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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:imine
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Accession:CHEBI:24783 term browser browse the term
Definition:Compounds having the structure RN=CR2 (R = H, hydrocarbyl). Thus analogues of aldehydes or ketones, having NR doubly bonded to carbon; aldimines have the structure RCH=NR, ketimines have the structure R'2C=NR (where R' is not H). Imines include azomethines and Schiff bases. Imine is used as a suffix in systematic nomenclature to denote the C=NH group excluding the carbon atom.
Synonyms:related_synonym: Formula=CNR3;   SMILES=[*]\\C([*])=N\\[*];   imines


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2,6-dichloroindophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in decreased expression of BCL2L1 mRNA CTD PMID:21034357 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CCL4 mRNA CTD PMID:21034357 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A protein CTD PMID:21034357 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] CTD PMID:19635391 NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488 		JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CRYAB mRNA CTD PMID:21034357 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CXCL10 mRNA CTD PMID:21034357 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EGR1 mRNA CTD PMID:21034357 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EPHX2 mRNA CTD PMID:21034357 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of FASLG mRNA CTD PMID:21034357 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GADD45A mRNA CTD PMID:21034357 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA CTD PMID:21034357 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GSTM3 mRNA CTD PMID:21034357 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 protein CTD PMID:21034357 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A protein CTD PMID:21034357 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA2 mRNA CTD PMID:21034357 NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 protein CTD PMID:21034357 NCBI chr13:85,805,911...85,807,052 JBrowse link
G Lta lymphotoxin alpha multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of LTA mRNA CTD PMID:21034357 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of NOS2 mRNA CTD PMID:21034357 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases response to substance
increases reduction 		ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in decreased expression of BCL2L1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CCL4 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CDKN1A protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CRYAB mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CXCL10 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EGR1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of EPHX2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of FASLG mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GADD45A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GDF15 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GSTM3 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HMOX1 protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA1A protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of HSPA6 protein; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of LTA mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of NOS2 mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of TNF mRNA; [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased phosphorylation of TP53 protein; Carbamazepine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Diclofenac inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Dicumarol inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; Mefenamic Acid inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]; NQO1 protein inhibits the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; NQO1 protein polymorphism promotes the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; Tacrine inhibits the reaction [NQO1 protein results in increased reduction of 2,6-Dichloroindophenol]
NQO1 protein polymorphism results in increased susceptibility to 2,6-Dichloroindophenol 		CTD PMID:21034357 PMID:29281794 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions
increases reduction 		ISO [NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of 2,6-Dichloroindophenol; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of 2,6-Dichloroindophenol; resveratrol inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol] CTD PMID:20399199 PMID:29281794 NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]] CTD PMID:19635391 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] CTD PMID:19635391 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of TNF mRNA CTD PMID:21034357 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased phosphorylation of TP53 protein CTD PMID:21034357 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
5,5-dimethyl-1-pyrroline N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO [NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein CTD PMID:20348042 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; [[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione] which results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide] which results in increased expression of MPO protein modified form; [Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide] CTD PMID:20199096 PMID:28754375 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO [NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein CTD PMID:20348042 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837 		JBrowse link
