glycosylglucose - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	glycosylglucose	go back to main search page
Accession:	CHEBI:24405	browse the term
Synonyms:	related_synonym:	glycosylglucoses

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Rat (221) Mouse (223) Human (224) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (221)

beta-maltose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

maltase-glucoamylase

multiple interactions
increases metabolic processing

[MGAM protein results in increased metabolism of Maltose] which results in increased abundance of Glucose

NCBI chr 4:69,441,626...69,602,068
Ensembl chr 4:69,446,150...69,692,715

G

solute carrier family 2 member 2

multiple interactions

Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 3

multiple interactions

Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]; Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Galactose]

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

crocin-1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acid phosphatase 5, tartrate resistant

multiple interactions

crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

actin alpha 2, smooth muscle

multiple interactions

crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

AKT serine/threonine kinase 2

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

autophagy related 5

multiple interactions

crocin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]]

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

BMP and activin membrane-bound inhibitor

multiple interactions

crocin inhibits the reaction [Cisplatin results in decreased expression of BAMBI mRNA]

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; crocin inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; crocin inhibits the reaction [Diazinon results in increased expression of BAX protein]; crocin inhibits the reaction [Malathion results in increased expression of BAX protein]
crocin results in increased expression of BAX mRNA
crocin inhibits the reaction [Zearalenone results in increased expression of BAX protein]

PMID:23523949 PMID:26231423 PMID:27353299 PMID:32886819 PMID:32920515 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[crocin co-treated with Paraquat] results in decreased expression of BCL2 mRNA; crocin inhibits the reaction [Zearalenone results in decreased expression of BCL2 protein]
crocin results in decreased expression of BCL2 mRNA
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]

PMID:26231423 PMID:31911963 PMID:32886819 PMID:32920515

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

increases expression

crocin results in increased expression of BDNF mRNA; crocin results in increased expression of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions

crocin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]; crocin inhibits the reaction [Blood Glucose results in increased phosphorylation of BECN1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

baculoviral IAP repeat-containing 5

decreases expression

crocin results in decreased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

multiple interactions
increases activity
increases expression
increases cleavage

crocin affects the reaction [Ethanol results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased cleavage of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased expression of CASP3 protein modified form]; crocin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; crocin inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
crocin results in increased activity of CASP3 protein
crocin results in increased expression of CASP3 mRNA
crocin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]
Acetylcysteine inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein]

PMID:23523949 PMID:25637687 PMID:25899501 PMID:26807765 PMID:27353299 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

crocin results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases activity

crocin inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
crocin results in increased activity of CASP9 protein

PMID:27353299 PMID:32886819 PMID:35274200

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity
increases activity

crocin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; crocin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; crocin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
crocin results in decreased activity of CAT protein
crocin inhibits the reaction [Patulin results in increased activity of CAT protein]; crocin inhibits the reaction [Zearalenone results in increased activity of CAT protein]
crocin results in increased activity of CAT protein

PMID:25899501 PMID:26231423 PMID:26584762 PMID:29409856 PMID:32886819 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

decreases expression

crocin results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

creatine kinase, M-type

multiple interactions

crocin inhibits the reaction [Diazinon results in increased activity of CKM protein]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

collagen type II alpha 1 chain

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

cAMP responsive element binding protein 1

multiple interactions

crocin results in increased expression of and results in increased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome c, somatic

multiple interactions

crocin inhibits the reaction [Diazinon affects the localization of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity

crocin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]
crocin results in decreased activity of CYP2E1 protein

PMID:25899501 PMID:32633567

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

forkhead box P2

increases expression

crocin results in increased expression of FOXP2 protein

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

glyoxalase 1

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

glutamic--pyruvic transaminase

multiple interactions

crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; crocin inhibits the reaction [Cisplatin results in increased activity of GPT protein]
crocin inhibits the reaction [Zearalenone results in increased expression of GPT protein]

PMID:26231423 PMID:32259551 PMID:32633567

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

heme oxygenase 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

crocin inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA]

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

interleukin 10

multiple interactions

crocin inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]

PMID:24709313 PMID:26807765

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
decreases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; crocin inhibits the reaction [Ethanol results in decreased expression of IL6 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
crocin results in decreased expression of IL6 mRNA

PMID:25637687 PMID:25899501 PMID:29409856 PMID:32633567 PMID:32886819 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

crocin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

Janus kinase 2

multiple interactions

crocin affects the expression of and affects the phosphorylation of JAK2 protein

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Kelch-like ECH-associated protein 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

low density lipoprotein receptor

multiple interactions

crocin inhibits the reaction [Diazinon results in decreased expression of LDLR mRNA]

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

[Quercetin co-treated with crocin] inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]; crocin inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK1 protein]
crocin results in decreased phosphorylation of MAPK1 protein

PMID:24132704 PMID:28689058 PMID:32886819

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK3 protein]
crocin results in decreased phosphorylation of MAPK3 protein
crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]

PMID:24132704 PMID:28689058 PMID:30580027 PMID:32886819

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microRNA 122

multiple interactions
decreases expression

crocin inhibits the reaction [bisphenol A results in increased expression of MIR122 mRNA]
crocin results in decreased expression of MIR122

PMID:28689058 PMID:36988377

NCBI chr18:58,758,703...58,758,787

G

microRNA 29b-1

increases expression
multiple interactions

crocin results in increased expression of MIR29B1 mRNA
Cisplatin inhibits the reaction [crocin results in increased expression of MIR29B1 mRNA]; crocin inhibits the reaction [Cisplatin results in decreased expression of MIR29B1 mRNA]

NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067

G

microRNA 34a

multiple interactions

MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]

NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103

G

myeloperoxidase

multiple interactions

crocin inhibits the reaction [Ethanol results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

crocin results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYCN proto-oncogene, bHLH transcription factor

decreases response to substance
multiple interactions
decreases expression

MYCN results in decreased susceptibility to crocin
crocin results in decreased expression of and results in decreased stability of MYCN mRNA; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]
crocin results in decreased expression of MYCN protein

NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590

G

MYD88, innate immune signal transduction adaptor

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 protein]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NFE2 like bZIP transcription factor 2

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; crocin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein]

PMID:32259551 PMID:32920515

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

osteoclastogenesis associated transmembrane protein 1

multiple interactions

[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]

NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

peroxisome proliferator-activated receptor gamma

multiple interactions

crocin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein kinase AMP-activated non-catalytic subunit beta 1

multiple interactions

crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased phosphorylation of PRKAB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased phosphorylation of PRKAB1 protein]]

NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661

G

prostaglandin-endoperoxide synthase 2

decreases expression

crocin results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 4

multiple interactions
increases expression

MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein]

NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]; crocin inhibits the reaction [Streptozocin results in increased expression of RELA protein]

PMID:29409856 PMID:32920515

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

SMAD family member 2

decreases expression
multiple interactions

crocin results in decreased expression of SMAD2 protein
Cisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein]; crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein]

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

synuclein alpha

multiple interactions

crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

sprouty RTK signaling antagonist 2

increases expression

crocin results in increased expression of SPRY2 protein

NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009

G

sequestosome 1

multiple interactions

crocin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

signal transducer and activator of transcription 3

multiple interactions

crocin affects the expression of and affects the phosphorylation of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 1

multiple interactions

crocin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]]

PMID:29409856 PMID:32259551 PMID:32633567 PMID:33021114

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 1

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein]

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

toll-like receptor 4

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TLR4 protein]

PMID:29409856 PMID:32259551

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
decreases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; crocin inhibits the reaction [Ethanol results in decreased expression of TNF protein]
crocin results in decreased expression of TNF mRNA

PMID:25637687 PMID:25899501 PMID:26807765 PMID:32633567 PMID:32886819 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 11

multiple interactions

[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

troponin T2, cardiac type

multiple interactions

crocin inhibits the reaction [Doxorubicin results in increased expression of TNNT2 protein]

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

G

tumor protein p53

multiple interactions

crocin inhibits the reaction [Paraquat results in increased expression of TRP53 mRNA]; crocin inhibits the reaction [Zearalenone results in increased expression of TRP53 protein]

PMID:26231423 PMID:31911963

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TNF receptor associated factor 6

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

VGF nerve growth factor inducible

increases expression

crocin results in increased expression of VGF protein

NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341

kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

high mobility group box 1

multiple interactions
decreases response to substance

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]; kaempferol 3-O-sophoroside inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]
kaempferol 3-O-sophoroside results in decreased susceptibility to HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

intercellular adhesion molecule 1

multiple interactions

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

selectin E

multiple interactions

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

toll-like receptor 2

multiple interactions

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

multiple interactions

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

vascular cell adhesion molecule 1

multiple interactions

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

lactose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

decreases activity

Lactose results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

galectin 3

affects binding

Lactose binds to LGALS3 protein

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

superoxide dismutase 1

decreases activity

Lactose results in decreased activity of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

maltose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

maltase-glucoamylase

multiple interactions
increases metabolic processing

[MGAM protein results in increased metabolism of Maltose] which results in increased abundance of Glucose

NCBI chr 4:69,441,626...69,602,068
Ensembl chr 4:69,446,150...69,692,715

G

solute carrier family 2 member 2

multiple interactions

Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]; Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 3

multiple interactions

Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Deoxyglucose]; Maltose inhibits the reaction [SLC2A3 protein results in increased transport of Galactose]

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

melibiose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BAG cochaperone 3

increases expression

Melibiose results in increased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

heat shock protein family B (small) member 8

increases expression

Melibiose results in increased expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

microtubule-associated protein 1 light chain 3 beta

increases expression

Melibiose results in increased expression of MAP1LC3B mRNA

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

sequestosome 1

increases expression

Melibiose results in increased expression of SQSTM1 mRNA

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

transcription factor EB

affects localization
multiple interactions

Melibiose affects the localization of TFEB protein
Cyclosporine inhibits the reaction [Melibiose affects the localization of TFEB protein]

NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714

G

zinc finger with KRAB and SCAN domains 3

increases expression

Melibiose results in increased expression of ZKSCAN3 mRNA

NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827

naringin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

naringin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

acetyl-CoA carboxylase alpha

multiple interactions

[naringin co-treated with Dietary Fats] results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

angiotensin I converting enzyme

multiple interactions

naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of ACE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]

PMID:32172062 PMID:32810514

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acetylcholinesterase

multiple interactions

[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of ACHE protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [[potassium bromate co-treated with Caffeine] results in increased activity of ACHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ACHE protein]; naringin inhibits the reaction [Caffeine results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; naringin inhibits the reaction [potassium bromate results in increased activity of ACHE protein]

PMID:32172062 PMID:32428650 PMID:32810514 PMID:37865952

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acyl-CoA oxidase 1

multiple interactions

naringin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acid phosphatase 5, tartrate resistant

multiple interactions
decreases expression

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [Polymethyl Methacrylate analog results in increased expression of and results in increased activity of ACP5 protein]
naringin results in decreased expression of ACP5 mRNA

PMID:21835177 PMID:24376342

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

adenosine deaminase

multiple interactions

naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein]; naringin inhibits the reaction [[potassium bromate co-treated with Caffeine] results in increased activity of ADA protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ADA protein]; naringin inhibits the reaction [Caffeine results in increased activity of ADA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ADA protein]; naringin inhibits the reaction [potassium bromate results in increased activity of ADA protein]

