr X:91,058,797...91,059,939
Ensembl chr X:91,058,797...91,059,939
|
|
| G
|
Magoh
|
mago homolog, exon junction complex core component
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MAGOH mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:107,736,952...107,744,621
Ensembl chr 4:107,736,952...107,744,621
|
|
| G
|
Mak
|
male germ cell-associated kinase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MAK mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr13:41,178,483...41,233,182
Ensembl chr13:41,178,484...41,233,182
|
|
| G
|
Mal2
|
mal, T cell differentiation protein 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MAL2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:54,434,762...54,466,242
Ensembl chr15:54,434,588...54,466,243
|
|
| G
|
Malat1
|
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
|
increases expression
|
EXP
|
lead acetate results in increased expression of MALAT1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:5,845,718...5,852,700
Ensembl chr19:5,845,717...5,853,602
|
|
| G
|
Mamdc2
|
MAM domain containing 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of MAMDC2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr19:23,279,973...23,425,855
Ensembl chr19:23,279,973...23,425,806
|
|
| G
|
Man1b1
|
mannosidase, alpha, class 1B, member 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of MAN1B1 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 2:25,222,742...25,242,225
Ensembl chr 2:25,222,350...25,242,224
|
|
| G
|
Manf
|
mesencephalic astrocyte-derived neurotrophic factor
|
increases expression
|
ISO
|
lead acetate results in increased expression of MANF mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:106,765,952...106,769,137
Ensembl chr 9:106,715,511...106,769,178
|
|
| G
|
Map1a
|
microtubule-associated protein 1 A
|
increases expression
|
ISO
|
lead acetate results in increased expression of MAP1A mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 2:121,119,608...121,141,313
Ensembl chr 2:121,120,081...121,141,313
|
|
| G
|
Map1b
|
microtubule-associated protein 1B
|
increases expression
|
ISO
|
lead acetate results in increased expression of MAP1B mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:99,557,972...99,653,110
Ensembl chr13:99,557,954...99,653,048
|
|
| G
|
Map1lc3b
|
microtubule-associated protein 1 light chain 3 beta
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of MAP1LC3B mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of MAP1LC3B protein; [lead acetate results in increased abundance of Lead] which results in increased lipidation of MAP1LC3B protein
|
CTD |
PMID:36652739 PMID:36840722 |
|
NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
|
|
| G
|
Map2
|
microtubule-associated protein 2
|
decreases expression multiple interactions increases expression
|
EXP ISO
|
lead acetate results in decreased expression of MAP2 mRNA PANX2 protein inhibits the reaction [lead acetate results in increased expression of MAP2 mRNA]
|
CTD |
PMID:22013134 PMID:37939567 |
|
NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742
|
|
| G
|
Map2k1
|
mitogen-activated protein kinase kinase 1
|
multiple interactions
|
ISO
|
bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; lead acetate results in increased phosphorylation of and results in increased activity of MAP2K1 protein; Tetradecanoylphorbol Acetate inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K1 protein]
|
CTD |
PMID:11861786 |
|
NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
|
|
| G
|
Map2k2
|
mitogen-activated protein kinase kinase 2
|
multiple interactions
|
ISO
|
bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K2 protein]; lead acetate results in increased phosphorylation of and results in increased activity of MAP2K2 protein; Tetradecanoylphorbol Acetate inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAP2K2 protein]
|
CTD |
PMID:11861786 |
|
NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809
|
|
| G
|
Map2k6
|
mitogen-activated protein kinase kinase 6
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAP2K6 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr11:110,289,928...110,416,348
Ensembl chr11:110,289,948...110,416,348
|
|
| G
|
Map3k5
|
mitogen-activated protein kinase kinase kinase 5
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of MAP3K5 mRNA
|
CTD |
PMID:36642386 |
|
NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499
|
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| G
|
Map4k4
|
mitogen-activated protein kinase kinase kinase kinase 4
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of MAP4K4 mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr 1:39,939,806...40,065,470
Ensembl chr 1:39,940,073...40,065,470
|
|
| G
|
Map4k5
|
mitogen-activated protein kinase kinase kinase kinase 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of MAP4K5 mRNA
|
CTD |
PMID:21322097 |
|
NCBI chr12:69,850,531...69,939,937
Ensembl chr12:69,850,524...69,939,974
|
|
| G
|
Map6d1
|
MAP6 domain containing 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of MAP6D1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr16:20,052,059...20,060,108
Ensembl chr16:20,052,053...20,060,108
|
|
| G
|
Map7d1
|
MAP7 domain containing 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of MAP7D1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:126,125,960...126,150,112
Ensembl chr 4:126,125,960...126,150,136
|
|
| G
|
Mapk1
|
mitogen-activated protein kinase 1
|
multiple interactions increases expression increases phosphorylation affects expression decreases phosphorylation increases oxidation
|
ISO EXP
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; [E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK1 protein modified form]] which results in decreased phosphorylation of MAPK1 protein modified form; [lead acetate results in decreased expression of PRKCA protein] inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; APEX1 protein promotes the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; E 3330 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK1 protein modified form]; E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK1 protein]; HRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; lead acetate promotes the reaction [APEX1 protein results in increased phosphorylation of MAPK1 protein]; lead acetate promotes the reaction [MAPK1 protein modified form binds to APEX1 protein]; lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein] lead acetate results in increased expression of MAPK1 mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK1 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of MAPK1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of MAPK1 protein; Ascorbic Acid inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; lead acetate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Quercetin inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein] lead acetate affects the expression of MAPK1 3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [lead acetate results in increased phosphorylation of MAPK1 protein] lead acetate results in decreased phosphorylation of MAPK1 protein lead acetate results in increased oxidation of MAPK1 protein; lead acetate results in increased oxidation of MAPK1 protein modified form
|
CTD |
PMID:11233754 PMID:11861786 PMID:15302094 PMID:17298174 PMID:19133285 PMID:20829427 PMID:22728154 PMID:23370007 PMID:23765435 PMID:23855546 PMID:24293362 PMID:24530660 PMID:25981801 PMID:26542248 PMID:26797587 PMID:26926986 PMID:33862172 PMID:34350654 PMID:35307918 PMID:37385299 PMID:39276841 More...
|
|
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
|
|
| G
|
Mapk10
|
mitogen-activated protein kinase 10
|
affects expression
|
ISO
|
lead acetate affects the expression of MAPK10
|
CTD |
PMID:24293362 |
|
NCBI chr 5:103,056,413...103,359,200
Ensembl chr 5:103,055,814...103,359,200
|
|
| G
|
Mapk11
|
mitogen-activated protein kinase 11
|
affects expression increases expression
|
ISO EXP
|
lead acetate affects the expression of MAPK11 lead acetate results in increased expression of MAPK11 mRNA
|
CTD |
PMID:21322097 PMID:24293362 |
|
NCBI chr15:89,026,685...89,033,809
Ensembl chr15:89,026,689...89,033,831
|
|
| G
|
Mapk14
|
mitogen-activated protein kinase 14
|
affects expression increases expression multiple interactions
|
ISO
|
lead acetate affects the expression of MAPK14 lead acetate results in increased expression of MAPK14 mRNA sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK14 mRNA]
|
CTD |
PMID:24293362 PMID:37471654 |
|
NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
|
|
| G
|
Mapk15
|
mitogen-activated protein kinase 15
|
multiple interactions increases expression
|
ISO
|
sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK15 mRNA]
|
CTD |
PMID:37471654 |
|
NCBI chr15:75,865,581...75,871,002
Ensembl chr15:75,865,618...75,871,003
|
|
| G
|
Mapk3
|
mitogen-activated protein kinase 3
|
multiple interactions increases phosphorylation affects expression decreases phosphorylation increases oxidation
|
ISO EXP
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; [E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK3 protein modified form]] which results in decreased phosphorylation of MAPK3 protein modified form; [lead acetate results in decreased expression of PRKCA protein] inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; APEX1 protein promotes the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; bisindolylmaleimide I inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; E 3330 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK3 protein modified form]; E 3330 promotes the reaction [lead acetate results in increased oxidation of MAPK3 protein]; HRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; lead acetate promotes the reaction [APEX1 protein results in increased phosphorylation of MAPK3 protein]; lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein; RTKI cpd inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK3 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of MAPK3 mRNA; [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of MAPK3 protein; Ascorbic Acid inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein]; lead acetate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Quercetin inhibits the reaction [lead acetate results in increased phosphorylation of MAPK3 protein] lead acetate affects the expression of MAPK3 lead acetate results in decreased phosphorylation of MAPK3 protein lead acetate results in increased oxidation of MAPK3 protein; lead acetate results in increased oxidation of MAPK3 protein modified form
|
CTD |
PMID:11233754 PMID:11861786 PMID:15302094 PMID:17298174 PMID:19133285 PMID:20829427 PMID:22728154 PMID:23370007 PMID:23765435 PMID:23855546 PMID:24293362 PMID:24530660 PMID:25981801 PMID:26542248 PMID:26797587 PMID:26926986 PMID:34350654 PMID:35307918 PMID:39276841 More...
|
|
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
|
|
| G
|
Mapk4
|
mitogen-activated protein kinase 4
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAPK4 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr18:74,061,557...74,198,643
Ensembl chr18:74,061,557...74,198,430
|
|
| G
|
Mapk6
|
mitogen-activated protein kinase 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of MAPK6 mRNA
|
CTD |
PMID:21322097 |
|
NCBI chr 9:75,294,064...75,317,303
Ensembl chr 9:75,276,344...75,317,287
|
|
| G
|
Mapk7
|
mitogen-activated protein kinase 7
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of MAPK7 protein
|
CTD |
PMID:39947421 |
|
NCBI chr11:61,379,638...61,385,101
Ensembl chr11:61,379,638...61,385,232
|
|
| G
|
Mapk8
|
mitogen-activated protein kinase 8
|
increases expression multiple interactions affects expression increases phosphorylation
|
ISO
|
lead acetate results in increased expression of MAPK8 mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK8 protein]; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK8 protein; [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of MAPK8 protein; Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPK8 protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of MAPK8 mRNA] lead acetate affects the expression of MAPK8
|
CTD |
PMID:20829427 PMID:24293362 PMID:25088297 PMID:35307918 PMID:37471654 |
|
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
|
|
| G
|
Mapk9
|
mitogen-activated protein kinase 9
|
multiple interactions increases phosphorylation
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MAPK9 mRNA lead acetate results in increased phosphorylation of MAPK9 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK9 protein]; [Cadmium Chloride co-treated with sodium arsenite co-treated with lead acetate] results in increased phosphorylation of MAPK9 protein; Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPK9 protein]
|
CTD |
PMID:12634122 PMID:20829427 PMID:25088297 |
|
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
|
|
| G
|
Mapkapk2
|
MAP kinase-activated protein kinase 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of MAPKAPK2 mRNA
|
CTD |
PMID:21322097 |
|
NCBI chr 1:130,981,437...131,025,580
Ensembl chr 1:130,981,437...131,025,563
|
|
| G
|
Mapre2
|
microtubule-associated protein, RP/EB family, member 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of MAPRE2 protein
|
CTD |
PMID:38072110 |
|
NCBI chr18:23,885,390...24,026,918
Ensembl chr18:23,885,390...24,026,918
|
|
| G
|
Mapt
|
microtubule-associated protein tau
|
increases expression multiple interactions increases phosphorylation
|
EXP ISO
|
lead acetate results in increased expression of MAPT mRNA lead acetate results in increased expression of and results in increased phosphorylation of MAPT protein lead acetate results in decreased expression of and results in increased phosphorylation of MAPT protein; lead acetate results in increased expression of and results in increased phosphorylation of MAPT protein; Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of MAPT protein] [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of MAPT protein; lead acetate affects the reaction [MAPT protein affects the abundance of CDK5R1 protein modified form]; lead acetate results in increased expression of and results in increased phosphorylation of MAPT protein
|
CTD |
PMID:22811615 PMID:23134599 PMID:24954411 PMID:25088297 PMID:27012722 PMID:27293183 PMID:29203278 PMID:31730887 PMID:32058320 More...
|
|
NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
|
|
| G
|
Marchf7
|
membrane associated ring-CH-type finger 7
|
increases expression
|
EXP
|
lead acetate results in increased expression of MARCHF7 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:60,040,086...60,079,555
Ensembl chr 2:60,040,231...60,081,020
|
|
| G
|
Marcks
|
myristoylated alanine rich protein kinase C substrate
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MARCKS mRNA; lead acetate results in decreased expression of MARCKS protein
|
CTD |
PMID:11578147 |
|
NCBI chr10:37,009,239...37,014,922
Ensembl chr10:37,009,371...37,014,916
|
|
| G
|
Marcksl1
|
MARCKS-like 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MARCKSL1 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 4:129,407,374...129,409,774
Ensembl chr 4:129,407,374...129,409,778
|
|
| G
|
Mark2
|
MAP/microtubule affinity regulating kinase 2
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of MARK2 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr19:7,252,761...7,319,222
Ensembl chr19:7,252,761...7,319,225
|
|
| G
|
Mars1
|
methionine-tRNA synthetase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of MARS1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr10:127,132,090...127,147,655
Ensembl chr10:127,132,090...127,147,655
|
|
| G
|
Masp1
|
MBL associated serine protease 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MASP1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:23,261,778...23,340,127
Ensembl chr16:23,268,167...23,339,565
|
|
| G
|
Mast2
|
microtubule associated serine/threonine kinase 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of MAST2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:116,163,957...116,321,420
Ensembl chr 4:116,163,959...116,321,471
|
|
| G
|
Mastl
|
microtubule associated serine/threonine kinase-like
|
increases expression
|
EXP
|
lead acetate results in increased expression of MASTL mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:23,006,549...23,046,036
Ensembl chr 2:23,005,618...23,046,036
|
|
| G
|
Mat2a
|
methionine adenosyltransferase 2A
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MAT2A mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:72,409,779...72,416,539
Ensembl chr 6:72,409,782...72,416,541
|
|
| G
|
Matk
|
megakaryocyte-associated tyrosine kinase
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MATK mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr10:81,088,769...81,098,819
Ensembl chr10:81,088,769...81,099,199
|
|
| G
|
Mb
|
myoglobin
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MB mRNA
|
CTD |
PMID:22609695 PMID:29746905 |
|
NCBI chr15:76,899,687...76,934,868
Ensembl chr15:76,899,687...76,934,870
|
|
| G
|
Mbd3
|
methyl-CpG binding domain protein 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of MBD3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:80,228,373...80,235,365
Ensembl chr10:80,228,373...80,235,384
|
|
| G
|
Mbd3l2
|
methyl-CpG binding domain protein 3-like 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of MBD3L2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:18,341,911...18,357,612
Ensembl chr 9:18,341,950...18,357,612
|
|
| G
|
Mbd4
|
methyl-CpG binding domain protein 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MBD4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:115,817,658...115,830,361
Ensembl chr 6:115,817,658...115,830,332
|
|
| G
|
Mbp
|
myelin basic protein
|
decreases expression multiple interactions
|
EXP ISO
|
lead acetate results in decreased expression of MBP mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of MBP mRNA [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of MBP protein lead acetate results in decreased expression of MBP protein
|
CTD |
PMID:21829687 PMID:23680456 PMID:32458983 |
|
NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
|
|
| G
|
Mbtd1
|
mbt domain containing 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MBTD1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:93,776,635...93,837,815
Ensembl chr11:93,776,678...93,837,811
|
|
| G
|
Mc4r
|
melanocortin 4 receptor
|
increases expression
|
ISO
|
lead acetate results in increased expression of MC4R mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr18:66,990,776...66,993,558
Ensembl chr18:66,990,775...66,993,577
|
|
| G
|
Mcc
|
mutated in colorectal cancers
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCC mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr18:44,558,127...44,945,573
Ensembl chr18:44,558,127...44,945,249
|
|
| G
|
Mcf2
|
mcf.2 transforming sequence
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MCF2 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr X:59,101,316...59,224,546
Ensembl chr X:59,101,316...59,224,449
|
|
| G
|
Mcm2
|
minichromosome maintenance complex component 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MCM2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762
|
|
| G
|
Mcm8
|
minichromosome maintenance 8 homologous recombination repair factor
|
increases expression
|
ISO
|
lead acetate results in increased expression of MCM8 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:132,658,061...132,686,117
Ensembl chr 2:132,658,061...132,686,117
|
|
| G
|
Mdfic
|
MyoD family inhibitor domain containing
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MDFIC mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:15,720,660...15,802,168
Ensembl chr 6:15,720,660...15,802,168
|
|
| G
|
Mdh2
|
malate dehydrogenase 2, NAD (mitochondrial)
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of MDH2 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 5:135,807,503...135,819,240
Ensembl chr 5:135,807,334...135,819,252
|
|
| G
|
Mdk
|
midkine
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MDK mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 2:91,760,149...91,762,348
Ensembl chr 2:91,760,150...91,762,642
|
|
| G
|
Mdp1
|
magnesium-dependent phosphatase 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MDP1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr14:55,895,346...55,897,908
Ensembl chr14:55,895,336...55,897,965
|
|
| G
|
Me1
|
malic enzyme 1, NADP(+)-dependent, cytosolic
|
increases expression
|
ISO
|
lead acetate results in increased expression of ME1 mRNA
|
CTD |
PMID:22839698 PMID:37939567 PMID:38568856 |
|
NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006
|
|
| G
|
Me2
|
malic enzyme 2, NAD(+)-dependent, mitochondrial
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of ME2 intron
|
CTD |
PMID:33445541 |
|
NCBI chr18:73,898,025...73,949,326
Ensembl chr18:73,902,974...73,948,520
|
|
| G
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Mecp2
|
methyl CpG binding protein 2
|
decreases expression affects expression multiple interactions
|
ISO EXP
|
lead acetate results in decreased expression of MECP2 protein lead acetate affects the expression of MECP2 mRNA [lead acetate results in increased abundance of Lead] which affects the expression of MECP2 protein
|
CTD |
PMID:22160880 PMID:23246732 PMID:29481626 |
|
NCBI chr X:73,070,198...73,129,296
Ensembl chr X:73,070,198...73,129,296
|
|
| G
|
Med10
|
mediator complex subunit 10
|
increases expression
|
ISO
|
lead acetate results in increased expression of MED10 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:69,950,467...69,964,221
Ensembl chr13:69,950,514...69,964,223
|
|
| G
|
Med13l
|
mediator complex subunit 13-like
|
increases expression
|
EXP
|
lead acetate results in increased expression of MED13L mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:118,698,363...118,903,503
Ensembl chr 5:118,698,744...118,903,503
|
|
| G
|
Mef2a
|
myocyte enhancer factor 2A
|
affects expression
|
EXP
|
lead acetate affects the expression of MEF2A mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:66,880,911...67,026,435
Ensembl chr 7:66,880,911...67,022,606
|
|
| G
|
Mef2c
|
myocyte enhancer factor 2C
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of MEF2C protein
|
CTD |
PMID:39947421 |
|
NCBI chr13:83,652,136...83,815,197
Ensembl chr13:83,652,153...83,815,199
|
|
| G
|
Megf9
|
multiple EGF-like-domains 9
|
increases expression
|
ISO
|
lead acetate results in increased expression of MEGF9 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 4:70,350,164...70,453,165
Ensembl chr 4:70,345,302...70,453,232
|
|
| G
|
Meig1
|
meiosis expressed gene 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of MEIG1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of MEIG1 protein
|
CTD |
PMID:32142724 |
|
NCBI chr 2:3,410,080...3,423,685
Ensembl chr 2:3,410,080...3,423,685
|
|
| G
|
Mepe
|
matrix extracellular phosphoglycoprotein with ASARM motif (bone)
|
increases expression
|
EXP
|
lead acetate results in increased expression of MEPE mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:104,473,195...104,486,477
Ensembl chr 5:104,473,195...104,486,477
|
|
| G
|
Mertk
|
MER proto-oncogene tyrosine kinase
|
increases expression
|
ISO
|
lead acetate results in increased expression of MERTK mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:128,540,836...128,645,082
Ensembl chr 2:128,540,876...128,644,814
|
|
| G
|
Mest
|
mesoderm specific transcript
|
increases expression decreases methylation
|
ISO
|
lead acetate results in increased expression of MEST mRNA lead acetate results in decreased methylation of MEST gene
|
CTD |
PMID:25596546 |
|
NCBI chr 6:30,733,505...30,783,580
Ensembl chr 6:30,723,546...30,748,464
|
|
| G
|
Met
|
met proto-oncogene
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MET protein
|
CTD |
PMID:17298174 |
|
NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
|
|
| G
|
Mettl17
|
methyltransferase like 17
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of METTL17 gene
|
CTD |
PMID:29571894 |
|
NCBI chr14:52,122,375...52,129,325
Ensembl chr14:52,122,299...52,130,496
|
|
| G
|
Mettl4
|
methyltransferase 4, N6-adenosine
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of METTL4 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr17:95,030,018...95,057,579
Ensembl chr17:95,030,018...95,057,447
|
|
| G
|
Mfrp
|
membrane frizzled-related protein
|
affects expression
|
ISO
|
lead acetate affects the expression of MFRP mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 9:44,013,067...44,020,484
Ensembl chr 9:44,013,026...44,020,484
|
|
| G
|
Mfsd11
|
major facilitator superfamily domain containing 11
|
increases expression
|
EXP
|
lead acetate results in increased expression of MFSD11 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:116,743,037...116,766,486
Ensembl chr11:116,743,266...116,766,461
|
|
| G
|
Mgst1
|
microsomal glutathione S-transferase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of MGST1 mRNA
|
CTD |
PMID:11578147 PMID:22641619 PMID:37939567 PMID:38568856 |
|
NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753
|
|
| G
|
Mia2
|
MIA SH3 domain ER export factor 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIA2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr12:59,142,368...59,237,006
Ensembl chr12:59,142,585...59,238,369
|
|
| G
|
Mid1
|
midline 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of MID1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr X:168,468,178...168,773,692
Ensembl chr X:168,468,195...168,773,794
|
|
| G
|
Mid1ip1
|
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
|
increases expression
|
ISO
|
lead acetate results in increased expression of MID1IP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr X:10,583,604...10,585,941
Ensembl chr X:10,581,252...10,585,929
|
|
| G
|
Miga2
|
mitoguardin 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIGA2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:30,254,232...30,275,532
Ensembl chr 2:30,254,245...30,275,533
|
|
| G
|
Mink1
|
misshapen-like kinase 1 (zebrafish)
|
increases expression
|
EXP
|
lead acetate results in increased expression of MINK1 mRNA
|
CTD |
PMID:21322097 |
|
NCBI chr11:70,452,272...70,505,309
Ensembl chr11:70,453,707...70,505,309
|
|
| G
|
Mios
|
meiosis regulator for oocyte development
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIOS mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 6:8,209,111...8,240,573
Ensembl chr 6:8,209,222...8,236,274
|
|
| G
|
Miox
|
myo-inositol oxygenase
|
decreases expression increases expression
|
ISO EXP
|
lead acetate results in decreased expression of MIOX mRNA lead acetate results in increased expression of MIOX mRNA
|
CTD |
PMID:22609695 PMID:22641619 |
|
NCBI chr15:89,218,676...89,221,210
Ensembl chr15:89,218,601...89,221,218
|
|
| G
|
Mir100
|
microRNA 100
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR100 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 9:41,442,721...41,442,800
Ensembl chr 9:41,442,721...41,442,800
|
|
| G
|
Mir106b
|
microRNA 106b
|
multiple interactions
|
ISO EXP
|
[lead acetate results in increased abundance of Lead] which results in increased expression of MIR106B mRNA; MIR106B mRNA affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of XIAP protein]
|
CTD |
PMID:32344020 |
|
NCBI chr 5:138,163,999...138,164,080
Ensembl chr 5:138,163,999...138,164,080
|
|
| G
|
Mir1247
|
microRNA 1247
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR1247 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr12:110,244,482...110,244,563
Ensembl chr12:110,244,482...110,244,563
|
|
| G
|
Mir1306
|
microRNA 1306
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR1306 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr16:18,102,103...18,102,181
Ensembl chr16:18,102,103...18,102,181
|
|
| G
|
Mir149
|
microRNA 149
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR149 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 1:92,778,100...92,778,165
Ensembl chr 1:92,778,100...92,778,165
|
|
| G
|
Mir154
|
microRNA 154
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of MIR154 mRNA
|
CTD |
PMID:24080485 |
|
NCBI chr12:109,704,867...109,704,932
Ensembl chr12:109,704,867...109,704,932
|
|
| G
|
Mir194-1
|
microRNA 194-1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR194-1 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 1:185,045,516...185,045,582
Ensembl chr 1:185,045,516...185,045,582
|
|
| G
|
Mir194-2
|
microRNA 194-2
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR194-2 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr19:6,314,673...6,314,758
Ensembl chr19:6,314,673...6,314,758
|
|
| G
|
Mir1b
|
microRNA 1b
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR1B mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr18:10,785,446...10,785,567
Ensembl chr18:10,785,446...10,785,567
|
|
| G
|
Mir202
|
microRNA 202
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR202 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 7:139,537,602...139,537,673
Ensembl chr 7:139,537,602...139,537,673
|
|
| G
|
Mir204
|
microRNA 204
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of MIR204 mRNA
|
CTD |
PMID:24080485 |
|
NCBI chr19:22,727,969...22,728,036
Ensembl chr19:22,727,969...22,728,036
|
|
| G
|
Mir205
|
microRNA 205
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR205 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 1:193,189,771...193,189,838
Ensembl chr 1:193,189,771...193,189,838
|
|
| G
|
Mir206
|
microRNA 206
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR206 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 1:20,749,234...20,749,306
Ensembl chr 1:20,749,234...20,749,306
|
|
| G
|
Mir216a
|
microRNA 216a
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR216A mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr11:28,707,012...28,707,083
Ensembl chr11:28,707,012...28,707,083
|
|
| G
|
Mir221
|
microRNA 221
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR221 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr X:19,012,533...19,012,627
Ensembl chr X:19,012,533...19,012,627
|
|
| G
|
Mir222
|
microRNA 222
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of MIR222 mRNA
|
CTD |
PMID:24080485 |
|
NCBI chr X:19,013,132...19,013,210
Ensembl chr X:19,013,132...19,013,210
|
|
| G
|
Mir27b
|
microRNA 27b
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of MIR27B mRNA
|
CTD |
PMID:24080485 |
|
NCBI chr13:63,448,526...63,448,598
Ensembl chr13:63,448,526...63,448,598
|
|
| G
|
Mir3065
|
microRNA 3065
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR3065 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr11:119,905,593...119,905,679
Ensembl chr11:119,905,593...119,905,679
|
|
| G
|
Mir30c-1
|
microRNA 30c-1
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR30C-1 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 4:120,626,731...120,626,819
Ensembl chr 4:120,626,731...120,626,819
|
|
| G
|
Mir3107
|
microRNA 3107
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR3107 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 8:23,632,589...23,632,678
Ensembl chr 8:23,632,589...23,632,678
|
|
| G
|
Mir330
|
microRNA 330
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR330 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 7:18,915,390...18,915,487
Ensembl chr 7:18,915,390...18,915,487
|
|
| G
|
Mir338
|
microRNA 338
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR338 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr11:119,905,591...119,905,688
Ensembl chr11:119,905,591...119,905,688
|
|
| G
|
Mir339
|
microRNA 339
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR339 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 5:139,355,405...139,355,500
Ensembl chr 5:139,355,405...139,355,500
|
|
| G
|
Mir34b
|
microRNA 34b
|
multiple interactions
|
EXP ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of MIR34B mRNA [[lead acetate results in increased abundance of Lead] which results in increased expression of MIR34B mRNA] which results in decreased expression of VAMP2 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of MIR34B mRNA
|
CTD |
PMID:35367965 |
|
NCBI chr 9:51,014,862...51,014,945
Ensembl chr 9:51,014,862...51,014,945
|
|
| G
|
Mir34c
|
microRNA 34c
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR34C mRNA
|
CTD |
PMID:27293183 |
|
NCBI chr 9:51,014,334...51,014,410
Ensembl chr 9:51,014,334...51,014,410
|
|
| G
|
Mir363
|
microRNA 363
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR363 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr X:51,830,570...51,830,644
Ensembl chr X:51,830,570...51,830,644
|
|
| G
|
Mir375
|
microRNA 375
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of MIR375 mRNA
|
CTD |
PMID:24080485 |
|
NCBI chr 1:74,939,817...74,939,880
Ensembl chr 1:74,939,817...74,939,880
|
|
| G
|
Mir376c
|
microRNA 376c
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of MIR376C mRNA
|
CTD |
PMID:24080485 |
|
NCBI chr12:109,689,152...109,689,237
Ensembl chr12:109,689,152...109,689,237
|
|
| G
|
Mir379
|
microRNA 379
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of MIR379 mRNA
|
CTD |
PMID:24080485 |
|
NCBI chr12:109,675,494...109,675,559
Ensembl chr12:109,675,494...109,675,559
|
|
| G
|
Mir382
|
microRNA 382
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR382 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr12:109,700,205...109,700,280
Ensembl chr12:109,700,205...109,700,280
|
|
| G
|
Mir451a
|
microRNA 451a
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR451A mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr11:77,963,996...77,964,067
Ensembl chr11:77,963,996...77,964,067
|
|
| G
|
Mir466h
|
microRNA 466h
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR466H mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 2:10,519,702...10,519,782
Ensembl chr 2:10,519,702...10,519,782
|
|
| G
|
Mir466i
|
microRNA 466i
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR466I mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr13:17,922,058...17,922,178
Ensembl chr13:17,922,058...17,922,178
|
|
| G
|
Mir467c
|
microRNA 467c
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR467C mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 2:10,478,742...10,478,838
Ensembl chr 2:10,478,742...10,478,838
|
|
| G
|
Mir467d
|
microRNA 467d
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR467D mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 2:10,512,441...10,512,525
Ensembl chr 2:10,512,441...10,512,525
|
|
| G
|
Mir485
|
microRNA 485
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR485 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr12:109,701,336...109,701,408
Ensembl chr12:109,701,336...109,701,408
|
|
| G
|
Mir486
|
microRNA 486
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR486 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 8:23,632,571...23,632,698
Ensembl chr 8:23,632,571...23,632,698
|
|
| G
|
Mir488
|
microRNA 488
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR488 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 1:158,333,195...158,333,303
Ensembl chr 1:158,333,195...158,333,303
|
|
| G
|
Mir543
|
microRNA 543
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR543 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr12:109,683,692...109,683,767
Ensembl chr12:109,683,692...109,683,767
|
|
| G
|
Mir574
|
microRNA 574
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR574 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 5:65,127,661...65,127,738
Ensembl chr 5:65,127,661...65,127,738
|
|
| G
|
Mir664
|
microRNA 664
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR664 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 1:184,975,172...184,975,240
Ensembl chr 1:184,975,172...184,975,240
|
|
| G
|
Mir671
|
microRNA 671
|
decreases expression multiple interactions
|
EXP
|
lead acetate results in decreased expression of MIR671 mRNA MIR671 mRNA inhibits the reaction [lead acetate results in increased expression of CASP3 protein]; MIR671 mRNA inhibits the reaction [lead acetate results in increased expression of CASP9 protein]
|
CTD |
PMID:27604105 |
|
NCBI chr 5:24,797,112...24,797,209
Ensembl chr 5:24,797,112...24,797,209
|
|
| G
|
Mir674
|
microRNA 674
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR674 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 2:117,015,608...117,015,707
Ensembl chr 2:117,015,608...117,015,707
|
|
| G
|
Mir704
|
microRNA 704
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR704 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 6:47,780,510...47,780,586
Ensembl chr 6:47,780,510...47,780,586
|
|
| G
|
Mir7213
|
microRNA 7213
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of MIR7213 promoter
|
CTD |
PMID:33445541 |
|
NCBI chr15:79,883,171...79,883,227
Ensembl chr15:79,883,171...79,883,227
|
|
| G
|
Mir7b
|
microRNA 7b
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIR7B mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr17:56,549,988...56,550,098
Ensembl chr17:56,549,988...56,550,098
|
|
| G
|
Mir883b
|
microRNA 883b
|
increases expression
|
EXP
|
lead acetate results in increased expression of MIR883B mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr X:65,833,496...65,833,573
Ensembl chr X:65,833,496...65,833,573
|
|
| G
|
Mirlet7c-1
|
microRNA let7c-1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MIRLET7C-1 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr16:77,396,545...77,396,638
Ensembl chr16:77,396,545...77,396,638
|
|
| G
|
Mis18a
|
MIS18 kinetochore protein A
|
affects expression
|
ISO
|
lead acetate affects the expression of MIS18A mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr16:90,516,200...90,524,259
Ensembl chr16:90,516,200...90,524,292
|
|
| G
|
Mitf
|
melanogenesis associated transcription factor
|
increases expression
|
EXP
|
lead acetate results in increased expression of MITF mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 6:97,783,966...97,998,321
Ensembl chr 6:97,784,013...97,998,310
|
|
| G
|
Mki67
|
antigen identified by monoclonal antibody Ki 67
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of MKI67 protein; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of MKI67 protein]
|
CTD |
PMID:33978298 |
|
NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
|
|
| G
|
Mknk2
|
MAP kinase-interacting serine/threonine kinase 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MKNK2 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr10:80,501,152...80,512,264
Ensembl chr10:80,501,161...80,513,946
|
|
| G
|
Mlec
|
malectin
|
increases expression
|
EXP
|
lead acetate results in increased expression of MLEC mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:115,281,040...115,296,235
Ensembl chr 5:115,281,040...115,296,238
|
|
| G
|
Mlf1
|
myeloid leukemia factor 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MLF1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:67,281,430...67,307,333
Ensembl chr 3:67,281,430...67,307,336
|
|
| G
|
Mllt1
|
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of MLLT1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:57,199,611...57,242,497
Ensembl chr17:57,198,385...57,242,415
|
|
| G
|
Mllt11
|
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11
|
increases expression
|
ISO
|
lead acetate results in increased expression of MLLT11 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:95,125,852...95,139,486
Ensembl chr 3:95,126,446...95,139,482
|
|
| G
|
Mllt3
|
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of MLLT3 mRNA [lead acetate co-treated with zinc protoporphyrin] results in increased expression of MLLT3 mRNA
|
CTD |
PMID:21829687 PMID:22839698 |
|
NCBI chr 4:87,688,162...87,951,652
Ensembl chr 4:87,688,162...87,951,601
|
|
| G
|
Mlph
|
melanophilin
|
increases expression
|
ISO
|
lead acetate results in increased expression of MLPH mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:90,842,750...90,878,864
Ensembl chr 1:90,842,807...90,878,864
|
|
| G
|
Mlxip
|
MLX interacting protein
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MLXIP mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:123,532,438...123,595,998
Ensembl chr 5:123,532,861...123,595,995
|
|
| G
|
Mmp14
|
matrix metallopeptidase 14 (membrane-inserted)
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of MMP14 mRNA lead acetate results in increased expression of MMP14 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821
|
|
| G
|
Mmp19
|
matrix metallopeptidase 19
|
increases expression
|
EXP
|
lead acetate results in increased expression of MMP19 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr10:128,626,779...128,636,696
Ensembl chr10:128,626,779...128,636,693
|
|
| G
|
Mmp2
|
matrix metallopeptidase 2
|
affects expression
|
ISO
|
lead acetate affects the expression of MMP2 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
|
|
| G
|
Mmp25
|
matrix metallopeptidase 25
|
increases expression
|
EXP
|
lead acetate results in increased expression of MMP25 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr17:23,847,289...23,864,006
Ensembl chr17:23,847,285...23,864,251
|
|
| G
|
Mmp28
|
matrix metallopeptidase 28 (epilysin)
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MMP28 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:83,331,594...83,353,890
Ensembl chr11:83,331,594...83,353,897
|
|
| G
|
Mmp3
|
matrix metallopeptidase 3
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of MMP3 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
|
|
| G
|
Mmp9
|
matrix metallopeptidase 9
|
increases expression
|
EXP
|
lead acetate results in increased expression of MMP9 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
|
|
| G
|
Mocos
|
molybdenum cofactor sulfurase
|
increases expression
|
EXP
|
lead acetate results in increased expression of MOCOS mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr18:24,786,538...24,834,634
Ensembl chr18:24,786,748...24,834,632
|
|
| G
|
Mogat2
|
monoacylglycerol O-acyltransferase 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of MOGAT2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:98,868,291...98,887,818
Ensembl chr 7:98,868,291...98,887,826
|
|
| G
|
Morf4l2
|
mortality factor 4 like 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MORF4L2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr X:135,633,691...135,644,435
Ensembl chr X:135,633,691...135,644,439
|
|
| G
|
Mos
|
Moloney sarcoma oncogene
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MOS mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:3,870,658...3,872,105
Ensembl chr 4:3,870,657...3,872,105
|
|
| G
|
Mospd1
|
motile sperm domain containing 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MOSPD1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr X:52,433,471...52,459,567
Ensembl chr X:52,433,475...52,459,379
|
|
| G
|
Mov10
|
Mov10 RISC complex RNA helicase
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MOV10 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr 3:104,702,144...104,725,935
Ensembl chr 3:104,702,152...104,725,879
|
|
| G
|
Mpeg1
|
macrophage expressed gene 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of MPEG1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:12,438,134...12,442,649
Ensembl chr19:12,438,143...12,442,649
|
|
| G
|
Mphosph6
|
M phase phosphoprotein 6
|
increases expression
|
ISO
|
lead acetate results in increased expression of MPHOSPH6 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:118,518,376...118,528,713
Ensembl chr 8:118,518,384...118,528,682
|
|
| G
|
Mpo
|
myeloperoxidase
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of MPO protein 3-methyladenine inhibits the reaction [lead acetate results in increased expression of MPO protein]
|
CTD |
PMID:32879255 |
|
NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
|
|
| G
|
Mprip
|
myosin phosphatase Rho interacting protein
|
increases expression
|
ISO
|
lead acetate results in increased expression of MPRIP mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:59,552,973...59,671,686
Ensembl chr11:59,552,131...59,671,686
|
|
| G
|
Mrc1
|
mannose receptor, C type 1
|
increases expression multiple interactions
|
ISO EXP
|
lead acetate results in increased expression of MRC1 mRNA [lead acetate results in increased abundance of Lead] promotes the reaction [[IL4 protein co-treated with IFNG protein] results in increased expression of MRC1 protein]
|
CTD |
PMID:22641619 PMID:34352350 |
|
NCBI chr 2:14,234,225...14,336,834
Ensembl chr 2:14,234,203...14,336,868
|
|
| G
|
Mrc2
|
mannose receptor, C type 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MRC2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:105,183,440...105,241,971
Ensembl chr11:105,183,469...105,241,965
|
|
| G
|
Mrpl11
|
mitochondrial ribosomal protein L11
|
increases expression
|
EXP
|
lead acetate results in increased expression of MRPL11 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr19:5,012,180...5,017,023
Ensembl chr19:5,012,175...5,017,027
|
|
| G
|
Mrpl19
|
mitochondrial ribosomal protein L19
|
increases expression
|
EXP
|
lead acetate results in increased expression of MRPL19 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:81,934,807...81,942,930
Ensembl chr 6:81,934,832...81,942,939
|
|
| G
|
Mrpl21
|
mitochondrial ribosomal protein L21
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of MRPL21 protein
|
CTD |
PMID:38072110 |
|
NCBI chr19:3,332,997...3,342,837
Ensembl chr19:3,332,901...3,342,837
|
|
| G
|
Mrpl3
|
mitochondrial ribosomal protein L3
|
increases expression
|
EXP
|
lead acetate results in increased expression of MRPL3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:104,930,394...104,954,665
Ensembl chr 9:104,930,438...104,957,087
|
|
| G
|
Mrpl41
|
mitochondrial ribosomal protein L41
|
increases expression
|
ISO
|
lead acetate results in increased expression of MRPL41 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:24,862,482...24,865,110
Ensembl chr 2:24,864,129...24,865,110
|
|
| G
|
Mrps12
|
mitochondrial ribosomal protein S12
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MRPS12 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 7:28,439,066...28,441,246
Ensembl chr 7:28,439,066...28,441,245
|
|
| G
|
Mrps27
|
mitochondrial ribosomal protein S27
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MRPS27 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:99,481,275...99,552,070
Ensembl chr13:99,481,294...99,552,070
|
|
| G
|
Mrps33
|
mitochondrial ribosomal protein S33
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MRPS33 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:39,778,738...39,787,870
Ensembl chr 6:39,778,738...39,787,922
|
|
| G
|
Mrps6
|
mitochondrial ribosomal protein S6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MRPS6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr16:91,855,224...91,909,115
Ensembl chr16:91,855,158...91,909,115
|
|
| G
|
Msgn1
|
mesogenin 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MSGN1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr12:11,258,383...11,258,949
Ensembl chr12:11,258,361...11,258,973
|
|
| G
|
Msh2
|
mutS homolog 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MSH2 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141
|
|
| G
|
Msh5
|
mutS homolog 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MSH5 mRNA
|
CTD |
PMID:22609695 PMID:22613225 |
|
NCBI chr17:35,247,581...35,267,842
Ensembl chr17:35,247,581...35,265,721
|
|
| G
|
Msi2
|
musashi RNA-binding protein 2
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of MSI2 intron
|
CTD |
PMID:33445541 |
|
NCBI chr11:88,230,208...88,609,197
Ensembl chr11:88,230,208...88,609,339
|
|
| G
|
Msln
|
mesothelin
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MSLN mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:25,967,587...25,973,352
Ensembl chr17:25,967,587...25,973,352
|
|
| G
|
Msmo1
|
methylsterol monoxygenase 1
|
increases expression multiple interactions
|
ISO EXP
|
lead acetate results in increased expression of MSMO1 mRNA [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of MSMO1 mRNA; [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of MSMO1 protein
|
CTD |
PMID:38157908 PMID:38568856 |
|
NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826
|
|
| G
|
Msx2
|
msh homeobox 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MSX2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr13:53,620,917...53,626,816
Ensembl chr13:53,620,920...53,627,110
|
|
| G
|
mt-Atp8
|
ATP synthase 8, mitochondrial
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ATP8 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr MT:7,766...7,969
Ensembl chr MT:7,766...7,969
|
|
| G
|
mt-Co1
|
cytochrome c oxidase I, mitochondrial
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of COX1 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
|
|
| G
|
Mt1
|
metallothionein 1
|
increases expression multiple interactions affects expression decreases response to substance
|
EXP ISO
|
lead acetate results in increased expression of MT1 mRNA [lead acetate co-treated with Cadmium Chloride] results in increased expression of MT1A mRNA; lead acetate promotes the reaction [Cadmium Chloride results in increased expression of MT1A mRNA]; Melatonin promotes the reaction [lead acetate results in increased expression of MT1A mRNA] lead acetate results in increased expression of MT1 mRNA; lead acetate results in increased expression of MT1A mRNA lead acetate affects the expression of MT1 mRNA [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT1X mRNA lead acetate results in increased expression of MT1X mRNA MT1 results in decreased susceptibility to lead acetate
|
CTD |
PMID:12634122 PMID:19096765 PMID:20600549 PMID:21335049 PMID:22839698 PMID:24184865 PMID:25601058 PMID:26229098 PMID:30623991 PMID:33862172 More...
|
|
NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
|
|
| G
|
Mt2
|
metallothionein 2
|
decreases response to substance increases expression multiple interactions decreases expression
|
EXP ISO
|
MT2 results in decreased susceptibility to lead acetate lead acetate results in increased expression of MT2A mRNA [lead acetate co-treated with Cadmium Chloride] results in increased expression of MT2A mRNA; lead acetate promotes the reaction [Cadmium Chloride results in increased expression of MT2A mRNA]; Melatonin promotes the reaction [lead acetate results in increased expression of MT2A mRNA] lead acetate results in increased expression of MT2 mRNA lead acetate results in decreased expression of MT2A mRNA [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of MT2 mRNA
|
CTD |
PMID:19096765 PMID:20600549 PMID:21335049 PMID:22641619 PMID:22839698 PMID:24184865 PMID:25601058 PMID:30623991 PMID:33862172 PMID:38157908 PMID:38568856 More...
|
|
NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
|
|
| G
|
Mt3
|
metallothionein 3
|
multiple interactions decreases expression increases expression
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of MT3 mRNA coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of MT3 protein] lead acetate results in decreased expression of MT3 mRNA; lead acetate results in decreased expression of MT3 protein lead acetate results in increased expression of MT3 mRNA; lead acetate results in increased expression of MT3 protein
|
CTD |
PMID:12634122 PMID:29452138 PMID:33856607 |
|
NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774
|
|
| G
|
Mta1
|
metastasis associated 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of MTA1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:113,061,830...113,100,826
Ensembl chr12:113,061,898...113,100,826
|
|
| G
|
Mtf1
|
metal response element binding transcription factor 1
|
affects phosphorylation
|
ISO
|
lead acetate affects the phosphorylation of MTF1 protein
|
CTD |
PMID:24962574 |
|
NCBI chr 4:124,696,342...124,743,593
Ensembl chr 4:124,695,897...124,743,593
|
|
| G
|
Mtfr1l
|
mitochondrial fission regulator 1-like
|
increases expression
|
EXP
|
lead acetate results in increased expression of MTFR1L mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:134,252,866...134,262,698
Ensembl chr 4:134,252,861...134,262,698
|
|
| G
|
Mthfd2
|
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
|
increases expression
|
ISO
|
lead acetate results in increased expression of MTHFD2 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 6:83,282,686...83,302,926
Ensembl chr 6:83,282,673...83,302,890
|
|
| G
|
Mtmr10
|
myotubularin related protein 10
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MTMR10 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:63,937,443...63,990,556
Ensembl chr 7:63,937,401...63,990,554
|
|
| G
|
Mtor
|
mechanistic target of rapamycin kinase
|
decreases phosphorylation multiple interactions increases phosphorylation decreases expression
|
ISO
|
lead acetate results in decreased phosphorylation of MTOR protein [lead acetate results in increased abundance of Lead] which results in decreased expression of MTOR mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of MTOR protein; naringenin inhibits the reaction [lead acetate results in decreased expression of MTOR protein] lead acetate results in increased phosphorylation of MTOR protein SRT1720 inhibits the reaction [lead acetate results in increased phosphorylation of MTOR protein] lead acetate results in decreased expression of MTOR mRNA; lead acetate results in decreased expression of MTOR protein
|
CTD |
PMID:22811615 PMID:30980912 PMID:32879255 PMID:34842334 PMID:36652739 PMID:36807407 More...
|
|
NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
|
|
| G
|
Mtus1
|
mitochondrial tumor suppressor 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MTUS1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:41,443,949...41,587,318
Ensembl chr 8:41,443,951...41,586,763
|
|
| G
|
Mtx1
|
metaxin 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of MTX1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:89,116,388...89,121,214
Ensembl chr 3:89,116,388...89,134,395
|
|
| G
|
Muc1
|
mucin 1, transmembrane
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MUC1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688
|
|
| G
|
Muc5ac
|
mucin 5, subtypes A and C, tracheobronchial/gastric
|
increases expression
|
EXP
|
lead acetate results in increased expression of MUC5AC mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968
|
|
| G
|
Mug1
|
murinoglobulin 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MUG1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:121,815,455...121,866,016
Ensembl chr 6:121,815,500...121,866,016
|
|
| G
|
Mup4
|
major urinary protein 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of MUP4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 4:59,956,804...59,960,667
Ensembl chr 4:59,956,804...59,960,710
|
|
| G
|
Mustn1
|
musculoskeletal, embryonic nuclear protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of MUSTN1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:30,601,214...30,603,567
Ensembl chr14:30,601,157...30,603,567
|
|
| G
|
Mutyh
|
mutY DNA glycosylase
|
increases expression
|
EXP
|
lead acetate results in increased expression of MUTYH mRNA
|
CTD |
PMID:21335049 |
|
NCBI chr 4:116,664,846...116,676,641
Ensembl chr 4:116,664,920...116,676,637
|
|
| G
|
Mvd
|
mevalonate (diphospho) decarboxylase
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MVD mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 8:123,160,335...123,170,161
Ensembl chr 8:123,160,340...123,170,161
|
|
| G
|
Mvk
|
mevalonate kinase
|
multiple interactions
|
EXP
|
[[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of MVK mRNA; [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of MVK protein
|
CTD |
PMID:38157908 |
|
NCBI chr 5:114,582,324...114,598,652
Ensembl chr 5:114,582,330...114,598,652
|
|
| G
|
Mx2
|
MX dynamin-like GTPase 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MX2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr16:97,337,281...97,362,101
Ensembl chr16:97,336,508...97,362,100
|
|
| G
|
Mxd4
|
Max dimerization protein 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MXD4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:34,331,231...34,345,076
Ensembl chr 5:34,331,227...34,345,064
|
|
| G
|
Myadm
|
myeloid-associated differentiation marker
|
increases expression
|
ISO
|
lead acetate results in increased expression of MYADM mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:3,337,563...3,347,871
Ensembl chr 7:3,337,605...3,348,958
|
|
| G
|
Mybl1
|
myeloblastosis oncogene-like 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MYBL1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 1:9,737,632...9,770,664
Ensembl chr 1:9,737,640...9,770,434
|
|
| G
|
Mybpc1
|
myosin binding protein C, slow-type
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of MYBPC1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:88,354,141...88,441,051
Ensembl chr10:88,354,141...88,441,014
|
|
| G
|
Mybph
|
myosin binding protein H
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MYBPH mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 1:134,121,159...134,128,975
Ensembl chr 1:134,121,186...134,128,970
|
|
| G
|
Mycn
|
v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MYCN mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr12:12,986,094...12,991,837
Ensembl chr12:12,986,094...12,991,915
|
|
| G
|
Myd88
|
myeloid differentiation primary response gene 88
|
multiple interactions increases expression
|
EXP
|
3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in increased expression of MYD88 protein]
|
CTD |
PMID:37385299 |
|
NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
|
|
| G
|
Myh4
|
myosin, heavy polypeptide 4, skeletal muscle
|
decreases expression multiple interactions
|
EXP
|
lead acetate results in decreased expression of MYH4 mRNA; lead acetate results in decreased expression of MYH4 protein HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYH4 mRNA]; HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYH4 protein]
|
CTD |
PMID:37797690 |
|
NCBI chr11:67,128,638...67,151,273
Ensembl chr11:67,128,855...67,151,272
|
|
| G
|
Myh6
|
myosin, heavy polypeptide 6, cardiac muscle, alpha
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MYH6 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384
|
|
| G
|
Myl3
|
myosin, light polypeptide 3
|
affects expression
|
EXP
|
lead acetate affects the expression of MYL3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:110,592,746...110,598,870
Ensembl chr 9:110,570,929...110,598,866
|
|
| G
|
Myl9
|
myosin, light polypeptide 9, regulatory
|
increases expression
|
ISO
|
lead acetate results in increased expression of MYL9 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:156,617,373...156,623,578
Ensembl chr 2:156,617,340...156,623,578
|
|
| G
|
Myo5a
|
myosin VA
|
increases expression
|
ISO
|
lead acetate results in increased expression of MYO5A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:74,975,183...75,130,970
Ensembl chr 9:74,978,297...75,130,970
|
|
| G
|
Myo6
|
myosin VI
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MYO6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:80,072,262...80,219,011
Ensembl chr 9:80,072,313...80,219,011
|
|
| G
|
Myod1
|
myogenic differentiation 1
|
multiple interactions decreases expression
|
EXP
|
HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYOD1 mRNA]; HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYOD1 protein] lead acetate results in decreased expression of MYOD1 mRNA; lead acetate results in decreased expression of MYOD1 protein
|
CTD |
PMID:37797690 |
|
NCBI chr 7:46,025,898...46,028,516
Ensembl chr 7:46,025,898...46,028,523
|
|
| G
|
Myog
|
myogenin
|
decreases expression multiple interactions increases expression
|
EXP
|
lead acetate results in decreased expression of MYOG mRNA; lead acetate results in decreased expression of MYOG protein HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYOG mRNA]; HDAC2 protein promotes the reaction [lead acetate results in decreased expression of MYOG protein] lead acetate results in increased expression of MYOG mRNA
|
CTD |
PMID:22613225 PMID:37797690 |
|
NCBI chr 1:134,217,742...134,220,286
Ensembl chr 1:134,217,727...134,220,286
|
|
| G
|
Myoz1
|
myozenin 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of MYOZ1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr14:20,699,170...20,706,608
Ensembl chr14:20,699,175...20,706,608
|
|
| G
|
Myoz3
|
myozenin 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of MYOZ3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr18:60,706,789...60,724,931
Ensembl chr18:60,706,822...60,724,860
|
|
| G
|
N4bp2l2
|
NEDD4 binding protein 2-like 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of N4BP2L2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:150,515,310...150,589,213
Ensembl chr 5:150,531,472...150,589,648
|
|
| G
|
Naa20
|
N(alpha)-acetyltransferase 20, NatB catalytic subunit
|
increases expression
|
EXP
|
lead acetate results in increased expression of NAA20 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:145,743,454...145,758,345
Ensembl chr 2:145,744,019...145,758,345
|
|
| G
|
Naaa
|
N-acylethanolamine acid amidase
|
increases expression
|
EXP
|
lead acetate results in increased expression of NAAA mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:92,405,519...92,426,040
Ensembl chr 5:92,405,518...92,426,029
|
|
| G
|
Nacc1
|
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
|
increases expression
|
ISO
|
lead acetate results in increased expression of NACC1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:85,397,106...85,414,528
Ensembl chr 8:85,397,108...85,414,531
|
|
| G
|
Naga
|
N-acetyl galactosaminidase, alpha
|
increases expression
|
EXP
|
lead acetate results in increased expression of NAGA mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr15:82,213,746...82,222,983
Ensembl chr15:82,213,733...82,223,126
|
|
| G
|
Naip5
|
NLR family, apoptosis inhibitory protein 5
|
decreases expression increases expression
|
EXP
|
lead acetate results in decreased expression of NAIP5 mRNA lead acetate results in increased expression of NAIP5 mRNA
|
CTD |
PMID:21829687 PMID:22609695 |
|
NCBI chr13:100,348,243...100,387,437
Ensembl chr13:100,348,247...100,382,831
|
|
| G
|
Nanog
|
Nanog homeobox
|
decreases expression increases expression
|
EXP
|
lead acetate results in decreased expression of NANOG mRNA lead acetate results in increased expression of NANOG mRNA
|
CTD |
PMID:25270620 PMID:31715224 |
|
NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592
|
|
| G
|
Naprt
|
nicotinate phosphoribosyltransferase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of NAPRT mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:75,762,812...75,766,330
Ensembl chr15:75,762,805...75,766,330
|
|
| G
|
Narf
|
nuclear prelamin A recognition factor
|
increases expression
|
EXP
|
lead acetate results in increased expression of NARF mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:121,128,062...121,146,682
Ensembl chr11:121,128,079...121,146,682
|
|
| G
|
Nars1
|
asparaginyl-tRNA synthetase 1
|
increases expression
|
ISO EXP
|
lead acetate results in increased expression of NARS1 mRNA
|
CTD |
PMID:11578147 PMID:25270620 |
|
NCBI chr18:64,632,726...64,649,586
Ensembl chr18:64,632,718...64,649,723
|
|
| G
|
Nat1
|
N-acetyl transferase 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of NAT1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:67,943,620...67,945,183
Ensembl chr 8:67,933,573...67,944,756
|
|
| G
|
Nav3
|
neuron navigator 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of NAV3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:109,517,121...110,292,148
Ensembl chr10:109,517,120...110,292,065
|
|
| G
|
Nbl1
|
NBL1, DAN family BMP antagonist
|
increases expression
|
ISO
|
lead acetate results in increased expression of NBL1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:138,809,602...138,820,437
Ensembl chr 4:138,809,595...138,820,304
|
|
| G
|
Ncam2
|
neural cell adhesion molecule 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NCAM2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:80,997,501...81,425,549
Ensembl chr16:80,997,585...81,423,716
|
|
| G
|
Ncf1
|
neutrophil cytosolic factor 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of NCF1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479
|
|
| G
|
Ncoa2
|
nuclear receptor coactivator 2
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of NCOA2 mRNA lead acetate promotes the reaction [VDR protein binds to NCOA2 protein]
|
CTD |
PMID:21229763 PMID:22641619 |
|
NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307
|
|
| G
|
Ncoa4
|
nuclear receptor coactivator 4
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of NCOA4 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of NCOA4 protein; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NCOA4 mRNA]; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NCOA4 protein]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NCOA4 mRNA]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NCOA4 protein]
|
CTD |
PMID:39276841 |
|
NCBI chr14:31,881,884...31,901,210
Ensembl chr14:31,881,822...31,901,812
|
|
| G
|
Ncoa7
|
nuclear receptor coactivator 7
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of NCOA7 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:30,521,578...30,683,401
Ensembl chr10:30,504,995...30,679,322
|
|
| G
|
Ncor2
|
nuclear receptor co-repressor 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of NCOR2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:125,094,217...125,256,302
Ensembl chr 5:125,094,217...125,256,283
|
|
| G
|
Ncs1
|
neuronal calcium sensor 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of NCS1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:31,135,766...31,186,001
Ensembl chr 2:31,135,835...31,186,001
|
|
| G
|
Ncstn
|
nicastrin
|
increases expression
|
EXP
|
lead acetate results in increased expression of NCSTN mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:171,893,580...171,910,356
Ensembl chr 1:171,893,580...171,910,362
|
|
| G
|
Ndrg1
|
N-myc downstream regulated gene 1
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of NDRG1 mRNA lead acetate results in decreased expression of NDRG1 mRNA
|
CTD |
PMID:20542052 PMID:38568856 |
|
NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489
|
|
| G
|
Ndufa7
|
NADH:ubiquinone oxidoreductase subunit A7
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NDUFA7 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:34,043,546...34,057,290
Ensembl chr17:34,043,546...34,057,291
|
|
| G
|
Ndufa9
|
NADH:ubiquinone oxidoreductase subunit A9
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NDUFA9 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:126,798,826...126,826,107
Ensembl chr 6:126,798,684...126,826,099
|
|
| G
|
Ndufab1
|
NADH:ubiquinone oxidoreductase subunit AB1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NDUFAB1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:121,686,038...121,701,071
Ensembl chr 7:121,684,626...121,701,109
|
|
| G
|
Ndufb8
|
NADH:ubiquinone oxidoreductase subunit B8
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of NDUFB8 protein; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NDUFB8 protein]
|
CTD |
PMID:36096218 |
|
NCBI chr19:44,537,010...44,543,881
Ensembl chr19:44,537,011...44,543,879
|
|
| G
|
Ndufc1
|
NADH:ubiquinone oxidoreductase subunit C1
|
increases expression
|
EXP
|
lead acetate results in increased expression of NDUFC1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:51,312,876...51,323,167
Ensembl chr 3:51,312,098...51,316,409
|
|
| G
|
Ndufs1
|
NADH:ubiquinone oxidoreductase core subunit S1
|
increases expression
|
EXP
|
lead acetate results in increased expression of NDUFS1 protein
|
CTD |
PMID:20797405 |
|
NCBI chr 1:63,182,751...63,215,981
Ensembl chr 1:63,182,755...63,215,992
|
|
| G
|
Nefh
|
neurofilament, heavy polypeptide
|
increases expression
|
EXP
|
lead acetate results in increased expression of NEFH protein
|
CTD |
PMID:20797405 |
|
NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064
|
|
| G
|
Nefl
|
neurofilament, light polypeptide
|
increases expression
|
EXP
|
lead acetate results in increased expression of NEFL protein
|
CTD |
PMID:20797405 |
|
NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
|
|
| G
|
Nefm
|
neurofilament, medium polypeptide
|
affects expression multiple interactions
|
EXP ISO
|
lead acetate affects the expression of NEFM protein [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of NEFM protein
|
CTD |
PMID:20797405 PMID:23680456 |
|
NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295
|
|
| G
|
Nelfa
|
negative elongation factor complex member A, Whsc2
|
increases expression
|
EXP
|
lead acetate results in increased expression of NELFA mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:34,055,263...34,093,615
Ensembl chr 5:34,055,260...34,093,757
|
|
| G
|
Nemf
|
nuclear export mediator factor
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NEMF mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr12:69,358,315...69,403,975
Ensembl chr12:69,357,296...69,403,939
|
|
| G
|
Nes
|
nestin
|
increases expression multiple interactions decreases expression
|
EXP ISO
|
lead acetate results in increased expression of NES mRNA F2RL2 protein inhibits the reaction [lead acetate results in increased expression of NES mRNA] lead acetate results in decreased expression of NES protein
|
CTD |
PMID:24260418 PMID:25496477 PMID:37939567 PMID:38072110 |
|
NCBI chr 3:87,878,400...87,887,758
Ensembl chr 3:87,878,385...87,887,758
|
|
| G
|
Net1
|
neuroepithelial cell transforming gene 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of NET1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr13:3,932,018...3,968,220
Ensembl chr13:3,932,018...3,968,220
|
|
| G
|
Neurl4
|
neuralized E3 ubiquitin protein ligase 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of NEURL4 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:69,792,545...69,804,648
Ensembl chr11:69,791,898...69,804,646
|
|
| G
|
Neurod1
|
neurogenic differentiation 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NEUROD1 mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 2:79,282,981...79,286,980
Ensembl chr 2:79,282,865...79,287,095
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| G
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Neurod4
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neurogenic differentiation 4
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decreases expression
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ISO
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lead acetate results in decreased expression of NEUROD4 mRNA
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CTD |
PMID:22641619 |
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NCBI chr10:130,104,021...130,116,123
Ensembl chr10:130,104,021...130,116,109
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| G
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Neurog1
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neurogenin 1
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increases expression
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EXP
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lead acetate results in increased expression of NEUROG1 mRNA
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CTD |
PMID:24260418 |
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NCBI chr13:56,398,291...56,399,993
Ensembl chr13:56,398,291...56,399,976
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| G
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Nf1
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neurofibromin 1
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decreases expression
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EXP
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lead acetate results in decreased expression of NF1 mRNA
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CTD |
PMID:33932463 |
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NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438
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| G
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Nfasc
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neurofascin
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increases expression
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EXP
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lead acetate results in increased expression of NFASC mRNA
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CTD |
PMID:20542052 |
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NCBI chr 1:132,492,428...132,669,567
Ensembl chr 1:132,492,428...132,669,535
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| G
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Nfe2l2
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nuclear factor, erythroid derived 2, like 2
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affects localization increases expression multiple interactions increases activity decreases expression
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ISO EXP
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lead acetate affects the localization of NFE2L2 protein lead acetate results in increased expression of NFE2L2 mRNA [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of NFE2L2 protein; [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of NFE2L2 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of NFE2L2 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA; [Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]; Fatty Acids, Omega-3 inhibits the reaction [lead acetate results in decreased expression of and affects the localization of NFE2L2 protein]; lead acetate results in decreased expression of and affects the localization of NFE2L2 protein lead acetate results in increased activity of NFE2L2 protein [[lead acetate results in increased abundance of Lead] which co-treated with Rutin] affects the localization of NFE2L2 protein; [lead acetate results in increased abundance of Lead] inhibits the reaction [Ascorbic Acid results in increased expression of NFE2L2 protein]; [lead acetate results in increased abundance of Lead] inhibits the reaction [Rosmarinic Acid results in increased expression of NFE2L2 protein]; [lead acetate results in increased abundance of Lead] which affects the localization of NFE2L2 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA; Ascorbic Acid promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]; lead acetate results in increased activity of and affects the localization of NFE2L2 protein; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased activity of and affects the localization of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GSTA1 mRNA]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [[[lead acetate results in increased abundance of Lead] which co-treated with Rutin] results in increased expression of IL10 mRNA]; NFE2L2 protein affects the reaction [[[lead acetate results in increased abundance of Lead] which co-treated with Rutin] results in increased expression of IL10 protein]; NFE2L2 protein affects the reaction [lead acetate results in increased expression of SPP1 mRNA]; NFE2L2 protein affects the reaction [Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of IL1B mRNA]]; NFE2L2 protein affects the reaction [Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of TNF mRNA]]; NFE2L2 protein affects the reaction [Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of TNF protein]]; NFE2L2 protein inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]; NFE2L2 protein inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; NFE2L2 protein inhibits the reaction [lead acetate results in increased expression of BAX protein]; Rosmarinic Acid affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA] lead acetate results in decreased expression of NFE2L2 mRNA; lead acetate results in decreased expression of NFE2L2 protein 2-tert-butylhydroquinone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 protein]; 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]; [lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 protein; Cholecalciferol promotes the reaction [lead acetate results in increased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate affects the localization of NFE2L2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 protein]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 protein]; ferrostatin-1 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]; Genistein inhibits the reaction [lead acetate results in decreased expression of NFE2L2 protein]; lead acetate promotes the reaction [Zinc Oxide results in increased expression of and affects the localization of NFE2L2 protein]; lead acetate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NQO1 protein]; NFE2L2 protein results in decreased susceptibility to [lead acetate results in increased abundance of Lead]; sinapinic acid inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of and affects the localization of NFE2L2 protein]
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CTD |
PMID:23274417 PMID:26498409 PMID:26797587 PMID:27562236 PMID:30114225 PMID:30476502 PMID:30523571 PMID:31610155 PMID:32116774 PMID:32208856 PMID:33862172 PMID:34051273 PMID:34553816 PMID:35527006 PMID:37471654 PMID:38180308 PMID:39032614 PMID:39276841 More...