Bandrowski's base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 increases expression ISO Bandrowski's base results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Bandrowski's base results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO Bandrowski's base results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO Bandrowski's base results in increased expression of AKR1C3 mRNA CTD PMID:20566472 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438 		JBrowse link
G Cat catalase increases expression ISO Bandrowski's base results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 affects expression ISO Bandrowski's base affects the expression of CCL17 mRNA CTD PMID:18202158 NCBI chr19:10,208,120...10,218,340
Ensembl chr19:10,208,120...10,209,895 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 affects expression ISO Bandrowski's base affects the expression of CCL22 mRNA CTD PMID:18202158 NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 affects expression ISO Bandrowski's base affects the expression of CCL4 mRNA CTD PMID:18202158 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 affects expression
increases expression 		ISO Bandrowski's base affects the expression of CCR7 mRNA
Bandrowski's base results in increased expression of CCR7 protein 		CTD PMID:18202158 PMID:19665512 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501 		JBrowse link
G Cd80 Cd80 molecule increases expression ISO Bandrowski's base results in increased expression of CD80 protein CTD PMID:31958493 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540 		JBrowse link
G Cd86 CD86 molecule affects expression
multiple interactions
increases expression 		ISO Bandrowski's base affects the expression of CD86 mRNA
MIR146A affects the reaction [Bandrowski's base results in increased expression of CD86 protein]; PRKCB protein affects the reaction [Bandrowski's base results in increased expression of CD86 protein] 		CTD PMID:18202158 PMID:19665512 PMID:21742781 PMID:31958493 PMID:37326882 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 affects expression ISO Bandrowski's base affects the expression of CXCR4 mRNA CTD PMID:18202158 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Fech ferrochelatase increases expression ISO Bandrowski's base results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:60,215,325...60,248,525
Ensembl chr18:60,215,325...60,249,546 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Bandrowski's base results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:105,072,858...105,074,705
Ensembl chr  X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO Bandrowski's base results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Bandrowski's base results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Bandrowski's base results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Bandrowski's base results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Bandrowski's base results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Bandrowski's base results in increased expression of HMOX1 mRNA CTD PMID:20566472 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
affects expression 		ISO Bandrowski's base results in increased expression of ICAM1 protein
Bandrowski's base affects the expression of ICAM1 mRNA 		CTD PMID:18202158 PMID:21742781 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Bandrowski's base results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147 		JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO Bandrowski's base results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:106,401,633...106,410,159 JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO Bandrowski's base results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr12:19,948,473...19,970,351
Ensembl chr12:19,948,476...19,959,192 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO Bandrowski's base results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Bandrowski's base results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875 		JBrowse link
G Mir146a microRNA 146a multiple interactions ISO MIR146A affects the reaction [Bandrowski's base results in increased expression of CD86 protein] CTD PMID:37326882 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Mir155 microRNA 155 increases expression ISO Bandrowski's base results in increased expression of MIR155 mRNA CTD PMID:32939143 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178 		JBrowse link
G Mir21 microRNA 21 decreases expression ISO Bandrowski's base results in decreased expression of MIR21 mRNA CTD PMID:32939143 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Bandrowski's base results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO Bandrowski's base results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029 		JBrowse link
G Ppia peptidylprolyl isomerase A affects expression ISO Bandrowski's base affects the expression of PPIA mRNA CTD PMID:18202158 NCBI chr14:85,491,223...85,496,884
Ensembl chr14:85,492,484...85,497,115 		JBrowse link
G Prkcb protein kinase C, beta increases expression
multiple interactions 		ISO Bandrowski's base results in increased expression of PRKCB protein
PRKCB protein affects the reaction [Bandrowski's base results in increased expression of CD86 protein] 		CTD PMID:31958493 PMID:37326882 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740 		JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO Bandrowski's base results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Bandrowski's base results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Bandrowski's base results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sod3 superoxide dismutase 3 increases expression ISO Bandrowski's base results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Bandrowski's base results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A affects expression ISO Bandrowski's base affects the expression of TNFRSF1A mRNA CTD PMID:18202158 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