PMID:32172062 PMID:32428650 PMID:32810514 PMID:37865952

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

adiponectin, C1Q and collagen domain containing

multiple interactions

naringin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

angiotensinogen

multiple interactions

naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]; naringin inhibits the reaction [AGT protein results in increased secretion of Aldosterone]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aldo-keto reductase family 7, member A2

multiple interactions

naringin inhibits the reaction [Acetaminophen results in decreased expression of AKR7A5 protein]

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]
naringin inhibits the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of AKT1 mRNA]

PMID:19810018 PMID:25773745 PMID:29510123 PMID:30878453

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

angiopoietin 1

affects expression

naringin affects the expression of ANGPT1 mRNA

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

aquaporin 1

multiple interactions

naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein]

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 5

multiple interactions

naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein]

NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209

G

activating transcription factor 6

multiple interactions

naringin inhibits the reaction [Oxaliplatin results in increased expression of ATF6 mRNA]

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ATPase H+ transporting V0 subunit D2

multiple interactions

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

G

BCL2-associated agonist of cell death

multiple interactions

naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAD mRNA]
naringin inhibits the reaction [Dexamethasone results in increased phosphorylation of BAD protein]

PMID:21945202 PMID:30878453

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

naringin results in increased expression of BAX mRNA
CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of BAX protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BAX protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]
naringin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of BAX protein]; naringin inhibits the reaction [Oxaliplatin results in increased expression of BAX mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of BAX protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]

PMID:21945202 PMID:22847135 PMID:28422390 PMID:30130594 PMID:30878453 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions

naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of BCHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of BCHE protein]

PMID:32172062 PMID:32810514

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Oxaliplatin results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Oxaliplatin results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]
naringin results in decreased expression of BCL2 protein
CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Dexamethasone results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]
naringin inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]

PMID:21945202 PMID:28422390 PMID:30130594 PMID:30878453 PMID:35166444 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

increases expression
increases secretion
multiple interactions

naringin results in increased expression of BGLAP mRNA; naringin results in increased expression of BGLAP protein
naringin results in increased secretion of BGLAP protein
fulvestrant inhibits the reaction [naringin results in increased secretion of BGLAP protein]

PMID:18495116 PMID:21741227 PMID:23596885

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

bone morphogenetic protein 2

multiple interactions
decreases expression
increases secretion
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]; FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]; JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin promotes the reaction [FOS protein binds to BMP2 promoter]; naringin promotes the reaction [JUN protein binds to BMP2 promoter]
naringin results in decreased expression of BMP2 mRNA
fulvestrant inhibits the reaction [naringin results in increased secretion of BMP2 protein]
naringin results in increased expression of BMP2 mRNA; naringin results in increased expression of BMP2 protein

PMID:18495116 PMID:21820093 PMID:23596885

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 3

decreases expression

naringin results in decreased expression of BMP3 mRNA

NCBI chr14:10,712,489...10,737,153
Ensembl chr14:10,712,489...10,737,153

G

bone morphogenetic protein 4

increases expression

naringin results in increased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

calcitonin receptor

multiple interactions

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]

NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392

G

caspase 3

increases expression
multiple interactions

naringin results in increased expression of CASP3 mRNA
naringin inhibits the reaction [Acetaminophen results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein modified form]; naringin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; naringin inhibits the reaction [Dexamethasone results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of CASP3 protein]
naringin inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]; naringin inhibits the reaction [Acrylamide results in increased expression of CASP3 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; rottlerin inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]

PMID:21945202 PMID:22847135 PMID:25773745 PMID:26612654 PMID:28422390 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases expression
multiple interactions

naringin results in increased expression of CASP9 mRNA
[bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP9 protein]; naringin inhibits the reaction [bisphenol A results in increased expression of CASP9 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]

PMID:22847135 PMID:25773745 PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

naringin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; naringin inhibits the reaction [Ferric Compounds results in decreased activity of CAT protein]; naringin inhibits the reaction [Nanotubes, Carbon results in decreased activity of CAT protein]
naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of CAT protein]; naringin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CAT protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; naringin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]; naringin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]

PMID:20950607 PMID:21345335 PMID:21945202 PMID:22198281 PMID:25773745 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]
naringin inhibits the reaction [Cyclophosphamide results in increased expression of CCL2 mRNA]

PMID:22965302 PMID:33992719

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

multiple interactions

naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin D1

decreases expression
multiple interactions
increases expression

naringin results in decreased expression of CCND1 protein
naringin inhibits the reaction [Dexamethasone results in increased expression of CCND1 mRNA]
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CCND1 protein]
naringin results in increased expression of CCND1 mRNA

PMID:18296682 PMID:18951945 PMID:24915843 PMID:26482937 PMID:30878453

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

decreases expression

naringin results in decreased expression of CCNE1 protein

PMID:18296682 PMID:18951945

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin dependent kinase 2

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK2 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein

PMID:18296682 PMID:18951945

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK4 protein]

PMID:18296682 PMID:18951945

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]
naringin results in increased expression of CDKN1A mRNA; naringin results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]

PMID:18296682 PMID:18951945

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CF transmembrane conductance regulator

multiple interactions

naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

ChaC glutathione specific gamma-glutamylcyclotransferase 2

multiple interactions

CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of CHAC2 protein]

PMID:35166444 PMID:35179299

NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301

G

collagen type I alpha 1 chain

increases expression

naringin results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

carnitine palmitoyltransferase 1A

multiple interactions

[Dietary Fats co-treated with naringin] results in decreased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

colony stimulating factor 1 receptor

multiple interactions

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

catenin beta 1

increases expression
multiple interactions

naringin results in increased expression of CTNNB1 mRNA
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CTNNB1 protein]

PMID:24915843 PMID:26482937

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin B

multiple interactions

naringin inhibits the reaction [Isoproterenol results in decreased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin K

multiple interactions
decreases expression

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]
naringin results in decreased expression of CTSK mRNA