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NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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| G
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Nfia
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nuclear factor I/A
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increases expression
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EXP
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lead acetate results in increased expression of NFIA mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:97,469,534...98,007,113
Ensembl chr 4:97,660,971...98,007,111
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| G
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Nfil3
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nuclear factor, interleukin 3, regulated
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decreases expression
|
ISO
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lead acetate results in decreased expression of NFIL3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:53,121,245...53,136,914
Ensembl chr13:53,121,245...53,135,109
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| G
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Nfix
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nuclear factor I/X
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multiple interactions
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ISO
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[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NFIX mRNA
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CTD |
PMID:12634122 |
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NCBI chr 8:85,431,341...85,527,086
Ensembl chr 8:85,426,505...85,526,973
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| G
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Nfkb1
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nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
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multiple interactions increases expression decreases expression
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ISO
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sinapinic acid inhibits the reaction [lead acetate results in increased expression of NFKB1 mRNA] lead acetate results in decreased expression of NFKB1 protein
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CTD |
PMID:16547843 PMID:37471654 |
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NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
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| G
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Nfkb2
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nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
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increases expression multiple interactions decreases expression
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ISO EXP
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lead acetate results in increased expression of NFKB2 mRNA Cholecalciferol inhibits the reaction [lead acetate results in increased expression of NFKB2 mRNA] lead acetate results in decreased expression of NFKB2 mRNA
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CTD |
PMID:24260418 PMID:34051273 |
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NCBI chr19:46,285,478...46,300,839
Ensembl chr19:46,292,759...46,300,824
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| G
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Nfkbia
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nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
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decreases expression
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EXP
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lead acetate results in decreased expression of NFKBIA mRNA
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CTD |
PMID:21829687 |
|
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
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| G
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Nfya
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nuclear transcription factor-Y alpha
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increases expression
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EXP
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lead acetate results in increased expression of NFYA mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:48,693,917...48,716,782
Ensembl chr17:48,693,913...48,716,934
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| G
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Ngb
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neuroglobin
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multiple interactions
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ISO
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[lead acetate results in increased abundance of Lead] which results in increased expression of NGB mRNA
|
CTD |
PMID:36642386 |
|
NCBI chr12:87,144,305...87,149,313
Ensembl chr12:87,144,305...87,149,313
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|
| G
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Ngf
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nerve growth factor
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multiple interactions affects expression increases activity
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ISO EXP
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2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased activity of NGF protein] lead acetate affects the expression of NGF mRNA lead acetate results in decreased expression of and affects the localization of NGF protein
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CTD |
PMID:11233754 PMID:24260418 PMID:28427492 |
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NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
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| G
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Niban2
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niban apoptosis regulator 2
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increases expression
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ISO
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lead acetate results in increased expression of NIBAN2 mRNA
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CTD |
PMID:38568856 |
|
NCBI chr 2:32,766,146...32,815,265
Ensembl chr 2:32,766,126...32,815,266
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| G
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Nid1
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nidogen 1
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multiple interactions
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ISO
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[sodium arsenite co-treated with lead acetate] results in increased expression of NID1 protein
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CTD |
PMID:38072110 |
|
NCBI chr13:13,612,252...13,686,849
Ensembl chr13:13,612,136...13,686,854
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| G
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Nif3l1
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Ngg1 interacting factor 3-like 1 (S. pombe)
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increases expression
|
EXP
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lead acetate results in increased expression of NIF3L1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:58,484,310...58,501,435
Ensembl chr 1:58,484,310...58,520,975
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| G
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Nin
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ninein
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decreases expression
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EXP
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lead acetate results in decreased expression of NIN mRNA
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CTD |
PMID:21829687 |
|
NCBI chr12:70,058,209...70,160,575
Ensembl chr12:70,058,209...70,160,491
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| G
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Nkx2-2
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NK2 homeobox 2
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decreases expression
|
EXP
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lead acetate results in decreased expression of NKX2-2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:146,967,909...147,037,270
Ensembl chr 2:147,019,466...147,036,163
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| G
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Nkx6-2
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NK6 homeobox 2
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increases expression
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ISO
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lead acetate results in increased expression of NKX6-2 mRNA
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CTD |
PMID:22641619 |
|
NCBI chr 7:139,159,292...139,162,726
Ensembl chr 7:139,159,292...139,162,713
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| G
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Nlgn1
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neuroligin 1
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multiple interactions
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ISO
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[lead acetate results in increased abundance of Lead] which results in decreased expression of NLGN1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of NLGN1 protein
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CTD |
PMID:29476096 |
|
NCBI chr 3:25,475,972...26,387,504
Ensembl chr 3:25,480,379...26,386,609
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| G
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Nlrp3
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NLR family, pyrin domain containing 3
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multiple interactions increases expression
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EXP ISO
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1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NLRP3 protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of NLRP3 protein; NLRP3 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL1B protein]; NLRP3 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of IL6 protein]; NLRP3 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of TNF protein]; NLRP3 gene mutant form results in decreased susceptibility to [lead acetate results in increased abundance of Lead] lead acetate results in increased expression of NLRP3 mRNA sinapinic acid inhibits the reaction [lead acetate results in increased expression of NLRP3 mRNA]
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CTD |
PMID:36308466 PMID:37471654 |
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NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
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| G
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Nlrp5
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NLR family, pyrin domain containing 5
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increases expression
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EXP
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lead acetate results in increased expression of NLRP5 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:23,085,314...23,141,348
Ensembl chr 7:23,085,314...23,141,347
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| G
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Nmbr
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neuromedin B receptor
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increases expression affects expression
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EXP ISO
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lead acetate results in increased expression of NMBR mRNA lead acetate affects the expression of NMBR mRNA
|
CTD |
PMID:20542052 PMID:22641619 |
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NCBI chr10:14,634,894...14,647,202
Ensembl chr10:14,581,335...14,646,594
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|
| G
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Nme4
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NME/NM23 nucleoside diphosphate kinase 4
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multiple interactions
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ISO
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[sodium arsenite co-treated with lead acetate] results in increased expression of NME4 protein
|
CTD |
PMID:38072110 |
|
NCBI chr17:26,310,708...26,314,650
Ensembl chr17:26,310,708...26,314,576
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|
| G
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Nmur2
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neuromedin U receptor 2
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increases expression
|
ISO
|
lead acetate results in increased expression of NMUR2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:55,915,816...55,931,813
Ensembl chr11:55,915,813...55,931,836
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| G
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Nod1
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nucleotide-binding oligomerization domain containing 1
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decreases expression
|
EXP
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lead acetate results in decreased expression of NOD1 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 6:54,900,927...54,949,655
Ensembl chr 6:54,900,934...54,949,597
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| G
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Nod2
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nucleotide-binding oligomerization domain containing 2
|
increases expression
|
EXP
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lead acetate results in increased expression of NOD2 mRNA
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CTD |
PMID:20542052 |
|
NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102
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| G
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Nolc1
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nucleolar and coiled-body phosphoprotein 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of NOLC1 promoter
|
CTD |
PMID:33445541 |
|
NCBI chr19:46,064,286...46,073,982
Ensembl chr19:46,064,302...46,073,969
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|
| G
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Nop10
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NOP10 ribonucleoprotein
|
increases expression
|
ISO
|
lead acetate results in increased expression of NOP10 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:112,092,271...112,093,243
Ensembl chr 2:112,092,271...112,093,614
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| G
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Nos1
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nitric oxide synthase 1, neuronal
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multiple interactions increases expression decreases expression
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ISO EXP
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tempol inhibits the reaction [lead acetate results in increased expression of NOS1 protein] [lead acetate results in increased abundance of Lead] which results in decreased expression of NOS1 protein; puerarin inhibits the reaction [lead acetate results in decreased expression of NOS1 protein]; Quercetin inhibits the reaction [lead acetate results in decreased expression of NOS1 protein]
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CTD |
PMID:11454931 PMID:21195594 PMID:23501611 PMID:23855546 PMID:26660114 |
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NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
|
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| G
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Nos2
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nitric oxide synthase 2, inducible
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increases expression multiple interactions
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EXP ISO
|
lead acetate results in increased expression of NOS2 mRNA lead acetate results in increased expression of NOS2 mRNA; lead acetate results in increased expression of NOS2 protein 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in increased expression of NOS2 mRNA]; [lead acetate results in increased abundance of Lead] which results in increased expression of NOS2 mRNA; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [lead acetate results in increased expression of NOS2 protein]; sodium bisulfide inhibits the reaction [lead acetate results in increased expression of NOS2 protein]; sodium boranocarbonate inhibits the reaction [lead acetate results in increased expression of NOS2 protein]; tempol inhibits the reaction [lead acetate results in increased expression of NOS2 protein] [lead acetate results in increased abundance of Lead] which results in increased expression of NOS2 protein; MitoTEMPO inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NOS2 protein]
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CTD |
PMID:11454931 PMID:22609695 PMID:22952811 PMID:30980911 PMID:32116774 PMID:32208856 PMID:35307918 PMID:36308466 More...
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|
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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|
| G
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Nos3
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nitric oxide synthase 3, endothelial cell
|
increases expression decreases expression multiple interactions
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ISO EXP
|
lead acetate results in increased expression of NOS3 protein lead acetate results in decreased expression of NOS3 protein puerarin inhibits the reaction [lead acetate results in decreased expression of NOS3 protein]; Quercetin inhibits the reaction [lead acetate results in decreased expression of NOS3 protein] Ascorbic Acid inhibits the reaction [lead acetate results in increased expression of NOS3 protein]; sodium bisulfide inhibits the reaction [lead acetate results in decreased expression of NOS3 protein]; sodium boranocarbonate inhibits the reaction [lead acetate results in decreased expression of NOS3 protein]; tempol inhibits the reaction [lead acetate results in increased expression of NOS3 protein] tempol inhibits the reaction [lead acetate results in increased expression of NOS3 protein]; U 74389F inhibits the reaction [lead acetate results in increased expression of NOS3 protein]
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CTD |
PMID:11230275 PMID:11454931 PMID:11729227 PMID:23501611 PMID:23855546 PMID:30980911 More...
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NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
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|
| G
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Notch2
|
notch 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of NOTCH2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 3:97,920,854...98,057,683
Ensembl chr 3:97,920,843...98,057,677
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|
| G
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Notch4
|
notch 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of NOTCH4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr17:34,783,257...34,807,517
Ensembl chr17:34,783,242...34,807,477
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|
| G
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Nox1
|
NADPH oxidase 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of NOX1 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr X:132,987,170...133,038,455
Ensembl chr X:132,987,170...133,122,705
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|
| G
|
Nox4
|
NADPH oxidase 4
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NOX4 mRNA
|
CTD |
PMID:29746905 |
|
NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918
|
|
| G
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Npas4
|
neuronal PAS domain protein 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of NPAS4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr19:5,034,381...5,053,467
Ensembl chr19:5,034,383...5,040,344
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|
| G
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Npepl1
|
aminopeptidase-like 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of NPEPL1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:173,951,904...173,964,495
Ensembl chr 2:173,952,142...173,964,863
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|
| G
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Npffr2
|
neuropeptide FF receptor 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NPFFR2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:89,674,805...89,731,473
Ensembl chr 5:89,675,288...89,731,599
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|
| G
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Npm1
|
nucleophosmin 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of NPM1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:33,102,498...33,114,143
Ensembl chr11:33,102,287...33,113,206
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|
| G
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Npnt
|
nephronectin
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NPNT mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 3:132,587,506...132,656,052
Ensembl chr 3:132,587,506...132,656,052
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|
| G
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Npr1
|
natriuretic peptide receptor 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of NPR1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 3:90,357,898...90,373,235
Ensembl chr 3:90,357,898...90,373,173
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|
| G
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Npr3
|
natriuretic peptide receptor 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of NPR3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr15:11,839,982...11,907,287
Ensembl chr15:11,839,982...11,907,373
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| G
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Nprl2
|
NPR2 like, GATOR1 complex subunit
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of NPRL2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:107,419,405...107,422,905
Ensembl chr 9:107,419,425...107,422,905
|
|
| G
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Npsr1
|
neuropeptide S receptor 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of NPSR1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:24,009,212...24,229,151
Ensembl chr 9:24,009,292...24,227,694
|
|
| G
|
Nptx1
|
neuronal pentraxin 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of NPTX1 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr11:119,429,545...119,438,646
Ensembl chr11:119,429,545...119,438,579
|
|
| G
|
Npy1r
|
neuropeptide Y receptor Y1
|
increases expression
|
ISO
|
lead acetate results in increased expression of NPY1R mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444
|
|
| G
|
Nqo1
|
NAD(P)H dehydrogenase, quinone 1
|
increases expression multiple interactions decreases expression
|
EXP ISO
|
lead acetate results in increased expression of NQO1 mRNA 2-tert-butylhydroquinone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NQO1 protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of NQO1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NQO1 protein]; sinapinic acid inhibits the reaction [lead acetate results in decreased expression of NQO1 mRNA] [lead acetate results in increased abundance of Lead] which results in decreased expression of NQO1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of NQO1 mRNA; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of NQO1 mRNA]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NQO1 mRNA]; Rutin promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NQO1 mRNA]
|
CTD |
PMID:25270620 PMID:26498409 PMID:27562236 PMID:30476502 PMID:31610155 PMID:33862172 PMID:37471654 PMID:37939567 PMID:38568856 PMID:39032614 PMID:39276841 More...
|
|
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
|
|
| G
|
Nqo2
|
N-ribosyldihydronicotinamide quinone reductase 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of NQO2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426
|
|
| G
|
Nr1h3
|
nuclear receptor subfamily 1, group H, member 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of NR1H3 mRNA; lead acetate results in increased expression of NR1H3 protein
|
CTD |
PMID:29908845 |
|
NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179
|
|
| G
|
Nr2e3
|
nuclear receptor subfamily 2, group E, member 3
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of NR2E3 mRNA
|
CTD |
PMID:28050121 |
|
NCBI chr 9:59,850,054...59,868,117
Ensembl chr 9:59,850,054...59,867,942
|
|
| G
|
Nr2f2
|
nuclear receptor subfamily 2, group F, member 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NR2F2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:70,001,694...70,016,494
Ensembl chr 7:70,001,692...70,016,483
|
|
| G
|
Nr2f6
|
nuclear receptor subfamily 2, group F, member 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NR2F6 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 8:71,826,762...71,834,593
Ensembl chr 8:71,826,767...71,834,604
|
|
| G
|
Nr3c1
|
nuclear receptor subfamily 3, group C, member 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which affects the expression of NR3C1 protein; [lead acetate results in increased abundance of Lead] which results in decreased methylation of NR3C1 exon
|
CTD |
PMID:29481626 |
|
NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
|
|
| G
|
Nr4a1
|
nuclear receptor subfamily 4, group A, member 1
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of NR4A1 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of NR4A1 protein
|
CTD |
PMID:22641619 PMID:39947421 |
|
NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676
|
|
| G
|
Nrcam
|
neuronal cell adhesion molecule
|
increases expression
|
ISO
|
lead acetate results in increased expression of NRCAM mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:44,375,568...44,651,977
Ensembl chr12:44,375,668...44,648,747
|
|
| G
|
Nrep
|
neuronal regeneration related protein
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of NREP mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082
|
|
| G
|
Nrgn
|
neurogranin
|
increases expression
|
ISO
|
lead acetate results in increased expression of NRGN mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:37,455,789...37,464,041
Ensembl chr 9:37,455,788...37,464,200
|
|
| G
|
Nrip1
|
nuclear receptor interacting protein 1
|
affects expression
|
EXP
|
lead acetate affects the expression of NRIP1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715
|
|
| G
|
Nrk
|
Nik related kinase
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of NRK intron
|
CTD |
PMID:33445541 |
|
NCBI chr X:137,814,980...137,911,281
Ensembl chr X:137,815,179...137,911,281
|
|
| G
|
Nrl
|
neural retina leucine zipper gene
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of NRL mRNA
|
CTD |
PMID:28050121 |
|
NCBI chr14:55,756,973...55,762,438
Ensembl chr14:55,756,435...55,762,438
|
|
| G
|
Nsa2
|
NSA2 ribosome biogenesis homolog
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NSA2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr13:97,265,935...97,274,434
Ensembl chr13:97,265,932...97,274,445
|
|
| G
|
Nsdhl
|
NAD(P) dependent steroid dehydrogenase-like
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NSDHL mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr X:71,962,127...72,002,134
Ensembl chr X:71,962,163...72,002,120
|
|
| G
|
Nsg1
|
neuron specific gene family member 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of NSG1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 5:38,294,537...38,317,087
Ensembl chr 5:38,294,536...38,317,251
|
|
| G
|
Nsmce1
|
NSE1 homolog, SMC5-SMC6 complex component
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NSMCE1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:125,066,816...125,090,615
Ensembl chr 7:125,066,812...125,090,768
|
|
| G
|
Nsun2
|
NOL1/NOP2/Sun domain family member 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of NSUN2 protein
|
CTD |
PMID:38072110 |
|
NCBI chr13:69,760,135...69,783,899
Ensembl chr13:69,681,865...69,783,899
|
|
| G
|
Nsun3
|
NOL1/NOP2/Sun domain family member 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of NSUN3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr16:62,552,807...62,607,238
Ensembl chr16:62,552,807...62,607,181
|
|
| G
|
Nt5c1b
|
5'-nucleotidase, cytosolic IB
|
increases expression
|
EXP
|
lead acetate results in increased expression of NT5C1B mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr12:10,419,971...10,440,174
Ensembl chr12:10,419,973...10,440,175
|
|
| G
|
Nt5e
|
5' nucleotidase, ecto
|
increases expression
|
ISO
|
lead acetate results in increased expression of NT5E mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:88,209,662...88,254,142
Ensembl chr 9:88,209,250...88,254,145
|
|
| G
|
Ntf3
|
neurotrophin 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of NTF3 mRNA
|
CTD |
PMID:22160880 |
|
NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873
|
|
| G
|
Ntf5
|
neurotrophin 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of NTF4 mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 7:45,063,119...45,066,603
Ensembl chr 7:45,063,119...45,066,603
|
|
| G
|
Nthl1
|
nth (endonuclease III)-like 1 (E.coli)
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of NTHL1 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr17:24,851,656...24,857,812
Ensembl chr17:24,851,654...24,857,811
|
|
| G
|
Ntmt2
|
N-terminal Xaa-Pro-Lys N-methyltransferase 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of NTMT2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:163,529,415...163,552,801
Ensembl chr 1:163,529,825...163,552,801
|
|
| G
|
Ntng1
|
netrin G1
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of NTNG1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 3:109,687,366...110,057,291
Ensembl chr 3:109,687,356...110,051,327
|
|
| G
|
Ntrk2
|
neurotrophic tyrosine kinase, receptor, type 2
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of NTRK2 protein lead acetate results in increased expression of NTRK2 mRNA
|
CTD |
PMID:27492863 PMID:33862172 |
|
NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784
|
|
| G
|
Nuak2
|
NUAK family, SNF1-like kinase, 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of NUAK2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:132,243,827...132,261,233
Ensembl chr 1:132,243,864...132,261,226
|
|
| G
|
Nudcd3
|
NudC domain containing 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of NUDCD3 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:6,055,705...6,150,190
Ensembl chr11:6,055,691...6,150,415
|
|
| G
|
Nup210
|
nucleoporin 210
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of NUP210 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:90,990,049...91,095,920
Ensembl chr 6:90,990,050...91,093,811
|
|
| G
|
Nupr1
|
nuclear protein transcription regulator 1
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of NUPR1 mRNA
|
CTD |
PMID:22641619 PMID:25270620 |
|
NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033
|
|
| G
|
Nxpe4
|
neurexophilin and PC-esterase domain family, member 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of NXPE4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:48,073,302...48,311,325
Ensembl chr 9:48,073,321...48,311,325
|
|
| G
|
Oas1g
|
2'-5' oligoadenylate synthetase 1G
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of OAS1A mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:121,014,205...121,025,676
Ensembl chr 5:121,014,205...121,025,676
|
|
| G
|
Ocln
|
occludin
|
multiple interactions decreases expression
|
ISO
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of OCLN protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of OCLN protein]
|
CTD |
PMID:24200059 |
|
NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226
|
|
| G
|
Ogfr
|
opioid growth factor receptor
|
increases expression
|
ISO
|
lead acetate results in increased expression of OGFR mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:180,231,200...180,237,630
Ensembl chr 2:180,231,038...180,237,629
|
|
| G
|
Olfml3
|
olfactomedin-like 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of OLFML3 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 3:103,642,710...103,645,317
Ensembl chr 3:103,629,538...103,645,317
|
|
| G
|
Olig1
|
oligodendrocyte transcription factor 1
|
decreases expression multiple interactions
|
EXP ISO
|
lead acetate results in decreased expression of OLIG1 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of OLIG1 mRNA
|
CTD |
PMID:25270620 PMID:32458983 |
|
NCBI chr16:91,066,657...91,068,827
Ensembl chr16:91,066,660...91,068,821
|
|
| G
|
Olig2
|
oligodendrocyte transcription factor 2
|
multiple interactions increases expression
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of OLIG2 mRNA; F2RL2 protein promotes the reaction [lead acetate results in increased expression of OLIG2 mRNA]; PANX2 protein promotes the reaction [lead acetate results in increased expression of OLIG2 mRNA]; TRIM16L protein promotes the reaction [lead acetate results in increased expression of OLIG2 mRNA]
|
CTD |
PMID:32458983 PMID:37939567 |
|
NCBI chr16:91,016,745...91,025,567
Ensembl chr16:91,022,345...91,025,565
|
|
| G
|
Omd
|
osteomodulin
|
increases expression
|
ISO
|
lead acetate results in increased expression of OMD mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr13:49,735,938...49,746,088
Ensembl chr13:49,735,938...49,746,298
|
|
| G
|
Omt2b
|
oocyte maturation, beta
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OMT2B mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:78,235,312...78,236,902
Ensembl chr 9:78,234,871...78,236,902
|
|
| G
|
Onecut1
|
one cut domain, family member 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of ONECUT1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:74,769,203...74,796,930
Ensembl chr 9:74,769,203...74,799,063
|
|
| G
|
Oog1
|
oogenesin 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of OOG1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr12:87,649,435...87,655,615
Ensembl chr12:87,649,458...87,655,620
|
|
| G
|
Opn3
|
opsin 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of OPN3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:175,489,993...175,520,198
Ensembl chr 1:175,489,987...175,520,342
|
|
| G
|
Oprm1
|
opioid receptor, mu 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] promotes the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]
|
CTD |
PMID:33248188 |
|
NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198
|
|
| G
|
Or11i1
|
olfactory receptor family 11 subfamily I member 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR11I1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 3:106,728,923...106,729,873
Ensembl chr 3:106,727,801...106,733,603
|
|
| G
|
Or13g1
|
olfactory receptor family 13 subfamily G member 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR13G1 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:85,955,393...85,956,319
Ensembl chr 7:85,953,682...85,962,916
|
|
| G
|
Or14j5
|
olfactory receptor family 14 subfamily J member 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR14J5 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr17:38,161,485...38,162,444
Ensembl chr17:38,158,374...38,162,948
|
|
| G
|
Or14j6
|
olfactory receptor family 14 subfamily J member 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR14J6 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr17:38,214,439...38,215,410
Ensembl chr17:38,211,328...38,217,686
|
|
| G
|
Or1e1f
|
olfactory receptor family 1 subfamily E member 1F
|
increases expression
|
EXP
|
lead acetate results in increased expression of OR1E1F mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:73,855,436...73,856,383
Ensembl chr11:73,851,643...73,858,638
|
|
| G
|
Or2y13
|
olfactory receptor family 2 subfamily Y member 14
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR2Y13 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr11:49,414,552...49,415,487
Ensembl chr11:49,410,475...49,418,026
|
|
| G
|
Or4c102
|
olfactory receptor family 4 subfamily C member 102
|
increases expression
|
EXP
|
lead acetate results in increased expression of OR4C102 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:88,422,150...88,423,070
Ensembl chr 2:88,416,798...88,423,106
|
|
| G
|
Or4c118
|
olfactory receptor family 4 subfamily C member 118
|
increases expression
|
EXP
|
lead acetate results in increased expression of OR4C118 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:88,974,430...88,981,680
Ensembl chr 2:88,973,852...88,981,904
|
|
| G
|
Or4c120
|
olfactory receptor family 4 subfamily C member 120
|
increases expression
|
EXP
|
lead acetate results in increased expression of OR4C120 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:89,000,563...89,001,589
Ensembl chr 2:88,998,724...89,005,013
|
|
| G
|
Or4c15b
|
olfactory receptor family 4 subfamily C member 15B
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR4C15B mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:89,112,540...89,113,475
Ensembl chr 2:89,110,820...89,118,358
|
|
| G
|
Or4d10b
|
olfactory receptor family 4 subfamily D member 10B
|
increases expression
|
EXP
|
lead acetate results in increased expression of OR4D10B mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr19:12,036,173...12,037,114
Ensembl chr19:12,035,988...12,040,046
|
|
| G
|
Or4d2
|
olfactory receptor family 4 subfamily D member 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR4D2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr11:87,783,813...87,784,748
Ensembl chr11:87,783,444...87,788,213
|
|
| G
|
Or4k1
|
olfactory receptor family 4 subfamily K member 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR4K1 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr14:50,377,159...50,378,094
Ensembl chr14:50,371,215...50,380,137
|
|
| G
|
Or4k2
|
olfactory receptor family 4 subfamily K member 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR4K2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr14:50,423,719...50,424,675
Ensembl chr14:50,420,753...50,425,655
|
|
| G
|
Or4k37
|
olfactory receptor family 4 subfamily K member 37
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR4K37 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:111,158,766...111,159,683
Ensembl chr 2:111,156,865...111,163,197
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| G
|
Or4k42
|
olfactory receptor family 4 subfamily K member 42
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR4K42 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:111,319,563...111,324,160
Ensembl chr 2:111,317,873...111,324,174
|
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| G
|
Or51a42
|
olfactory receptor family 51 subfamily A member 42
|
increases expression
|
EXP
|
lead acetate results in increased expression of OR51A42 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:103,707,863...103,708,807
Ensembl chr 7:103,702,807...103,710,652
|
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| G
|
Or51e2
|
olfactory receptor family 51 subfamily E member 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of OLR59 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:102,389,928...102,408,678
Ensembl chr 7:102,387,718...102,408,678
|
|
| G
|
Or51l1
|
olfactory receptor family 51 subfamily L member 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of OR51L1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:102,783,583...102,784,530
Ensembl chr 7:102,783,583...102,784,530
|
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| G
|
Or52e7
|
olfactory receptor family 52 subfamily E member 7
|
increases expression
|
EXP
|
lead acetate results in increased expression of OR52E7 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:104,680,774...104,685,360
Ensembl chr 7:104,681,905...104,686,957
|
|
| G
|
Or55b4
|
olfactory receptor family 55 subfamily B member 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of OR55B4 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:102,133,321...102,137,514
Ensembl chr 7:102,131,238...102,137,520
|
|
| G
|
Or5ac21
|
olfactory receptor family 5 subfamily AC member 21
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR5AC21 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr16:59,123,518...59,124,438
Ensembl chr16:59,119,244...59,124,776
|
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| G
|
Or5g23
|
olfactory receptor family 5 subfamily G member 23
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR5G23 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:85,438,308...85,439,252
Ensembl chr 2:85,437,381...85,442,247
|
|
| G
|
Or5h26
|
olfactory receptor family 5 subfamily H member 26
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR5H26 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr16:58,987,575...58,992,475
Ensembl chr16:58,987,010...58,990,817
|
|
| G
|
Or5p50
|
olfactory receptor family 5 subfamily P member 50
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR5P50 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:107,421,730...107,422,674
Ensembl chr 7:107,419,773...107,424,748
|
|
| G
|
Or5p61
|
olfactory receptor family 5 subfamily P member 61
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR5P61 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:107,758,125...107,759,078
Ensembl chr 7:107,758,125...107,759,078
|
|
| G
|
Or6c205
|
olfactory receptor family 6 subfamily C member 205
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR6C205 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr10:129,086,405...129,087,343
Ensembl chr10:129,084,281...129,089,793
|
|
| G
|
Or6c206
|
olfactory receptor family 6 subfamily C member 206
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR6C206 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr10:129,096,832...129,097,770
Ensembl chr10:129,094,996...129,100,167
|
|
| G
|
Or7e165
|
olfactory receptor family 7 subfamily E member 165
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR7E165 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 9:19,691,579...19,695,360
Ensembl chr 9:19,691,579...19,696,629
|
|
| G
|
Or8c10
|
olfactory receptor family 8 subfamily C member 10
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OR8C10 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 9:38,278,844...38,279,839
Ensembl chr 9:38,278,192...38,282,651
|
|
| G
|
Or8j3
|
olfactory receptor family 8 subfamily J member 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of OR8J3 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:86,028,147...86,029,094
Ensembl chr 2:86,026,254...86,033,353
|
|
| G
|
Orai1
|
ORAI calcium release-activated calcium modulator 1
|
multiple interactions
|
EXP ISO
|
lead acetate inhibits the reaction [STIM1 protein binds to ORAI1 protein]
|
CTD |
PMID:38281554 |
|
NCBI chr 5:123,153,078...123,168,515
Ensembl chr 5:123,153,137...123,168,519
|
|
| G
|
Osgin1
|
oxidative stress induced growth inhibitor 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of OSGIN1 mRNA
|
CTD |
PMID:27562236 PMID:37939567 PMID:38568856 |
|
NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995
|
|
| G
|
Osm
|
oncostatin M
|
increases expression
|
EXP
|
lead acetate results in increased expression of OSM mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:4,186,831...4,191,027
Ensembl chr11:4,186,420...4,191,026
|
|
| G
|
Osmr
|
oncostatin M receptor
|
increases expression
|
EXP
|
lead acetate results in increased expression of OSMR mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr15:6,843,049...6,904,434
Ensembl chr15:6,843,058...6,904,450
|
|
| G
|
Ost4
|
oligosaccharyltransferase complex subunit 4 (non-catalytic)
|
increases expression
|
ISO
|
lead acetate results in increased expression of OST4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:31,063,860...31,065,155
Ensembl chr 5:31,063,229...31,065,132
|
|
| G
|
Ostc
|
oligosaccharyltransferase complex subunit (non-catalytic)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OSTC mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:130,489,566...130,503,093
Ensembl chr 3:130,489,561...130,503,093
|
|
| G
|
Otc
|
ornithine transcarbamylase
|
decreases expression increases expression
|
ISO EXP
|
lead acetate results in decreased expression of OTC mRNA lead acetate results in increased expression of OTC mRNA
|
CTD |
PMID:11578147 PMID:22609695 |
|
NCBI chr X:10,118,584...10,187,275
Ensembl chr X:10,118,544...10,187,263
|
|
| G
|
Otop3
|
otopetrin 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of OTOP3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:115,225,557...115,237,753
Ensembl chr11:115,225,557...115,237,753
|
|
| G
|
Otub1
|
OTU domain, ubiquitin aldehyde binding 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of OTUB1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:7,175,571...7,183,649
Ensembl chr19:7,175,567...7,183,681
|
|
| G
|
Otud5
|
OTU domain containing 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of OTUD5 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr X:7,705,852...7,742,861
Ensembl chr X:7,707,603...7,742,865
|
|
| G
|
Otulin
|
OTU deubiquitinase with linear linkage specificity
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of OTULIN intron
|
CTD |
PMID:33445541 |
|
NCBI chr15:27,606,005...27,630,793
Ensembl chr15:27,542,721...27,630,779
|
|
| G
|
Otx2
|
orthodenticle homeobox 2
|
decreases expression multiple interactions affects expression
|
ISO EXP
|
lead acetate results in decreased expression of OTX2 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of OTX2 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of OTX2 mRNA lead acetate affects the expression of OTX2 mRNA
|
CTD |
PMID:21864555 PMID:22641619 PMID:28050121 PMID:39150886 |
|
NCBI chr14:48,894,238...48,905,101
Ensembl chr14:48,895,134...48,911,276
|
|
| G
|
Oxct2a
|
3-oxoacid CoA transferase 2A
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of OXCT2A mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 4:123,215,668...123,217,472
Ensembl chr 4:123,215,668...123,217,427
|
|
| G
|
P2rx4
|
purinergic receptor P2X, ligand-gated ion channel 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of P2RX4 mRNA; lead acetate results in increased expression of P2RX4 protein
|
CTD |
PMID:26478469 PMID:29457680 |
|
NCBI chr 5:122,845,581...122,867,802
Ensembl chr 5:122,845,607...122,867,801
|
|
| G
|
P2rx7
|
purinergic receptor P2X, ligand-gated ion channel, 7
|
increases expression
|
ISO
|
lead acetate results in increased expression of P2RX7 mRNA; lead acetate results in increased expression of P2RX7 protein
|
CTD |
PMID:20932874 PMID:22641619 PMID:26478469 |
|
NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495
|
|
| G
|
P2ry1
|
purinergic receptor P2Y, G-protein coupled 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of P2RY1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:60,910,206...60,916,403
Ensembl chr 3:60,910,216...60,916,403
|
|
| G
|
P2ry6
|
pyrimidinergic receptor P2Y, G-protein coupled, 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of P2RY6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:100,586,837...100,628,528
Ensembl chr 7:100,586,837...100,623,856
|
|
| G
|
P4ha2
|
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of P4HA2 protein
|
CTD |
PMID:38072110 |
|
NCBI chr11:53,991,750...54,022,494
Ensembl chr11:53,990,921...54,022,491
|
|
| G
|
P4htm
|
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of P4HTM protein
|
CTD |
PMID:38072110 |
|
NCBI chr 9:108,456,025...108,475,482
Ensembl chr 9:108,456,061...108,474,866
|
|
| G
|
Pa2g4
|
proliferation-associated 2G4
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PA2G4 mRNA
|
CTD |
PMID:21335049 |
|
NCBI chr10:128,393,635...128,401,803
Ensembl chr10:128,393,635...128,401,856
|
|
| G
|
Pabpc6
|
poly(A) binding protein, cytoplasmic 6
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PABPC3 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr17:9,885,426...9,888,633
Ensembl chr17:9,885,424...9,888,646
|
|
| G
|
Pabpn1
|
poly(A) binding protein, nuclear 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PABPN1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr14:55,131,600...55,136,384
Ensembl chr14:55,129,957...55,135,626
|
|
| G
|
Pacc1
|
proton activated chloride channel 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PACC1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:191,058,099...191,083,481
Ensembl chr 1:191,058,109...191,083,111
|
|
| G
|
Pak4
|
p21 (RAC1) activated kinase 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of PAK4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:28,258,244...28,297,609
Ensembl chr 7:28,258,244...28,297,610
|
|
| G
|
Pals2
|
protein associated with LIN7 2, MAGUK family member
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PALS2 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 6:50,087,206...50,176,134
Ensembl chr 6:50,087,221...50,175,919
|
|
| G
|
Pantr1
|
POU domain, class 3, transcription factor 3 adjacent noncoding transcript 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of PANTR1 intron
|
CTD |
PMID:33445541 |
|
NCBI chr 1:42,687,360...42,733,985
Ensembl chr 1:42,629,754...42,734,584
|
|
| G
|
Panx2
|
pannexin 2
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of PANX2 mRNA; lead acetate results in increased expression of PANX2 protein PANX2 protein inhibits the reaction [lead acetate results in increased expression of GFAP mRNA]; PANX2 protein inhibits the reaction [lead acetate results in increased expression of MAP2 mRNA]; PANX2 protein inhibits the reaction [lead acetate results in increased expression of TUBB3 mRNA]; PANX2 protein promotes the reaction [lead acetate results in increased expression of OLIG2 mRNA]
|
CTD |
PMID:37939567 PMID:38568856 |
|
NCBI chr15:88,941,797...88,957,769
Ensembl chr15:88,943,937...88,957,770
|
|
| G
|
Papss2
|
3'-phosphoadenosine 5'-phosphosulfate synthase 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PAPSS2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr19:32,573,072...32,644,587
Ensembl chr19:32,573,190...32,644,587
|
|
| G
|
Parp1
|
poly (ADP-ribose) polymerase family, member 1
|
increases expression increases cleavage multiple interactions decreases expression
|
ISO EXP
|
lead acetate results in increased expression of PARP1 mRNA lead acetate results in increased cleavage of PARP1 protein 2-chloro-5-nitrobenzanilide inhibits the reaction [[lead acetate co-treated with Cadmium Chloride] results in increased expression of PARP1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[lead acetate co-treated with Cadmium Chloride] results in increased expression of PARP1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased expression of and results in increased cleavage of PARP1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased expression of PARP1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased expression of PARP1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [lead acetate results in increased cleavage of PARP1 protein]; 3-aminobenzamide inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased cleavage of PARP1 protein]; [lead acetate co-treated with Cadmium Chloride] results in increased expression of and results in increased cleavage of PARP1 protein; [lead acetate co-treated with Cadmium Chloride] results in increased expression of PARP1 mRNA; [lead acetate co-treated with sodium arsenite] results in increased expression of and results in increased cleavage of PARP1 protein; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased expression of and results in increased cleavage of PARP1 protein; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased expression of PARP1 mRNA; [sodium arsenite co-treated with lead acetate] results in increased expression of PARP1 mRNA; Cadmium Chloride inhibits the reaction [lead acetate results in increased cleavage of PARP1 protein]; CR8 compound analog inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PARP1 protein]; lead acetate results in increased expression of and results in increased cleavage of PARP1 protein; PPARG protein affects the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased expression of and results in increased cleavage of PARP1 protein]; PPARG protein affects the reaction [lead acetate results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PARP1 protein] lead acetate results in decreased expression of PARP1 mRNA
|
CTD |
PMID:21829687 PMID:28283887 |
|
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
|
|
| G
|
Parp4
|
poly (ADP-ribose) polymerase family, member 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PARP4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:56,812,982...56,897,256
Ensembl chr14:56,813,076...56,897,251
|
|
| G
|
Pax6
|
paired box 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of PAX6 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709
|
|
| G
|
Pbld1
|
phenazine biosynthesis-like protein domain containing 1
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of PBLD1 mRNA lead acetate results in increased expression of PBLD mRNA
|
CTD |
PMID:22609695 PMID:22641619 |
|
NCBI chr10:62,896,404...62,913,743
Ensembl chr10:62,895,941...62,913,741
|
|
| G
|
Pbx3
|
pre B cell leukemia homeobox 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PBX3 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:34,061,469...34,264,168
Ensembl chr 2:34,061,469...34,263,154
|
|
| G
|
Pbx4
|
pre B cell leukemia homeobox 4
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PBX4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:70,285,127...70,324,942
Ensembl chr 8:70,285,141...70,324,942
|
|
| G
|
Pbxip1
|
pre B cell leukemia transcription factor interacting protein 1
|
affects expression
|
ISO
|
lead acetate affects the expression of PBXIP1 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 3:89,343,982...89,358,259
Ensembl chr 3:89,344,013...89,358,259
|
|
| G
|
Pcbp2
|
poly(rC) binding protein 2
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of PCBP2 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr15:102,378,974...102,408,503
Ensembl chr15:102,378,974...102,408,496
|
|
| G
|
Pcdh18
|
protocadherin 18
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PCDH18 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 3:49,697,745...49,711,723
Ensembl chr 3:49,697,745...49,711,774
|
|
| G
|
Pcdh7
|
protocadherin 7
|
increases expression
|
EXP
|
lead acetate results in increased expression of PCDH7 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:57,873,487...58,290,578
Ensembl chr 5:57,875,309...58,290,572
|
|
| G
|
Pcdha1
|
protocadherin alpha 1
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of PCDHA1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr18:37,063,338...37,320,710
Ensembl chr18:37,063,237...37,320,714
|
|
| G
|
Pcdhb2
|
protocadherin beta 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of PCDHB2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr18:37,427,893...37,430,667
Ensembl chr18:37,427,865...37,430,677
|
|
| G
|
Pcdhb20
|
protocadherin beta 20
|
increases expression increases methylation
|
EXP ISO
|
lead acetate results in increased expression of PCDHB14 mRNA lead acetate results in increased methylation of PCDHB20 gene
|
CTD |
PMID:22609695 PMID:29571894 |
|
NCBI chr18:37,637,332...37,640,713
Ensembl chr18:37,637,317...37,640,875
|
|
| G
|
Pcdhb9
|
protocadherin beta 9
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PCDHB9 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr18:37,533,908...37,536,962
Ensembl chr18:37,533,908...37,536,962
|
|
| G
|
Pck2
|
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
|
increases expression
|
EXP
|
lead acetate results in increased expression of PCK2 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr14:55,777,721...55,787,477
Ensembl chr14:55,777,723...55,788,699
|
|
| G
|
Pcna
|
proliferating cell nuclear antigen
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PCNA mRNA
|
CTD |
PMID:33862172 |
|
NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
|
|
| G
|
Pcx
|
pyruvate carboxylase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PC mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780
|
|
| G
|
Pcyox1
|
prenylcysteine oxidase 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PCYOX1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:86,362,988...86,374,132
Ensembl chr 6:86,362,988...86,374,136
|
|
| G
|
Pcyt1b
|
phosphate cytidylyltransferase 1, choline, beta isoform
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of PCYT1B intron; [lead acetate results in increased abundance of Lead] which results in increased methylation of PCYT1B promoter
|
CTD |
PMID:33445541 |
|
NCBI chr X:92,698,469...92,793,557
Ensembl chr X:92,698,469...92,793,557
|
|
| G
|
Pde4dip
|
phosphodiesterase 4D interacting protein (myomegalin)
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PDE4DIP mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 3:97,597,144...97,796,023
Ensembl chr 3:97,597,140...97,796,023
|
|
| G
|
Pde5a
|
phosphodiesterase 5A, cGMP-specific
|
decreases methylation
|
ISO
|
lead acetate results in decreased methylation of PDE5A gene
|
CTD |
PMID:29571894 |
|
NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023
|
|
| G
|
Pdf
|
peptide deformylase (mitochondrial)
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PDF mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 8:107,772,921...107,775,246
Ensembl chr 8:107,771,330...107,775,246
|
|
| G
|
Pdgfb
|
platelet derived growth factor, B polypeptide
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of PDGFB exon; [lead acetate results in increased abundance of Lead] which results in increased methylation of PDGFB intron
|
CTD |
PMID:33445541 |
|
NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178
|
|
| G
|
Pdgfc
|
platelet-derived growth factor, C polypeptide
|
increases expression
|
EXP
|
lead acetate results in increased expression of PDGFC mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:80,943,723...81,121,347
Ensembl chr 3:80,943,723...81,121,347
|
|
| G
|
Pdgfd
|
platelet-derived growth factor, D polypeptide
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PDGFD mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:6,168,377...6,534,284
Ensembl chr 9:6,168,584...6,378,850
|
|
| G
|
Pdgfra
|
platelet derived growth factor receptor, alpha polypeptide
|
multiple interactions
|
ISO
|
CBL protein affects the reaction [lead acetate results in decreased expression of PDGFRA protein]; FYN protein affects the reaction [lead acetate results in decreased expression of PDGFRA protein]; lead acetate results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of PDGFRA protein [lead acetate results in increased abundance of Lead] which results in increased expression of PDGFRA mRNA
|
CTD |
PMID:17298174 PMID:32458983 |
|
NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876
|
|
| G
|
Pdia3
|
protein disulfide isomerase associated 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of PDIA3 protein
|
CTD |
PMID:20797405 |
|
NCBI chr 2:121,244,383...121,269,168
Ensembl chr 2:121,244,256...121,269,168
|
|
| G
|
Pdk1
|
pyruvate dehydrogenase kinase, isoenzyme 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PDK1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202
|
|
| G
|
Pdk4
|
pyruvate dehydrogenase kinase, isoenzyme 4
|
increases expression decreases expression
|
ISO
|
lead acetate results in increased expression of PDK4 mRNA lead acetate results in decreased expression of PDK4 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
|
|
| G
|
Pdlim1
|
PDZ and LIM domain 1 (elfin)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PDLIM1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr19:40,210,683...40,260,060
Ensembl chr19:40,209,617...40,260,286
|
|
| G
|
Pdlim2
|
PDZ and LIM domain 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PDLIM2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:70,401,667...70,415,140
Ensembl chr14:70,401,667...70,415,130
|
|
| G
|
Pdlim7
|
PDZ and LIM domain 7
|
increases expression
|
ISO
|
lead acetate results in increased expression of PDLIM7 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:55,645,300...55,661,281
Ensembl chr13:55,643,608...55,661,489
|
|
| G
|
Pdpk1
|
3-phosphoinositide dependent protein kinase 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PDPK1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898
|
|
| G
|
Pdxp
|
pyridoxal (pyridoxine, vitamin B6) phosphatase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PDXP mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr15:78,796,342...78,803,717
Ensembl chr15:78,798,119...78,803,717
|
|
| G
|
Pdyn
|
prodynorphin
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PDYN mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764
|
|
| G
|
Pdzk1ip1
|
PDZK1 interacting protein 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PDZK1IP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:114,945,905...114,951,091
Ensembl chr 4:114,945,905...114,951,096
|
|
| G
|
Pdzrn3
|
PDZ domain containing RING finger 3
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of PDZRN3 intron
|
CTD |
PMID:33445541 |
|
NCBI chr 6:101,126,568...101,354,858
Ensembl chr 6:101,126,570...101,354,858
|
|
| G
|
Pea15a
|
proliferation and apoptosis adaptor protein 15A
|
increases expression
|
ISO
|
lead acetate results in increased expression of PEA15 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:172,024,295...172,034,298
Ensembl chr 1:172,024,295...172,034,371
|
|
| G
|
Peli2
|
pellino 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of PELI2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr14:48,358,096...48,519,035
Ensembl chr14:48,358,280...48,519,032
|
|
| G
|
Pelp1
|
proline, glutamic acid and leucine rich protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PELP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:70,283,709...70,300,862
Ensembl chr11:70,283,709...70,300,857
|
|
| G
|
Per1
|
period circadian clock 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PER1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:68,985,934...69,000,791
Ensembl chr11:68,986,043...69,000,786
|
|
| G
|
Per2
|
period circadian clock 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PER2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046
|
|
| G
|
Pex2
|
peroxisomal biogenesis factor 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PEX2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:5,625,248...5,643,655
Ensembl chr 3:5,625,248...5,641,299
|
|
| G
|
Pex6
|
peroxisomal biogenesis factor 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of PEX6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:47,022,402...47,036,469
Ensembl chr17:47,022,389...47,036,467
|
|
| G
|
Pfdn5
|
prefoldin 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PFDN5 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:102,234,551...102,239,925
Ensembl chr15:102,234,551...102,240,308
|
|
| G
|
Pfkl
|
phosphofructokinase, liver, B-type
|
multiple interactions
|
EXP
|
[[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of PFKL mRNA; [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of PFKL protein
|
CTD |
PMID:38157908 |
|
NCBI chr10:77,822,781...77,845,641
Ensembl chr10:77,822,781...77,845,917
|
|
| G
|
Pfkm
|
phosphofructokinase, muscle
|
multiple interactions
|
EXP
|
