secondary alpha-hydroxy ketone - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	secondary alpha-hydroxy ketone	go back to main search page
Accession:	CHEBI:2468	browse the term
Definition:	An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing one hydrogen and one organyl group. Secondary alpha-hydroxy ketones are also known as acyloins, and are formally derived from reductive coupling of two carboxylic acid groups.
Synonyms:	related_synonym:	Formula=C2H2O2R2; SMILES=C(C(=O))(O)([H]); acyloin; acyloins; secondary alpha-hydroxy-ketones; secondary alpha-hydroxyketone; secondary alpha-hydroxyketones
	xref:	Wikipedia:Acyloin

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Genes (1049)

(+)-dihydromyricetin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

mitogen activated protein kinase 1

multiple interactions

ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

platelet derived growth factor subunit B

multiple interactions

ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

platelet derived growth factor receptor beta

multiple interactions

ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

phospholipase C, gamma 1

multiple interactions

ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

sphingosine kinase 1

decreases expression
decreases activity

ampelopsin results in decreased expression of SPHK1 protein
ampelopsin results in decreased activity of SPHK1 protein

NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240

(+)-taxifolin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

taxifolin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

multiple interactions
decreases activity

taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]
taxifolin results in decreased activity of ABCC1 protein

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

acetylcholinesterase

multiple interactions

taxifolin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

adiponectin receptor 2

multiple interactions

taxifolin binds to and results in increased activity of ADIPOR2 protein

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

alpha-fetoprotein

affects binding
multiple interactions

taxifolin binds to AFP protein
alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]]

PMID:23013281 PMID:25349334 PMID:33840231

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

angiotensinogen

decreases expression

taxifolin results in decreased expression of AGT protein modified form

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

multiple interactions

AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein]; taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]]

PMID:32828744 PMID:35465754

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

apolipoprotein A1

increases expression

taxifolin results in increased expression of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein B

decreases secretion
decreases expression

taxifolin results in decreased secretion of APOB protein
taxifolin results in decreased expression of APOB protein

PMID:11108730 PMID:15380446

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

BCL2 associated X, apoptosis regulator

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of BCL2 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]]

PMID:32525071 PMID:35465754

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

beclin 1

multiple interactions

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of BECN1 protein]]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of BECN1 protein]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]; taxifolin inhibits the reaction [Colistin results in increased expression of BECN1 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of BECN1 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of BECN1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]]

PMID:33840231 PMID:33882723 PMID:35465754

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

caspase 3

decreases activity
multiple interactions

taxifolin results in decreased activity of CASP3 protein
alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP3 protein]]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP3 protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]; taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]; taxifolin inhibits the reaction [Colistin results in increased activity of CASP3 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP3 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased activity of CASP3 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]

PMID:24269735 PMID:32828744 PMID:33840231 PMID:33882723 PMID:35465754

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

decreases activity
multiple interactions

taxifolin results in decreased activity of CASP9 protein
alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP9 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP9 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP9 protein]]

PMID:24269735 PMID:33840231

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]]; taxifolin analog inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; taxifolin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CAT mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT mRNA]; taxifolin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]]
taxifolin results in decreased activity of CAT protein
taxifolin inhibits the reaction [Hydrogen Peroxide results in increased activity of CAT protein]

PMID:30372826 PMID:32525071 PMID:33741339 PMID:35187747 PMID:35465754 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin A1

decreases expression

taxifolin results in decreased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cell division cycle 25A

decreases expression

taxifolin results in decreased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

carnitine palmitoyltransferase 1A

multiple interactions

taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cytochrome c, somatic

affects localization
multiple interactions

taxifolin affects the localization of CYCS protein
[taxifolin co-treated with dapagliflozin] inhibits the reaction [Colistin results in increased expression of CYCS protein]; taxifolin inhibits the reaction [Colistin results in increased expression of CYCS protein]

PMID:24269735 PMID:33882723

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP11A1 protein]

PMID:32525071 PMID:36198370

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

taxifolin results in increased expression of CYP1A1 mRNA; taxifolin results in increased expression of CYP1A1 protein
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]

PMID:22422552 PMID:29584932

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

taxifolin results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

DCC netrin 1 receptor

increases expression

taxifolin results in increased expression of DCC mRNA

NCBI chr18:64,868,987...65,972,783
Ensembl chr18:64,873,898...65,972,740

G

epidermal growth factor

decreases expression

taxifolin results in decreased expression of EGF mRNA

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

fibroblast growth factor 18

decreases expression

taxifolin results in decreased expression of FGF18 mRNA

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

fibroblast growth factor 3

decreases expression

taxifolin results in decreased expression of FGF3 mRNA

NCBI chr 1:200,001,162...200,005,539
Ensembl chr 1:200,001,261...200,005,187

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

follicle stimulating hormone subunit beta

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

glucose-6-phosphate dehydrogenase

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]]

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest specific 6

increases expression

taxifolin results in increased expression of GAS6 mRNA

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

growth differentiation factor 15

increases expression

taxifolin results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glutamate-ammonia ligase

multiple interactions

taxifolin inhibits the reaction [Rotenone results in decreased activity of GLUL protein]

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glutamic--pyruvic transaminase

multiple interactions

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of GPT protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of GPT protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of GPT protein]]

PMID:32828744 PMID:33840231

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]; taxifolin inhibits the reaction [Colistin results in decreased expression of GSR protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of GSR protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]]

PMID:33882723 PMID:35465754

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

increases expression

taxifolin results in increased expression of GSTM1 mRNA

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

heme oxygenase 1

increases expression
multiple interactions
decreases expression

taxifolin results in increased expression of HMOX1 protein
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]]
Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of HMOX1 protein]

PMID:16799064 PMID:31152760 PMID:35465754

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxysteroid (17-beta) dehydrogenase 1

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]]

NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD17B3 protein]

PMID:32525071 PMID:36198370

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]]

PMID:35465754 PMID:36198370

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

intercellular adhesion molecule 1

multiple interactions

taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]

PMID:12044887 PMID:19103272

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

multiple interactions

taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein]
taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of IFNG protein]

PMID:12044887 PMID:19103272 PMID:31152760

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

multiple interactions

taxifolin inhibits the reaction [Rotenone results in increased expression of IKBKG mRNA]

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

interleukin 15

multiple interactions

taxifolin inhibits the reaction [Colistin results in increased expression of IL15 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of IL15 protein]]

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 18

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of IL1A protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of IL1A protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of IL1A protein]]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein]; taxifolin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]
taxifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B protein]

PMID:32828744 PMID:35187747 PMID:38574953

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]
taxifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein]

PMID:32828744 PMID:38574953

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin-like 3

multiple interactions

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSL3 protein]

PMID:32525071 PMID:36198370

NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

taxifolin results in decreased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

luteinizing hormone subunit beta

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

mitogen-activated protein kinase 8

multiple interactions

taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein]
taxifolin inhibits the reaction [Colistin results in increased activity of MAPK8 protein]

PMID:12044887 PMID:33882723

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

marker of proliferation Ki-67

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

myeloperoxidase

multiple interactions

taxifolin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; taxifolin inhibits the reaction [Rotenone results in increased activity of MPO protein]

PMID:33741339 PMID:35187747

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mechanistic target of rapamycin kinase

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]]; taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

microsomal triglyceride transfer protein

decreases activity

taxifolin results in decreased activity of MTTP protein

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions
decreases expression

taxifolin results in increased expression of NFE2L2 protein
alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of NFE2L2 protein]]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of NFE2L2 protein]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; taxifolin inhibits the reaction [Colistin results in decreased expression of NFE2L2 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of NFE2L2 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of NFE2L2 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]
taxifolin results in decreased expression of NFE2L2 protein
Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of NFE2L2 protein]

PMID:16799064 PMID:31152760 PMID:33840231 PMID:33882723 PMID:35465754

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

taxifolin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nerve growth factor

multiple interactions

taxifolin inhibits the reaction [Colistin results in decreased expression of NGF protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of NGF protein]]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

NLR family, pyrin domain containing 3

multiple interactions

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

NAD(P)H quinone dehydrogenase 1

increases activity
increases expression

taxifolin results in increased activity of NQO1 protein
taxifolin results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

O-GlcNAcase

multiple interactions

[taxifolin co-treated with dapagliflozin] inhibits the reaction [Colistin results in increased activity of OGA protein]; taxifolin inhibits the reaction [Colistin results in increased activity of OGA protein]

NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359

G

proliferating cell nuclear antigen

multiple interactions

[taxifolin co-treated with [Iron-Dextran Complex results in increased abundance of Iron]] results in increased expression of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

platelet derived growth factor subunit B

decreases expression

taxifolin results in decreased expression of PDGFB mRNA

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions

taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein]

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

paraoxonase 1

multiple interactions

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of PON1 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of PON1 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of PON1 protein]]

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

peroxisome proliferator activated receptor alpha

increases phosphorylation

taxifolin results in increased phosphorylation of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

PPARG coactivator 1 alpha

multiple interactions

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of PPARGC1A protein]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein kinase AMP-activated catalytic subunit alpha 1

decreases phosphorylation

taxifolin results in decreased phosphorylation of PRKAA1 protein

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

decreases phosphorylation

taxifolin results in decreased phosphorylation of PRKAA2 protein

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

prostaglandin-endoperoxide synthase 2

multiple interactions

taxifolin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RAS p21 protein activator 1

decreases expression

taxifolin results in decreased expression of RASA1 mRNA

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[alogliptin co-treated with taxifolin] inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of RELA protein]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of RELA protein]; taxifolin inhibits the reaction [Colistin results in increased expression of RELA protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of RELA protein]]

PMID:33840231 PMID:33882723

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

scavenger receptor class B, member 1

multiple interactions

taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 protein]

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

sirtuin 1

multiple interactions

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein]

PMID:32525071 PMID:36198370

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

superoxide dismutase 1

multiple interactions

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD2 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]

PMID:32525071 PMID:36198370

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SRY-box transcription factor 9

multiple interactions

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOX9 mRNA]

NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994

G

signal transducer and activator of transcription 1

multiple interactions

taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions

taxifolin inhibits the reaction [Colistin results in decreased expression of STAT3 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of STAT3 protein]]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 1

multiple interactions

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TGFB1 protein]]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TGFB1 protein]; taxifolin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; taxifolin inhibits the reaction [Colistin results in increased expression of TGFB1 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TGFB1 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TGFB1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]]

PMID:33840231 PMID:33882723 PMID:35465754

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tyrosine hydroxylase

multiple interactions

taxifolin inhibits the reaction [Rotenone results in decreased activity of TH protein]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

toll-like receptor 4

multiple interactions

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TLR4 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TLR4 protein]; taxifolin inhibits the reaction [Colistin results in increased expression of TLR4 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TLR4 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TLR4 protein]]

PMID:33840231 PMID:33882723

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]; taxifolin inhibits the reaction [Colistin results in increased expression of TNF protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TNF protein]]

PMID:31152760 PMID:32828744 PMID:33882723

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

Tnf receptor-associated factor 3

increases expression

taxifolin results in increased expression of TRAF3 mRNA

NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481

G

thioredoxin reductase 1

increases expression
decreases activity

taxifolin results in increased expression of TXNRD1 mRNA
taxifolin results in decreased activity of TXNRD1 protein modified form

PMID:16618767 PMID:17541156

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

uncoupling protein 1

multiple interactions

taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA]

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

G

UDP glucuronosyltransferase family 1 member A1

increases expression
multiple interactions

taxifolin results in increased expression of UGT1A1 mRNA
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA]

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

xanthine dehydrogenase

multiple interactions

taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides]
taxifolin inhibits the reaction [Rotenone results in increased activity of XDH protein]

PMID:19555678 PMID:35187747

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

XPA, DNA damage recognition and repair factor

increases expression

taxifolin results in increased expression of XPA mRNA

NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726

G

X-ray repair cross complementing 4

increases expression

taxifolin results in increased expression of XRCC4 mRNA

NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808

(R)-acetoin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member B1

increases reduction
multiple interactions

AKR1B1 protein results in increased reduction of Acetoin
[AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol; [AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1 member B10

increases reduction
multiple interactions

AKR1B10 protein results in increased reduction of Acetoin
[AKR1B10 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol; [AKR1B10 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

dicarbonyl and L-xylulose reductase

multiple interactions

1,2-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 1,4-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 9,10-phenanthrenequinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; [[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin; [DCXR protein co-treated with NAD] results in increased chemical synthesis of Acetoin; Vitamin K 3 inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]

NCBI chr10:106,006,404...106,008,293

15-acetyldeoxynivalenol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 2

increases expression

15-acetyldeoxynivalenol results in increased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

angiopoietin-like 4

increases expression

15-acetyldeoxynivalenol results in increased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

androgen receptor

decreases activity
multiple interactions

15-acetyldeoxynivalenol results in decreased activity of AR protein
[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of AR protein; [15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol] results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

activity-regulated cytoskeleton-associated protein

increases expression

15-acetyldeoxynivalenol results in increased expression of ARC mRNA

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

amphiregulin

increases expression

15-acetyldeoxynivalenol results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

