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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fluorenes
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Accession:CHEBI:24059 term browser browse the term
Definition:An ortho-fused polycyclic arene in which the skeleton is composed of two benzene rings ortho-fused to cyclopentane.


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1-Methylfluorene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects binding EXP 1-methylfluorene binds to AHR protein CTD PMID:3024361 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
2-acetamidofluorene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas aladin WD repeat nucleoporin increases expression ISO 2-Acetylaminofluorene results in increased expression of AAAS mRNA CTD PMID:21607683 NCBI chr 7:133,464,315...133,483,961
Ensembl chr 7:133,464,315...133,483,961 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
increases expression
multiple interactions
increases activity		 ISO
EXP		 2-Acetylaminofluorene results in decreased expression of ABCB1 mRNA
2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1A mRNA
lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1A mRNA]
2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1 protein
Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 protein]
2-Acetylaminofluorene results in increased activity of ABCB1 protein
[2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA; [2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA; [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]		 CTD PMID:11170838 PMID:11960367 PMID:12387747 PMID:17303067 PMID:17669244 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression
multiple interactions		 EXP 2-Acetylaminofluorene results in increased expression of ABCB1B mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1B protein
[2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased expression of ABCB1B mRNA; lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]		 CTD PMID:11020383 PMID:11170838 PMID:12801967 PMID:17070881 PMID:22084566 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of ABCC1 mRNA CTD PMID:12801967 PMID:17669244 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 increases expression ISO 2-Acetylaminofluorene results in increased expression of ABCC10 mRNA CTD PMID:12566991 NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions		 ISO 2-Acetylaminofluorene results in increased expression of ABCC2 mRNA
2-Acetylaminofluorene results in increased expression of ABCC2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC2 protein
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA]		 CTD PMID:10691972 PMID:16381673 PMID:16426233 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO
EXP		 2-Acetylaminofluorene results in increased expression of ABCC3 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC3 protein CTD PMID:10691972 PMID:12801967 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression
increases activity
multiple interactions		 ISO
EXP		 2-Acetylaminofluorene results in increased expression of ABCG2 mRNA
2-Acetylaminofluorene results in increased activity of ABCG2 protein
2-Acetylaminofluorene results in increased expression of ABCG2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCG2 protein
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA]		 CTD PMID:12819005 PMID:16381673 PMID:17538966 PMID:17669244 PMID:27475308 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ACAA2 mRNA CTD PMID:14656948 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ACMSD mRNA CTD PMID:17070881 NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209 		JBrowse link
G Acot9 acyl-CoA thioesterase 9 increases expression EXP 2-Acetylaminofluorene results in increased expression of ACOT9 mRNA CTD PMID:21784091 NCBI chr  X:40,073,197...40,123,573
Ensembl chr  X:40,064,810...40,123,559 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of ACSL3 mRNA CTD PMID:17070881 NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627 		JBrowse link
G Aen apoptosis enhancing nuclease increases expression ISO
EXP		 2-Acetylaminofluorene results in increased expression of AEN mRNA CTD PMID:17070881 PMID:21607683 PMID:22584684 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523 		JBrowse link
G Afp alpha-fetoprotein multiple interactions
increases expression		 EXP [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of AFP protein; [2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of AFP protein
2-Acetylaminofluorene results in increased expression of AFP mRNA; 2-Acetylaminofluorene results in increased expression of AFP protein		 CTD PMID:6187438 PMID:11350689 PMID:11813887 PMID:15133858 PMID:17538966 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO 2-Acetylaminofluorene results in increased expression of AHR mRNA CTD PMID:25224404 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ak1 adenylate kinase 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of AK1 mRNA CTD PMID:17317680 NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases expression ISO 2-Acetylaminofluorene results in increased expression of AKR1B1 mRNA CTD PMID:17317680 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
increases expression		 EXP
ISO		 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AKR1B10 mRNA
2-Acetylaminofluorene results in increased expression of AKR1B10 mRNA		 CTD PMID:14656948 PMID:26198647 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP 2-Acetylaminofluorene results in increased expression of AKR7A3 mRNA CTD PMID:17070881 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; [2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA
2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein]		 CTD PMID:11960367 PMID:17303067 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions
increases expression		 EXP [2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of ALB protein