G Txn2 thioredoxin 2 increases expression ISO Bandrowski's base results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Bandrowski's base results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO Bandrowski's base results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr11:96,024,321...96,072,475
Ensembl chr11:96,024,324...96,072,475 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Bandrowski's base results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
N-acetyl-1,4-benzoquinone imine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions 		ISO N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA; N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein] 		CTD PMID:28286204 PMID:29355602 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adarb2 adenosine deaminase RNA specific B2 affects response to substance ISO ADARB2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:61,750,437...62,300,984
Ensembl chr17:66,665,506...67,210,749 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule affects response to substance ISO ALCAM gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:61,804,932...62,005,250
Ensembl chr11:61,805,049...62,006,876 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 affects response to substance ISO ALDH1A3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of BMP2 mRNA CTD PMID:28286204 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760 		JBrowse link
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 affects response to substance ISO BPNT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:22,573,241...22,600,126
Ensembl chr 5:22,570,165...22,600,126 		JBrowse link
G C11h3orf38 similar to human chromosome 3 open reading frame 38 affects response to substance ISO C3ORF38 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:2,483,983...2,488,631
Ensembl chr11:15,783,138...15,935,152 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H affects response to substance ISO CACNA1H gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,894,641...14,952,771 		JBrowse link
G Cald1 caldesmon 1 affects response to substance ISO CALD1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:64,232,906...64,414,085
Ensembl chr 4:64,233,171...64,414,085 		JBrowse link
G Ccdc25 coiled-coil domain containing 25 affects response to substance ISO CCDC25 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr15:40,055,368...40,087,758
Ensembl chr15:44,230,940...44,265,236 		JBrowse link
G Cd9 CD9 molecule affects response to substance ISO CD9 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:159,942,560...159,975,444 		JBrowse link
G Cep44 centrosomal protein 44 affects response to substance ISO CEP44 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:33,711,548...33,733,226
Ensembl chr16:38,721,513...38,741,614 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions 		ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA] 		CTD PMID:28286204 PMID:29355602 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A2 mRNA CTD PMID:28286204 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions 		ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA] 		CTD PMID:28286204 PMID:29355602 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232 		JBrowse link
G Cpa6 carboxypeptidase A6 affects response to substance ISO CPA6 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:13,309,660...13,671,429
Ensembl chr 5:13,309,660...13,671,429 		JBrowse link
G Cst5 cystatin D affects response to substance ISO CST5 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:158,033,791...158,038,345
Ensembl chr 3:158,033,791...158,038,345 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases abundance 		ISO CYP1A2 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP1A2 protein results in increased abundance of N-acetyl-4-benzoquinoneimine 		CTD PMID:19679878 PMID:24661219 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases abundance ISO CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases abundance
increases chemical synthesis 		ISO
EXP 		CYP2E1 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 protein results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 results in increased chemical synthesis of N-acetyl-4-benzoquinoneimine 		CTD PMID:19679878 PMID:20566340 PMID:24661219 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases abundance ISO CYP3A4 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 affects response to substance ISO DMRT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:232,569,179...232,667,646
Ensembl chr 1:232,569,072...232,668,370 		JBrowse link
G Dnttip1 deoxynucleotidyltransferase, terminal, interacting protein 1 affects response to substance ISO DNTTIP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:173,901,070...173,924,742
Ensembl chr 3:173,900,945...173,925,098 		JBrowse link
G Dsc3 desmocollin 3 affects response to substance ISO DSC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr18:11,654,833...11,688,871
Ensembl chr18:11,653,832...11,688,871 		JBrowse link
G Etnk2 ethanolamine kinase 2 affects response to substance ISO ETNK2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:47,362,964...47,381,100
Ensembl chr13:47,363,060...47,381,100 		JBrowse link
G Fbxo39 F-box protein 39 affects response to substance ISO FBXO39 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:57,428,259...57,433,468
Ensembl chr10:57,430,848...57,433,467 		JBrowse link
G Frk fyn-related Src family tyrosine kinase affects response to substance ISO FRK gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:39,820,441...39,926,065