AT-rich interaction domain 5A

increases expression

15-acetyldeoxynivalenol results in increased expression of ARID5A mRNA

NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597

G

ARF like GTPase 5B

increases expression

15-acetyldeoxynivalenol results in increased expression of ARL5B mRNA

NCBI chr17:77,955,864...77,979,895
Ensembl chr17:77,955,818...77,979,854

G

arrestin domain containing 4

increases expression

15-acetyldeoxynivalenol results in increased expression of ARRDC4 mRNA

NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290

G

activating transcription factor 3

increases expression
multiple interactions

15-acetyldeoxynivalenol results in increased expression of ATF3 mRNA
[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [15-acetyldeoxynivalenol results in increased expression of ATF3 mRNA]

PMID:19101521 PMID:22003189 PMID:23792671

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 6

increases expression

15-acetyldeoxynivalenol results in increased expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

atos homolog B

increases expression

15-acetyldeoxynivalenol results in increased expression of ATOSB mRNA

NCBI chr 5:57,260,839...57,274,524
Ensembl chr 5:57,260,841...57,268,892

G

bradykinin receptor B1

increases expression

15-acetyldeoxynivalenol results in increased expression of BDKRB1 mRNA

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

increases expression

15-acetyldeoxynivalenol results in increased expression of BDKRB2 mRNA

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

basic helix-loop-helix family, member e40

increases expression

15-acetyldeoxynivalenol results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

BTG anti-proliferation factor 2

increases expression

15-acetyldeoxynivalenol results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

similar to human chromosome 11 open reading frame 96

increases expression

15-acetyldeoxynivalenol results in increased expression of C11ORF96 mRNA

NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523

G

coiled-coil domain containing 116

increases expression

15-acetyldeoxynivalenol results in increased expression of CCDC116 mRNA

NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607

G

cholecystokinin

increases expression

15-acetyldeoxynivalenol results in increased expression of CCK protein

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

C-C motif chemokine ligand 2

increases expression

15-acetyldeoxynivalenol results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

increases expression

15-acetyldeoxynivalenol results in increased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

increases expression

15-acetyldeoxynivalenol results in increased expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 7

increases expression

15-acetyldeoxynivalenol results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine receptor 7

increases expression

15-acetyldeoxynivalenol results in increased expression of CCR7 mRNA

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

cAMP responsive element modulator

increases expression

15-acetyldeoxynivalenol results in increased expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

C-X-C motif chemokine ligand 2

increases expression

15-acetyldeoxynivalenol results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine receptor 4

increases expression

15-acetyldeoxynivalenol results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

DNA-damage inducible transcript 3

increases expression

15-acetyldeoxynivalenol results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DIX domain containing 1

increases expression

15-acetyldeoxynivalenol results in increased expression of DIXDC1 mRNA

NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090

G

distal-less homeobox 1

increases expression

15-acetyldeoxynivalenol results in increased expression of DLX1 mRNA

NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780

G

distal-less homeobox 2

increases expression

15-acetyldeoxynivalenol results in increased expression of DLX2 mRNA

NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597

G

doublesex and mab-3 related transcription factor 2

increases expression

15-acetyldeoxynivalenol results in increased expression of DMRT2 mRNA

NCBI chr 1:223,317,543...223,324,131
Ensembl chr 1:223,317,642...223,324,131

G

DnaJ heat shock protein family (Hsp40) member B5

increases expression

15-acetyldeoxynivalenol results in increased expression of DNAJB5 mRNA

NCBI chr 5:57,176,840...57,186,067
Ensembl chr 5:57,176,845...57,185,490

G

dual specificity phosphatase 10

increases expression

15-acetyldeoxynivalenol results in increased expression of DUSP10 mRNA

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

G

dual specificity phosphatase 8

increases expression

15-acetyldeoxynivalenol results in increased expression of DUSP8 mRNA

NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921

G

early growth response 3

increases expression

15-acetyldeoxynivalenol results in increased expression of EGR3 mRNA

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

eukaryotic translation initiation factor 2A

increases phosphorylation

15-acetyldeoxynivalenol results in increased phosphorylation of EIF2A protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

empty spiracles homeobox 2

increases expression

15-acetyldeoxynivalenol results in increased expression of EMX2 mRNA

NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594

G

Eph receptor B3

increases expression

15-acetyldeoxynivalenol results in increased expression of EPHB3 mRNA

NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370

G

epiregulin

increases expression

15-acetyldeoxynivalenol results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

endoplasmic reticulum to nucleus signaling 1

decreases expression

15-acetyldeoxynivalenol results in decreased expression of ERN1 mRNA

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

family with sequence similarity 43, member A

increases expression

15-acetyldeoxynivalenol results in increased expression of FAM43A mRNA

NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401

G

fructose-bisphosphatase 2

increases expression

15-acetyldeoxynivalenol results in increased expression of FBP2 mRNA

NCBI chr17:2,236,088...2,253,702
Ensembl chr17:2,236,336...2,253,698

G

fibroblast growth factor 9

increases expression

15-acetyldeoxynivalenol results in increased expression of FGF9 mRNA

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

four-jointed box kinase 1

increases expression

15-acetyldeoxynivalenol results in increased expression of FJX1 mRNA

NCBI chr 3:88,774,220...88,776,321
Ensembl chr 3:88,774,220...88,776,321

G

GTP binding protein overexpressed in skeletal muscle

increases expression

15-acetyldeoxynivalenol results in increased expression of GEM mRNA

NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222

G

Gfo/Idh/MocA-like oxidoreductase domain containing 1

increases expression

15-acetyldeoxynivalenol results in increased expression of GFOD1 mRNA

NCBI chr17:21,400,142...21,504,972
Ensembl chr17:21,399,479...21,499,938

G

GTF2I repeat domain containing 2

increases expression

15-acetyldeoxynivalenol results in increased expression of GTF2IRD2 mRNA

NCBI chr12:22,497,767...22,536,455
Ensembl chr12:22,498,091...22,536,263

G

hyaluronan synthase 2

increases expression

15-acetyldeoxynivalenol results in increased expression of HAS2 mRNA

NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933

G

homeobox B2

increases expression

15-acetyldeoxynivalenol results in increased expression of HOXB2 mRNA

NCBI chr10:81,317,828...81,320,220
Ensembl chr10:81,318,026...81,320,192

G

heparanase 2 (inactive)

increases expression

15-acetyldeoxynivalenol results in increased expression of HPSE2 mRNA

NCBI chr 1:241,582,904...242,284,348
Ensembl chr 1:241,583,187...242,246,118

G

heat shock protein family A (Hsp70) member 5

decreases expression

15-acetyldeoxynivalenol results in decreased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

interleukin 10 receptor subunit alpha

increases expression

15-acetyldeoxynivalenol results in increased expression of IL10RA mRNA

NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061

G

interleukin 1 beta

increases expression

15-acetyldeoxynivalenol results in increased expression of IL1B mRNA

PMID:23792671 PMID:24793808

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

affects secretion
increases expression

15-acetyldeoxynivalenol affects the secretion of IL2 protein
15-acetyldeoxynivalenol results in increased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

affects secretion

15-acetyldeoxynivalenol affects the secretion of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

affects secretion

15-acetyldeoxynivalenol affects the secretion of IL5 protein

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

increases expression

15-acetyldeoxynivalenol results in increased expression of IL6 mRNA

PMID:8560498 PMID:24793808

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

IQ motif containing N

increases expression

15-acetyldeoxynivalenol results in increased expression of IQCN mRNA

NCBI chr16:18,716,519...18,733,971
Ensembl chr16:18,716,519...18,726,261

G

immunity-related GTPase M

increases expression

15-acetyldeoxynivalenol results in increased expression of IRGM mRNA

NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578

G

potassium inwardly-rectifying channel, subfamily J, member 2

increases expression

15-acetyldeoxynivalenol results in increased expression of KCNJ2 mRNA

NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445

G

KLF transcription factor 10

increases expression

15-acetyldeoxynivalenol results in increased expression of KLF10 mRNA

NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994

G

mannosidase, alpha, class 1B, member 1

increases expression

15-acetyldeoxynivalenol results in increased expression of MAN1B1 mRNA

NCBI chr 3:8,143,877...8,165,007
Ensembl chr 3:8,143,381...8,165,006

G

MFSD2 lysolipid transporter A, lysophospholipid

increases expression

15-acetyldeoxynivalenol results in increased expression of MFSD2A mRNA

NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690

G

muscle RAS oncogene homolog

increases expression

15-acetyldeoxynivalenol results in increased expression of MRAS mRNA

NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408

G

maestro heat-like repeat family member 3

increases expression

15-acetyldeoxynivalenol results in increased expression of MROH3P mRNA

NCBI chr13:47,630,004...47,665,461
Ensembl chr13:47,630,003...47,665,394

G

max dimerization protein 1

increases expression

15-acetyldeoxynivalenol results in increased expression of MXD1 mRNA

NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751

G

neuralized E3 ubiquitin protein ligase 3

increases expression

15-acetyldeoxynivalenol results in increased expression of NEURL3 mRNA

NCBI chr 9:38,494,486...38,503,352
Ensembl chr 9:38,494,489...38,502,649

G

nucleotide-binding oligomerization domain containing 2

multiple interactions

[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [15-acetyldeoxynivalenol results in increased expression of ATF3 mRNA]

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

nuclear receptor subfamily 4, group A, member 3

increases expression

15-acetyldeoxynivalenol results in increased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

NACHT and WD repeat domain containing 2

increases expression

15-acetyldeoxynivalenol results in increased expression of NWD2 mRNA

NCBI chr14:44,480,049...44,671,417
Ensembl chr14:44,482,287...44,670,299

G

protocadherin 9

increases expression

15-acetyldeoxynivalenol results in increased expression of PCDH9 mRNA

NCBI chr15:69,340,108...70,237,531
Ensembl chr15:69,340,645...70,237,538

G

period circadian regulator 1

increases expression

15-acetyldeoxynivalenol results in increased expression of PER1 mRNA

NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431

G

peroxisome proliferator-activated receptor gamma

decreases activity

15-acetyldeoxynivalenol results in decreased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

increases expression

15-acetyldeoxynivalenol results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

regulator of calcineurin 1

increases expression

15-acetyldeoxynivalenol results in increased expression of RCAN1 mRNA

NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045

G

RRAD and GEM like GTPase 2

increases expression

15-acetyldeoxynivalenol results in increased expression of REM2 mRNA

NCBI chr15:27,933,950...27,938,429
Ensembl chr15:27,933,950...27,938,429

G

regulator of G-protein signaling 16

increases expression

15-acetyldeoxynivalenol results in increased expression of RGS16 mRNA

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

G

ras homolog family member H

increases expression

15-acetyldeoxynivalenol results in increased expression of RHOH mRNA

NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369

G

Rho family GTPase 1

increases expression

15-acetyldeoxynivalenol results in increased expression of RND1 mRNA

NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399

G

SIX homeobox 1

increases expression

15-acetyldeoxynivalenol results in increased expression of SIX1 mRNA

NCBI chr 6:91,746,739...91,751,975
Ensembl chr 6:91,746,739...91,751,975

G

solute carrier family 34 member 1

increases expression

15-acetyldeoxynivalenol results in increased expression of SLC34A1 mRNA

NCBI chr17:9,218,876...9,233,852
Ensembl chr17:9,218,876...9,233,852

G

stathmin 4

increases expression

15-acetyldeoxynivalenol results in increased expression of STMN4 mRNA

NCBI chr15:40,541,305...40,559,253
Ensembl chr15:40,541,357...40,559,253

G

storkhead box 2

increases expression

15-acetyldeoxynivalenol results in increased expression of STOX2 mRNA

NCBI chr16:44,848,179...45,087,238
Ensembl chr16:44,848,078...45,085,105

G

transcription factor AP-2 alpha

increases expression

15-acetyldeoxynivalenol results in increased expression of TFAP2A mRNA

NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507

G

thyroid hormone receptor beta

multiple interactions

[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

transmembrane and coiled-coil domain family 2

increases expression

15-acetyldeoxynivalenol results in increased expression of TMCC2 mRNA

NCBI chr13:43,794,029...43,831,716
Ensembl chr13:43,794,029...43,831,716

G

transmembrane protein 88

increases expression

15-acetyldeoxynivalenol results in increased expression of TMEM88 mRNA

NCBI chr10:54,118,752...54,120,447
Ensembl chr10:54,118,752...54,120,447

G

tumor necrosis factor

increases expression

15-acetyldeoxynivalenol results in increased expression of TNF mRNA

PMID:23792671 PMID:24793808

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

uncoupling protein 1

increases expression

15-acetyldeoxynivalenol results in increased expression of UCP1 mRNA

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

G

zinc finger and BTB domain containing 21

increases expression

15-acetyldeoxynivalenol results in increased expression of ZBTB21 mRNA

NCBI chr11:37,312,337...37,327,040
Ensembl chr11:37,312,378...37,326,996

G

zinc finger CCCH type containing 12D

increases expression

15-acetyldeoxynivalenol results in increased expression of ZC3H12D mRNA

NCBI chr 1:2,313,110...2,348,820
Ensembl chr 1:2,314,324...2,348,819

G

zinc finger protein 2

increases expression

15-acetyldeoxynivalenol results in increased expression of ZFP2 mRNA

NCBI chr10:35,209,187...35,228,849
Ensembl chr10:35,207,260...35,228,853

G

zinc finger protein 77

increases expression

15-acetyldeoxynivalenol results in increased expression of ZNF77 mRNA

NCBI chr 7:7,269,879...7,316,286
Ensembl chr 7:7,269,927...7,286,051

3-acetyldeoxynivalenol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

decreases activity
multiple interactions

3-acetyldeoxynivalenol results in decreased activity of AR protein
[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of AR protein; [15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol] results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

activating transcription factor 4

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of ATF4 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ATF4 mRNA]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of ATF6 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ATF6 mRNA]