2-Acetylaminofluorene results in increased expression of ALB protein		 CTD PMID:6187438 PMID:15133858 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP 2-Acetylaminofluorene results in increased expression of ALDH1A1 mRNA; 2-Acetylaminofluorene results in increased expression of ALDH1A1 protein CTD PMID:17070881 PMID:22584684 PMID:33211169 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression EXP 2-Acetylaminofluorene results in increased expression of ALDH1A3 mRNA CTD PMID:22584684 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA] CTD PMID:17317680 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Tocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein] CTD PMID:15548946 PMID:15554553 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Anapc11 anaphase promoting complex subunit 11 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ANAPC11 mRNA CTD PMID:22584684 NCBI chr10:105,875,209...105,886,307 JBrowse link
G Anxa3 annexin A3 increases expression
multiple interactions		 ISO
EXP		 2-Acetylaminofluorene results in increased expression of ANXA3 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA]
[Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of ANXA3 mRNA		 CTD PMID:17317680 PMID:18071240 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617 		JBrowse link
G Anxa8 annexin A8 increases expression ISO 2-Acetylaminofluorene results in increased expression of ANXA8 mRNA CTD PMID:17317680 NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043 		JBrowse link
G Aox1 aldehyde oxidase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of AOX1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AOX1 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770 		JBrowse link
G Apoa2 apolipoprotein A2 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of APOA2 mRNA CTD PMID:17070881 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of APOA4 mRNA CTD PMID:17070881 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of APOC3 mRNA CTD PMID:17070881 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Apod apolipoprotein D decreases expression ISO 2-Acetylaminofluorene results in decreased expression of APOD mRNA CTD PMID:20713471 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305 		JBrowse link
G Aqp5 aquaporin 5 increases expression EXP 2-Acetylaminofluorene results in increased expression of AQP5 mRNA CTD PMID:17187413 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209 		JBrowse link
G Areg amphiregulin increases expression
multiple interactions		 ISO 2-Acetylaminofluorene results in increased expression of AREG mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA]		 CTD PMID:17317680 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Asgr1 asialoglycoprotein receptor 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ASGR1 mRNA CTD PMID:17187413 NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631 		JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP 2-Acetylaminofluorene results in increased expression of ATP6V1D mRNA CTD PMID:17070881 NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA]
2-Acetylaminofluorene results in increased expression of BAX mRNA
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]		 CTD PMID:11915028 PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein]
2-Acetylaminofluorene results in increased expression of BCL2 mRNA		 CTD PMID:11915028 PMID:19167416 PMID:22213190 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression		 EXP
ISO		 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein]
2-Acetylaminofluorene results in increased expression of BCL2L1 mRNA		 CTD PMID:11915028 PMID:21607683 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression EXP 2-Acetylaminofluorene results in increased expression of BIRC5 mRNA CTD PMID:19167416 PMID:22213190 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression EXP 2-Acetylaminofluorene results in increased expression of BRCA1 mRNA CTD PMID:19167416 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP
ISO		 2-Acetylaminofluorene results in increased expression of BTG2 mRNA CTD PMID:17070881 PMID:21607683 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of BZW1 mRNA CTD PMID:17317680 NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430 		JBrowse link
G C4bpa complement component 4 binding protein, alpha decreases expression EXP 2-Acetylaminofluorene results in decreased expression of C4BPA mRNA CTD PMID:16510358 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205 		JBrowse link
G C6 complement C6 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of C6 mRNA CTD PMID:22584684 NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C7 complement C7 increases expression EXP 2-Acetylaminofluorene results in increased expression of C7 mRNA CTD PMID:17070881 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of CACNA2D1 mRNA CTD PMID:17187413 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Cadm1 cell adhesion molecule 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of CADM1 protein CTD PMID:17326163 NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CAR2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAR2 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 EXP 2-Acetylaminofluorene inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased cleavage of CASP3 protein]; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP3 protein] CTD PMID:12907702 PMID:23665045 PMID:26364502 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions		 EXP 2-Acetylaminofluorene results in increased activity of CASP9 protein
2-Acetylaminofluorene results in increased expression of CASP9 protein
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP9 protein]		 CTD PMID:23665045 PMID:26364502 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
decreases activity
decreases expression		 EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of CAT protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of CAT protein] CTD PMID:17761372 PMID:23665045 PMID:26364502 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cavin3 caveolae associated protein 3 multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAVIN3 mRNA CTD PMID:14656948 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161 		JBrowse link