PMID:21835177 PMID:24376342

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

C-X-C motif chemokine ligand 12

increases expression

naringin results in increased expression of CXCL12 protein

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 2

affects expression

naringin affects the expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine receptor 4

increases expression

naringin results in increased expression of CXCR4 protein

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome b-245 alpha chain

multiple interactions

naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein]

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome c, somatic

multiple interactions

naringin inhibits the reaction [Cadmium Chloride results in increased expression of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

naringin inhibits the reaction [Acrylamide results in decreased expression of CYP17A1 mRNA]

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

naringin results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

naringin results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

naringin binds to and results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
multiple interactions

naringin results in decreased activity of CYP3A4 protein
naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil]

PMID:16013069 PMID:21053930

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dihydrofolate reductase

decreases activity

naringin results in decreased activity of DHFR protein

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

dickkopf WNT signaling pathway inhibitor 1

multiple interactions

DKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]]

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

epidermal growth factor

multiple interactions

naringin inhibits the reaction [EGF protein affects the localization of RELA protein]; naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]; naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

naringin inhibits the reaction [Oxaliplatin results in increased expression of EIF2AK3 mRNA]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

naringin inhibits the reaction [Oxaliplatin results in increased expression of ERN1 mRNA]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

estrogen receptor 1

multiple interactions
increases expression

fulvestrant inhibits the reaction [naringin results in increased expression of ESR1 mRNA]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
increases expression

fulvestrant inhibits the reaction [naringin results in increased expression of ESR2 mRNA]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

fatty acid binding protein 4

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

Fas associated via death domain

increases expression

naringin results in increased expression of FADD mRNA

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fas cell surface death receptor

increases expression

naringin results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

multiple interactions

naringin affects the reaction [LEPR protein affects the activity of FASN protein]; naringin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]

PMID:16427799 PMID:22198281

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibroblast growth factor 2

multiple interactions
increases expression

fulvestrant inhibits the reaction [naringin results in increased expression of FGF2 mRNA]

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin promotes the reaction [FOS protein binds to BMP2 promoter]
naringin results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

follicle stimulating hormone subunit beta

multiple interactions

naringin inhibits the reaction [Acrylamide results in decreased expression of FSHB protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of G6PC1 mRNA]; naringin inhibits the reaction [Dietary Fats results in increased expression of G6PC1 mRNA]

PMID:16427799 PMID:22198281

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

multiple interactions

naringin inhibits the reaction [nickel sulfate results in decreased activity of G6PD protein]
naringin affects the reaction [LEPR protein affects the activity of G6PD protein]

PMID:16427799 PMID:20950607

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

galanin and GMAP prepropeptide

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased activity of GAL protein]

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

glucokinase

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of GCK mRNA]

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; [naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein]; rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein]
naringin results in increased expression of GCLC mRNA; naringin results in increased expression of GCLC protein

PMID:22871521 PMID:25773745

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamic-oxaloacetic transaminase 1

multiple interactions

naringin inhibits the reaction [Acetaminophen results in increased secretion of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

naringin affects the reaction [Cyclophosphamide affects the activity of GPT protein]; naringin inhibits the reaction [Oxaliplatin results in increased activity of GPT protein]; naringin inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
naringin inhibits the reaction [Acetaminophen results in increased secretion of GPT protein]; naringin inhibits the reaction [Doxorubicin results in increased expression of GPT protein]

PMID:27174133 PMID:33992719 PMID:35166444 PMID:36811345 PMID:38037725

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

increases activity

naringin results in increased activity of GPX1 protein

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

multiple interactions

naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]; naringin inhibits the reaction [nickel sulfate results in decreased activity of GSR protein]
naringin inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein]

PMID:20950607 PMID:21945202 PMID:23650045 PMID:33992719

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase pi 1

increases expression
multiple interactions

naringin results in increased expression of GSTP1 mRNA
[naringin co-treated with 3-nitropropionic acid] results in increased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glucuronidase, beta

multiple interactions

naringin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]
naringin affects the reaction [LEPR protein affects the activity of HMGCR protein]

PMID:16427799 PMID:16906524

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

multiple interactions
increases expression
increases activity

CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; naringin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 protein]; naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]
naringin results in increased expression of HMOX1 mRNA; naringin results in increased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; [naringin co-treated with 3-nitropropionic acid] results in increased expression of HMOX1 mRNA; naringin inhibits the reaction [Oxaliplatin results in decreased expression of HMOX1 mRNA]; naringin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA]; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [naringin results in increased expression of HMOX1 protein]
naringin results in increased activity of HMOX1 protein

PMID:22871521 PMID:23603004 PMID:25773745 PMID:27174133 PMID:35166444 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HRas proto-oncogene, GTPase

multiple interactions
increases activity

HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in increased activity of HRAS protein

PMID:18296682 PMID:18951945

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heat shock protein family A (Hsp70) member 5

multiple interactions

naringin inhibits the reaction [Oxaliplatin results in increased expression of HSPA5 mRNA]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

intercellular adhesion molecule 1

multiple interactions
affects expression

naringin inhibits the reaction [Glucose results in increased expression of ICAM1]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
naringin inhibits the reaction [Acetaminophen results in increased expression of ICAM1 mRNA]
naringin affects the expression of ICAM1 mRNA

PMID:22074828 PMID:25117567 PMID:25391245 PMID:35166444 PMID:35179299

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon, alpha 1

multiple interactions

naringin inhibits the reaction [Cyclophosphamide results in increased expression of IFNA1 mRNA]

NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925

G

interferon gamma

multiple interactions
affects expression

naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]
naringin affects the expression of IFNG mRNA