PMID:20682335 PMID:35413383

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

cholecystokinin

increases expression

3-acetyldeoxynivalenol results in increased expression of CCK protein

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

C-C motif chemokine ligand 2

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of CCL2 mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CCL2 protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CCL2 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CCL2 mRNA]

PMID:24793808 PMID:35413383

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 7

increases expression

3-acetyldeoxynivalenol results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

colony stimulating factor 1

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of CSF1 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CSF1 mRNA]

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

colony stimulating factor 2

multiple interactions

3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CSF2 protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of CSF2 protein]

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

multiple interactions
increases expression

4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CSF3 mRNA]

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

C-X-C motif chemokine ligand 2

increases expression

3-acetyldeoxynivalenol results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of DDIT3 mRNA]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2A

increases phosphorylation

3-acetyldeoxynivalenol results in increased phosphorylation of EIF2A protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression

3-acetyldeoxynivalenol results in increased expression of EIF2AK3 mRNA

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of EIF2S1 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of EIF2S1 mRNA]

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

endoplasmic reticulum to nucleus signaling 1

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of ERN1 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ERN1 mRNA]

PMID:20682335 PMID:35413383

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

heat shock protein family A (Hsp70) member 5

decreases expression
increases expression
multiple interactions

3-acetyldeoxynivalenol results in decreased expression of HSPA5 mRNA
3-acetyldeoxynivalenol results in increased expression of HSPA5 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of HSPA5 mRNA]

PMID:20682335 PMID:35413383

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

interferon beta 1

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of IFNB1 mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IFNB1 protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IFNB1 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IFNB1 mRNA]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

multiple interactions
increases expression

4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IFNG mRNA]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions
increases expression

3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL10 protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL10 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL10 mRNA]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 17A

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of IL17A mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL17A protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL17A protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL17A mRNA]

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 1 alpha

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of IL1A mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1A protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1A protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL1A mRNA]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of IL1B mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1B protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL1B mRNA]

PMID:24793808 PMID:35413383

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

affects secretion
increases expression

3-acetyldeoxynivalenol affects the secretion of IL2 protein
3-acetyldeoxynivalenol results in increased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

affects secretion

3-acetyldeoxynivalenol affects the secretion of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

affects secretion

3-acetyldeoxynivalenol affects the secretion of IL5 protein

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of IL6 mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL6 protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of IL6 protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of IL6 mRNA]

PMID:24793808 PMID:35413383

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen-activated protein kinase 8

multiple interactions
increases expression

4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of MAPK8 mRNA]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

myeloperoxidase

multiple interactions
increases secretion

4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased secretion of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

peroxisome proliferator-activated receptor gamma

decreases activity

3-acetyldeoxynivalenol results in decreased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

increases expression

3-acetyldeoxynivalenol results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

thyroid hormone receptor beta

decreases activity
multiple interactions

3-acetyldeoxynivalenol results in decreased activity of THRB protein
[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

tumor necrosis factor

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of TNF mRNA
3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of TNF protein; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of and results in increased secretion of TNF protein]; 4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of TNF mRNA]

PMID:24793808 PMID:35413383

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

X-box binding protein 1

increases expression
multiple interactions

3-acetyldeoxynivalenol results in increased expression of XBP1 mRNA
4-phenylbutyric acid inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of XBP1 mRNA]

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

5Z-7-oxozeaenol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

baculoviral IAP repeat-containing 3

decreases expression

(5Z)-7-oxozeaenol decreases expression of BIRC3 protein in esophageal adenocarcinoma cells

RGD

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

mitogen activated protein kinase kinase kinase 7

decreases phosphorylation

5Z-7-oxozeaenol decreases phosphorylation of Map3k7 protein in hypertrophic heart

RGD

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

acetoin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member B1

increases reduction
multiple interactions

AKR1B1 protein results in increased reduction of Acetoin
[AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol; [AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1 member B10

increases reduction
multiple interactions

AKR1B10 protein results in increased reduction of Acetoin
[AKR1B10 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2,3-butylene glycol; [AKR1B10 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

dicarbonyl and L-xylulose reductase

multiple interactions

1,2-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 1,4-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; 9,10-phenanthrenequinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]; [[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin; [DCXR protein co-treated with NAD] results in increased chemical synthesis of Acetoin; Vitamin K 3 inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]

NCBI chr10:106,006,404...106,008,293

astilbin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1, member C1

multiple interactions

[astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

AKT serine/threonine kinase 1

multiple interactions

astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2 associated X, apoptosis regulator

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions

astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

interleukin 1 beta

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

NFE2 like bZIP transcription factor 2

multiple interactions

astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein]
astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

poly (ADP-ribose) polymerase 1

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

prostaglandin-endoperoxide synthase 2

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

tumor necrosis factor

multiple interactions

astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA]
astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

bruceine D

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catenin beta 1

decreases expression
multiple interactions

bruceine D results in decreased expression of CTNNB1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of CTNNB1 protein]]; bruceine D affects the reaction [Oxygen deficiency affects the expression of CTNNB1 protein]; bruceine D inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

catenin, beta-interacting protein 1

decreases expression
multiple interactions
affects binding

bruceine D results in decreased expression of CTNNBIP1 protein
bruceine D inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of HK2 protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of LDHA protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of PKM protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC16A3 protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A1 protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A3 protein]]; CTNNBIP1 protein affects the reaction [bruceine D inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]
bruceine D binds to CTNNBIP1 protein

NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939

G

cytochrome c, somatic

multiple interactions
decreases expression

bruceine D affects the reaction [Oxygen deficiency affects the expression of CYCS protein]
bruceine D results in decreased expression of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases expression

bruceine D inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; bruceine D inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; CTNNBIP1 protein affects the reaction [bruceine D inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Cycloheximide inhibits the reaction [bruceine D inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]
bruceine D results in decreased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hexokinase 2

multiple interactions

bruceine D affects the reaction [Oxygen deficiency affects the expression of HK2 protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of HK2 protein]]

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

lactate dehydrogenase A

decreases expression
multiple interactions

bruceine D results in decreased expression of LDHA protein
bruceine D affects the reaction [Oxygen deficiency affects the expression of LDHA protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of LDHA protein]]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

pyruvate kinase M1/2

multiple interactions

bruceine D affects the reaction [Oxygen deficiency affects the expression of PKM protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of PKM protein]]

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

solute carrier family 16 member 3

multiple interactions

bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC16A3 protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC16A3 protein]]

NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562

G

solute carrier family 2 member 1

decreases expression
multiple interactions

bruceine D results in decreased expression of SLC2A1 protein
bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A1 protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A1 protein]]

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 3

decreases expression
multiple interactions

bruceine D results in decreased expression of SLC2A3 protein
bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A3 protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A3 protein]]

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

cabazitaxel

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT1 substrate 1

decreases expression

cabazitaxel results in decreased expression of AKT1S1 protein

NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677

G

BCL2 associated X, apoptosis regulator

increases expression

cabazitaxel results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

cabazitaxel results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases expression

cabazitaxel results in increased expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

forkhead box O3

affects expression

cabazitaxel affects the expression of FOXO3 protein

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

RELA proto-oncogene, NF-kB subunit

increases expression
multiple interactions

cabazitaxel results in increased expression of RELA mRNA
cabazitaxel affects the expression of and affects the localization of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier organic anion transporter family member 1B2

increases import

SLCO1B3 protein results in increased import of cabazitaxel

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

toll-like receptor 4

decreases expression

cabazitaxel results in decreased expression of TLR4 mRNA; cabazitaxel results in decreased expression of TLR4 protein

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

chaetoglobosin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

chaetoglobosins results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

gap junction protein, alpha 1

multiple interactions

chaetoglobosins inhibits the reaction [Dieldrin results in decreased phosphorylation of GJA1 protein]; chaetoglobosins inhibits the reaction [Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glycogen synthase kinase 3 beta

increases phosphorylation
multiple interactions

chaetoglobosins results in increased phosphorylation of GSK3B protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

interferon beta 1

multiple interactions

chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interleukin 1 beta

multiple interactions

chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interferon regulatory factor 7

multiple interactions

chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IRF7 mRNA]

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

chaetoglobosins results in increased phosphorylation of MAPK1 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]

PMID:18040759 PMID:33285210

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

chaetoglobosins results in increased phosphorylation of MAPK3 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]

PMID:18040759 PMID:33285210

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MYD88, innate immune signal transduction adaptor

multiple interactions

chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

nitric oxide synthase 2

multiple interactions

chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

prostaglandin-endoperoxide synthase 2

multiple interactions

chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases phosphorylation

chaetoglobosins results in decreased phosphorylation of RAF1 protein

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

toll-like receptor 4

multiple interactions

chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; chaetoglobosins results in increased expression of and results in increased secretion of TNF protein

PMID:28535995 PMID:33285210

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Cohumulone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member B10

decreases activity

cohumulone results in decreased activity of AKR1B10 protein

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

cucurbitacin B

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adiponectin, C1Q and collagen domain containing

decreases expression

cucurbitacin B results in decreased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

BCL2-associated agonist of cell death

increases expression
multiple interactions

cucurbitacin B results in increased expression of BAD mRNA
[cucurbitacin B co-treated with Gefitinib] results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2-antagonist/killer 1

multiple interactions
increases expression

[cucurbitacin B co-treated with Gefitinib] results in increased expression of BAK1 mRNA; [cucurbitacin B co-treated with Gefitinib] results in increased expression of BAK1 protein
cucurbitacin B results in increased expression of BAK1 mRNA; cucurbitacin B results in increased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of BAX mRNA]
cucurbitacin B results in increased expression of BAX mRNA; cucurbitacin B results in increased expression of BAX protein
[cucurbitacin B co-treated with Gefitinib] results in increased expression of BAX mRNA; [cucurbitacin B co-treated with Gefitinib] results in increased expression of BAX protein

PMID:26183715 PMID:29250925

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2 mRNA]
[cucurbitacin B co-treated with Gefitinib] results in decreased expression of BCL2 mRNA; [cucurbitacin B co-treated with Gefitinib] results in decreased expression of BCL2 protein
cucurbitacin B results in decreased expression of BCL2 mRNA; cucurbitacin B results in decreased expression of BCL2 protein

PMID:26183715 PMID:29250925

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

[cucurbitacin B co-treated with Gefitinib] results in decreased expression of BCL2L1 mRNA
cucurbitacin B results in decreased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

increases expression
multiple interactions

cucurbitacin B results in increased expression of BCL2L11 mRNA
[cucurbitacin B co-treated with Gefitinib] results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

caspase 3

increases cleavage
multiple interactions

cucurbitacin B results in increased cleavage of CASP3 protein
[cucurbitacin B co-treated with Gefitinib] results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

cucurbitacin B inhibits the reaction [Gefitinib results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

decreases expression
multiple interactions

cucurbitacin B results in decreased expression of CCND1
[cucurbitacin B co-treated with Gefitinib] results in decreased expression of CCND1 mRNA; [cucurbitacin B co-treated with Gefitinib] results in decreased expression of CCND1 protein
cucurbitacin B results in decreased expression of CCND1 mRNA; cucurbitacin B results in decreased expression of CCND1 protein

PMID:24316209 PMID:26183715

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

CD36 molecule

decreases expression

cucurbitacin B results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

[cucurbitacin B co-treated with Gefitinib] results in increased expression of CDKN1B protein
cucurbitacin B results in increased expression of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CCAAT/enhancer binding protein alpha

decreases expression
multiple interactions

cucurbitacin B results in decreased expression of CEBPA mRNA
STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of CEBPA mRNA]

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein delta

decreases expression

cucurbitacin B results in decreased expression of CEBPD

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

collagen type I alpha 1 chain

multiple interactions

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

epidermal growth factor receptor

multiple interactions

[cucurbitacin B co-treated with Gefitinib] results in decreased phosphorylation of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

fatty acid binding protein 4

decreases expression

cucurbitacin B results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

glutamic-oxaloacetic transaminase 1

multiple interactions

cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GOT1 protein]
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein]
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of HIF1A mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of HIF1A protein]
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

interleukin 1 beta

multiple interactions

cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL1B protein]; cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL1B mRNA]

PMID:29250925 PMID:38104874

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL6 mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL6 protein]
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

KLF transcription factor 5

increases expression

cucurbitacin B results in increased expression of KLF5

NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445

G

matrix metallopeptidase 2

multiple interactions

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP2 mRNA]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

peroxisome proliferator-activated receptor gamma

multiple interactions
decreases expression

STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of PPARG mRNA]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation
affects response to substance

[WP1066 results in decreased activity of STAT3 protein] which results in decreased susceptibility to cucurbitacin B; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 protein]; cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]; cucurbitacin B results in decreased phosphorylation of and results in decreased activity of STAT3 protein; STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of CEBPA mRNA]; STAT3 protein affects the reaction [cucurbitacin B results in decreased expression of PPARG mRNA]
cucurbitacin B results in decreased phosphorylation of STAT3 protein
[cucurbitacin B co-treated with Gefitinib] results in decreased phosphorylation of STAT3 protein; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of and results in increased phosphorylation of STAT3 mRNA]
STAT3 protein affects the susceptibility to cucurbitacin B

PMID:24316209 PMID:26183715 PMID:29250925 PMID:38104874

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 1

multiple interactions

cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF protein]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of TNF protein]; cucurbitacin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of TNF mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of TNF protein]