G Cblc Cbl proto-oncogene C increases expression EXP 2-Acetylaminofluorene results in increased expression of CBLC mRNA CTD PMID:17070881 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Cbr1 carbonyl reductase 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of CBR1 mRNA CTD PMID:21607683 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cck cholecystokinin decreases expression EXP 2-Acetylaminofluorene results in decreased expression of CCK mRNA CTD PMID:22584684 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 affects expression EXP 2-Acetylaminofluorene affects the expression of CCL2 mRNA; 2-Acetylaminofluorene affects the expression of CCL2 protein CTD PMID:25051504 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP 2-Acetylaminofluorene results in increased expression of CCL7 protein CTD PMID:25051504 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions		 EXP 2-Acetylaminofluorene results in increased expression of CCN2 mRNA; 2-Acetylaminofluorene results in increased expression of CCN2 protein
Iloprost inhibits the reaction [2-Acetylaminofluorene results in increased expression of CCN2 mRNA]		 CTD PMID:15940639 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of CCNA2 protein CTD PMID:15158336 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression		 EXP 2-Acetylaminofluorene results in decreased expression of CCNB1 protein
2-Acetylaminofluorene results in increased expression of CCNB1 mRNA		 CTD PMID:15158336 PMID:22584684 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnb2 cyclin B2 increases expression
multiple interactions		 ISO
EXP		 2-Acetylaminofluorene results in increased expression of CCNB2 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA]		 CTD PMID:17317680 PMID:19167416 PMID:22584684 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA]
2-Acetylaminofluorene results in increased expression of CCND1 mRNA		 CTD PMID:14633663 PMID:22584684 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 multiple interactions
decreases activity		 EXP 2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA]
2-Acetylaminofluorene results in decreased activity of CCNE1 protein		 CTD PMID:10708481 PMID:14633663 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccng1 cyclin G1 decreases expression
increases expression		 EXP
ISO		 2-Acetylaminofluorene results in decreased expression of CCNG1 mRNA
2-Acetylaminofluorene results in increased expression of CCNG1 mRNA		 CTD PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cd276 Cd276 molecule increases expression EXP 2-Acetylaminofluorene results in increased expression of CD276 mRNA CTD PMID:17070881 PMID:21784091 NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380 		JBrowse link
G Cd44 CD44 molecule increases expression EXP
IEP		 2-Acetylaminofluorene results in increased expression of CD44 mRNA; 2-Acetylaminofluorene results in increased expression of CD44 protein
2-Fluorenylacetamide increases CD44 mRNA in liver, and protein in liver and serum		 CTD
RGD		 PMID:17187413 PMID:22584684 PMID:33211169 PMID:31966914 RGD:25823185 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 protein CTD PMID:16317707 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809 		JBrowse link
G Cdca3 cell division cycle associated 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDCA3 mRNA CTD PMID:22584684 NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799 		JBrowse link
G Cdh13 cadherin 13 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDH13 mRNA CTD PMID:21784091 NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459 		JBrowse link
G Cdh22 cadherin 22 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDH22 mRNA CTD PMID:17187413 NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588 		JBrowse link
G Cdh3 cadherin 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDH3 mRNA CTD PMID:17187413 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDK1 mRNA CTD PMID:19167416 PMID:22584684 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases activity		 EXP 2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; 2-Acetylaminofluorene results in decreased localization of and results in decreased phosphorylation of and results in decreased activity of CDK2 protein
2-Acetylaminofluorene results in decreased activity of CDK2 protein		 CTD PMID:10708481 PMID:15158336 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases activity EXP 2-Acetylaminofluorene results in increased activity of CDK4 protein CTD PMID:15158336 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 EXP
ISO		 2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of CDKN1A protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; pioglitazone inhibits the reaction [2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]]
2-Acetylaminofluorene results in increased expression of CDKN1A mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CDKN1A mRNA]
2-Acetylaminofluorene results in increased expression of CDKN1A mRNA; 2-Acetylaminofluorene results in increased expression of CDKN1A protein		 CTD PMID:10708481 PMID:11003613 PMID:14633663 PMID:17070881 PMID:17317680 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP 2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]; Pioglitazone inhibits the reaction [2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]] CTD PMID:17582756 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression
increases methylation		 EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A protein
2-Acetylaminofluorene results in increased expression of CDKN2A mRNA
2-Acetylaminofluorene results in increased methylation of CDKN2A gene; 2-Acetylaminofluorene results in increased methylation of CDKN2A promoter		 CTD PMID:16317707 PMID:18204080 PMID:19167416 PMID:20188851 PMID:22213190 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO
EXP		 2-Acetylaminofluorene results in increased expression of CDKN2B mRNA CTD PMID:17317680 PMID:22213190 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C increases expression EXP 2-Acetylaminofluorene results in increased expression of CDKN2C mRNA CTD PMID:22584684 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of CDKN3 mRNA CTD PMID:22213190 PMID:22584684 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP 2-Acetylaminofluorene results in decreased expression of CEBPA protein CTD PMID:20188851 PMID:21785164 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases expression		 EXP 2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter]