PMID:16945185 PMID:21500970

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

affects expression
multiple interactions
increases expression

naringin affects the expression of IGF1 mRNA
naringin inhibits the reaction [Dexamethasone results in increased expression of IGF1 mRNA]
naringin results in increased expression of IGF1 mRNA
fulvestrant inhibits the reaction [naringin results in increased expression of IGF1 mRNA]

PMID:23596885 PMID:24880026 PMID:30878453

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 10

multiple interactions
affects expression

naringin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of IL10 protein]
naringin affects the expression of IL10 protein

PMID:22985397 PMID:25117567

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

affects expression
multiple interactions

naringin affects the expression of IL1B mRNA
[bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of IL1B protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein]; naringin inhibits the reaction [Acrylamide results in increased expression of IL1B protein]; naringin inhibits the reaction [bisphenol A results in increased expression of IL1B protein]; naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; naringin inhibits the reaction [Oxaliplatin results in increased expression of IL1B mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B protein]
naringin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; naringin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]

PMID:24131540 PMID:24880026 PMID:30130594 PMID:32172062 PMID:32428650 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

multiple interactions

naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1R1 mRNA]

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 2

affects expression

naringin affects the expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

affects expression

naringin affects the expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

affects expression
multiple interactions
decreases expression

naringin affects the expression of IL6 mRNA
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of IL6 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; naringin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
naringin results in decreased expression of IL6 protein
naringin affects the expression of IL6 protein
naringin inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 protein]

PMID:16137700 PMID:19810018 PMID:21820093 PMID:24131540 PMID:24880026 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions
affects expression

naringin inhibits the reaction [Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; naringin promotes the reaction [Glucose results in increased secretion of INS1 protein]
naringin affects the expression of INS1 protein

PMID:24880026 PMID:29658312

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin receptor substrate 1

multiple interactions

naringin inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS1 protein]

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]; naringin promotes the reaction [JUN protein binds to BMP2 promoter]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]
naringin results in increased expression of JUN mRNA

PMID:18495116 PMID:35166444

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

Kelch-like ECH-associated protein 1

multiple interactions

naringin inhibits the reaction [Doxorubicin results in decreased expression of KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

lecithin cholesterol acyltransferase

multiple interactions

naringin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

lactate dehydrogenase A

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

lactate dehydrogenase B

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

leptin

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein; naringin inhibits the reaction [Glucose results in increased expression of LEP protein]

PMID:21820093 PMID:22198281 PMID:24399619

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

multiple interactions

naringin affects the reaction [LEPR protein affects the abundance of Glucose]; naringin affects the reaction [LEPR protein affects the activity of FASN protein]; naringin affects the reaction [LEPR protein affects the activity of G6PD protein]; naringin affects the reaction [LEPR protein affects the activity of HMGCR protein]; naringin affects the reaction [LEPR protein affects the expression of G6PC1 mRNA]; naringin affects the reaction [LEPR protein affects the expression of GCK mRNA]; naringin affects the reaction [LEPR protein affects the expression of PCK1 mRNA]; naringin affects the reaction [LEPR protein affects the expression of PPARG protein]; naringin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; naringin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]
naringin inhibits the reaction [Glucose results in increased expression of LEPR protein]

PMID:16427799 PMID:24399619

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

luteinizing hormone subunit beta

multiple interactions

naringin inhibits the reaction [Acrylamide results in decreased expression of LHB protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

lipoprotein lipase

multiple interactions

naringin inhibits the reaction [Isoproterenol results in decreased activity of LPL protein]

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

monoamine oxidase A

multiple interactions

[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of MAOA protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of MAOA protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of MAOA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]

PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]
naringin results in decreased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]
naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]

PMID:18296682 PMID:18951945 PMID:21835177 PMID:22198281 PMID:22766066 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 10

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK10 protein]

NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201

G

mitogen activated protein kinase 14

multiple interactions

naringin inhibits the reaction [Acrylamide results in increased expression of MAPK14 mRNA]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in decreased phosphorylation of MAPK3 protein
naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]

PMID:18296682 PMID:18951945 PMID:21835177 PMID:22198281 PMID:22766066 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microRNA 126a

multiple interactions
increases expression

MIR126 mRNA affects the reaction [naringin results in decreased expression of VCAM1 mRNA]
naringin results in increased expression of MIR126 mRNA

NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180

G

matrix metallopeptidase 2

multiple interactions

naringin results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

naringin inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [Paraquat results in increased expression of MMP9 protein]
naringin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; naringin results in decreased expression of and results in decreased activity of MMP9 protein
naringin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; naringin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MMP9 protein]

PMID:19810018 PMID:22985397 PMID:23603004 PMID:25866363 PMID:26721195

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

naringin inhibits the reaction [Tobacco Smoke Pollution results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

metallothionein 3

multiple interactions

naringin inhibits the reaction [Cadmium Chloride results in increased expression of MT3 protein]

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

mechanistic target of rapamycin kinase

multiple interactions

naringin inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]; naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]
naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased secretion of MUC5AC protein]

PMID:22766066 PMID:31301536

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; [naringin co-treated with 3-nitropropionic acid] affects the localization of NFE2L2 protein; naringin inhibits the reaction [Oxaliplatin results in decreased expression of NFE2L2 mRNA]; naringin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [naringin affects the localization of NFE2L2 protein]
CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]

PMID:22871521 PMID:25773745 PMID:27174133 PMID:35166444 PMID:35179299 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

naringin inhibits the reaction [Cisplatin results in increased expression of NFKB1 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of NFKB1 mRNA]

PMID:26120027 PMID:26612654 PMID:38037725

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

affects degradation
multiple interactions

naringin affects the degradation of NFKBIA protein
naringin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]

PMID:21835177 PMID:25117567

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

affects expression
multiple interactions

naringin affects the expression of NOS2 mRNA
naringin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]; naringin inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of NOS2 mRNA]