PMID:29250925 PMID:38104874

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

deoxynivalenol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases response to substance
multiple interactions

ABCB1 protein results in decreased susceptibility to deoxynivalenol
deoxynivalenol inhibits the reaction [valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 3

decreases expression

deoxynivalenol results in decreased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily F member 1

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of ABCF1 protein

PMID:23352502 PMID:23811945

NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433

G

abl-interactor 1

increases phosphorylation

deoxynivalenol results in increased phosphorylation of ABI1 protein

NCBI chr17:85,098,837...85,179,829
Ensembl chr17:85,098,550...85,179,792

G

abraxas 2, BRISC complex subunit

increases expression

deoxynivalenol results in increased expression of ABRAXAS2 mRNA

NCBI chr 1:187,647,078...187,672,660
Ensembl chr 1:187,647,067...187,672,655

G

aggrecan

decreases expression

deoxynivalenol results in decreased expression of ACAN mRNA

NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627

G

apoptotic chromatin condensation inducer 1

affects phosphorylation

deoxynivalenol affects the phosphorylation of ACIN1 protein

NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001

G

acyl-CoA synthetase long-chain family member 4

decreases expression

deoxynivalenol results in decreased expression of ACSL4 protein

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

actin, alpha 1, skeletal muscle

affects phosphorylation

deoxynivalenol affects the phosphorylation of ACTA1 protein

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin, beta-like 2

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of ACTBL2 protein

NCBI chr 2:42,858,020...42,860,767
Ensembl chr 2:42,858,020...42,860,767

G

AFG2 AAA ATPase homolog B

increases expression

deoxynivalenol results in increased expression of AFG2B mRNA

NCBI chr 3:109,694,739...109,708,356
Ensembl chr 3:109,694,757...109,707,757

G

ArfGAP with FG repeats 1

affects phosphorylation
increases expression

deoxynivalenol affects the phosphorylation of AGFG1 protein
deoxynivalenol results in increased expression of AGFG1 mRNA

PMID:23811945 PMID:31863870

NCBI chr 9:84,124,845...84,182,615
Ensembl chr 9:84,125,120...84,178,128

G

AHNAK nucleoprotein

affects phosphorylation

deoxynivalenol affects the phosphorylation of AHNAK protein

PMID:23352502 PMID:23811945

NCBI chr 1:205,882,225...205,970,934
Ensembl chr 1:205,882,273...205,970,926

G

aryl hydrocarbon receptor

multiple interactions
increases expression

2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of AHR mRNA]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of AHR protein]]; 6-formylindolo(3,2-b)carbazole promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of AHR mRNA]]; 6-formylindolo(3,2-b)carbazole promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of AHR protein]]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of AHR mRNA]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of AHR protein]
deoxynivalenol results in increased expression of AHR mRNA; deoxynivalenol results in increased expression of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

ajuba LIM protein

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of AJUBA protein

NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021

G

adenylate kinase 7

decreases expression

deoxynivalenol results in decreased expression of AK7 mRNA

NCBI chr 6:124,611,789...124,679,978
Ensembl chr 6:124,611,902...124,679,961

G

A-kinase anchoring protein 8 like

increases expression

deoxynivalenol results in increased expression of AKAP8L mRNA

NCBI chr 7:11,332,671...11,362,287
Ensembl chr 7:11,332,672...11,362,275

G

aldo-keto reductase family 1, member B7

multiple interactions

[Selenomethionine co-treated with deoxynivalenol] results in increased expression of AKR1B7 mRNA

NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation
decreases phosphorylation

AKT1 protein affects the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; AKT1 protein affects the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]; deoxynivalenol results in increased phosphorylation of and results in increased activity of AKT1 protein; Docosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased phosphorylation of AKT1 protein]; lauric acid inhibits the reaction [deoxynivalenol results in decreased phosphorylation of AKT1 protein]
[Zearalenone co-treated with deoxynivalenol] results in decreased phosphorylation of AKT1 protein

PMID:15976193 PMID:16424113 PMID:24937323 PMID:34506767 PMID:35090964 More...

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

decreases expression
multiple interactions
increases expression

deoxynivalenol results in decreased expression of ALB protein
[deoxynivalenol co-treated with Zearalenone] affects the expression of ALB mRNA; [deoxynivalenol co-treated with Zearalenone] results in decreased expression of ALB protein; [deoxynivalenol co-treated with Zearalenone] results in increased expression of ALB mRNA
deoxynivalenol results in decreased expression of ALB mRNA; deoxynivalenol results in decreased expression of ALB protein
deoxynivalenol results in increased expression of ALB mRNA

PMID:25445755 PMID:28865950 PMID:28935499

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 3 family, member B1

decreases expression

deoxynivalenol results in decreased expression of ALDH3B1 mRNA

NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921

G

aldolase, fructose-bisphosphate B

increases expression
multiple interactions

deoxynivalenol results in increased expression of ALDOB mRNA
[deoxynivalenol co-treated with Zearalenone] affects the expression of ALDOB mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of ALDOB mRNA

PMID:28865950 PMID:28935499

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

alkB homolog 1, histone H2A dioxygenase

increases expression

deoxynivalenol results in increased expression of ALKBH1 mRNA

NCBI chr 6:107,068,301...107,088,784
Ensembl chr 6:107,068,475...107,088,759

G

alkaline phosphatase, intestinal

multiple interactions

deoxynivalenol results in decreased expression of and results in decreased activity of ALPI protein

NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877

G

alpha-kinase 2

decreases expression

deoxynivalenol results in decreased expression of ALPK2 mRNA

NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258

G

adhesion molecule with Ig like domain 2

decreases expression

deoxynivalenol results in decreased expression of AMIGO2 mRNA

NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695

G

angiopoietin like 7

decreases expression

deoxynivalenol results in decreased expression of ANGPTL7 mRNA

NCBI chr 5:158,932,096...158,937,281
Ensembl chr 5:158,932,794...158,937,324

G

ankyrin repeat domain 13C

increases expression

deoxynivalenol results in increased expression of ANKRD13C mRNA

NCBI chr 2:247,023,040...247,070,433
Ensembl chr 2:247,022,286...247,070,433
Ensembl chr 4:247,022,286...247,070,433

G

ankyrin repeat domain 37

decreases expression

deoxynivalenol results in decreased expression of ANKRD37 mRNA

NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963

G

anillin, actin binding protein

increases expression

deoxynivalenol results in increased expression of ANLN mRNA

NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538

G

alanyl aminopeptidase, membrane

decreases expression

deoxynivalenol results in decreased expression of ANPEP mRNA

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

amine oxidase, copper containing 1

increases activity
multiple interactions

deoxynivalenol results in increased activity of AOC1 protein
Curcumin inhibits the reaction [deoxynivalenol results in increased activity of AOC1 protein]

NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840

G

androgen receptor

decreases activity
multiple interactions

deoxynivalenol results in decreased activity of AR protein
[15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol co-treated with zearalenol co-treated with Zearalenone] results in decreased activity of AR protein; [15-acetyldeoxynivalenol co-treated with 3-acetyldeoxynivalenol co-treated with deoxynivalenol] results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arginine and glutamate rich 1

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of ARGLU1 protein

NCBI chr16:80,753,300...80,777,350
Ensembl chr16:80,753,315...80,777,349

G

Rho GTPase activating protein 45

affects phosphorylation

deoxynivalenol affects the phosphorylation of ARHGAP45 protein

NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268

G

arkadia (RNF111) N-terminal like PKA signaling regulator 2N

increases expression

deoxynivalenol results in increased expression of ARK2N mRNA

NCBI chr18:71,155,956...71,243,655
Ensembl chr18:71,157,700...71,243,482

G

armadillo repeat containing 10

affects phosphorylation
increases phosphorylation

deoxynivalenol affects the phosphorylation of ARMC10 protein
deoxynivalenol results in increased phosphorylation of ARMC10 protein

PMID:23352502 PMID:23811945

NCBI chr 4:13,399,004...13,414,594
Ensembl chr 4:13,395,207...13,414,548

G

activating signal cointegrator 1 complex subunit 3

increases expression

deoxynivalenol results in increased expression of ASCC3 mRNA

NCBI chr20:53,510,137...53,795,446
Ensembl chr20:53,510,184...53,790,165

G

achaete-scute family bHLH transcription factor 2

increases expression

deoxynivalenol results in increased expression of ASCL2 mRNA

NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406

G

achaete-scute family bHLH transcription factor 4

increases expression

deoxynivalenol results in increased expression of ASCL4 mRNA

NCBI chr 7:17,940,972...17,943,215
Ensembl chr 7:17,941,709...17,942,146

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

deoxynivalenol results in decreased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 1

multiple interactions
increases phosphorylation
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF1 protein]; Docosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF1 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF1 protein]
deoxynivalenol results in increased expression of ATF1 mRNA

PMID:16424113 PMID:22846391

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

activating transcription factor 2

increases expression
multiple interactions
increases phosphorylation
affects localization

deoxynivalenol results in increased expression of ATF2 mRNA
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATF2 protein]
deoxynivalenol affects the localization of ATF2 protein

PMID:12604842 PMID:15772366 PMID:22846391

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

activating transcription factor 3

multiple interactions
decreases expression
increases expression
increases response to substance
decreases degradation

[[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] which co-treated with deoxynivalenol] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of ATF3 mRNA; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of ATF3 mRNA]; ATF3 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein]; ATF3 protein affects the reaction [deoxynivalenol results in increased expression of EGR1 protein]; EP300 protein affects the reaction [deoxynivalenol results in increased expression of ATF3 protein alternative form]; KAT2A protein affects the reaction [deoxynivalenol results in increased expression of ATF3 protein alternative form]; KAT2B protein affects the reaction [deoxynivalenol results in increased expression of ATF3 protein alternative form]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased degradation of ATF3 protein]
deoxynivalenol results in decreased expression of ATF3 mRNA
deoxynivalenol results in increased expression of ATF3 mRNA; deoxynivalenol results in increased expression of ATF3 protein; deoxynivalenol results in increased expression of ATF3 protein alternative form
ATF3 protein results in increased susceptibility to deoxynivalenol
deoxynivalenol results in decreased degradation of ATF3 mRNA; deoxynivalenol results in decreased degradation of ATF3 protein

PMID:19101521 PMID:19360757 PMID:21074547 PMID:22003189 PMID:22846391 More...

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 6

multiple interactions
increases expression

ATF6 protein affects the reaction [deoxynivalenol results in increased expression of IL6 mRNA]
deoxynivalenol results in increased expression of ATF6 protein
deoxynivalenol results in increased expression of ATF6 mRNA

PMID:19336499 PMID:20682335 PMID:22846391

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

autophagy related 14

increases expression

deoxynivalenol results in increased expression of ATG14 mRNA

NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113

G

autophagy related 4B, cysteine peptidase

increases expression

deoxynivalenol results in increased expression of ATG4B mRNA

NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103

G

autophagy related 5

increases expression
multiple interactions

deoxynivalenol results in increased expression of ATG5 mRNA; deoxynivalenol results in increased expression of ATG5 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 mRNA]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 protein]]; 6-formylindolo(3,2-b)carbazole promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 mRNA]]; 6-formylindolo(3,2-b)carbazole promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 protein]]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 mRNA]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 protein]

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

ATPase phospholipid transporting 10A (putative)

decreases expression

deoxynivalenol results in decreased expression of ATP10A mRNA

NCBI chr 1:109,556,760...109,730,440
Ensembl chr 1:109,556,782...109,730,437

G

ATP synthase F1 subunit gamma

decreases expression

deoxynivalenol results in decreased expression of ATP5F1C protein

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367

G

ATP synthase peripheral stalk subunit d

decreases expression

deoxynivalenol results in decreased expression of ATP5PD protein

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

ATPase H+ transporting V1 subunit A

decreases expression

deoxynivalenol results in decreased expression of ATP6V1A protein

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATPase H+ transporting V1 subunit B2

decreases expression

deoxynivalenol results in decreased expression of ATP6V1B2 protein

NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745

G

ATPase H+ transporting V1 subunit D

decreases expression

deoxynivalenol results in decreased expression of ATP6V1D protein

NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303

G

ATPase H+ transporting V1 subunit G1

decreases expression

deoxynivalenol results in decreased expression of ATP6V1G1 protein

NCBI chr 5:76,961,462...76,967,642
Ensembl chr 5:76,961,499...76,969,463

G

ATPase H+ transporting V1 subunit H

decreases expression

deoxynivalenol results in decreased expression of ATP6V1H protein

NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962

G

ATPase phospholipid transporting 8B2

decreases expression

deoxynivalenol results in decreased expression of ATP8B2 mRNA

NCBI chr 2:175,378,514...175,402,265
Ensembl chr 2:175,378,517...175,401,883

G

ATRX, chromatin remodeler

affects phosphorylation

deoxynivalenol affects the phosphorylation of ATRX protein

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

Beta-1,3-galactosyltransferase 4

decreases expression

deoxynivalenol results in decreased expression of B3GALT4 mRNA

NCBI chr20:4,936,089...4,937,664
Ensembl chr20:4,931,768...4,938,315

G

BTB domain and CNC homolog 2

increases expression

deoxynivalenol results in increased expression of BACH2 mRNA

NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877

G

BCL2-associated agonist of cell death

increases phosphorylation

deoxynivalenol results in increased phosphorylation of BAD protein

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 3

increases expression

deoxynivalenol results in increased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BCL2-antagonist/killer 1

increases expression

deoxynivalenol results in increased expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression
affects localization
decreases expression

