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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gamma-glutamylcysteine
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Accession:CHEBI:24195 term browser browse the term


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L-gamma-glutamyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions ISO gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of AIF1 protein] CTD PMID:35714925 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of AKT1 protein] CTD PMID:34767868 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein] CTD PMID:34767868 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein] CTD PMID:34767868 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP AKT activator SC79 inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein] CTD PMID:34767868 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP AKT activator SC79 inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein]]; Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein]]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP9 protein] CTD PMID:34767868 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein] CTD PMID:34767868 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased phosphorylation of CHUK protein] CTD PMID:35714925 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CYCS protein] CTD PMID:34767868 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases chemical synthesis		 EXP Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Cysteine promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Excitatory Amino Acid Agents promotes the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine] CTD PMID:15115889 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of IL1B protein]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of IL1B protein]] CTD PMID:35714925 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions EXP gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAP2K7 protein] CTD PMID:34767868 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein] CTD PMID:34767868 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:35714925 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) promotes the reaction [RELA protein binds to NOS2 promoter]]; gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of NOS2 protein]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) promotes the reaction [RELA protein binds to NOS2 promoter]]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of NOS2 protein]] CTD PMID:35714925 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO gamma-glutamylcysteine promotes the reaction [amyloid beta-protein (1-42) results in increased expression of NR4A2 mRNA]; gamma-glutamylcysteine promotes the reaction [amyloid beta-protein (1-42) results in increased expression of NR4A2 protein]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) promotes the reaction [RELA protein binds to NOS2 promoter]]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of NOS2 protein]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of PTGS2 protein]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of IL1B protein]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of TNF protein]] CTD PMID:35714925 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP AKT activator SC79 inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]]; Anisomycin inhibits the reaction [gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]]; gamma-glutamylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein] CTD PMID:34767868 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of PTGS2 protein]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of PTGS2 protein]] CTD PMID:35714925 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) promotes the reaction [RELA protein binds to NOS2 promoter]]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) promotes the reaction [RELA protein binds to NOS2 promoter]]] CTD PMID:35714925 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of TNF protein]; NR4A2 protein affects the reaction [gamma-glutamylcysteine inhibits the reaction [amyloid beta-protein (1-42) results in increased secretion of TNF protein]] CTD PMID:35714925 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    chemical entity 19865
      atom 19865
        nonmetal atom 19787
          sulfur atom 17750
            sulfur molecular entity 17750
              organosulfur compound 17449
                gamma-glutamylcysteine 20
                  L-gamma-glutamyl-L-cysteine + 20
                  L-gamma-glutamyl-L-cysteinyl-beta-alanine 0
                  bis-gamma-glutamylcystine 0
                  gammaGluCys(IAN) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organochalcogen compound 19273
                                organooxygen compound 19189
                                  carbon oxoacid 18660
                                    carboxylic acid 18657
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17551
                                            carboxamide 17551
                                              peptide 11445
                                                oligopeptide 1350
                                                  dipeptide 413
                                                    glutamyl-L-amino acid 20
                                                      gamma-glutamylcysteine 20
                                                        L-gamma-glutamyl-L-cysteine + 20
                                                        L-gamma-glutamyl-L-cysteinyl-beta-alanine 0
                                                        bis-gamma-glutamylcystine 0
                                                        gammaGluCys(IAN) 0
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