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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:geranylgeraniol
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Accession:CHEBI:24229 term browser browse the term
Definition:A diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1.
Synonyms:related_synonym: 3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-ol
 xref: CAS:7614-21-3
 xref_mesh: MESH:C017338
 xref: Reaxys:1797446;   lincs.smallmolecule:LSM-5994;   pubmed:23304195;   pubmed:23983115;   pubmed:24006306;   pubmed:24762323
 chemrof_formula: C20H34O
 chemrof_smiles: CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCO
 chemrof_inchi: InChI=1S/C20H34O/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-21/h9,11,13,15,21H,6-8,10,12,14,16H2,1-5H3
 chemrof_inchikey: OJISWRZIEWCUBN-UHFFFAOYSA-N



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geranylgeraniol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases chemical synthesis ISO AKR1B10 protein results in increased chemical synthesis of geranylgeraniol CTD PMID:21187079 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases chemical synthesis ISO AKR1C3 protein results in increased chemical synthesis of geranylgeraniol CTD PMID:21187079 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438
JBrowse link
G Casp3 caspase 3 increases activity ISO geranylgeraniol results in increased activity of CASP3 protein CTD PMID:9175767 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO geranylgeraniol inhibits the reaction [rosiglitazone results in increased expression of CAV1 mRNA] CTD PMID:15314095 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO geranylgeraniol inhibits the reaction [Zoledronic Acid results in decreased expression of CCN1 protein] CTD PMID:19530242 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883
JBrowse link
G Egf epidermal growth factor multiple interactions ISO geranylgeraniol analog inhibits the reaction [EGF protein results in increased phosphorylation of RHOA protein] CTD PMID:24587105 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO geranylgeraniol inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]; geranylgeraniol inhibits the reaction [Simvastatin results in decreased expression of F3] CTD PMID:9081680 PMID:12753293 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases activity
ISO [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein; [MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to geranylgeraniol; MVK gene mutant form promotes the reaction [geranylgeraniol results in decreased activity of HMGCR protein] CTD PMID:12477733 PMID:19819230 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions ISO geranylgeraniol inhibits the reaction [zoledronic acid results in increased expression of IBSP mRNA] CTD PMID:15324309 NCBI chr14:5,744,497...5,757,242
Ensembl chr14:5,744,501...5,775,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO geranylgeraniol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]
geranylgeraniol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
CTD PMID:20304105 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO
EXP
geranylgeraniol inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; geranylgeraniol inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]] CTD PMID:12500026 NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO
EXP
geranylgeraniol inhibits the reaction [Atorvastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; geranylgeraniol inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]] CTD PMID:12500026 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269
JBrowse link
G Mvk mevalonate kinase multiple interactions ISO [MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to geranylgeraniol; geranylgeraniol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]; geranylgeraniol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides]; MVK gene mutant form promotes the reaction [geranylgeraniol results in decreased activity of HMGCR protein] CTD PMID:12477733 PMID:20304105 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503
JBrowse link
G Myl9 myosin light chain 9 multiple interactions ISO geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MYL9 protein] CTD PMID:24587105 NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:165,742,046...165,748,410
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]; geranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT] CTD PMID:12371961 PMID:12753293 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions EXP geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein]] CTD PMID:24449418 NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:45,369,315...45,480,157
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions EXP geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]] CTD PMID:24449418 NCBI chr 1:93,708,269...93,718,218
Ensembl chr 1:93,708,218...93,719,147
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RAC1 protein]
Geranylgeraniol inhibits the reaction [Ropivacaine decreases activity of RAC1 protein in esophageal carcinoma cells]
CTD
RGD
PMID:12933658 PMID:29777701 RGD:155230817 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of RAP1A protein modified form; geranylgeraniol inhibits the reaction [zoledronic acid results in decreased geranoylation of RAP1A protein] CTD PMID:16539721 PMID:19819230 NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO
EXP
geranylgeraniol analog inhibits the reaction [EGF protein results in increased phosphorylation of RHOA protein]; geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOA protein]; geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Simvastatin results in decreased geranoylation of and affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Zoledronic Acid results in decreased expression of and affects the localization of RHOA protein]
geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein]]
CTD PMID:9398081 PMID:12477733 PMID:12933658 PMID:15324309 PMID:24449418 More... NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302
JBrowse link
G Rhoc ras homolog family member C multiple interactions ISO geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOC protein] CTD PMID:24587105 NCBI chr 2:194,975,586...194,981,637
Ensembl chr 2:194,975,242...194,983,745
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417
JBrowse link
G Sele selectin E multiple interactions ISO geranylgeraniol inhibits the reaction [Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]] CTD PMID:16740276 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO geranylgeraniol inhibits the reaction [Simvastatin promotes the reaction [TNF protein results in increased expression of SELE protein]] CTD PMID:16740276 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          volatile oil component 1878
            geranylgeraniol 25
              (E,E,E)-geranylgeraniol 0
              (Z,Z,Z)-geranylgeraniol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      chalcogen 20489
                        oxygen atom 20437
                          oxygen molecular entity 20437
                            hydroxides 19922
                              organic hydroxy compound 19685
                                alcohol 13959
                                  prenols 492
                                    polyprenol 492
                                      geranylgeraniol 25
                                        (E,E,E)-geranylgeraniol 0
                                        (Z,Z,Z)-geranylgeraniol 0
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