inorganic peroxide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	inorganic peroxide	go back to main search page
Accession:	CHEBI:24837	browse the term
Definition:	Compounds of structure ROOR' in which R and R' are inorganic groups.
Synonyms:	related_synonym:	inorganic peroxides

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Genes (48)

hydrogen peroxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 7 family member A1

decreases activity
multiple interactions

Hydrogen Peroxide results in decreased activity of ALDH7A1 protein
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]; Mercaptoethanol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]; NAD promotes the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]

NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,969...129,709,705

G

ATR serine/threonine kinase

multiple interactions
decreases expression

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATR mRNA]

NCBI chr13:83,175,515...83,289,986
Ensembl chr13:83,174,824...83,289,989

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]

PMID:37706587 PMID:38438008

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

multiple interactions
decreases expression

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 mRNA]

PMID:37706587 PMID:38438008

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

BCL3 transcription coactivator

decreases expression
multiple interactions

Hydrogen Peroxide results in decreased expression of BCL3 mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL3 mRNA]

NCBI chr 6:51,256,033...51,264,923
Ensembl chr 6:51,256,033...51,265,351

G

caspase 3

multiple interactions
increases expression
increases activity

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]; Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]

PMID:15191356 PMID:37706587 PMID:38438008

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

catalase

decreases response to substance
multiple interactions

CAT results in decreased susceptibility to Hydrogen Peroxide
CAT protein inhibits the reaction [Paraquat results in increased abundance of Hydrogen Peroxide]

PMID:11039594 PMID:18086661

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

C-C motif chemokine ligand 20

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of CCL20 mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of CCL20 mRNA]

NCBI chr15:129,172,743...129,176,069

G

cyclin E1

multiple interactions
increases expression

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of CCNE1 mRNA]

NCBI chr 6:39,919,541...39,933,224
Ensembl chr 6:39,919,624...39,933,363

G

claudin 1

decreases expression
multiple interactions

Hydrogen Peroxide results in decreased expression of CLDN1 mRNA; Hydrogen Peroxide results in decreased expression of CLDN1 protein
SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 protein]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 protein]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

C-X-C motif chemokine ligand 8

increases expression

Hydrogen Peroxide results in increased expression of CXCL8 mRNA

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

dual specificity phosphatase 1

multiple interactions
increases expression

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of DUSP1 mRNA]

NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086

G

dual specificity phosphatase 10

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of DUSP10 mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of DUSP10 mRNA]

NCBI chr10:10,866,446...10,905,852
Ensembl chr10:10,866,448...10,905,857

G

endothelin 1

multiple interactions
increases expression

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]

NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348

G

epidermal growth factor receptor

multiple interactions
decreases expression

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in decreased expression of EGFR mRNA]

NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589

G

fibroblast growth factor 18

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of FGF18 mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of FGF18 mRNA]

NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,759,791

G

fibroblast growth factor 8

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of FGF8 mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of FGF8 mRNA]

NCBI chr14:112,808,215...112,814,225
Ensembl chr14:112,808,162...112,814,248

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of FOS mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of FOS mRNA]

PMID:18086661 PMID:37706587

NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554

G

growth arrest and DNA damage inducible beta

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of GADD45B mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of GADD45B mRNA]

NCBI chr 2:76,107,928...76,111,458
Ensembl chr 2:76,107,929...76,111,479

G

growth arrest and DNA damage inducible gamma

multiple interactions
increases expression

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of GADD45G mRNA]

NCBI chr14:1,166,000...1,167,538
Ensembl chr14:1,165,982...1,167,529

G

heat shock protein family A (Hsp70) member 1 like

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of HSPA1L mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA1L mRNA]

NCBI chr 7:23,909,960...23,938,678
Ensembl chr 7:23,910,079...23,914,517

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of HSPA5 protein
Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein]; nimesulide inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein]

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

insulin like growth factor 1 receptor

decreases expression
multiple interactions

Hydrogen Peroxide results in decreased expression of IGF1R mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in decreased expression of IGF1R mRNA]

NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058

G

interleukin 15

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of IL15 mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of IL15 mRNA]

NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,321...85,678,461

G

interleukin 6

multiple interactions
increases expression

SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of JUN mRNA; Hydrogen Peroxide results in increased expression of JUN protein
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN mRNA]; Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein]

NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of JUNB mRNA]

NCBI chr 2:66,214,086...66,219,435
Ensembl chr 2:66,214,138...66,217,002

G

lactate dehydrogenase A

multiple interactions
increases activity

SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased activity of LDHA protein]; theanine inhibits the reaction [Hydrogen Peroxide results in increased activity of LDHA protein]

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

LIF interleukin 6 family cytokine

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of LIF mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of LIF mRNA]

NCBI chr14:47,221,540...47,239,513
Ensembl chr14:47,221,560...47,238,749

G

interleukin-1 beta-like

multiple interactions
increases expression

SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B protein]; theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B mRNA]

G

mitogen-activated protein kinase kinase 4

multiple interactions

[Oleanolic Acid co-treated with Hydrogen Peroxide] results in increased expression of MAP2K4 mRNA

NCBI chr12:56,402,029...56,516,217
Ensembl chr12:56,402,075...56,516,238

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

[Oleanolic Acid co-treated with Hydrogen Peroxide] results in increased expression of MAP3K5 mRNA

NCBI chr 1:27,380,143...27,600,500
Ensembl chr 1:27,380,142...27,600,493

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]

PMID:11325585 PMID:21798251

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 14

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of MAPK14 protein
theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK14 protein]

NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031

G

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein
3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]

PMID:11325585 PMID:21798251

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitogen-activated protein kinase 8

increases phosphorylation

Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein

PMID:11325585 PMID:18086661

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

mitogen-activated protein kinase 9

increases phosphorylation

Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein

NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100

G

matrix metallopeptidase 14

multiple interactions
increases expression

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP14 mRNA]

NCBI chr 7:76,174,502...76,185,931
Ensembl chr 7:76,172,971...76,185,928

G

NFKB inhibitor alpha

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of NFKBIA mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of NFKBIA mRNA]

NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277

G

occludin

decreases expression
multiple interactions

Hydrogen Peroxide results in decreased expression of OCLN mRNA; Hydrogen Peroxide results in decreased expression of OCLN protein
SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN protein]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

protein phosphatase, Mg2+/Mn2+ dependent 1D

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of PPM1D mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of PPM1D mRNA]

NCBI chr12:37,485,601...37,536,159
Ensembl chr12:37,485,588...37,536,146

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation
multiple interactions

Hydrogen Peroxide results in increased phosphorylation of RELA protein
theanine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

suppressor of cytokine signaling 3

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of SOCS3 mRNA
Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of SOCS3 mRNA]

NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,009

G

superoxide dismutase 1

multiple interactions

[sodium arsenite results in increased activity of SOD1 protein] which results in increased abundance of Hydrogen Peroxide

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

tight junction protein 1

multiple interactions
decreases expression

SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 protein]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 protein]
Hydrogen Peroxide results in decreased expression of TJP1 mRNA; Hydrogen Peroxide results in decreased expression of TJP1 protein

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

increases expression
multiple interactions

Hydrogen Peroxide results in increased expression of TNF mRNA
SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF protein]; theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]

PMID:22083491 PMID:38438008

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

G

TNF alpha induced protein 3

multiple interactions
increases expression

Oleanolic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFAIP3 mRNA]

NCBI chr 1:26,474,158...26,489,771
Ensembl chr 1:26,473,938...26,489,822

G

xanthine dehydrogenase

multiple interactions

[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Hydrogen Peroxide

NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	5151
chemical entity	5151
molecular entity	5150
inorganic molecular entity	5050
inorganic oxide	60
inorganic peroxide	48
chlorine peroxide	0
hydrogen peroxide +	48
peroxybis(sulfanide)	0
Path 2
Term	Annotations
CHEBI ontology	5151
subatomic particle	5142
composite particle	5142
hadron	5142
baryon	5142
nucleon	5142
atomic nucleus	5142
atom	5142
main group element atom	5115
p-block element atom	5112
chalcogen	5009
oxygen atom	4978
oxygen molecular entity	4978
oxide	102
inorganic oxide	60
inorganic peroxide	48
chlorine peroxide	0
hydrogen peroxide +	48
peroxybis(sulfanide)	0

paths to the root