Ensembl chr20:39,820,295...39,926,362 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
affects response to substance 		ISO [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine
GPX1 protein affects the susceptibility to N-acetyl-4-benzoquinoneimine 		CTD PMID:16636302 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
multiple interactions
increases glutathionylation
increases metabolic processing 		ISO
EXP 		GSTP1 protein polymorphism affects the metabolism of N-acetyl-4-benzoquinoneimine metabolite
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
GSTP1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine 		CTD PMID:24185126 PMID:24552538 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Hdac4 histone deacetylase 4 affects response to substance ISO HDAC4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:99,955,116...100,197,637 		JBrowse link
G Hid1 HID1 domain containing affects response to substance ISO HID1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:101,088,526...101,109,011
Ensembl chr10:101,088,526...101,109,011 		JBrowse link
G Il23r interleukin 23 receptor affects response to substance ISO IL23R gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:97,910,230...98,003,759
Ensembl chr 4:97,909,972...98,004,110 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 affects response to substance ISO KCNJ3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:60,354,146...60,518,104 		JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 affects response to substance ISO KCNU1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:72,844,692...72,932,216
Ensembl chr16:72,844,712...72,932,334 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
affects metabolic processing 		ISO KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein 		CTD PMID:18785192 PMID:19246624 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Lama4 laminin subunit alpha 4 affects response to substance ISO LAMA4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:43,946,898...44,087,972
Ensembl chr20:43,946,898...44,087,972 		JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha affects response to substance ISO LMX1A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:82,367,493...82,511,157
Ensembl chr13:82,367,933...82,511,154 		JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 affects response to substance ISO MAGI2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:15,278,518...16,762,427
Ensembl chr 4:15,278,518...16,762,199 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK1 protein CTD PMID:28286204 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK3 protein CTD PMID:28286204 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 affects response to substance ISO MCTP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:7,798,968...8,493,596
Ensembl chr 2:7,803,382...8,493,596 		JBrowse link
G Mfsd4a major facilitator superfamily domain containing 4A affects response to substance ISO MFSD4A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:46,015,321...46,062,633
Ensembl chr13:46,021,659...46,062,633 		JBrowse link
G Mir135a2 microRNA 135a-2 affects response to substance ISO MIR135A2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:28,499,166...28,499,265 JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of MMP2 mRNA CTD PMID:28286204 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mtus2 microtubule associated scaffold protein 2 affects response to substance ISO MTUS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr12:11,742,713...12,115,798
Ensembl chr12:11,742,713...11,787,314 		JBrowse link
G Neb nebulin affects response to substance ISO NEB gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:57,022,822...57,220,752
Ensembl chr 3:57,022,822...57,220,709 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions
increases activity 		ISO N-acetyl-4-benzoquinoneimine affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine results in increased activity of NFE2L2 protein 		CTD PMID:18785192 PMID:19246624 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nhlrc3 NHL repeat containing 3 affects response to substance ISO NHLRC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:139,678,127...139,692,423
Ensembl chr 2:139,679,866...139,692,691 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases reduction
increases metabolic processing
increases expression 		ISO KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]; NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
NQO1 protein results in increased reduction of N-acetyl-4-benzoquinoneimine 		CTD PMID:17188792 PMID:18785192 PMID:19246624 PMID:24552538 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of N-acetyl-4-benzoquinoneimine; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of N-acetyl-4-benzoquinoneimine] CTD PMID:29281794 NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662 		JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 affects response to substance ISO PCBD2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:8,850,349...8,902,420 JBrowse link
G Pvt1 Pvt1 oncogene affects response to substance ISO PVT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:95,545,916...95,769,306 JBrowse link
G Rab3il1 RAB3A interacting protein-like 1 affects response to substance ISO RAB3IL1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:216,071,043...216,107,609
Ensembl chr 1:216,071,084...216,107,609 		JBrowse link
G Rap1gap2 RAP1 GTPase activating protein 2 affects response to substance ISO RAP1GAP2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:59,255,400...59,472,536
Ensembl chr10:59,753,822...59,970,887 		JBrowse link
G Slc39a11 solute carrier family 39, member 11 affects response to substance ISO SLC39A11 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:98,775,155...99,196,302