[[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of PFKM mRNA; [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of PFKM protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of PFKM protein; [Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PFKM protein]
|
CTD |
PMID:34508822 PMID:38157908 |
|
NCBI chr15:97,990,470...98,030,328
Ensembl chr15:97,990,470...98,030,332
|
|
| G
|
Pfn3
|
profilin 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of PFN3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr13:55,562,501...55,563,045
Ensembl chr13:55,562,501...55,563,045
|
|
| G
|
Pgd
|
phosphogluconate dehydrogenase
|
increases expression decreases activity
|
ISO
|
lead acetate results in increased expression of PGD mRNA lead acetate results in decreased activity of PGD protein
|
CTD |
PMID:22641619 PMID:25228019 PMID:38568856 |
|
NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228
|
|
| G
|
Pgf
|
placental growth factor
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PGF mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr12:85,213,413...85,224,087
Ensembl chr12:85,213,409...85,224,564
|
|
| G
|
Pgk1
|
phosphoglycerate kinase 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PGK1 mRNA]; [lead acetate results in increased abundance of Lead] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of PGK1 protein]
|
CTD |
PMID:38157908 |
|
NCBI chr X:105,230,706...105,247,305
Ensembl chr X:105,230,706...105,247,305
|
|
| G
|
Pgm1
|
phosphoglucomutase 1
|
multiple interactions
|
EXP
|
[[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of PGM1 mRNA; [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of PGM1 protein
|
CTD |
PMID:38157908 |
|
NCBI chr 4:99,786,648...99,844,491
Ensembl chr 4:99,786,611...99,844,491
|
|
| G
|
Pgrmc2
|
progesterone receptor membrane component 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of PGRMC2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:41,020,772...41,037,443
Ensembl chr 3:41,020,761...41,037,481
|
|
| G
|
Phactr2
|
phosphatase and actin regulator 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PHACTR2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr10:13,083,461...13,350,266
Ensembl chr10:13,083,461...13,350,156
|
|
| G
|
Phf10
|
PHD finger protein 10
|
increases expression increases methylation
|
EXP ISO
|
lead acetate results in increased expression of PHF10 mRNA lead acetate results in increased methylation of PHF10 gene
|
CTD |
PMID:25270620 PMID:29571894 |
|
NCBI chr17:15,165,269...15,181,550
Ensembl chr17:15,165,271...15,181,535
|
|
| G
|
Phf8
|
PHD finger protein 8
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PHF8 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr X:150,303,621...150,416,855
Ensembl chr X:150,303,668...150,416,855
|
|
| G
|
Phka2
|
phosphorylase kinase alpha 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PHKA2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr X:159,284,900...159,384,772
Ensembl chr X:159,285,162...159,381,874
|
|
| G
|
Phkb
|
phosphorylase kinase beta
|
increases expression
|
ISO
|
lead acetate results in increased expression of PHKB mRNA; lead acetate results in increased expression of PHKB protein
|
CTD |
PMID:28916327 |
|
NCBI chr 8:86,567,489...86,790,883
Ensembl chr 8:86,567,588...86,788,005
|
|
| G
|
Phlda1
|
pleckstrin homology like domain, family A, member 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PHLDA1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:111,342,147...111,344,510
Ensembl chr10:111,342,147...111,344,506
|
|
| G
|
Phlda2
|
pleckstrin homology like domain, family A, member 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of PHLDA2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:143,055,282...143,056,882
Ensembl chr 7:143,055,282...143,056,887
|
|
| G
|
Phrf1
|
PHD and ring finger domains 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PHRF1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:140,808,373...140,842,664
Ensembl chr 7:140,808,697...140,842,663
|
|
| G
|
Pi16
|
peptidase inhibitor 16
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of PI16 5' UTR; [lead acetate results in increased abundance of Lead] which results in increased methylation of PI16 exon; [lead acetate results in increased abundance of Lead] which results in increased methylation of PI16 intron; [lead acetate results in increased abundance of Lead] which results in increased methylation of PI16 promoter
|
CTD |
PMID:33445541 |
|
NCBI chr17:29,537,770...29,547,876
Ensembl chr17:29,536,654...29,549,567
|
|
| G
|
Pibf1
|
progesterone immunomodulatory binding factor 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PIBF1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:99,336,892...99,492,335
Ensembl chr14:99,336,860...99,491,929
|
|
| G
|
Pidd1
|
p53 induced death domain protein 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PIDD1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:141,018,026...141,027,477
Ensembl chr 7:141,018,026...141,023,938
|
|
| G
|
Pigk
|
phosphatidylinositol glycan anchor biosynthesis, class K
|
increases expression
|
ISO
|
lead acetate results in increased expression of PIGK mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:152,419,718...152,548,705
Ensembl chr 3:152,419,737...152,686,045
|
|
| G
|
Pik3ca
|
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
|
decreases phosphorylation multiple interactions
|
EXP
|
lead acetate results in decreased phosphorylation of PIK3CA protein 3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in decreased phosphorylation of PIK3CA protein]
|
CTD |
PMID:37385299 |
|
NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635
|
|
| G
|
Pik3cd
|
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PIK3CD mRNA
|
CTD |
PMID:33932463 |
|
NCBI chr 4:149,733,625...149,787,023
Ensembl chr 4:149,733,625...149,787,028
|
|
| G
|
Pik3cg
|
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of PIK3CG mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of PIK3CG protein
|
CTD |
PMID:36652739 |
|
NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658
|
|
| G
|
Pik3r1
|
phosphoinositide-3-kinase regulatory subunit 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PIK3R1 mRNA
|
CTD |
PMID:30980912 |
|
NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725
|
|
| G
|
Pim1
|
proviral integration site 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PIM1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:29,709,759...29,715,085
Ensembl chr17:29,709,727...29,715,086
|
|
| G
|
Pink1
|
PTEN induced putative kinase 1
|
multiple interactions
|
ISO
|
[[amyloid beta-protein (25-35) co-treated with amyloid beta-protein (1-40)] co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of PINK1 mRNA; [amyloid beta-protein (1-40) co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of PINK1 mRNA; [amyloid beta-protein (1-40) co-treated with amyloid beta-protein (25-35)] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PINK1 protein]; [amyloid beta-protein (25-35) co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of PINK1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of PINK1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of PINK1 protein; amyloid beta-protein (1-40) promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PINK1 protein]; amyloid beta-protein (25-35) promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PINK1 protein]; lead acetate promotes the reaction [PINK1 protein binds to ATM protein]; lead acetate results in increased expression of and results in increased phosphorylation of PINK1 protein
|
CTD |
PMID:29660402 PMID:35300571 |
|
NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618
|
|
| G
|
Pip
|
prolactin induced protein
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PIP mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:41,824,483...41,828,999
Ensembl chr 6:41,824,469...41,828,999
|
|
| G
|
Pip5k1b
|
phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of PIP5K1B mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr19:24,272,158...24,533,236
Ensembl chr19:24,272,158...24,533,236
|
|
| G
|
Pir
|
pirin
|
increases expression
|
ISO
|
lead acetate results in increased expression of PIR mRNA
|
CTD |
PMID:22839698 PMID:27562236 PMID:37939567 PMID:38568856 |
|
NCBI chr X:163,052,427...163,156,009
Ensembl chr X:163,052,367...163,156,007
|
|
| G
|
Pitpnc1
|
phosphatidylinositol transfer protein, cytoplasmic 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of PITPNC1 intron
|
CTD |
PMID:33445541 |
|
NCBI chr11:107,098,718...107,361,546
Ensembl chr11:107,098,718...107,361,525
|
|
| G
|
Pkd1l3
|
polycystic kidney disease 1 like 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of PKD1L3 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 8:110,340,828...110,399,305
Ensembl chr 8:110,341,149...110,401,018
|
|
| G
|
Pkmyt1
|
protein kinase, membrane associated tyrosine/threonine 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PKMYT1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:23,945,385...23,955,709
Ensembl chr17:23,945,310...23,955,709
|
|
| G
|
Pkp1
|
plakophilin 1
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of PKP1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 1:135,799,132...135,846,945
Ensembl chr 1:135,799,133...135,846,945
|
|
| G
|
Pkp2
|
plakophilin 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PKP2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr16:16,031,209...16,090,576
Ensembl chr16:16,031,182...16,090,576
|
|
| G
|
Pla2g1b
|
phospholipase A2, group IB, pancreas
|
increases expression
|
ISO EXP
|
lead acetate results in increased expression of PLA2G1B mRNA
|
CTD |
PMID:11578147 PMID:20542052 |
|
NCBI chr 5:115,604,201...115,612,781
Ensembl chr 5:115,604,321...115,612,781
|
|
| G
|
Pla2g2a
|
phospholipase A2, group IIA (platelets, synovial fluid)
|
increases expression
|
ISO
|
lead acetate results in increased expression of PLA2G2A mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497
|
|
| G
|
Pla2g2d
|
phospholipase A2, group IID
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PLA2G2D mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 4:138,503,046...138,509,363
Ensembl chr 4:138,503,046...138,509,357
|
|
| G
|
Pla2g5
|
phospholipase A2, group V
|
affects expression decreases expression
|
ISO
|
lead acetate affects the expression of PLA2G5 mRNA lead acetate results in decreased expression of PLA2G5 mRNA
|
CTD |
PMID:21864555 PMID:22641619 |
|
NCBI chr 4:138,526,558...138,590,784
Ensembl chr 4:138,526,555...138,590,793
|
|
| G
|
Pla2r1
|
phospholipase A2 receptor 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PLA2R1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:60,247,887...60,383,669
Ensembl chr 2:60,247,887...60,383,652
|
|
| G
|
Plac8
|
placenta-specific 8
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PLAC8 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:100,699,455...100,720,119
Ensembl chr 5:100,701,591...100,720,111
|
|
| G
|
Plagl1
|
pleiomorphic adenoma gene-like 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PLAGL1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr10:12,966,576...13,007,438
Ensembl chr10:12,936,248...13,007,438
|
|
| G
|
Plat
|
plasminogen activator, tissue
|
affects activity
|
ISO
|
lead acetate affects the activity of PLAT protein
|
CTD |
PMID:2143947 |
|
NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
|
|
| G
|
Plce1
|
phospholipase C, epsilon 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of PLCE1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr19:38,469,438...38,773,549
Ensembl chr19:38,469,557...38,773,474
|
|
| G
|
Pld2
|
phospholipase D2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PLD2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:70,430,318...70,448,936
Ensembl chr11:70,430,890...70,448,936
|
|
| G
|
Pld4
|
phospholipase D family member 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of PLD4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr12:112,727,089...112,735,420
Ensembl chr12:112,727,089...112,735,424
|
|
| G
|
Pld5
|
phospholipase D family member 5
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of PLD5 mRNA lead acetate results in increased expression of PLD5 mRNA
|
CTD |
PMID:22613225 PMID:38568856 |
|
NCBI chr 1:175,789,867...176,109,078
Ensembl chr 1:175,789,872...176,102,878
|
|
| G
|
Plec
|
plectin
|
increases expression
|
ISO
|
lead acetate results in increased expression of PLEC mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:76,055,174...76,115,578
Ensembl chr15:76,055,174...76,116,774
|
|
| G
|
Plekho1
|
pleckstrin homology domain containing, family O member 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PLEKHO1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:95,896,110...95,903,258
Ensembl chr 3:95,895,741...95,903,313
|
|
| G
|
Plg
|
plasminogen
|
affects activity
|
ISO
|
lead acetate affects the activity of PLG protein modified form
|
CTD |
PMID:2143947 |
|
NCBI chr17:12,597,496...12,638,271
Ensembl chr17:12,597,495...12,638,272
|
|
| G
|
Plin2
|
perilipin 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of PLIN2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297
|
|
| G
|
Plin5
|
perilipin 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PLIN5 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr17:56,418,601...56,424,606
Ensembl chr17:56,418,601...56,424,596
|
|
| G
|
Plk4
|
polo like kinase 4
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of PLK4 mRNA lead acetate results in increased expression of PLK4 mRNA
|
CTD |
PMID:21829687 PMID:22641619 |
|
NCBI chr 3:40,754,463...40,771,318
Ensembl chr 3:40,754,454...40,771,318
|
|
| G
|
Pln
|
phospholamban
|
increases expression
|
ISO
|
lead acetate results in increased expression of PLN mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr10:53,213,782...53,222,095
Ensembl chr10:53,213,763...53,222,083
|
|
| G
|
Plod2
|
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of PLOD2 mRNA [sodium arsenite co-treated with lead acetate] results in decreased expression of PLOD2 protein
|
CTD |
PMID:22641619 PMID:38072110 |
|
NCBI chr 9:92,421,828...92,490,481
Ensembl chr 9:92,424,276...92,490,481
|
|
| G
|
Plp1
|
proteolipid protein (myelin) 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] affects the expression of PLP1 protein
|
CTD |
PMID:23680456 |
|
NCBI chr X:135,720,897...135,739,331
Ensembl chr X:135,723,420...135,740,482
|
|
| G
|
Plpp1
|
phospholipid phosphatase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PLPP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:112,937,311...113,004,428
Ensembl chr13:112,937,326...113,004,428
|
|
| G
|
Plpp3
|
phospholipid phosphatase 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of PLPP3 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 4:105,014,544...105,089,964
Ensembl chr 4:105,014,544...105,089,961
|
|
| G
|
Plpp4
|
phospholipid phosphatase 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PLPP4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:128,858,114...128,993,138
Ensembl chr 7:128,858,755...128,993,136
|
|
| G
|
Plxna1
|
plexin A1
|
decreases expression
|
EXP ISO
|
lead acetate results in decreased expression of PLXNA1 mRNA
|
CTD |
PMID:20542052 PMID:22641619 |
|
NCBI chr 6:89,293,295...89,339,595
Ensembl chr 6:89,293,296...89,339,602
|
|
| G
|
Plxna2
|
plexin A2
|
increases expression
|
ISO
|
lead acetate results in increased expression of PLXNA2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:194,302,020...194,499,177
Ensembl chr 1:194,300,526...194,499,177
|
|
| G
|
Pm20d2
|
peptidase M20 domain containing 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PM20D2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:33,170,309...33,189,732
Ensembl chr 4:33,174,230...33,189,737
|
|
| G
|
Pmaip1
|
phorbol-12-myristate-13-acetate-induced protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PMAIP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636
|
|
| G
|
Pmel
|
premelanosome protein
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PMEL mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr10:128,531,757...128,555,993
Ensembl chr10:128,540,064...128,556,107
|
|
| G
|
Pmepa1
|
prostate transmembrane protein, androgen induced 1
|
increases expression affects methylation
|
ISO
|
lead acetate results in increased expression of PMEPA1 mRNA lead acetate affects the methylation of PMEPA1 gene
|
CTD |
PMID:29571894 PMID:37939567 |
|
NCBI chr 2:173,066,251...173,118,329
Ensembl chr 2:173,066,251...173,118,326
|
|
| G
|
Pmm2
|
phosphomannomutase 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of PMM2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr16:8,455,467...8,475,472
Ensembl chr16:8,455,538...8,480,331
|
|
| G
|
Pnlip
|
pancreatic lipase
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of PNLIP mRNA
|
CTD |
PMID:20542052 PMID:22641619 |
|
NCBI chr19:58,658,797...58,670,231
Ensembl chr19:58,640,930...58,670,220
|
|
| G
|
Pnmt
|
phenylethanolamine-N-methyltransferase
|
increases expression
|
EXP
|
lead acetate results in increased expression of PNMT mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:98,277,449...98,279,006
Ensembl chr11:98,277,276...98,279,007
|
|
| G
|
Pnpla1
|
patatin-like phospholipase domain containing 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PNPLA1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr17:29,077,262...29,109,282
Ensembl chr17:29,077,385...29,109,283
|
|
| G
|
Pnrc1
|
proline-rich nuclear receptor coactivator 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PNRC1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:33,245,423...33,248,787
Ensembl chr 4:33,245,423...33,290,163
|
|
| G
|
Pnrc2
|
proline-rich nuclear receptor coactivator 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PNRC2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:135,598,229...135,601,157
Ensembl chr 4:135,598,229...135,601,161
|
|
| G
|
Pold1
|
polymerase (DNA directed), delta 1, catalytic subunit
|
multiple interactions increases expression
|
ISO EXP
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of POLD1 protein lead acetate results in increased expression of POLD1 mRNA
|
CTD |
PMID:21829687 PMID:38072110 |
|
NCBI chr 7:44,182,168...44,198,239
Ensembl chr 7:44,182,170...44,198,273
|
|
| G
|
Pole
|
polymerase (DNA directed), epsilon
|
increases expression
|
EXP
|
lead acetate results in increased expression of POLE mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:110,434,185...110,485,319
Ensembl chr 5:110,434,172...110,485,340
|
|
| G
|
Pole4
|
polymerase (DNA-directed), epsilon 4 (p12 subunit)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of POLE4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:82,593,513...82,629,985
Ensembl chr 6:82,595,973...82,682,346
|
|
| G
|
Polq
|
polymerase (DNA directed), theta
|
increases expression
|
ISO
|
lead acetate results in increased expression of POLQ mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr16:36,832,104...36,922,321
Ensembl chr16:36,832,148...36,915,779
|
|
| G
|
Polr1h
|
RNA polymerase I subunit H
|
increases expression
|
ISO
|
lead acetate results in increased expression of ZNRD1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:37,265,250...37,269,417
Ensembl chr17:37,265,248...37,269,451
|
|
| G
|
Polr3k
|
polymerase (RNA) III (DNA directed) polypeptide K
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of POLR3K mRNA [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of POLR3K mRNA
|
CTD |
PMID:22641619 PMID:22839698 |
|
NCBI chr 2:181,506,153...181,512,623
Ensembl chr 2:181,506,130...181,512,623
|
|
| G
|
Pomp
|
proteasome maturation protein
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of POMP protein
|
CTD |
PMID:38072110 |
|
NCBI chr 5:147,797,438...147,812,594
Ensembl chr 5:147,797,271...147,813,266
|
|
| G
|
Pon1
|
paraoxonase 1
|
affects expression
|
ISO
|
lead acetate affects the expression of PON1 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946
|
|
| G
|
Pon2
|
paraoxonase 2
|
increases expression multiple interactions decreases activity
|
ISO
|
lead acetate results in increased expression of PON2 mRNA Calcium inhibits the reaction [lead acetate results in decreased activity of PON2 protein]
|
CTD |
PMID:22271317 |
|
NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455
|
|
| G
|
Pop5
|
processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)
|
increases expression
|
EXP
|
lead acetate results in increased expression of POP5 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:115,373,505...115,379,031
Ensembl chr 5:115,373,895...115,383,410
|
|
| G
|
Popdc3
|
popeye domain containing 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of POPDC3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:45,165,401...45,194,546
Ensembl chr10:45,054,194...45,194,548
|
|
| G
|
Por
|
cytochrome p450 oxidoreductase
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of POR mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180
|
|
| G
|
Porcn
|
porcupine O-acyltransferase
|
multiple interactions
|
EXP
|
[[lead acetate results in increased abundance of Lead] which results in decreased expression of PORCN protein] which results in decreased localization of WNT3A protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of PORCN mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of PORCN protein
|
CTD |
PMID:37436718 |
|
NCBI chr X:8,060,085...8,072,794
Ensembl chr X:8,060,087...8,072,764
|
|
| G
|
Postn
|
periostin, osteoblast specific factor
|
increases expression
|
ISO
|
lead acetate results in increased expression of POSTN mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458
|
|
| G
|
Pou2f2
|
POU domain, class 2, transcription factor 2
|
increases activity increases expression
|
ISO
|
lead acetate results in increased activity of POU2F2 protein lead acetate results in increased expression of POU2F2 mRNA; lead acetate results in increased expression of POU2F2 protein
|
CTD |
PMID:17093203 |
|
NCBI chr 7:24,790,111...24,879,292
Ensembl chr 7:24,786,769...24,879,151
|
|
| G
|
Pou4f1
|
POU domain, class 4, transcription factor 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of POU4F1 mRNA; lead acetate results in decreased expression of POU4F1 protein
|
CTD |
PMID:16384672 |
|
NCBI chr14:104,699,111...104,705,554
Ensembl chr14:104,699,112...104,705,435
|
|
| G
|
Pou4f2
|
POU domain, class 4, transcription factor 2
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of POU4F2 mRNA [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of POU4F2 protein
|
CTD |
PMID:20542052 PMID:23680456 |
|
NCBI chr 8:79,159,638...79,163,276
Ensembl chr 8:79,159,639...79,163,274
|
|
| G
|
Pou5f1
|
POU domain, class 5, transcription factor 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of POU5F1 mRNA
|
CTD |
PMID:31715224 |
|
NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669
|
|
| G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
increases expression
|
EXP
|
lead acetate results in increased expression of PPARA mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
|
|
| G
|
Pparg
|
peroxisome proliferator activated receptor gamma
|
multiple interactions increases expression
|
ISO
|
[[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of and results in increased activity of PPARG protein] which results in decreased expression of GFAP protein; [lead acetate co-treated with Cadmium Chloride] results in increased expression of PPARG protein; [lead acetate co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased expression of PPARG protein; [lead acetate co-treated with sodium arsenite] results in increased expression of PPARG protein; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] promotes the reaction [CDK5 protein results in increased phosphorylation of PPARG protein]; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] promotes the reaction [PPARG protein binds to GFAP promoter]; [sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of and results in increased activity of PPARG protein; CR8 compound analog inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PPARG protein]; CR8 compound inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of PPARG protein]; PPARG protein affects the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased expression of and results in increased cleavage of PARP1 protein]; PPARG protein affects the reaction [lead acetate results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of PPARG protein]; T 0070907 inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of PPARG protein]; T 0070907 inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of PPARG protein] lead acetate results in increased expression of PPARG protein
|
CTD |
PMID:24481447 PMID:28283887 |
|
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
|
|
| G
|
Ppargc1a
|
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
|
increases expression multiple interactions
|
EXP
|
lead acetate results in increased expression of PPARGC1A protein PPARGC1A protein affects the reaction [lead acetate results in increased expression of SIRT3 protein]; PPARGC1A protein inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; PPARGC1A protein inhibits the reaction [lead acetate results in increased activity of CASP9 protein]
|
CTD |
PMID:27236077 |
|
NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
|
|
| G
|
Ppcdc
|
phosphopantothenoylcysteine decarboxylase
|
increases expression
|
EXP
|
lead acetate results in increased expression of PPCDC mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:57,292,378...57,347,440
Ensembl chr 9:57,292,378...57,347,407
|
|
| G
|
Ppcs
|
phosphopantothenoylcysteine synthetase
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PPCS mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:119,275,724...119,279,673
Ensembl chr 4:119,275,727...119,279,617
|
|
| G
|
Ppdpf
|
pancreatic progenitor cell differentiation and proliferation factor
|
increases expression
|
ISO
|
lead acetate results in increased expression of PPDPF mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:180,828,615...180,830,297
Ensembl chr 2:180,829,040...180,830,564
|
|
| G
|
Ppef1
|
protein phosphatase with EF hand calcium-binding domain 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PPEF1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr X:159,404,997...159,534,286
Ensembl chr X:159,406,090...159,518,761
|
|
| G
|
Ppef2
|
protein phosphatase, EF hand calcium-binding domain 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PPEF2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:92,374,109...92,404,759
Ensembl chr 5:92,374,538...92,404,137
|
|
| G
|
Ppif
|
peptidylprolyl isomerase F (cyclophilin F)
|
multiple interactions
|
ISO
|
PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 mRNA]; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 protein]; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A3 mRNA]; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A3 protein]; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of RPTOR protein]; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of AIFM1 protein]; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein]
|
CTD |
PMID:31874198 |
|
NCBI chr14:25,693,998...25,700,892
Ensembl chr14:25,694,578...25,700,892
|
|
| G
|
Ppil1
|
peptidylprolyl isomerase (cyclophilin)-like 1
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of PPIL1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr17:29,469,809...29,482,945
Ensembl chr17:29,469,777...29,483,160
|
|
| G
|
Ppl
|
periplakin
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PPL mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr16:4,904,155...4,950,345
Ensembl chr16:4,904,155...4,950,285
|
|
| G
|
Ppm1g
|
protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PPM1G mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:31,360,012...31,377,889
Ensembl chr 5:31,360,008...31,378,031
|
|
| G
|
Ppp1ca
|
protein phosphatase 1 catalytic subunit alpha
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of PPP1CA gene
|
CTD |
PMID:29571894 |
|
NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419
|
|
| G
|
Ppp1cb
|
protein phosphatase 1 catalytic subunit beta
|
increases expression decreases methylation
|
EXP ISO
|
lead acetate results in increased expression of PPP1CB mRNA lead acetate results in decreased methylation of PPP1CB gene
|
CTD |
PMID:22609695 PMID:29571894 |
|
NCBI chr 5:32,616,192...32,651,057
Ensembl chr 5:32,616,187...32,674,777
|
|
| G
|
Ppp1r12a
|
protein phosphatase 1, regulatory subunit 12A
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of PPP1R12A mRNA; PPP1R12A protein affects the reaction [[lead acetate results in increased abundance of Lead] which affects the localization of HDAC4 protein]
|
CTD |
PMID:33080273 |
|
NCBI chr10:107,997,913...108,115,846
Ensembl chr10:107,998,054...108,120,336
|
|
| G
|
Ppp1r18
|
protein phosphatase 1, regulatory subunit 18
|
increases expression
|
ISO
|
lead acetate results in increased expression of PPP1R18 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:36,176,483...36,186,488
Ensembl chr17:36,176,485...36,186,488
|
|
| G
|
Ppp1r9b
|
protein phosphatase 1, regulatory subunit 9B
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PPP1R9B mRNA
|
CTD |
PMID:22160880 |
|
NCBI chr11:94,882,038...94,897,724
Ensembl chr11:94,881,861...94,897,725
|
|
| G
|
Ppp2ca
|
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of PPP2CA mRNA
|
CTD |
PMID:33080273 |
|
NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605
|
|
| G
|
Ppp3r1
|
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
|
increases expression
|
ISO
|
lead acetate results in increased expression of PPP3R1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr11:17,109,298...17,150,380
Ensembl chr11:17,109,263...17,150,375
|
|
| G
|
Ppp5c
|
protein phosphatase 5, catalytic subunit
|
increases expression
|
ISO
|
lead acetate results in increased expression of PPP5C protein
|
CTD |
PMID:23134599 |
|
NCBI chr 7:16,738,575...16,761,812
Ensembl chr 7:16,738,565...16,761,849
|
|
| G
|
Ppp6r3
|
protein phosphatase 6, regulatory subunit 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PPP6R3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:3,504,928...3,626,191
Ensembl chr19:3,504,928...3,625,749
|
|
| G
|
Prdm14
|
PR domain containing 14
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PRDM14 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 1:13,183,649...13,197,467
Ensembl chr 1:13,183,681...13,197,387
|
|
| G
|
Prdx1
|
peroxiredoxin 1
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of PRDX1 mRNA lead acetate results in increased expression of PRDX1 mRNA
|
CTD |
PMID:21829687 PMID:33862172 |
|
NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019
|
|
| G
|
Prdx2
|
peroxiredoxin 2
|
multiple interactions affects localization
|
EXP ISO
|
[S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]]; Clotrimazole inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]]; lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]; S-allylcysteine inhibits the reaction [lead acetate affects the localization of PRDX2 protein]; S-allylcysteine inhibits the reaction [lead acetate promotes the reaction [PRDX2 protein binds to PRDX2 protein]] [lead acetate co-treated with zinc protoporphyrin] results in increased expression of PRDX2 mRNA
|
CTD |
PMID:22033380 PMID:22839698 |
|
NCBI chr 8:85,696,251...85,701,440
Ensembl chr 8:85,696,216...85,701,463
|
|
| G
|
Prdx4
|
peroxiredoxin 4
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PRDX4 mRNA
|
CTD |
PMID:29746905 |
|
NCBI chr X:154,106,914...154,125,268
Ensembl chr X:154,106,914...154,123,750
|
|
| G
|
Prelp
|
proline arginine-rich end leucine-rich repeat
|
increases expression
|
EXP
|
lead acetate results in increased expression of PRELP mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:133,838,042...133,857,820
Ensembl chr 1:133,838,042...133,849,152
|
|
| G
|
Prickle3
|
prickle planar cell polarity protein 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of PRICKLE3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr X:7,523,616...7,535,086
Ensembl chr X:7,523,499...7,534,425
|
|
| G
|
Prkaa2
|
protein kinase, AMP-activated, alpha 2 catalytic subunit
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of PRKAA2 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087
|
|
| G
|
Prkaca
|
protein kinase, cAMP dependent, catalytic, alpha
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PRKACA protein
|
CTD |
PMID:25981801 |
|
NCBI chr 8:84,699,607...84,723,073
Ensembl chr 8:84,699,622...84,723,072
|
|
| G
|
Prkar1a
|
protein kinase, cAMP dependent regulatory, type I, alpha
|
increases expression
|
EXP
|
lead acetate results in increased expression of PRKAR1A mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:109,539,849...109,560,489
Ensembl chr11:109,540,231...109,560,482
|
|
| G
|
Prkca
|
protein kinase C, alpha
|
decreases expression increases phosphorylation multiple interactions increases expression
|
ISO EXP
|
lead acetate results in decreased expression of PRKCA protein lead acetate results in increased phosphorylation of PRKCA protein [lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of PRKCA mRNA; Genistein inhibits the reaction [lead acetate results in increased phosphorylation of PRKCA protein]; Nimodipine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein]; Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein]; Tetradecanoylphorbol Acetate inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein] lead acetate results in increased expression of PRKCA mRNA 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased activity of PRKCA protein]; [lead acetate results in decreased expression of PRKCA protein] inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [lead acetate results in decreased expression of PRKCA protein] inhibits the reaction [lead acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; EGFR mutant form inhibits the reaction [lead acetate results in increased activity of PRKCA protein]; lead acetate results in increased activity of and affects the localization of PRKCA protein; PRKCA mutant form inhibits the reaction [lead acetate results in increased activity of HRAS protein]; SU 6656 inhibits the reaction [lead acetate results in increased activity of PRKCA protein]
|
CTD |
PMID:11861786 PMID:16547843 PMID:19133285 PMID:22609695 PMID:25981801 PMID:26797587 PMID:36925031 More...
|
|
NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
|
|
| G
|
Prkcb
|
protein kinase C, beta
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PRKCB protein
|
CTD |
PMID:16547843 |
|
NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625
|
|
| G
|
Prkce
|
protein kinase C, epsilon
|
decreases expression multiple interactions
|
ISO EXP
|
lead acetate results in decreased expression of PRKCE protein [lead acetate results in increased abundance of Lead] which results in increased methylation of PRKCE intron
|
CTD |
PMID:16547843 PMID:33445541 |
|
NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
|
|
| G
|
Prkcg
|
protein kinase C, gamma
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PRKCG protein
|
CTD |
PMID:16547843 |
|
NCBI chr 7:3,352,038...3,379,615
Ensembl chr 7:3,337,704...3,379,615
|
|
| G
|
Prkch
|
protein kinase C, eta
|
increases expression
|
EXP
|
lead acetate results in increased expression of PRKCH mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr12:73,631,570...73,824,959
Ensembl chr12:73,631,570...73,824,959
|
|
| G
|
Prkci
|
protein kinase C, iota
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PRKCI protein
|
CTD |
PMID:16547843 |
|
NCBI chr 3:31,049,893...31,106,889
Ensembl chr 3:31,049,896...31,107,108
|
|
| G
|
Prkcq
|
protein kinase C, theta
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PRKCQ mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:11,176,922...11,306,033
Ensembl chr 2:11,176,919...11,306,033
|
|
| G
|
Prkdc
|
protein kinase, DNA activated, catalytic polypeptide
|
increases expression
|
EXP
|
lead acetate results in increased expression of PRKDC mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099
|
|
| G
|
Prkg1
|
protein kinase, cGMP-dependent, type I
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of PRKG1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433
|
|
| G
|
Prkn
|
parkin RBR E3 ubiquitin protein ligase
|
multiple interactions affects localization
|
EXP ISO
|
lead acetate results in increased phosphorylation of and affects the localization of PRKN protein [[amyloid beta-protein (25-35) co-treated with amyloid beta-protein (1-40)] co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of PRKN protein; [[lead acetate results in increased abundance of Lead] co-treated with [amyloid beta-protein (1-40) co-treated with amyloid beta-protein (25-35)]] results in decreased expression of PRKN mRNA; [[lead acetate results in increased abundance of Lead] which co-treated with amyloid beta-protein (1-40)] results in decreased expression of PRKN mRNA; [[lead acetate results in increased abundance of Lead] which co-treated with amyloid beta-protein (1-40)] results in decreased expression of PRKN protein; [[lead acetate results in increased abundance of Lead] which co-treated with amyloid beta-protein (25-35)] results in decreased expression of PRKN mRNA; [[lead acetate results in increased abundance of Lead] which co-treated with amyloid beta-protein (25-35)] results in decreased expression of PRKN protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of PRKN mRNA lead acetate affects the localization of PRKN protein
|
CTD |
PMID:29660402 PMID:35300571 |
|
NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248
|
|
| G
|
Prkra
|
protein kinase, interferon inducible double stranded RNA dependent activator
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of PRKRA protein
|
CTD |
PMID:38072110 |
|
NCBI chr 2:76,436,385...76,478,614
Ensembl chr 2:76,460,242...76,478,359
|
|
| G
|
Prl2c2
|
prolactin family 2, subfamily c, member 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PRL2C2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr13:13,170,705...13,179,978
Ensembl chr13:13,170,710...13,179,968
|
|
| G
|
Prl2c5
|
prolactin family 2, subfamily c, member 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PRL2C5 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr13:13,357,288...13,366,515
Ensembl chr13:13,357,300...13,366,508
|
|
| G
|
Prl7c1
|
prolactin family 7, subfamily c, member 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PRL7C1 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr13:27,957,583...27,964,829
Ensembl chr13:27,957,478...27,964,787
|
|
| G
|
Prlr
|
prolactin receptor
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PRLR mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr15:10,177,324...10,349,276
Ensembl chr15:10,177,324...10,349,266
|
|
| G
|
Prnp
|
prion protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of PRNP mRNA
|
CTD |
PMID:29746905 |
|
NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349
|
|
| G
|
Procr
|
protein C receptor, endothelial
|
increases expression
|
EXP
|
lead acetate results in increased expression of PROCR mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:155,592,159...155,597,391
Ensembl chr 2:155,593,037...155,597,391
|
|
| G
|
Prokr2
|
prokineticin receptor 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PROKR2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:132,211,625...132,227,413
Ensembl chr 2:132,179,653...132,227,367
|
|
| G
|
Prol1
|
proline rich, lacrimal 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of PROL1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:88,465,171...88,476,676
Ensembl chr 5:88,465,171...88,476,673
|
|
| G
|
Prom1
|
prominin 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PROM1 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374
|
|
| G
|
Prpf19
|
pre-mRNA processing factor 19
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of PRPF19 intron
|
CTD |
PMID:33445541 |
|
NCBI chr19:10,872,595...10,886,923
Ensembl chr19:10,872,595...10,886,923
|
|
| G
|
Prph2
|
peripherin 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PRPH2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr17:47,221,404...47,235,859
Ensembl chr17:47,221,385...47,235,859
|
|
| G
|
Prps1
|
phosphoribosyl pyrophosphate synthetase 1
|
affects expression
|
ISO
|
lead acetate affects the expression of PRPS1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr X:139,357,352...139,376,889
Ensembl chr X:139,357,362...139,376,889
|
|
| G
|
Prpsap2
|
phosphoribosyl pyrophosphate synthetase-associated protein 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of PRPSAP2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:61,620,476...61,652,924
Ensembl chr11:61,620,476...61,652,914
|
|
| G
|
Prr11
|
proline rich 11
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of PRR11 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr11:86,979,982...86,999,540
Ensembl chr11:86,979,979...86,999,534
|
|
| G
|
Prr15l
|
proline rich 15-like
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PRR15L mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:96,816,987...96,826,474
Ensembl chr11:96,818,930...96,828,656
|
|
| G
|
Prr5
|
proline rich 5 (renal)
|
increases expression
|
ISO
|
lead acetate results in increased expression of PRR5 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr15:84,547,407...84,590,610
Ensembl chr15:84,553,821...84,587,874
|
|
| G
|
Prrg2
|
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of PRRG2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:44,703,008...44,711,828
Ensembl chr 7:44,703,008...44,712,101
|
|
| G
|
Prrt1
|
proline-rich transmembrane protein 1
|
affects expression
|
ISO
|
lead acetate affects the expression of PRRT1 protein
|
CTD |
PMID:36539177 |
|
NCBI chr17:34,848,396...34,852,108
Ensembl chr17:34,848,507...34,852,100
|
|
| G
|
Prss12
|
serine protease 12 neurotrypsin (motopsin)
|
increases expression
|
ISO
|
lead acetate results in increased expression of PRSS12 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:123,240,562...123,300,251
Ensembl chr 3:123,240,562...123,300,246
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|
| G
|
Prss2
|
serine protease 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of PRSS2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 6:41,498,710...41,502,013
Ensembl chr 6:41,498,721...41,502,013
|
|
| G
|
Prss8
|
serine protease 8 (prostasin)
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PRSS8 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:127,524,889...127,529,266
Ensembl chr 7:127,524,888...127,529,276
|
|
| G
|
Psma8
|
proteasome subunit alpha 8
|
increases expression
|
EXP
|
lead acetate results in increased expression of PSMA8 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr18:14,839,192...14,895,358
Ensembl chr18:14,839,208...14,895,358
|
|
| G
|
Psmb7
|
proteasome (prosome, macropain) subunit, beta type 7
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PSMB7 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:38,478,058...38,533,964
Ensembl chr 2:38,478,048...38,534,099
|
|
| G
|
Psmb9
|
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PSMB9 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr17:34,401,006...34,406,347
Ensembl chr17:34,400,961...34,406,738
|
|
| G
|
Psmc6
|
proteasome (prosome, macropain) 26S subunit, ATPase, 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of PSMC6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr14:45,567,285...45,587,150
Ensembl chr14:45,567,245...45,587,162
|
|
| G
|
Psmd4
|
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of PSMD4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:94,939,999...94,949,880
Ensembl chr 3:94,940,005...94,949,925
|
|
| G
|
Psme2
|
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
|
increases expression
|
EXP
|
lead acetate results in increased expression of PSME2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr14:55,824,897...55,828,558
Ensembl chr14:55,824,898...55,828,570
|
|
| G
|
Psors1c2
|
psoriasis susceptibility 1 candidate 2 (human)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PSORS1C2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr17:35,842,462...35,845,544
Ensembl chr17:35,844,098...35,845,544
|
|
| G
|
Psph
|
phosphoserine phosphatase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PSPH mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 5:129,842,622...129,864,318
Ensembl chr 5:129,842,622...129,864,513 Ensembl chr 5:129,842,622...129,864,513
|
|
| G
|
Ptbp3
|
polypyrimidine tract binding protein 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of PTBP3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:59,471,868...59,549,288
Ensembl chr 4:59,471,868...59,549,364
|
|
| G
|
Ptchd3
|
patched domain containing 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PTCHD3 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr11:121,721,050...121,734,259
Ensembl chr11:121,721,073...121,734,249
|
|
| G
|
Ptges3
|
prostaglandin E synthase 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PTGES3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr10:127,894,851...127,913,123
Ensembl chr10:127,894,823...127,913,141
|
|
| G
|
Ptgfr
|
prostaglandin F receptor
|
increases expression
|
EXP
|
lead acetate results in increased expression of PTGFR mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:151,504,247...151,543,165
Ensembl chr 3:151,502,139...151,543,267
|
|
| G
|
Ptgr1
|
prostaglandin reductase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PTGR1 mRNA
|
CTD |
PMID:22839698 PMID:38568856 |
|
NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
|
|
| G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
increases expression multiple interactions decreases expression
|
ISO EXP
|
lead acetate results in increased expression of PTGS2 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; U 0126 inhibits the reaction [lead acetate results in increased expression of PTGS2 protein] lead acetate results in decreased expression of PTGS2 mRNA lead acetate results in increased expression of PTGS2 mRNA; lead acetate results in increased expression of PTGS2 protein 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; Ascorbic Acid inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; Quercetin inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of PTGS2 mRNA]
|
CTD |
PMID:16395254 PMID:22728154 PMID:24530660 PMID:25088297 PMID:25270620 PMID:33862172 PMID:37471654 PMID:38568856 More...
|
|
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
|
|
| G
|
Pth
|
parathyroid hormone
|
multiple interactions
|
ISO
|
[Ethanol co-treated with lead acetate] results in increased expression of PTH protein
|
CTD |
PMID:23376407 |
|
NCBI chr 7:112,984,783...112,987,879
Ensembl chr 7:112,984,787...112,987,777
|
|
| G
|
Pthlh
|
parathyroid hormone-like peptide
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of PTHLH protein
|
CTD |
PMID:23604592 |
|
NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681
|
|
| G
|
Ptms
|
parathymosin
|
increases expression
|
ISO
|
lead acetate results in increased expression of PTMS mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:124,890,638...124,894,909
Ensembl chr 6:124,890,644...124,897,066
|
|
| G
|
Ptp4a1
|
protein tyrosine phosphatase 4a1
|
multiple interactions decreases expression
|
ISO EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of PTP4A1 mRNA lead acetate results in decreased expression of PTP4A1 mRNA
|
CTD |
PMID:12634122 PMID:21829687 |
|
NCBI chr 1:30,979,384...30,988,838
Ensembl chr 1:30,979,383...30,988,390 Ensembl chr 1:30,979,383...30,988,390
|
|
| G
|
Ptp4a3
|
protein tyrosine phosphatase 4a3
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of PTP4A3 intron
|
CTD |
PMID:33445541 |
|
NCBI chr15:73,594,991...73,629,075
Ensembl chr15:73,594,994...73,630,615
|
|
| G
|
Ptpn12
|
protein tyrosine phosphatase, non-receptor type 12
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of PTPN12 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 5:21,191,643...21,261,009
Ensembl chr 5:21,191,643...21,260,909
|
|
| G
|
Ptpn14
|
protein tyrosine phosphatase, non-receptor type 14
|
increases expression
|
EXP
|
lead acetate results in increased expression of PTPN14 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 1:189,460,417...189,608,892
Ensembl chr 1:189,460,465...189,608,892
|
|
| G
|
Ptpn2
|
protein tyrosine phosphatase, non-receptor type 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PTPN2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665
|
|
| G
|
Ptpn21
|
protein tyrosine phosphatase, non-receptor type 21
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PTPN21 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr12:98,643,000...98,703,664
Ensembl chr12:98,643,000...98,703,664
|
|
| G
|
Ptpn23
|
protein tyrosine phosphatase, non-receptor type 23
|
increases expression
|
ISO
|
lead acetate results in increased expression of PTPN23 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:110,214,152...110,237,278
Ensembl chr 9:110,214,150...110,237,281
|
|
| G
|
Ptpn6
|
protein tyrosine phosphatase, non-receptor type 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of PTPN6 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:124,697,670...124,715,672
Ensembl chr 6:124,697,670...124,715,677
|
|
| G
|
Ptprcap
|
protein tyrosine phosphatase receptor type C polypeptide-associated protein
|
increases expression
|
EXP
|
lead acetate results in increased expression of PTPRCAP mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:4,204,645...4,206,709
Ensembl chr19:4,203,603...4,206,750
|
|
| G
|
Ptprn
|
protein tyrosine phosphatase receptor type N
|
increases expression
|
ISO
|
lead acetate results in increased expression of PTPRN mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 1:75,223,679...75,241,437
Ensembl chr 1:75,223,671...75,241,146
|
|
| G
|
Ptpro
|
protein tyrosine phosphatase receptor type O
|
decreases expression multiple interactions
|
EXP ISO
|
lead acetate results in decreased expression of PTPRO mRNA [lead acetate co-treated with zinc protoporphyrin] results in increased expression of PTPRO mRNA
|
CTD |
PMID:21829687 PMID:22839698 |
|
NCBI chr 6:137,229,189...137,440,251
Ensembl chr 6:137,229,317...137,440,231
|
|
| G
|
Pvalb
|
parvalbumin
|
multiple interactions decreases expression
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of PVALB protein; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PVALB protein] lead acetate results in decreased expression of PVALB mRNA
|
CTD |
PMID:31708536 PMID:33862172 |
|
NCBI chr15:78,075,312...78,090,600
Ensembl chr15:78,075,314...78,090,600
|
|
| G
|
Pxdc1
|
PX domain containing 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of PXDC1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:34,811,823...34,836,664
Ensembl chr13:34,811,817...34,837,469
|
|
| G
|
Pxylp1
|
2-phosphoxylose phosphatase 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of PXYLP1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:96,705,396...96,774,732
Ensembl chr 9:96,705,389...96,774,722
|
|
| G
|
Pygb
|
brain glycogen phosphorylase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PYGB mRNA; lead acetate results in decreased expression of PYGB protein
|
CTD |
PMID:28916327 |
|
NCBI chr 2:150,628,716...150,673,668
Ensembl chr 2:150,628,655...150,673,678
|
|
| G
|
Pygm
|
muscle glycogen phosphorylase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of PYGM protein
|
CTD |
PMID:28916327 |
|
NCBI chr19:6,434,438...6,448,494
Ensembl chr19:6,434,429...6,448,489
|
|
| G
|
Pyroxd2
|
pyridine nucleotide-disulphide oxidoreductase domain 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of PYROXD2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr19:42,714,296...42,741,261
Ensembl chr19:42,714,297...42,741,214
|
|
| G
|
Qars1
|
glutaminyl-tRNA synthetase 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of QARS1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 9:108,385,204...108,393,140
Ensembl chr 9:108,384,905...108,393,140
|
|
| G
|
Qtrt2
|
queuine tRNA-ribosyltransferase accessory subunit 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of QTRT2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:43,681,879...43,710,063
Ensembl chr16:43,681,770...43,747,172
|
|
| G
|
Rab11fip2
|
RAB11 family interacting protein 2 (class I)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RAB11FIP2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr19:59,881,934...59,933,086
Ensembl chr19:59,891,316...59,932,086
|
|
| G
|
Rab14
|
RAB14, member RAS oncogene family
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RAB14 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:35,070,217...35,091,132
Ensembl chr 2:35,070,217...35,091,132
|
|
| G
|
Rab17
|
RAB17, member RAS oncogene family
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RAB17 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:90,885,855...90,897,395
Ensembl chr 1:90,885,855...90,897,383
|
|
| G
|
Rab2b
|
RAB2B, member RAS oncogene family
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RAB2B mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr14:52,499,216...52,516,852
Ensembl chr14:52,499,216...52,517,002
|
|
| G
|
Rab34
|
RAB34, member RAS oncogene family
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RAB34 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:78,079,253...78,083,019
Ensembl chr11:78,079,256...78,083,019
|
|
| G
|
Rab5if
|
RAB5 interacting factor
|
increases expression
|
ISO
|
lead acetate results in increased expression of RAB5IF mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:156,705,042...156,715,483
Ensembl chr 2:156,705,048...156,715,483
|
|
| G
|
Rab7b
|
RAB7B, member RAS oncogene family
|
increases expression
|
ISO
|
lead acetate results in increased expression of RAB7B mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:131,616,412...131,646,288
Ensembl chr 1:131,616,433...131,643,177
|
|
| G
|
Rabl6
|
RAB, member RAS oncogene family-like 6
|
increases expression
|
ISO
|
lead acetate results in increased expression of RABL6 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:25,473,029...25,498,493
Ensembl chr 2:25,473,030...25,498,533
|
|
| G
|
Rac1
|
Rac family small GTPase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of RAC1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791
|
|
| G
|
Rad17
|
RAD17 checkpoint clamp loader component
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of RAD17 protein
|
CTD |
PMID:38072110 |
|
NCBI chr13:100,753,672...100,787,569
Ensembl chr13:100,753,672...100,787,559
|
|
| G
|
Rad51b
|
RAD51 paralog B
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RAD51B mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr12:79,344,032...79,895,034
Ensembl chr12:79,344,056...79,861,464
|
|
| G
|
Raf1
|
v-raf-leukemia viral oncogene 1
|
increases phosphorylation multiple interactions
|
ISO
|
lead acetate results in increased phosphorylation of RAF1 protein 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased phosphorylation of RAF1 protein]; HRAS mutant form inhibits the reaction [lead acetate results in increased phosphorylation of RAF1 protein]; SU 6656 inhibits the reaction [lead acetate results in increased phosphorylation of RAF1 protein]
|
CTD |
PMID:19133285 |
|
NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
|
|
| G
|
Rag1
|
recombination activating 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RAG1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:101,468,597...101,479,877
Ensembl chr 2:101,468,627...101,479,846
|
|
| G
|
Rag2
|
recombination activating gene 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of RAG2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 2:101,455,057...101,462,873
Ensembl chr 2:101,455,063...101,462,874
|
|
| G
|
Ralgapa1
|
Ral GTPase activating protein, alpha subunit 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of RALGAPA1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr12:55,649,673...55,868,522
Ensembl chr12:55,649,681...55,867,952
|
|
| G
|
Rap2a
|
RAS related protein 2a
|
decreases methylation
|
ISO
|
lead acetate results in decreased methylation of RAP2A gene
|
CTD |
PMID:29571894 |
|
NCBI chr14:120,715,873...120,744,606
Ensembl chr14:120,715,856...120,744,606
|
|
| G
|
Rap2c
|
RAP2C, member of RAS oncogene family
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of RAP2C mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr X:50,093,163...50,108,966
Ensembl chr X:50,092,789...50,106,895
|
|
| G
|
Rapgefl1
|
Rap guanine nucleotide exchange factor (GEF)-like 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of RAPGEFL1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:98,727,611...98,744,519
Ensembl chr11:98,727,611...98,744,523
|
|
| G
|
Raph1
|
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of RAPH1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:60,509,997...60,606,233
Ensembl chr 1:60,521,451...60,606,263
|
|
| G
|
Rara
|
retinoic acid receptor, alpha
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RARA mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768
|
|
| G
|
Rars1
|
arginyl-tRNA synthetase 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RARS1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr11:35,699,207...35,725,355
Ensembl chr11:35,699,208...35,725,333
|
|
| G
|
Rasl11b
|
RAS-like, family 11, member B
|
increases expression
|
ISO
|
lead acetate results in increased expression of RASL11B mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 5:74,355,987...74,360,138
Ensembl chr 5:74,355,947...74,360,142
|
|
| G
|
Rax
|
retina and anterior neural fold homeobox
|
increases expression
|
EXP
|
lead acetate results in increased expression of RAX mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr18:66,067,710...66,072,160
Ensembl chr18:66,061,348...66,072,858
|
|
| G
|
Rb1
|
RB transcriptional corepressor 1
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of RB1 protein]; [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of RB1 protein; Wortmannin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of RB1 protein]
|
CTD |
PMID:18353414 |
|
NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
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|
| G
|
Rbbp4
|
retinoblastoma binding protein 4, chromatin remodeling factor
|
multiple interactions decreases expression
|
ISO
|
pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in decreased expression of RBBP4 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in decreased expression of RBBP4 protein]; RBBP4 protein inhibits the reaction [lead acetate results in decreased expression of BIRC5 mRNA]; RBBP4 protein inhibits the reaction [lead acetate results in decreased expression of BIRC5 protein] lead acetate results in decreased expression of RBBP4 mRNA; lead acetate results in decreased expression of RBBP4 protein
|
CTD |
PMID:37866543 |
|
NCBI chr 4:129,200,893...129,229,163
Ensembl chr 4:129,200,893...129,229,163
|
|
| G
|
Rbfox1
|
RNA binding protein, fox-1 homolog (C. elegans) 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which affects the methylation of RBFOX1 intron
|
CTD |
PMID:33445541 |
|
NCBI chr16:5,702,566...7,230,344
Ensembl chr16:5,124,665...7,229,391
|
|
| G
|
Rbfox3
|
RNA binding protein, fox-1 homolog (C. elegans) 3
|
increases expression decreases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of RBFOX3 mRNA lead acetate results in decreased expression of RBFOX3 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of RBFOX3 protein; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of RBFOX3 protein]
|
CTD |
PMID:25496477 PMID:33862172 PMID:33978298 |
|
NCBI chr11:118,380,586...118,802,423
Ensembl chr11:118,380,588...118,802,423
|
|
| G
|
Rbm24
|
RNA binding motif protein 24
|
increases expression
|
EXP
|
lead acetate results in increased expression of RBM24 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr13:46,571,664...46,584,575
Ensembl chr13:46,571,910...46,584,571
|
|
| G
|
Rbm3
|
RNA binding motif (RNP1, RRM) protein 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of RBM3 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr X:8,005,214...8,012,119
Ensembl chr X:8,005,214...8,012,119
|
|
| G
|
Rbm4
|
RNA binding motif protein 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of RBM4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:4,834,321...4,844,037
Ensembl chr19:4,834,321...4,843,929
|
|
| G
|
Rbp3
|
retinol binding protein 3, interstitial
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RBP3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:33,675,960...33,686,176
Ensembl chr14:33,675,960...33,686,173
|
|
| G
|
Rbpj
|
recombination signal binding protein for immunoglobulin kappa J region
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of RBPJ gene
|
CTD |
PMID:29571894 |
|
NCBI chr 5:53,713,121...53,814,787
Ensembl chr 5:53,623,494...53,814,704
|
|
| G
|
Rbsn
|
rabenosyn, RAB effector
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RBSN mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:92,163,693...92,191,874
Ensembl chr 6:92,163,693...92,191,906
|
|
| G
|
Rcor2
|
REST corepressor 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RCOR2 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr19:7,244,759...7,252,590
Ensembl chr19:7,244,690...7,252,590
|
|
| G
|
Rcvrn
|
recoverin
|
increases expression
|
EXP
|
lead acetate results in increased expression of RCVRN mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:67,586,152...67,594,181
Ensembl chr11:67,586,152...67,594,159
|
|
| G
|
Rdh13
|
retinol dehydrogenase 13 (all-trans and 9-cis)
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of RDH13 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 7:4,428,664...4,474,279
Ensembl chr 7:4,427,769...4,448,648
|
|
| G
|
Rdh9
|
retinol dehydrogenase 9
|
increases expression
|
EXP
|
lead acetate results in increased expression of RDH9 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr10:127,612,274...127,628,566
Ensembl chr10:127,612,255...127,628,566
|
|
| G
|
Recql4
|
RecQ protein-like 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of RECQL4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:76,587,753...76,594,820
Ensembl chr15:76,587,753...76,594,748
|
|
| G
|
Reg1
|
regenerating islet-derived 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of REG1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:78,402,966...78,405,651
Ensembl chr 6:78,399,694...78,405,650
|
|
| G
|
Reg2
|
regenerating islet-derived 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of REG2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:78,382,138...78,385,082
Ensembl chr 6:78,372,606...78,385,089
|
|
| G
|
Rel
|
reticuloendotheliosis oncogene
|
increases expression
|
EXP
|
lead acetate results in increased expression of REL mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr11:23,686,847...23,720,969
Ensembl chr11:23,686,847...23,720,970
|
|
| G
|
Rela
|
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
|
multiple interactions increases expression affects localization decreases expression
|
EXP ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of RELA protein]; 3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in increased expression of RELA protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased expression of RELA protein]; [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased phosphorylation of RELA protein; [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of RELA protein; [Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of RELA protein]; lead acetate results in increased phosphorylation of and results in increased expression of RELA protein; pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in increased expression of RELA protein]; U 0126 inhibits the reaction [lead acetate results in increased expression of RELA protein] lead acetate results in increased expression of RELA mRNA; lead acetate results in increased expression of RELA protein lead acetate affects the localization of RELA protein Ascorbic Acid inhibits the reaction [lead acetate affects the localization of RELA protein]; Proanthocyanidins inhibits the reaction [lead acetate affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in increased expression of RELA protein]; Quercetin inhibits the reaction [lead acetate affects the localization of RELA protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of RELA protein] lead acetate results in decreased expression of RELA mRNA
|
CTD |
PMID:22728154 PMID:24260418 PMID:24530660 PMID:25088297 PMID:36539177 PMID:37385299 PMID:37866543 PMID:38180308 PMID:38530053 More...