2-Acetylaminofluorene results in decreased expression of CEBPB protein		 CTD PMID:21785164 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Ces2e carboxylesterase 2E increases expression ISO 2-Acetylaminofluorene results in increased expression of CES2E mRNA CTD PMID:21607683 NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856 		JBrowse link
G Ces3a carboxylesterase 3a increases expression ISO 2-Acetylaminofluorene results in increased expression of CES3 mRNA CTD PMID:20713471 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of CKMT1 mRNA CTD PMID:17317680 NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758 		JBrowse link
G Cldn4 claudin 4 increases expression EXP 2-Acetylaminofluorene results in increased expression of CLDN4 mRNA CTD PMID:17187413 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Cldn7 claudin 7 increases expression EXP 2-Acetylaminofluorene results in increased expression of CLDN7 mRNA CTD PMID:17187413 NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171 		JBrowse link
G Clu clusterin multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CLU mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CLU mRNA CTD PMID:14656948 PMID:16158176 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cmas cytidine monophosphate N-acetylneuraminic acid synthetase increases expression EXP 2-Acetylaminofluorene results in increased expression of CMAS protein CTD PMID:6331524 NCBI chr 4:175,718,808...175,737,128
Ensembl chr 4:175,718,808...175,737,125 		JBrowse link
G Col17a1 collagen type XVII alpha 1 chain multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of COL17A1 mRNA] CTD PMID:17317680 NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632 		JBrowse link
G Commd3 COMM domain containing 3 increases expression ISO 2-Acetylaminofluorene results in increased expression of COMMD3 mRNA CTD PMID:17317680 NCBI chr17:81,327,444...81,331,191
Ensembl chr17:81,327,405...81,331,177 		JBrowse link
G Coq6 coenzyme Q6 monooxygenase multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of COQ6 mRNA CTD PMID:16158176 NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657 		JBrowse link
G Cpq carboxypeptidase Q decreases expression EXP 2-Acetylaminofluorene results in decreased expression of CPQ mRNA CTD PMID:17070881 NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of CPS1 protein CTD PMID:11813887 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033 		JBrowse link
G Crebbp CREB binding protein decreases expression EXP 2-Acetylaminofluorene results in decreased expression of CREBBP mRNA CTD PMID:22213190 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Cryab crystallin, alpha B increases expression EXP 2-Acetylaminofluorene results in increased expression of CRYAB mRNA CTD PMID:17070881 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Cryl1 crystallin, lambda 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CRYL1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CRYL1 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997 		JBrowse link
G Csta cystatin A affects expression ISO 2-Acetylaminofluorene affects the expression of CSTA mRNA CTD PMID:27825931 NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of CX3CL1 mRNA CTD PMID:17187413 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 affects expression EXP 2-Acetylaminofluorene affects the expression of CXCL1 protein CTD PMID:25051504 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 affects expression EXP 2-Acetylaminofluorene affects the expression of CXCL10 protein CTD PMID:25051504 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
increases expression		 EXP [2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCL12 protein
2-Acetylaminofluorene results in increased expression of CXCL12 mRNA; 2-Acetylaminofluorene results in increased expression of CXCL12 protein		 CTD PMID:12626097 PMID:15579440 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 affects expression EXP 2-Acetylaminofluorene affects the expression of CXCL2 protein CTD PMID:25051504 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression
multiple interactions		 EXP 2-Acetylaminofluorene results in increased expression of CXCR4 mRNA
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCR4 protein		 CTD PMID:12626097 PMID:15579440 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases hydrolysis
multiple interactions
increases expression		 ISO
EXP		 CYP1A1 results in increased hydrolysis of 2-Acetylaminofluorene
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA]
2-Acetylaminofluorene analog results in increased expression of CYP1A1 protein; 2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP1A1 protein		 CTD PMID:2334931 PMID:10445401 PMID:11888708 PMID:15916741 PMID:20713471 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases expression
decreases expression
multiple interactions
increases hydrolysis
increases activity		 ISO
EXP		 CYP1A2 protein affects the metabolism of 2-Acetylaminofluorene
2-Acetylaminofluorene results in increased expression of CYP1A2 protein
2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA
2-Acetylaminofluorene analog results in decreased expression of CYP1A2 protein; 2-Acetylaminofluorene results in decreased expression of CYP1A2 protein
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA]
CYP1A2 results in increased hydrolysis of 2-Acetylaminofluorene
CYP1A2 protein results in increased activity of 2-Acetylaminofluorene		 CTD PMID:2334931 PMID:2655891 PMID:15450435 PMID:15916741 PMID:16381673 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
multiple interactions		 ISO 2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA]		 CTD PMID:17317680 PMID:20713471 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of CYP2A22 mRNA CTD PMID:21607683 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases expression
increases expression		 EXP 2-Acetylaminofluorene analog results in decreased expression of CYP2B1 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B1 protein