[Zearalenone co-treated with deoxynivalenol] results in increased expression of BAX mRNA; [Zearalenone co-treated with deoxynivalenol] results in increased expression of BAX protein; Ascorbic Acid inhibits the reaction [deoxynivalenol results in increased expression of BAX protein]
Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX protein]; deoxynivalenol promotes the reaction [Zearalenone results in increased expression of BAX mRNA]
deoxynivalenol results in increased expression of BAX mRNA; deoxynivalenol results in increased expression of BAX protein
deoxynivalenol affects the localization of BAX protein
deoxynivalenol results in decreased expression of BAX mRNA

PMID:15976193 PMID:17166419 PMID:19410639 PMID:22269384 PMID:25445755 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression

deoxynivalenol results in increased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL10, immune signaling adaptor

increases expression

deoxynivalenol results in increased expression of BCL10 mRNA

NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523

G

BCL2, apoptosis regulator

multiple interactions
decreases expression
increases expression

Ascorbic Acid inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]
deoxynivalenol results in decreased expression of BCL2 mRNA; deoxynivalenol results in decreased expression of BCL2 protein
Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; deoxynivalenol promotes the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; Selenomethionine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]
deoxynivalenol results in increased expression of BCL2 mRNA

PMID:17166419 PMID:22269384 PMID:25445755 PMID:35817260 PMID:37705238 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

deoxynivalenol results in decreased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 13

increases expression

deoxynivalenol results in increased expression of BCL2L13 mRNA

NCBI chr 4:154,056,116...154,112,890
Ensembl chr 4:154,056,127...154,108,985

G

BCL6, transcription repressor

increases expression

deoxynivalenol results in increased expression of BCL6 mRNA

PMID:22968694 PMID:31863870

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

BCL2-associated transcription factor 1

increases expression
affects phosphorylation

deoxynivalenol results in increased expression of BCLAF1 mRNA
deoxynivalenol affects the phosphorylation of BCLAF1 protein

PMID:22846391 PMID:23352502 PMID:23811945

NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832

G

beclin 1

increases expression
decreases expression
multiple interactions

deoxynivalenol results in increased expression of BECN1 mRNA
deoxynivalenol results in decreased expression of BECN1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of BECN1 mRNA]]; 6-formylindolo(3,2-b)carbazole promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of BECN1 mRNA]]; Selenomethionine inhibits the reaction [deoxynivalenol results in decreased expression of BECN1 protein]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of BECN1 mRNA]

PMID:34677630 PMID:35381244 PMID:38040082

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

BEN domain containing 7

increases expression

deoxynivalenol results in increased expression of BEND7 mRNA

NCBI chr17:73,483,212...73,566,221
Ensembl chr17:73,485,282...73,567,559

G

BH3 interacting domain death agonist

decreases expression

deoxynivalenol results in decreased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

bridging integrator 1

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of BIN1 protein

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

G

basic helix-loop-helix ARNT like 1

multiple interactions

BMAL1 protein inhibits the reaction [deoxynivalenol results in increased activity of GOT1 protein]; BMAL1 protein inhibits the reaction [deoxynivalenol results in increased activity of GPT protein]; BMAL1 protein inhibits the reaction [deoxynivalenol results in increased expression of IL1B protein]; BMAL1 protein inhibits the reaction [deoxynivalenol results in increased expression of IL6 protein]; BMAL1 protein inhibits the reaction [deoxynivalenol results in increased expression of TNF protein]; BMAL1 protein promotes the reaction [deoxynivalenol results in decreased expression of CLOCK protein]; BMAL1 protein promotes the reaction [deoxynivalenol results in decreased expression of NR1D1 protein]; BMAL1 protein promotes the reaction [deoxynivalenol results in decreased expression of PER2 protein]; BMAL1 protein promotes the reaction [deoxynivalenol results in decreased expression of PER3 protein]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of CLOCK mRNA]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of CRY1 mRNA]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of CRY1 protein]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of CRY2 mRNA]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of CRY2 protein]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of NR1D1 mRNA]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of NR1D2 mRNA]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of PER1 mRNA]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of PER1 protein]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of PER3 mRNA]

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

bone morphogenetic protein 2

increases expression

deoxynivalenol results in increased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

BCL2 interacting protein 1

increases expression

deoxynivalenol results in increased expression of BNIP1 mRNA

NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157

G

BCL2 interacting protein 2

increases phosphorylation

deoxynivalenol results in increased phosphorylation of BNIP2 protein

NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:70,640,445...70,675,590

G

bromodomain PHD finger transcription factor

increases phosphorylation

deoxynivalenol results in increased phosphorylation of BPTF protein

NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769

G

bromodomain containing 3

increases phosphorylation

deoxynivalenol results in increased phosphorylation of BRD3 protein

NCBI chr 3:10,773,163...10,829,675
Ensembl chr 3:10,775,272...10,829,577

G

bone marrow stromal cell antigen 1

decreases expression

deoxynivalenol results in decreased expression of BST1 mRNA

NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180

G

BUB1 mitotic checkpoint serine/threonine kinase B

increases expression

deoxynivalenol results in increased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

BUB3 mitotic checkpoint protein

increases expression

deoxynivalenol results in increased expression of BUB3 mRNA

NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036

G

complement C3

increases expression

deoxynivalenol results in increased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C3a receptor 1

increases expression

deoxynivalenol results in increased expression of C3AR1 mRNA

PMID:12604170 PMID:22968694

NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701

G

complement C4B

increases expression

deoxynivalenol results in increased expression of C4B mRNA

NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681

G

calcium voltage-gated channel subunit alpha1 D

increases expression

deoxynivalenol results in increased expression of CACNA1D mRNA

NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215

G

calcium voltage-gated channel auxiliary subunit gamma 6

decreases expression

deoxynivalenol results in decreased expression of CACNG6 mRNA

NCBI chr 1:65,732,910...65,747,377
Ensembl chr 1:65,732,632...65,747,341

G

calnexin

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of CANX protein

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

caspase recruitment domain family, member 11

affects phosphorylation

deoxynivalenol affects the phosphorylation of CARD11 protein

NCBI chr12:13,621,140...13,758,115
Ensembl chr12:13,621,087...13,758,112

G

CASC3 exon junction complex subunit

increases phosphorylation

deoxynivalenol results in increased phosphorylation of CASC3 protein

NCBI chr10:83,769,014...83,788,966
Ensembl chr10:83,769,001...83,788,966

G

caspase 1

increases expression
increases cleavage
multiple interactions

deoxynivalenol results in increased expression of CASP1 mRNA
deoxynivalenol results in increased cleavage of CASP1 protein
deoxynivalenol promotes the reaction [fumonisin B1 results in increased cleavage of CASP1 protein]; fumonisin B1 promotes the reaction [deoxynivalenol results in increased cleavage of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases activity
increases cleavage
increases expression
multiple interactions
decreases expression

deoxynivalenol results in increased activity of CASP3 protein
deoxynivalenol results in increased cleavage of CASP3 protein
deoxynivalenol results in increased expression of CASP3 mRNA; deoxynivalenol results in increased expression of CASP3 protein
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [deoxynivalenol results in increased activity of CASP3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [deoxynivalenol results in increased expression of and results in increased cleavage of CASP3 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased expression of and results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; deoxynivalenol promotes the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; deoxynivalenol results in increased activity of and results in increased cleavage of CASP3 protein; deoxynivalenol results in increased expression of and results in increased cleavage of CASP3 protein; HCK protein affects the reaction [deoxynivalenol results in increased activity of CASP3 protein]; lauric acid inhibits the reaction [deoxynivalenol results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]
deoxynivalenol results in decreased expression of CASP3 protein
[Zearalenone co-treated with Aflatoxin B1] promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]; [Zearalenone co-treated with deoxynivalenol] results in increased expression of CASP3 protein; Aflatoxin B1 promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]; Ascorbic Acid inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [deoxynivalenol results in decreased expression of and results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [deoxynivalenol results in decreased expression of and results in increased cleavage of CASP3 protein]; deoxynivalenol results in decreased expression of and results in increased cleavage of CASP3 protein

PMID:15772366 PMID:15976193 PMID:17166419 PMID:19410639 PMID:19664677 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity

deoxynivalenol results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases expression
multiple interactions

deoxynivalenol results in increased expression of CASP8 mRNA
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased expression of CASP8 mRNA]
[Aflatoxin B1 co-treated with deoxynivalenol] promotes the reaction [Zearalenone results in increased expression of CASP8 mRNA]; [Aflatoxin B1 co-treated with deoxynivalenol] results in increased expression of CASP8 mRNA; [Zearalenone co-treated with Aflatoxin B1] promotes the reaction [deoxynivalenol results in increased expression of CASP8 mRNA]; [Zearalenone co-treated with deoxynivalenol] promotes the reaction [Aflatoxin B1 results in increased expression of CASP8 mRNA]; Zearalenone promotes the reaction [[Aflatoxin B1 co-treated with deoxynivalenol] results in increased expression of CASP8 mRNA]
deoxynivalenol results in increased activity of and results in increased cleavage of CASP8 protein

PMID:22491426 PMID:22846391 PMID:30668976 PMID:34673182

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

decreases expression
multiple interactions
increases expression
increases activity

deoxynivalenol results in decreased expression of CASP9 protein
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased expression of CASP9 mRNA]
Zearalenone promotes the reaction [[Aflatoxin B1 co-treated with deoxynivalenol] results in increased expression of CASP9 mRNA]
deoxynivalenol results in increased activity of and results in increased cleavage of CASP9 protein
deoxynivalenol results in increased expression of CASP9 mRNA; deoxynivalenol results in increased expression of CASP9 protein
deoxynivalenol results in increased activity of CASP9 protein

PMID:22269384 PMID:22491426 PMID:30668976 PMID:34673182 PMID:35314294

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calcium-sensing receptor

multiple interactions

CASR affects the reaction [deoxynivalenol results in increased secretion of CCK protein]

NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811

G

catalase

increases expression
decreases activity
multiple interactions
decreases expression
increases activity

deoxynivalenol results in increased expression of CAT mRNA; deoxynivalenol results in increased expression of CAT protein
deoxynivalenol results in decreased activity of CAT protein
Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CAT mRNA]
deoxynivalenol results in increased activity of CAT protein
Lutein inhibits the reaction [deoxynivalenol results in increased expression of CAT protein]

PMID:20347963 PMID:34400200 PMID:34673182 PMID:35314294 PMID:35817260 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cbl proto-oncogene like 1

increases expression

deoxynivalenol results in increased expression of CBLL1 mRNA

NCBI chr 6:48,071,190...48,086,174
Ensembl chr 6:48,071,190...48,086,444

G

cystathionine beta synthase

decreases expression

deoxynivalenol results in decreased expression of CBS mRNA

NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764

G

chromobox 5

increases phosphorylation

deoxynivalenol results in increased phosphorylation of CBX5 protein

NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022

G

coiled-coil domain containing 112

increases expression

deoxynivalenol results in increased expression of CCDC112 mRNA

NCBI chr18:38,998,139...39,032,329
Ensembl chr18:38,998,139...39,032,329

G

cholecystokinin

increases secretion
multiple interactions
increases expression

deoxynivalenol results in increased secretion of CCK protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]; 2-aminoethyl diphenylborinate inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]; [N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine co-treated with Ruthenium Red] inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]; CASR affects the reaction [deoxynivalenol results in increased secretion of CCK protein]; Egtazic Acid inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]; N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]; Nitrendipine inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]; triphenylphosphine oxide inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein]; TRPA1 affects the reaction [deoxynivalenol results in increased secretion of CCK protein]

PMID:22903826 PMID:24385417 PMID:25787141 PMID:26979077

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

C-C motif chemokine ligand 1

increases expression

deoxynivalenol results in increased expression of CCL1 mRNA

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 11

increases expression

deoxynivalenol results in increased expression of CCL11 mRNA

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 12

increases expression

deoxynivalenol results in increased expression of CCL12 mRNA

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

G

C-C motif chemokine ligand 17

increases expression

deoxynivalenol results in increased expression of CCL17 mRNA

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 2

increases expression
multiple interactions

deoxynivalenol results in increased expression of CCL2 mRNA; deoxynivalenol results in increased expression of CCL2 protein
Fatty Acids, Omega-3 inhibits the reaction [deoxynivalenol results in increased expression of CCL2 mRNA]

PMID:15371230 PMID:15681167 PMID:17090620 PMID:22846391 PMID:22968694 More...