|
|
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
|
|
| G
|
Relb
|
avian reticuloendotheliosis viral (v-rel) oncogene related B
|
affects expression
|
EXP
|
lead acetate affects the expression of RELB mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363
|
|
| G
|
Reln
|
reelin
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of RELN mRNA lead acetate results in decreased expression of RELN mRNA
|
CTD |
PMID:24260418 PMID:33862172 |
|
NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700
|
|
| G
|
Rerg
|
RAS-like, estrogen-regulated, growth-inhibitor
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RERG mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:137,031,822...137,147,494
Ensembl chr 6:137,031,823...137,147,495
|
|
| G
|
Rest
|
RE1-silencing transcription factor
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of REST mRNA; lead acetate results in increased expression of REST protein [lead acetate results in increased abundance of Lead] which results in increased expression of REST protein; REST protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of HAP1 mRNA]; REST protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of HAP1 protein] REST protein promotes the reaction [lead acetate results in decreased expression of SV2C mRNA]; REST protein promotes the reaction [lead acetate results in decreased expression of SV2C protein]
|
CTD |
PMID:29505838 PMID:30742882 |
|
NCBI chr 5:77,413,273...77,434,279
Ensembl chr 5:77,413,338...77,434,279
|
|
| G
|
Ret
|
ret proto-oncogene
|
multiple interactions increases expression
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of RET mRNA lead acetate results in increased expression of RET mRNA
|
CTD |
PMID:12634122 PMID:22641619 |
|
NCBI chr 6:118,128,709...118,174,705
Ensembl chr 6:118,128,706...118,174,679
|
|
| G
|
Retnlb
|
resistin like beta
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RETNLB mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:48,637,219...48,639,255
Ensembl chr16:48,637,219...48,639,255
|
|
| G
|
Retreg1
|
reticulophagy regulator 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of RETREG1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr15:25,840,795...25,973,782
Ensembl chr15:25,843,266...25,973,773
|
|
| G
|
Retsat
|
retinol saturase (all trans retinol 13,14 reductase)
|
increases expression
|
ISO
|
lead acetate results in increased expression of RETSAT mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:72,575,585...72,584,471
Ensembl chr 6:72,575,458...72,585,408
|
|
| G
|
Rfx1
|
regulatory factor X, 1 (influences HLA class II expression)
|
increases expression
|
EXP
|
lead acetate results in increased expression of RFX1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:84,789,787...84,823,630
Ensembl chr 8:84,793,463...84,823,621
|
|
| G
|
Rgcc
|
regulator of cell cycle
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of RGCC mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr14:79,526,190...79,539,075
Ensembl chr14:79,526,196...79,539,085
|
|
| G
|
Rgs13
|
regulator of G-protein signaling 13
|
affects expression
|
ISO
|
lead acetate affects the expression of RGS13 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:144,013,083...144,053,240
Ensembl chr 1:144,014,392...144,053,110
|
|
| G
|
Rgs16
|
regulator of G-protein signaling 16
|
increases expression
|
ISO
|
lead acetate results in increased expression of RGS16 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 1:153,616,099...153,621,212
Ensembl chr 1:153,616,095...153,621,214
|
|
| G
|
Rgs18
|
regulator of G-protein signaling 18
|
affects expression
|
ISO
|
lead acetate affects the expression of RGS18 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 1:144,628,430...144,651,165
Ensembl chr 1:144,628,421...144,651,173
|
|
| G
|
Rgs19
|
regulator of G-protein signaling 19
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RGS19 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:181,330,212...181,336,330
Ensembl chr 2:181,330,212...181,335,770
|
|
| G
|
Rgs22
|
regulator of G-protein signalling 22
|
affects expression increases expression
|
ISO
|
lead acetate affects the expression of RGS22 mRNA lead acetate results in increased expression of RGS22 mRNA
|
CTD |
PMID:21864555 PMID:22641619 |
|
NCBI chr15:35,960,664...36,140,718
Ensembl chr15:36,009,625...36,140,546
|
|
| G
|
Rhbdd2
|
rhomboid domain containing 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RHBDD2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:135,661,508...135,675,230
Ensembl chr 5:135,661,472...135,675,302
|
|
| G
|
Rhebl1
|
Ras homolog enriched in brain like 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of RHEBL1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr15:98,775,659...98,779,424
Ensembl chr15:98,775,659...98,792,421
|
|
| G
|
Rho
|
rhodopsin
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of RHO mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of RHO protein
|
CTD |
PMID:28050121 |
|
NCBI chr 6:115,903,741...115,916,999
Ensembl chr 6:115,908,709...115,916,997
|
|
| G
|
Rhov
|
ras homolog family member V
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RHOV mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:119,099,682...119,108,489
Ensembl chr 2:119,099,682...119,101,753
|
|
| G
|
Rhox9
|
reproductive homeobox 9
|
increases expression
|
EXP
|
lead acetate results in increased expression of RHOX9 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr X:36,987,974...36,990,647
Ensembl chr X:36,987,974...36,990,647
|
|
| G
|
Rims1
|
regulating synaptic membrane exocytosis 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RIMS1 mRNA
|
CTD |
PMID:22160880 |
|
NCBI chr 1:22,356,196...22,845,239
Ensembl chr 1:22,356,475...22,845,203
|
|
| G
|
Ring1
|
ring finger protein 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of RING1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:34,239,766...34,243,654
Ensembl chr17:34,239,766...34,243,654
|
|
| G
|
Riok3
|
RIO kinase 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of RIOK3 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr18:12,259,114...12,290,424
Ensembl chr18:12,261,798...12,290,444
|
|
| G
|
Ripk4
|
receptor-interacting serine-threonine kinase 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RIPK4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr16:97,543,133...97,564,979
Ensembl chr16:97,543,133...97,564,987
|
|
| G
|
Ripor1
|
RHO family interacting cell polarization regulator 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of RIPOR1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:106,320,588...106,348,851
Ensembl chr 8:106,331,887...106,348,851
|
|
| G
|
Ripor2
|
RHO family interacting cell polarization regulator 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RIPOR2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:24,685,513...24,917,789
Ensembl chr13:24,685,508...24,917,799
|
|
| G
|
Rit1
|
Ras-like without CAAX 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of RIT1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:88,624,154...88,638,354
Ensembl chr 3:88,624,145...88,638,356
|
|
| G
|
Rnase1
|
ribonuclease, RNase A family, 1 (pancreatic)
|
increases expression
|
EXP
|
lead acetate results in increased expression of RNASE1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr14:51,382,459...51,384,224
Ensembl chr14:51,382,455...51,384,242
|
|
| G
|
Rnase4
|
ribonuclease, RNase A family 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of RNASE4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr14:51,328,534...51,343,608
Ensembl chr14:51,328,534...51,343,608
|
|
| G
|
Rnaseh2c
|
ribonuclease H2, subunit C
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RNASEH2C mRNA
|
CTD |
PMID:21829687 PMID:25270620 |
|
NCBI chr19:5,651,901...5,652,987
Ensembl chr19:5,651,901...5,657,047
|
|
| G
|
Rnasel
|
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
|
increases expression
|
ISO
|
lead acetate results in increased expression of RNASEL mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:153,625,089...153,644,441
Ensembl chr 1:153,625,172...153,639,967
|
|
| G
|
Rnf115
|
ring finger protein 115
|
increases expression
|
EXP
|
lead acetate results in increased expression of RNF115 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 3:96,634,869...96,698,471
Ensembl chr 3:96,634,980...96,698,954
|
|
| G
|
Rnf13
|
ring finger protein 13
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of RNF13 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 3:57,643,468...57,742,846
Ensembl chr 3:57,643,483...57,742,654
|
|
| G
|
Rnf138
|
ring finger protein 138
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of RNF138 mRNA [sodium arsenite co-treated with lead acetate] results in decreased expression of RNF138 protein
|
CTD |
PMID:20542052 PMID:38072110 |
|
NCBI chr18:21,134,202...21,161,281
Ensembl chr18:21,134,398...21,161,281
|
|
| G
|
Rnf145
|
ring finger protein 145
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RNF145 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr11:44,409,486...44,456,347
Ensembl chr11:44,409,791...44,456,347
|
|
| G
|
Rnf38
|
ring finger protein 38
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RNF38 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 4:44,126,210...44,233,929
Ensembl chr 4:44,126,210...44,233,789
|
|
| G
|
Rnh1
|
ribonuclease/angiogenin inhibitor 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of RNH1 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 7:140,740,239...140,752,764
Ensembl chr 7:140,740,239...140,752,770
|
|
| G
|
Robo2
|
roundabout guidance receptor 2
|
affects expression
|
ISO
|
lead acetate affects the expression of ROBO2 protein
|
CTD |
PMID:36539177 |
|
NCBI chr16:73,688,725...75,244,331
Ensembl chr16:73,688,727...75,244,270
|
|
| G
|
Rock1
|
Rho-associated coiled-coil containing protein kinase 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ROCK1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr18:10,064,401...10,182,225
Ensembl chr18:10,064,401...10,182,045
|
|
| G
|
Romo1
|
reactive oxygen species modulator 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of ROMO1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:155,986,073...155,987,714
Ensembl chr 2:155,985,959...155,987,717
|
|
| G
|
Ropn1l
|
ropporin 1-like
|
increases expression
|
EXP
|
lead acetate results in increased expression of ROPN1L mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:31,441,356...31,453,835
Ensembl chr15:31,441,357...31,453,883
|
|
| G
|
Rorc
|
RAR-related orphan receptor gamma
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RORC mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583
|
|
| G
|
Rpa3
|
replication protein A3
|
increases expression
|
ISO
|
lead acetate results in increased expression of RPA3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:8,255,936...8,259,141
Ensembl chr 6:8,255,936...8,259,173
|
|
| G
|
Rpe65
|
retinal pigment epithelium 65
|
increases expression
|
ISO
|
lead acetate results in increased expression of RPE65 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:159,304,712...159,330,944
Ensembl chr 3:159,304,812...159,330,958
|
|
| G
|
Rpgr
|
retinitis pigmentosa GTPase regulator
|
increases expression
|
ISO
|
lead acetate results in increased expression of RPGR mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr X:10,024,455...10,083,034
Ensembl chr X:9,939,860...10,083,159
|
|
| G
|
Rpl10l
|
ribosomal protein L10-like
|
increases expression
|
ISO
|
lead acetate results in increased expression of RPL10L mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr12:66,330,153...66,331,175
Ensembl chr12:66,330,153...66,331,175
|
|
| G
|
Rpl17
|
ribosomal protein L17
|
affects expression
|
ISO
|
lead acetate affects the expression of RPL17 protein
|
CTD |
PMID:36539177 |
|
NCBI chr18:75,132,049...75,136,455
Ensembl chr18:75,131,629...75,136,452
|
|
| G
|
Rpl22
|
ribosomal protein L22
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RPL22 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:152,408,893...152,418,539
Ensembl chr 4:152,410,199...152,418,528
|
|
| G
|
Rpl22l1
|
ribosomal protein L22 like 1
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of RPL22L1 mRNA lead acetate results in increased expression of RPL22L1 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr 3:28,859,660...28,861,573
Ensembl chr 3:28,859,585...28,861,573
|
|
| G
|
Rpl39l
|
ribosomal protein L39-like
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RPL39L mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:9,988,061...9,992,775
Ensembl chr16:9,988,090...9,992,775
|
|
| G
|
Rpl7a
|
ribosomal protein L7A
|
affects expression
|
ISO
|
lead acetate affects the expression of RPL7A protein
|
CTD |
PMID:36539177 |
|
NCBI chr 2:26,800,697...26,803,330
Ensembl chr 2:26,800,776...26,803,330
|
|
| G
|
Rpn1
|
ribophorin I
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RPN1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:88,061,455...88,082,286
Ensembl chr 6:88,061,464...88,082,286
|
|
| G
|
Rpp30
|
ribonuclease P/MRP 30 subunit
|
increases expression
|
EXP
|
lead acetate results in increased expression of RPP30 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:36,061,118...36,082,173
Ensembl chr19:36,061,116...36,082,177
|
|
| G
|
Rpp40
|
ribonuclease P 40 subunit
|
increases expression
|
EXP
|
lead acetate results in increased expression of RPP40 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr13:36,080,685...36,095,548
Ensembl chr13:36,077,455...36,090,342
|
|
| G
|
Rps10
|
ribosomal protein S10
|
increases expression
|
EXP
|
lead acetate results in increased expression of RPS10 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:27,849,389...27,854,218
Ensembl chr17:27,849,392...27,855,643
|
|
| G
|
Rps18
|
ribosomal protein S18
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RPS18 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr17:34,170,972...34,174,639
Ensembl chr17:34,170,973...34,174,975
|
|
| G
|
Rps19
|
ribosomal protein S19
|
increases expression
|
EXP
|
lead acetate results in increased expression of RPS19 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:24,584,013...24,589,236
Ensembl chr 7:24,583,796...24,589,231
|
|
| G
|
Rps6ka4
|
ribosomal protein S6 kinase, polypeptide 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of RPS6KA4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:6,806,573...6,819,513
Ensembl chr19:6,806,578...6,818,004
|
|
| G
|
Rps6kb1
|
ribosomal protein S6 kinase, polypeptide 1
|
decreases phosphorylation
|
ISO
|
lead acetate results in decreased phosphorylation of RPS6KB1 protein
|
CTD |
PMID:22811615 PMID:32879255 |
|
NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631
|
|
| G
|
Rptor
|
regulatory associated protein of MTOR, complex 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of RPTOR protein; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of RPTOR protein]
|
CTD |
PMID:31874198 |
|
NCBI chr11:119,493,731...119,790,417
Ensembl chr11:119,493,731...119,790,402
|
|
| G
|
Rrad
|
Ras-related associated with diabetes
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RRAD mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:105,354,702...105,357,921
Ensembl chr 8:105,354,702...105,357,959
|
|
| G
|
Rrs1
|
ribosome biogenesis regulator 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of RRS1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:9,615,633...9,617,680
Ensembl chr 1:9,615,633...9,617,680
|
|
| G
|
Rs1
|
retinoschisis (X-linked, juvenile) 1 (human)
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RS1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr X:159,548,815...159,584,800
Ensembl chr X:159,551,009...159,582,659
|
|
| G
|
Rsph10b
|
radial spoke head 10 homolog B (Chlamydomonas)
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of RSPH10B2 mRNA
|
CTD |
PMID:22839698 |
|
Ensembl chr 5:143,869,853...143,922,537
|
|
| G
|
Rsph4a
|
radial spoke head 4 homolog A (Chlamydomonas)
|
affects expression
|
ISO
|
lead acetate affects the expression of RSPH4A mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr10:33,781,107...33,792,017
Ensembl chr10:33,781,107...33,792,017
|
|
| G
|
Rspo3
|
R-spondin 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RSPO3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr10:29,329,102...29,411,863
Ensembl chr10:29,328,412...29,411,863
|
|
| G
|
Rsrp1
|
arginine/serine rich protein 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RSRP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:134,650,936...134,654,681
Ensembl chr 4:134,650,903...134,654,982
|
|
| G
|
Rtl6
|
retrotransposon Gag like 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of RTL6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr15:84,437,599...84,442,024
Ensembl chr15:84,437,599...84,442,024
|
|
| G
|
Rtn4
|
reticulon 4
|
affects expression increases expression
|
ISO
|
lead acetate affects the expression of RTN4 mRNA lead acetate results in increased expression of RTN4 mRNA
|
CTD |
PMID:21864555 PMID:38568856 |
|
NCBI chr11:29,642,898...29,694,414
Ensembl chr11:29,642,947...29,694,331
|
|
| G
|
Rundc3b
|
RUN domain containing 3B
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of RUNDC3B mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:8,540,336...8,673,079
Ensembl chr 5:8,540,334...8,672,952
|
|
| G
|
Runx1
|
runt related transcription factor 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of RUNX1 mRNA
|
CTD |
PMID:20542052 PMID:21829687 |
|
NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037
|
|
| G
|
Rusc2
|
RUN and SH3 domain containing 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of RUSC2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:43,377,202...43,427,088
Ensembl chr 4:43,381,979...43,427,088
|
|
| G
|
Rwdd4a
|
RWD domain containing 4A
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RWDD4A mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 8:47,986,680...48,005,872
Ensembl chr 8:47,986,699...48,005,990
|
|
| G
|
Rxrg
|
retinoid X receptor gamma
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of RXRG mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:167,425,902...167,467,191
Ensembl chr 1:167,425,953...167,467,192
|
|
| G
|
Ryr3
|
ryanodine receptor 3
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of RYR3 protein
|
CTD |
PMID:30905827 |
|
NCBI chr 2:112,461,699...113,047,755
Ensembl chr 2:112,461,700...113,047,441
|
|
| G
|
S100a10
|
S100 calcium binding protein A10 (calpactin)
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of S100A10 mRNA lead acetate results in decreased expression of S100A10 mRNA
|
CTD |
PMID:20542052 PMID:36539177 |
|
NCBI chr 3:93,462,424...93,471,952
Ensembl chr 3:93,462,387...93,471,950
|
|
| G
|
S100a11
|
S100 calcium binding protein A11
|
increases expression
|
ISO
|
lead acetate results in increased expression of S100A11 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:93,427,803...93,433,595
Ensembl chr 3:93,427,795...93,433,594
|
|
| G
|
S100a2
|
S100 calcium binding protein A2
|
increases expression
|
ISO
|
lead acetate results in increased expression of S100A2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:90,497,554...90,498,815
Ensembl chr 3:90,467,670...90,498,838
|
|
| G
|
S100a4
|
S100 calcium binding protein A4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of S100A4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:90,511,077...90,513,349
Ensembl chr 3:90,511,078...90,513,352
|
|
| G
|
S100a8
|
S100 calcium binding protein A8 (calgranulin A)
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of S100A8 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342
|
|
| G
|
S100a9
|
S100 calcium binding protein A9 (calgranulin B)
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of S100A9 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
|
|
| G
|
S100b
|
S100 protein, beta polypeptide, neural
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of S100B protein lead acetate results in increased expression of S100B protein
|
CTD |
PMID:17047031 PMID:38072110 |
|
NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993
|
|
| G
|
S1pr1
|
sphingosine-1-phosphate receptor 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of S1PR1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:115,504,082...115,508,704
Ensembl chr 3:115,504,082...115,508,721
|
|
| G
|
Saa1
|
serum amyloid A 1
|
decreases expression increases expression
|
ISO EXP
|
lead acetate results in decreased expression of SAA1 mRNA lead acetate results in increased expression of SAA1 mRNA
|
CTD |
PMID:22609695 PMID:38568856 |
|
NCBI chr 7:46,389,921...46,392,404
Ensembl chr 7:46,389,921...46,392,404
|
|
| G
|
Saa2
|
serum amyloid A 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SAA2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:46,401,257...46,403,737
Ensembl chr 7:46,401,214...46,403,737
|
|
| G
|
Sall4
|
spalt like transcription factor 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of SALL4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:168,590,252...168,609,121
Ensembl chr 2:168,590,252...168,609,863
|
|
| G
|
Sapcd2
|
suppressor APC domain containing 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of SAPCD2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:25,261,974...25,268,225
Ensembl chr 2:25,262,333...25,268,225
|
|
| G
|
Sart1
|
squamous cell carcinoma antigen recognized by T cells 1
|
affects expression increases expression
|
ISO
|
lead acetate affects the expression of SART1 protein lead acetate results in increased expression of SART1 mRNA
|
CTD |
PMID:36539177 PMID:38568856 |
|
NCBI chr19:5,427,551...5,438,731
Ensembl chr19:5,427,551...5,438,731
|
|
| G
|
Sat1
|
spermidine/spermine N1-acetyl transferase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of SAT1 mRNA
|
CTD |
PMID:11578147 PMID:38568856 |
|
NCBI chr X:153,996,128...153,999,345
Ensembl chr X:153,996,128...153,999,445
|
|
| G
|
Sbk1
|
SH3-binding kinase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of SBK1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:125,847,524...125,894,188
Ensembl chr 7:125,848,034...125,894,188
|
|
| G
|
Sbno2
|
strawberry notch 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of SBNO2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr10:79,892,826...79,941,942
Ensembl chr10:79,892,826...79,941,405
|
|
| G
|
Sbsn
|
suprabasin
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SBSN mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:30,432,099...30,455,559
Ensembl chr 7:30,450,896...30,455,559
|
|
| G
|
Scaf1
|
SR-related CTD-associated factor 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of SCAF1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:44,652,372...44,665,537
Ensembl chr 7:44,652,372...44,665,787
|
|
| G
|
Scaf11
|
SR-related CTD-associated factor 11
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SCAF11 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr15:96,309,580...96,358,695
Ensembl chr15:96,309,580...96,358,724
|
|
| G
|
Scamp1
|
secretory carrier membrane protein 1
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SCAMP1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr13:94,337,818...94,422,339
Ensembl chr13:94,337,818...94,422,365
|
|
| G
|
Scand1
|
SCAN domain-containing 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SCAND1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:156,153,766...156,154,624
Ensembl chr 2:156,153,766...156,154,667
|
|
| G
|
Scarb1
|
scavenger receptor class B, member 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of SCARB1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
|
|
| G
|
Scarf2
|
scavenger receptor class F, member 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SCARF2 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr16:17,615,146...17,626,158
Ensembl chr16:17,615,146...17,626,157
|
|
| G
|
Scd1
|
stearoyl-Coenzyme A desaturase 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of SCD1 mRNA
|
CTD |
PMID:30623991 |
|
NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
|
|
| G
|
Scd2
|
stearoyl-Coenzyme A desaturase 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of SCD protein
|
CTD |
PMID:38072110 |
|
NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303
|
|
| G
|
Scgb1c1
|
secretoglobin, family 1C, member 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SCGB1C1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:140,425,478...140,426,682
Ensembl chr 7:140,425,460...140,426,682
|
|
| G
|
Scgb2b27
|
secretoglobin, family 2B, member 27
|
increases expression
|
EXP
|
lead acetate results in increased expression of SCGB2B27 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:33,711,344...33,713,367
Ensembl chr 7:33,711,346...33,713,367
|
|
| G
|
Schip1
|
schwannomin interacting protein 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of SCHIP1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 3:67,972,135...68,533,815
Ensembl chr 3:67,972,135...68,533,814
|
|
| G
|
Scn7a
|
sodium channel, voltage-gated, type VII, alpha
|
increases expression
|
ISO
|
lead acetate results in increased expression of SCN7A mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:66,503,770...66,615,254
Ensembl chr 2:66,503,769...66,615,258
|
|
| G
|
Scnn1a
|
sodium channel, nonvoltage-gated 1 alpha
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SCNN1A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:125,286,657...125,321,906
Ensembl chr 6:125,297,622...125,321,906
|
|
| G
|
Scnn1b
|
sodium channel, nonvoltage-gated 1 beta
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SCNN1B mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:121,464,261...121,517,951
Ensembl chr 7:121,464,261...121,517,737
|
|
| G
|
Scnn1g
|
sodium channel, nonvoltage-gated 1 gamma
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SCNN1G mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:121,333,643...121,367,705
Ensembl chr 7:121,333,702...121,367,698
|
|
| G
|
Scrn3
|
secernin 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of SCRN3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:73,142,980...73,168,158
Ensembl chr 2:73,142,945...73,168,162
|
|
| G
|
Sct
|
secretin
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SCT mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:140,858,243...140,859,082
Ensembl chr 7:140,858,243...140,859,046
|
|
| G
|
Sdc1
|
syndecan 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of SDC1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:8,821,396...8,843,716
Ensembl chr12:8,821,323...8,843,715
|
|
| G
|
Sdcbp2
|
syndecan binding protein (syntenin) 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of SDCBP2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:151,414,203...151,431,925
Ensembl chr 2:151,414,542...151,431,925
|
|
| G
|
Sdccag8
|
serologically defined colon cancer antigen 8
|
increases expression
|
EXP
|
lead acetate results in increased expression of SDCCAG8 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:176,642,226...176,848,004
Ensembl chr 1:176,642,226...176,848,003
|
|
| G
|
Sdf2l1
|
stromal cell-derived factor 2-like 1
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of SDF2L1 mRNA lead acetate results in increased expression of SDF2L1 mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr16:16,948,002...16,950,247
Ensembl chr16:16,948,002...16,950,247
|
|
| G
|
Sdhb
|
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
|
multiple interactions decreases expression
|
ISO EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of SDHB protein; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SDHB protein] lead acetate results in decreased expression of SDHB mRNA
|
CTD |
PMID:21829687 PMID:36096218 |
|
NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504
|
|
| G
|
Sdr16c5
|
short chain dehydrogenase/reductase family 16C, member 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SDR16C5 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:3,995,942...4,019,663
Ensembl chr 4:3,995,936...4,019,663
|
|
| G
|
Sec14l5
|
SEC14-like lipid binding 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of SEC14L5 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr16:4,964,758...5,005,135
Ensembl chr16:4,964,973...5,005,135
|
|
| G
|
Sec23b
|
SEC23 homolog B, COPII coat complex component
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SEC23B mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 2:144,398,165...144,432,673
Ensembl chr 2:144,398,149...144,432,669
|
|
| G
|
Sec24d
|
SEC24 homolog D, COPII coat complex component
|
increases expression
|
ISO
|
lead acetate results in increased expression of SEC24D mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:123,058,451...123,159,290
Ensembl chr 3:123,061,104...123,159,290
|
|
| G
|
Sec61g
|
SEC61 translocon subunit gamma
|
increases expression
|
ISO
|
lead acetate results in increased expression of SEC61G mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:16,451,638...16,458,484
Ensembl chr11:16,450,530...16,458,484
|
|
| G
|
Sel1l
|
sel-1 suppressor of lin-12-like (C. elegans)
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SEL1L mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr12:91,772,817...91,815,931
Ensembl chr12:91,772,817...91,815,931
|
|
| G
|
Sel1l3
|
sel-1 suppressor of lin-12-like 3 (C. elegans)
|
increases expression
|
ISO
|
lead acetate results in increased expression of SEL1L3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:53,264,425...53,370,794
Ensembl chr 5:53,264,425...53,371,269
|
|
| G
|
Selenbp1
|
selenium binding protein 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SELENBP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:94,840,394...94,852,069
Ensembl chr 3:94,840,367...94,852,069
|
|
| G
|
Selenop
|
selenoprotein P
|
increases expression
|
ISO
|
lead acetate results in increased expression of SELENOP protein
|
CTD |
PMID:25975991 |
|
NCBI chr15:3,300,249...3,309,992
Ensembl chr15:3,298,029...3,309,990
|
|
| G
|
Selp
|
selectin, platelet
|
increases expression
|
EXP
|
lead acetate results in increased expression of SELP mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595
|
|
| G
|
Sema3e
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
|
increases expression
|
EXP
|
lead acetate results in increased expression of SEMA3E mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 5:14,075,290...14,306,703
Ensembl chr 5:14,075,290...14,306,703
|
|
| G
|
Sema6a
|
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SEMA6A mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr18:47,378,321...47,504,267
Ensembl chr18:47,368,665...47,501,937
|
|
| G
|
Senp6
|
SUMO/sentrin specific peptidase 6
|
increases expression
|
ISO
|
lead acetate results in increased expression of SENP6 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:79,973,862...80,052,064
Ensembl chr 9:79,974,185...80,052,235
|
|
| G
|
Septin12
|
septin 12
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased expression of SEPTIN12 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of SEPTIN12 protein
|
CTD |
PMID:32142724 |
|
NCBI chr16:4,804,722...4,815,716
Ensembl chr16:4,804,722...4,815,716
|
|
| G
|
Septin9
|
septin 9
|
increases expression
|
ISO
|
lead acetate results in increased expression of SEPTIN9 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:117,090,487...117,253,151
Ensembl chr11:117,090,487...117,253,151
|
|
| G
|
Serpinb1b
|
serine (or cysteine) peptidase inhibitor, clade B, member 1b
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SERPINB1B mRNA
|
CTD |
PMID:29746905 |
|
NCBI chr13:33,262,478...33,278,363
Ensembl chr13:33,262,558...33,278,363
|
|
| G
|
Serpinb2
|
serine (or cysteine) peptidase inhibitor, clade B, member 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of SERPINB2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:107,439,153...107,453,330
Ensembl chr 1:107,439,153...107,463,208
|
|
| G
|
Serpinb3a
|
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SERPINB4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:106,973,317...106,980,033
Ensembl chr 1:106,973,317...106,980,033
|
|
| G
|
Serpinb3b
|
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B
|
increases expression
|
EXP
|
lead acetate results in increased expression of SERPINB3B mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:107,081,691...107,088,844
Ensembl chr 1:107,081,670...107,206,091
|
|
| G
|
Serpinb3d
|
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SERPINB3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:107,005,893...107,011,210
Ensembl chr 1:107,005,897...107,011,236
|
|
| G
|
Serpine1
|
serine (or cysteine) peptidase inhibitor, clade E, member 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of SERPINE1 mRNA
|
CTD |
PMID:27562236 PMID:37939567 PMID:38568856 |
|
NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
|
|
| G
|
Serping1
|
serine (or cysteine) peptidase inhibitor, clade G, member 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of SERPING1 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 2:84,595,704...84,605,748
Ensembl chr 2:84,595,731...84,605,788
|
|
| G
|
Serpinh1
|
serine (or cysteine) peptidase inhibitor, clade H, member 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of SERPINH1 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446
|
|
| G
|
Setd7
|
SET domain containing (lysine methyltransferase) 7
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of SETD7 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 3:51,422,740...51,468,519
Ensembl chr 3:51,422,740...51,468,300
|
|
| G
|
Sf3a2
|
splicing factor 3a, subunit 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of SF3A2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:80,634,569...80,640,756
Ensembl chr10:80,634,032...80,640,758
|
|
| G
|
Sfn
|
stratifin
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of SFN mRNA lead acetate results in increased expression of SFN mRNA
|
CTD |
PMID:20680508 PMID:37939567 PMID:38568856 |
|
NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479
|
|
| G
|
Sfpq
|
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
|
increases expression
|
EXP
|
lead acetate results in increased expression of SFPQ mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:126,914,504...126,944,894
Ensembl chr 4:126,915,117...126,930,806
|
|
| G
|
Sfrp1
|
secreted frizzled-related protein 1
|
affects expression
|
ISO
|
lead acetate affects the expression of SFRP1 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 8:23,901,401...23,939,648
Ensembl chr 8:23,901,518...23,939,648
|
|
| G
|
Sfrp2
|
secreted frizzled-related protein 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SFRP2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 3:83,673,628...83,681,621
Ensembl chr 3:83,673,628...83,681,623
|
|
| G
|
Sftpb
|
surfactant associated protein B
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SFTPB mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:72,281,594...72,291,354
Ensembl chr 6:72,281,594...72,291,354
|
|
| G
|
Sftpc
|
surfactant associated protein C
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SFTPC mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr14:70,758,381...70,761,521
Ensembl chr14:70,758,389...70,761,521
|
|
| G
|
Sgk1
|
serum/glucocorticoid regulated kinase 1
|
increases expression multiple interactions decreases expression
|
ISO EXP
|
lead acetate results in increased expression of SGK1 mRNA [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SGK1 mRNA lead acetate results in decreased expression of SGK1 mRNA
|
CTD |
PMID:12634122 PMID:22641619 PMID:25270620 PMID:38568856 |
|
NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802
|
|
| G
|
Sgpp2
|
sphingosine-1-phosphate phosphatase 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SGPP2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:78,286,186...78,396,926
Ensembl chr 1:78,286,982...78,396,926
|
|
| G
|
Sh2d2a
|
SH2 domain containing 2A
|
increases expression
|
ISO
|
lead acetate results in increased expression of SH2D2A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:87,754,070...87,763,116
Ensembl chr 3:87,754,062...87,763,029
|
|
| G
|
Sh3bgrl3
|
SH3 domain binding glutamic acid-rich protein-like 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of SH3BGRL3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:133,854,717...133,856,044
Ensembl chr 4:133,854,717...133,856,100
|
|
| G
|
Sh3rf2
|
SH3 domain containing ring finger 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SH3RF2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr18:42,185,531...42,291,760
Ensembl chr18:42,186,732...42,292,025
|
|
| G
|
Shisa4
|
shisa family member 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of SHISA4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 1:135,298,578...135,302,812
Ensembl chr 1:135,298,795...135,302,975
|
|
| G
|
Shmt2
|
serine hydroxymethyltransferase 2 (mitochondrial)
|
increases expression
|
ISO EXP
|
lead acetate results in increased expression of SHMT2 mRNA
|
CTD |
PMID:11578147 PMID:25270620 |
|
NCBI chr10:127,352,992...127,358,313
Ensembl chr10:127,352,992...127,358,313
|
|
| G
|
Shroom1
|
shroom family member 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of SHROOM1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:53,347,904...53,358,593
Ensembl chr11:53,348,032...53,358,593
|
|
| G
|
Shroom3
|
shroom family member 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of SHROOM3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:92,831,294...93,113,618
Ensembl chr 5:92,831,294...93,113,177
|
|
| G
|
Siae
|
sialic acid acetylesterase
|
increases expression
|
EXP
|
lead acetate results in increased expression of SIAE mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:37,525,117...37,559,554
Ensembl chr 9:37,466,994...37,560,951
|
|
| G
|
Sidt1
|
SID1 transmembrane family, member 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of SIDT1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:44,060,540...44,153,575
Ensembl chr16:44,060,543...44,153,559
|
|
| G
|
Sik1
|
salt inducible kinase 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SIK1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr17:32,063,222...32,074,808
Ensembl chr17:32,063,224...32,074,778
|
|
| G
|
Sin3a
|
transcriptional regulator, SIN3A (yeast)
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SIN3A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:56,979,271...57,035,652
Ensembl chr 9:56,979,324...57,035,650
|
|
| G
|
Sirt1
|
sirtuin 1
|
multiple interactions decreases expression
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of SIRT1 mRNA; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 mRNA]; Resveratrol inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SIRT1 protein] lead acetate results in decreased expression of SIRT1 protein SRT1720 inhibits the reaction [lead acetate results in decreased expression of SIRT1 protein]
|
CTD |
PMID:33978298 PMID:34842334 PMID:39276841 |
|
NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
|
|
| G
|
Sirt3
|
sirtuin 3
|
increases expression multiple interactions
|
EXP
|
lead acetate results in increased expression of SIRT3 protein PPARGC1A protein affects the reaction [lead acetate results in increased expression of SIRT3 protein]
|
CTD |
PMID:27236077 |
|
NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222
|
|
| G
|
Skil
|
SKI-like
|
increases expression
|
ISO
|
lead acetate results in increased expression of SKIL mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 3:31,149,259...31,176,741
Ensembl chr 3:31,149,207...31,176,726
|
|
| G
|
Slamf1
|
signaling lymphocytic activation molecule family member 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLAMF1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 1:171,594,700...171,628,752
Ensembl chr 1:171,594,695...171,628,752
|
|
| G
|
Slc10a1
|
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLC10A1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479
|
|
| G
|
Slc11a2
|
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
|
decreases expression multiple interactions increases expression
|
ISO EXP
|
lead acetate results in decreased expression of SLC11A2 mRNA; lead acetate results in decreased expression of SLC11A2 protein [lead acetate results in increased abundance of Lead] which affects the expression of SLC11A2 protein lead acetate results in increased expression of SLC11A2 mRNA; lead acetate results in increased expression of SLC11A2 mRNA alternative form lead acetate results in increased expression of SLC11A2 mRNA; lead acetate results in increased expression of SLC11A2 protein
|
CTD |
PMID:23219683 PMID:30312686 PMID:34350654 |
|
NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953
|
|
| G
|
Slc12a2
|
solute carrier family 12, member 2
|
decreases expression increases expression
|
ISO EXP
|
lead acetate results in decreased expression of SLC12A2 mRNA lead acetate results in increased expression of SLC12A2 mRNA
|
CTD |
PMID:11578147 PMID:21829687 |
|
NCBI chr18:58,011,505...58,079,893
Ensembl chr18:58,011,750...58,079,893
|
|
| G
|
Slc12a8
|
solute carrier family 12 (potassium/chloride transporters), member 8
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC12A8 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr16:33,337,440...33,484,508
Ensembl chr16:33,337,698...33,484,505
|
|
| G
|
Slc13a3
|
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC13A3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:165,247,215...165,315,117
Ensembl chr 2:165,246,948...165,315,150
|
|
| G
|
Slc16a3
|
solute carrier family 16 (monocarboxylic acid transporters), member 3
|
multiple interactions increases expression
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased expression of SLC16A3 protein; [Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of SLC16A3 protein]; lead acetate results in decreased expression of and affects the localization of SLC16A3 protein lead acetate results in increased expression of SLC16A3 mRNA
|
CTD |
PMID:30615929 PMID:34508822 |
|
NCBI chr11:120,839,310...120,849,826
Ensembl chr11:120,839,306...120,851,694
|
|
| G
|
Slc16a5
|
solute carrier family 16 (monocarboxylic acid transporters), member 5
|
decreases expression
|
EXP ISO
|
lead acetate results in decreased expression of SLC16A5 mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr11:115,353,231...115,365,224
Ensembl chr11:115,353,300...115,365,224
|
|
| G
|
Slc17a3
|
solute carrier family 17 (sodium phosphate), member 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of SLC17A3 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr13:24,020,905...24,044,701
Ensembl chr13:24,023,417...24,044,699
|
|
| G
|
Slc17a6
|
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLC17A6 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:51,271,578...51,320,874
Ensembl chr 7:51,271,754...51,320,867
|
|
| G
|
Slc17a7
|
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
|
decreases expression increases expression
|
EXP
|
lead acetate results in decreased expression of SLC17A7 mRNA lead acetate results in increased expression of SLC17A7 mRNA
|
CTD |
PMID:24260418 |
|
NCBI chr 7:44,813,345...44,825,563
Ensembl chr 7:44,813,373...44,825,566
|
|
| G
|
Slc18a1
|
solute carrier family 18 (vesicular monoamine), member 1
|
decreases expression increases methylation
|
ISO
|
lead acetate results in decreased expression of SLC18A1 mRNA lead acetate results in increased methylation of SLC18A1 gene
|
CTD |
PMID:22641619 PMID:29571894 |
|
NCBI chr 8:69,490,360...69,547,951
Ensembl chr 8:69,490,363...69,541,887
|
|
| G
|
Slc18a2
|
solute carrier family 18 (vesicular monoamine), member 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLC18A2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444
|
|
| G
|
Slc18a3
|
solute carrier family 18 (vesicular monoamine), member 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC18A3 protein
|
CTD |
PMID:27492863 |
|
NCBI chr14:32,184,394...32,186,807
Ensembl chr14:32,184,395...32,186,807
|
|
| G
|
Slc19a3
|
solute carrier family 19, member 3
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC19A3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:82,990,242...83,016,541
Ensembl chr 1:82,990,244...83,016,169
|
|
| G
|
Slc1a1
|
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC1A1 mRNA; lead acetate results in increased expression of SLC1A1 protein
|
CTD |
PMID:15985313 |
|
NCBI chr19:28,812,535...28,891,360
Ensembl chr19:28,812,449...28,891,360
|
|
| G
|
Slc1a2
|
solute carrier family 1 (glial high affinity glutamate transporter), member 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC1A2 mRNA
|
CTD |
PMID:15985313 |
|
NCBI chr 2:102,488,584...102,621,129
Ensembl chr 2:102,489,004...102,621,129
|
|
| G
|
Slc1a3
|
solute carrier family 1 (glial high affinity glutamate transporter), member 3
|
affects expression increases expression
|
ISO
|
lead acetate affects the expression of SLC1A3 mRNA lead acetate results in increased expression of SLC1A3 mRNA
|
CTD |
PMID:11578147 PMID:15985313 |
|
NCBI chr15:8,663,608...8,742,648
Ensembl chr15:8,663,608...8,740,248
|
|
| G
|
Slc1a4
|
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of SLC1A4 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr11:20,252,180...20,282,713
Ensembl chr11:20,252,180...20,282,713
|
|
| G
|
Slc22a14
|
solute carrier family 22 (organic cation transporter), member 14
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC22A14 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 9:118,998,521...119,019,496
Ensembl chr 9:118,998,523...119,019,473
|
|
| G
|
Slc22a3
|
solute carrier family 22 (organic cation transporter), member 3
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC22A3 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591
|
|
| G
|
Slc22a4
|
solute carrier family 22 (organic cation transporter), member 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC22A4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:53,873,941...53,920,866
Ensembl chr11:53,873,949...53,918,916
|
|
| G
|
Slc25a16
|
solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC25A16 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr10:62,756,454...62,782,278
Ensembl chr10:62,756,412...62,782,277
|
|
| G
|
Slc25a23
|
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC25A23 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:57,350,711...57,366,863
Ensembl chr17:57,350,711...57,366,863
|
|
| G
|
Slc25a28
|
solute carrier family 25, member 28
|
increases expression
|
EXP
|
lead acetate results in increased expression of SLC25A28 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:43,652,240...43,663,320
Ensembl chr19:43,652,240...43,663,320
|
|
| G
|
Slc26a2
|
solute carrier family 26 (sulfate transporter), member 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC26A2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr18:61,329,926...61,344,668
Ensembl chr18:61,325,991...61,344,684
|
|
| G
|
Slc26a7
|
solute carrier family 26, member 7
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC26A7 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 4:14,502,430...14,621,946
Ensembl chr 4:14,502,430...14,621,805
|
|
| G
|
Slc27a2
|
solute carrier family 27 (fatty acid transporter), member 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC27A2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163
|
|
| G
|
Slc27a4
|
solute carrier family 27 (fatty acid transporter), member 4
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of SLC27A4 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 2:29,692,646...29,707,534
Ensembl chr 2:29,692,646...29,707,534
|
|
| G
|
Slc27a5
|
solute carrier family 27 (fatty acid transporter), member 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLC27A5 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:12,722,273...12,732,119
Ensembl chr 7:12,722,273...12,732,119
|
|
| G
|
Slc29a2
|
solute carrier family 29 (nucleoside transporters), member 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC29A2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:5,069,085...5,082,000
Ensembl chr19:5,073,888...5,082,000
|
|
| G
|
Slc2a1
|
solute carrier family 2 (facilitated glucose transporter), member 1
|
increases expression multiple interactions
|
ISO EXP
|
lead acetate results in increased expression of SLC2A1 mRNA; lead acetate results in increased expression of SLC2A1 protein [[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of SLC2A1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 protein; [Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 protein] [lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 protein; [sodium arsenite co-treated with lead acetate] results in decreased expression of SLC2A1 protein; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 mRNA]; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 protein]
|
CTD |
PMID:30980912 PMID:31874198 PMID:34508822 PMID:38072110 PMID:38157908 |
|
NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
|
|
| G
|
Slc2a10
|
solute carrier family 2 (facilitated glucose transporter), member 10
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC2A10 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:165,345,817...165,361,837
Ensembl chr 2:165,345,707...165,361,837
|
|
| G
|
Slc2a3
|
solute carrier family 2 (facilitated glucose transporter), member 3
|
increases methylation multiple interactions increases expression
|
ISO EXP
|
lead acetate results in increased methylation of SLC2A3 gene [lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A3 protein lead acetate results in increased expression of SLC2A3 mRNA; lead acetate results in increased expression of SLC2A3 protein [lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A3 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A3 protein; [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SLC2A3 mRNA; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A3 mRNA]; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A3 protein]
|
CTD |
PMID:12634122 PMID:29571894 PMID:30980912 PMID:31874198 PMID:34508822 |
|
NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599
|
|
| G
|
Slc2a5
|
solute carrier family 2 (facilitated glucose transporter), member 5
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC2A5 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 4:150,203,801...150,228,625
Ensembl chr 4:150,203,740...150,228,626
|
|
| G
|
Slc30a1
|
solute carrier family 30 (zinc transporter), member 1
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of SLC30A1 mRNA [sodium arsenite co-treated with lead acetate] results in increased expression of SLC30A1 protein
|
CTD |
PMID:25270620 PMID:38072110 |
|
NCBI chr 1:191,638,810...191,645,359
Ensembl chr 1:191,638,879...191,645,359
|
|
| G
|
Slc30a2
|
solute carrier family 30 (zinc transporter), member 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC30A2 protein
|
CTD |
PMID:24311739 |
|
NCBI chr 4:134,070,357...134,081,795
Ensembl chr 4:134,070,492...134,081,795
|
|
| G
|
Slc30a5
|
solute carrier family 30 (zinc transporter), member 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of SLC30A5 mRNA; lead acetate results in increased expression of SLC30A5 protein
|
CTD |
PMID:30623991 |
|
NCBI chr13:100,939,153...100,969,988
Ensembl chr13:100,939,156...100,969,935
|
|
| G
|
Slc30a6
|
solute carrier family 30 (zinc transporter), member 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of SLC30A6 mRNA
|
CTD |
PMID:30623991 |
|
NCBI chr17:74,702,573...74,731,225
Ensembl chr17:74,702,603...74,731,216
|
|
| G
|
Slc31a1
|
solute carrier family 31, member 1
|
multiple interactions increases expression
|
ISO EXP
|
lead acetate promotes the reaction [SLC31A1 protein results in increased uptake of Copper]; lead acetate results in increased expression of and affects the localization of SLC31A1 protein [[lead acetate results in increased abundance of Lead] co-treated with [cupric chloride results in increased abundance of Copper]] results in increased expression of SLC31A1 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of SLC31A1 protein lead acetate results in increased expression of SLC31A1 mRNA; lead acetate results in increased expression of SLC31A1 protein
|
CTD |
PMID:24316150 PMID:25579025 PMID:30623991 PMID:40010429 |
|
NCBI chr 4:62,278,821...62,310,006
Ensembl chr 4:62,278,964...62,310,006
|
|
| G
|
Slc32a1
|
solute carrier family 32 (GABA vesicular transporter), member 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC32A1 protein
|
CTD |
PMID:20375082 |
|
NCBI chr 2:158,449,158...158,457,667
Ensembl chr 2:158,452,687...158,457,668
|
|
| G
|
Slc35a5
|
solute carrier family 35, member A5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLC35A5 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:44,959,936...44,979,036
Ensembl chr16:44,959,936...44,979,069
|
|
| G
|
Slc35e1
|
solute carrier family 35, member E1
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SLC35E1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 8:73,231,839...73,246,473
Ensembl chr 8:73,234,485...73,246,458
|
|
| G
|
Slc35f2
|
solute carrier family 35, member F2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC35F2 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:53,678,733...53,725,445
Ensembl chr 9:53,678,822...53,725,438
|
|
| G
|
Slc37a2
|
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC37A2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:37,140,445...37,166,709
Ensembl chr 9:37,138,881...37,167,034
|
|
| G
|
Slc38a2
|
solute carrier family 38, member 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLC38A2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr15:96,585,267...96,597,609
Ensembl chr15:96,585,273...96,597,611
|
|
| G
|
Slc39a10
|
solute carrier family 39 (zinc transporter), member 10
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLC39A10 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 1:46,846,704...46,964,952
Ensembl chr 1:46,846,704...46,932,012
|
|
| G
|
Slc39a12
|
solute carrier family 39 (zinc transporter), member 12
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC39A12 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 2:14,345,476...14,499,787
Ensembl chr 2:14,393,127...14,499,788
|
|
| G
|
Slc39a14
|
solute carrier family 39 (zinc transporter), member 14
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of SLC39A14 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr14:70,540,916...70,588,873
Ensembl chr14:70,540,918...70,588,874
|
|
| G
|
Slc39a4
|
solute carrier family 39 (zinc transporter), member 4
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC39A4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr15:76,496,583...76,501,579
Ensembl chr15:76,496,583...76,501,584
|
|
| G
|
Slc39a5
|
solute carrier family 39 (metal ion transporter), member 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of SLC39A5 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr10:128,231,796...128,237,145
Ensembl chr10:128,231,800...128,237,098
|
|
| G
|
Slc39a8
|
solute carrier family 39 (metal ion transporter), member 8
|
decreases expression
|
ISO EXP
|
lead acetate results in decreased expression of SLC39A8 mRNA
|
CTD |
PMID:22613225 PMID:22641619 PMID:38568856 |
|
NCBI chr 3:135,522,644...135,594,333
Ensembl chr 3:135,531,040...135,594,333
|
|
| G
|
Slc3a2
|
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of SLC3A2 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of SLC3A2 mRNA
|
CTD |
PMID:25270620 PMID:38568856 PMID:39276841 |
|
NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733
|
|
| G
|
Slc40a1
|
solute carrier family 40 (iron-regulated transporter), member 1
|
decreases expression multiple interactions increases expression
|
ISO EXP
|
lead acetate results in decreased expression of SLC40A1 mRNA; lead acetate results in decreased expression of SLC40A1 protein [lead acetate results in increased abundance of Lead] which results in decreased expression of SLC40A1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SLC40A1 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of SLC40A1 mRNA lead acetate results in increased expression of SLC40A1 mRNA
|
CTD |
PMID:22613225 PMID:23219683 PMID:30623991 PMID:36642386 PMID:39276841 |
|
NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683
|
|
| G
|
Slc48a1
|
solute carrier family 48 (heme transporter), member 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC48A1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:97,682,246...97,690,573
Ensembl chr15:97,676,401...97,690,573
|
|
| G
|
Slc4a1
|
solute carrier family 4 (anion exchanger), member 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC4A1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr11:102,239,646...102,256,107
Ensembl chr11:102,239,650...102,257,029
|
|
| G
|
Slc4a11
|
solute carrier family 4, sodium bicarbonate transporter-like, member 11
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLC4A11 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:130,526,027...130,539,439
Ensembl chr 2:130,526,033...130,539,439
|
|
| G
|
Slc4a5
|
solute carrier family 4, sodium bicarbonate cotransporter, member 5
|
affects expression
|
ISO
|
lead acetate affects the expression of SLC4A5 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 6:83,184,561...83,281,927
Ensembl chr 6:83,196,810...83,281,927
|
|
| G
|
Slc4a7
|
solute carrier family 4, sodium bicarbonate cotransporter, member 7
|
increases expression decreases expression
|
ISO
|
lead acetate results in increased expression of SLC4A7 mRNA lead acetate results in decreased expression of SLC4A7 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr14:7,669,819...7,766,808
Ensembl chr14:7,669,823...7,767,484
|
|
| G
|
Slc5a11
|
solute carrier family 5 (sodium/glucose cotransporter), member 11
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLC5A11 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:122,813,817...122,873,612
Ensembl chr 7:122,814,003...122,872,476
|
|
| G
|
Slc5a5
|
solute carrier family 5 (sodium iodide symporter), member 5
|
affects expression
|
ISO
|
lead acetate affects the expression of SLC5A5 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 8:71,335,529...71,345,429
Ensembl chr 8:71,335,533...71,345,401
|
|
| G
|
Slc5a7
|
solute carrier family 5 (choline transporter), member 7
|
affects expression
|
ISO
|
lead acetate affects the expression of SLC5A7 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr17:54,580,618...54,606,071
Ensembl chr17:54,580,618...54,606,062
|
|
| G
|
Slc5a8
|
solute carrier family 5 (iodide transporter), member 8
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLC5A8 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr10:88,721,854...88,765,377
Ensembl chr10:88,721,854...88,765,377
|
|
| G
|
Slc6a1
|
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC6A1 protein; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC6A1 protein]
|
CTD |
PMID:31708536 |
|
NCBI chr 6:114,259,735...114,294,491
Ensembl chr 6:114,259,596...114,294,493
|
|
| G
|
Slc6a11
|
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLC6A11 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 6:114,108,202...114,226,847
Ensembl chr 6:114,108,202...114,226,913
|
|
| G
|
Slc6a2
|
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
|
affects expression
|
ISO
|
lead acetate affects the expression of SLC6A2 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295
|
|
| G
|
Slc6a5
|
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of SLC6A5 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 7:49,556,733...49,613,612
Ensembl chr 7:49,559,894...49,613,604
|
|
| G
|
Slc6a6
|
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
|
decreases expression increases expression
|
ISO
|
lead acetate results in decreased expression of SLC6A6 mRNA lead acetate results in increased expression of SLC6A6 mRNA
|
CTD |
PMID:11578147 PMID:38568856 |
|
NCBI chr 6:91,661,031...91,736,044
Ensembl chr 6:91,661,034...91,736,047
|
|
| G
|
Slc6a8
|
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC6A8 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr X:72,716,739...72,726,108
Ensembl chr X:72,716,756...72,726,108
|
|
| G
|
Slc6a9
|
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC6A9 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 4:117,692,240...117,726,502
Ensembl chr 4:117,691,703...117,732,395
|
|
| G
|
Slc7a1
|
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of SLC7A1 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 5:148,264,220...148,336,714
Ensembl chr 5:148,264,220...148,336,714
|
|
| G
|
Slc7a10
|
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
|
increases expression
|
EXP
|
lead acetate results in increased expression of SLC7A10 protein
|
CTD |
PMID:25242007 |
|
NCBI chr 7:34,885,520...34,900,539
Ensembl chr 7:34,885,810...34,900,539
|
|
| G
|
Slc7a11
|
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
|
increases expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of SLC7A11 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of SLC7A11 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SLC7A11 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of SLC7A11 mRNA; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC7A11 protein]; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of SLC7A11 mRNA]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC7A11 protein]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of SLC7A11 mRNA] [sodium arsenite co-treated with lead acetate] results in increased expression of SLC7A11 protein
|
CTD |
PMID:22839698 PMID:25270620 PMID:27562236 PMID:36642386 PMID:37939567 PMID:38072110 PMID:38568856 PMID:39276841 More...
|
|
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
|
|
| G
|
Slc7a8
|
solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLC7A8 mRNA
|
CTD |
PMID:27562236 |
|
NCBI chr14:54,959,672...55,019,343
Ensembl chr14:54,959,666...55,019,403
|
|
| G
|
Slco1a1
|
solute carrier organic anion transporter family, member 1a1
|
increases expression
|
EXP
|
lead acetate results in increased expression of SLCO1A1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:141,853,007...141,892,688
Ensembl chr 6:141,853,008...141,892,688
|
|
| G
|
Slco1a5
|
solute carrier organic anion transporter family, member 1a5
|
decreases expression affects expression
|
ISO
|
lead acetate results in decreased expression of SLCO1A5 mRNA lead acetate affects the expression of SLCO1A5 mRNA
|
CTD |
PMID:21864555 PMID:22641619 |
|
NCBI chr 6:142,179,953...142,268,707
Ensembl chr 6:142,179,953...142,268,707
|
|
| G
|
Slco1b2
|
solute carrier organic anion transporter family, member 1b2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SLCO1B2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372
|
|
| G
|
Slco2a1
|
solute carrier organic anion transporter family, member 2a1
|
increases expression decreases expression
|
ISO
|
lead acetate results in increased expression of SLCO2A1 mRNA lead acetate results in decreased expression of SLCO2A1 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr 9:102,885,686...102,973,201
Ensembl chr 9:102,865,911...102,973,201
|
|
| G
|
Slco4a1
|
solute carrier organic anion transporter family, member 4a1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLCO4A1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:180,098,019...180,116,646
Ensembl chr 2:180,098,038...180,116,660
|
|
| G
|
Slfn5
|
schlafen 5
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SLFN5 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr11:82,842,175...82,855,681
Ensembl chr11:82,842,175...82,855,666
|
|
| G
|
Slitrk6
|
SLIT and NTRK-like family, member 6
|
increases expression
|
ISO
|
lead acetate results in increased expression of SLITRK6 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr14:110,984,770...110,992,640
Ensembl chr14:110,986,012...110,992,581
|
|
| G
|
Smad1
|
SMAD family member 1
|
multiple interactions
|
EXP
|
lead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD1 protein]
|
CTD |
PMID:17805416 |
|
NCBI chr 8:80,065,024...80,126,057
Ensembl chr 8:80,065,024...80,126,147
|
|
| G
|
Smad3
|
SMAD family member 3
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of SMAD3 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276
|
|
| G
|
Smad5
|
SMAD family member 5
|
multiple interactions increases methylation
|
EXP ISO
|
lead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD5 protein] lead acetate results in increased methylation of SMAD5 gene
|
CTD |
PMID:17805416 PMID:29571894 |
|
NCBI chr13:56,850,804...56,890,191
Ensembl chr13:56,850,823...56,890,190
|
|
| G
|
Smad9
|
SMAD family member 9
|
multiple interactions
|
EXP
|
lead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD9 protein]
|
CTD |
PMID:17805416 |
|
NCBI chr 3:54,662,873...54,709,162
Ensembl chr 3:54,663,003...54,708,678
|
|
| G
|
Smarca2
|
SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of SMARCA2 protein
|
CTD |
PMID:38072110 |
|
NCBI chr19:26,582,578...26,755,721
Ensembl chr19:26,582,450...26,755,722
|
|
| G
|
Smarca4
|
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of SMARCA4 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 9:21,527,377...21,615,526
Ensembl chr 9:21,527,465...21,615,526
|
|
| G
|
Smarcad1
|
SNF2 related chromatin remodeling ATPase with DExD box 1
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of SMARCAD1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 6:65,019,577...65,093,045
Ensembl chr 6:65,019,567...65,093,045
|
|
| G
|
Smarcd2
|
SWI/SNF related BAF chromatin remodeling complex subunit D2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SMARCD2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:106,153,997...106,163,810
Ensembl chr11:106,154,005...106,163,798
|
|
| G
|
Smc1b
|
structural maintenance of chromosomes 1B
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SMC1B mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:84,948,890...85,016,158
Ensembl chr15:84,948,890...85,016,165
|
|
| G
|
Smc3
|
structural maintenance of chromosomes 3
|
affects expression
|
ISO
|
lead acetate affects the expression of SMC3 protein
|
CTD |
PMID:36539177 |
|
NCBI chr19:53,588,827...53,634,262
Ensembl chr19:53,588,829...53,634,264
|
|
| G
|
Smcr8
|
Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SMCR8 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr11:60,668,351...60,679,113
Ensembl chr11:60,668,350...60,679,113
|
|
| G
|
Smim11
|
small integral membrane protein 11
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SMIM11 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr16:92,098,131...92,109,929
Ensembl chr16:92,098,174...92,109,929
|
|
| G
|
Smox
|
spermine oxidase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SMOX mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:131,333,624...131,367,103
Ensembl chr 2:131,333,416...131,367,842
|
|
| G
|
Smpd1
|
sphingomyelin phosphodiesterase 1, acid lysosomal
|
increases activity multiple interactions
|
EXP
|
lead acetate results in increased activity of SMPD1 protein [S-allylcysteine co-treated with Clotrimazole] inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]; Clotrimazole inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]; S-allylcysteine inhibits the reaction [lead acetate results in increased activity of SMPD1 protein]
|
CTD |
PMID:22033380 |
|
NCBI chr 7:105,203,567...105,207,596
Ensembl chr 7:105,203,567...105,207,596
|
|
| G
|
Smpdl3a
|
sphingomyelin phosphodiesterase, acid-like 3A
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SMPDL3A mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr10:57,670,640...57,687,926
Ensembl chr10:57,670,431...57,687,926
|
|
| G
|
Smpdl3b
|
sphingomyelin phosphodiesterase, acid-like 3B
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SMPDL3B mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:132,460,277...132,484,558
Ensembl chr 4:132,460,277...132,484,563
|
|
| G
|
Smtn
|
smoothelin
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of SMTN mRNA lead acetate results in increased expression of SMTN mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr11:3,467,522...3,489,337
Ensembl chr11:3,467,521...3,490,612
|
|
| G
|
Smtnl2
|
smoothelin-like 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SMTNL2 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr11:72,279,989...72,302,539
Ensembl chr11:72,279,990...72,302,539
|
|
| G
|
Smyd5
|
SET and MYND domain containing 5
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of SMYD5 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 6:85,408,958...85,423,411
Ensembl chr 6:85,408,971...85,423,417
|
|
| G
|
Snai1
|
snail family zinc finger 1
|
multiple interactions
|
ISO
|
CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of SNAI1 mRNA]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of SNAI1 protein]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of SNAI1 mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of SNAI1 protein]
|
CTD |
PMID:39722890 |
|
NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734
|
|
| G
|
Snai2
|
snail family zinc finger 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of SNAI2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249
|
|
| G
|
Snap25
|
synaptosomal-associated protein 25
|
decreases expression
|
EXP ISO
|
lead acetate results in decreased expression of SNAP25 mRNA; lead acetate results in decreased expression of SNAP25 protein
|
CTD |
PMID:21126476 PMID:27492863 PMID:27984133 |
|
NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348
|
|
| G
|
Snap29
|
synaptosomal-associated protein 29
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of SNAP29 gene
|
CTD |
PMID:29571894 |
|
NCBI chr16:17,223,864...17,248,690
Ensembl chr16:17,223,850...17,248,691
|
|
| G
|
Snca
|
synuclein, alpha
|
increases expression
|
ISO
|
lead acetate results in increased expression of SNCA protein
|
CTD |
PMID:22811615 |
|
NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
|
|
| G
|
Sncaip
|
synuclein, alpha interacting protein (synphilin)
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SNCAIP mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr18:52,900,872...53,049,007
Ensembl chr18:52,900,781...53,049,007
|
|
| G
|
Snd1
|
staphylococcal nuclease and tudor domain containing 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of SND1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:28,480,332...28,935,161
Ensembl chr 6:28,475,138...28,935,161
|
|
| G
|
Snhg7
|
small nucleolar RNA host gene 7
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SNHG7 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:26,527,188...26,530,256
Ensembl chr 2:26,526,613...26,530,577
|
|
| G
|
Snrnp70
|
small nuclear ribonucleoprotein 70 (U1)
|
increases expression
|
ISO
|
lead acetate results in increased expression of SNRNP70 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:45,025,878...45,045,177
Ensembl chr 7:45,025,877...45,045,166
|
|
| G
|
Snrpf
|
small nuclear ribonucleoprotein polypeptide F
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SNRPF mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr10:93,418,891...93,425,520
Ensembl chr10:93,418,891...93,425,568
|
|
| G
|
Sntb2
|
syntrophin, basic 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of SNTB2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 8:107,662,372...107,740,864
Ensembl chr 8:107,662,382...107,746,346
|
|
| G
|
Sntg2
|
syntrophin, gamma 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of SNTG2 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr12:30,224,481...30,423,424
Ensembl chr12:30,224,481...30,423,374
|
|
| G
|
Snx10
|
sorting nexin 10
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SNX10 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:51,500,882...51,567,659
Ensembl chr 6:51,500,881...51,567,659
|
|
| G
|
Snx4
|
sorting nexin 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of SNX4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr16:33,071,826...33,119,932
Ensembl chr16:33,071,812...33,120,639
|
|
| G
|
Snx6
|
sorting nexin 6
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of SNX6 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SNX6 protein
|
CTD |
PMID:30738087 |
|
NCBI chr12:54,793,124...54,842,464
Ensembl chr12:54,793,134...54,842,488
|
|
| G
|
Sod1
|
superoxide dismutase 1, soluble
|
multiple interactions decreases activity decreases expression increases expression increases activity
|
ISO EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of SOD1 mRNA; [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SOD1 mRNA; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA] lead acetate results in decreased activity of SOD1 protein 3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in decreased activity of SOD1 protein]; [cupric chloride results in increased abundance of Copper] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased activity of SOD1 protein]; [lead acetate results in increased abundance of Lead] inhibits the reaction [[cupric chloride results in increased abundance of Copper] which results in increased activity of SOD1 protein]; [lead acetate results in increased abundance of Lead] which results in decreased activity of SOD1 protein; [lead acetate results in increased abundance of Lead] which results in increased activity of SOD1 protein; [Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of SOD1 protein]; Acetylcysteine inhibits the reaction [[cupric chloride results in increased abundance of Copper] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased activity of SOD1 protein]]; Acetylcysteine inhibits the reaction [[lead acetate results in increased abundance of Lead] inhibits the reaction [[cupric chloride results in increased abundance of Copper] which results in increased activity of SOD1 protein]]; mitoquinone inhibits the reaction [[cupric chloride results in increased abundance of Copper] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased activity of SOD1 protein]]; mitoquinone inhibits the reaction [[lead acetate results in increased abundance of Lead] inhibits the reaction [[cupric chloride results in increased abundance of Copper] which results in increased activity of SOD1 protein]]; tetrathiomolybdate inhibits the reaction [[cupric chloride results in increased abundance of Copper] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased activity of SOD1 protein]]; tetrathiomolybdate inhibits the reaction [[lead acetate results in increased abundance of Lead] inhibits the reaction [[cupric chloride results in increased abundance of Copper] which results in increased activity of SOD1 protein]] lead acetate results in decreased expression of SOD1 mRNA [Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of SOD1 protein]; lead acetate promotes the reaction [sodium arsenite results in decreased activity of SOD1 protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate promotes the reaction [sodium arsenite results in decreased activity of SOD1 protein]]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate results in decreased activity of SOD1 protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite promotes the reaction [lead acetate results in decreased activity of SOD1 protein]]; sinapinic acid inhibits the reaction [lead acetate results in decreased expression of SOD1 protein]; sodium arsenite promotes the reaction [lead acetate results in decreased activity of SOD1 protein] lead acetate results in increased expression of SOD1 mRNA; lead acetate results in increased expression of SOD1 protein lead acetate results in decreased expression of SOD1 mRNA; lead acetate results in decreased expression of SOD1 protein lead acetate results in increased activity of SOD1 protein
|
CTD |
PMID:12634122 PMID:15014207 PMID:15569323 PMID:20680508 PMID:22534743 PMID:23906897 PMID:24530660 PMID:29746905 PMID:30623991 PMID:31610155 PMID:34508822 PMID:37325564 PMID:37385299 PMID:38530053 PMID:40010429 More...