Ensembl chr10:98,776,525...99,107,368 		JBrowse link
G Slit2 slit guidance ligand 2 affects response to substance ISO SLIT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:66,829,661...67,168,517
Ensembl chr14:66,829,661...67,167,146 		JBrowse link
G Snx16 sorting nexin 16 affects response to substance ISO SNX16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:93,242,779...93,265,048
Ensembl chr 2:93,243,494...93,265,050 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:16636302 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Spag16 sperm associated antigen 16 affects response to substance ISO SPAG16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 9:78,782,596...79,702,265
Ensembl chr 9:78,782,614...78,877,630 		JBrowse link
G Stab1 stabilin 1 affects response to substance ISO STAB1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:6,336,871...6,367,374
Ensembl chr16:6,336,871...6,364,579 		JBrowse link
G Syne3 spectrin repeat containing, nuclear envelope family member 3 affects response to substance ISO SYNE3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:129,637,644...129,729,542
Ensembl chr 6:129,641,123...129,729,509 		JBrowse link
G Tac1 tachykinin, precursor 1 increases secretion EXP N-acetyl-4-benzoquinoneimine results in increased secretion of TAC1 protein CTD PMID:20720158 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of TGFB1 mRNA CTD PMID:28286204 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of TIMP1 mRNA CTD PMID:28286204 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO N-acetyl-4-benzoquinoneimine results in decreased activity of TOP2A protein CTD PMID:15035644 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Tpd52l1 TPD52 like 1 affects response to substance ISO TPD52L1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:27,991,114...28,109,767
Ensembl chr 1:27,991,131...28,110,158 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
affects response to substance
multiple interactions 		ISO
EXP 		N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein
TRPA1 affects the susceptibility to N-acetyl-4-benzoquinoneimine
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein] 		CTD PMID:20720158 NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity
multiple interactions 		EXP N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein
Glutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein] 		CTD PMID:24661219 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A affects response to substance ISO UBASH3A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:9,292,819...9,336,036
Ensembl chr20:9,287,590...9,344,772 		JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 affects response to substance ISO UBE2E2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr15:9,411,067...9,688,731
Ensembl chr15:9,411,539...9,712,661 		JBrowse link
G Vwc2 von Willebrand factor C domain containing 2 affects response to substance ISO VWC2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:89,897,543...90,038,732
Ensembl chr14:89,897,887...90,032,188 		JBrowse link
G Wfdc3 WAP four-disulfide core domain 3 affects response to substance ISO WFDC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:173,884,206...173,898,294
Ensembl chr 3:173,884,206...173,898,294 		JBrowse link
pararosaniline free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO pararosaniline results in decreased activity of BCHE protein CTD PMID:16036213 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO pararosaniline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression
decreases activity 		ISO pararosaniline results in decreased expression of NR3C1 protein
pararosaniline results in decreased activity of NR3C1 protein 		CTD PMID:19255438 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
sirtinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO sirtinol inhibits the reaction [S-allylcysteine results in increased phosphorylation of ACACA protein] CTD PMID:23465592 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR mutant form inhibits the reaction [sirtinol results in increased expression of CYP1A1 mRNA]; AHR mutant form inhibits the reaction [sirtinol results in increased expression of NQO1 mRNA] CTD PMID:22495798 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]] CTD PMID:26450947 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] CTD PMID:24254769 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; sirtinol promotes the reaction [cudraflavone B results in increased expression of BAX protein] 		CTD PMID:23881456 PMID:25665036 PMID:26450947 PMID:28851138 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; sirtinol promotes the reaction [cudraflavone B results in decreased expression of BCL2 protein] CTD PMID:23881456 PMID:28851138 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP 		sirtinol inhibits the reaction [Resveratrol results in increased activity of CASP3 protein]; sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]]; sirtinol promotes the reaction [cudraflavone B results in increased activity of CASP3 protein]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; sirtinol results in increased cleavage of and results in increased activity of CASP3 protein 		CTD PMID:20697895 PMID:23881456 PMID:24889822 PMID:25665036 PMID:26251326 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in increased activity of CASP9 protein] CTD PMID:20697895 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]] CTD PMID:20531350 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO sirtinol results in increased expression of CCL20 mRNA CTD PMID:22385246 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO sirtinol promotes the reaction [TNF protein results in increased expression of CD40 mRNA] CTD PMID:22717288 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions 		ISO sirtinol results in increased expression of CDKN1A mRNA; sirtinol results in increased expression of CDKN1A protein
sirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1A protein] 		CTD PMID:22495798 PMID:23881456 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO sirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1B protein] CTD PMID:23881456 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Col10a1 collagen type X alpha 1 chain decreases expression ISO sirtinol results in decreased expression of COL10A1 protein CTD PMID:26251326 NCBI chr20:39,737,536...39,744,518
Ensembl chr20:39,716,822...39,751,440 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO sirtinol results in decreased expression of COL1A1 protein CTD PMID:26251326 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression ISO sirtinol results in decreased expression of COL2A1 protein CTD PMID:26251326 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627 		JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression EXP sirtinol results in increased expression of CYBA mRNA CTD PMID:23422569 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of CYBB protein]] CTD PMID:28851138 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions 		ISO sirtinol results in increased expression of CYP1A1 mRNA
AHR mutant form inhibits the reaction [sirtinol results in increased expression of CYP1A1 mRNA] 		CTD PMID:22495798 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO sirtinol inhibits the reaction [cilostazol affects the expression of EP300 protein]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]] CTD PMID:24254769 PMID:25665036 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO sirtinol promotes the reaction [TNF protein results in increased expression of F3 mRNA]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 protein] CTD PMID:20978007 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO [sirtinol results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA CTD PMID:22146233 NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions
increases acetylation 		ISO
EXP 		sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]
sirtinol results in increased acetylation of FOXO1 protein
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein] 		CTD PMID:24889822 PMID:25665036 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Gh1 growth hormone 1 multiple interactions
increases secretion
increases expression 		EXP sirtinol inhibits the reaction [resveratrol results in decreased secretion of GH1 protein]
sirtinol results in increased secretion of GH1 protein
sirtinol results in increased expression of GH1 mRNA 		CTD PMID:23292070 NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO sirtinol results in decreased expression of IGF1R mRNA CTD PMID:22495798 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO sirtinol results in increased expression of IGFBP3 mRNA CTD PMID:22495798 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]
sirtinol results in increased expression of IL1B mRNA 		CTD PMID:20531350 PMID:22385246 PMID:23973301 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Klf2 KLF transcription factor 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in increased expression of KLF2 mRNA] CTD PMID:19815564 NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,555,136...17,557,768 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression
multiple interactions 		ISO sirtinol results in decreased expression of KLK3 mRNA; sirtinol results in decreased expression of KLK3 protein
sirtinol inhibits the reaction [Estradiol results in increased expression of KLK3 mRNA] 		CTD PMID:22495798 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of MAPK1 protein CTD PMID:21745208 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of MAPK3 protein CTD PMID:21745208 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mir141 microRNA 141 multiple interactions EXP sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NOS1 protein]]; sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SNCA protein]] CTD PMID:33204711 NCBI chr 4:159,209,525...159,209,618 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP sirtinol inhibits the reaction [resveratrol results in decreased expression of MYC protein] CTD PMID:24395567 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nanog Nanog homeobox multiple interactions ISO sirtinol inhibits the reaction [cordycepin results in increased expression of NANOG mRNA] CTD PMID:36881089 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP sirtinol inhibits the reaction [resveratrol results in increased expression of NFE2L2 protein] CTD PMID:24395567 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases degradation ISO sirtinol results in increased degradation of NFKBIA protein CTD PMID:21745208 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO sirtinol results in decreased expression of NKX3-1 mRNA CTD PMID:22495798 NCBI chr15:50,883,661...50,886,253
Ensembl chr15:50,883,597...50,886,251 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NOS1 protein]] CTD PMID:33204711 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression 		EXP resveratrol inhibits the reaction [sirtinol results in increased expression of NOX4 mRNA] CTD PMID:23422569 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression 		ISO AHR mutant form inhibits the reaction [sirtinol results in increased expression of NQO1 mRNA] CTD PMID:22495798 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA] CTD PMID:26044878 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions EXP sirtinol inhibits the reaction [resveratrol results in decreased expression of PDK1 protein] CTD PMID:24395567 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of PDK4 protein]] CTD PMID:26450947 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased expression of PDPK1 protein]] CTD PMID:26450947 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO sirtinol inhibits the reaction [cordycepin results in increased expression of POU5F1 mRNA] CTD PMID:36881089 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP 		sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]
sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PPARGC1A protein]]
sirtinol inhibits the reaction [resveratrol results in increased expression of PPARGC1A protein] 		CTD PMID:24395567 PMID:25159133 PMID:28477916 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PRKN protein]] CTD PMID:28477916 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] CTD PMID:23257246 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO sirtinol promotes the reaction [cudraflavone B results in decreased phosphorylation of RB1 protein] CTD PMID:23881456 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases localization 		ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]]
sirtinol promotes the reaction [TNF protein results in increased acetylation of RELA protein]
sirtinol results in increased localization of RELA protein 		CTD PMID:21745208 PMID:22717288 PMID:23257246 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions
increases expression 		ISO sirtinol inhibits the reaction [SIRT1 protein binds to SHC1 promoter]
sirtinol results in increased expression of SHC1 mRNA; sirtinol results in increased expression of SHC1 protein 		CTD PMID:21778425 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914 		JBrowse link
G Sirt1 sirtuin 1 decreases activity
multiple interactions 		ISO
EXP 		sirtinol analog results in decreased activity of SIRT1 protein; sirtinol results in decreased activity of SIRT1 protein
sirtinol inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [Resveratrol results in increased expression of and results in increased activity of SIRT1 protein]
[sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Glucose; sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]
[sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein]; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Plant Extracts; [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Resveratrol; [sirtinol results in decreased activity of SIRT1 protein] which results in increased susceptibility to Hydrogen Peroxide; sirtinol inhibits the reaction [[Resveratrol co-treated with TNF protein] results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [cordycepin results in increased expression of SIRT1 mRNA]; sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 mRNA]; sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [SIRT1 protein binds to SHC1 promoter] 		CTD PMID:16302818 PMID:18681908 PMID:19288225 PMID:20370652 PMID:20531350 More... NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Sirt2 sirtuin 2 decreases activity ISO sirtinol analog results in decreased activity of SIRT2 protein; sirtinol results in decreased activity of SIRT2 protein CTD PMID:16302818 PMID:24998427 NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:93,181,224...93,204,499 		JBrowse link
G Smad1 SMAD family member 1 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of SMAD1 protein CTD PMID:21745208 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957 		JBrowse link
G Smad5 SMAD family member 5 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of SMAD5 protein CTD PMID:21745208 NCBI chr17:7,867,640...7,896,983
Ensembl chr17:7,871,984...7,890,992 		JBrowse link
G Smad9 SMAD family member 9 decreases phosphorylation ISO sirtinol results in decreased phosphorylation of SMAD9 protein CTD PMID:21745208 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:141,106,668...141,156,477 		JBrowse link
G Snca synuclein alpha multiple interactions EXP sirtinol affects the reaction [MIR141 mRNA affects the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SNCA protein]] CTD PMID:33204711 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions ISO sirtinol inhibits the reaction [cordycepin results in increased expression of SOX2 mRNA] CTD PMID:36881089 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP sirtinol inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]]; sirtinol promotes the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein] CTD PMID:24889822 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO sirtinol inhibits the reaction [S-allylcysteine results in decreased expression of SREBF1 protein] CTD PMID:23465592 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO
EXP 		sirtinol inhibits the reaction [[resveratrol co-treated with TNF protein] results in increased expression of SIRT1 protein]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]]; sirtinol inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 mRNA]; sirtinol promotes the reaction [TNF protein results in increased expression of F3 protein]
Sirtinol promotes the reactions [Lipopolysaccharide, acetate, acetaldehyde increases secretion of Tnf protein from Kupffer cells]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; sirtinol promotes the reaction [TNF protein results in increased acetylation of RELA protein]; sirtinol promotes the reaction [TNF protein results in increased expression of CD40 mRNA]
sirtinol results in increased expression of TNF mRNA 		CTD
RGD		 PMID:20978007 PMID:22385246 PMID:22717288 PMID:23257246 PMID:23973301 More... RGD:9585771 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein]; sirtinol promotes the reaction [arsenic disulfide results in increased expression of and results in increased phosphorylation of TP53 protein]; sirtinol promotes the reaction [cudraflavone B results in increased expression of TP53 protein]
sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]] 		CTD PMID:18298901 PMID:18681908 PMID:23881456 PMID:25665036 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of TRIM63 protein]] CTD PMID:25665036 PMID:26450947 NCBI chr 5:151,817,209...151,831,026
Ensembl chr 5:151,817,225...151,831,058 		JBrowse link
G Usp7 ubiquitin specific peptidase 7 multiple interactions ISO sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of USP7 protein]] CTD PMID:25665036 NCBI chr10:7,335,508...7,432,018
Ensembl chr10:7,367,604...7,432,013 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [sirtinol co-treated with cobaltous chloride] results in increased cleavage of VEGFA protein; sirtinol inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein] CTD PMID:22669716 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          carbon atom 20710
            organic molecular entity 20710
              imine 194
                1-pyrroline 0
                2,6-dichlorophenol-4-(2,3-dihydro-1,4-naphthoquinone imine) 0
                2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone 0
                2-\{5-amino-4-[cyano(imino)methyl]-1H-imidazol-1-yl\}-3-phenylpropanoic acid 0
                2-chloro-3-(3-methoxypropylimino)naphthalene-1,4-dione 0
                2-chloro-3-propan-2-yliminonaphthalene-1,4-dione 0
                2-hydroxy-5-[(1E)-(2-phenylethylidene)amino]-L-tyrosine 0
                2-methyl-1-pyrroline 0
                3,4-dihydroxy-5-(2-hydroxyethanimidoyl)oxolan-2-one 0
                3-methyl-4-[(4'-methyl[2,2'-bipyridin]-4-yl)imino]but-2-en-2-amine 0
                Hoffman's violet free base 0
                Methyl violet 2B free base 0
                N-[(E)-4-aminobutylidene]propane-1,3-diamine 0
                N-[(E)-\{[(Z)-2-amino-1,2-dicyanoethenyl]imino\}methyl]phenylalanine 0
                N-[3-(2-methoxyphenyl)imino-1,4-dioxo-2-naphthalenyl]acetamide 0
                SRS16-86 0
                Schiff base + 0
                acid fuchsin (free acid form) 0
                acridine red 3B free base 0
                acylimine + 0
                aldimine + 65
                alkali Blue G 0
                auramine O free base 0
                azaxylylene + 0
                azocarmine B free acid 0
                azocarmine G free acid 0
                clitidine 0
                dehydroglycine 0
                iminopiperidine + 0
                ketenimine 0
                ketimine + 73
                magenta II free base 0
                methyl blue free acid 0
                new fuchsin free base 0
                nitrone + 3
                pararosaniline free base 3
                pyrimidinimine + 0
                quinone imine + 133
                rosanilin free base 0
                spirit blue base 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      p-block molecular entity 20781
                        carbon group molecular entity 20715
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organonitrogen compound 19403
                                imine 194
                                  1-pyrroline 0
                                  2,6-dichlorophenol-4-(2,3-dihydro-1,4-naphthoquinone imine) 0
                                  2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone 0
                                  2-\{5-amino-4-[cyano(imino)methyl]-1H-imidazol-1-yl\}-3-phenylpropanoic acid 0
                                  2-chloro-3-(3-methoxypropylimino)naphthalene-1,4-dione 0
                                  2-chloro-3-propan-2-yliminonaphthalene-1,4-dione 0
                                  2-hydroxy-5-[(1E)-(2-phenylethylidene)amino]-L-tyrosine 0
                                  2-methyl-1-pyrroline 0
                                  3,4-dihydroxy-5-(2-hydroxyethanimidoyl)oxolan-2-one 0
                                  3-methyl-4-[(4'-methyl[2,2'-bipyridin]-4-yl)imino]but-2-en-2-amine 0
                                  Hoffman's violet free base 0
                                  Methyl violet 2B free base 0
                                  N-[(E)-4-aminobutylidene]propane-1,3-diamine 0
                                  N-[(E)-\{[(Z)-2-amino-1,2-dicyanoethenyl]imino\}methyl]phenylalanine 0
                                  N-[3-(2-methoxyphenyl)imino-1,4-dioxo-2-naphthalenyl]acetamide 0
                                  SRS16-86 0
                                  Schiff base + 0
                                  acid fuchsin (free acid form) 0
                                  acridine red 3B free base 0
                                  acylimine + 0
                                  aldimine + 65
                                  alkali Blue G 0
                                  auramine O free base 0
                                  azaxylylene + 0
                                  azocarmine B free acid 0
                                  azocarmine G free acid 0
                                  clitidine 0
                                  dehydroglycine 0
                                  iminopiperidine + 0
                                  ketenimine 0
                                  ketimine + 73
                                  magenta II free base 0
                                  methyl blue free acid 0
                                  new fuchsin free base 0
                                  nitrone + 3
                                  pararosaniline free base 3
                                  pyrimidinimine + 0
                                  quinone imine + 133
                                  rosanilin free base 0
                                  spirit blue base 0
paths to the root