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

increases expression

deoxynivalenol results in increased expression of CCL20 mRNA

PMID:27757495 PMID:35314294

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 22

increases expression

deoxynivalenol results in increased expression of CCL22 mRNA

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 24

increases expression

deoxynivalenol results in increased expression of CCL24 mRNA

NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893

G

C-C motif chemokine ligand 25

decreases expression

deoxynivalenol results in decreased expression of CCL25 mRNA

NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554

G

C-C motif chemokine ligand 3

increases expression

deoxynivalenol results in increased expression of CCL3 mRNA

PMID:22846391 PMID:22968694

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

increases expression

deoxynivalenol results in increased expression of CCL4 mRNA

PMID:21074547 PMID:22846391 PMID:22968694 PMID:27757495

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

increases expression
multiple interactions

deoxynivalenol results in increased expression of CCL5 mRNA
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased expression of CCL5 mRNA]

PMID:22968694 PMID:27757495 PMID:35925383

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

multiple interactions
increases expression

Fatty Acids, Omega-3 inhibits the reaction [deoxynivalenol results in increased expression of CCL7 mRNA]

PMID:15371230 PMID:15681167 PMID:22968694 PMID:24793808

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cellular communication network factor 1

increases expression

deoxynivalenol results in increased expression of CCN1 mRNA

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cellular communication network factor 2

increases expression

deoxynivalenol results in increased expression of CCN2 mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin B1

increases expression
multiple interactions

deoxynivalenol results in increased expression of CCNB1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of CCNB1 mRNA]

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

increases expression
multiple interactions

deoxynivalenol results in increased expression of CCND1 mRNA; deoxynivalenol results in increased expression of CCND1 protein
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of CCND1 protein]

PMID:22454431 PMID:24937323 PMID:32416088

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

decreases expression

deoxynivalenol results in decreased expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin G2

increases expression

deoxynivalenol results in increased expression of CCNG2 mRNA

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

cyclin Y

affects phosphorylation

deoxynivalenol affects the phosphorylation of CCNY protein

NCBI chr17:57,385,002...57,512,860
Ensembl chr17:57,384,176...57,522,378

G

C-C motif chemokine receptor 1

increases expression

deoxynivalenol results in increased expression of CCR1 mRNA

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 2

increases expression

deoxynivalenol results in increased expression of CCR2 mRNA

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 3

increases expression

deoxynivalenol results in increased expression of CCR3 mRNA

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

C-C motif chemokine receptor 4

increases expression

deoxynivalenol results in increased expression of CCR4 mRNA

NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056

G

C-C motif chemokine receptor 7

increases expression

deoxynivalenol results in increased expression of CCR7 mRNA

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

CD14 molecule

multiple interactions

deoxynivalenol inhibits the reaction [IFNG protein results in increased expression of CD14 protein]

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD248 molecule

decreases expression

deoxynivalenol results in decreased expression of CD248 mRNA

NCBI chr 1:202,373,676...202,376,240
Ensembl chr 1:202,373,676...202,376,240

G

CD40 molecule

decreases expression

deoxynivalenol results in decreased expression of CD40 mRNA

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD55 molecule (Cromer blood group)

increases expression

deoxynivalenol results in increased expression of CD55 mRNA

PMID:22846391 PMID:24247028

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

Cd68 molecule

increases expression

deoxynivalenol results in increased expression of CD68 mRNA

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

Cd69 molecule

increases expression

deoxynivalenol results in increased expression of CD69 mRNA

PMID:22846391 PMID:24247028

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

G

Cd80 molecule

increases expression

deoxynivalenol results in increased expression of CD80 mRNA

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

increases expression

deoxynivalenol results in increased expression of CD86 mRNA

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

codanin 1

increases expression

deoxynivalenol results in increased expression of CDAN1 mRNA

NCBI chr 3:107,675,147...107,689,811
Ensembl chr 3:107,673,645...107,689,773

G

cadherin 13

decreases expression

deoxynivalenol results in decreased expression of CDH13 mRNA

NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459

G

cyclin-dependent kinase 1

increases expression
multiple interactions

deoxynivalenol results in increased expression of CDK1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of CDK1 mRNA]

PMID:31863870 PMID:34677630

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions
decreases degradation

deoxynivalenol results in increased expression of CDKN1A mRNA; deoxynivalenol results in increased expression of CDKN1A protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of CDKN1A mRNA]; EGR1 protein affects the reaction [deoxynivalenol results in increased expression of CDKN1A protein]; U 0126 inhibits the reaction [deoxynivalenol results in decreased degradation of CDKN1A mRNA]

PMID:18006205 PMID:22454431 PMID:30169763 PMID:30286430 PMID:31863870 More...

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 3

increases expression

deoxynivalenol results in increased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

CCAAT/enhancer binding protein alpha

multiple interactions
decreases expression

[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CEBPA mRNA
deoxynivalenol results in decreased expression of CEBPA mRNA

PMID:28865950 PMID:28935499

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

multiple interactions
increases activity
affects localization

4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased activity of CEBPB protein]
deoxynivalenol affects the localization of CEBPB protein

PMID:12604842 PMID:15772366

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

centromere protein W

increases expression

deoxynivalenol results in increased expression of CENPW mRNA

NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464

G

cerebral endothelial cell adhesion molecule

decreases expression

deoxynivalenol results in decreased expression of CERCAM mRNA

NCBI chr 3:13,118,150...13,155,960
Ensembl chr 3:13,142,107...13,155,956

G

cell growth regulator with EF hand domain 1

decreases expression

deoxynivalenol results in decreased expression of CGREF1 mRNA

NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

decreases expression

deoxynivalenol results in decreased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

chromosome alignment maintaining phosphoprotein 1

affects phosphorylation

deoxynivalenol affects the phosphorylation of CHAMP1 protein

NCBI chr16:75,733,958...75,744,931
Ensembl chr16:75,733,805...75,744,984

G

choline kinase alpha

increases expression

deoxynivalenol results in increased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

chimerin 1

decreases expression

deoxynivalenol results in decreased expression of CHN1 mRNA

NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490

G

cysteine and histidine rich domain containing 1

increases expression

deoxynivalenol results in increased expression of CHORDC1 mRNA

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

component of inhibitor of nuclear factor kappa B kinase complex

increases phosphorylation
increases expression

deoxynivalenol results in increased phosphorylation of CHUK protein
deoxynivalenol results in increased expression of CHUK mRNA

PMID:20633634 PMID:34400200

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cytokine inducible SH2-containing protein

increases expression

deoxynivalenol results in increased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

cytoskeleton associated protein 2

increases expression

deoxynivalenol results in increased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

cytoskeleton associated protein 5

increases expression

deoxynivalenol results in increased expression of CKAP5 mRNA

NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264

G

CDC28 protein kinase regulatory subunit 1B

increases expression

deoxynivalenol results in increased expression of CKS1B mRNA

NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636

G

claudin 1

increases expression
decreases expression
multiple interactions
affects expression

deoxynivalenol results in increased expression of CLDN1 mRNA
deoxynivalenol results in decreased expression of CLDN1 mRNA; deoxynivalenol results in decreased expression of CLDN1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]]; 6-formylindolo(3,2-b)carbazole inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]]; 6-formylindolo(3,2-b)carbazole inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]; lauric acid inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]; sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]; sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]
[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 mRNA; [deoxynivalenol co-treated with Zearalenone] results in decreased expression of CLDN1 protein; deoxynivalenol results in decreased expression of and affects the localization of CLDN1 protein
deoxynivalenol affects the expression of CLDN1 protein

PMID:24568843 PMID:28865950 PMID:28935499 PMID:34506767 PMID:35381244 More...

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

claudin 2

affects expression
increases expression

deoxynivalenol affects the expression of CLDN2 protein
deoxynivalenol results in increased expression of CLDN2 mRNA

NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838

G

claudin 3

multiple interactions
increases expression
affects expression

deoxynivalenol results in decreased expression of and affects the localization of CLDN3 protein
[deoxynivalenol results in increased susceptibility to Antigens] which results in decreased expression of CLDN3 mRNA
deoxynivalenol results in increased expression of CLDN3 mRNA
deoxynivalenol affects the expression of CLDN3 protein

PMID:24568843 PMID:28935500

NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001

G

claudin 4

decreases expression
increases expression
multiple interactions

deoxynivalenol results in decreased expression of CLDN4 protein
deoxynivalenol results in increased expression of CLDN4 mRNA
deoxynivalenol results in decreased expression of and affects the localization of CLDN4 protein

PMID:19289138 PMID:20362602 PMID:24568843

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

chloride intracellular channel 3

decreases expression

deoxynivalenol results in decreased expression of CLIC3 mRNA

NCBI chr 3:8,271,416...8,274,023
Ensembl chr 3:8,272,097...8,274,018

G

clock circadian regulator

multiple interactions
decreases expression

BMAL1 protein promotes the reaction [deoxynivalenol results in decreased expression of CLOCK protein]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of CLOCK mRNA]

NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400

G

canopy FGF signaling regulator 2

decreases expression

deoxynivalenol results in decreased expression of CNPY2 mRNA

NCBI chr 7:748,877...754,352
Ensembl chr 7:749,008...755,519

G

collagen type XV alpha 1 chain

decreases expression

deoxynivalenol results in decreased expression of COL15A1 mRNA

NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591

G

collagen type IV alpha 1 chain

decreases expression

deoxynivalenol results in decreased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type V alpha 1 chain

decreases expression

deoxynivalenol results in decreased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

collagen type VI alpha 2 chain

decreases expression

deoxynivalenol results in decreased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

catechol-O-methyltransferase

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of COMT protein

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

coronin 1A

affects phosphorylation

deoxynivalenol affects the phosphorylation of CORO1A protein

NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534

G

coronin 2B

decreases expression

deoxynivalenol results in decreased expression of CORO2B mRNA

NCBI chr 8:62,906,861...63,017,295
Ensembl chr 8:62,906,867...63,017,302

G

cytochrome c oxidase subunit 5B

decreases expression

deoxynivalenol results in decreased expression of COX5B protein

NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052

G

cleavage and polyadenylation specific factor 2

increases expression

deoxynivalenol results in increased expression of CPSF2 mRNA

NCBI chr 6:121,123,941...121,152,756
Ensembl chr 6:121,120,569...121,151,921

G

cAMP responsive element binding protein 1

multiple interactions
increases phosphorylation
increases activity
affects localization

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]; AKT1 protein affects the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]; Celecoxib inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]; deoxynivalenol promotes the reaction [CREB1 protein modified form binds to IL6 promoter]; Docosahexaenoic Acids inhibits the reaction [deoxynivalenol promotes the reaction [CREB1 protein modified form binds to IL6 promoter]]; Docosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased activity of CREB1 protein]; Docosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]
deoxynivalenol affects the localization of CREB1 protein

PMID:12604842 PMID:16424113 PMID:32416088

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element binding protein 5

increases expression

deoxynivalenol results in increased expression of CREB5 mRNA

NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325

G

CREB binding protein

increases expression

deoxynivalenol results in increased expression of CREBBP mRNA

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

cysteine-rich with EGF-like domains 1

decreases expression

deoxynivalenol results in decreased expression of CRELD1 mRNA

NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499

G

C-reactive protein

increases expression

deoxynivalenol results in increased expression of CRP mRNA

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

cryptochrome circadian regulator 1

multiple interactions

deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of CRY1 mRNA]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of CRY1 protein]

NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091

G

cryptochrome circadian regulator 2

multiple interactions

deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of CRY2 mRNA]; deoxynivalenol inhibits the reaction [BMAL1 protein results in increased expression of CRY2 protein]

NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965

G

colony stimulating factor 3

increases expression

deoxynivalenol results in increased expression of CSF3 mRNA

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

collagen triple helix repeat containing 1

decreases expression

deoxynivalenol results in decreased expression of CTHRC1 mRNA

NCBI chr 7:70,122,474...70,132,756
Ensembl chr 7:70,122,474...70,132,756

G

catenin alpha 1

decreases expression

deoxynivalenol results in decreased expression of CTNNA1 protein

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

catenin beta 1

affects phosphorylation

deoxynivalenol affects the phosphorylation of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin O

decreases expression

deoxynivalenol results in decreased expression of CTSO mRNA

NCBI chr 2:167,230,407...167,254,761
Ensembl chr 2:167,230,330...167,253,702

G

CWF19 like cell cycle control factor 2

increases expression

deoxynivalenol results in increased expression of CWF19L2 mRNA

NCBI chr 6:290,148...356,636
Ensembl chr 6:281,685...356,604

G

C-X3-C motif chemokine ligand 1

increases expression

deoxynivalenol results in increased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 1

multiple interactions
increases expression

[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of CXCL1 mRNA]; ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA]

PMID:22003189 PMID:27757495

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

decreases expression
increases expression

deoxynivalenol results in decreased expression of CXCL10 mRNA
deoxynivalenol results in increased expression of CXCL10 mRNA; deoxynivalenol results in increased expression of CXCL10 protein

PMID:15371230 PMID:22968694 PMID:34400200

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 11

decreases expression
increases expression

deoxynivalenol results in decreased expression of CXCL11 mRNA
deoxynivalenol results in increased expression of CXCL11 mRNA

PMID:22968694 PMID:27757495

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

G

C-X-C motif chemokine ligand 2

increases expression
multiple interactions

deoxynivalenol results in increased expression of CXCL2 mRNA; deoxynivalenol results in increased expression of CXCL2 protein
deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Fatty Acids, Omega-3 inhibits the reaction [deoxynivalenol results in increased expression of CXCL2 mRNA]

PMID:12604170 PMID:15371230 PMID:15681167 PMID:22968694 PMID:24793808 More...