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|
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
|
|
| G
|
Sod2
|
superoxide dismutase 2, mitochondrial
|
decreases activity multiple interactions decreases expression increases expression
|
ISO EXP
|
lead acetate results in decreased activity of SOD2 protein [cupric chloride results in increased abundance of Copper] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased activity of SOD2 protein]; [lead acetate results in increased abundance of Lead] inhibits the reaction [[cupric chloride results in increased abundance of Copper] which results in increased activity of SOD2 protein]; [lead acetate results in increased abundance of Lead] which results in increased activity of SOD2 protein; Acetylcysteine inhibits the reaction [[cupric chloride results in increased abundance of Copper] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased activity of SOD2 protein]]; Acetylcysteine inhibits the reaction [[lead acetate results in increased abundance of Lead] inhibits the reaction [[cupric chloride results in increased abundance of Copper] which results in increased activity of SOD2 protein]]; mitoquinone inhibits the reaction [[cupric chloride results in increased abundance of Copper] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased activity of SOD2 protein]]; mitoquinone inhibits the reaction [[lead acetate results in increased abundance of Lead] inhibits the reaction [[cupric chloride results in increased abundance of Copper] which results in increased activity of SOD2 protein]]; tetrathiomolybdate inhibits the reaction [[cupric chloride results in increased abundance of Copper] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased activity of SOD2 protein]]; tetrathiomolybdate inhibits the reaction [[lead acetate results in increased abundance of Lead] inhibits the reaction [[cupric chloride results in increased abundance of Copper] which results in increased activity of SOD2 protein]] lead acetate results in decreased expression of SOD2 mRNA lead acetate results in increased expression of SOD2 mRNA lead acetate results in decreased expression of SOD2 mRNA; lead acetate results in decreased expression of SOD2 protein 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in decreased expression of SOD2 mRNA]; [Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of SOD2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of SOD2 mRNA]; Genistein inhibits the reaction [lead acetate results in decreased expression of SOD2 protein]; lead acetate promotes the reaction [sodium arsenite results in decreased activity of SOD2 protein]; lead acetate results in decreased expression of and results in decreased activity of SOD2 protein; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate promotes the reaction [sodium arsenite results in decreased activity of SOD2 protein]]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [lead acetate results in decreased activity of SOD2 protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite promotes the reaction [lead acetate results in decreased activity of SOD2 protein]]; sodium arsenite promotes the reaction [lead acetate results in decreased activity of SOD2 protein] [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SOD2 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SOD2 mRNA; Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD2 mRNA]; Rosmarinic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD2 mRNA]
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CTD |
PMID:22197700 PMID:22534743 PMID:22839698 PMID:23906897 PMID:26797587 PMID:31610155 PMID:32116774 PMID:32208856 PMID:33862172 PMID:38568856 PMID:40010429 More...
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NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
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Sod3
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superoxide dismutase 3, extracellular
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affects expression increases expression
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ISO EXP
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lead acetate affects the expression of SOD3 mRNA lead acetate results in increased expression of SOD3 mRNA
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CTD |
PMID:21864555 PMID:29746905 |
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NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760
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| G
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Sorcs2
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sortilin-related VPS10 domain containing receptor 2
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multiple interactions
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EXP
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[lead acetate results in increased abundance of Lead] which results in increased methylation of SORCS2 intron
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CTD |
PMID:33445541 |
|
NCBI chr 5:36,174,524...36,555,541
Ensembl chr 5:36,174,524...36,555,483
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| G
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Sord
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sorbitol dehydrogenase
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increases expression
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ISO
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lead acetate results in increased expression of SORD mRNA
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CTD |
PMID:11578147 |
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NCBI chr 2:122,065,320...122,095,818
Ensembl chr 2:122,065,230...122,095,821
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| G
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Sostdc1
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sclerostin domain containing 1
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decreases expression
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EXP
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lead acetate results in decreased expression of SOSTDC1 mRNA
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CTD |
PMID:22609695 |
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NCBI chr12:36,364,168...36,368,451
Ensembl chr12:36,364,138...36,368,451
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| G
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Sowahc
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sosondowah ankyrin repeat domain family member C
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increases expression
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EXP
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lead acetate results in increased expression of SOWAHC mRNA
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CTD |
PMID:21829687 |
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NCBI chr10:59,057,744...59,062,256
Ensembl chr10:59,057,775...59,062,256
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| G
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Sox18
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SRY (sex determining region Y)-box 18
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decreases expression
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ISO
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lead acetate results in decreased expression of SOX18 mRNA
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CTD |
PMID:22641619 |
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NCBI chr 2:181,311,630...181,313,433
Ensembl chr 2:181,311,629...181,313,433
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| G
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Sox2
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SRY (sex determining region Y)-box 2
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increases expression decreases expression multiple interactions
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EXP ISO
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lead acetate results in increased expression of SOX2 mRNA lead acetate results in decreased expression of SOX2 mRNA sodium arsenite promotes the reaction [lead acetate results in decreased expression of SOX2 mRNA]
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CTD |
PMID:31715224 PMID:38072110 |
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NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610
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| G
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Sox3
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SRY (sex determining region Y)-box 3
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affects expression
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EXP
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lead acetate affects the expression of SOX3 mRNA
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CTD |
PMID:24260418 |
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NCBI chr X:59,934,972...59,937,045
Ensembl chr X:59,934,972...59,937,036
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| G
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Sox4
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SRY (sex determining region Y)-box 4
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decreases expression
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EXP
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lead acetate results in decreased expression of SOX4 mRNA
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CTD |
PMID:22613225 |
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NCBI chr13:29,132,902...29,137,682
Ensembl chr13:29,132,902...29,137,696
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| G
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Sox9
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SRY (sex determining region Y)-box 9
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multiple interactions increases expression
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EXP
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BMP2 promotes the reaction [lead acetate results in increased expression of SOX9 mRNA]; lead acetate promotes the reaction [BMP2 results in increased expression of SOX9 mRNA]
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CTD |
PMID:17805416 |
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NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586
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| G
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Sp1
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trans-acting transcription factor 1
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multiple interactions increases expression
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ISO EXP
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tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein] lead acetate results in increased expression of SP1 mRNA; lead acetate results in increased expression of SP1 protein
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CTD |
PMID:23867794 PMID:24260418 PMID:24462621 |
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NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839
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| G
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Sp100
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nuclear antigen Sp100
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decreases expression
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ISO
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lead acetate results in decreased expression of SP100 mRNA
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CTD |
PMID:22641619 |
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NCBI chr 1:85,577,683...85,637,719
Ensembl chr 1:85,577,709...85,637,719
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| G
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Sp110
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Sp110 nuclear body protein
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increases expression
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EXP
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lead acetate results in increased expression of SP110 mRNA
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CTD |
PMID:20542052 |
|
NCBI chr 1:85,498,462...85,538,571
Ensembl chr 1:85,504,620...85,526,538
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| G
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Sp2
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Sp2 transcription factor
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increases expression
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EXP
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lead acetate results in increased expression of SP2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:96,844,158...96,873,785
Ensembl chr11:96,844,167...96,873,785
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| G
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Sp7
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Sp7 transcription factor 7
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decreases expression
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EXP
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lead acetate results in decreased expression of SP7 mRNA
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CTD |
PMID:22613225 |
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NCBI chr15:102,265,038...102,275,498
Ensembl chr15:102,265,041...102,275,617
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| G
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Spa17
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sperm autoantigenic protein 17
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affects expression
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ISO
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lead acetate affects the expression of SPA17 mRNA
|
CTD |
PMID:21864555 |
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NCBI chr 9:37,514,590...37,525,018
Ensembl chr 9:37,514,586...37,525,018
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| G
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Spaca3
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sperm acrosome associated 3
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increases expression
|
EXP
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lead acetate results in increased expression of SPACA3 mRNA
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CTD |
PMID:20542052 |
|
NCBI chr11:80,749,189...80,758,640
Ensembl chr11:80,749,191...80,758,640
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| G
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Spag16
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sperm associated antigen 16
|
multiple interactions
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EXP
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[lead acetate results in increased abundance of Lead] which results in decreased methylation of SPAG16 intron
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CTD |
PMID:33445541 |
|
NCBI chr 1:69,866,031...70,764,291
Ensembl chr 1:69,866,129...70,764,291
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| G
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Spag17
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sperm associated antigen 17
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increases expression
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EXP
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lead acetate results in increased expression of SPAG17 mRNA
|
CTD |
PMID:20542052 |
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NCBI chr 3:99,792,653...100,050,638
Ensembl chr 3:99,792,722...100,050,638
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| G
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Sparcl1
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SPARC-like 1
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multiple interactions
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ISO
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[sodium arsenite co-treated with lead acetate] results in increased expression of SPARCL1 protein
|
CTD |
PMID:38072110 |
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NCBI chr 5:104,226,974...104,261,954
Ensembl chr 5:104,226,977...104,261,599
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| G
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Spata6
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spermatogenesis associated 6
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decreases expression multiple interactions
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ISO EXP
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lead acetate results in decreased expression of SPATA6 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of SPATA6 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SPATA6 protein
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CTD |
PMID:22641619 PMID:32142724 |
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NCBI chr 4:111,577,151...111,686,339
Ensembl chr 4:111,577,181...111,686,381
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| G
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Spatc1l
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spermatogenesis and centriole associated 1 like
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multiple interactions
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EXP
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[lead acetate results in increased abundance of Lead] which results in decreased expression of SPATC1L mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SPATC1L protein
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CTD |
PMID:32142724 |
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NCBI chr10:76,394,180...76,406,035
Ensembl chr10:76,398,106...76,406,035
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| G
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Spcs1
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signal peptidase complex subunit 1 homolog (S. cerevisiae)
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affects expression
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EXP
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lead acetate affects the expression of SPCS1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr14:30,721,783...30,723,330
Ensembl chr14:30,721,783...30,723,629
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| G
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Spcs2
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signal peptidase complex subunit 2 homolog (S. cerevisiae)
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decreases expression
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EXP
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lead acetate results in decreased expression of SPCS2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:99,486,775...99,512,576
Ensembl chr 7:99,486,776...99,512,669
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| G
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Spdl1
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spindle apparatus coiled-coil protein 1
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increases expression
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EXP
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lead acetate results in increased expression of SPDL1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:34,700,012...34,724,492
Ensembl chr11:34,700,017...34,724,468
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| G
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Spesp1
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sperm equatorial segment protein 1
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decreases expression
|
EXP
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lead acetate results in decreased expression of SPESP1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:62,178,011...62,189,461
Ensembl chr 9:62,178,011...62,189,490
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| G
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Spg21
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SPG21, maspardin
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increases expression
|
EXP
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lead acetate results in increased expression of SPG21 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 9:65,360,571...65,395,753
Ensembl chr 9:65,368,229...65,395,752
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| G
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Sphk1
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sphingosine kinase 1
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increases expression
|
ISO
|
lead acetate results in increased expression of SPHK1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:116,421,662...116,427,502
Ensembl chr11:116,421,751...116,427,501
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| G
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Spink1
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serine peptidase inhibitor, Kazal type 1
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multiple interactions
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ISO
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[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SPINK1 mRNA
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CTD |
PMID:12634122 |
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NCBI chr18:43,861,134...43,870,302
Ensembl chr18:43,861,147...43,870,622
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| G
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Spink2
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serine peptidase inhibitor, Kazal type 2
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increases expression
|
EXP
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lead acetate results in increased expression of SPINK2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:77,352,953...77,364,106
Ensembl chr 5:77,352,954...77,359,318
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| G
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Spink4
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serine peptidase inhibitor, Kazal type 4
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decreases expression
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ISO
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lead acetate results in decreased expression of SPINK4 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 4:40,920,056...40,931,395
Ensembl chr 4:40,920,052...40,931,395
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| G
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Spocd1
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SPOC domain containing 1
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increases expression
|
ISO
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lead acetate results in increased expression of SPOCD1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:129,822,560...129,850,908
Ensembl chr 4:129,823,042...129,850,908
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| G
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Spp1
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secreted phosphoprotein 1
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increases expression multiple interactions
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ISO EXP
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lead acetate results in increased expression of SPP1 mRNA lead acetate results in increased expression of and results in increased secretion of SPP1 protein; NFE2L2 protein affects the reaction [lead acetate results in increased expression of SPP1 mRNA]
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CTD |
PMID:27562236 PMID:30312686 PMID:37939567 PMID:38568856 |
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NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
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| G
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Sprn
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shadow of prion protein
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decreases expression
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ISO
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lead acetate results in decreased expression of SPRN mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:139,730,541...139,734,572
Ensembl chr 7:139,730,541...139,734,790
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| G
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Sprr1b
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small proline-rich protein 1B
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increases expression
|
EXP
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lead acetate results in increased expression of SPRR1B mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 3:92,344,115...92,346,124
Ensembl chr 3:92,344,116...92,346,096
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| G
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Spry2
|
sprouty RTK signaling antagonist 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SPRY2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr14:106,129,381...106,134,559
Ensembl chr14:106,129,381...106,134,253
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| G
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Spry4
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sprouty RTK signaling antagonist 4
|
increases expression
|
ISO
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lead acetate results in increased expression of SPRY4 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr18:38,719,300...38,734,400
Ensembl chr18:38,719,300...38,734,468
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| G
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Spryd7
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SPRY domain containing 7
|
increases expression
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ISO
|
lead acetate results in increased expression of SPRYD7 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:61,769,300...61,794,335
Ensembl chr14:61,769,442...61,794,335
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| G
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Spsb1
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splA/ryanodine receptor domain and SOCS box containing 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SPSB1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:149,980,740...150,039,494
Ensembl chr 4:149,980,740...150,039,500
|
|
| G
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Sptbn1
|
spectrin beta, non-erythrocytic 1
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of SPTBN1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr11:30,049,395...30,218,384
Ensembl chr11:30,049,395...30,218,175
|
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| G
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Sptbn2
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spectrin beta, non-erythrocytic 2
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decreases expression
|
EXP
|
lead acetate results in decreased expression of SPTBN2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:4,761,236...4,804,006
Ensembl chr19:4,761,195...4,802,388
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| G
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Sptssa
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serine palmitoyltransferase, small subunit A
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SPTSSA mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:54,692,159...54,703,357
Ensembl chr12:54,692,177...54,703,358
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| G
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Spz1
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spermatogenic leucine zipper 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of SPZ1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr13:92,711,139...92,712,740
Ensembl chr13:92,711,144...92,712,680
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| G
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Sqstm1
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sequestosome 1
|
increases expression multiple interactions decreases expression
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EXP ISO
|
lead acetate results in increased expression of SQSTM1 mRNA [lead acetate results in increased abundance of Lead] which results in decreased expression of SQSTM1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SQSTM1 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of SQSTM1 mRNA lead acetate results in increased expression of SQSTM1 mRNA; lead acetate results in increased expression of SQSTM1 protein (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [lead acetate results in increased expression of SQSTM1 protein]; [sodium arsenite co-treated with lead acetate] results in increased expression of SQSTM1 protein; Chloroquine promotes the reaction [lead acetate results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [lead acetate results in increased expression of SQSTM1 protein]; SRT1720 inhibits the reaction [lead acetate results in increased expression of SQSTM1 protein] lead acetate results in decreased expression of SQSTM1 protein
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CTD |
PMID:29746905 PMID:32879255 PMID:34842334 PMID:36652739 PMID:36840722 PMID:38072110 PMID:38568856 PMID:39276841 More...
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NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
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| G
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Src
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Rous sarcoma oncogene
|
multiple interactions increases phosphorylation
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ISO
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4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead acetate results in increased phosphorylation of SRC protein]; EGFR mutant form inhibits the reaction [lead acetate results in increased phosphorylation of SRC protein]
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CTD |
PMID:19133285 PMID:26926986 |
|
NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
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| G
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Srcin1
|
SRC kinase signaling inhibitor 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SRCIN1 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr11:97,400,166...97,466,059
Ensembl chr11:97,400,166...97,467,012
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|
| G
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Srebf1
|
sterol regulatory element binding transcription factor 1
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of SREBF1 protein SRT1720 inhibits the reaction [lead acetate results in increased expression of SREBF1 protein]
|
CTD |
PMID:34842334 |
|
NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
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| G
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Srebf2
|
sterol regulatory element binding factor 2
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of SREBF2 mRNA; lead acetate results in increased expression of SREBF2 protein SRT1720 inhibits the reaction [lead acetate results in increased expression of SREBF2 protein]
|
CTD |
PMID:29908845 PMID:34842334 |
|
NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580
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| G
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Sri
|
sorcin
|
increases expression
|
ISO
|
lead acetate results in increased expression of SRI mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 5:8,096,078...8,119,314
Ensembl chr 5:8,096,078...8,119,379
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| G
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Srr
|
serine racemase
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SRR mRNA; lead acetate results in decreased expression of SRR protein
|
CTD |
PMID:25242007 |
|
NCBI chr11:74,794,853...74,818,427
Ensembl chr11:74,797,185...74,816,774
|
|
| G
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Srsf10
|
serine and arginine-rich splicing factor 10
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SRSF10 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:135,582,454...135,597,219
Ensembl chr 4:135,583,058...135,597,219
|
|
| G
|
Srsf2
|
serine and arginine-rich splicing factor 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SRSF2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:116,740,723...116,744,511
Ensembl chr11:116,740,727...116,743,920
|
|
| G
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Srsf5
|
serine and arginine-rich splicing factor 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SRSF5 mRNA
|
CTD |
PMID:21335049 |
|
NCBI chr12:80,992,308...80,997,277
Ensembl chr12:80,992,278...80,997,281
|
|
| G
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Srsf6
|
serine and arginine-rich splicing factor 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SRSF6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:162,773,428...162,779,041
Ensembl chr 2:162,773,448...162,779,041
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|
| G
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Srxn1
|
sulfiredoxin 1 homolog (S. cerevisiae)
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of SRXN1 mRNA
|
CTD |
PMID:25270620 PMID:38568856 |
|
NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296
|
|
| G
|
Ssbp1
|
single-stranded DNA binding protein 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SSBP1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:40,448,302...40,458,757
Ensembl chr 6:40,448,286...40,461,634
|
|
| G
|
Ssbp3
|
single-stranded DNA binding protein 3
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SSBP3 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 4:106,768,667...106,906,891
Ensembl chr 4:106,767,898...106,906,891
|
|
| G
|
Ssh3
|
slingshot protein phosphatase 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SSH3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:4,311,696...4,319,261
Ensembl chr19:4,311,696...4,319,208
|
|
| G
|
Sspn
|
sarcospan
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SSPN mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 6:145,860,423...145,910,951
Ensembl chr 6:145,877,367...145,910,949 Ensembl chr 6:145,877,367...145,910,949
|
|
| G
|
Ssr3
|
signal sequence receptor, gamma
|
increases expression
|
ISO
|
lead acetate results in increased expression of SSR3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:65,287,078...65,299,974
Ensembl chr 3:65,287,076...65,300,044
|
|
| G
|
Sstr4
|
somatostatin receptor 4
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SSTR4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 2:148,237,297...148,238,684
Ensembl chr 2:148,237,264...148,238,687
|
|
| G
|
St13
|
suppression of tumorigenicity 13
|
affects expression
|
EXP
|
lead acetate affects the expression of ST13 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr15:81,247,869...81,284,278
Ensembl chr15:81,247,870...81,284,278
|
|
| G
|
St3gal1
|
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ST3GAL1 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr15:66,974,724...67,048,575
Ensembl chr15:66,974,724...67,048,679
|
|
| G
|
St6galnac1
|
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of ST6GALNAC1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:116,655,851...116,666,333
Ensembl chr11:116,655,851...116,666,333
|
|
| G
|
Stac
|
src homology three (SH3) and cysteine rich domain
|
increases expression
|
ISO
|
lead acetate results in increased expression of STAC mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:111,386,476...111,519,673
Ensembl chr 9:111,390,505...111,519,416
|
|
| G
|
Stac2
|
SH3 and cysteine rich domain 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of STAC2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:97,927,449...97,944,288
Ensembl chr11:97,927,449...97,944,288
|
|
| G
|
Stambpl1
|
STAM binding protein like 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of STAMBPL1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:34,169,629...34,217,733
Ensembl chr19:34,169,629...34,217,733
|
|
| G
|
Star
|
steroidogenic acute regulatory protein
|
decreases expression multiple interactions
|
EXP ISO
|
lead acetate results in decreased expression of STAR mRNA; lead acetate results in decreased expression of STAR protein [lead acetate results in increased abundance of Lead] which results in decreased expression of STAR mRNA; Glycine inhibits the reaction [lead acetate results in decreased expression of STAR mRNA]; lead acetate inhibits the reaction [Bucladesine results in increased expression of STAR protein]; Taurine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of STAR mRNA]
|
CTD |
PMID:11213355 PMID:12647776 PMID:22806249 PMID:25981801 PMID:26558472 PMID:36088639 PMID:36484981 More...
|
|
NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
|
|
| G
|
Stat1
|
signal transducer and activator of transcription 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of STAT1 protein; baricitinib inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of STAT1 protein]
|
CTD |
PMID:32428222 |
|
NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
|
|
| G
|
Stat3
|
signal transducer and activator of transcription 3
|
increases phosphorylation decreases expression
|
ISO
|
lead acetate results in increased phosphorylation of STAT3 protein lead acetate results in decreased expression of STAT3 mRNA
|
CTD |
PMID:26542248 PMID:38568856 |
|
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
|
|
| G
|
Stat5b
|
signal transducer and activator of transcription 5B
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of STAT5B intron
|
CTD |
PMID:33445541 |
|
NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550
|
|
| G
|
Stc1
|
stanniocalcin 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of STC1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:69,266,738...69,278,850
Ensembl chr14:69,266,687...69,279,253
|
|
| G
|
Stc2
|
stanniocalcin 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of STC2 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr11:31,309,441...31,320,061
Ensembl chr11:31,307,307...31,320,074
|
|
| G
|
Steap1
|
six transmembrane epithelial antigen of the prostate 1
|
affects expression
|
ISO
|
lead acetate affects the expression of STEAP1 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 5:5,786,322...5,799,317
Ensembl chr 5:5,786,317...5,799,326
|
|
| G
|
Steap3
|
STEAP family member 3
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of STEAP3 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr 1:120,154,137...120,198,810
Ensembl chr 1:120,118,487...120,200,435
|
|
| G
|
Steap4
|
STEAP family member 4
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of STEAP4 mRNA
|
CTD |
PMID:22609695 PMID:36539177 |
|
NCBI chr 5:8,010,472...8,032,213
Ensembl chr 5:8,010,457...8,032,213
|
|
| G
|
Stim1
|
stromal interaction molecule 1
|
multiple interactions
|
ISO EXP
|
lead acetate inhibits the reaction [STIM1 protein binds to ORAI1 protein]
|
CTD |
PMID:38281554 |
|
NCBI chr 7:101,909,279...102,086,525
Ensembl chr 7:101,917,013...102,086,526
|
|
| G
|
Stip1
|
stress-induced phosphoprotein 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of STIP1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:6,998,064...7,017,394
Ensembl chr19:6,998,070...7,017,335
|
|
| G
|
Stk10
|
serine/threonine kinase 10
|
increases expression
|
EXP
|
lead acetate results in increased expression of STK10 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr11:32,483,266...32,574,595
Ensembl chr11:32,483,305...32,574,587
|
|
| G
|
Stk32c
|
serine/threonine kinase 32C
|
affects expression
|
ISO
|
lead acetate affects the expression of STK32C protein
|
CTD |
PMID:36539177 |
|
NCBI chr 7:138,683,554...138,793,223
Ensembl chr 7:138,683,554...138,793,223
|
|
| G
|
Stmn1
|
stathmin 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of STMN1 mRNA
|
CTD |
PMID:36642386 |
|
NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154
|
|
| G
|
Stom
|
stomatin
|
multiple interactions increases expression
|
ISO EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of STOM mRNA lead acetate results in increased expression of STOM mRNA
|
CTD |
PMID:12634122 PMID:22609695 |
|
NCBI chr 2:35,204,002...35,227,021
Ensembl chr 2:35,203,998...35,226,988
|
|
| G
|
Stpg1
|
sperm tail PG rich repeat containing 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of STPG1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 4:135,221,971...135,265,015
Ensembl chr 4:135,222,101...135,265,114
|
|
| G
|
Stra6
|
stimulated by retinoic acid gene 6
|
affects expression
|
ISO
|
lead acetate affects the expression of STRA6 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 9:57,971,076...58,061,287
Ensembl chr 9:57,971,071...58,061,279
|
|
| G
|
Strip2
|
striatin interacting protein 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of STRIP2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 6:29,916,975...29,959,680
Ensembl chr 6:29,917,011...29,959,680
|
|
| G
|
Stx1a
|
syntaxin 1A (brain)
|
increases expression decreases expression
|
ISO
|
lead acetate results in increased expression of STX1A mRNA; lead acetate results in increased expression of STX1A protein lead acetate results in decreased expression of STX1A mRNA
|
CTD |
PMID:11578147 PMID:27984133 |
|
NCBI chr 5:135,051,473...135,079,954
Ensembl chr 5:135,052,336...135,079,954
|
|
| G
|
Stx1b
|
syntaxin 1B
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of STX1B mRNA
|
CTD |
PMID:27984133 |
|
NCBI chr 7:127,403,072...127,423,703
Ensembl chr 7:127,403,072...127,423,721
|
|
| G
|
Suclg1
|
succinate-CoA ligase, GDP-forming, alpha subunit
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SUCLG1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 6:73,225,488...73,253,890
Ensembl chr 6:73,225,365...73,253,894
|
|
| G
|
Sucnr1
|
succinate receptor 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of SUCNR1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:59,989,290...59,994,987
Ensembl chr 3:59,989,290...59,994,987
|
|
| G
|
Sulf1
|
sulfatase 1
|
affects expression
|
ISO
|
lead acetate affects the expression of SULF1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:12,762,421...12,946,090
Ensembl chr 1:12,762,501...12,931,416
|
|
| G
|
Sult1c2
|
sulfotransferase family, cytosolic, 1C, member 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SULT1C2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr17:54,136,665...54,152,986
Ensembl chr17:54,136,665...54,153,367
|
|
| G
|
Sult1e1
|
sulfotransferase family 1E, member 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SULT1E1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453
|
|
| G
|
Sumo2
|
small ubiquitin-like modifier 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of SUMO2 protein
|
CTD |
PMID:38072110 |
|
NCBI chr11:115,413,935...115,427,056
Ensembl chr11:115,413,928...115,427,102
|
|
| G
|
Sumo3
|
small ubiquitin-like modifier 3
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of SUMO3 protein
|
CTD |
PMID:38072110 |
|
NCBI chr10:77,441,931...77,454,165
Ensembl chr10:77,441,931...77,454,165
|
|
| G
|
Sun2
|
Sad1 and UNC84 domain containing 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of SUN2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:79,608,269...79,626,757
Ensembl chr15:79,608,271...79,626,737
|
|
| G
|
Sun5
|
Sad1 and UNC84 domain containing 5
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of SUN5 promoter
|
CTD |
PMID:33445541 |
|
NCBI chr 2:153,698,108...153,713,281
Ensembl chr 2:153,698,108...153,713,004
|
|
| G
|
Susd2
|
sushi domain containing 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SUSD2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr10:75,472,453...75,479,842
Ensembl chr10:75,472,540...75,479,842
|
|
| G
|
Suv39h1
|
suppressor of variegation 3-9 1
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of SUV39H1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr X:7,927,401...7,940,994
Ensembl chr X:7,927,410...7,940,999
|
|
| G
|
Sv2c
|
synaptic vesicle glycoprotein 2c
|
decreases expression multiple interactions
|
EXP ISO
|
lead acetate results in decreased expression of SV2C mRNA; lead acetate results in decreased expression of SV2C protein REST protein promotes the reaction [lead acetate results in decreased expression of SV2C mRNA]; REST protein promotes the reaction [lead acetate results in decreased expression of SV2C protein]
|
CTD |
PMID:29505838 |
|
NCBI chr13:96,091,102...96,270,837
Ensembl chr13:96,091,102...96,269,085
|
|
| G
|
Sval2
|
seminal vesicle antigen-like 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of SVAL2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:41,837,241...41,841,347
Ensembl chr 6:41,829,923...41,841,347
|
|
| G
|
Sycn
|
syncollin
|
increases expression decreases expression
|
EXP
|
lead acetate results in increased expression of SYCN mRNA lead acetate results in decreased expression of SYCN mRNA
|
CTD |
PMID:20542052 PMID:22609695 |
|
NCBI chr 7:28,240,310...28,241,635
Ensembl chr 7:28,240,310...28,241,634
|
|
| G
|
Syn1
|
synapsin I
|
decreases phosphorylation multiple interactions decreases expression increases expression
|
ISO EXP
|
lead acetate results in decreased phosphorylation of SYN1 protein [lead acetate results in increased abundance of Lead] which results in decreased expression of SYN1 protein; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SYN1 protein]; Hemin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SYN1 protein] lead acetate results in decreased expression of SYN1 protein lead acetate results in increased expression of SYN1 mRNA
|
CTD |
PMID:17047031 PMID:24260418 PMID:30121340 PMID:36096218 |
|
NCBI chr X:20,726,750...20,787,157
Ensembl chr X:20,726,750...20,787,243
|
|
| G
|
Syn3
|
synapsin III
|
increases expression
|
EXP
|
lead acetate results in increased expression of SYN3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr10:85,884,610...86,336,730
Ensembl chr10:85,890,989...86,334,760
|
|
| G
|
Syngap1
|
synaptic Ras GTPase activating protein 1 homolog (rat)
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of SYNGAP1 protein
|
CTD |
PMID:39947421 |
|
NCBI chr17:27,160,186...27,191,408
Ensembl chr17:27,160,227...27,191,408
|
|
| G
|
Syp
|
synaptophysin
|
multiple interactions decreases expression increases expression
|
ISO EXP
|
BDNF protein inhibits the reaction [lead acetate results in decreased expression of SYP protein] [lead acetate results in increased abundance of Lead] which results in decreased expression of SYP mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of SYP protein [[lead acetate results in increased abundance of Lead] which co-treated with APP protein modified form] results in decreased expression of SYP protein; [lead acetate results in increased abundance of Lead] promotes the reaction [[APP protein co-treated with APP protein modified form] results in decreased expression of SYP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in decreased expression of SYP protein]; [lead acetate results in increased abundance of Lead] which results in decreased expression of SYP protein lead acetate results in increased expression of SYP protein
|
CTD |
PMID:17047031 PMID:20375082 PMID:26660114 PMID:27771255 PMID:27984133 PMID:31843630 More...
|
|
NCBI chr X:7,504,819...7,519,495
Ensembl chr X:7,504,710...7,519,495
|
|
| G
|
Syt1
|
synaptotagmin I
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SYT1 protein
|
CTD |
PMID:27984133 |
|
NCBI chr10:108,333,511...108,846,852
Ensembl chr10:108,333,511...108,846,843
|
|
| G
|
Syt2
|
synaptotagmin II
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of SYT2 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 1:134,574,319...134,680,887
Ensembl chr 1:134,574,415...134,690,331
|
|
| G
|
Syt8
|
synaptotagmin VIII
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SYT8 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:141,988,195...141,994,136
Ensembl chr 7:141,988,587...141,994,133
|
|
| G
|
Sytl1
|
synaptotagmin-like 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of SYTL1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:132,980,401...132,990,398
Ensembl chr 4:132,980,401...132,990,424
|
|
| G
|
Sytl3
|
synaptotagmin-like 3
|
decreases expression increases expression
|
EXP
|
lead acetate results in decreased expression of SYTL3 mRNA lead acetate results in increased expression of SYTL3 mRNA
|
CTD |
PMID:21829687 PMID:22609695 |
|
NCBI chr17:6,925,633...7,005,449
Ensembl chr17:6,926,492...7,005,443
|
|
| G
|
T
|
brachyury, T-box transcription factor T
|
increases expression
|
EXP
|
lead acetate results in increased expression of T mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr17:8,653,255...8,661,328
Ensembl chr17:8,653,255...8,661,328
|
|
| G
|
Tacc2
|
transforming, acidic coiled-coil containing protein 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TACC2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:130,154,735...130,369,435
Ensembl chr 7:130,179,168...130,366,515
|
|
| G
|
Tacr3
|
tachykinin receptor 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TACR3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:134,534,768...134,640,342
Ensembl chr 3:134,534,768...134,640,340
|
|
| G
|
Tagln
|
transgelin
|
increases expression
|
ISO
|
lead acetate results in increased expression of TAGLN mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356
|
|
| G
|
Tal2
|
T cell acute lymphocytic leukemia 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of TAL2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:53,779,701...53,788,712
Ensembl chr 4:53,779,705...53,788,712
|
|
| G
|
Taldo1
|
transaldolase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of TALDO1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:140,972,073...140,982,889
Ensembl chr 7:140,972,112...140,982,881
|
|
| G
|
Tars1
|
threonyl-tRNA synthetase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of TARS1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr15:11,383,749...11,399,744
Ensembl chr15:11,382,387...11,399,751
|
|
| G
|
Tas2r119
|
taste receptor, type 2, member 119
|
increases expression
|
EXP
|
lead acetate results in increased expression of TAS2R119 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:32,177,435...32,178,440
Ensembl chr15:32,177,435...32,178,440
|
|
| G
|
Tat
|
tyrosine aminotransferase
|
decreases expression
|
ISO EXP
|
lead acetate results in decreased expression of TAT mRNA
|
CTD |
PMID:11578147 PMID:22609695 PMID:25270620 |
|
NCBI chr 8:110,712,710...110,726,436
Ensembl chr 8:110,717,069...110,726,435
|
|
| G
|
Tbc1d14
|
TBC1 domain family, member 14
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of TBC1D14 exon; [lead acetate results in increased abundance of Lead] which results in increased methylation of TBC1D14 intron; [lead acetate results in increased abundance of Lead] which results in increased methylation of TBC1D14 promoter
|
CTD |
PMID:33445541 |
|
NCBI chr 5:36,647,948...36,743,611
Ensembl chr 5:36,647,948...36,750,620
|
|
| G
|
Tbc1d16
|
TBC1 domain family, member 16
|
affects expression
|
EXP
|
lead acetate affects the expression of TBC1D16 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:119,033,869...119,119,354
Ensembl chr11:119,033,871...119,119,325
|
|
| G
|
Tbcb
|
tubulin folding cofactor B
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TBCB mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:29,923,554...29,931,622
Ensembl chr 7:29,923,556...29,931,697
|
|
| G
|
Tbcd
|
tubulin-specific chaperone d
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of TBCD mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:121,342,817...121,507,996
Ensembl chr11:121,342,775...121,507,990
|
|
| G
|
Tbl1xr1
|
transducin (beta)-like 1X-linked receptor 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of TBL1XR1 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 3:22,130,756...22,270,758
Ensembl chr 3:22,130,816...22,270,758
|
|
| G
|
Tbrg1
|
transforming growth factor beta regulated gene 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of TBRG1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 9:37,560,478...37,568,608
Ensembl chr 9:37,560,059...37,568,608
|
|
| G
|
Tbx18
|
T-box18
|
increases expression
|
ISO
|
lead acetate results in increased expression of TBX18 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 9:87,584,853...87,613,313
Ensembl chr 9:87,584,853...87,613,313
|
|
| G
|
Tbx3os2
|
T-box 3, opposite strand 2
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of TBX3OS2 intron
|
CTD |
PMID:33445541 |
|
NCBI chr 5:119,823,153...119,829,283
Ensembl chr 5:119,822,760...119,848,430
|
|
| G
|
Tc2n
|
tandem C2 domains, nuclear
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TC2N mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr12:101,611,705...101,685,178
Ensembl chr12:101,611,702...101,684,782
|
|
| G
|
Tceal7
|
transcription elongation factor A (SII)-like 7
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in increased expression of TCEAL7 protein
|
CTD |
PMID:38072110 |
|
NCBI chr X:135,124,790...135,126,849
Ensembl chr X:135,115,528...135,126,849
|
|
| G
|
Tceanc
|
transcription elongation factor A (SII) N-terminal and central domain containing
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of TCEANC gene
|
CTD |
PMID:29571894 |
|
NCBI chr X:165,282,806...165,301,594
Ensembl chr X:165,282,808...165,301,563
|
|
| G
|
Tcf7
|
transcription factor 7, T cell specific
|
increases expression
|
ISO
|
lead acetate results in increased expression of TCF7 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr11:52,137,347...52,174,211
Ensembl chr11:52,143,198...52,174,158
|
|
| G
|
Tcf7l1
|
transcription factor 7 like 1 (T cell specific, HMG box)
|
increases expression
|
EXP
|
lead acetate results in increased expression of TCF7L1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:72,603,354...72,766,028
Ensembl chr 6:72,603,361...72,766,237
|
|
| G
|
Tcf7l2
|
transcription factor 7 like 2, T cell specific, HMG box
|
increases expression
|
EXP
|
lead acetate results in increased expression of TCF7L2 mRNA
|
CTD |
PMID:36183778 |
|
NCBI chr19:55,730,227...55,922,091
Ensembl chr19:55,730,252...55,922,086
|
|
| G
|
Tcstv6a
|
Tcstv family member 6A
|
increases expression
|
EXP
|
lead acetate results in increased expression of TCSTV6A mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr13:120,306,880...120,308,226
Ensembl chr13:120,297,542...120,308,106
|
|
| G
|
Tctn2
|
tectonic family member 2
|
affects methylation
|
ISO
|
lead acetate affects the methylation of TCTN2 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 5:124,736,812...124,765,803
Ensembl chr 5:124,736,812...124,765,803
|
|
| G
|
Tdo2
|
tryptophan 2,3-dioxygenase
|
increases expression
|
ISO
|
lead acetate results in increased expression of TDO2 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509
|
|
| G
|
Tdp2
|
tyrosyl-DNA phosphodiesterase 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of TDP2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:25,015,642...25,026,136
Ensembl chr13:25,015,662...25,026,136
|
|
| G
|
Tec
|
tec protein tyrosine kinase
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TEC mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:72,913,061...73,025,997
Ensembl chr 5:72,913,059...73,025,826
|
|
| G
|
Tef
|
thyrotroph embryonic factor
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of TEF gene
|
CTD |
PMID:29571894 |
|
NCBI chr15:81,686,874...81,711,064
Ensembl chr15:81,686,622...81,711,064
|
|
| G
|
Telo2
|
telomere maintenance 2
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of TELO2 mRNA
|
CTD |
PMID:22609695 PMID:38568856 |
|
NCBI chr17:25,318,543...25,334,951
Ensembl chr17:25,318,544...25,334,941
|
|
| G
|
Tenm3
|
teneurin transmembrane protein 3
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of TENM3 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 8:48,678,700...51,370,255
Ensembl chr 8:48,680,717...49,296,986
|
|
| G
|
Tespa1
|
thymocyte expressed, positive selection associated 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of TESPA1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr10:130,158,696...130,199,338
Ensembl chr10:130,158,739...130,199,980
|
|
| G
|
Tet1
|
tet methylcytosine dioxygenase 1
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of TET1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr10:62,640,349...62,723,242
Ensembl chr10:62,640,349...62,744,775
|
|
| G
|
Tex101
|
testis expressed gene 101
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of TEX101 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:24,367,437...24,371,475
Ensembl chr 7:24,367,432...24,376,100
|
|
| G
|
Tex15
|
testis expressed gene 15 meiosis and synapsis associated
|
increases expression
|
ISO
|
lead acetate results in increased expression of TEX15 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 8:34,006,712...34,082,531
Ensembl chr 8:34,006,766...34,075,610
|
|
| G
|
Tfap2d
|
transcription factor AP-2, delta
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of TFAP2D gene
|
CTD |
PMID:29571894 |
|
NCBI chr 1:19,173,246...19,244,172
Ensembl chr 1:19,173,246...19,236,570
|
|
| G
|
Tfcp2l1
|
transcription factor CP2-like 1
|
increases expression decreases expression
|
ISO
|
lead acetate results in increased expression of TFCP2L1 mRNA lead acetate results in decreased expression of TFCP2L1 mRNA
|
CTD |
PMID:22641619 PMID:38568856 |
|
NCBI chr 1:118,555,646...118,612,898
Ensembl chr 1:118,555,675...118,612,898
|
|
| G
|
Tff2
|
trefoil factor 2 (spasmolytic protein 1)
|
increases expression
|
EXP
|
lead acetate results in increased expression of TFF2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr17:31,360,036...31,363,256
Ensembl chr17:31,360,023...31,363,256
|
|
| G
|
Tfpi2
|
tissue factor pathway inhibitor 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of TFPI2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:3,962,589...3,988,977
Ensembl chr 6:3,962,595...3,988,919
|
|
| G
|
Tfrc
|
transferrin receptor
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of TFRC mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of TFRC protein; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of TFRC mRNA]; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of TFRC protein]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of TFRC mRNA]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of TFRC protein]
|
CTD |
PMID:36642386 PMID:39276841 |
|
NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612
|
|
| G
|
Tgfb1
|
transforming growth factor, beta 1
|
increases expression multiple interactions affects expression
|
EXP ISO
|
lead acetate results in increased expression of TGFB1 mRNA naringenin inhibits the reaction [lead acetate results in increased expression of TGFB1 protein] [[lead acetate results in increased abundance of Lead] co-treated with [IL4 protein co-treated with IL13 protein]] results in increased expression of TGFB1 protein lead acetate affects the expression of TGFB1 protein
|
CTD |
PMID:21322097 PMID:34352350 PMID:36807407 PMID:38568856 |
|
NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
|
|
| G
|
Tgfb2
|
transforming growth factor, beta 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TGFB2 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186
|
|
| G
|
Tgfbi
|
transforming growth factor, beta induced
|
increases expression
|
ISO
|
lead acetate results in increased expression of TGFBI mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:56,757,399...56,787,172
Ensembl chr13:56,757,336...56,787,375
|
|
| G
|
Tgfbr3
|
transforming growth factor, beta receptor III
|
increases expression
|
ISO
|
lead acetate results in increased expression of TGFBR3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:107,254,433...107,437,495
Ensembl chr 5:107,254,436...107,437,495
|
|
| G
|
Tgm1
|
transglutaminase 1, K polypeptide
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TGM1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:55,937,466...55,951,378
Ensembl chr14:55,937,466...55,951,383
|
|
| G
|
Tgoln1
|
trans-golgi network protein
|
decreases expression increases expression
|
EXP
|
lead acetate results in decreased expression of TGOLN1 mRNA lead acetate results in increased expression of TGOLN1 mRNA
|
CTD |
PMID:21829687 PMID:25270620 |
|
NCBI chr 6:72,585,403...72,593,983
Ensembl chr 6:72,585,415...72,593,983
|
|
| G
|
Thap6
|
THAP domain containing 6
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of THAP6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:92,110,741...92,119,996
Ensembl chr 5:92,110,248...92,170,798 Ensembl chr 5:92,110,248...92,170,798
|
|
| G
|
Thbd
|
thrombomodulin
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of THBD mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108
|
|
| G
|
Thbs1
|
thrombospondin 1
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of THBS1 mRNA
|
CTD |
PMID:22609695 PMID:37939567 |
|
NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614
|
|
| G
|
Thbs2
|
thrombospondin 2
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of THBS2 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr17:14,885,762...14,914,524
Ensembl chr17:14,885,762...14,914,497
|
|
| G
|
Thoc5
|
THO complex 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of THOC5 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:4,845,339...4,878,867
Ensembl chr11:4,845,320...4,878,867
|
|
| G
|
Thsd1
|
thrombospondin, type I, domain 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of THSD1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 8:22,711,623...22,752,973
Ensembl chr 8:22,717,329...22,751,350
|
|
| G
|
Thumpd3
|
THUMP domain containing 3
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of THUMPD3 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 6:113,023,292...113,045,239
Ensembl chr 6:113,023,186...113,045,234
|
|
| G
|
Tigd5
|
tigger transposable element derived 5
|
increases expression
|
ISO
|
lead acetate results in increased expression of TIGD5 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:75,781,584...75,786,384
Ensembl chr15:75,781,584...75,786,384
|
|
| G
|
Timd2
|
T cell immunoglobulin and mucin domain containing 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of TIMD2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:46,559,787...46,597,934
Ensembl chr11:46,559,787...46,597,888
|
|
| G
|
Timp1
|
tissue inhibitor of metalloproteinase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of TIMP1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974
|
|
| G
|
Tinagl1
|
tubulointerstitial nephritis antigen-like 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of TINAGL1 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 4:130,059,393...130,068,915
Ensembl chr 4:130,058,247...130,068,915
|
|
| G
|
Tiparp
|
TCDD-inducible poly(ADP-ribose) polymerase
|
increases expression
|
ISO
|
lead acetate results in increased expression of TIPARP mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:65,435,868...65,462,939
Ensembl chr 3:65,435,831...65,462,939
|
|
| G
|
Tjp1
|
tight junction protein 1
|
multiple interactions decreases expression
|
ISO EXP
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of TJP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of TJP1 protein] [lead acetate results in increased abundance of Lead] which results in decreased expression of TJP1 protein
|
CTD |
PMID:24200059 PMID:31730887 |
|
NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
|
|
| G
|
Tjp3
|
tight junction protein 3
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of TJP3 mRNA lead acetate results in decreased expression of TJP3 mRNA
|
CTD |
PMID:20542052 PMID:38568856 |
|
NCBI chr10:81,109,022...81,127,415
Ensembl chr10:81,109,041...81,127,415
|
|
| G
|
Tk1
|
thymidine kinase 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of TK1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:117,706,345...117,716,913
Ensembl chr11:117,706,352...117,716,918
|
|
| G
|
Tktl1
|
transketolase-like 1
|
increases expression decreases methylation
|
ISO
|
lead acetate results in increased expression of TKTL1 mRNA lead acetate results in decreased methylation of TKTL1 gene
|
CTD |
PMID:22641619 PMID:29571894 |
|
NCBI chr X:73,220,865...73,252,104
Ensembl chr X:73,220,865...73,252,106
|
|
| G
|
Tln2
|
talin 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of TLN2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:67,124,371...67,541,357
Ensembl chr 9:67,124,369...67,466,985
|
|
| G
|
Tlnrd1
|
talin rod domain containing 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of TLNRD1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:83,529,703...83,533,549
Ensembl chr 7:83,529,081...83,533,513
|
|
| G
|
Tlr4
|
toll-like receptor 4
|
multiple interactions increases expression
|
EXP
|
3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in increased expression of TLR4 protein]
|
CTD |
PMID:37385299 |
|
NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
|
|
| G
|
Tlr5
|
toll-like receptor 5
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of TLR5 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 1:182,782,317...182,804,010
Ensembl chr 1:182,782,353...182,804,010
|
|
| G
|
Tlr6
|
toll-like receptor 6
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TLR6 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 5:65,109,373...65,128,387
Ensembl chr 5:65,109,374...65,117,440
|
|
| G
|
Tlr8
|
toll-like receptor 8
|
increases expression
|
EXP
|
lead acetate results in increased expression of TLR8 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr X:166,024,119...166,047,325
Ensembl chr X:166,025,692...166,047,325
|
|
| G
|
Tlr9
|
toll-like receptor 9
|
increases expression
|
EXP
|
lead acetate results in increased expression of TLR9 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082
|
|
| G
|
Tlx1
|
T cell leukemia, homeobox 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of TLX1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr19:45,138,531...45,145,382
Ensembl chr19:45,139,119...45,145,382
|
|
| G
|
Tm4sf1
|
transmembrane 4 superfamily member 1
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multiple interactions
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ISO
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[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TM4SF1 mRNA
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CTD |
PMID:12634122 |
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NCBI chr 3:57,193,038...57,295,150
Ensembl chr 3:57,193,032...57,209,409 Ensembl chr 3:57,193,032...57,209,409
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Tm4sf19
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transmembrane 4 L six family member 19
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decreases expression
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ISO
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lead acetate results in decreased expression of TM4SF19 mRNA
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CTD |
PMID:22641619 |
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NCBI chr16:32,218,823...32,227,397
Ensembl chr16:32,219,324...32,227,045
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Tm4sf20
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transmembrane 4 L six family member 20
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decreases expression
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EXP
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lead acetate results in decreased expression of TM4SF20 mRNA
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CTD |
PMID:22609695 |
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NCBI chr 1:82,734,368...82,746,182
Ensembl chr 1:82,734,370...82,746,182
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Tm4sf5
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transmembrane 4 superfamily member 5
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decreases expression
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EXP
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lead acetate results in decreased expression of TM4SF5 mRNA
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CTD |
PMID:22609695 |
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NCBI chr11:70,396,100...70,402,009
Ensembl chr11:70,396,070...70,402,004
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Tmbim6
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transmembrane BAX inhibitor motif containing 6
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multiple interactions
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ISO
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[sodium arsenite co-treated with lead acetate] results in decreased expression of TMBIM6 protein
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CTD |
PMID:38072110 |
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NCBI chr15:99,290,828...99,307,930
Ensembl chr15:99,290,763...99,307,930
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Tmed4
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transmembrane p24 trafficking protein 4
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increases expression
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EXP
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lead acetate results in increased expression of TMED4 mRNA
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CTD |
PMID:21829687 |
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NCBI chr11:6,220,714...6,224,837
Ensembl chr11:6,220,369...6,224,870
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Tmed9
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transmembrane p24 trafficking protein 9
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increases expression
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ISO
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lead acetate results in increased expression of TMED9 mRNA
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CTD |
PMID:38568856 |
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NCBI chr13:55,740,948...55,745,510
Ensembl chr13:55,721,545...55,745,510
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Tmem144
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transmembrane protein 144
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increases expression
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ISO
|
lead acetate results in increased expression of TMEM144 mRNA
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CTD |
PMID:22641619 |
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NCBI chr 3:79,719,871...79,760,093
Ensembl chr 3:79,719,871...79,760,080
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Tmem158
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transmembrane protein 158
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increases expression
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ISO
|
lead acetate results in increased expression of TMEM158 mRNA
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CTD |
PMID:22839698 |
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NCBI chr 9:123,088,122...123,089,854
Ensembl chr 9:123,088,118...123,089,829
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Tmem176a
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transmembrane protein 176A
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increases expression
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EXP
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lead acetate results in increased expression of TMEM176A mRNA
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CTD |
PMID:21829687 |
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NCBI chr 6:48,818,417...48,822,298
Ensembl chr 6:48,817,853...48,824,005
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Tmem204
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transmembrane protein 204
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increases expression
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EXP
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lead acetate results in increased expression of TMEM204 mRNA
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CTD |
PMID:20542052 |
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NCBI chr17:25,276,676...25,300,088
Ensembl chr17:25,276,676...25,302,565
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Tmem219
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transmembrane protein 219
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decreases expression
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EXP
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lead acetate results in decreased expression of TMEM219 mRNA
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CTD |
PMID:21829687 |
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NCBI chr 7:126,485,391...126,527,993
Ensembl chr 7:126,485,343...126,522,089
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Tmem254
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transmembrane protein 254
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decreases expression
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EXP
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lead acetate results in decreased expression of TMEM254 mRNA
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CTD |
PMID:25270620 |
|
NCBI chr14:25,923,722...25,928,096
Ensembl chr14:25,923,724...25,928,096
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Tmem255a
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transmembrane protein 255A
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increases expression
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ISO
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lead acetate results in increased expression of TMEM255A mRNA
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CTD |
PMID:22839698 |
|
NCBI chr X:37,285,450...37,341,373
Ensembl chr X:37,285,450...37,341,316
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Tmem40
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transmembrane protein 40
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decreases expression
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EXP
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lead acetate results in decreased expression of TMEM40 mRNA
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CTD |
PMID:25270620 |
|
NCBI chr 6:115,706,092...115,739,427
Ensembl chr 6:115,706,092...115,739,371
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Tmem54
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transmembrane protein 54
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increases expression
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ISO
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lead acetate results in increased expression of TMEM54 mRNA
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CTD |
PMID:38568856 |
|
NCBI chr 4:128,999,321...129,005,419
Ensembl chr 4:128,999,341...129,005,419
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Tmem63a
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transmembrane protein 63a
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increases expression
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ISO
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lead acetate results in increased expression of TMEM63A mRNA
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CTD |
PMID:22641619 |
|
NCBI chr 1:180,769,899...180,802,671
Ensembl chr 1:180,769,909...180,802,677
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Tmprss4
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transmembrane protease, serine 4
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increases expression
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EXP
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lead acetate results in increased expression of TMPRSS4 mRNA
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CTD |
PMID:22609695 |
|
NCBI chr 9:45,084,024...45,115,417
Ensembl chr 9:45,084,024...45,115,390
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Tmsb10
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thymosin beta 10
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increases expression
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EXP
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lead acetate results in increased expression of TMSB10 mRNA
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CTD |
PMID:21829687 |
|
NCBI chr 6:72,934,330...72,935,731
Ensembl chr 6:72,934,330...72,935,731
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Tmt1a
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thiol methyltransferase 1A1
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decreases expression
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ISO
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lead acetate results in decreased expression of METTL7A mRNA
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CTD |
PMID:38568856 |
|
NCBI chr15:100,201,969...100,227,882
Ensembl chr15:100,202,021...100,226,543
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Tmtc4
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transmembrane and tetratricopeptide repeat containing 4
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increases expression
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EXP
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lead acetate results in increased expression of TMTC4 mRNA
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CTD |
PMID:21829687 |
|
NCBI chr14:123,156,383...123,220,697
Ensembl chr14:123,156,383...123,221,447
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Tnc
|
tenascin C
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decreases expression affects expression
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ISO EXP
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lead acetate results in decreased expression of TNC mRNA lead acetate affects the expression of TNC protein
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CTD |
PMID:11578147 PMID:22613225 PMID:36539177 |
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NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252
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Tnf
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tumor necrosis factor
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multiple interactions increases expression increases secretion decreases expression
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ISO EXP
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2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; [lead acetate results in increased abundance of Lead] which results in increased expression of TNF mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of TNF protein; lead acetate promotes the reaction [Hemagglutinins results in increased secretion of TNF protein]; NFE2L2 protein affects the reaction [Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of TNF mRNA]]; NFE2L2 protein affects the reaction [Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of TNF protein]]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of TNF mRNA]; Rutin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of TNF protein] lead acetate results in increased expression of TNF mRNA; lead acetate results in increased expression of TNF protein 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lead acetate results in increased expression of TNF protein]; 3-methyladenine inhibits the reaction [lead acetate results in increased expression of TNF protein]; 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in increased expression of TNF protein]; Ascorbic Acid inhibits the reaction [lead acetate results in increased expression of TNF protein]; Cholecalciferol inhibits the reaction [lead acetate results in increased expression of TNF protein]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; coenzyme Q10 inhibits the reaction [lead acetate results in increased expression of TNF protein]; lead acetate promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; lead acetate promotes the reaction [Zinc Oxide results in increased expression of TNF protein]; lead acetate results in increased expression of and results in increased secretion of TNF protein; Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; naringenin inhibits the reaction [lead acetate results in increased expression of TNF protein]; Plant Oils inhibits the reaction [lead acetate results in increased expression of TNF protein]; Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [lead acetate results in increased expression of TNF protein]; Quercetin inhibits the reaction [lead acetate results in increased expression of TNF protein]; SB 203580 inhibits the reaction [lead acetate results in increased expression of TNF protein]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of TNF mRNA]; sinapinic acid inhibits the reaction [lead acetate results in increased expression of TNF protein]; sodium bisulfide inhibits the reaction [lead acetate results in increased expression of TNF protein]; sodium boranocarbonate inhibits the reaction [lead acetate results in increased expression of TNF protein]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of TNF protein] 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased secretion of TNF protein]; 3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in increased expression of TNF protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased secretion of TNF protein]; [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of TNF protein; [lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of TNF protein; [lead acetate results in increased abundance of Lead] which results in increased expression of TNF mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of TNF protein; [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of TNF protein; Celecoxib inhibits the reaction [lead acetate results in increased secretion of TNF protein]; chelerythrine inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; chelerythrine inhibits the reaction [lead acetate results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; MitoTEMPO inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of TNF protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of TNF protein]; NLRP3 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; U 0126 inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; U 0126 inhibits the reaction [lead acetate results in increased secretion of TNF protein] lead acetate results in decreased expression of TNF protein
|
CTD |
PMID:10936489 PMID:15302094 PMID:15843504 PMID:16581537 PMID:17047031 PMID:17512567 PMID:22728154 PMID:22839698 PMID:22952811 PMID:24222729 PMID:24530660 PMID:25088297 PMID:27492863 PMID:30251767 PMID:30980911 PMID:32116774 PMID:32208856 PMID:32879255 PMID:34051273 PMID:34553816 PMID:36308466 PMID:36539177 PMID:36807407 PMID:37385299 PMID:37397918 PMID:37471654 PMID:38180308 PMID:38281554 PMID:38530053 PMID:39032614 More...