PMID:16137700 PMID:22871521 PMID:25117567 PMID:26612654 PMID:38037725

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NADPH oxidase 4

multiple interactions

naringin inhibits the reaction [TNF protein results in increased expression of NOX4 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 protein]

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

[naringin co-treated with 3-nitropropionic acid] results in increased expression of NQO1 mRNA
naringin results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

oxoglutarate dehydrogenase

multiple interactions

naringin inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein]

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of PCK1 mRNA]

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

phosphodiesterase 5A

multiple interactions

naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein]; naringin inhibits the reaction [[potassium bromate co-treated with Caffeine] results in increased activity of PDE5A protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of PDE5A protein]; naringin inhibits the reaction [Caffeine results in increased activity of PDE5A protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; naringin inhibits the reaction [potassium bromate results in increased activity of PDE5A protein]

PMID:32172062 PMID:32428650 PMID:32810514 PMID:37865952

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions

naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3CA mRNA]

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA]

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

peroxisome proliferator activated receptor alpha

multiple interactions

naringin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of PPARG protein]; naringin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]

PMID:16427799 PMID:22198281 PMID:30130594

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions

naringin inhibits the reaction [Ethanol results in increased expression of PPARGC1A mRNA]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein kinase C, delta

increases phosphorylation
multiple interactions

naringin results in increased phosphorylation of PRKCD protein
rottlerin inhibits the reaction [naringin results in increased phosphorylation of PRKCD protein]

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

prostaglandin-endoperoxide synthase 2

affects expression
multiple interactions

naringin affects the expression of PTGS2 mRNA; naringin affects the expression of PTGS2 protein
naringin inhibits the reaction [Acetaminophen results in increased expression of PTGS2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of PTGS2 protein]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of PTGS2 mRNA]

PMID:16137700 PMID:22871521 PMID:25117567 PMID:35166444 PMID:35179299 More...

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions
increases activity
increases phosphorylation

RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
RAF1 protein affects the reaction [naringin results in decreased expression of CDK2 protein]; RAF1 protein affects the reaction [naringin results in decreased expression of CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in increased activity of RAF1 protein
naringin results in increased phosphorylation of RAF1 protein

PMID:18296682 PMID:18951945

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [EGF protein affects the localization of RELA protein]
naringin affects the expression of and affects the activity of RELA protein; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]

PMID:21500970 PMID:22766066 PMID:22965302 PMID:25117567

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ribosomal protein S6 kinase B1

multiple interactions

naringin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [Okadaic Acid results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]

PMID:15342961 PMID:19810018

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

RUNX family transcription factor 2

increases expression
multiple interactions

naringin results in increased expression of RUNX2 mRNA
naringin inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]
DKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]]; naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of RUNX2 mRNA]

PMID:21741227 PMID:23596885 PMID:24915843 PMID:26482937 PMID:30878453

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sirtuin 1

multiple interactions

naringin inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA]
naringin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]

PMID:18793633 PMID:36811345

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 2 member 2

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 4

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier organic anion transporter family, member 1a4

multiple interactions

naringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quinine]

PMID:24947867 PMID:25466967 PMID:27504015

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

solute carrier organic anion transporter family member 1B2

multiple interactions

naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]

PMID:21256917 PMID:22394605

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

SMAD family member 3

multiple interactions

naringin inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

superoxide dismutase 2

multiple interactions

CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; naringin inhibits the reaction [Ferric Compounds results in decreased activity of SOD2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]

PMID:21345335 PMID:35166444 PMID:35179299 PMID:36811345

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

Sp7 transcription factor

increases expression
multiple interactions

naringin results in increased expression of SP7 mRNA
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP7 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of SP7 mRNA]

PMID:23596885 PMID:26482937

NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847

G

sialophorin

multiple interactions
increases expression
decreases expression

[bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of SPN protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [bisphenol A results in increased expression of SPN protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]
naringin results in increased expression of SPN protein
naringin results in decreased expression of SPN protein

PMID:32172062 PMID:32428650

NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628

G

secreted phosphoprotein 1

increases expression
increases secretion
multiple interactions

naringin results in increased expression of SPP1 mRNA; naringin results in increased expression of SPP1 protein
naringin results in increased secretion of SPP1 protein
fulvestrant inhibits the reaction [naringin results in increased secretion of SPP1 protein]

PMID:18495116 PMID:23596885 PMID:24915843

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sterol regulatory element binding transcription factor 1

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

steroidogenic acute regulatory protein

multiple interactions

naringin inhibits the reaction [Acrylamide results in decreased expression of STAR mRNA]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 3

affects expression

naringin affects the expression of STAT3 mRNA; naringin affects the expression of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 1

multiple interactions
affects expression

naringin inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
naringin inhibits the reaction [Cyclophosphamide results in increased expression of TGFB1 mRNA]; naringin inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]
naringin affects the expression of TGFB1 mRNA

PMID:23603004 PMID:25117567 PMID:27174133 PMID:33992719

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

TIMP metallopeptidase inhibitor 1

multiple interactions

naringin inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; naringin inhibits the reaction [Paraquat results in increased expression of TIMP1 protein]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions
affects expression

naringin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; naringin inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; naringin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; naringin inhibits the reaction [Paraquat results in increased expression of TNF mRNA]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein]; naringin inhibits the reaction [Acrylamide results in increased expression of TNF protein]; naringin inhibits the reaction [bisphenol A results in increased expression of TNF protein]; naringin inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; naringin inhibits the reaction [Oxaliplatin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; naringin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; naringin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; naringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF protein]
naringin affects the expression of TNF protein
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 protein]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
naringin affects the expression of TNF mRNA