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions
increases expression

[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of CXCL1 mRNA]; ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA]
deoxynivalenol results in increased expression of CXCL1 mRNA; deoxynivalenol results in increased expression of CXCL3 mRNA

PMID:15371230 PMID:15681167 PMID:22003189 PMID:22968694 PMID:27757495

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 9

increases expression

deoxynivalenol results in increased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

C-X-C motif chemokine receptor 1

increases expression

deoxynivalenol results in increased expression of CXCR1 mRNA

NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084

G

C-X-C motif chemokine receptor 2

increases expression

deoxynivalenol results in increased expression of CXCR2 mRNA

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

C-X-C motif chemokine receptor 4

increases expression

deoxynivalenol results in increased expression of CXCR4 mRNA

PMID:22846391 PMID:27757495

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome c-1

decreases expression

deoxynivalenol results in decreased expression of CYC1 protein

NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479

G

cytochrome c, somatic

affects localization
increases expression
decreases expression
increases activity

deoxynivalenol affects the localization of CYCS protein
deoxynivalenol results in increased expression of CYCS mRNA; deoxynivalenol results in increased expression of CYCS protein
deoxynivalenol results in decreased expression of CYCS protein
deoxynivalenol results in increased activity of CYCS protein

PMID:15976193 PMID:22269384 PMID:22846391

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily b, polypeptide 2

increases expression

deoxynivalenol results in increased expression of CYP11B1 mRNA

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

increases expression

deoxynivalenol results in increased expression of CYP11B2 mRNA

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression

deoxynivalenol results in increased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases expression

deoxynivalenol results in decreased expression of CYP19A1 mRNA

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

deoxynivalenol results in increased expression of CYP1A1 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of CYP1A1 mRNA]]; 6-formylindolo(3,2-b)carbazole promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of CYP1A1 mRNA]]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of CYP1A1 mRNA]

PMID:22982764 PMID:35381244

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases expression

deoxynivalenol results in decreased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects expression
multiple interactions

deoxynivalenol affects the expression of CYP3A4 mRNA
[deoxynivalenol co-treated with Zearalenone] affects the expression of CYP3A4 mRNA; [deoxynivalenol co-treated with Zearalenone] results in decreased expression of CYP3A4 protein; [deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP3A4 mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP3A4 protein

PMID:28865950 PMID:28935499

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 4, subfamily f, polypeptide 18

multiple interactions

[deoxynivalenol co-treated with Zearalenone] results in decreased expression of CYP4F3 mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of CYP4F3 mRNA

PMID:28865950 PMID:28935499

NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940

G

cytokine like 1

decreases expression

deoxynivalenol results in decreased expression of CYTL1 mRNA

NCBI chr14:73,053,876...73,058,886
Ensembl chr14:73,053,877...73,058,886

G

damage specific DNA binding protein 2

increases expression

deoxynivalenol results in increased expression of DDB2 mRNA

NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631

G

DNA-damage inducible transcript 3

increases expression
decreases expression

deoxynivalenol results in increased expression of DDIT3 mRNA
deoxynivalenol results in decreased expression of DDIT3 mRNA

PMID:22846391 PMID:23253260 PMID:30169763

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

decreases expression

deoxynivalenol results in decreased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

DExD-box helicase 21

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of DDX21 protein

PMID:23352502 PMID:23811945

NCBI chr20:30,534,319...30,554,513
Ensembl chr20:30,534,319...30,554,543

G

DExD-box helicase 39A

increases expression

deoxynivalenol results in increased expression of DDX39A mRNA

NCBI chr19:24,418,743...24,427,422
Ensembl chr19:24,418,114...24,426,954

G

DExD-box helicase 52

increases expression

deoxynivalenol results in increased expression of DDX52 mRNA

NCBI chr10:68,824,594...68,847,400
Ensembl chr10:68,824,645...68,848,266

G

DEP domain containing MTOR-interacting protein

decreases expression

deoxynivalenol results in decreased expression of DEPTOR mRNA

NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773

G

DNA fragmentation factor subunit alpha

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of DFFA protein

NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633

G

diacylglycerol kinase, gamma

multiple interactions

[Selenomethionine co-treated with deoxynivalenol] results in increased expression of DGKG mRNA

NCBI chr11:78,384,212...78,579,158
Ensembl chr11:78,384,458...78,577,212

G

diacylglycerol kinase, iota

multiple interactions

[Selenomethionine co-treated with deoxynivalenol] results in increased expression of DGKI mRNA

NCBI chr 4:65,410,878...65,872,733
Ensembl chr 4:65,420,108...65,872,733

G

dyskerin pseudouridine synthase 1

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of DKC1 protein

G

dynein, axonemal, heavy chain 10

affects phosphorylation

deoxynivalenol affects the phosphorylation of DNAH10 protein

NCBI chr12:31,823,451...31,946,857
Ensembl chr12:31,822,733...32,007,069

G

DnaJ heat shock protein family (Hsp40) member A1

increases expression
decreases expression

deoxynivalenol results in increased expression of DNAJA1 mRNA
deoxynivalenol results in decreased expression of DNAJA1 protein

PMID:15371230 PMID:33890134

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member C1

increases expression

deoxynivalenol results in increased expression of DNAJC1 mRNA

NCBI chr17:80,955,209...81,112,025
Ensembl chr17:80,955,237...81,111,988

G

DnaJ heat shock protein family (Hsp40) member C3

multiple interactions
decreases expression

deoxynivalenol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DNAJC3 mRNA]
deoxynivalenol results in decreased expression of DNAJC3 mRNA

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

DnaJ heat shock protein family (Hsp40) member C5

increases phosphorylation

deoxynivalenol results in increased phosphorylation of DNAJC5 protein

NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935

G

DNA methyltransferase 1

affects phosphorylation
increases expression

deoxynivalenol affects the phosphorylation of DNMT1 protein
deoxynivalenol results in increased expression of DNMT1 mRNA; deoxynivalenol results in increased expression of DNMT1 protein

PMID:23352502 PMID:23811945 PMID:32738333

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

increases expression

deoxynivalenol results in increased expression of DNMT3A mRNA; deoxynivalenol results in increased expression of DNMT3A protein

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

deoxynucleotidyltransferase, terminal, interacting protein 2

increases expression

deoxynivalenol results in increased expression of DNTTIP2 mRNA

NCBI chr 2:210,374,321...210,386,366
Ensembl chr 2:210,374,289...210,385,581

G

desmocollin 1

increases expression

deoxynivalenol results in increased expression of DSC1 protein

NCBI chr18:11,499,936...11,556,801
Ensembl chr18:11,502,003...11,528,494

G

dual specificity phosphatase 1

increases expression
multiple interactions

deoxynivalenol results in increased expression of DUSP1 mRNA; deoxynivalenol results in increased expression of DUSP1 protein
Fatty Acids, Omega-3 promotes the reaction [deoxynivalenol results in increased expression of DUSP1 mRNA]
[deoxynivalenol results in increased expression of DUSP1 protein] which results in decreased activity of MAPK8 protein; [deoxynivalenol results in increased expression of DUSP1 protein] which results in decreased activity of MAPK9 protein

PMID:15371230 PMID:15681167 PMID:20708668

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 6

decreases expression

deoxynivalenol results in decreased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

dual specificity phosphatase 8

increases expression

deoxynivalenol results in increased expression of DUSP8 mRNA

NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921

G

dynein cytoplasmic 1 light intermediate chain 1

increases phosphorylation

deoxynivalenol results in increased phosphorylation of DYNC1LI1 protein

NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934

G

extracellular matrix protein 1

decreases expression

deoxynivalenol results in decreased expression of ECM1 mRNA

NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671

G

epithelial cell transforming 2

increases expression

deoxynivalenol results in increased expression of ECT2 mRNA

NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911

G

eukaryotic translation elongation factor 1 beta 2

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of EEF1B2 protein

NCBI chr 9:64,580,163...64,582,737
Ensembl chr 9:64,579,893...64,582,737

G

eukaryotic translation elongation factor 1 delta

increases phosphorylation

deoxynivalenol results in increased phosphorylation of EEF1D protein

NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799

G

epidermal growth factor

increases expression

deoxynivalenol results in increased expression of EGF mRNA

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

decreases expression

deoxynivalenol results in decreased expression of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

increases expression
multiple interactions

[deoxynivalenol results in increased expression of EGR1 protein] which results in increased expression of CXCL8 protein; deoxynivalenol results in increased expression of EGR1 mRNA; deoxynivalenol results in increased expression of EGR1 protein
ATF3 protein affects the reaction [deoxynivalenol results in increased expression of EGR1 protein]; deoxynivalenol results in increased expression of and results in increased phosphorylation of EGR1 protein; EGR1 protein affects the reaction [deoxynivalenol results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [deoxynivalenol results in increased expression of PPARG mRNA]

PMID:17707346 PMID:18485432 PMID:19360757 PMID:30286430 PMID:33890134

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

EP300 interacting inhibitor of differentiation 2

increases expression

deoxynivalenol results in increased expression of EID2 mRNA

NCBI chr 1:83,538,274...83,539,599

G

eukaryotic translation initiation factor 2A

increases phosphorylation

deoxynivalenol results in increased phosphorylation of EIF2A protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2-alpha kinase 2

decreases expression
affects response to substance
multiple interactions

deoxynivalenol results in decreased expression of EIF2AK2 mRNA
EIF2AK2 protein affects the susceptibility to deoxynivalenol
EIF2AK2 protein affects the reaction [deoxynivalenol results in increased activity of RELA protein]; EIF2AK2 protein affects the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]

PMID:17090620 PMID:18599499 PMID:22491426

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

G

eukaryotic translation initiation factor 2B subunit delta

increases expression

deoxynivalenol results in increased expression of EIF2B4 mRNA

NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829

G

eukaryotic translation initiation factor 2 subunit beta

affects expression

deoxynivalenol affects the expression of EIF2S2 mRNA

NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432

G

eukaryotic translation initiation factor 3, subunit B

affects phosphorylation

deoxynivalenol affects the phosphorylation of EIF3B protein

NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886

G

eukaryotic translation initiation factor 3, subunit C

affects phosphorylation

deoxynivalenol affects the phosphorylation of EIF3C protein

NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 4E binding protein 1

increases phosphorylation

deoxynivalenol results in increased phosphorylation of EIF4EBP1 protein

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 4 gamma 1

increases phosphorylation

deoxynivalenol results in increased phosphorylation of EIF4G1 protein

NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941

G

eukaryotic translation initiation factor 5B

affects phosphorylation

deoxynivalenol affects the phosphorylation of EIF5B protein

NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482

G

ELAV like RNA binding protein 1

multiple interactions

[[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] which co-treated with deoxynivalenol] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the localization of ELAVL1 protein; [deoxynivalenol results in increased expression of ELAVL1 protein] which results in decreased degradation of CXCL8 mRNA; deoxynivalenol results in increased expression of and results in increased localization of ELAVL1 protein; ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA]; ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL8 mRNA]; ELAVL1 protein affects the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]; ELAVL1 protein affects the reaction [deoxynivalenol results in increased expression of CXCL8 protein]

PMID:19591856 PMID:22003189

NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784

G

ETS transcription factor ELK1

increases expression

deoxynivalenol results in increased expression of ELK1 protein

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

ER membrane protein complex subunit 10

decreases expression

deoxynivalenol results in decreased expression of EMC10 mRNA

NCBI chr 1:94,980,260...94,988,847
Ensembl chr 1:94,943,587...94,988,847

G

elastin microfibril interfacer 1

decreases expression

deoxynivalenol results in decreased expression of EMILIN1 mRNA

NCBI chr 6:25,455,974...25,463,713
Ensembl chr 6:25,445,298...25,463,698

G

endoglin

decreases expression

deoxynivalenol results in decreased expression of ENG mRNA

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

endo-beta-N-acetylglucosaminidase

increases expression

deoxynivalenol results in increased expression of ENGASE mRNA

NCBI chr10:103,707,169...103,719,833
Ensembl chr10:103,707,169...103,719,819

G

E1A binding protein p300

multiple interactions
increases expression

EP300 protein affects the reaction [deoxynivalenol results in increased expression of ATF3 protein alternative form]
deoxynivalenol results in increased expression of EP300 protein

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

E1A binding protein p400

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of EP400 protein

NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861

G

erythrocyte membrane protein band 4.1-like 2

affects phosphorylation

deoxynivalenol affects the phosphorylation of EPB41L2 protein

NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721

G

epoxide hydrolase 1

decreases expression

deoxynivalenol results in decreased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

endoplasmic reticulum to nucleus signaling 1

decreases expression
increases expression

deoxynivalenol results in decreased expression of ERN1 mRNA
deoxynivalenol results in increased expression of ERN1 protein

PMID:19336499 PMID:20682335

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

estrogen receptor 1

multiple interactions
increases phosphorylation

ESR1 promotes the reaction [deoxynivalenol results in increased expression of PGR mRNA]; ESR1 promotes the reaction [deoxynivalenol results in increased expression of TFF1 mRNA]
deoxynivalenol results in increased phosphorylation of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

ethanolamine kinase 1

increases expression

deoxynivalenol results in increased expression of ETNK1 mRNA

NCBI chr 4:176,126,056...176,170,325
Ensembl chr 4:176,126,180...176,193,770

G

ecotropic viral integration site 2A

increases expression

deoxynivalenol results in increased expression of EVI2A mRNA

NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843

G

Enah/Vasp-like

affects phosphorylation

deoxynivalenol affects the phosphorylation of EVL protein

NCBI chr 6:127,473,119...127,594,342
Ensembl chr 6:127,474,543...127,594,344

G

exosome component 2

increases expression

deoxynivalenol results in increased expression of EXOSC2 mRNA

NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575

G

coagulation factor III, tissue factor

decreases expression

deoxynivalenol results in decreased expression of F3 mRNA

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid binding protein 3

decreases expression

deoxynivalenol results in decreased expression of FABP3 mRNA

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

fatty acid binding protein 4

decreases expression

deoxynivalenol results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid binding protein 6

decreases expression

deoxynivalenol results in decreased expression of FABP6 mRNA

NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282

G

family with sequence similarity 83, member D

increases expression

deoxynivalenol results in increased expression of FAM83D mRNA

NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192

G

Fas cell surface death receptor

multiple interactions
increases expression

Bentonite inhibits the reaction [deoxynivalenol results in increased expression of FAS protein]; Charcoal inhibits the reaction [deoxynivalenol results in increased expression of FAS protein]
deoxynivalenol results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

deoxynivalenol results in increased expression of FASL mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