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Tnfrsf11a
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tumor necrosis factor receptor superfamily, member 11a, NFKB activator
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increases expression
|
ISO
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lead acetate results in increased expression of TNFRSF11A mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:105,708,443...105,777,172
Ensembl chr 1:105,708,443...105,775,709
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| G
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Tnfrsf11b
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tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
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decreases expression multiple interactions
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ISO EXP
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lead acetate results in decreased expression of TNFRSF11B mRNA; lead acetate results in decreased expression of TNFRSF11B protein Ethanol promotes the reaction [lead acetate results in decreased expression of TNFRSF11B protein]
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CTD |
PMID:22641619 PMID:23376407 PMID:30312686 |
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NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880
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Tnfrsf12a
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tumor necrosis factor receptor superfamily, member 12a
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increases expression
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ISO
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lead acetate results in increased expression of TNFRSF12A mRNA
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CTD |
PMID:38568856 |
|
NCBI chr17:23,894,419...23,896,423
Ensembl chr17:23,894,419...23,896,442
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Tnfrsf19
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tumor necrosis factor receptor superfamily, member 19
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increases expression
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ISO
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lead acetate results in increased expression of TNFRSF19 mRNA
|
CTD |
PMID:37939567 |
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NCBI chr14:61,201,283...61,284,304
Ensembl chr14:61,201,324...61,283,939
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Tnfrsf1b
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tumor necrosis factor receptor superfamily, member 1b
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multiple interactions increases expression
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ISO EXP
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[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TNFRSF1B mRNA lead acetate results in increased expression of TNFRSF1B mRNA
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CTD |
PMID:12634122 PMID:21829687 |
|
NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440
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Tnfsf10
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tumor necrosis factor (ligand) superfamily, member 10
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multiple interactions increases expression
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ISO EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of TNFSF10 mRNA lead acetate results in increased expression of TNFSF10 mRNA
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CTD |
PMID:12634122 PMID:20542052 |
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NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576
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Tnfsf11
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tumor necrosis factor (ligand) superfamily, member 11
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increases expression multiple interactions
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ISO
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lead acetate results in increased expression of TNFSF11 protein Ethanol promotes the reaction [lead acetate results in increased expression of TNFSF11 protein]
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CTD |
PMID:23376407 |
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NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
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Tnfsf13b
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tumor necrosis factor (ligand) superfamily, member 13b
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increases expression
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EXP
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lead acetate results in increased expression of TNFSF13B mRNA
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CTD |
PMID:20542052 |
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NCBI chr 8:10,056,637...10,086,000
Ensembl chr 8:10,056,467...10,089,072
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Tnfsf14
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tumor necrosis factor (ligand) superfamily, member 14
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decreases expression
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ISO
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lead acetate results in decreased expression of TNFSF14 mRNA
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CTD |
PMID:38568856 |
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NCBI chr17:57,496,437...57,501,182
Ensembl chr17:57,496,492...57,501,177
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Tnfsf9
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tumor necrosis factor (ligand) superfamily, member 9
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increases expression
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ISO
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lead acetate results in increased expression of TNFSF9 mRNA
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CTD |
PMID:38568856 |
|
NCBI chr17:57,412,113...57,414,757
Ensembl chr17:57,412,325...57,414,757
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Tnik
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TRAF2 and NCK interacting kinase
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decreases expression
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ISO
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lead acetate results in decreased expression of TNIK mRNA
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CTD |
PMID:22641619 |
|
NCBI chr 3:28,317,362...28,724,734
Ensembl chr 3:28,317,363...28,730,007
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Tnk1
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tyrosine kinase, non-receptor, 1
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increases expression
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EXP
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lead acetate results in increased expression of TNK1 mRNA
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CTD |
PMID:22609695 |
|
NCBI chr11:69,741,389...69,749,556
Ensembl chr11:69,741,831...69,749,556
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Tnni2
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troponin I, skeletal, fast 2
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decreases expression
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ISO
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lead acetate results in decreased expression of TNNI2 mRNA
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CTD |
PMID:38568856 |
|
NCBI chr 7:141,995,553...141,998,147
Ensembl chr 7:141,995,545...141,998,147
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Tnnt1
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troponin T1, skeletal, slow
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decreases expression
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ISO
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lead acetate results in decreased expression of TNNT1 mRNA
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CTD |
PMID:22641619 |
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NCBI chr 7:4,507,568...4,518,974
Ensembl chr 7:4,507,569...4,519,381
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Tnp2
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transition protein 2
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multiple interactions
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EXP
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[lead acetate results in increased abundance of Lead] which results in decreased expression of TNP2 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of TNP2 protein
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CTD |
PMID:32142724 |
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NCBI chr16:10,605,799...10,606,519
Ensembl chr16:10,605,800...10,606,524
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Tnrc6a
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trinucleotide repeat containing 6a
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multiple interactions
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ISO EXP
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[lead acetate co-treated with zinc protoporphyrin] results in increased expression of TNRC6A mRNA [lead acetate results in increased abundance of Lead] which results in increased methylation of TNRC6A exon; [lead acetate results in increased abundance of Lead] which results in increased methylation of TNRC6A intron
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CTD |
PMID:22839698 PMID:33445541 |
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NCBI chr 7:122,630,324...122,794,519
Ensembl chr 7:122,723,108...122,794,519
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Tns1
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tensin 1
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decreases expression
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EXP
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lead acetate results in decreased expression of TNS1 mRNA
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CTD |
PMID:25270620 |
|
NCBI chr 1:73,949,391...74,163,707
Ensembl chr 1:73,949,390...74,163,608
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Tns2
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tensin 2
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decreases expression
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ISO
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lead acetate results in decreased expression of TNS2 mRNA
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CTD |
PMID:38568856 |
|
NCBI chr15:102,006,910...102,024,836
Ensembl chr15:102,008,848...102,024,836
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Top2a
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topoisomerase (DNA) II alpha
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decreases expression
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EXP
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lead acetate results in decreased expression of TOP2A mRNA
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CTD |
PMID:22613225 |
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NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015
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Tor4a
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torsin family 4, member A
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increases expression
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ISO
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lead acetate results in increased expression of TOR4A mRNA
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CTD |
PMID:38568856 |
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NCBI chr 2:25,082,732...25,086,825
Ensembl chr 2:25,082,978...25,086,898
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Tpcn2
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two pore segment channel 2
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decreases expression
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EXP
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lead acetate results in decreased expression of TPCN2 mRNA
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CTD |
PMID:22609695 |
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NCBI chr 7:144,735,370...144,837,743
Ensembl chr 7:144,740,261...144,837,748
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Tpsb2
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tryptase beta 2
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decreases expression
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EXP
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lead acetate results in decreased expression of TPSB2 mRNA
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CTD |
PMID:22609695 |
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NCBI chr17:25,585,282...25,587,070
Ensembl chr17:25,585,170...25,588,079
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Tpst1
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protein-tyrosine sulfotransferase 1
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increases expression
|
ISO
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lead acetate results in increased expression of TPST1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:130,102,167...130,164,575
Ensembl chr 5:130,102,167...130,164,570
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Traf1
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TNF receptor-associated factor 1
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decreases expression
|
EXP
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lead acetate results in decreased expression of TRAF1 mRNA
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CTD |
PMID:22609695 |
|
NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784
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Traf2
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TNF receptor-associated factor 2
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increases expression
|
EXP
|
lead acetate results in increased expression of TRAF2 mRNA
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CTD |
PMID:20542052 |
|
NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952
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Trat1
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T cell receptor associated transmembrane adaptor 1
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increases expression
|
EXP
|
lead acetate results in increased expression of TRAT1 mRNA
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CTD |
PMID:21829687 |
|
NCBI chr16:48,551,137...48,630,883
Ensembl chr16:48,551,137...48,592,384 Ensembl chr16:48,551,137...48,592,384
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Trbv13-2
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T cell receptor beta, variable 13-2
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decreases expression
|
EXP
|
lead acetate results in decreased expression of TRBV13-2 mRNA
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CTD |
PMID:21829687 |
|
NCBI chr 6:41,098,330...41,098,766
Ensembl chr 6:41,098,330...41,098,766
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Treml4
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triggering receptor expressed on myeloid cells-like 4
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increases expression
|
EXP
|
lead acetate results in increased expression of TREML4 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:48,571,229...48,582,635
Ensembl chr17:48,571,323...48,582,388
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Trex2
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three prime repair exonuclease 2
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increases expression
|
EXP
|
lead acetate results in increased expression of TREX2 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr X:72,477,311...72,478,949
Ensembl chr X:72,477,311...72,478,950
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Trf
|
transferrin
|
increases expression
|
ISO
|
lead acetate results in increased expression of TF protein
|
CTD |
PMID:21549428 |
|
NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
|
|
| G
|
Trhde
|
TRH-degrading enzyme
|
increases expression affects methylation
|
ISO
|
lead acetate results in increased expression of TRHDE mRNA lead acetate affects the methylation of TRHDE gene
|
CTD |
PMID:29571894 |
|
NCBI chr10:114,234,725...114,638,207
Ensembl chr10:114,234,726...114,638,212
|
|
| G
|
Trhr
|
thyrotropin releasing hormone receptor
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TRHR mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr15:44,059,314...44,099,308
Ensembl chr15:44,059,531...44,099,308
|
|
| G
|
Trib1
|
tribbles pseudokinase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of IFIT1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr15:59,520,503...59,528,948
Ensembl chr15:59,520,199...59,528,948
|
|
| G
|
Trib2
|
tribbles pseudokinase 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of TRIB2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr12:15,841,726...15,866,963
Ensembl chr12:15,841,728...15,866,923
|
|
| G
|
Trib3
|
tribbles pseudokinase 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of TRIB3 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952
|
|
| G
|
Trim16
|
tripartite motif-containing 16
|
increases expression
|
ISO
|
lead acetate results in increased expression of TRIM16 mRNA
|
CTD |
PMID:37939567 PMID:38568856 |
|
NCBI chr11:62,711,034...62,733,774
Ensembl chr11:62,711,057...62,741,634
|
|
| G
|
Trim25
|
tripartite motif-containing 25
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of TRIM25 protein
|
CTD |
PMID:38072110 |
|
NCBI chr11:88,890,194...88,911,119
Ensembl chr11:88,890,202...88,911,119
|
|
| G
|
Trim28
|
tripartite motif-containing 28
|
increases expression
|
ISO
|
lead acetate results in increased expression of TRIM28 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:12,758,079...12,764,959
Ensembl chr 7:12,733,041...12,764,962
|
|
| G
|
Trim29
|
tripartite motif-containing 29
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TRIM29 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 9:43,222,012...43,247,422
Ensembl chr 9:43,222,145...43,247,412
|
|
| G
|
Trim35
|
tripartite motif-containing 35
|
increases expression
|
EXP
|
lead acetate results in increased expression of TRIM35 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr14:66,534,474...66,548,873
Ensembl chr14:66,534,480...66,548,873
|
|
| G
|
Trim42
|
tripartite motif-containing 42
|
increases expression
|
EXP
|
lead acetate results in increased expression of TRIM42 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 9:97,231,615...97,252,011
Ensembl chr 9:97,231,615...97,252,011
|
|
| G
|
Trim59
|
tripartite motif-containing 59
|
increases expression
|
EXP
|
lead acetate results in increased expression of TRIM59 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 3:68,942,625...68,952,075
Ensembl chr 3:68,942,621...68,952,088
|
|
| G
|
Trim65
|
tripartite motif-containing 65
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of TRIM65 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr11:116,008,015...116,022,239
Ensembl chr11:116,012,672...116,021,954
|
|
| G
|
Trim67
|
tripartite motif-containing 67
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of TRIM67 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 8:125,519,758...125,561,443
Ensembl chr 8:125,519,831...125,561,452
|
|
| G
|
Trnt1
|
tRNA nucleotidyl transferase, CCA-adding, 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TRNT1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:106,746,099...106,759,435
Ensembl chr 6:106,746,081...106,759,435
|
|
| G
|
Trp53
|
transformation related protein 53
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of TP53 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of TP53 mRNA
|
CTD |
PMID:38568856 PMID:39276841 |
|
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
|
|
| G
|
Trp63
|
transformation related protein 63
|
increases expression
|
EXP
|
lead acetate results in increased expression of TRP63 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr16:25,502,513...25,710,842
Ensembl chr16:25,502,513...25,710,852
|
|
| G
|
Trpc1
|
transient receptor potential cation channel, subfamily C, member 1
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of TRPC1 mRNA lead acetate results in increased expression of TRPC1 mRNA; lead acetate results in increased expression of TRPC1 protein
|
CTD |
PMID:21829687 PMID:22674931 |
|
NCBI chr 9:95,587,125...95,632,438
Ensembl chr 9:95,587,135...95,632,428
|
|
| G
|
Trpc4
|
transient receptor potential cation channel, subfamily C, member 4
|
increases expression
|
ISO
|
lead acetate results in increased expression of TRPC4 mRNA; lead acetate results in increased expression of TRPC4 protein
|
CTD |
PMID:22674931 |
|
NCBI chr 3:54,063,441...54,225,892
Ensembl chr 3:54,063,456...54,225,892
|
|
| G
|
Trpc6
|
transient receptor potential cation channel, subfamily C, member 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of TRPC6 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 9:8,543,868...8,680,753
Ensembl chr 9:8,544,143...8,680,742
|
|
| G
|
Trpm1
|
transient receptor potential cation channel, subfamily M, member 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TRPM1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:63,803,583...63,923,630
Ensembl chr 7:63,803,583...63,919,523
|
|
| G
|
Trpv4
|
transient receptor potential cation channel, subfamily V, member 4
|
affects expression decreases expression
|
ISO
|
lead acetate affects the expression of TRPV4 mRNA lead acetate results in decreased expression of TRPV4 mRNA
|
CTD |
PMID:21864555 PMID:22641619 |
|
NCBI chr 5:114,760,213...114,796,497
Ensembl chr 5:114,760,213...114,796,482
|
|
| G
|
Trpv5
|
transient receptor potential cation channel, subfamily V, member 5
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which affects the expression of TRPV5 protein
|
CTD |
PMID:34350654 |
|
NCBI chr 6:41,628,595...41,658,158
Ensembl chr 6:41,629,107...41,657,703
|
|
| G
|
Try4
|
trypsin 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of PRSS3 mRNA; lead acetate results in increased expression of TRY4 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 6:41,279,206...41,282,467
Ensembl chr 6:41,279,203...41,282,466
|
|
| G
|
Try5
|
trypsin 5
|
increases expression
|
EXP
|
lead acetate results in increased expression of TRY5 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 6:41,288,166...41,291,644
Ensembl chr 6:41,288,167...41,293,775
|
|
| G
|
Tsc1
|
TSC complex subunit 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of TSC1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 2:28,531,005...28,581,183
Ensembl chr 2:28,531,240...28,581,179
|
|
| G
|
Tsc22d1
|
TSC22 domain family, member 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of TSC22D1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr14:76,652,401...76,745,205
Ensembl chr14:76,652,401...76,745,205
|
|
| G
|
Tsc22d3
|
TSC22 domain family, member 3
|
affects expression decreases expression increases expression
|
EXP ISO
|
lead acetate affects the expression of TSC22D3 mRNA lead acetate results in decreased expression of TSC22D3 mRNA lead acetate results in increased expression of TSC22D3 mRNA
|
CTD |
PMID:21829687 PMID:22641619 PMID:38568856 |
|
NCBI chr X:139,440,277...139,501,257
Ensembl chr X:139,440,277...139,501,408
|
|
| G
|
Tsg101
|
tumor susceptibility gene 101
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of TSG101 protein
|
CTD |
PMID:36840722 |
|
NCBI chr 7:46,538,693...46,569,716
Ensembl chr 7:46,538,697...46,569,717
|
|
| G
|
Tshb
|
thyroid stimulating hormone, beta subunit
|
multiple interactions decreases secretion decreases expression
|
ISO
|
lead acetate promotes the reaction [Zinc Oxide results in decreased secretion of TSHB protein]; Thyroxine inhibits the reaction [lead acetate results in decreased expression of TSHB protein]; Zinc Oxide promotes the reaction [lead acetate results in decreased secretion of TSHB protein]
|
CTD |
PMID:21871911 PMID:34553816 |
|
NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
|
|
| G
|
Tspan1
|
tetraspanin 1
|
decreases expression
|
EXP ISO
|
lead acetate results in decreased expression of TSPAN1 mRNA
|
CTD |
PMID:22609695 PMID:38568856 |
|
NCBI chr 4:116,019,078...116,024,818
Ensembl chr 4:116,019,066...116,024,798
|
|
| G
|
Tspan13
|
tetraspanin 13
|
increases expression
|
EXP
|
lead acetate results in increased expression of TSPAN13 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr12:36,064,554...36,092,477
Ensembl chr12:36,064,556...36,092,499
|
|
| G
|
Tspan2
|
tetraspanin 2
|
affects expression
|
ISO
|
lead acetate affects the expression of TSPAN2 protein
|
CTD |
PMID:36539177 |
|
NCBI chr 3:102,642,086...102,679,626
Ensembl chr 3:102,641,845...102,708,829
|
|
| G
|
Tspan32
|
tetraspanin 32
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of TSPAN32 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:142,558,644...142,573,223
Ensembl chr 7:142,558,783...142,573,381
|
|
| G
|
Tspan7
|
tetraspanin 7
|
increases expression
|
ISO
|
lead acetate results in increased expression of TSPAN7 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr X:10,351,355...10,462,843
Ensembl chr X:10,351,397...10,462,844
|
|
| G
|
Tsr2
|
TSR2 20S rRNA accumulation
|
increases expression
|
EXP
|
lead acetate results in increased expression of TSR2 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr X:149,870,090...149,879,539
Ensembl chr X:149,870,090...149,879,539
|
|
| G
|
Tst
|
thiosulfate sulfurtransferase, mitochondrial
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TST mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:78,283,756...78,290,065
Ensembl chr15:78,283,756...78,290,107
|
|
| G
|
Ttc13
|
tetratricopeptide repeat domain 13
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TTC13 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:125,398,066...125,448,748
Ensembl chr 8:125,398,071...125,448,722
|
|
| G
|
Ttc39d
|
tetratricopeptide repeat domain 39D
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of TTC39D mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr17:80,523,343...80,525,365
Ensembl chr17:80,514,889...80,525,365
|
|
| G
|
Ttc8
|
tetratricopeptide repeat domain 8
|
increases expression
|
EXP
|
lead acetate results in increased expression of TTC8 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr12:98,886,796...98,949,509
Ensembl chr12:98,886,833...98,949,497
|
|
| G
|
Tti1
|
TELO2 interacting protein 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of TTI1 protein
|
CTD |
PMID:38072110 |
|
NCBI chr 2:157,823,723...157,870,382
Ensembl chr 2:157,823,723...157,870,353
|
|
| G
|
Ttr
|
transthyretin
|
affects expression
|
ISO
|
lead acetate affects the expression of TTR protein
|
CTD |
PMID:36539177 |
|
NCBI chr18:20,797,266...20,807,383
Ensembl chr18:20,798,337...20,807,378
|
|
| G
|
Tuba1a
|
tubulin, alpha 1A
|
increases expression
|
ISO
|
lead acetate results in increased expression of TUBA1A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:98,847,728...98,851,382
Ensembl chr15:98,847,718...98,851,584
|
|
| G
|
Tuba4a
|
tubulin, alpha 4A
|
increases expression
|
ISO
|
lead acetate results in increased expression of TUBA4A mRNA
|
CTD |
PMID:37939567 PMID:38568856 |
|
NCBI chr 1:75,190,867...75,197,905
Ensembl chr 1:75,190,872...75,196,509
|
|
| G
|
Tubb2a
|
tubulin, beta 2A class IIA
|
increases expression
|
ISO
|
lead acetate results in increased expression of TUBB2A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr13:34,258,261...34,261,991
Ensembl chr13:34,258,257...34,261,990
|
|
| G
|
Tubb3
|
tubulin, beta 3 class III
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of TUBB3 mRNA PANX2 protein inhibits the reaction [lead acetate results in increased expression of TUBB3 mRNA]
|
CTD |
PMID:33862172 PMID:37939567 |
|
NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754
|
|
| G
|
Tubb6
|
tubulin, beta 6 class V
|
increases expression
|
EXP
|
lead acetate results in increased expression of TUBB6 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr18:67,523,801...67,535,819
Ensembl chr18:67,523,787...67,535,819
|
|
| G
|
Tulp1
|
TUB like protein 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of TULP1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr17:28,570,489...28,584,190
Ensembl chr17:28,570,489...28,584,196
|
|
| G
|
Tulp2
|
TUB like protein 2
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of TULP2 exon
|
CTD |
PMID:33445541 |
|
NCBI chr 7:45,131,450...45,173,070
Ensembl chr 7:45,131,301...45,173,056
|
|
| G
|
Txn1
|
thioredoxin 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of TXN mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
|
|
| G
|
Txndc8
|
thioredoxin domain containing 8
|
increases expression
|
EXP
|
lead acetate results in increased expression of TXNDC8 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:57,984,029...58,009,126
Ensembl chr 4:57,984,027...58,009,124
|
|
| G
|
Txnip
|
thioredoxin interacting protein
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of TXNIP mRNA [sodium arsenite co-treated with lead acetate] results in decreased expression of TXNIP protein
|
CTD |
PMID:22641619 PMID:38072110 PMID:38568856 |
|
NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199
|
|
| G
|
Txnrd1
|
thioredoxin reductase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of TXNRD1 mRNA; lead acetate results in increased expression of TXNRD1 protein
|
CTD |
PMID:24345272 PMID:27562236 PMID:37939567 PMID:38568856 |
|
NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
|
|
| G
|
Uba2
|
ubiquitin-like modifier activating enzyme 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of UBA2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:33,840,121...33,868,014
Ensembl chr 7:33,840,113...33,869,024
|
|
| G
|
Uba7
|
ubiquitin-like modifier activating enzyme 7
|
decreases expression increases expression
|
EXP
|
lead acetate results in decreased expression of UBA7 mRNA lead acetate results in increased expression of UBA7 mRNA
|
CTD |
PMID:22609695 PMID:22613225 |
|
NCBI chr 9:107,852,766...107,861,255
Ensembl chr 9:107,852,704...107,861,259
|
|
| G
|
Ubap1
|
ubiquitin-associated protein 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of UBAP1 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 4:41,348,996...41,389,766
Ensembl chr 4:41,348,996...41,390,525
|
|
| G
|
Ubash3b
|
ubiquitin associated and SH3 domain containing, B
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of UBASH3B mRNA lead acetate results in increased expression of UBASH3B mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr 9:40,922,056...41,069,358
Ensembl chr 9:40,922,394...41,072,993
|
|
| G
|
Ubc
|
ubiquitin C
|
decreases expression increases expression
|
EXP ISO
|
lead acetate results in decreased expression of UBC mRNA lead acetate results in increased expression of UBC mRNA
|
CTD |
PMID:21829687 PMID:38568856 |
|
NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266
|
|
| G
|
Ube2k
|
ubiquitin-conjugating enzyme E2K
|
affects expression
|
ISO
|
lead acetate affects the expression of UBE2K protein
|
CTD |
PMID:36539177 |
|
NCBI chr 5:65,694,588...65,756,332
Ensembl chr 5:65,694,576...65,756,331
|
|
| G
|
Ube2r2
|
ubiquitin-conjugating enzyme E2R 2
|
increases expression
|
ISO
|
lead acetate results in increased expression of UBE2R2 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 4:41,136,021...41,193,370
Ensembl chr 4:41,135,743...41,193,380
|
|
| G
|
Ube3d
|
ubiquitin protein ligase E3D
|
increases expression
|
EXP
|
lead acetate results in increased expression of UBE3D mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 9:86,189,364...86,347,003
Ensembl chr 9:86,189,359...86,347,003
|
|
| G
|
Ubfd1
|
ubiquitin family domain containing 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of UBFD1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:121,666,318...121,681,422
Ensembl chr 7:121,666,398...121,681,417
|
|
| G
|
Ubp1
|
upstream binding protein 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of UBP1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:113,760,002...113,807,095
Ensembl chr 9:113,760,002...113,806,270
|
|
| G
|
Ubr7
|
ubiquitin protein ligase E3 component n-recognin 7 (putative)
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of UBR7 protein
|
CTD |
PMID:38072110 |
|
NCBI chr12:102,724,234...102,743,960
Ensembl chr12:102,724,226...102,743,966
|
|
| G
|
Ubxn1
|
UBX domain protein 1
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of UBXN1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr19:8,848,912...8,853,030
Ensembl chr19:8,848,860...8,853,227
|
|
| G
|
Ubxn2a
|
UBX domain protein 2A
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of UBXN2A mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr12:4,926,814...4,957,749
Ensembl chr12:4,929,032...4,957,705
|
|
| G
|
Ubxn2b
|
UBX domain protein 2B
|
decreases expression multiple interactions
|
ISO
|
lead acetate results in decreased expression of UBXN2B mRNA [sodium arsenite co-treated with lead acetate] results in decreased expression of UBXN2B protein
|
CTD |
PMID:38072110 PMID:38568856 |
|
NCBI chr 4:6,191,105...6,219,788
Ensembl chr 4:6,191,098...6,221,688
|
|
| G
|
Ubxn6
|
UBX domain protein 6
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with lead acetate] results in decreased expression of UBXN6 protein
|
CTD |
PMID:38072110 |
|
NCBI chr17:56,374,045...56,386,333
Ensembl chr17:56,374,045...56,382,028
|
|
| G
|
Uevld
|
UEV and lactate/malate dehyrogenase domains
|
increases expression
|
EXP
|
lead acetate results in increased expression of UEVLD mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:46,572,964...46,608,275
Ensembl chr 7:46,572,964...46,608,275
|
|
| G
|
Ugdh
|
UDP-glucose dehydrogenase
|
increases expression
|
ISO
|
lead acetate results in increased expression of UGDH mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 5:65,570,550...65,593,185
Ensembl chr 5:65,570,564...65,593,292
|
|
| G
|
Ugt2a1
|
UDP glucuronosyltransferase 2 family, polypeptide A1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of UGT2A1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 5:87,607,349...87,638,730
Ensembl chr 5:87,607,349...87,638,730
|
|
| G
|
Ugt8a
|
UDP galactosyltransferase 8A
|
increases expression
|
ISO
|
lead acetate results in increased expression of UGT8 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 3:125,655,071...125,732,301
Ensembl chr 3:125,658,920...125,732,268
|
|
| G
|
Uhmk1
|
U2AF homology motif (UHM) kinase 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of UHMK1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:170,020,989...170,043,466
Ensembl chr 1:170,020,989...170,042,966
|
|
| G
|
Unc5cl
|
unc-5 family C-terminal like
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased methylation of UNC5CL 3' UTR; [lead acetate results in increased abundance of Lead] which results in increased methylation of UNC5CL exon; [lead acetate results in increased abundance of Lead] which results in increased methylation of UNC5CL intron
|
CTD |
PMID:33445541 |
|
NCBI chr17:48,761,155...48,846,737
Ensembl chr17:48,761,929...48,846,742
|
|
| G
|
Unc93b1
|
unc-93 homolog B1, TLR signaling regulator
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of UNC93B1 mRNA lead acetate results in decreased expression of UNC93B1 mRNA
|
CTD |
PMID:20542052 PMID:38568856 |
|
NCBI chr19:3,985,222...3,999,340
Ensembl chr19:3,985,186...3,999,340
|
|
| G
|
Unkl
|
unkempt family like zinc finger
|
increases expression
|
ISO
|
lead acetate results in increased expression of UNKL mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:25,407,336...25,453,417
Ensembl chr17:25,407,371...25,453,417
|
|
| G
|
Uqcrc1
|
ubiquinol-cytochrome c reductase core protein 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of UQCRC1 protein
|
CTD |
PMID:20797405 |
|
NCBI chr 9:108,765,716...108,778,709
Ensembl chr 9:108,765,701...108,778,691
|
|
| G
|
Uqcrc2
|
ubiquinol cytochrome c reductase core protein 2
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of UQCRC2 protein; BACH1 gene mutant form inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of UQCRC2 protein]
|
CTD |
PMID:36096218 |
|
NCBI chr 7:120,234,412...120,258,746
Ensembl chr 7:120,234,399...120,258,747
|
|
| G
|
Uqcrq
|
ubiquinol-cytochrome c reductase, complex III subunit VII
|
increases expression
|
ISO
|
lead acetate results in increased expression of UQCRQ mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr11:53,318,749...53,321,658
Ensembl chr11:53,318,749...53,321,658
|
|
| G
|
Uros
|
uroporphyrinogen III synthase
|
increases expression
|
ISO
|
lead acetate results in increased expression of UROS mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 7:133,287,871...133,312,176
Ensembl chr 7:133,287,972...133,311,801
|
|
| G
|
Usf1
|
upstream transcription factor 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of USF1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:171,238,881...171,246,327
Ensembl chr 1:171,238,881...171,246,710
|
|
| G
|
Usf2
|
upstream transcription factor 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of USF2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:30,645,421...30,656,288
Ensembl chr 7:30,644,673...30,656,228
|
|
| G
|
Usp13
|
ubiquitin specific peptidase 13 (isopeptidase T-3)
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of USP13 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 3:32,870,432...32,992,224
Ensembl chr 3:32,871,695...32,992,220
|
|
| G
|
Usp18
|
ubiquitin specific peptidase 18
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of USP18 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876
|
|
| G
|
Usp31
|
ubiquitin specific peptidase 31
|
increases methylation
|
ISO
|
lead acetate results in increased methylation of USP31 gene
|
CTD |
PMID:29571894 |
|
NCBI chr 7:121,241,244...121,306,683
Ensembl chr 7:121,241,244...121,306,476
|
|
| G
|
Usp34
|
ubiquitin specific peptidase 34
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of USP34 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr11:23,256,433...23,440,560
Ensembl chr11:23,256,895...23,440,560
|
|
| G
|
Usp40
|
ubiquitin specific peptidase 40
|
increases expression
|
EXP
|
lead acetate results in increased expression of USP40 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:87,872,841...87,936,308
Ensembl chr 1:87,872,841...87,936,273
|
|
| G
|
Usp42
|
ubiquitin specific peptidase 42
|
increases expression
|
EXP
|
lead acetate results in increased expression of USP42 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 5:143,696,077...143,741,600
Ensembl chr 5:143,696,080...143,718,035
|
|
| G
|
Usp6nl
|
USP6 N-terminal like
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of USP6NL mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 2:6,327,444...6,453,107
Ensembl chr 2:6,327,478...6,451,201
|
|
| G
|
Uspl1
|
ubiquitin specific peptidase like 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of USPL1 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:149,121,338...149,152,246
Ensembl chr 5:149,121,160...149,152,244
|
|
| G
|
Uxs1
|
UDP-glucuronate decarboxylase 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of UXS1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:43,786,121...43,866,999
Ensembl chr 1:43,786,126...43,866,960
|
|
| G
|
V1rd19
|
vomeronasal 1 receptor, D19
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of V1RD19 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:23,702,536...23,703,453
Ensembl chr 7:23,701,116...23,704,482
|
|
| G
|
Vamp1
|
vesicle-associated membrane protein 1
|
increases expression decreases expression
|
EXP ISO
|
lead acetate results in increased expression of VAMP1 mRNA lead acetate results in decreased expression of VAMP1 mRNA
|
CTD |
PMID:24260418 PMID:27984133 |
|
NCBI chr 6:125,192,544...125,199,269
Ensembl chr 6:125,192,514...125,222,927
|
|
| G
|
Vamp2
|
vesicle-associated membrane protein 2
|
multiple interactions affects expression affects localization decreases expression
|
ISO EXP
|
2,2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [lead acetate affects the localization of VAMP2 protein]; [[lead acetate results in increased abundance of Lead] which results in increased expression of MIR34B mRNA] which results in decreased expression of VAMP2 protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of VAMP2 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of VAMP2 protein; BDNF protein inhibits the reaction [lead acetate results in decreased expression of VAMP2 protein] lead acetate affects the expression of VAMP2 mRNA
|
CTD |
PMID:20375082 PMID:22265330 PMID:27984133 PMID:35367965 |
|
NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210
|
|
| G
|
Vamp5
|
vesicle-associated membrane protein 5
|
increases expression
|
ISO
|
lead acetate results in increased expression of VAMP5 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 6:72,345,032...72,357,451
Ensembl chr 6:72,345,777...72,357,451
|
|
| G
|
Vapa
|
vesicle-associated membrane protein, associated protein A
|
decreases expression multiple interactions
|
EXP ISO
|
lead acetate results in decreased expression of VAPA mRNA lead acetate results in decreased expression of VAPA protein sodium arsenite promotes the reaction [lead acetate results in decreased expression of VAPA protein]
|
CTD |
PMID:21829687 PMID:38072110 |
|
NCBI chr17:65,887,048...65,925,441
Ensembl chr17:65,885,322...65,920,550
|
|
| G
|
Vasp
|
vasodilator-stimulated phosphoprotein
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of VASP mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:18,990,854...19,005,779
Ensembl chr 7:18,990,854...19,005,742
|
|
| G
|
Vat1l
|
vesicle amine transport protein 1 like
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of VAT1L mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:114,932,307...115,100,814
Ensembl chr 8:114,932,352...115,100,811
|
|
| G
|
Vav3
|
vav 3 oncogene
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of VAV3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 3:109,247,757...109,593,010
Ensembl chr 3:109,247,969...109,593,014
|
|
| G
|
Vdac1
|
voltage-dependent anion channel 1
|
decreases expression
|
ISO EXP
|
lead acetate results in decreased expression of VDAC1 protein lead acetate results in decreased expression of VDAC1 mRNA; lead acetate results in decreased expression of VDAC1 protein
|
CTD |
PMID:19822599 PMID:20797405 |
|
NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224
|
|
| G
|
Vdr
|
vitamin D (1,25-dihydroxyvitamin D3) receptor
|
multiple interactions
|
ISO
|
lead acetate promotes the reaction [VDR protein binds to NCOA2 protein]
|
CTD |
PMID:21229763 |
|
NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
|
|
| G
|
Vegfa
|
vascular endothelial growth factor A
|
increases expression
|
ISO
|
lead acetate results in increased expression of VEGFA mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
|
|
| G
|
Vegfc
|
vascular endothelial growth factor C
|
increases expression
|
ISO
|
lead acetate results in increased expression of VEGFC mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 8:54,530,567...54,639,489
Ensembl chr 8:54,530,641...54,640,131
|
|
| G
|
Vgf
|
VGF nerve growth factor inducible
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of VGF mRNA [sodium arsenite co-treated with lead acetate] results in increased expression of VGF protein
|
CTD |
PMID:27562236 PMID:38072110 |
|
NCBI chr 5:137,054,156...137,062,205
Ensembl chr 5:137,055,246...137,062,205
|
|
| G
|
Vgll3
|
vestigial like family member 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of VGLL3 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr16:65,612,075...65,663,254
Ensembl chr16:65,612,143...65,663,254
|
|
| G
|
Vim
|
vimentin
|
multiple interactions affects expression
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of VIM mRNA lead acetate affects the expression of VIM protein [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of VIM protein; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of VIM mRNA]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of VIM protein]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of VIM mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of VIM protein]
|
CTD |
PMID:12634122 PMID:36539177 PMID:39722890 |
|
NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
|
|
| G
|
Vldlr
|
very low density lipoprotein receptor
|
increases expression
|
EXP
|
lead acetate results in increased expression of VLDLR mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr19:27,190,070...27,231,631
Ensembl chr19:27,193,884...27,231,631
|
|
| G
|
Vmn1r43
|
vomeronasal 1 receptor 43
|
increases expression
|
EXP
|
lead acetate results in increased expression of VMN1R43 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 6:89,846,443...89,847,511
Ensembl chr 6:89,835,916...89,853,395
|
|
| G
|
Vmn1r55
|
vomeronasal 1 receptor 55
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of VMN1R55 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr 7:5,149,489...5,150,421
Ensembl chr 7:5,132,290...5,152,669
|
|
| G
|
Vmn1r80
|
vomeronasal 1 receptor 80
|
increases expression
|
EXP
|
lead acetate results in increased expression of VMN1R80 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:11,926,892...11,927,818
Ensembl chr 7:11,923,213...11,937,240
|
|
| G
|
Vmn2r104
|
vomeronasal 2, receptor 104
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of VMN2R104 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr17:20,249,687...20,268,467
Ensembl chr17:20,248,680...20,268,598
|
|
| G
|
Vmn2r122
|
vomeronasal 2, receptor, 122
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of VMN2R122 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:156,554,341...156,562,726
|
|
| G
|
Vps33a
|
VPS33A CORVET/HOPS core subunit
|
increases expression affects expression multiple interactions
|
EXP ISO
|
lead acetate results in increased expression of VPS33A mRNA lead acetate affects the expression of VPS33A protein [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of VPS33A mRNA
|
CTD |
PMID:20542052 PMID:22839698 PMID:36539177 |
|
NCBI chr 5:123,666,820...123,711,104
Ensembl chr 5:123,666,722...123,711,101
|
|
| G
|
Vps36
|
vacuolar protein sorting 36
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of VPS36 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 8:22,682,849...22,710,969
Ensembl chr 8:22,682,825...22,710,859
|
|
| G
|
Vstm2l
|
V-set and transmembrane domain containing 2-like
|
increases expression
|
ISO
|
lead acetate results in increased expression of VSTM2L mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 2:157,756,573...157,786,639
Ensembl chr 2:157,756,573...157,786,639
|
|
| G
|
Vsx2
|
visual system homeobox 2
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which affects the expression of VSX2 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of VSX2 mRNA
|
CTD |
PMID:28050121 |
|
NCBI chr12:84,616,602...84,642,231
Ensembl chr12:84,616,536...84,642,231
|
|
| G
|
Vwa3b
|
von Willebrand factor A domain containing 3B
|
affects expression
|
ISO
|
lead acetate affects the expression of VWA3B mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 1:37,068,372...37,226,689
Ensembl chr 1:37,065,677...37,226,694
|
|
| G
|
Vwc2l
|
von Willebrand factor C domain-containing protein 2-like
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of VWC2L mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr 1:70,764,471...70,928,097
Ensembl chr 1:70,764,874...70,924,556
|
|
| G
|
Wars1
|
tryptophanyl-tRNA synthetase1
|
increases expression
|
ISO
|
lead acetate results in increased expression of WARS1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr12:108,825,956...108,860,095
Ensembl chr12:108,825,956...108,860,100
|
|
| G
|
Wasf2
|
WASP family, member 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of WASF2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 4:132,857,843...132,927,067
Ensembl chr 4:132,857,816...132,927,067
|
|
| G
|
Wdr35
|
WD repeat domain 35
|
increases expression
|
EXP
|
lead acetate results in increased expression of WDR35 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr12:9,023,897...9,078,848
Ensembl chr12:9,023,892...9,078,847
|
|
| G
|
Wdr86
|
WD repeat domain 86
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of WDR86 mRNA
|
CTD |
PMID:37939567 |
|
NCBI chr 5:24,901,898...24,935,696
Ensembl chr 5:24,916,736...24,935,725
|
|
| G
|
Wfdc18
|
WAP four-disulfide core domain 18
|
increases expression
|
EXP
|
lead acetate results in increased expression of WFDC18 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr11:83,599,830...83,602,186
Ensembl chr11:83,599,841...83,602,174
|
|
| G
|
Wipi1
|
WD repeat domain, phosphoinositide interacting 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of WIPI1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:109,464,347...109,502,215
Ensembl chr11:109,464,157...109,502,793
|
|
| G
|
Wnt1
|
wingless-type MMTV integration site family, member 1
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT1 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr15:98,687,738...98,691,711
Ensembl chr15:98,687,738...98,691,718
|
|
| G
|
Wnt11
|
wingless-type MMTV integration site family, member 11
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of WNT11 mRNA]; [lead acetate results in increased abundance of Lead] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of WNT11 protein]
|
CTD |
PMID:38157908 |
|
NCBI chr 7:98,484,293...98,503,954
Ensembl chr 7:98,484,319...98,504,402
|
|
| G
|
Wnt2
|
wingless-type MMTV integration site family, member 2
|
multiple interactions
|
ISO
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT2 mRNA
|
CTD |
PMID:12634122 |
|
NCBI chr 6:17,988,939...18,032,771
Ensembl chr 6:17,988,939...18,030,584
|
|
| G
|
Wnt3a
|
wingless-type MMTV integration site family, member 3A
|
multiple interactions
|
EXP
|
[[lead acetate results in increased abundance of Lead] which results in decreased expression of PORCN protein] which results in decreased localization of WNT3A protein; [lead acetate results in increased abundance of Lead] which results in decreased localization of WNT3A protein; [lead acetate results in increased abundance of Lead] which results in increased expression of WNT3A mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of WNT3A protein
|
CTD |
PMID:37436718 |
|
NCBI chr11:59,138,859...59,181,579
Ensembl chr11:59,138,859...59,181,578
|
|
| G
|
Wnt5a
|
wingless-type MMTV integration site family, member 5A
|
increases expression
|
ISO
|
lead acetate results in increased expression of WNT5A mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr14:28,224,962...28,249,405
Ensembl chr14:28,226,707...28,249,405
|
|
| G
|
Wnt7a
|
wingless-type MMTV integration site family, member 7A
|
multiple interactions increases expression decreases expression
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of WNT7A mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of WNT7A protein; asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of WNT7A mRNA]; asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of WNT7A protein] lead acetate results in increased expression of WNT7A mRNA WNT7A protein inhibits the reaction [lead acetate results in increased phosphorylation of CTNNB1 protein] lead acetate results in decreased expression of WNT7A protein
|
CTD |
PMID:11578147 PMID:24999626 PMID:27936013 |
|
NCBI chr 6:91,340,963...91,388,335
Ensembl chr 6:91,340,963...91,388,345
|
|
| G
|
Wnt8a
|
wingless-type MMTV integration site family, member 8A
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of WNT8A mRNA]
|
CTD |
PMID:38157908 |
|
NCBI chr18:34,675,380...34,681,114
Ensembl chr18:34,675,366...34,681,326
|
|
| G
|
Wnt9a
|
wingless-type MMTV integration site family, member 9A
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of WNT9A mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr11:59,197,675...59,224,378
Ensembl chr11:59,197,754...59,224,378
|
|
| G
|
Wsb2
|
WD repeat and SOCS box-containing 2
|
increases expression multiple interactions
|
ISO
|
lead acetate results in increased expression of WSB2 mRNA [lead acetate co-treated with zinc protoporphyrin] results in decreased expression of WSB2 mRNA
|
CTD |
PMID:22839698 PMID:38568856 |
|
NCBI chr 5:117,495,370...117,516,666
Ensembl chr 5:117,495,369...117,516,666
|
|
| G
|
Wwp1
|
WW domain containing E3 ubiquitin protein ligase 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of WWP1 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 4:19,608,296...19,709,004
Ensembl chr 4:19,608,303...19,708,993
|
|
| G
|
Xaf1
|
XIAP associated factor 1
|
increases expression
|
EXP
|
lead acetate results in increased expression of XAF1 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr11:72,192,229...72,204,560
Ensembl chr11:72,192,455...72,204,559
|
|
| G
|
Xbp1
|
X-box binding protein 1
|
multiple interactions increases expression
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of XBP1 mRNA lead acetate results in increased expression of XBP1 mRNA
|
CTD |
PMID:36642386 PMID:38568856 |
|
NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
|
|
| G
|
Xiap
|
X-linked inhibitor of apoptosis
|
multiple interactions
|
ISO EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of XIAP mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of XIAP protein; MIR106B mRNA affects the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of XIAP protein]
|
CTD |
PMID:32344020 |
|
NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533
|
|
| G
|
Xpa
|
xeroderma pigmentosum, complementation group A
|
increases expression
|
EXP
|
lead acetate results in increased expression of XPA mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:46,175,222...46,196,317
Ensembl chr 4:46,155,347...46,196,311
|
|
| G
|
Xpot
|
exportin, tRNA (nuclear export receptor for tRNAs)
|
increases expression
|
ISO
|
lead acetate results in increased expression of XPOT mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr10:121,423,285...121,462,411
Ensembl chr10:121,423,285...121,462,237
|
|
| G
|
Yap1
|
yes-associated protein 1
|
affects expression
|
ISO
|
lead acetate affects the expression of YAP1 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 9:7,932,000...8,004,890
Ensembl chr 9:7,932,000...8,004,597
|
|
| G
|
Yars1
|
tyrosyl-tRNA synthetase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of YARS1 mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 4:129,083,595...129,113,033
Ensembl chr 4:129,083,553...129,113,400
|
|
| G
|
Yif1a
|
Yip1 interacting factor homolog A (S. cerevisiae)
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of YIF1A mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr19:5,138,566...5,142,907
Ensembl chr19:5,138,566...5,142,909
|
|
| G
|
Yipf5
|
Yip1 domain family, member 5
|
increases expression
|
ISO
|
lead acetate results in increased expression of YIPF5 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr18:40,337,918...40,352,452
Ensembl chr18:40,336,949...40,352,482
|
|
| G
|
Ypel3
|
yippee like 3
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of YPEL3 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:126,376,135...126,379,682
Ensembl chr 7:126,376,127...126,379,686
|
|
| G
|
Yy1
|
YY1 transcription factor
|
decreases methylation
|
ISO
|
lead acetate results in decreased methylation of YY1 gene
|
CTD |
PMID:29571894 |
|
NCBI chr12:108,758,841...108,786,074
Ensembl chr12:108,758,899...108,786,074
|
|
| G
|
Zap70
|
zeta-chain (TCR) associated protein kinase
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ZAP70 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899
|
|
| G
|
Zbtb32
|
zinc finger and BTB domain containing 32
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZBTB32 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:30,289,105...30,302,244
Ensembl chr 7:30,289,106...30,298,334
|
|
| G
|
Zc3h3
|
zinc finger CCCH type containing 3
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZC3H3 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr15:75,626,279...75,713,772
Ensembl chr15:75,626,279...75,713,764
|
|
| G
|
Zcchc2
|
zinc finger, CCHC domain containing 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZCCHC2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 1:105,916,929...105,961,807
Ensembl chr 1:105,918,136...105,961,804
|
|
| G
|
Zcchc8
|
zinc finger, CCHC domain containing 8
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ZCCHC8 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 5:123,836,365...123,859,107
Ensembl chr 5:123,836,357...123,859,163
|
|
| G
|
Zcrb1
|
zinc finger CCHC-type and RNA binding motif 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of ZCRB1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr15:93,283,987...93,296,218
Ensembl chr15:93,283,978...93,296,215
|
|
| G
|
Zdhhc14
|
zinc finger, DHHC domain containing 14
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of ZDHHC14 intron
|
CTD |
PMID:33445541 |
|
NCBI chr17:5,542,220...5,810,517
Ensembl chr17:5,542,832...5,804,086
|
|
| G
|
Zdhhc9
|
zinc finger, DHHC domain containing 9
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ZDHHC9 mRNA
|
CTD |
PMID:22613225 |
|
NCBI chr X:47,260,844...47,297,792
Ensembl chr X:47,260,846...47,297,755
|
|
| G
|
Zeb1
|
zinc finger E-box binding homeobox 1
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ZEB1 mRNA; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ZEB1 protein; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ZEB1 mRNA]; CAT inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ZEB1 protein]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ZEB1 mRNA]; GCLC inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of ZEB1 protein]
|
CTD |
PMID:39276841 PMID:39722890 |
|
NCBI chr18:5,591,330...5,775,468
Ensembl chr18:5,591,860...5,775,467
|
|
| G
|
Zfand6
|
zinc finger, AN1-type domain 6
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZFAND6 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:84,264,253...84,339,224
Ensembl chr 7:84,262,974...84,339,167
|
|
| G
|
Zfp185
|
zinc finger protein 185
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ZFP185 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr X:72,030,860...72,075,149
Ensembl chr X:72,030,945...72,075,149
|
|
| G
|
Zfp263
|
zinc finger protein 263
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZFP263 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr16:3,561,883...3,568,654
Ensembl chr16:3,561,957...3,568,654
|
|
| G
|
Zfp330
|
zinc finger protein 330
|
increases expression
|
EXP ISO
|
lead acetate results in increased expression of ZFP330 mRNA lead acetate results in increased expression of ZNF330 mRNA
|
CTD |
PMID:25270620 PMID:38568856 |
|
NCBI chr 8:83,490,247...83,500,774
Ensembl chr 8:83,490,236...83,500,789
|
|
| G
|
Zfp352
|
zinc finger protein 352
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZFP352 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 4:90,107,057...90,113,924
Ensembl chr 4:90,107,057...90,113,939
|
|
| G
|
Zfp36
|
zinc finger protein 36
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZFP36 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 7:28,076,208...28,078,680
Ensembl chr 7:28,076,209...28,079,678
|
|
| G
|
Zfp36l1
|
zinc finger protein 36, C3H type-like 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of ZFP36L1 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr12:80,154,534...80,159,787
Ensembl chr12:80,154,528...80,159,787
|
|
| G
|
Zfp36l2
|
zinc finger protein 36, C3H type-like 2
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZFP36L2 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr17:84,491,352...84,495,375
Ensembl chr17:84,491,359...84,495,375
|
|
| G
|
Zfp42
|
zinc finger protein 42
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZFP42 mRNA
|
CTD |
PMID:31715224 |
|
NCBI chr 8:43,748,100...43,760,041
Ensembl chr 8:43,748,100...43,760,017
|
|
| G
|
Zfp426
|
zinc finger protein 426
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZFP426 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:20,379,845...20,404,042
Ensembl chr 9:20,379,845...20,404,042
|
|
| G
|
Zfp467
|
zinc finger protein 467
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ZNF467 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:48,404,626...48,422,926
Ensembl chr 6:48,404,631...48,422,759
|
|
| G
|
Zfp507
|
zinc finger protein 507
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZFP507 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:35,471,768...35,502,749
Ensembl chr 7:35,471,768...35,502,428
|
|
| G
|
Zfp560
|
zinc finger protein 560
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ZFP560 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 9:20,256,432...20,296,479
Ensembl chr 9:20,256,432...20,296,473
|
|
| G
|
Zfp59
|
zinc finger protein 59
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZFP59 mRNA
|
CTD |
PMID:21829687 |
|
NCBI chr 7:27,535,471...27,556,218
Ensembl chr 7:27,538,032...27,555,863
|
|
| G
|
Zfp598
|
zinc finger protein 598
|
increases expression
|
ISO
|
lead acetate results in increased expression of ZNF598 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr17:24,888,661...24,900,997
Ensembl chr17:24,888,661...24,900,990
|
|
| G
|
Zfp655
|
zinc finger protein 655
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZFP655 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr 5:145,168,503...145,184,116
Ensembl chr 5:145,168,525...145,213,723
|
|
| G
|
Zfp692
|
zinc finger protein 692
|
decreases expression
|
ISO
|
lead acetate results in decreased expression of ZNF692 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr11:58,197,883...58,205,971
Ensembl chr11:58,197,895...58,205,453
|
|
| G
|
Zfp746
|
zinc finger protein 746
|
increases expression
|
ISO
|
lead acetate results in increased expression of ZNF746 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:48,039,325...48,064,275
Ensembl chr 6:48,039,329...48,063,527
|
|
| G
|
Zfp768
|
zinc finger protein 768
|
increases expression
|
ISO
|
lead acetate results in increased expression of ZNF768 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:126,941,967...126,944,486
Ensembl chr 7:126,941,967...126,944,761
|
|
| G
|
Zfp771
|
zinc finger protein 771
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZFP771 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:126,842,168...126,854,044
Ensembl chr 7:126,843,446...126,853,975
|
|
| G
|
Zfp787
|
zinc finger protein 787
|
increases expression
|
ISO
|
lead acetate results in increased expression of ZNF787 mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 7:6,134,488...6,162,382
Ensembl chr 7:6,134,490...6,158,996
|
|
| G
|
Zfp827
|
zinc finger protein 827
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in increased expression of ZNF827 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr 8:79,753,754...79,920,397
Ensembl chr 8:79,755,066...79,920,395
|
|
| G
|
Zfp930
|
zinc finger protein 930
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ZFP930 mRNA
|
CTD |
PMID:20542052 |
|
NCBI chr 8:69,661,701...69,683,188
Ensembl chr 8:69,661,690...69,683,188
|
|
| G
|
Zfyve16
|
zinc finger, FYVE domain containing 16
|
multiple interactions
|
ISO
|
[lead acetate co-treated with zinc protoporphyrin] results in decreased expression of ZFYVE16 mRNA
|
CTD |
PMID:22839698 |
|
NCBI chr13:92,624,257...92,667,318
Ensembl chr13:92,623,616...92,667,376
|
|
| G
|
Zic4
|
zinc finger protein of the cerebellum 4
|
increases expression
|
EXP
|
lead acetate results in increased expression of ZIC4 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 9:91,247,636...91,271,404
Ensembl chr 9:91,244,466...91,271,401
|
|
| G
|
Zim1
|
zinc finger, imprinted 1
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ZIM1 mRNA
|
CTD |
PMID:22609695 |
|
NCBI chr 7:6,677,443...6,699,521
Ensembl chr 7:6,674,268...6,699,449
|
|
| G
|
Zmynd10
|
zinc finger, MYND domain containing 10
|
affects expression
|
ISO
|
lead acetate affects the expression of ZMYND10 mRNA
|
CTD |
PMID:21864555 |
|
NCBI chr 9:107,424,067...107,428,520
Ensembl chr 9:107,424,497...107,428,518
|
|
| G
|
Znrd2
|
zinc ribbon domain containing 2
|
decreases expression
|
EXP
|
lead acetate results in decreased expression of ZNRD2 mRNA
|
CTD |
PMID:25270620 |
|
NCBI chr19:5,780,334...5,781,760
Ensembl chr19:5,780,331...5,781,760 Ensembl chr19:5,780,331...5,781,760
|
|
| G
|
Zup1
|
zinc finger containing ubiquitin peptidase 1
|
increases expression
|
ISO
|
lead acetate results in increased expression of ZUP1 mRNA
|
CTD |
PMID:22641619 |
|
NCBI chr10:33,795,138...33,827,316
Ensembl chr10:33,795,138...33,827,265
|
|
| G
|
Zyg11a
|
zyg-11 family member A, cell cycle regulator
|
increases expression
|
ISO
|
lead acetate results in increased expression of EIF3CL mRNA
|
CTD |
PMID:11578147 |
|
NCBI chr 4:108,037,442...108,075,285
Ensembl chr 4:108,038,935...108,075,245
|
|
| G
|
Zyx
|
zyxin
|
increases expression
|
ISO
|
lead acetate results in increased expression of ZYX mRNA
|
CTD |
PMID:38568856 |
|
NCBI chr 6:42,326,507...42,337,158
Ensembl chr 6:42,326,564...42,337,147
|
|
|
|
| G
|
Hmbs
|
hydroxymethylbilane synthase
|
decreases activity
|
ISO
|
Lead ion decreases activity of purified Hmbs protein
|
RGD |
PMID:6732900 |
RGD:25394584 |
NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525
|
|
|
|
| G
|
Aco1
|
aconitase 1
|
decreases expression multiple interactions
|
ISO
|
lead nitrate results in decreased expression of ACO1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in decreased expression of ACO1 protein]
|
CTD |
PMID:22502979 |
|
NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338
|
|
| G
|
Acta1
|
actin alpha 1, skeletal muscle
|
increases expression
|
EXP
|
lead nitrate results in increased expression of ACTA1 protein
|
CTD |
PMID:20435106 |
|
NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490
|
|
| G
|
Ahr
|
aryl-hydrocarbon receptor
|
increases expression multiple interactions
|
ISO
|
lead nitrate results in increased expression of AHR mRNA; lead nitrate results in increased expression of AHR protein AHR promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; AHR promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]
|
CTD |
PMID:31682781 |
|
NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
|
|
| G
|
Ahsg
|
alpha-2-HS-glycoprotein
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of AHSG mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr16:22,710,793...22,718,193
Ensembl chr16:22,710,027...22,718,199
|
|
| G
|
Akap3
|
A kinase anchor protein 3
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of AKAP3 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 6:126,830,061...126,851,271
Ensembl chr 6:126,830,061...126,851,271
|
|
| G
|
Alad
|
aminolevulinate, delta-, dehydratase
|
decreases activity multiple interactions
|
ISO
|
lead nitrate results in decreased activity of ALAD protein lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]
|
CTD |
PMID:2061546 |
|
NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155
|
|
| G
|
Alb
|
albumin
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead nitrate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with chromium trioxide co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein
|
CTD |
PMID:39414706 |
|
NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
|
|
| G
|
Alpl
|
alkaline phosphatase, liver/bone/kidney
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead nitrate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with chromium trioxide co-treated with manganese chloride co-treated with ferric chloride] results in increased expression of ALPL protein
|
CTD |
PMID:39414706 |
|
NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
|
|
| G
|
Apaf1
|
apoptotic peptidase activating factor 1
|
decreases expression multiple interactions
|
EXP
|
lead nitrate results in decreased expression of APAF1 protein mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein]
|
CTD |
PMID:23451106 |
|
NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632
|
|
| G
|
Arhgdib
|
Rho, GDP dissociation inhibitor beta
|
increases expression
|
EXP
|
lead nitrate results in increased expression of ARHGDIB protein
|
CTD |
PMID:20435106 |
|
NCBI chr 6:136,900,653...136,918,895
Ensembl chr 6:136,900,653...136,918,897
|
|
| G
|
Arrdc5
|
arrestin domain containing 5
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of ARRDC5 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr17:56,601,111...56,607,262
Ensembl chr17:56,601,111...56,607,286
|
|
| G
|
Azin2
|
antizyme inhibitor 2
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of AZIN2 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 4:128,824,026...128,856,250
Ensembl chr 4:128,824,026...128,856,235
|
|
| G
|
Bax
|
BCL2-associated X protein
|
multiple interactions increases expression
|
EXP ISO
|
mangiferin inhibits the reaction [lead nitrate results in increased expression of BAX protein] [lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of BAX mRNA]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA]
|
CTD |
PMID:23451106 PMID:30738203 |
|
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
|
|
| G
|
Bcl2
|
B cell leukemia/lymphoma 2
|
decreases expression multiple interactions
|
EXP ISO
|
lead nitrate results in decreased expression of BCL2 protein [lead nitrate results in increased abundance of Lead] which results in decreased expression of BCL2 mRNA mangiferin inhibits the reaction [lead nitrate results in decreased expression of BCL2 protein]
|
CTD |
PMID:23451106 PMID:30738203 |
|
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
|
|
| G
|
Cadm3
|
cell adhesion molecule 3
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of CADM3 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 1:173,161,825...173,195,214
Ensembl chr 1:173,160,825...173,195,261
|
|
| G
|
Car9
|
carbonic anhydrase 9
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of CA9 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729
|
|
| G
|
Casp14
|
caspase 14
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of CASP14 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr10:78,547,829...78,554,181
Ensembl chr10:78,547,825...78,554,128
|
|
| G
|
Casp3
|
caspase 3
|
multiple interactions increases expression increases activity
|
ISO EXP
|
[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP3 protein; [lead nitrate results in increased abundance of Lead] which results in increased expression of CASP3 mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP3 protein]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of CASP3 mRNA] lead nitrate results in increased expression of CASP3 protein puerarin inhibits the reaction [lead nitrate results in increased activity of CASP3 protein] [sodium arsenite co-treated with Cadmium Chloride co-treated with lead nitrate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with chromium trioxide co-treated with manganese chloride co-treated with ferric chloride] results in increased expression of CASP3 protein; mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP3 protein]
|
CTD |
PMID:23451106 PMID:24505050 PMID:30738203 PMID:39414706 |
|
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
|
|
| G
|
Casp6
|
caspase 6
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead nitrate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with chromium trioxide co-treated with manganese chloride co-treated with ferric chloride] results in increased expression of CASP6 protein
|
CTD |
PMID:39414706 |
|
NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752
|
|
| G
|
Casp7
|
caspase 7
|
multiple interactions decreases expression
|
EXP
|
lead nitrate affects the reaction [CASP7 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CASP7 affects the expression of MT2 mRNA] lead nitrate results in decreased expression of CASP7 mRNA
|
CTD |
PMID:11891201 |
|
NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
|
|
| G
|
Casp8
|
caspase 8
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead nitrate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with chromium trioxide co-treated with manganese chloride co-treated with ferric chloride] results in increased expression of CASP8 protein
|
CTD |
PMID:39414706 |
|
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
|
|
| G
|
Casp9
|
caspase 9
|
multiple interactions increases expression
|
EXP ISO
|
mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP9 protein] [lead nitrate results in increased abundance of Lead] which results in increased activity of CASP9 protein; [lead nitrate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP9 protein]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA]
|
CTD |
PMID:23451106 PMID:30738203 |
|
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
|
|
| G
|
Cat
|
catalase
|
decreases activity multiple interactions
|
EXP ISO
|
lead nitrate results in decreased activity of CAT protein [lead nitrate results in increased abundance of Lead] which results in decreased activity of CAT protein; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased activity of CAT protein] Ashwagandha inhibits the reaction [lead nitrate results in decreased activity of CAT protein]; puerarin inhibits the reaction [lead nitrate results in decreased activity of CAT protein] mangiferin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]
|
CTD |
PMID:23315276 PMID:23451106 PMID:24987671 PMID:30738203 |
|
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
|
|
| G
|
Ccl20
|
C-C motif chemokine ligand 20
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of CCL20 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
|
|
| G
|
Ccng1
|
cyclin G1
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [CCNG1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138
|
|
| G
|
Cd86
|
CD86 antigen
|
increases expression
|
EXP
|
lead nitrate results in increased expression of CD86 protein
|
CTD |
PMID:23376802 |
|
NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
|
|
| G
|
Cdyl
|
chromodomain protein, Y chromosome-like
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of CDYL mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr13:35,843,801...36,058,047
Ensembl chr13:35,843,816...36,058,046
|
|
| G
|
Chuk
|
conserved helix-loop-helix ubiquitous kinase
|
increases phosphorylation multiple interactions
|
EXP
|
lead nitrate results in increased phosphorylation of CHUK protein mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of CHUK protein]
|
CTD |
PMID:23451106 |
|
NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
|
|
| G
|
Cox8c
|
cytochrome c oxidase subunit 8C
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of COX8C mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr12:102,865,565...102,866,793
Ensembl chr12:102,865,575...102,866,785
|
|
| G
|
Cps1
|
carbamoyl-phosphate synthetase 1
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of CPS1 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 1:67,151,294...67,270,426
Ensembl chr 1:67,162,185...67,270,418
|
|
| G
|
Crisp2
|
cysteine-rich secretory protein 2
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of CRISP2 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr17:41,075,625...41,105,037
Ensembl chr17:41,074,911...41,117,894
|
|
| G
|
Crp
|
C-reactive protein, pentraxin-related
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of CRP mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
|
|
| G
|
Cryaa
|
crystallin, alpha A
|
affects metabolic processing
|
ISO
|
lead nitrate affects the metabolism of CRYAA protein
|
CTD |
PMID:21139692 |
|
NCBI chr17:31,896,905...31,900,704
Ensembl chr17:31,896,781...31,900,707
|
|
| G
|
Cryab
|
crystallin, alpha B
|
affects metabolic processing
|
ISO
|
lead nitrate affects the metabolism of CRYAB protein
|
CTD |
PMID:21139692 |
|
NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936
|
|
| G
|
Cst8
|
cystatin 8 (cystatin-related epididymal spermatogenic)
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of CST8 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 2:148,640,759...148,647,516
Ensembl chr 2:148,640,705...148,647,515
|
|
| G
|
Ctnna1
|
catenin alpha 1
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [CTNNA1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr18:35,251,955...35,387,829
Ensembl chr18:35,251,912...35,387,832
|
|
| G
|
Ctnnb1
|
catenin beta 1
|
multiple interactions
|
EXP ISO
|
[lead nitrate results in increased abundance of Lead] which results in decreased expression of and affects the localization of CTNNB1 protein; [lead nitrate results in increased abundance of Lead] which results in decreased expression of CTNNB1 mRNA; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of and affects the localization of CTNNB1 protein]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of CTNNB1 mRNA] lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of CTNNB1 mRNA]
|
CTD |
PMID:30731080 PMID:35738543 |
|
NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
|
|
| G
|
Cux2
|
cut-like homeobox 2
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [CUX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 5:121,996,025...122,188,522
Ensembl chr 5:121,994,429...122,188,165
|
|
| G
|
Cxcl13
|
C-X-C motif chemokine ligand 13
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of CXCL13 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 5:96,104,785...96,108,927
Ensembl chr 5:96,104,810...96,108,927
|
|
| G
|
Cxcl15
|
C-X-C motif chemokine ligand 15
|
increases expression multiple interactions
|
ISO
|
lead nitrate results in increased expression of CXCL8 protein [lead nitrate results in increased abundance of Lead] which results in increased secretion of CXCL8 protein
|
CTD |
PMID:34189835 PMID:39579145 |
|
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
|
|
| G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
multiple interactions increases expression
|
ISO
|
lead nitrate inhibits the reaction [1,2,5,6-dibenzanthracene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benz(a)anthracene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(b)fluoranthene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(k)fluoranthene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(k)fluoranthene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; lead nitrate promotes the reaction [benzo(k)fluoranthene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [lead nitrate results in increased expression of CYP1A1 mRNA] lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [lead nitrate results in increased expression of CYP1A1 mRNA] lead nitrate results in increased expression of CYP1A1 mRNA; lead nitrate results in increased expression of CYP1A1 protein
|
CTD |
PMID:8902619 PMID:11162773 PMID:11408366 PMID:17889500 PMID:23391631 PMID:31682781 More...