PMID:16137700 PMID:19810018 PMID:21500970 PMID:22198281 PMID:22871521 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11A

decreases expression

naringin results in decreased expression of TNFRSF11A mRNA

NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695

G

TNF receptor superfamily member 11B

multiple interactions

naringin inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of TNFRSF11B protein]

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF superfamily member 11

multiple interactions

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]; naringin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

troponin T2, cardiac type

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

G

tumor protein p53

increases expression
multiple interactions
decreases expression

naringin results in increased expression of TP53 mRNA
naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]
naringin results in decreased expression of TP53 protein
[bisphenol A co-treated with naringin] results in decreased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of TP53 protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein]; naringin inhibits the reaction [Acrylamide results in increased expression of TP53 mRNA]; naringin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of TP53 mRNA]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]

PMID:22847135 PMID:26120027 PMID:26612654 PMID:32172062 PMID:32428650 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thymic stromal lymphopoietin

multiple interactions

naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP protein]

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

uncoupling protein 2

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

vascular cell adhesion molecule 1

multiple interactions
decreases expression

MIR126 mRNA affects the reaction [naringin results in decreased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
naringin results in decreased expression of VCAM1 mRNA; naringin results in decreased expression of VCAM1 protein

PMID:24975661 PMID:25391245

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor C

affects expression

naringin affects the expression of VEGFC mRNA

NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848

neoeriocitrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone gamma-carboxyglutamate protein

multiple interactions
increases expression

neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA]
neoeriocitrin results in increased expression of BGLAP mRNA

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

collagen type I alpha 1 chain

multiple interactions
increases expression

neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of COL1A1 mRNA]
neoeriocitrin results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

RUNX family transcription factor 2

increases expression

neoeriocitrin results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

neohesperidin dihydrochalcone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

glutamic--pyruvic transaminase

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

interleukin 6

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

nitric oxide synthase 2

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

prostaglandin-endoperoxide synthase 2

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

taste 1 receptor member 2

multiple interactions

lactisole inhibits the reaction [neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]; neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]

NCBI chr 5:151,909,617...151,925,760
Ensembl chr 5:151,830,701...151,925,345

G

taste 1 receptor member 3

multiple interactions
affects binding

lactisole inhibits the reaction [neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]; neohesperidin dihydrochalcone binds to and results in increased activity of TAS1R3 protein; neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]
neohesperidin dihydrochalcone binds to TAS1R3 protein

PMID:17935609 PMID:20173092

NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742

royal jelly

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

royal jelly inhibits the reaction [Fluorides results in decreased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA]
royal jelly inhibits the reaction [Fluorides results in increased expression of BCL2 protein]

PMID:30896085 PMID:34227456

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

multiple interactions

royal jelly inhibits the reaction [Fluorides results in decreased expression of BDNF protein]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

caspase 3

multiple interactions

royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]
royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP3 protein]

PMID:30896085 PMID:34227456

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

multiple interactions

royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP6 protein]

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 9

multiple interactions

royal jelly inhibits the reaction [Fluorides results in decreased expression of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

royal jelly inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; royal jelly inhibits the reaction [Fluorides results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]

PMID:20369241 PMID:30896085 PMID:34227456

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

multiple interactions

royal jelly inhibits the reaction [phenylhydrazine affects the expression of CCND1 mRNA]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

E2F transcription factor 1

multiple interactions

royal jelly inhibits the reaction [Paclitaxel results in increased expression of E2F1 mRNA]

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

estrogen receptor 1

multiple interactions
increases activity
affects binding

Estradiol inhibits the reaction [royal jelly binds to ESR1 protein]; royal jelly binds to and results in increased activity of ESR1 protein; royal jelly inhibits the reaction [Estradiol binds to ESR1 protein]
royal jelly results in increased activity of ESR1 protein

PMID:15946813 PMID:17287592

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
affects binding

Estradiol inhibits the reaction [royal jelly binds to ESR2 protein]; royal jelly binds to and results in increased activity of ESR2 protein; royal jelly inhibits the reaction [Estradiol binds to ESR2 protein]

PMID:15946813 PMID:17287592

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

glycogen synthase kinase 3 beta

multiple interactions

royal jelly inhibits the reaction [Fluorides results in increased expression of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

insulin 1

multiple interactions

royal jelly inhibits the reaction [Fructose results in increased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
decreases expression

royal jelly inhibits the reaction [phenylhydrazine results in decreased expression of MYC mRNA]
royal jelly inhibits the reaction [Paclitaxel results in decreased expression of MYC mRNA]
royal jelly results in decreased expression of MYC mRNA

PMID:27496854 PMID:35099105

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

NFE2 like bZIP transcription factor 2

multiple interactions

royal jelly inhibits the reaction [Fluorides results in decreased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

proliferating cell nuclear antigen

multiple interactions

royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

royal jelly inhibits the reaction [Fluorides results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