FAST kinase domains 2

increases expression

deoxynivalenol results in increased expression of FASTKD2 mRNA

NCBI chr 9:65,166,148...65,188,184
Ensembl chr 9:65,168,228...65,188,174

G

F-box protein 22

increases expression

deoxynivalenol results in increased expression of FBXO22 mRNA

NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148

G

F-box protein 28

increases expression

deoxynivalenol results in increased expression of FBXO28 mRNA

NCBI chr13:93,995,993...94,021,464
Ensembl chr13:93,995,996...94,021,464

G

farnesyl diphosphate farnesyl transferase 1

decreases expression

deoxynivalenol results in decreased expression of FDFT1 protein

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

decreases expression

deoxynivalenol results in decreased expression of FDPS protein

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

filamin A

decreases phosphorylation
increases phosphorylation

deoxynivalenol results in decreased phosphorylation of FLNA protein
deoxynivalenol results in increased phosphorylation of FLNA protein

NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052

G

formin-like 1

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of FMNL1 protein

NCBI chr10:88,115,876...88,143,342
Ensembl chr10:88,116,009...88,143,357

G

fibromodulin

decreases expression

deoxynivalenol results in decreased expression of FMOD mRNA

NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133

G

fibronectin 1

decreases expression

deoxynivalenol results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

formin binding protein 1

decreases expression

deoxynivalenol results in decreased expression of FNBP1 mRNA

NCBI chr 3:14,309,067...14,424,378
Ensembl chr 3:14,309,640...14,424,881

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions
affects activity

deoxynivalenol results in increased expression of FOS mRNA
deoxynivalenol inhibits the reaction [Cadmium Chloride results in decreased expression of FOS mRNA]
Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of FOS protein]
deoxynivalenol affects the activity of FOS protein
deoxynivalenol results in increased expression of FOS mRNA; deoxynivalenol results in increased expression of FOS protein

PMID:10662601 PMID:15371230 PMID:15681167 PMID:19360757 PMID:21873375 More...

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

affects activity
multiple interactions
increases expression

deoxynivalenol affects the activity of FOSB protein
[Cadmium Chloride co-treated with deoxynivalenol] results in increased expression of FOSB mRNA
deoxynivalenol results in increased expression of FOSB mRNA

PMID:10662601 PMID:33309878

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions

[Cadmium Chloride co-treated with deoxynivalenol] results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

multiple interactions
increases expression
affects activity

Fatty Acids, Omega-3 inhibits the reaction [deoxynivalenol results in increased expression of FOSL2 mRNA]
deoxynivalenol results in increased expression of FOSL2 mRNA; deoxynivalenol results in increased expression of FOSL2 protein
[Cadmium Chloride co-treated with deoxynivalenol] results in increased expression of FOSL2 mRNA
deoxynivalenol affects the activity of FOSL2 protein

PMID:10662601 PMID:15371230 PMID:15681167 PMID:33309878 PMID:33890134

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box O1

increases phosphorylation

deoxynivalenol results in increased phosphorylation of FOXO1 protein

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box P3

increases expression

deoxynivalenol results in increased expression of FOXP3 mRNA

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

alpha-L-fucosidase 1

decreases expression

deoxynivalenol results in decreased expression of FUCA1 mRNA

NCBI chr 5:148,152,718...148,169,972
Ensembl chr 5:148,152,700...148,169,972

G

fucosyltransferase 1

decreases expression

deoxynivalenol results in decreased expression of FUT1 mRNA

NCBI chr 1:96,086,934...96,090,352
Ensembl chr 1:96,086,635...96,090,616

G

G3BP stress granule assembly factor 1

decreases phosphorylation
increases phosphorylation

deoxynivalenol results in decreased phosphorylation of G3BP1 protein
deoxynivalenol results in increased phosphorylation of G3BP1 protein

PMID:23352502 PMID:23811945

NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268

G

G3BP stress granule assembly factor 2

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of G3BP2 protein

NCBI chr14:15,932,403...16,020,555
Ensembl chr14:15,987,417...16,020,548

G

GA binding protein transcription factor subunit alpha

decreases expression

deoxynivalenol results in decreased expression of GABPA protein

NCBI chr11:23,888,586...23,917,612
Ensembl chr11:23,888,815...23,917,605

G

growth arrest and DNA-damage-inducible, alpha

increases expression

deoxynivalenol results in increased expression of GADD45A mRNA

PMID:30169763 PMID:31863870

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

polypeptide N-acetylgalactosaminyltransferase 1

decreases expression

deoxynivalenol results in decreased expression of GALNT1 mRNA

NCBI chr18:15,489,015...15,568,849
Ensembl chr18:15,489,020...15,568,245

G

galanin-like peptide

multiple interactions
increases expression

GALP protein promotes the reaction [deoxynivalenol results in increased expression of IL11 protein]; GALP protein promotes the reaction [deoxynivalenol results in increased expression of IL1B protein]; GALP protein promotes the reaction [deoxynivalenol results in increased expression of IL6 protein]
deoxynivalenol results in increased expression of GALP mRNA; deoxynivalenol results in increased expression of GALP protein

NCBI chr 1:67,684,023...67,703,121
Ensembl chr 1:67,684,025...67,702,269

G

galanin receptor 2

increases expression

deoxynivalenol results in increased expression of GALR2 mRNA

NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176

G

galanin receptor 3

increases expression

deoxynivalenol results in increased expression of GALR3 mRNA

NCBI chr 7:110,603,525...110,608,429
Ensembl chr 7:110,605,226...110,607,685

G

GATA zinc finger domain containing 2A

affects phosphorylation

deoxynivalenol affects the phosphorylation of GATAD2A protein

NCBI chr16:19,429,578...19,520,320
Ensembl chr16:19,429,578...19,519,587

G

glucagon

multiple interactions
increases expression
increases secretion

1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]; 2-aminoethyl diphenylborinate inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]; Egtazic Acid inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]; Nitrendipine inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]; triphenylphosphine oxide inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form]
deoxynivalenol results in increased expression of GCG protein

PMID:25787141 PMID:28633506

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glutamate-cysteine ligase, catalytic subunit

decreases expression
multiple interactions

deoxynivalenol results in decreased expression of GCLC mRNA
Resveratrol inhibits the reaction [deoxynivalenol results in decreased expression of GCLC protein]
Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of GCLC mRNA]

PMID:35817260 PMID:37419272

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

deoxynivalenol results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

growth differentiation factor 5

increases expression

deoxynivalenol results in increased expression of GDF5 mRNA

NCBI chr 3:144,454,316...144,458,508
Ensembl chr 3:144,454,338...144,458,612

G

growth hormone 1

multiple interactions
decreases secretion
decreases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; deoxynivalenol results in decreased expression of and results in decreased secretion of GH1 protein; farnesylthiosalicylic acid inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; farnesylthiosalicylic acid inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]; pyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; pyrazolanthrone inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased expression of GH1 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in decreased expression of GH1 protein]
deoxynivalenol results in decreased secretion of GH1 protein

PMID:26141394 PMID:32738333 PMID:34673182

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

growth hormone receptor

affects expression

deoxynivalenol affects the expression of GHR mRNA

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

growth hormone releasing hormone

increases expression

deoxynivalenol results in increased expression of GHRH mRNA

NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889

G

gastric inhibitory polypeptide

increases expression

deoxynivalenol results in increased expression of GIP protein

NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503

G

G kinase anchoring protein 1

increases expression

deoxynivalenol results in increased expression of GKAP1 mRNA

NCBI chr17:6,383,963...6,423,684
Ensembl chr17:6,383,963...6,423,679

G

gliomedin

decreases expression

deoxynivalenol results in decreased expression of GLDN mRNA

NCBI chr 8:54,679,015...54,723,198
Ensembl chr 8:54,679,119...54,723,196

G

glutamic-oxaloacetic transaminase 1

multiple interactions
increases activity

BMAL1 protein inhibits the reaction [deoxynivalenol results in increased activity of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glycoprotein Ib platelet subunit beta

affects phosphorylation

deoxynivalenol affects the phosphorylation of GP1BB protein

NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392

G

G patch domain and KOW motifs

increases expression

deoxynivalenol results in increased expression of GPKOW mRNA

NCBI chr X:14,791,601...14,806,384
Ensembl chr X:14,791,610...14,806,384

G

GPN-loop GTPase 1

increases phosphorylation

deoxynivalenol results in increased phosphorylation of GPN1 protein

NCBI chr 6:24,947,350...24,965,025
Ensembl chr 6:24,947,325...24,965,031

G

glutamic--pyruvic transaminase

multiple interactions
increases expression
increases activity

acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [deoxynivalenol results in increased activity of GPT protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased activity of GPT protein]; BMAL1 protein inhibits the reaction [deoxynivalenol results in increased activity of GPT protein]; deoxynivalenol promotes the reaction [Aflatoxin B1 results in increased activity of GPT protein]
Bentonite inhibits the reaction [deoxynivalenol results in increased expression of GPT protein]; Charcoal inhibits the reaction [deoxynivalenol results in increased expression of GPT protein]

PMID:25445755 PMID:26115597 PMID:34400200 PMID:35925383 PMID:36602574

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

increases phosphorylation
increases expression

deoxynivalenol results in increased phosphorylation of GPX1 protein
deoxynivalenol results in increased expression of GPX1 mRNA

PMID:23811945 PMID:34400200

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 4

multiple interactions
decreases expression

Resveratrol inhibits the reaction [deoxynivalenol results in decreased expression of GPX4 protein]
Selenomethionine inhibits the reaction [deoxynivalenol results in decreased expression of GPX4 protein]
deoxynivalenol results in decreased expression of GPX4 mRNA

PMID:37419272 PMID:38040082

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

gremlin 1, DAN family BMP antagonist

decreases expression

deoxynivalenol results in decreased expression of GREM1 mRNA

NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082

G

gasdermin D

increases expression
multiple interactions

deoxynivalenol results in increased expression of GSDMD mRNA; deoxynivalenol results in increased expression of GSDMD protein
deoxynivalenol promotes the reaction [fumonisin B1 results in increased expression of GSDMD mRNA]; deoxynivalenol promotes the reaction [fumonisin B1 results in increased expression of GSDMD protein]; deoxynivalenol results in increased expression of and results in increased cleavage of GSDMD protein; fumonisin B1 promotes the reaction [deoxynivalenol results in increased expression of GSDMD mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol results in increased expression of GSDMD protein]

PMID:35925383 PMID:36309173

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

gasdermin E

multiple interactions

acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [deoxynivalenol results in increased expression of and results in increased cleavage of GSDME protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased expression of and results in increased cleavage of GSDME protein]; deoxynivalenol results in increased expression of and results in increased cleavage of GSDME protein
[GSDME protein co-treated with deoxynivalenol] results in increased secretion of IL1B protein; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased cleavage of GSDME protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [deoxynivalenol results in increased cleavage of GSDME protein]; deoxynivalenol results in decreased expression of and results in increased cleavage of GSDME protein; GSDME protein inhibits the reaction [deoxynivalenol results in increased cleavage of PARP1 protein]; GSDME protein promotes the reaction [deoxynivalenol results in increased secretion of IL6 protein]

NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806

G

glycogen synthase kinase 3 beta

increases phosphorylation

deoxynivalenol results in increased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione synthetase

increases expression
multiple interactions

deoxynivalenol results in increased expression of GSS mRNA
Resveratrol inhibits the reaction [deoxynivalenol results in decreased expression of GSS protein]; Resveratrol promotes the reaction [deoxynivalenol results in increased expression of GSS protein]

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

H1.0 linker histone

increases expression

deoxynivalenol results in increased expression of H1-0 mRNA

NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694

G

H1.10 linker histone

increases expression

deoxynivalenol results in increased expression of H1-10 mRNA

NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448

G

H1.2 linker histone, cluster member

increases expression

deoxynivalenol results in increased expression of H1-2 mRNA

NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635

G

H1.5 linker histone, cluster member

decreases phosphorylation

deoxynivalenol results in decreased phosphorylation of H1F5 protein

NCBI chr17:42,726,132...42,727,162
Ensembl chr17:42,726,127...42,769,160

G

hyaluronan and proteoglycan link protein 1

decreases expression

deoxynivalenol results in decreased expression of HAPLN1 mRNA

NCBI chr 2:20,631,640...20,696,388
Ensembl chr 2:20,631,640...20,693,777

G

HAUS augmin like complex subunit 2

increases expression

deoxynivalenol results in increased expression of HAUS2 mRNA

NCBI chr 3:107,553,146...107,565,982
Ensembl chr 3:107,553,161...107,565,157

G

hemoglobin alpha, adult chain 1

increases phosphorylation

deoxynivalenol results in increased phosphorylation of HBA protein

NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392

G

hemoglobin subunit beta

affects phosphorylation

deoxynivalenol affects the phosphorylation of HBB-B1 protein

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

HCK proto-oncogene, Src family tyrosine kinase

increases phosphorylation
affects response to substance
multiple interactions

deoxynivalenol results in increased phosphorylation of HCK protein
HCK protein affects the susceptibility to deoxynivalenol
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in