|
|
NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
|
|
| G
|
Cyp1a2
|
cytochrome P450, family 1, subfamily a, polypeptide 2
|
decreases activity multiple interactions
|
ISO
|
lead nitrate results in decreased activity of CYP1A2 protein lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; lead nitrate results in decreased expression of and results in decreased activity of CYP1A2 protein
|
CTD |
PMID:8902619 PMID:11162773 |
|
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
|
|
| G
|
Cyp2a5
|
cytochrome P450, family 2, subfamily a, polypeptide 5
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in increased expression of CYP2A6 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
|
|
| G
|
Cyp2c52-ps
|
cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene
|
increases expression
|
ISO
|
lead nitrate results in increased expression of CYP2C11 mRNA
|
CTD |
PMID:23391631 |
|
NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733 Ensembl chr19:38,965,091...38,991,733
|
|
| G
|
Cyp4a12b
|
cytochrome P450, family 4, subfamily a, polypeptide 12B
|
increases expression
|
ISO
|
lead nitrate results in increased expression of CYP4A1 mRNA
|
CTD |
PMID:23391631 |
|
NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231
|
|
| G
|
Cyp51
|
cytochrome P450, family 51
|
increases expression multiple interactions
|
EXP ISO
|
lead nitrate results in increased expression of CYP51 mRNA [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]
|
CTD |
PMID:15475176 PMID:22293356 |
|
NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746
|
|
| G
|
Cyp7a1
|
cytochrome P450, family 7, subfamily a, polypeptide 1
|
decreases expression multiple interactions
|
EXP ISO
|
lead nitrate results in decreased expression of CYP7A1 mRNA [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]
|
CTD |
PMID:15475176 PMID:16049268 PMID:22293356 |
|
NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
|
|
| G
|
Ddit3
|
DNA-damage inducible transcript 3
|
increases expression
|
ISO
|
lead nitrate results in increased expression of DDIT3 mRNA
|
CTD |
PMID:14971657 |
|
NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
|
|
| G
|
Dkk1
|
dickkopf WNT signaling pathway inhibitor 1
|
multiple interactions
|
EXP ISO
|
[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 mRNA; [lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 protein] [Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of DKK1 mRNA
|
CTD |
PMID:30731080 PMID:32949613 |
|
NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065
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| G
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Dmp1
|
dentin matrix protein 1
|
multiple interactions
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ISO
|
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of DMP1 mRNA]
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CTD |
PMID:35738543 |
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NCBI chr 5:104,345,441...104,361,968
Ensembl chr 5:104,350,479...104,361,968
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| G
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Dnase1
|
deoxyribonuclease I
|
multiple interactions
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EXP
|
lead nitrate affects the reaction [DNASE1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
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NCBI chr16:3,855,007...3,857,888
Ensembl chr16:3,854,806...3,857,888
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| G
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Dnmt3a
|
DNA methyltransferase 3A
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multiple interactions decreases expression
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ISO
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4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA] lead nitrate results in decreased expression of DNMT3A mRNA; lead nitrate results in decreased expression of DNMT3A protein
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CTD |
PMID:24639330 |
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NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443
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| G
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Dpt
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dermatopontin
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multiple interactions
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ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of DPT mRNA
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CTD |
PMID:32949613 |
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NCBI chr 1:164,624,232...164,651,843
Ensembl chr 1:164,624,213...164,651,835
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| G
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Dspp
|
dentin sialophosphoprotein
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multiple interactions
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ISO
|
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of DSPP mRNA]
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CTD |
PMID:35738543 |
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NCBI chr 5:104,318,569...104,327,993
Ensembl chr 5:104,318,578...104,327,993
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| G
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E2f1
|
E2F transcription factor 1
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multiple interactions
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ISO
|
E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; lead nitrate inhibits the reaction [E2F1 protein results in decreased expression of PTGS2 mRNA]
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CTD |
PMID:24639330 |
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NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812
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| G
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Egfl8
|
EGF-like domain 8
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increases expression
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ISO
|
lead nitrate results in increased expression of EGFL8 protein
|
CTD |
PMID:19332663 |
|
NCBI chr17:34,832,174...34,835,536
Ensembl chr17:34,832,323...34,834,945
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| G
|
Egfr
|
epidermal growth factor receptor
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multiple interactions increases phosphorylation
|
ISO
|
EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; EGFR mutant form affects the reaction [lead nitrate results in increased secretion of Dinoprostone]; EGFR promotes the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of EGFR protein]
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CTD |
PMID:20850495 |
|
NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
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| G
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Eif2ak1
|
eukaryotic translation initiation factor 2 alpha kinase 1
|
increases response to substance multiple interactions
|
EXP
|
EIF2AK1 gene mutant form results in increased susceptibility to lead nitrate [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Bilirubin; [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Malondialdehyde; [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased expression of HAMP mRNA
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CTD |
PMID:25411909 |
|
NCBI chr 5:143,803,586...143,839,535
Ensembl chr 5:143,803,543...143,841,069
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| G
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Eif4ebp1
|
eukaryotic translation initiation factor 4E binding protein 1
|
increases phosphorylation multiple interactions
|
ISO
|
lead nitrate results in increased phosphorylation of EIF4EBP1 protein puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of EIF4EBP1 protein]
|
CTD |
PMID:27762461 |
|
NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702
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| G
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Ercc1
|
excision repair cross-complementing rodent repair deficiency, complementation group 1
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [ERCC1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449
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| G
|
Ercc3
|
excision repair cross-complementing rodent repair deficiency, complementation group 3
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [ERCC3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr18:32,373,357...32,403,206
Ensembl chr18:32,373,353...32,403,204
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| G
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Ezr
|
ezrin
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [EZR affects the expression of MT1 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183
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| G
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Fabp9
|
fatty acid binding protein 9, testis
|
decreases expression
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ISO
|
lead nitrate results in decreased expression of FABP9 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 3:10,258,683...10,262,343
Ensembl chr 3:10,258,681...10,262,343
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| G
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Fdft1
|
farnesyl diphosphate farnesyl transferase 1
|
increases expression
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ISO
|
lead nitrate results in increased expression of FDFT1 mRNA
|
CTD |
PMID:15475176 |
|
NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027
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| G
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Fdps
|
farnesyl diphosphate synthetase
|
increases expression
|
ISO
|
lead nitrate results in increased expression of FDPS mRNA
|
CTD |
PMID:15475176 |
|
NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266
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| G
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Fhl1
|
four and a half LIM domains 1
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of FHL1 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr X:55,776,569...55,838,704
Ensembl chr X:55,777,147...55,838,706
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| G
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Fos
|
FBJ osteosarcoma oncogene
|
increases expression
|
ISO
|
lead nitrate results in increased expression of FOS mRNA
|
CTD |
PMID:14971657 |
|
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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|
| G
|
Foxa2
|
forkhead box A2
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 2:147,884,797...147,888,889
Ensembl chr 2:147,884,797...147,888,889
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| G
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Ftl1
|
ferritin light polypeptide 1
|
increases expression
|
ISO
|
lead nitrate results in increased expression of FTL protein
|
CTD |
PMID:19332663 |
|
NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308
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|
| G
|
G6pdx
|
glucose-6-phosphate dehydrogenase X-linked
|
decreases activity
|
ISO
|
lead nitrate results in decreased activity of G6PD protein
|
CTD |
PMID:28557068 |
|
NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
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|
| G
|
Gadd45a
|
growth arrest and DNA-damage-inducible 45 alpha
|
increases expression
|
ISO
|
lead nitrate results in increased expression of GADD45A mRNA
|
CTD |
PMID:14971657 |
|
NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
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|
| G
|
Garin1b
|
golgi associated RAB2 interactor 1B
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of GARIN1B mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 6:29,313,468...29,336,021
Ensembl chr 6:29,319,139...29,336,018
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|
| G
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Gfap
|
glial fibrillary acidic protein
|
multiple interactions increases expression
|
ISO
|
Ashwagandha inhibits the reaction [lead nitrate results in increased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in increased expression of GFAP protein] lead nitrate results in increased expression of GFAP mRNA; lead nitrate results in increased expression of GFAP protein
|
CTD |
PMID:24987671 |
|
NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
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|
| G
|
Ggnbp1
|
gametogenetin binding protein 1
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of GGNBP1 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr17:27,237,009...27,255,352
Ensembl chr17:27,236,961...27,256,598
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|
| G
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Gh
|
growth hormone
|
multiple interactions decreases secretion
|
ISO
|
lead nitrate inhibits the reaction [GHRH protein results in increased expression of GH1 protein] lead nitrate results in decreased secretion of GH1 protein
|
CTD |
PMID:12022635 |
|
NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691
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|
| G
|
Ghrh
|
growth hormone releasing hormone
|
multiple interactions
|
ISO
|
lead nitrate inhibits the reaction [GHRH protein results in increased expression of GH1 protein]
|
CTD |
PMID:12022635 |
|
NCBI chr 2:157,171,416...157,190,645
Ensembl chr 2:157,171,417...157,189,426
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|
| G
|
Gja5
|
gap junction protein, alpha 5
|
multiple interactions increases expression
|
EXP
|
lead nitrate affects the reaction [GJA5 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT2 mRNA] lead nitrate results in increased expression of GJA5 mRNA
|
CTD |
PMID:11891201 |
|
NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732
|
|
| G
|
Gjb2
|
gap junction protein, beta 2
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [GJB2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159
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|
| G
|
Gm128
|
predicted gene 128
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of C2H1ORF56 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 3:95,144,230...95,148,946
Ensembl chr 3:95,144,231...95,148,909
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|
| G
|
Gm22711
|
predicted gene, 22711
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in increased expression of SNORA50C mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr11:106,392,071...106,392,203
Ensembl chr11:106,392,071...106,392,203 Ensembl chr11:106,392,071...106,392,203
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|
| G
|
Gm24523
|
predicted gene, 24523
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in increased expression of SNORA72 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr15:34,440,937...34,441,068
Ensembl chr15:34,440,937...34,441,068
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|
| G
|
Gm25636
|
predicted gene, 25636
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in increased expression of SNORA13 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 7:109,622,417...109,622,549
Ensembl chr 7:109,622,417...109,622,549
|
|
| G
|
Got1
|
glutamic-oxaloacetic transaminase 1, soluble
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead nitrate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with chromium trioxide co-treated with manganese chloride co-treated with ferric chloride] results in increased expression of GOT1 protein
|
CTD |
PMID:39414706 |
|
NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044
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|
| G
|
Gpt
|
glutamic pyruvic transaminase, soluble
|
multiple interactions
|
EXP
|
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead nitrate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with chromium trioxide co-treated with manganese chloride co-treated with ferric chloride] results in increased expression of GPT protein
|
CTD |
PMID:39414706 |
|
NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
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|
| G
|
Grin2a
|
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [GRIN2A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424
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|
| G
|
Grin2c
|
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
|
increases expression
|
ISO
|
lead nitrate results in increased expression of GRIN2C mRNA
|
CTD |
PMID:23358146 |
|
NCBI chr11:115,139,995...115,158,123
Ensembl chr11:115,139,995...115,158,069
|
|
| G
|
Gsg1
|
germ cell associated 1
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of GSG1 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 6:135,214,327...135,231,334
Ensembl chr 6:135,214,324...135,231,349 Ensembl chr 6:135,214,324...135,231,349
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|
| G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
multiple interactions
|
EXP
|
[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein]
|
CTD |
PMID:30731080 |
|
NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
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|
| G
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Gsr
|
glutathione reductase
|
multiple interactions decreases activity
|
EXP
|
mangiferin inhibits the reaction [lead nitrate results in decreased activity of GSR protein]
|
CTD |
PMID:23451106 |
|
NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
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|
| G
|
Gstt1
|
glutathione S-transferase, theta 1
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418
|
|
| G
|
Hamp
|
hepcidin antimicrobial peptide
|
multiple interactions
|
EXP
|
[lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased expression of HAMP mRNA
|
CTD |
PMID:25411909 |
|
NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
|
|
| G
|
Hmgb4
|
high-mobility group box 4
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of HMGB4 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 4:128,154,005...128,154,688
Ensembl chr 4:128,154,005...128,154,750
|
|
| G
|
Hmgcr
|
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
|
increases expression multiple interactions
|
EXP ISO
|
lead nitrate results in increased expression of HMGCR mRNA [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]
|
CTD |
PMID:15475176 PMID:16705668 PMID:22293356 |
|
NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
|
|
| G
|
Hmox1
|
heme oxygenase 1
|
increases expression
|
ISO
|
lead nitrate results in increased expression of HMOX1 mRNA
|
CTD |
PMID:23391631 PMID:34189835 |
|
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
|
|
| G
|
Hnf4a
|
hepatic nuclear factor 4, alpha
|
decreases expression
|
EXP
|
lead nitrate results in decreased expression of HNF4A mRNA
|
CTD |
PMID:16049268 |
|
NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830
|
|
| G
|
Hsp90ab1
|
heat shock protein 90 alpha (cytosolic), class B member 1
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [HSP90AB1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197
|
|
| G
|
Hspa2
|
heat shock protein 2
|
multiple interactions decreases expression increases expression
|
ISO
|
Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA2 mRNA] lead nitrate results in decreased expression of HSPA2 mRNA
|
CTD |
PMID:21628963 PMID:24987671 |
|
NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712
|
|
| G
|
Hspa5
|
heat shock protein 5
|
increases expression
|
EXP ISO
|
lead nitrate results in increased expression of HSPA5 protein lead nitrate results in increased expression of HSPA5 mRNA
|
CTD |
PMID:14971657 PMID:20435106 |
|
NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
|
|
| G
|
Hspa9
|
heat shock protein 9
|
multiple interactions increases expression
|
ISO
|
Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA9 mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA9 protein] lead nitrate results in increased expression of HSPA9 mRNA; lead nitrate results in increased expression of HSPA9 protein
|
CTD |
PMID:24987671 |
|
NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410
|
|
| G
|
Igf2
|
insulin-like growth factor 2
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [IGF2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553
|
|
| G
|
Igfbp1
|
insulin-like growth factor binding protein 1
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of IGFBP1 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546
|
|
| G
|
Igfbp6
|
insulin-like growth factor binding protein 6
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [IGFBP6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr15:102,052,621...102,057,947
Ensembl chr15:102,052,797...102,057,946
|
|
| G
|
Il1a
|
interleukin 1 alpha
|
multiple interactions increases expression
|
EXP
|
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] results in decreased susceptibility to lead nitrate lead nitrate results in increased expression of IL1A mRNA
|
CTD |
PMID:22293356 |
|
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
|
|
| G
|
Il1b
|
interleukin 1 beta
|
multiple interactions increases expression
|
EXP ISO
|
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] results in decreased susceptibility to lead nitrate lead nitrate results in increased expression of IL1B mRNA lead nitrate results in increased expression of IL1B mRNA; lead nitrate results in increased expression of IL1B protein
|
CTD |
PMID:15475176 PMID:16049268 PMID:22293356 |
|
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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| G
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Il2
|
interleukin 2
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decreases secretion
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ISO
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lead nitrate results in decreased secretion of IL2 protein
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CTD |
PMID:27714827 |
|
NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
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| G
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Il6
|
interleukin 6
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multiple interactions
|
EXP
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[sodium arsenite co-treated with Cadmium Chloride co-treated with lead nitrate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with chromium trioxide co-treated with manganese chloride co-treated with ferric chloride] results in increased expression of IL6 protein
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CTD |
PMID:39414706 |
|
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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| G
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Il6ra
|
interleukin 6 receptor, alpha
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multiple interactions
|
EXP
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lead nitrate affects the reaction [IL6RA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503
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| G
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Ins1
|
insulin I
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multiple interactions
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EXP
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[lead nitrate results in increased abundance of Lead] inhibits the reaction [Glucose results in increased secretion of INS1 protein]
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CTD |
PMID:33038468 |
|
NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
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| G
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Iqcf1
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IQ motif containing F1
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decreases expression
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ISO
|
lead nitrate results in decreased expression of IQCF1 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 9:106,377,166...106,379,449
Ensembl chr 9:106,377,166...106,379,453
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| G
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Iqcf5
|
IQ motif containing F5
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decreases expression
|
ISO
|
lead nitrate results in decreased expression of IQCF5 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 9:106,391,772...106,393,202
Ensembl chr 9:106,391,772...106,393,209
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| G
|
Itga6
|
integrin alpha 6
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multiple interactions
|
EXP
|
lead nitrate affects the reaction [ITGA6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 2:71,617,236...71,688,761
Ensembl chr 2:71,575,960...71,688,760
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| G
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Itgam
|
integrin alpha M
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multiple interactions
|
EXP
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lead nitrate affects the reaction [ITGAM affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
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| G
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Krt14
|
keratin 14
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increases expression
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EXP
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lead nitrate results in increased expression of KRT14 protein
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CTD |
PMID:20435106 |
|
NCBI chr11:100,093,988...100,098,336
Ensembl chr11:100,093,988...100,098,374
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| G
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Lamp1
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lysosomal-associated membrane protein 1
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increases expression
|
EXP
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lead nitrate results in increased expression of LAMP1 protein
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CTD |
PMID:23376802 |
|
NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338
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| G
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Lamp2
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lysosomal-associated membrane protein 2
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increases expression
|
EXP
|
lead nitrate results in increased expression of LAMP2 protein
|
CTD |
PMID:23376802 |
|
NCBI chr X:37,488,524...37,545,337
Ensembl chr X:37,490,234...37,545,331
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| G
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Ldhc
|
lactate dehydrogenase C
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decreases expression
|
ISO
|
lead nitrate results in decreased expression of LDHC mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 7:46,510,687...46,527,571
Ensembl chr 7:46,510,627...46,527,566
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| G
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Lrrc46
|
leucine rich repeat containing 46
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decreases expression
|
ISO
|
lead nitrate results in decreased expression of LRRC46 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr11:96,925,428...96,932,195
Ensembl chr11:96,925,428...96,932,233
|
|
| G
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Lta
|
lymphotoxin A
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [LTA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327
|
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| G
|
Lum
|
lumican
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of LUM mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr10:97,401,363...97,408,565
Ensembl chr10:97,400,990...97,408,565
|
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| G
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Lypd4
|
Ly6/Plaur domain containing 4
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of LYPD4 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 7:24,564,044...24,569,180
Ensembl chr 7:24,564,045...24,569,366
|
|
| G
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Map1lc3b
|
microtubule-associated protein 1 light chain 3 beta
|
multiple interactions
|
ISO
|
[lead nitrate results in increased abundance of Lead] which results in increased expression of MAP1LC3B protein
|
CTD |
PMID:39579145 |
|
NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
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|
| G
|
Mapk1
|
mitogen-activated protein kinase 1
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multiple interactions increases phosphorylation
|
ISO EXP
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2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein] mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]
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CTD |
PMID:20850495 PMID:22502979 PMID:23451106 |
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NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
|
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| G
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Mapk3
|
mitogen-activated protein kinase 3
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multiple interactions increases phosphorylation
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ISO EXP
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2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein] mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]
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CTD |
PMID:20850495 PMID:22502979 PMID:23451106 |
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NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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| G
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Marchf11
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membrane associated ring-CH-type finger 11
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decreases expression
|
ISO
|
lead nitrate results in decreased expression of MARCHF11 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr15:26,309,134...26,409,672
Ensembl chr15:26,309,134...26,409,662
|
|
| G
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Mcl1
|
myeloid cell leukemia sequence 1
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [MCL1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
|
|
| G
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Met
|
met proto-oncogene
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [MET affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 6:17,463,351...17,573,979
Ensembl chr 6:17,463,799...17,573,979
|
|
| G
|
Mgst1
|
microsomal glutathione S-transferase 1
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [MGST1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753
|
|
| G
|
Mir139
|
microRNA 139
|
increases expression
|
ISO
|
lead nitrate results in increased expression of MIR139 mRNA
|
CTD |
PMID:35738543 |
|
NCBI chr 7:101,124,583...101,124,650
Ensembl chr 7:101,124,583...101,124,650
|
|
| G
|
Mir142
|
microRNA 142
|
increases expression
|
ISO
|
lead nitrate results in increased expression of MIR142 mRNA
|
CTD |
PMID:35738543 |
|
NCBI chr11:87,647,690...87,647,753
Ensembl chr11:87,647,690...87,647,753
|
|
| G
|
Mir675
|
microRNA 675
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of MIR675 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 7:142,130,801...142,130,884
Ensembl chr 7:142,130,801...142,130,884
|
|
| G
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Mroh2b
|
maestro heat-like repeat family member 2B
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of MROH2B mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr15:4,927,697...4,991,689
Ensembl chr15:4,928,219...4,991,687
|
|
| G
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mt-Co1
|
cytochrome c oxidase I, mitochondrial
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multiple interactions decreases expression
|
ISO
|
puerarin inhibits the reaction [lead nitrate results in decreased expression of COX1 mRNA]
|
CTD |
PMID:23315276 |
|
NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
|
|
| G
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mt-Co2
|
cytochrome c oxidase II, mitochondrial
|
multiple interactions decreases expression
|
ISO
|
puerarin inhibits the reaction [lead nitrate results in decreased expression of COX2 mRNA]
|
CTD |
PMID:23315276 |
|
NCBI chr MT:7,013...7,696
Ensembl chr MT:7,013...7,696
|
|
| G
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mt-Co3
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cytochrome c oxidase III, mitochondrial
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multiple interactions decreases expression
|
ISO
|
puerarin inhibits the reaction [lead nitrate results in decreased expression of COX3 mRNA]
|
CTD |
PMID:23315276 |
|
NCBI chr MT:8,607...9,390
Ensembl chr MT:8,607...9,390
|
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| G
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Mt1
|
metallothionein 1
|
affects localization decreases response to substance increases expression multiple interactions
|
EXP
|
lead nitrate affects the localization of MT1 protein MT1 results in decreased susceptibility to lead nitrate lead nitrate results in increased expression of MT1 mRNA lead nitrate affects the reaction [CASP7 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT1 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT1 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RAD23 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT1 mRNA]; MT1 protein promotes the reaction [lead nitrate results in increased expression of SNCA mRNA]
|
CTD |
PMID:11891201 PMID:19542206 |
|
NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
|
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| G
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Mt2
|
metallothionein 2
|
multiple interactions decreases response to substance
|
EXP
|
lead nitrate affects the reaction [CASP7 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT2 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT2 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT2 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT2 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT2 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RAD23 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT2 mRNA] MT2 results in decreased susceptibility to lead nitrate
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CTD |
PMID:11891201 |
|
NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
|
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| G
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Mtor
|
mechanistic target of rapamycin kinase
|
multiple interactions increases phosphorylation
|
ISO
|
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein]
|
CTD |
PMID:27762461 |
|
NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
|
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| G
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Myc
|
myelocytomatosis oncogene
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [MYC affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
|
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| G
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Myh6
|
myosin, heavy polypeptide 6, cardiac muscle, alpha
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of MYH6 protein
|
CTD |
PMID:23391631 |
|
NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384
|
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| G
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Myh7
|
myosin, heavy polypeptide 7, cardiac muscle, beta
|
increases expression multiple interactions
|
ISO
|
lead nitrate results in increased expression of MYH7 mRNA; lead nitrate results in increased expression of MYH7 protein resveratrol inhibits the reaction [lead nitrate results in increased expression of MYH7 mRNA]
|
CTD |
PMID:23391631 |
|
NCBI chr14:55,208,141...55,232,083
Ensembl chr14:55,208,141...55,232,083
|
|
| G
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Ncam1
|
neural cell adhesion molecule 1
|
multiple interactions decreases expression
|
ISO
|
Ashwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 protein] lead nitrate results in decreased expression of NCAM1 mRNA; lead nitrate results in decreased expression of NCAM1 protein
|
CTD |
PMID:24987671 |
|
NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225
|
|
| G
|
Neat1
|
nuclear paraspeckle assembly transcript 1 (non-protein coding)
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of NEAT1 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr19:5,874,736...5,895,508
Ensembl chr19:5,874,736...5,897,132
|
|
| G
|
Nfkbia
|
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
|
decreases expression multiple interactions
|
EXP
|
lead nitrate results in decreased expression of NFKBIA protein mangiferin inhibits the reaction [lead nitrate results in decreased expression of NFKBIA protein]
|
CTD |
PMID:23451106 |
|
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
|
|
| G
|
Nfkbib
|
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [NFKBIB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937
|
|
| G
|
Nppb
|
natriuretic peptide type B
|
increases expression
|
ISO
|
lead nitrate results in increased expression of NPPB mRNA
|
CTD |
PMID:23391631 |
|
NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662
|
|
| G
|
Nqo1
|
NAD(P)H dehydrogenase, quinone 1
|
increases expression
|
ISO
|
lead nitrate results in increased expression of NQO1 mRNA
|
CTD |
PMID:23391631 |
|
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
|
|
| G
|
Nr0b2
|
nuclear receptor subfamily 0, group B, member 2
|
decreases expression
|
EXP ISO
|
lead nitrate results in decreased expression of NR0B2 mRNA
|
CTD |
PMID:15475176 PMID:16049268 |
|
NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
|
|
| G
|
Nr1h3
|
nuclear receptor subfamily 1, group H, member 3
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of NR1H3 mRNA
|
CTD |
PMID:15475176 |
|
NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179
|
|
| G
|
Nr5a2
|
nuclear receptor subfamily 5, group A, member 2
|
increases expression
|
EXP
|
lead nitrate results in increased expression of NR5A2 mRNA
|
CTD |
PMID:16049268 |
|
NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186
|
|
| G
|
Numb
|
NUMB endocytic adaptor protein
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [NUMB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr12:83,840,808...83,968,708
Ensembl chr12:83,840,808...83,968,708
|
|
| G
|
Odf1
|
outer dense fiber of sperm tails 1
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of ODF1 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr15:38,219,447...38,226,979
Ensembl chr15:38,219,447...38,226,979
|
|
| G
|
Omd
|
osteomodulin
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of OMD mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr13:49,735,938...49,746,088
Ensembl chr13:49,735,938...49,746,298
|
|
| G
|
Oxct2a
|
3-oxoacid CoA transferase 2A
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of OXCT2A mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 4:123,215,668...123,217,472
Ensembl chr 4:123,215,668...123,217,427
|
|
| G
|
Paqr5
|
progestin and adipoQ receptor family member V
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of PAQR5 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 9:61,861,020...61,934,085
Ensembl chr 9:61,860,763...61,934,138
|
|
| G
|
Pias2
|
protein inhibitor of activated STAT 2
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr18:77,152,883...77,243,406
Ensembl chr18:77,152,904...77,241,496
|
|
| G
|
Pla2g4a
|
phospholipase A2, group IVA (cytosolic, calcium-dependent)
|
multiple interactions increases expression
|
ISO
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; [lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone; EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; EGFR promotes the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]
|
CTD |
PMID:20850495 |
|
NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041
|
|
| G
|
Plac8
|
placenta-specific 8
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of PLAC8 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 5:100,699,455...100,720,119
Ensembl chr 5:100,701,591...100,720,111
|
|
| G
|
Pold1
|
polymerase (DNA directed), delta 1, catalytic subunit
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [POLD1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 7:44,182,168...44,198,239
Ensembl chr 7:44,182,170...44,198,273
|
|
| G
|
Pou3f3
|
POU domain, class 3, transcription factor 3
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [POU3F3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 1:42,734,928...42,739,370
Ensembl chr 1:42,734,085...42,742,336
|
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| G
|
Prm1
|
protamine 1
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of PRM1 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr16:10,614,196...10,614,687
Ensembl chr16:10,614,190...10,623,703
|
|
| G
|
Prm3
|
protamine 3
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of PRM3 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr16:10,608,372...10,608,778
Ensembl chr16:10,608,369...10,608,778
|
|
| G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions increases expression
|
ISO
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein]; [lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone; Decitabine promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; lead nitrate inhibits the reaction [E2F1 protein results in decreased expression of PTGS2 mRNA]; lead nitrate promotes the reaction [RB1 protein results in increased expression of PTGS2 mRNA]; RB1 protein promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein] lead nitrate results in increased expression of PTGS2 mRNA; lead nitrate results in increased expression of PTGS2 protein
|
CTD |
PMID:20850495 PMID:21435385 PMID:24639330 |
|
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
|
|
| G
|
Rb1
|
RB transcriptional corepressor 1
|
multiple interactions increases expression
|
ISO
|
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of RB1 protein]; lead nitrate promotes the reaction [RB1 protein results in increased expression of PTGS2 mRNA]; RB1 protein promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 protein]
|
CTD |
PMID:24639330 |
|
NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262
|
|
| G
|
Rbl2
|
RB transcriptional corepressor like 2
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [RBL2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472
|
|
| G
|
Rela
|
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
|
multiple interactions increases expression
|
EXP ISO
|
mangiferin inhibits the reaction [lead nitrate results in increased expression of RELA protein] lead nitrate results in increased expression of RELA mRNA; lead nitrate results in increased expression of RELA protein RELA promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; RELA promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]
|
CTD |
PMID:23451106 PMID:31682781 |
|
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
|
|
| G
|
Ribc2
|
RIB43A domain with coiled-coils 2
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of RIBC2 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr15:85,016,261...85,028,771
Ensembl chr15:85,016,279...85,028,771
|
|
| G
|
Rps2
|
ribosomal protein S2
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in increased expression of RPS2 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr17:24,939,037...24,940,901
Ensembl chr17:24,937,090...24,940,903
|
|
| G
|
Rps6kb1
|
ribosomal protein S6 kinase, polypeptide 1
|
multiple interactions increases phosphorylation
|
ISO
|
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of RPS6KB1 protein]
|
CTD |
PMID:27762461 |
|
NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631
|
|
| G
|
Runx1
|
runt related transcription factor 1
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [RUNX1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037
|
|
| G
|
Runx2
|
runt related transcription factor 2
|
multiple interactions
|
EXP ISO
|
[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 mRNA; [lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 protein] lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of RUNX2 mRNA]
|
CTD |
PMID:30731080 PMID:35738543 |
|
NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684
|
|
| G
|
Scgn
|
secretagogin, EF-hand calcium binding protein
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in increased expression of SCGN mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr13:24,137,439...24,175,310
Ensembl chr13:24,137,439...24,175,197
|
|
| G
|
Serpina1b
|
serine (or cysteine) preptidase inhibitor, clade A, member 1B
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [SERPINA1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr12:103,694,415...103,704,448
Ensembl chr12:103,694,415...103,796,632
|
|
| G
|
Smcp
|
sperm mitochondria-associated cysteine-rich protein
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of SMCP mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 3:92,491,173...92,496,380
Ensembl chr 3:92,491,174...92,496,304
|
|
| G
|
Snca
|
synuclein, alpha
|
affects localization multiple interactions increases expression
|
EXP
|
lead nitrate affects the localization of SNCA protein MT1 protein promotes the reaction [lead nitrate results in increased expression of SNCA mRNA]
|
CTD |
PMID:19542206 |
|
NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
|
|
| G
|
Snora64
|
small nucleolar RNA, H/ACA box 64
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in increased expression of SNORA64 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr17:24,939,763...24,939,879
Ensembl chr17:24,939,746...24,939,879
|
|
| G
|
Snora65
|
small nucleolar RNA, H/ACA box 65
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in increased expression of SNORA65 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 2:32,853,313...32,853,430
Ensembl chr 2:32,853,303...32,853,432
|
|
| G
|
Socs1
|
suppressor of cytokine signaling 1
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [SOCS1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400
|
|
| G
|
Sod1
|
superoxide dismutase 1, soluble
|
multiple interactions decreases activity
|
ISO
|
Ashwagandha inhibits the reaction [lead nitrate results in decreased activity of SOD1 protein]
|
CTD |
PMID:24987671 |
|
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
|
|
| G
|
Sp3
|
trans-acting transcription factor 3
|
multiple interactions decreases expression
|
EXP
|
lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA] lead nitrate results in decreased expression of SP3 mRNA
|
CTD |
PMID:11891201 |
|
NCBI chr 2:72,766,774...72,810,790
Ensembl chr 2:72,766,771...72,810,790
|
|
| G
|
Spata18
|
spermatogenesis associated 18
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of SPATA18 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 5:73,808,723...73,836,927
Ensembl chr 5:73,808,722...73,836,855
|
|
| G
|
Spata20
|
spermatogenesis associated 20
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of SPATA20 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr11:94,369,730...94,376,136
Ensembl chr11:94,369,730...94,377,005
|
|
| G
|
Spata21
|
spermatogenesis associated 21
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of SPATA21 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 4:140,815,631...140,840,071
Ensembl chr 4:140,815,644...140,840,071
|
|
| G
|
Spata6
|
spermatogenesis associated 6
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of SPATA6 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 4:111,577,151...111,686,339
Ensembl chr 4:111,577,181...111,686,381
|
|
| G
|
Spp2
|
secreted phosphoprotein 2
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of SPP2 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 1:88,334,688...88,356,022
Ensembl chr 1:88,334,683...88,354,160
|
|
| G
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Sqstm1
|
sequestosome 1
|
multiple interactions increases expression
|
EXP ISO
|
lead nitrate affects the reaction [SQSTM1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT2 mRNA] puerarin inhibits the reaction [lead nitrate results in increased expression of SQSTM1 protein]
|
CTD |
PMID:11891201 PMID:27762461 |
|
NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
|
|
| G
|
Srebf2
|
sterol regulatory element binding factor 2
|
increases expression
|
ISO
|
lead nitrate results in increased expression of SREBF2 mRNA
|
CTD |
PMID:15475176 PMID:16705668 |
|
NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580
|
|
| G
|
Sumo1
|
small ubiquitin-like modifier 1
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [SUMO1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 1:59,678,593...59,709,993
Ensembl chr 1:59,625,717...59,709,993
|
|
| G
|
Susd2
|
sushi domain containing 2
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of SUSD2 mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr10:75,472,453...75,479,842
Ensembl chr10:75,472,540...75,479,842
|
|
| G
|
Tbx2
|
T-box 2
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [TBX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr11:85,723,441...85,732,774
Ensembl chr11:85,723,377...85,732,774
|
|
| G
|
Tekt2
|
tektin 2
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of TEKT2 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 4:126,215,914...126,219,481
Ensembl chr 4:126,215,914...126,219,481
|
|
| G
|
Tekt4
|
tektin 4
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of TEKT4 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr17:25,673,511...25,695,576
Ensembl chr17:25,673,515...25,695,576
|
|
| G
|
Tmod1
|
tropomodulin 1
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of TMOD1 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 4:46,038,940...46,116,032
Ensembl chr 4:46,038,935...46,116,032
|
|
| G
|
Tnf
|
tumor necrosis factor
|
multiple interactions increases expression
|
EXP ISO
|
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]; [sodium arsenite co-treated with Cadmium Chloride co-treated with lead nitrate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with chromium trioxide co-treated with manganese chloride co-treated with ferric chloride] results in increased expression of TNF protein [lead nitrate results in increased abundance of Lead] which results in increased secretion of TNF protein Lead nitrate increases expression of Tnf mRNA in liver
|
CTD RGD |
PMID:15475176 PMID:16049268 PMID:22293356 PMID:39414706 PMID:39579145 PMID:9049203 PMID:7943184 More...
|
RGD:14995487, RGD:14995476 |
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
|
|
| G
|
Tnfrsf1a
|
tumor necrosis factor receptor superfamily, member 1a
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [TNFRSF1A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
|
|
| G
|
Tnfrsf1b
|
tumor necrosis factor receptor superfamily, member 1b
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [TNFRSF1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440
|
|
| G
|
Tnp1
|
transition protein 1
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of TNP1 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 1:73,054,233...73,055,058
Ensembl chr 1:73,054,233...73,055,068
|
|
| G
|
Tnp2
|
transition protein 2
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of TNP2 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr16:10,605,799...10,606,519
Ensembl chr16:10,605,800...10,606,524
|
|
| G
|
Tppp2
|
tubulin polymerization-promoting protein family member 2
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of TPPP2 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr14:52,155,887...52,158,161
Ensembl chr14:52,155,882...52,158,157
|
|
| G
|
Trim27
|
tripartite motif-containing 27
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [TRIM27 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr13:21,363,570...21,378,893
Ensembl chr13:21,363,615...21,378,894
|
|
| G
|
Trp53
|
transformation related protein 53
|
increases expression multiple interactions
|
ISO
|
lead nitrate results in increased expression of TP53 mRNA [lead nitrate results in increased abundance of Lead] which results in increased expression of TP53 mRNA; AHR promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]; RELA promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of TP53 mRNA]
|
CTD |
PMID:30738203 PMID:31682781 |
|
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
|
|
| G
|
Trpm2
|
transient receptor potential cation channel, subfamily M, member 2
|
multiple interactions
|
ISO
|
lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]
|
CTD |
PMID:22750002 |
|
NCBI chr10:77,743,556...77,805,746
Ensembl chr10:77,743,556...77,806,397
|
|
| G
|
Tsc22d3
|
TSC22 domain family, member 3
|
multiple interactions
|
EXP
|
[lead nitrate results in increased abundance of Lead] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]
|
CTD |
PMID:29957541 |
|
NCBI chr X:139,440,277...139,501,257
Ensembl chr X:139,440,277...139,501,408
|
|
| G
|
Tsg101
|
tumor susceptibility gene 101
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [TSG101 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 7:46,538,693...46,569,716
Ensembl chr 7:46,538,697...46,569,717
|
|
| G
|
Tssk2
|
testis-specific serine kinase 2
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of TSSK2 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr16:17,716,501...17,717,888
Ensembl chr16:17,716,501...17,717,888
|
|
| G
|
Tssk3
|
testis-specific serine kinase 3
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of TSSK3 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 4:129,382,801...129,385,523
Ensembl chr 4:129,382,807...129,384,815
|
|
| G
|
Ttf1
|
transcription termination factor, RNA polymerase I
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [TTF1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 2:28,950,211...28,977,668
Ensembl chr 2:28,950,274...28,977,668
|
|
| G
|
Tuba8
|
tubulin, alpha 8
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of TUBA8 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 6:121,187,666...121,209,304
Ensembl chr 6:121,187,655...121,203,813
|
|
| G
|
Tulp2
|
TUB like protein 2
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of TULP2 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr 7:45,131,450...45,173,070
Ensembl chr 7:45,131,301...45,173,056
|
|
| G
|
Wnt1
|
wingless-type MMTV integration site family, member 1
|
multiple interactions
|
ISO
|
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA]
|
CTD |
PMID:35738543 |
|
NCBI chr15:98,687,738...98,691,711
Ensembl chr15:98,687,738...98,691,718
|
|
| G
|
Wnt3a
|
wingless-type MMTV integration site family, member 3A
|
multiple interactions
|
EXP
|
[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA; [lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein]
|
CTD |
PMID:30731080 |
|
NCBI chr11:59,138,859...59,181,579
Ensembl chr11:59,138,859...59,181,578
|
|
| G
|
Wnt4
|
wingless-type MMTV integration site family, member 4
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [WNT4 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 4:137,004,946...137,026,812
Ensembl chr 4:137,004,800...137,027,037
|
|
| G
|
Zfhx3
|
zinc finger homeobox 3
|
multiple interactions
|
EXP
|
lead nitrate affects the reaction [ZFHX3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT2 mRNA]
|
CTD |
PMID:11891201 |
|
NCBI chr 8:109,005,975...109,688,272
Ensembl chr 8:108,669,276...109,688,262
|
|
| G
|
Znrf4
|
zinc and ring finger 4
|
decreases expression
|
ISO
|
lead nitrate results in decreased expression of ZNRF4 mRNA
|
CTD |
PMID:21628963 |
|
NCBI chr17:56,818,248...56,819,483
Ensembl chr17:56,818,248...56,819,431
|
|
| G
|
Zp3r
|
zona pellucida 3 receptor
|
multiple interactions
|
ISO
|
[Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate co-treated with lead nitrate co-treated with Mercury] results in decreased expression of C4BPA mRNA
|
CTD |
PMID:32949613 |
|
NCBI chr 1:130,474,847...130,557,371
Ensembl chr 1:130,504,450...130,557,358
|
|
|
|
| G
|
Alb
|
albumin
|
multiple interactions
|
ISO
|
[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in decreased expression of ALB protein
|
CTD |
PMID:28212817 |
|
NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
|
|
| G
|
Ggt1
|
gamma-glutamyltransferase 1
|
multiple interactions increases activity
|
ISO
|
[cupric oxide co-treated with lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein; [cupric oxide co-treated with lead oxide] results in increased activity of GGT1 protein; [lead oxide co-treated with Zinc Oxide] results in increased activity of GGT1 protein lead oxide results in increased activity of GGT1 protein
|
CTD |
PMID:28212817 |
|
NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034
|
|
| G
|
Lhb
|
luteinizing hormone beta
|
decreases expression
|
ISO
|
lead oxide results in decreased expression of LHB protein
|
CTD |
PMID:28212817 |
|
NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
|
|
| G
|
Prl
|
prolactin
|
multiple interactions
|
ISO
|
[cupric oxide co-treated with lead oxide] results in increased expression of PRL protein
|
CTD |
PMID:28212817 |
|
NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
|
|
|
|
| G
|
App
|
amyloid beta precursor protein
|
decreases expression
|
EXP
|
lead tetraacetate results in decreased expression of APP mRNA
|
CTD |
PMID:20865013 |
|
NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
|
|
| G
|
Mapt
|
microtubule-associated protein tau
|
decreases expression
|
EXP
|
lead tetraacetate results in decreased expression of MAPT mRNA
|
CTD |
PMID:20865013 |
|
NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
|
|
| G
|
Nrxn1
|
neurexin I
|
decreases expression
|
EXP
|
lead tetraacetate results in decreased expression of NRXN1 mRNA
|
CTD |
PMID:20865013 |
|
NCBI chr17:90,341,072...91,400,587
Ensembl chr17:90,341,059...91,400,499
|
|
| G
|
Prnp
|
prion protein
|
decreases expression
|
EXP
|
lead tetraacetate results in decreased expression of PRNP mRNA
|
CTD |
PMID:20865013 |
|
NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349
|
|
| G
|
Syp
|
synaptophysin
|
decreases expression
|
EXP
|
lead tetraacetate results in decreased expression of SYP mRNA
|
CTD |
PMID:20865013 |
|
NCBI chr X:7,504,819...7,519,495
Ensembl chr X:7,504,710...7,519,495
|
|
| G
|
Tubb3
|
tubulin, beta 3 class III
|
decreases expression
|
EXP
|
lead tetraacetate results in decreased expression of TUBB3 mRNA
|
CTD |
PMID:20865013 |
|
NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754
|
|
|
|
| G
|
1110004F10Rik
|
RIKEN cDNA 1110004F10 gene
|
affects expression
|
ISO
|
Lead affects the expression of C11ORF58 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 7:115,680,596...115,704,445
Ensembl chr 7:115,638,632...115,704,445
|
|
| G
|
1700123O20Rik
|
RIKEN cDNA 1700123O20 gene
|
affects expression
|
ISO
|
Lead affects the expression of C14ORF119 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr14:54,923,628...54,928,201
Ensembl chr14:54,923,673...54,928,198
|
|
| G
|
1810055G02Rik
|
RIKEN cDNA 1810055G02 gene
|
decreases expression
|
ISO
|
Lead results in decreased expression of C11ORF24 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr19:3,758,343...3,767,882
Ensembl chr19:3,758,293...3,767,881
|
|
| G
|
2010003K11Rik
|
RIKEN cDNA 2010003K11 gene
|
affects methylation
|
ISO
|
Lead affects the methylation of C11ORF86 gene
|
CTD |
PMID:31636367 |
|
NCBI chr19:4,546,816...4,548,611
Ensembl chr19:4,546,816...4,548,611
|
|
| G
|
2210016L21Rik
|
RIKEN cDNA 2210016L21 gene
|
affects splicing
|
ISO
|
Lead affects the splicing of C12ORF43 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 5:115,080,213...115,086,610
Ensembl chr 5:115,080,217...115,087,842
|
|
| G
|
2610524H06Rik
|
RIKEN cDNA 2610524H06 gene
|
increases expression
|
ISO
|
Lead results in increased expression of C12ORF76 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 5:114,959,998...114,961,529
Ensembl chr 5:114,946,257...114,961,529
|
|
| G
|
2700049A03Rik
|
RIKEN cDNA 2700049A03 gene
|
affects expression
|
ISO
|
Lead affects the expression of KIAA0586 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr12:71,183,627...71,356,273
Ensembl chr12:71,183,622...71,290,077
|
|
| G
|
4833439L19Rik
|
RIKEN cDNA 4833439L19 gene
|
affects splicing
|
ISO
|
Lead affects the splicing of KIAA1191 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr13:54,699,031...54,713,195
Ensembl chr13:54,699,031...54,713,248
|
|
| G
|
4930469K13Rik
|
RIKEN cDNA 4930469K13 gene
|
increases expression
|
ISO
|
Lead results in increased expression of C5ORF58 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr11:33,923,961...34,048,554
Ensembl chr11:33,923,961...34,053,738
|
|
| G
|
4930579G24Rik
|
RIKEN cDNA 4930579G24 gene
|
affects expression
|
ISO
|
Lead affects the expression of C4ORF46 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 3:79,536,386...79,540,127
Ensembl chr 3:79,536,386...79,540,127
|
|
| G
|
9930012K11Rik
|
RIKEN cDNA 9930012K11 gene
|
increases expression
|
ISO
|
Lead results in increased expression of C8ORF58 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr14:70,391,854...70,396,951
Ensembl chr14:70,391,854...70,396,951
|
|
| G
|
A130010J15Rik
|
RIKEN cDNA A130010J15 gene
|
affects methylation
|
ISO
|
Lead affects the methylation of C1ORF74 gene
|
CTD |
PMID:31636367 |
|
NCBI chr 1:192,855,777...192,860,145
Ensembl chr 1:192,850,354...192,860,140
|
|
| G
|
A2m
|
alpha-2-macroglobulin
|
affects binding
|
ISO
|
A2M protein binds to Lead
|
CTD |
PMID:23896426 |
|
NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186
|
|
| G
|
A930009A15Rik
|
RIKEN cDNA A930009A15 gene
|
affects binding
|
ISO
|
DCD protein binds to Lead
|
CTD |
PMID:23896426 |
|
NCBI chr10:115,399,555...115,418,359
Ensembl chr10:115,405,891...115,418,353
|
|
| G
|
Aagab
|
alpha- and gamma-adaptin binding protein
|
affects expression
|
ISO
|
Lead affects the expression of AAGAB mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 9:63,509,897...63,551,872
Ensembl chr 9:63,509,942...63,551,870
|
|
| G
|
Abca2
|
ATP-binding cassette, sub-family A member 2
|
affects expression
|
ISO
|
Lead affects the expression of ABCA2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 2:25,318,611...25,338,556
Ensembl chr 2:25,318,715...25,338,552
|
|
| G
|
Abca3
|
ATP-binding cassette, sub-family A member 3
|
affects expression
|
ISO
|
Lead affects the expression of ABCA3 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr17:24,570,997...24,629,178
Ensembl chr17:24,570,924...24,629,175
|
|
| G
|
Abcb1a
|
ATP-binding cassette, sub-family B member 1A
|
affects abundance
|
ISO
|
ABCB1 gene polymorphism affects the abundance of Lead
|
CTD |
PMID:25728017 |
|
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
|
|
| G
|
Abcc3
|
ATP-binding cassette, sub-family C member 3
|
increases expression
|
ISO
|
Lead results in increased expression of ABCC3 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
|
|
| G
|
Abcf1
|
ATP-binding cassette, sub-family F member 1
|
decreases expression
|
ISO
|
Lead results in decreased expression of ABCF1 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr17:36,267,711...36,280,642
Ensembl chr17:36,267,711...36,280,653
|
|
| G
|
Abcg4
|
ATP binding cassette subfamily G member 4
|
affects expression
|
ISO
|
Lead affects the expression of ABCG4 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 9:44,184,485...44,199,953
Ensembl chr 9:44,184,485...44,199,912
|
|
| G
|
Abhd12
|
abhydrolase domain containing 12
|
decreases expression
|
ISO
|
Lead results in decreased expression of ABHD12 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 2:150,674,413...150,746,705
Ensembl chr 2:150,674,413...150,746,661
|
|
| G
|
Abhd2
|
abhydrolase domain containing 2
|
affects expression
|
ISO
|
Lead affects the expression of ABHD2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 7:78,923,002...79,015,257
Ensembl chr 7:78,922,947...79,015,256
|
|
| G
|
Abhd8
|
abhydrolase domain containing 8
|
affects expression
|
ISO
|
Lead affects the expression of ABHD8 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 8:71,909,344...71,917,351
Ensembl chr 8:71,909,349...71,916,299 Ensembl chr 8:71,909,349...71,916,299
|
|
| G
|
Abl2
|
ABL proto-oncogene 2, non-receptor tyrosine kinase
|
decreases expression
|
ISO
|
Lead results in decreased expression of ABL2 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 1:156,386,160...156,477,189
Ensembl chr 1:156,386,356...156,477,138
|
|
| G
|
Ablim1
|
actin-binding LIM protein 1
|
affects splicing affects expression
|
ISO
|
Lead affects the splicing of ABLIM1 mRNA Lead affects the expression of ABLIM1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr19:57,021,165...57,303,776
Ensembl chr19:57,021,165...57,303,351
|
|
| G
|
Ablim2
|
actin-binding LIM protein 2
|
affects expression
|
ISO
|
Lead affects the expression of ABLIM2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 5:35,915,200...36,042,323
Ensembl chr 5:35,915,224...36,042,317
|
|
| G
|
Ablim3
|
actin binding LIM protein family, member 3
|
affects methylation
|
ISO
|
Lead affects the methylation of ABLIM3 gene
|
CTD |
PMID:31636367 |
|
NCBI chr18:61,932,463...62,044,956
Ensembl chr18:61,932,463...62,044,895
|
|
| G
|
Abr
|
active BCR-related gene
|
affects methylation
|
ISO
|
Lead affects the methylation of ABR gene
|
CTD |
PMID:31636367 |
|
NCBI chr11:76,307,560...76,468,515
Ensembl chr11:76,307,560...76,514,384
|
|
| G
|
Abt1
|
activator of basal transcription 1
|
affects expression
|
ISO
|
Lead affects the expression of ABT1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr13:23,602,531...23,608,036
Ensembl chr13:23,602,531...23,608,036
|
|
| G
|
Acaca
|
acetyl-Coenzyme A carboxylase alpha
|
increases expression
|
EXP
|
Lead results in increased expression of ACACA mRNA
|
CTD |
PMID:29529432 |
|
NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
|
|
| G
|
Acacb
|
acetyl-Coenzyme A carboxylase beta
|
decreases expression affects methylation
|
ISO
|
Lead results in decreased expression of ACACB mRNA Lead affects the methylation of ACACB gene
|
CTD |
PMID:19921347 PMID:31636367 |
|
NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822
|
|
| G
|
Acadl
|
acyl-Coenzyme A dehydrogenase, long-chain
|
decreases expression
|
ISO
|
Lead results in decreased expression of ACADL mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 1:66,869,998...66,902,468
Ensembl chr 1:66,869,998...66,902,436
|
|
| G
|
Acadm
|
acyl-Coenzyme A dehydrogenase, medium chain
|
affects expression
|
ISO
|
Lead affects the expression of ACADM mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269
|
|
| G
|
Acbd4
|
acyl-Coenzyme A binding domain containing 4
|
affects expression
|
ISO
|
Lead affects the expression of ACBD4 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr11:102,992,524...103,003,026
Ensembl chr11:102,992,508...103,005,229
|
|
| G
|
Acbd5
|
acyl-Coenzyme A binding domain containing 5
|
affects expression
|
ISO
|
Lead affects the expression of ACBD5 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 2:22,958,189...23,004,525
Ensembl chr 2:22,958,179...23,005,570
|
|
| G
|
Acd
|
adrenocortical dysplasia
|
decreases expression
|
ISO
|
Lead results in decreased expression of ACD mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 8:106,424,789...106,427,748
Ensembl chr 8:106,422,492...106,427,734
|
|
| G
|
Ace
|
angiotensin I converting enzyme
|
increases activity
|
ISO
|
Lead results in increased activity of ACE protein
|
CTD |
PMID:21364929 |
|
NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
|
|
| G
|
Ache
|
acetylcholinesterase
|
decreases activity affects expression multiple interactions
|
ISO
|
Lead results in decreased activity of ACHE protein Lead affects the expression of ACHE mRNA [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased activity of ACHE protein; [lead acetate results in increased abundance of Lead] which results in decreased activity of ACHE protein; [lead acetate results in increased abundance of Lead] which results in increased activity of ACHE protein; Aluminum promotes the reaction [Lead results in decreased activity of ACHE protein]
|
CTD |
PMID:15266904 PMID:15452883 PMID:28903495 PMID:35307918 PMID:35398025 PMID:37415728 More...