trefoil factor 1

increases expression

royal jelly results in increased expression of TFF1 mRNA

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

tumor protein p53

multiple interactions

royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

vascular endothelial growth factor A

increases expression

royal jelly results in increased expression of VEGFA mRNA

PMID:15946813 PMID:17287592

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19867
chemical entity	19865
atom	19865
nonmetal atom	19787
oxygen atom	19527
oxygen molecular entity	19527
organooxygen compound	19189
carbohydrates and carbohydrate derivatives	15289
glycan	8335
oligosaccharide	628
disaccharide	533
glycosylglucose	221
2-(beta-D-glucopyranosyluronic acid)-D-glucuronic acid	0
D-alpha-D-Hepp-(1->6)-beta-D-Glcp	0
D-galactosyl-(1->4)-beta-D-glucose +	0
allolactose +	0
alpha-D-Galp-(1->2)-D-Glcp +	0
alpha-D-Galp-(1->3)-D-Glcp	0
alpha-D-Galp-(1->4)-D-Glcp +	0
alpha-D-Galp-(1->6)-alpha-D-Glcp	0
alpha-D-Glcp-(1->2)-D-Glcp +	0
alpha-D-Xylp-(1->3)-D-Glcp	0
alpha-D-Xylp-(1->3)-beta-D-Glcp	0
alpha-D-Xylp-(1->6)-D-Glcp +	0
alpha-L-Arap-(1->2)-beta-D-Glcp	0
alpha-L-Arap-(1->4)-beta-D-Glcp	0
alpha-L-Arap-(1->6)-beta-D-Glcp +	0
alpha-L-Fucp-(1->2)-D-Glcp +	0
alpha-L-Fucp-(1->3)-Glcp +	0
alpha-L-Fucp-(1->4)-alpha-D-Glcp	0
alpha-L-Fucp-(1->6)-D-Glcp +	0
alpha-L-Rhap-(1->3)-beta-D-Glcp	0
alpha-L-Rhap-(1->6)-D-Glcp	0
alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranose +	169
beta-D-Galp-(1->2)-D-Glcp +	0
beta-D-Galp-(1->3)-D-Glcp +	0
beta-D-Glcp-(1->6)-beta-D-Glcp +	0
beta-D-Manp-(1->4)-D-Glcp	0
beta-D-Xylf-(1->6)-beta-D-Glcp	0
beta-D-Xylp-(1->2)-D-Glcp	0
beta-D-Xylp-(1->3)-D-Glcp +	0
beta-D-Xylp-(1->4)-D-Glcp +	0
beta-D-Xylp-(1->6)-D-Glcp +	0
beta-D-Xylp-(1->6)-alpha-D-Glcp	0
beta-D-apiofuranosyl-(1->6)-D-glucopyranose +	0
beta-L-Fucp-(1->2)-alpha-D-Glcp	0
beta-L-Fucp-(1->2)-beta-D-Glcp	0
beta-L-Fucp-(1->3)-alpha-D-Glcp	0
beta-L-Fucp-(1->4)-alpha-D-Glcp	0
beta-L-Fucp-(1->6)-alpha-D-Glcp	0
cellobiose +	0
gentiobiose +	65
glycosylglucose derivative +	0
isomaltose +	0
kojibiose	0
lactose +	3
laminarabiose +	0
maltose +	23
melibiose +	26
nigerose +	0
primeverose	0
rutinose	0
sophorose +	6
vicianose	0
Path 2
Term	Annotations
CHEBI ontology	19867
subatomic particle	19865
composite particle	19865
hadron	19865
baryon	19865
nucleon	19865
atomic nucleus	19865
atom	19865
main group element atom	19803
p-block element atom	19803
carbon group element atom	19744
carbon atom	19740
organic molecular entity	19740
heteroorganic entity	19512
organochalcogen compound	19273
organooxygen compound	19189
carbohydrates and carbohydrate derivatives	15289
carbohydrate	15289
oligosaccharide	628
disaccharide	533
glycosylglucose	221
2-(beta-D-glucopyranosyluronic acid)-D-glucuronic acid	0
D-alpha-D-Hepp-(1->6)-beta-D-Glcp	0
D-galactosyl-(1->4)-beta-D-glucose +	0
allolactose +	0
alpha-D-Galp-(1->2)-D-Glcp +	0
alpha-D-Galp-(1->3)-D-Glcp	0
alpha-D-Galp-(1->4)-D-Glcp +	0
alpha-D-Galp-(1->6)-alpha-D-Glcp	0
alpha-D-Glcp-(1->2)-D-Glcp +	0
alpha-D-Xylp-(1->3)-D-Glcp	0
alpha-D-Xylp-(1->3)-beta-D-Glcp	0
alpha-D-Xylp-(1->6)-D-Glcp +	0
alpha-L-Arap-(1->2)-beta-D-Glcp	0
alpha-L-Arap-(1->4)-beta-D-Glcp	0
alpha-L-Arap-(1->6)-beta-D-Glcp +	0
alpha-L-Fucp-(1->2)-D-Glcp +	0
alpha-L-Fucp-(1->3)-Glcp +	0
alpha-L-Fucp-(1->4)-alpha-D-Glcp	0
alpha-L-Fucp-(1->6)-D-Glcp +	0
alpha-L-Rhap-(1->3)-beta-D-Glcp	0
alpha-L-Rhap-(1->6)-D-Glcp	0
alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranose +	169
beta-D-Galp-(1->2)-D-Glcp +	0
beta-D-Galp-(1->3)-D-Glcp +	0
beta-D-Glcp-(1->6)-beta-D-Glcp +	0
beta-D-Manp-(1->4)-D-Glcp	0
beta-D-Xylf-(1->6)-beta-D-Glcp	0
beta-D-Xylp-(1->2)-D-Glcp	0
beta-D-Xylp-(1->3)-D-Glcp +	0
beta-D-Xylp-(1->4)-D-Glcp +	0
beta-D-Xylp-(1->6)-D-Glcp +	0
beta-D-Xylp-(1->6)-alpha-D-Glcp	0
beta-D-apiofuranosyl-(1->6)-D-glucopyranose +	0
beta-L-Fucp-(1->2)-alpha-D-Glcp	0
beta-L-Fucp-(1->2)-beta-D-Glcp	0
beta-L-Fucp-(1->3)-alpha-D-Glcp	0
beta-L-Fucp-(1->4)-alpha-D-Glcp	0
beta-L-Fucp-(1->6)-alpha-D-Glcp	0
cellobiose +	0
gentiobiose +	65
glycosylglucose derivative +	0
isomaltose +	0
kojibiose	0
lactose +	3
laminarabiose +	0
maltose +	23
melibiose +	26
nigerose +	0
primeverose	0
rutinose	0
sophorose +	6
vicianose	0

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