|
|
NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
|
|
| G
|
Ackr2
|
atypical chemokine receptor 2
|
increases expression
|
ISO
|
Lead results in increased expression of ACKR2 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 9:121,727,421...121,740,177
Ensembl chr 9:121,727,421...121,740,140
|
|
| G
|
Acox1
|
acyl-Coenzyme A oxidase 1, palmitoyl
|
increases expression
|
EXP
|
Lead results in increased expression of ACOX1 mRNA
|
CTD |
PMID:29529432 |
|
NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
|
|
| G
|
Acp1
|
acid phosphatase 1, soluble
|
affects splicing
|
ISO
|
Lead affects the splicing of ACP1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr12:30,943,325...30,961,616
Ensembl chr12:30,943,325...30,961,588
|
|
| G
|
Acrv1
|
acrosomal vesicle protein 1
|
decreases expression
|
ISO
|
Lead results in decreased expression of ACRV1 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 9:36,604,550...36,610,139
Ensembl chr 9:36,604,516...36,610,139
|
|
| G
|
Acsbg1
|
acyl-CoA synthetase bubblegum family member 1
|
decreases expression
|
ISO
|
Lead results in decreased expression of ACSBG1 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 9:54,512,163...54,569,169
Ensembl chr 9:54,512,161...54,569,154
|
|
| G
|
Acsl4
|
acyl-CoA synthetase long-chain family member 4
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ACSL4 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr X:141,100,989...141,173,792
Ensembl chr X:141,100,989...141,173,531
|
|
| G
|
Acsm1
|
acyl-CoA synthetase medium-chain family member 1
|
decreases expression
|
ISO
|
Lead results in decreased expression of ACSM1 mRNA
|
CTD |
PMID:33194959 |
|
NCBI chr 7:119,217,035...119,261,738
Ensembl chr 7:119,206,249...119,261,738
|
|
| G
|
Acsm3
|
acyl-CoA synthetase medium-chain family member 3
|
increases expression
|
ISO
|
Lead results in increased expression of ACSM3 mRNA
|
CTD |
PMID:37386098 |
|
NCBI chr 7:119,360,106...119,384,119
Ensembl chr 7:119,360,146...119,386,736
|
|
| G
|
Acss1
|
acyl-CoA synthetase short-chain family member 1
|
decreases expression
|
ISO
|
Lead results in decreased expression of ACSS1 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 2:150,460,031...150,510,160
Ensembl chr 2:150,460,025...150,510,420
|
|
| G
|
Acss3
|
acyl-CoA synthetase short-chain family member 3
|
affects expression
|
ISO
|
Lead affects the expression of ACSS3 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr10:106,769,375...106,959,622
Ensembl chr10:106,769,378...106,959,529
|
|
| G
|
Actb
|
actin, beta
|
affects expression
|
ISO
|
Lead affects the expression of ACTB mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509
|
|
| G
|
Actl6a
|
actin-like 6A
|
affects expression
|
ISO
|
Lead affects the expression of ACTL6A mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 3:32,762,695...32,781,122
Ensembl chr 3:32,760,447...32,781,122
|
|
| G
|
Actn1
|
actinin, alpha 1
|
affects methylation
|
ISO EXP
|
Lead affects the methylation of ACTN1 gene
|
CTD |
PMID:31636367 PMID:38833407 |
|
NCBI chr12:80,214,316...80,307,165
Ensembl chr12:80,214,321...80,307,145
|
|
| G
|
Actn2
|
actinin alpha 2
|
affects expression
|
ISO
|
Lead affects the expression of ACTN2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr13:12,284,312...12,355,613
Ensembl chr13:12,284,312...12,355,641
|
|
| G
|
Actn4
|
actinin alpha 4
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of ACTN4 intron
|
CTD |
PMID:33445541 |
|
NCBI chr 7:28,592,673...28,661,799
Ensembl chr 7:28,592,673...28,661,765
|
|
| G
|
Acvr1
|
activin A receptor, type 1
|
affects expression
|
ISO
|
Lead affects the expression of ACVR1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169
|
|
| G
|
Acvr1c
|
activin A receptor, type IC
|
increases expression
|
ISO
|
Lead results in increased expression of ACVR1C mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 2:58,157,465...58,247,909
Ensembl chr 2:58,157,465...58,247,907
|
|
| G
|
Acyp1
|
acylphosphatase 1
|
affects expression
|
ISO
|
Lead affects the expression of ACYP1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr12:85,319,172...85,335,257
Ensembl chr12:85,319,172...85,335,212
|
|
| G
|
Adam23
|
a disintegrin and metallopeptidase domain 23
|
increases methylation
|
EXP
|
Lead results in increased methylation of ADAM23 gene
|
CTD |
PMID:38833407 |
|
NCBI chr 1:63,484,880...63,635,263
Ensembl chr 1:63,485,050...63,635,435
|
|
| G
|
Adam9
|
ADAM metallopeptidase domain 9
|
decreases expression affects expression
|
ISO
|
Lead results in decreased expression of ADAM9 mRNA Lead affects the expression of ADAM9 mRNA
|
CTD |
PMID:22313790 PMID:28903495 |
|
NCBI chr 8:25,439,627...25,507,138
Ensembl chr 8:25,439,627...25,506,943
|
|
| G
|
Adamts1
|
ADAM metallopeptidase with thrombospondin type 1 motif 1
|
affects expression
|
ISO
|
Lead affects the expression of ADAMTS1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001
|
|
| G
|
Adamts12
|
ADAM metallopeptidase with thrombospondin type 1 motif 12
|
affects methylation
|
ISO
|
Lead affects the methylation of ADAMTS12 gene
|
CTD |
PMID:31636367 |
|
NCBI chr15:11,064,781...11,349,321
Ensembl chr15:11,064,876...11,349,317
|
|
| G
|
Adamts2
|
ADAM metallopeptidase with thrombospondin type 1 motif 2
|
affects expression
|
ISO
|
Lead affects the expression of ADAMTS2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr11:50,492,912...50,698,400
Ensembl chr11:50,492,911...50,698,400
|
|
| G
|
Adamts3
|
ADAM metallopeptidase with thrombospondin type 1 motif 3
|
affects expression
|
ISO
|
Lead affects the expression of ADAMTS3 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 5:89,821,700...90,031,521
Ensembl chr 5:89,824,946...90,031,193
|
|
| G
|
Adamts5
|
ADAM metallopeptidase with thrombospondin type 1 motif 5
|
affects expression
|
ISO
|
Lead affects the expression of ADAMTS5 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr16:85,655,045...85,698,013
Ensembl chr16:85,653,061...85,698,716
|
|
| G
|
Adap1
|
ArfGAP with dual PH domains 1
|
affects expression
|
ISO
|
Lead affects the expression of ADAP1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 5:139,257,631...139,311,516
Ensembl chr 5:139,257,631...139,311,377
|
|
| G
|
Adck2
|
aarF domain containing kinase 2
|
affects expression
|
ISO
|
Lead affects the expression of ADCK2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 6:39,550,778...39,565,703
Ensembl chr 6:39,550,807...39,565,703
|
|
| G
|
Adcy2
|
adenylate cyclase 2
|
affects expression
|
ISO
|
Lead affects the expression of ADCY2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr13:68,768,162...69,147,719
Ensembl chr13:68,768,162...69,147,660
|
|
| G
|
Adcy8
|
adenylate cyclase 8
|
affects expression
|
ISO
|
Lead affects the expression of ADCY8 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr15:64,570,884...64,794,145
Ensembl chr15:64,568,933...64,794,145
|
|
| G
|
Adcy9
|
adenylate cyclase 9
|
affects expression
|
ISO
|
Lead affects the expression of ADCY9 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr16:4,102,750...4,255,094
Ensembl chr16:4,105,393...4,238,362
|
|
| G
|
Adcyap1
|
adenylate cyclase activating polypeptide 1
|
affects expression
|
ISO
|
Lead affects the expression of ADCYAP1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr17:93,506,448...93,513,967
Ensembl chr17:93,506,445...93,513,965
|
|
| G
|
Adcyap1r1
|
adenylate cyclase activating polypeptide 1 receptor 1
|
affects splicing
|
ISO
|
Lead affects the splicing of ADCYAP1R1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 6:55,428,486...55,478,440
Ensembl chr 6:55,428,963...55,478,436
|
|
| G
|
Add1
|
adducin 1
|
decreases expression affects splicing
|
ISO
|
Lead results in decreased expression of ADD1 mRNA Lead affects the splicing of ADD1 mRNA
|
CTD |
PMID:19921347 PMID:28903495 |
|
NCBI chr 5:34,731,008...34,789,652
Ensembl chr 5:34,731,008...34,789,652
|
|
| G
|
Adgrb1
|
adhesion G protein-coupled receptor B1
|
affects expression
|
ISO
|
Lead affects the expression of ADGRB1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr15:74,388,045...74,461,314
Ensembl chr15:74,388,044...74,461,314
|
|
| G
|
Adgrb2
|
adhesion G protein-coupled receptor B2
|
affects splicing affects expression
|
ISO
|
Lead affects the splicing of ADGRB2 mRNA Lead affects the expression of ADGRB2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 4:129,878,566...129,916,426
Ensembl chr 4:129,878,663...129,916,426
|
|
| G
|
Adgrl1
|
adhesion G protein-coupled receptor L1
|
affects expression affects splicing
|
ISO
|
Lead affects the expression of ADGRL1 mRNA Lead affects the splicing of ADGRL1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 8:84,626,598...84,668,583
Ensembl chr 8:84,626,734...84,668,583
|
|
| G
|
Adh4
|
alcohol dehydrogenase 4 (class II), pi polypeptide
|
increases expression
|
ISO
|
Lead results in increased expression of ADH4 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653
|
|
| G
|
Adipor1
|
adiponectin receptor 1
|
affects expression
|
ISO
|
Lead affects the expression of ADIPOR1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 1:134,343,116...134,361,089
Ensembl chr 1:134,343,116...134,361,089
|
|
| G
|
Adora1
|
adenosine A1 receptor
|
decreases expression
|
ISO
|
Lead results in decreased expression of ADORA1 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169
|
|
| G
|
Adora2b
|
adenosine A2b receptor
|
affects expression
|
ISO
|
Lead affects the expression of ADORA2B mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr11:62,139,810...62,157,278
Ensembl chr11:62,139,810...62,157,279
|
|
| G
|
Adra2a
|
adrenergic receptor, alpha 2a
|
affects expression
|
ISO
|
Lead affects the expression of ADRA2A mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413
|
|
| G
|
Adsl
|
adenylosuccinate lyase
|
affects expression
|
ISO
|
Lead affects the expression of ADSL mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr15:80,832,691...80,855,148
Ensembl chr15:80,832,691...80,855,147
|
|
| G
|
Aff4
|
AF4/FMR2 family, member 4
|
affects splicing
|
ISO
|
Lead affects the splicing of AFF4 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr11:53,240,807...53,312,657
Ensembl chr11:53,241,660...53,312,657
|
|
| G
|
Aftph
|
aftiphilin
|
decreases expression
|
ISO
|
Lead results in decreased expression of AFTPH mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr11:20,635,084...20,691,599
Ensembl chr11:20,635,084...20,691,589
|
|
| G
|
Agap1
|
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
|
affects expression
|
ISO
|
Lead affects the expression of AGAP1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 1:89,382,533...89,823,004
Ensembl chr 1:89,382,528...89,825,339
|
|
| G
|
Agap2
|
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
|
affects expression
|
ISO
|
Lead affects the expression of AGAP2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr10:126,911,154...126,929,039
Ensembl chr10:126,911,153...126,929,038
|
|
| G
|
Agbl4
|
ATP/GTP binding protein-like 4
|
decreases expression
|
ISO
|
Lead results in decreased expression of AGBL4 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 4:110,254,823...111,521,521
Ensembl chr 4:110,254,858...111,514,707
|
|
| G
|
Ago1
|
argonaute RISC catalytic subunit 1
|
affects expression
|
ISO
|
Lead affects the expression of AGO1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 4:126,328,805...126,362,500
Ensembl chr 4:126,328,805...126,362,376
|
|
| G
|
Agpat5
|
1-acylglycerol-3-phosphate O-acyltransferase 5
|
affects splicing
|
ISO
|
Lead affects the splicing of AGPAT5 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 8:18,896,295...18,934,429
Ensembl chr 8:18,896,293...18,941,377
|
|
| G
|
Agt
|
angiotensinogen
|
decreases activity affects binding
|
ISO
|
Lead results in decreased activity of AGT protein AGT protein binds to Lead
|
CTD |
PMID:11369112 PMID:23896426 |
|
NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
|
|
| G
|
Agtpbp1
|
ATP/GTP binding protein 1
|
affects splicing
|
ISO
|
Lead affects the splicing of AGTPBP1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr13:59,597,348...59,705,184
Ensembl chr13:59,593,556...59,733,041
|
|
| G
|
Ahr
|
aryl-hydrocarbon receptor
|
multiple interactions affects expression
|
EXP ISO
|
AHR protein promotes the reaction [Lead results in increased activity of CRYZ protein]; AHR protein promotes the reaction [Lead results in increased activity of GSTA2 protein]; Lead results in increased activity of [AHR protein binds to ARNT protein] Lead affects the expression of AHR mRNA
|
CTD |
PMID:15297030 PMID:16093525 PMID:23631153 |
|
NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
|
|
| G
|
Ahsg
|
alpha-2-HS-glycoprotein
|
affects methylation
|
ISO
|
Lead affects the methylation of AHSG gene
|
CTD |
PMID:31636367 |
|
NCBI chr16:22,710,793...22,718,193
Ensembl chr16:22,710,027...22,718,199
|
|
| G
|
AI593442
|
expressed sequence AI593442
|
affects expression
|
ISO
|
Lead affects the expression of C11ORF87 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 9:52,584,332...52,593,434
Ensembl chr 9:52,584,342...52,591,080
|
|
| G
|
Aifm1
|
apoptosis-inducing factor, mitochondrion-associated 1
|
multiple interactions decreases expression
|
ISO
|
[amyloid beta-protein (1-40) co-treated with amyloid beta-protein (25-35)] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of AIFM1 protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of AIFM1 protein; amyloid beta-protein (1-40) promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of AIFM1 protein]; amyloid beta-protein (25-35) promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of AIFM1 protein]; PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of AIFM1 protein] Lead results in decreased expression of AIFM1 mRNA
|
CTD |
PMID:19921347 PMID:31874198 PMID:35300571 |
|
NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440
|
|
| G
|
Aifm2
|
apoptosis-inducing factor, mitochondrion-associated 2
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of AIFM2 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr10:61,551,042...61,575,474
Ensembl chr10:61,551,042...61,575,039
|
|
| G
|
Aire
|
autoimmune regulator
|
affects methylation
|
ISO
|
Lead affects the methylation of AIRE gene
|
CTD |
PMID:31636367 |
|
NCBI chr10:77,865,856...77,879,444
Ensembl chr10:77,865,856...77,879,444
|
|
| G
|
Airn
|
antisense Igf2r RNA
|
decreases methylation
|
EXP
|
Lead results in decreased methylation of AIRN gene
|
CTD |
PMID:38833407 |
|
NCBI chr17:12,960,198...13,078,771
Ensembl chr17:12,960,198...13,079,299
|
|
| G
|
Ajuba
|
ajuba LIM protein
|
affects expression
|
ISO
|
Lead affects the expression of AJUBA mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr14:54,804,926...54,815,118
Ensembl chr14:54,804,929...54,815,015
|
|
| G
|
Ak3
|
adenylate kinase 3
|
affects methylation
|
ISO
|
Lead affects the methylation of AK3 gene
|
CTD |
PMID:31636367 |
|
NCBI chr19:28,968,715...29,026,122
Ensembl chr19:28,998,233...29,025,361
|
|
| G
|
Ak5
|
adenylate kinase 5
|
affects expression
|
ISO
|
Lead affects the expression of AK5 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 3:152,168,461...152,373,992
Ensembl chr 3:152,168,452...152,373,997
|
|
| G
|
Akap1
|
A kinase anchor protein 1
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in increased expression of AKAP1 mRNA
|
CTD |
PMID:33445541 |
|
NCBI chr11:88,721,618...88,755,426
Ensembl chr11:88,721,618...88,755,412
|
|
| G
|
Akap10
|
A kinase anchor protein 10
|
affects expression
|
ISO
|
Lead affects the expression of AKAP10 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr11:61,756,029...61,821,134
Ensembl chr11:61,762,133...61,821,078
|
|
| G
|
Akap6
|
A kinase anchor protein 6
|
affects expression
|
ISO
|
Lead affects the expression of AKAP6 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr12:52,745,371...53,202,351
Ensembl chr12:52,746,166...53,202,382
|
|
| G
|
Akr1c20
|
aldo-keto reductase family 1, member C20
|
affects splicing
|
ISO
|
Lead affects the splicing of AKR1C1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344
|
|
| G
|
Akr1c21
|
aldo-keto reductase family 1, member C21
|
affects splicing multiple interactions
|
ISO
|
Lead affects the splicing of AKR1C2 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of AKR1C2 mRNA
|
CTD |
PMID:28903495 PMID:39276841 |
|
NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
|
|
| G
|
Akr1c6
|
aldo-keto reductase family 1, member C6
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of AKR1C1 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr13:4,484,354...4,507,529
Ensembl chr13:4,484,305...4,507,876
|
|
| G
|
Akt1
|
thymoma viral proto-oncogene 1
|
decreases phosphorylation increases phosphorylation multiple interactions
|
ISO
|
Lead results in decreased phosphorylation of AKT1 protein Lead results in increased phosphorylation of AKT1 protein [lead acetate results in increased abundance of Lead] which results in decreased expression of AKT1 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of AKT1 protein; Plant Extracts inhibits the reaction [Lead results in increased phosphorylation of AKT1 protein]
|
CTD |
PMID:22129743 PMID:32976933 PMID:36652739 PMID:37269892 |
|
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
|
|
| G
|
Akt2
|
thymoma viral proto-oncogene 2
|
decreases expression
|
ISO
|
Lead results in decreased expression of AKT2 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
|
|
| G
|
Akt3
|
thymoma viral proto-oncogene 3
|
increases expression
|
ISO
|
Lead results in increased expression of AKT3 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769
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| G
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Aktip
|
AKT interacting protein
|
increases expression
|
ISO
|
Lead results in increased expression of AKTIP mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 8:91,834,267...91,862,122
Ensembl chr 8:91,838,412...91,926,604
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| G
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Alad
|
aminolevulinate, delta-, dehydratase
|
affects abundance decreases activity affects response to substance multiple interactions increases methylation decreases expression increases response to substance
|
ISO
|
ALAD gene SNP affects the abundance of Lead Lead results in decreased activity of ALAD protein ALAD gene polymorphism affects the susceptibility to Lead; ALAD gene SNP affects the susceptibility to Lead; ALAD polymorphism affects the susceptibility to Lead; ALAD protein affects the susceptibility to Lead [Arsenic co-treated with Lead co-treated with Cadmium] results in decreased activity of ALAD protein; [Arsenic co-treated with Lead] results in decreased activity of ALAD protein; [Disulfiram co-treated with Lead] results in decreased activity of ALAD protein; [Lead co-treated with Cadmium] results in decreased activity of ALAD protein; Gallic Acid inhibits the reaction [Lead results in decreased activity of ALAD protein] Lead results in increased methylation of ALAD promoter Lead results in decreased expression of ALAD mRNA; Lead results in decreased expression of ALAD protein [ALAD gene SNP affects the susceptibility to [Opium co-treated with Lead]] which affects the abundance of Lead; [VDR gene polymorphism co-treated with ALAD gene polymorphism] affects the abundance of Lead; [Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; ALAD gene polymorphism affects the abundance of and affects the susceptibility to Lead; ALAD gene polymorphism affects the susceptibility to and affects the abundance of Lead; ALAD gene SNP affects the susceptibility to [Opium co-treated with Lead]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; Uric Acid affects the reaction [ALAD polymorphism affects the susceptibility to Lead] ALAD gene polymorphism results in increased susceptibility to Lead; ALAD gene SNP results in increased susceptibility to Lead; ALAD protein results in increased susceptibility to Lead
|
CTD |
PMID:2748540 PMID:11049814 PMID:15452883 PMID:16140629 PMID:16263504 PMID:16341691 PMID:16487505 PMID:17366816 PMID:17823382 PMID:19515364 PMID:19921347 PMID:19938001 PMID:20123609 PMID:20510440 PMID:21034764 PMID:21241821 PMID:21396434 PMID:21402136 PMID:21439310 PMID:21799727 PMID:21910133 PMID:22101007 PMID:22354675 PMID:23792432 PMID:24500903 PMID:25963508 PMID:30025905 PMID:30081045 More...
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|
NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155
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| G
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Alas1
|
aminolevulinic acid synthase 1
|
increases expression
|
ISO
|
Lead results in increased expression of ALAS1 mRNA
|
CTD |
PMID:37386098 |
|
NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853
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| G
|
Alb
|
albumin
|
affects binding multiple interactions
|
ISO
|
ALB protein binds to Lead [Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]; [Zinc co-treated with Copper co-treated with Manganese co-treated with Potassium Dichromate co-treated with Nickel co-treated with Cadmium co-treated with Lead co-treated with Mercury] affects the expression of ALB protein; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]
|
CTD |
PMID:23896426 PMID:30090589 PMID:37676925 |
|
NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
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|
| G
|
Alcam
|
activated leukocyte cell adhesion molecule
|
affects splicing
|
ISO
|
Lead affects the splicing of ALCAM mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr16:52,069,359...52,273,444
Ensembl chr16:52,069,359...52,274,437
|
|
| G
|
Aldh16a1
|
aldehyde dehydrogenase 16 family, member A1
|
affects expression
|
ISO
|
Lead affects the expression of ALDH16A1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 7:44,791,257...44,804,008
Ensembl chr 7:44,790,108...44,804,008
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|
| G
|
Aldh1b1
|
aldehyde dehydrogenase 1 family, member B1
|
decreases expression
|
ISO
|
Lead results in decreased expression of ALDH1B1 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604
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|
| G
|
Aldh2
|
aldehyde dehydrogenase 2, mitochondrial
|
multiple interactions affects abundance
|
ISO
|
[Ethanol co-treated with Lead] results in decreased expression of and results in decreased activity of ALDH2 protein; Calcium affects the reaction [ALDH2 gene SNP affects the abundance of Lead]; Lead results in decreased expression of and results in decreased activity of ALDH2 protein; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [[Ethanol co-treated with Lead] results in decreased expression of and results in decreased activity of ALDH2 protein]; N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Lead results in decreased expression of and results in decreased activity of ALDH2 protein]; NAD inhibits the reaction [[Ethanol co-treated with Lead] results in decreased expression of and results in decreased activity of ALDH2 protein] [lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of ALDH2 protein]; [lead acetate results in increased abundance of Lead] which affects the expression of ALDH2 protein; Cyanamide affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of ALDH2 protein]]; Cyanamide affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of ALDH2 protein]
|
CTD |
PMID:28212632 PMID:31550440 PMID:37142061 |
|
NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
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|
| G
|
Aldh3a2
|
aldehyde dehydrogenase family 3, subfamily A2
|
decreases expression
|
ISO
|
Lead results in decreased expression of ALDH3A2 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr11:61,114,240...61,158,267
Ensembl chr11:61,114,243...61,158,290
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|
| G
|
Aldh5a1
|
aldhehyde dehydrogenase family 5, subfamily A1
|
affects expression
|
ISO
|
Lead affects the expression of ALDH5A1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr13:25,091,562...25,121,740
Ensembl chr13:25,091,562...25,121,644
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|
| G
|
Aldh9a1
|
aldehyde dehydrogenase 9, subfamily A1
|
decreases expression
|
ISO
|
Lead results in decreased expression of ALDH9A1 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 1:167,177,560...167,196,100
Ensembl chr 1:167,177,560...167,196,101
|
|
| G
|
Aldoc
|
aldolase C, fructose-bisphosphate
|
multiple interactions
|
EXP
|
[[lead acetate results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of ALDOC mRNA; [lead acetate results in increased abundance of Lead] promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ALDOC mRNA]
|
CTD |
PMID:38157908 |
|
NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607
|
|
| G
|
Alg8
|
ALG8 alpha-1,3-glucosyltransferase
|
decreases expression
|
ISO
|
Lead results in decreased expression of ALG8 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 7:97,020,774...97,041,366
Ensembl chr 7:97,020,813...97,041,392
|
|
| G
|
Alkbh7
|
alkB homolog 7
|
increases expression
|
ISO
|
Lead results in increased expression of ALKBH7 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr17:57,304,339...57,306,340
Ensembl chr17:57,304,339...57,306,322
|
|
| G
|
Alox15
|
arachidonate 15-lipoxygenase
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ALOX15 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857
|
|
| G
|
Alox5
|
arachidonate 5-lipoxygenase
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ALOX5 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
|
|
| G
|
Alpi
|
alkaline phosphatase, intestinal
|
multiple interactions
|
ISO
|
[Cadmium co-treated with Lead] results in increased expression of ALPI protein
|
CTD |
PMID:23806787 |
|
NCBI chr 1:87,025,724...87,029,328
Ensembl chr 1:87,025,724...87,029,328
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|
| G
|
Alpl
|
alkaline phosphatase, liver/bone/kidney
|
decreases expression
|
EXP
|
Lead results in decreased expression of ALPL mRNA
|
CTD |
PMID:23086611 |
|
NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
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|
| G
|
Amfr
|
autocrine motility factor receptor
|
affects expression
|
ISO
|
Lead affects the expression of AMFR mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 8:94,698,216...94,739,301
Ensembl chr 8:94,698,216...94,739,470
|
|
| G
|
Amigo2
|
adhesion molecule with Ig like domain 2
|
multiple interactions increases expression
|
EXP
|
Dietary Fats promotes the reaction [Lead results in increased expression of AMIGO2 mRNA]; Lead promotes the reaction [Dietary Fats results in increased expression of AMIGO2 mRNA]
|
CTD |
PMID:34742682 |
|
NCBI chr15:97,141,955...97,145,168
Ensembl chr15:97,142,006...97,145,168
|
|
| G
|
Amn
|
amnionless
|
decreases expression
|
ISO
|
Lead results in decreased expression of AMN mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr12:111,237,530...111,242,860
Ensembl chr12:111,237,529...111,242,860
|
|
| G
|
Amn1
|
antagonist of mitotic exit network 1
|
affects splicing
|
ISO
|
Lead affects the splicing of AMN1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 6:149,059,075...149,090,210
Ensembl chr 6:149,058,645...149,090,210
|
|
| G
|
Ampd3
|
adenosine monophosphate deaminase 3
|
increases methylation
|
EXP
|
Lead results in increased methylation of AMPD3 gene
|
CTD |
PMID:38833407 |
|
NCBI chr 7:110,367,291...110,411,612
Ensembl chr 7:110,367,413...110,411,612
|
|
| G
|
Anapc2
|
anaphase promoting complex subunit 2
|
decreases expression
|
ISO
|
Lead results in decreased expression of ANAPC2 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 2:25,162,469...25,175,928
Ensembl chr 2:25,162,490...25,175,927
|
|
| G
|
Anapc5
|
anaphase-promoting complex subunit 5
|
decreases expression
|
ISO
|
Lead results in decreased expression of ANAPC5 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 5:122,925,522...122,960,402
Ensembl chr 5:122,925,522...122,959,402
|
|
| G
|
Ank1
|
ankyrin 1, erythroid
|
affects expression affects methylation
|
ISO
|
Lead affects the expression of ANK1 mRNA Lead affects the methylation of ANK1 gene
|
CTD |
PMID:28903495 PMID:31636367 |
|
NCBI chr 8:23,464,852...23,640,517
Ensembl chr 8:23,464,860...23,640,513
|
|
| G
|
Ank2
|
ankyrin 2, brain
|
affects splicing multiple interactions
|
ISO EXP
|
Lead affects the splicing of ANK2 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of ANK2 mRNA
|
CTD |
PMID:28903495 PMID:33445541 |
|
NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999
|
|
| G
|
Ank3
|
ankyrin 3, epithelial
|
affects splicing
|
ISO
|
Lead affects the splicing of ANK3 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr10:69,234,608...69,863,266
Ensembl chr10:69,234,603...69,863,268
|
|
| G
|
Ankdd1a
|
ankyrin repeat and death domain containing 1A
|
affects expression
|
ISO
|
Lead affects the expression of ANKDD1A mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 9:65,395,746...65,427,691
Ensembl chr 9:65,395,752...65,427,475
|
|
| G
|
Ankfn1
|
ankyrin-repeat and fibronectin type III domain containing 1
|
affects expression
|
ISO
|
Lead affects the expression of ANKFN1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr11:89,280,918...89,668,727
Ensembl chr11:89,281,049...89,732,092
|
|
| G
|
Ankhd1
|
ankyrin repeat and KH domain containing 1
|
decreases expression
|
ISO
|
Lead results in decreased expression of ANKHD1 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr18:36,693,656...36,791,961
Ensembl chr18:36,693,040...36,791,966
|
|
| G
|
Ankra2
|
ankyrin repeat family A member 2
|
affects expression
|
ISO
|
Lead affects the expression of ANKRA2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr13:98,399,584...98,411,262
Ensembl chr13:98,399,582...98,411,262
|
|
| G
|
Ankrd12
|
ankyrin repeat domain 12
|
affects expression affects splicing
|
ISO
|
Lead affects the expression of ANKRD12 mRNA Lead affects the splicing of ANKRD12 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr17:66,272,698...66,386,242
Ensembl chr17:66,272,693...66,384,084
|
|
| G
|
Ankrd13a
|
ankyrin repeat domain 13a
|
affects expression
|
ISO
|
Lead affects the expression of ANKRD13A mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 5:114,913,009...114,943,882
Ensembl chr 5:114,912,738...114,944,261
|
|
| G
|
Ankrd13c
|
ankyrin repeat domain 13c
|
affects expression
|
ISO
|
Lead affects the expression of ANKRD13C mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 3:157,650,886...157,713,671
Ensembl chr 3:157,652,876...157,713,671
|
|
| G
|
Ankrd16
|
ankyrin repeat domain 16
|
decreases expression
|
ISO
|
Lead results in decreased expression of ANKRD16 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 2:11,781,902...11,795,138
Ensembl chr 2:11,782,687...11,795,140
|
|
| G
|
Ankrd46
|
ankyrin repeat domain 46
|
affects expression
|
ISO
|
Lead affects the expression of ANKRD46 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr15:36,477,814...36,496,937
Ensembl chr15:36,477,814...36,496,966
|
|
| G
|
Ankrd6
|
ankyrin repeat domain 6
|
decreases expression
|
ISO
|
Lead results in decreased expression of ANKRD6 mRNA
|
CTD |
PMID:37386098 |
|
NCBI chr 4:32,804,027...32,950,884
Ensembl chr 4:32,804,035...32,950,841
|
|
| G
|
Ano1
|
anoctamin 1, calcium activated chloride channel
|
affects methylation
|
ISO
|
Lead affects the methylation of ANO1 gene
|
CTD |
PMID:31636367 |
|
NCBI chr 7:144,142,286...144,305,762
Ensembl chr 7:144,142,286...144,305,711
|
|
| G
|
Ano2
|
anoctamin 2
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of ANO2 exon; [lead acetate results in increased abundance of Lead] which results in decreased methylation of ANO2 intron; [lead acetate results in increased abundance of Lead] which results in decreased methylation of ANO2 promoter
|
CTD |
PMID:33445541 |
|
NCBI chr 6:125,667,382...126,017,115
Ensembl chr 6:125,667,382...126,017,089
|
|
| G
|
Anp32a
|
acidic nuclear phosphoprotein 32 family member A
|
multiple interactions
|
EXP
|
[lead acetate results in increased abundance of Lead] which results in decreased methylation of ANP32A exon; [lead acetate results in increased abundance of Lead] which results in decreased methylation of ANP32A intron
|
CTD |
PMID:33445541 |
|
NCBI chr 9:62,248,637...62,286,084
Ensembl chr 9:62,248,575...62,286,094
|
|
| G
|
Anxa1
|
annexin A1
|
affects activity multiple interactions
|
ISO
|
Lead affects the activity of ANXA1 protein Lead affects the reaction [[Magnesium co-treated with Adenosine Triphosphate] affects the activity of ANXA1 protein]
|
CTD |
PMID:20655937 |
|
NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
|
|
| G
|
Anxa2
|
annexin A2
|
decreases expression affects binding
|
ISO
|
Lead results in decreased expression of ANXA2 mRNA ANXA2 protein binds to Lead
|
CTD |
PMID:19921347 PMID:23896426 |
|
NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077
|
|
| G
|
Anxa4
|
annexin A4
|
decreases expression
|
ISO
|
Lead results in decreased expression of ANXA4 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 6:86,713,822...86,770,616
Ensembl chr 6:86,713,822...86,770,566
|
|
| G
|
Anxa5
|
annexin A5
|
affects expression
|
ISO
|
Lead affects the expression of ANXA5 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043
|
|
| G
|
Ap2a1
|
adaptor-related protein complex 2, alpha 1 subunit
|
affects splicing
|
ISO
|
Lead affects the splicing of AP2A1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 7:44,549,797...44,578,914
Ensembl chr 7:44,549,797...44,578,920
|
|
| G
|
Ap2b1
|
adaptor-related protein complex 2, beta 1 subunit
|
affects expression affects splicing
|
ISO
|
Lead affects the expression of AP2B1 mRNA Lead affects the splicing of AP2B1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr11:83,189,545...83,295,861
Ensembl chr11:83,189,850...83,295,861
|
|
| G
|
Ap2m1
|
adaptor-related protein complex 2, mu 1 subunit
|
decreases expression
|
ISO
|
Lead results in decreased expression of AP2M1 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr16:20,354,230...20,363,659
Ensembl chr16:20,354,228...20,363,659
|
|
| G
|
Ap3m1
|
adaptor-related protein complex 3, mu 1 subunit
|
affects expression
|
ISO
|
Lead affects the expression of AP3M1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr14:21,083,810...21,102,603
Ensembl chr14:21,081,510...21,102,576
|
|
| G
|
Ap4e1
|
adaptor-related protein complex AP-4, epsilon 1
|
affects expression
|
ISO
|
Lead affects the expression of AP4E1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 2:126,850,600...126,911,734
Ensembl chr 2:126,850,637...126,909,829
|
|
| G
|
Apba1
|
amyloid beta precursor protein binding family A member 1
|
affects expression
|
ISO
|
Lead affects the expression of APBA1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr19:23,736,170...23,926,961
Ensembl chr19:23,736,251...23,926,960
|
|
| G
|
Apba2
|
amyloid beta precursor protein binding family A member 2
|
affects splicing
|
ISO
|
Lead affects the splicing of APBA2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 7:64,151,444...64,403,620
Ensembl chr 7:64,151,454...64,403,626
|
|
| G
|
Apcs
|
amyloid P component, serum
|
affects binding
|
ISO
|
APCS protein binds to Lead
|
CTD |
PMID:23896426 |
|
NCBI chr 1:172,721,528...172,722,516
Ensembl chr 1:172,721,528...172,722,608
|
|
| G
|
Apex1
|
apurinic/apyrimidinic endonuclease 1
|
multiple interactions affects expression affects response to substance
|
ISO
|
APEX1 protein inhibits the reaction [Lead results in decreased activity of APEX1 protein] Lead affects the expression of APEX1 mRNA APEX1 gene polymorphism affects the susceptibility to Lead
|
CTD |
PMID:17013835 PMID:22466227 PMID:28903495 |
|
NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596
|
|
| G
|
Aph1a
|
aph1 homolog A, gamma secretase subunit
|
increases expression
|
ISO
|
Lead results in increased expression of APH1A mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 3:95,801,233...95,805,904
Ensembl chr 3:95,801,281...95,805,600
|
|
| G
|
Aplp2
|
amyloid beta precursor-like protein 2
|
decreases expression affects expression affects splicing
|
ISO
|
Lead results in decreased expression of APLP2 mRNA Lead affects the expression of APLP2 mRNA Lead affects the splicing of APLP2 mRNA
|
CTD |
PMID:19921347 PMID:28903495 |
|
NCBI chr 9:31,060,853...31,123,144
Ensembl chr 9:31,060,853...31,123,111
|
|
| G
|
Apoa1
|
apolipoprotein A-I
|
affects binding
|
ISO
|
APOA1 protein binds to Lead
|
CTD |
PMID:23896426 |
|
NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
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| G
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Apoa2
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apolipoprotein A-II
|
affects binding
|
ISO
|
APOA2 protein binds to Lead
|
CTD |
PMID:23896426 |
|
NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948
|
|
| G
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Apoe
|
apolipoprotein E
|
affects expression
|
ISO
|
Lead affects the expression of APOE protein
|
CTD |
PMID:20681587 |
|
NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
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|
| G
|
Apol9a
|
apolipoprotein L 9a
|
decreases expression affects expression
|
ISO
|
Lead results in decreased expression of APOL4 mRNA Lead affects the expression of APOL4 mRNA
|
CTD |
PMID:19921347 PMID:28903495 |
|
NCBI chr15:77,287,989...77,295,280
Ensembl chr15:77,287,989...77,295,335
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|
| G
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App
|
amyloid beta precursor protein
|
decreases expression increases expression multiple interactions affects expression affects splicing increases secretion increases localization affects abundance
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ISO EXP
|
Lead results in decreased expression of APP protein modified form Lead results in increased expression of APP protein [lead acetate results in increased abundance of Lead] which results in increased expression of APP mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of APP protein; fisetin inhibits the reaction [Lead results in increased expression of APP protein] Lead affects the expression of APP mRNA Lead affects the splicing of APP mRNA Lead results in increased expression of APP mRNA; Lead results in increased expression of APP protein [[lead acetate results in increased abundance of Lead] which co-treated with APP protein modified form] results in decreased expression of SYP protein; [lead acetate results in increased abundance of Lead] promotes the reaction [[APP protein co-treated with APP protein modified form] results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [[APP protein co-treated with APP protein modified form] results in decreased expression of SYP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein binds to APP protein modified form]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein binds to APP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form binds to APP protein modified form]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein modified form results in increased expression of BACE1 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in decreased expression of GAP43 protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in decreased expression of SYP protein]; [lead acetate results in increased abundance of Lead] promotes the reaction [APP protein results in increased expression of BACE1 protein]; [Lead co-treated with APP protein co-treated with APP protein modified form] results in increased expression of BACE1 protein; [Lead co-treated with APP protein modified form] results in increased abundance of 8-epi-prostaglandin F2alpha; [Lead co-treated with APP protein modified form] results in increased expression of PTGS2 protein; [Lead co-treated with APP protein modified form] results in increased expression of TP53 protein Lead results in increased secretion of APP protein alternative form Lead results in increased expression of APP protein alternative form Lead results in increased localization of APP protein Lead affects the abundance of APP mRNA; Lead affects the abundance of APP protein [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased metabolism of APP protein]; [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [PSEN1 protein results in increased metabolism of APP protein]; [Arsenic co-treated with Cadmium co-treated with Lead] results in increased expression of APP protein alternative form; Arsenic promotes the reaction [Lead results in increased expression of APP protein alternative form]; Lead affects the reaction [APP protein binds to APP protein]; PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]]
|
CTD |
PMID:16230335 PMID:19921347 PMID:20488202 PMID:21315759 PMID:22272629 PMID:22313790 PMID:22610977 PMID:25288670 PMID:25673500 PMID:28903495 PMID:31539617 PMID:31730887 PMID:31843630 PMID:32058320 More...
|
|
NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
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|
| G
|
Aqp1
|
aquaporin 1
|
affects expression
|
ISO
|
Lead affects the expression of AQP1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540
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|
| G
|
Aqp4
|
aquaporin 4
|
affects expression
|
ISO
|
Lead affects the expression of AQP4 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039
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|
| G
|
Aqr
|
aquarius
|
affects expression
|
ISO
|
Lead affects the expression of AQR mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 2:113,931,642...114,005,788
Ensembl chr 2:113,931,651...114,017,505
|
|
| G
|
Araf
|
Araf proto-oncogene, serine/threonine kinase
|
decreases expression
|
ISO
|
Lead results in decreased expression of ARAF mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr X:20,663,946...20,726,760
Ensembl chr X:20,664,053...20,726,758
|
|
| G
|
Arc
|
activity regulated cytoskeletal-associated protein
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in decreased expression of ARC mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of ARC protein; asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of ARC mRNA]; asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of ARC protein]
|
CTD |
PMID:27936013 PMID:39947421 |
|
NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419
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|
| G
|
Arf3
|
ARF GTPase 3
|
decreases expression
|
ISO
|
Lead results in decreased expression of ARF3 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr15:98,635,505...98,660,999
Ensembl chr15:98,634,515...98,661,095
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|
| G
|
Arg1
|
arginase, liver
|
decreases expression multiple interactions
|
ISO
|
Lead results in decreased expression of ARG1 mRNA [Lead co-treated with amyloid beta-protein (1-40) co-treated with amyloid beta-protein (25-35)] results in decreased expression of ARG1 mRNA; [Lead co-treated with amyloid beta-protein (1-40)] results in decreased expression of ARG1 mRNA; [Lead co-treated with amyloid beta-protein (1-40)] results in decreased expression of ARG1 protein; [Lead co-treated with amyloid beta-protein (25-35)] results in decreased expression of ARG1 mRNA
|
CTD |
PMID:38700421 |
|
NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
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|
| G
|
Arhgap1
|
Rho GTPase activating protein 1
|
affects splicing
|
ISO
|
Lead affects the splicing of ARHGAP1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 2:91,480,463...91,502,670
Ensembl chr 2:91,480,205...91,502,671
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|
| G
|
Arhgap20
|
Rho GTPase activating protein 20
|
affects expression
|
ISO
|
Lead affects the expression of ARHGAP20 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 9:51,676,651...51,765,158
Ensembl chr 9:51,676,637...51,765,156
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|
| G
|
Arhgap22
|
Rho GTPase activating protein 22
|
increases expression
|
ISO
|
Lead results in increased expression of ARHGAP22 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr14:32,935,952...33,091,893
Ensembl chr14:32,935,983...33,091,891
|
|
| G
|
Arhgap29
|
Rho GTPase activating protein 29
|
affects expression
|
ISO
|
Lead affects the expression of ARHGAP29 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 3:121,746,752...121,810,326
Ensembl chr 3:121,746,190...121,810,402
|
|
| G
|
Arhgap30
|
Rho GTPase activating protein 30
|
decreases expression
|
ISO
|
Lead results in decreased expression of ARHGAP30 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 1:171,216,528...171,237,808
Ensembl chr 1:171,216,522...171,237,866
|
|
| G
|
Arhgap31
|
Rho GTPase activating protein 31
|
increases expression
|
ISO
|
Lead results in increased expression of ARHGAP31 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr16:38,418,705...38,533,397
Ensembl chr16:38,418,702...38,533,636
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|
| G
|
Arhgap42
|
Rho GTPase activating protein 42
|
affects expression
|
ISO
|
Lead affects the expression of ARHGAP42 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 9:8,992,508...9,239,032
Ensembl chr 9:8,994,330...9,239,106
|
|
| G
|
Arhgdia
|
Rho GDP dissociation inhibitor alpha
|
decreases expression
|
ISO
|
Lead results in decreased expression of ARHGDIA mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr11:120,468,925...120,472,450
Ensembl chr11:120,468,930...120,472,450
|
|
| G
|
Arhgdig
|
Rho GDP dissociation inhibitor gamma
|
affects expression
|
ISO
|
Lead affects the expression of ARHGDIG mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr17:26,418,157...26,420,324
Ensembl chr17:26,418,157...26,426,760
|
|
| G
|
Arhgef12
|
Rho guanine nucleotide exchange factor 12
|
affects splicing
|
ISO
|
Lead affects the splicing of ARHGEF12 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 9:42,875,138...43,017,069
Ensembl chr 9:42,875,138...43,018,534
|
|
| G
|
Arhgef2
|
Rho/Rac guanine nucleotide exchange factor 2
|
affects methylation
|
ISO
|
Lead affects the methylation of ARHGEF2 gene
|
CTD |
PMID:31636367 |
|
NCBI chr 3:88,500,427...88,556,839
Ensembl chr 3:88,513,273...88,555,359
|
|
| G
|
Arhgef3
|
Rho guanine nucleotide exchange factor 3
|
affects expression
|
ISO
|
Lead affects the expression of ARHGEF3 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr14:26,836,418...27,125,873
Ensembl chr14:26,836,856...27,125,868
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|
| G
|
Arhgef4
|
Rho guanine nucleotide exchange factor 4
|
affects expression affects methylation
|
ISO
|
Lead affects the expression of ARHGEF4 mRNA Lead affects the methylation of ARHGEF4 gene
|
CTD |
PMID:28903495 PMID:31636367 |
|
NCBI chr 1:34,717,263...34,851,819
Ensembl chr 1:34,717,269...34,852,390
|
|
| G
|
Ark2n
|
arkadia (RNF111) N-terminal like PKA signaling regulator 2N
|
decreases expression
|
ISO
|
Lead results in decreased expression of ARK2N mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr18:77,719,184...77,802,190
Ensembl chr18:77,719,193...77,802,186
|
|
| G
|
Arl1
|
ADP-ribosylation factor-like 1
|
affects splicing
|
ISO
|
Lead affects the splicing of ARL1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr10:88,566,720...88,579,956
Ensembl chr10:88,566,720...88,579,956
|
|
| G
|
Arl5a
|
ADP-ribosylation factor-like 5A
|
affects splicing
|
ISO
|
Lead affects the splicing of ARL5A mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 2:52,287,961...52,314,886
Ensembl chr 2:52,287,963...52,314,913
|
|
| G
|
Arl8a
|
ADP-ribosylation factor-like 8A
|
affects expression
|
ISO
|
Lead affects the expression of ARL8A mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 1:135,074,572...135,084,007
Ensembl chr 1:135,074,562...135,084,007
|
|
| G
|
Arln
|
allregulin
|
increases expression
|
ISO
|
Lead results in increased expression of ARLN mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 3:122,718,046...122,719,843
Ensembl chr 3:122,717,852...122,719,833
|
|
| G
|
Armc8
|
armadillo repeat containing 8
|
affects splicing
|
ISO
|
Lead affects the splicing of ARMC8 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 9:99,360,438...99,451,471
Ensembl chr 9:99,360,425...99,450,952
|
|
| G
|
Arnt
|
aryl hydrocarbon receptor nuclear translocator
|
multiple interactions increases expression
|
EXP ISO
|
Lead results in increased activity of [AHR protein binds to ARNT protein] Lead results in increased expression of ARNT mRNA
|
CTD |
PMID:16093525 PMID:19921347 |
|
NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551
|
|
| G
|
Arpc1a
|
actin related protein 2/3 complex, subunit 1A
|
affects expression
|
ISO
|
Lead affects the expression of ARPC1A mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 5:145,020,679...145,045,566
Ensembl chr 5:145,020,640...145,045,571
|
|
| G
|
Arpc2
|
actin related protein 2/3 complex, subunit 2
|
increases expression
|
ISO
|
Lead results in increased expression of ARPC2 mRNA
|
CTD |
PMID:37386098 |
|
NCBI chr 1:74,275,656...74,307,368
Ensembl chr 1:74,275,243...74,307,368
|
|
| G
|
Arrdc1
|
arrestin domain containing 1
|
decreases expression
|
ISO
|
Lead results in decreased expression of ARRDC1 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 2:24,815,364...24,825,347
Ensembl chr 2:24,815,364...24,825,264
|
|
| G
|
Arrdc2
|
arrestin domain containing 2
|
affects expression
|
ISO
|
Lead affects the expression of ARRDC2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 8:71,287,773...71,293,173
Ensembl chr 8:71,287,773...71,292,364
|
|
| G
|
Artn
|
artemin
|
decreases expression
|
ISO
|
Lead results in decreased expression of ARTN mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr 4:117,783,105...117,787,993
Ensembl chr 4:117,783,359...117,786,960
|
|
| G
|
Asah1
|
N-acylsphingosine amidohydrolase 1
|
affects expression
|
ISO
|
Lead affects the expression of ASAH1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810
|
|
| G
|
Asb2
|
ankyrin repeat and SOCS box-containing 2
|
decreases expression
|
ISO
|
Lead results in decreased expression of ASB2 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr12:103,287,401...103,322,260
Ensembl chr12:103,287,401...103,322,260
|
|
| G
|
Ascc2
|
activating signal cointegrator 1 complex subunit 2
|
affects expression
|
ISO
|
Lead affects the expression of ASCC2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr11:4,587,698...4,635,699
Ensembl chr11:4,587,747...4,635,699
|
|
| G
|
Asns
|
asparagine synthetase
|
increases expression
|
ISO
|
Lead results in increased expression of ASNS mRNA
|
CTD |
PMID:37386098 |
|
NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254
|
|
| G
|
Asph
|
aspartate-beta-hydroxylase
|
affects expression
|
ISO
|
Lead affects the expression of ASPH mRNA
|
CTD |
PMID:22313790 |
|
NCBI chr 4:9,449,085...9,669,344
Ensembl chr 4:9,448,069...9,669,344
|
|
| G
|
Asphd1
|
aspartate beta-hydroxylase domain containing 1
|
affects expression
|
ISO
|
Lead affects the expression of ASPHD1 mRNA
|
CTD |
PMID:22313790 |
|
NCBI chr 7:126,545,159...126,548,754
Ensembl chr 7:126,544,739...126,548,754
|
|
| G
|
Asphd2
|
aspartate beta-hydroxylase domain containing 2
|
affects expression
|
ISO
|
Lead affects the expression of ASPHD2 mRNA
|
CTD |
PMID:22313790 |
|
NCBI chr 5:112,532,220...112,543,236
Ensembl chr 5:112,532,220...112,542,732
|
|
| G
|
Aspscr1
|
ASPSCR1 tether for SLC2A4, UBX domain containing
|
decreases expression
|
ISO
|
Lead results in decreased expression of ASPSCR1 mRNA
|
CTD |
PMID:19921347 |
|
NCBI chr11:120,563,878...120,600,273
Ensembl chr11:120,563,799...120,600,273
|
|
| G
|
Atad2b
|
ATPase family, AAA domain containing 2B
|
affects expression
|
ISO
|
Lead affects the expression of ATAD2B mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr12:4,964,404...5,097,396
Ensembl chr12:4,967,353...5,097,394
|
|
| G
|
Atad5
|
ATPase family, AAA domain containing 5
|
increases expression affects expression
|
ISO
|
Lead results in increased expression of ATAD5 mRNA Lead affects the expression of ATAD5 mRNA
|
CTD |
PMID:19921347 PMID:28903495 |
|
NCBI chr11:79,980,205...80,026,623
Ensembl chr11:79,980,226...80,026,620
|
|
| G
|
Atf2
|
activating transcription factor 2
|
affects splicing
|
ISO
|
Lead affects the splicing of ATF2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983
|
|
| G
|
Atf4
|
activating transcription factor 4
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ATF4 mRNA
|
CTD |
PMID:39547369 |
|
NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742
|
|
| G
|
Atf5
|
activating transcription factor 5
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ATF5 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of ATF5 protein; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of CLPP mRNA]; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HSPD1 mRNA]; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of LONP1 mRNA]; ATF5 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of LONP1 protein]; ATF5 protein affects the susceptibility to [lead acetate results in increased abundance of Lead]; ATF5 protein results in decreased susceptibility to [lead acetate results in increased abundance of Lead]
|
CTD |
PMID:39547369 |
|
NCBI chr 7:44,461,680...44,466,082
Ensembl chr 7:44,461,680...44,466,082
|
|
| G
|
Atg5
|
autophagy related 5
|
multiple interactions
|
EXP ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ATG5 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of ATG5 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of ATG5 protein
|
CTD |
PMID:33445541 PMID:36652739 |
|
NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287
|
|
| G
|
Atg7
|
autophagy related 7
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ATG7 mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575
|
|
| G
|
Atl1
|
atlastin GTPase 1
|
affects expression
|
ISO
|
Lead affects the expression of ATL1 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr12:69,939,879...70,010,859
Ensembl chr12:69,939,388...70,013,191
|
|
| G
|
Atm
|
ataxia telangiectasia mutated
|
multiple interactions
|
ISO
|
[lead acetate results in increased abundance of Lead] which results in increased expression of ATM mRNA
|
CTD |
PMID:39276841 |
|
NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
|
|
| G
|
Atp10b
|
ATPase, class V, type 10B
|
affects expression
|
ISO
|
Lead affects the expression of ATP10B mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr11:42,902,991...43,153,112
Ensembl chr11:43,040,704...43,153,112
|
|
| G
|
Atp11c
|
ATPase, class VI, type 11C
|
affects expression
|
ISO
|
Lead affects the expression of ATP11C mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr X:59,268,643...59,450,041
Ensembl chr X:59,268,650...59,636,304
|
|
| G
|
Atp13a2
|
ATPase type 13A2
|
affects expression
|
ISO
|
Lead affects the expression of ATP13A2 mRNA
|
CTD |
PMID:28903495 |
|
NCBI chr 4:140,711,812...140,734,641
Ensembl chr 4:140,714,184...140,734,641
|
|
| G
|
Atp1a1
|
ATPase, Na+/K+ transporting, alpha 1 polypeptide
|
affects expression increases expression
|
ISO
|
Lead affects the expression of ATP1A1 mRNA Lead results in increased expression of ATP1A1 protein
|
CTD |
PMID:21364929 PMID:28903495 |
|
NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000
|
|
| G
|
Atp1a3
|
ATPase, Na+/K+ transporting, alpha 3 polypeptide
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affects expression
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ISO
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Lead affects the expression of ATP1A3 mRNA
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CTD |
PMID:28903495 |
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NCBI chr 7:24,677,592...24,705,338
Ensembl chr 7:24,677,592...24,705,383
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| G
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Atp1b1
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ATPase, Na+/K+ transporting, beta 1 polypeptide
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affects expression
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ISO
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Lead affects the expression of ATP1B1 mRNA
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CTD |
PMID:28903495 |
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NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924
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| G
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Atp1b2
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ATPase, Na+/K+ transporting, beta 2 polypeptide
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affects expression
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ISO
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Lead affects the expression of ATP1B2 mRNA
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CTD |
PMID:28903495 |
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NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768
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| G
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Atp2b3
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ATPase, Ca++ transporting, plasma membrane 3
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affects expression
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ISO
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Lead affects the expression of ATP2B3 mRNA
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CTD |
PMID:28903495 |
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NCBI chr X:72,546,356...72,632,267
Ensembl chr X:72,546,692...72,614,611
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| G
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Atp2b4
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ATPase, Ca++ transporting, plasma membrane 4
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affects splicing
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ISO
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Lead affects the splicing of ATP2B4 mRNA
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CTD |
PMID:28903495 |
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NCBI chr 1:133,630,416...133,728,755
Ensembl chr 1:133,627,195...133,728,779
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| G
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Atp2c1
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ATPase, Ca++-sequestering
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affects expression
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ISO
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Lead affects the expression of ATP2C1 mRNA
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CTD |
PMID:28903495 |
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NCBI chr 9:105,288,561...105,398,456
Ensembl chr 9:105,280,738...105,404,518
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| G
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Atp5f1b
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ATP synthase F1 subunit beta
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decreases expression
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ISO
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Lead results in decreased expression of ATP5F1B mRNA
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CTD |
PMID:19921347 |
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NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260
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| G
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Atp5f1c
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ATP synthase F1 subunit gamma
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affects splicing
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ISO
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Lead affects the splicing of ATP5F1C mRNA
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CTD |
PMID:28903495 |
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NCBI chr 2:10,060,841...10,085,321
Ensembl chr 2:10,060,827...10,085,321
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| G
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Atp5mc2
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ATP synthase membrane subunit c locus 2
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affects expression
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ISO
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Lead affects the expression of ATP5MC2 mRNA
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CTD |
PMID:28903495 |
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NCBI chr15:102,571,303...102,579,482
Ensembl chr15:102,571,299...102,580,787
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| G
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Atp5po
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ATP synthase peripheral stalk subunit OSCP
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affects expression
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ISO
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Lead affects the expression of ATP5PO mRNA
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CTD |
PMID:28903495 |
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NCBI chr16:91,722,111...91,728,518
Ensembl chr16:91,722,102...91,728,575 Ensembl chr16:91,722,102...91,728,575
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| G
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Atp6ap2
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ATPase, H+ transporting, lysosomal accessory protein 2
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decreases expression affects expression
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ISO
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Lead results in decreased expression of ATP6AP2 mRNA Lead affects the expression of ATP6AP2 mRNA
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CTD |
PMID:19921347 PMID:28903495 |
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NCBI chr X:12,453,998...12,483,290
Ensembl chr X:12,454,040...12,483,288
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| G
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Atp6v0a1
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ATPase, H+ transporting, lysosomal V0 subunit A1
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affects expression
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ISO
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Lead affects the expression of ATP6V0A1 mRNA
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CTD |
PMID:28903495 |
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NCBI chr11:100,899,262...100,954,545
Ensembl chr11:100,900,278...100,954,545
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| G
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Atp6v0a2
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ATPase, H+ transporting, lysosomal V0 subunit A2
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affects expression
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ISO
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Lead affects the expression of ATP6V0A2 mRNA
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CTD |
PMID:28903495 |
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NCBI chr 5:124,767,117...124,801,519
Ensembl chr 5:124,766,641...124,801,519
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| G
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Atp6v1g2
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ATPase, H+ transporting, lysosomal V1 subunit G2
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affects expression multiple interactions
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ISO
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Lead affects the expression of ATP6V1G2 mRNA [lead acetate results in increased abundance of Lead] which results in increased expression of ATP6V1G2 mRNA
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CTD |
PMID:28903495 PMID:36642386 |
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NCBI chr17:35,453,910...35,457,743
Ensembl chr17:35,452,636...35,457,743
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| G
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Atp7a
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ATPase, copper transporting, alpha polypeptide
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multiple interactions
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EXP
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[[cupric chloride results in increased abundance of Copper] co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of ATP7A protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of ATP7A protein
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CTD |
PMID:40010429 |
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NCBI chr X:105,070,830...105,171,766
Ensembl chr X:105,070,882...105,168,532
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| G
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Atp7b
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ATPase, copper transporting, beta polypeptide
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multiple interactions affects expression
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EXP ISO
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[[cupric chloride results in increased abundance of Copper] co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of ATP7B protein; [lead acetate results in increased abundance of Lead] which results in decreased expression of ATP7B protein Lead affects the expression of ATP7B mRNA
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CTD |
PMID:28903495 PMID:40010429 |
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NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321
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| G
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Atp8b1
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ATPase, class I, type 8B, member 1
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decreases expression
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ISO
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Lead results in decreased expression of ATP8B1 mRNA
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CTD |
PMID:19921347 |
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NCBI chr18:64,662,050...64,794,342
Ensembl chr18:64,662,038...64,794,338
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| G
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Atp9a
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ATPase, class II, type 9A
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affects expression
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ISO
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Lead affects the expression of ATP9A mRNA
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CTD |
PMID:28903495 |
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NCBI chr 2:168,476,358...168,584,290
Ensembl chr 2:168,476,358...168,584,329
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| G
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Atxn1
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ataxin 1
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affects expression
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ISO
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Lead affects the expression of ATXN1 mRNA
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CTD |
PMID:28903495 |
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NCBI chr13:45,703,231...46,118,467
Ensembl chr13:45,703,231...46,118,484
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| G
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Atxn2
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ataxin 2
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affects splicing
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ISO
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Lead affects the splicing of ATXN2 mRNA
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CTD |
PMID:28903495 |
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NCBI chr 5:121,849,794...121,954,372
Ensembl chr 5:121,849,400...121,954,556
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| G
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Auts2
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autism susceptibility candidate 2
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affects splicing
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ISO
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Lead affects the splicing of AUTS2 mRNA
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CTD |
PMID:28903495 |
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NCBI chr 5:131,466,171...132,572,059
Ensembl chr 5:131,466,171...132,572,183
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| G
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Aven
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apoptosis, caspase activation inhibitor
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affects expression
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ISO
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Lead affects the expression of AVEN mRNA
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CTD |
PMID:28903495 |
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NCBI chr 2:112,323,231...112,461,598
Ensembl chr 2:112,323,309...112,464,918
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| G
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Azgp1
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alpha-2-glycoprotein 1, zinc
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affects binding
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ISO
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AZGP1 protein binds to Lead
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CTD |
PMID:23896426 |
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NCBI chr 5:137,979,783...137,988,495
Ensembl chr 5:137,979,782...137,988,495
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| G
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B2m
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beta-2 microglobulin
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affects expression multiple interactions
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ISO
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Lead affects the expression of B2M mRNA [Metals, Heavy results in increased abundance of Lead] which results in increased secretion of B2M protein
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CTD |
PMID:28903495 PMID:39357351 |
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NCBI chr 2:121,978,168...121,983,563
Ensembl chr 2:121,978,167...121,983,564
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| G
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B3galnt1
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UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1
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affects splicing
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ISO
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Lead affects the splicing of B3GALNT1 mRNA
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CTD |
PMID:28903495 |
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NCBI chr 3:69,481,252...69,506,305
Ensembl chr 3:69,481,491...69,506,293
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