2-Acetylaminofluorene results in increased expression of CYP2B1 protein		 CTD PMID:10445401 PMID:15916741 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 decreases expression EXP 2-Acetylaminofluorene analog results in decreased expression of CYP2B2 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B2 protein CTD PMID:15916741 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 increases expression EXP 2-Acetylaminofluorene results in increased expression of CYP2C13 mRNA CTD PMID:17070881 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression		 EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CYP2E1 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein]
2-Acetylaminofluorene analog results in increased expression of CYP2E1 protein; 2-Acetylaminofluorene results in increased expression of CYP2E1 protein		 CTD PMID:14656948 PMID:15916741 PMID:16158176 PMID:17393424 PMID:23665045 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of CYP3A2 protein CTD PMID:10445401 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
multiple interactions		 EXP 2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 protein
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP3A23-3A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP3A23-3A1 mRNA; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]; Trabectedin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]		 CTD PMID:12504080 PMID:14656948 PMID:16158176 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 increases expression EXP 2-Acetylaminofluorene results in increased expression of CYP4F5 mRNA CTD PMID:17070881 NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dap death-associated protein multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of DAP mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of DAP mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of DDAH1 mRNA CTD PMID:17070881 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339 		JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression ISO 2-Acetylaminofluorene results in increased expression of DDIT4L mRNA CTD PMID:21607683 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of DDR1 mRNA CTD PMID:17187413 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Des desmin increases expression EXP 2-Acetylaminofluorene results in increased expression of DES mRNA CTD PMID:17187413 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Dhodh dihydroorotate dehydrogenase decreases activity EXP 2-Acetylaminofluorene results in decreased activity of DHODH protein CTD PMID:6331524 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of DLK1 mRNA; 2-Acetylaminofluorene results in increased expression of DLK1 protein CTD PMID:15567716 PMID:17187413 PMID:17538966 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of DMP1 mRNA CTD PMID:17317680 NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression
increases expression		 EXP 2-Acetylaminofluorene results in decreased expression of E2F1 protein
2-Acetylaminofluorene results in increased expression of E2F1 mRNA		 CTD PMID:15158336 PMID:19167416 PMID:22213190 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f3 E2F transcription factor 3 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of E2F3 protein CTD PMID:15158336 PMID:19167416 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253 		JBrowse link
G E2f4 E2F transcription factor 4 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of E2F4 protein CTD PMID:15158336 NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806 		JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO 2-Acetylaminofluorene results in increased expression of EDA2R mRNA CTD PMID:21607683 NCBI chr  X:62,224,763...62,269,333
Ensembl chr  X:62,228,229...62,269,268 		JBrowse link
G Egf epidermal growth factor decreases localization
multiple interactions		 EXP 2-Acetylaminofluorene results in decreased localization of EGF protein
2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein]		 CTD PMID:10900465 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression		 EXP 2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein]
2-Acetylaminofluorene results in decreased expression of EGFR mRNA		 CTD PMID:10900465 PMID:22213190 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of EGR1 mRNA CTD PMID:19167416 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA] CTD PMID:17317680 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571 		JBrowse link
G Emp2 epithelial membrane protein 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of EMP2 mRNA CTD PMID:21607683 NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733 		JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of ENC1 mRNA CTD PMID:21607683 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713 		JBrowse link
G Eno1 enolase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of ENO1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ENO1 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336 		JBrowse link
G Epcam epithelial cell adhesion molecule increases expression EXP 2-Acetylaminofluorene results in increased expression of EPCAM mRNA CTD PMID:17070881 PMID:17187413 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Epha1 Eph receptor A1 increases expression ISO 2-Acetylaminofluorene results in increased expression of EPHA1 mRNA CTD PMID:17317680 NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP
ISO		 2-Acetylaminofluorene results in increased expression of EPHX1 mRNA CTD PMID:17070881 PMID:17317680 PMID:21607683 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of ERBB2 protein CTD PMID:11350689 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ESR1 mRNA CTD PMID:19167416 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Exoc4 exocyst complex component 4 increases expression ISO 2-Acetylaminofluorene results in increased expression of EXOC4 mRNA CTD PMID:21607683 NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723 		JBrowse link
G Fam110a family with sequence similarity 110, member A increases expression ISO 2-Acetylaminofluorene results in increased expression of FAM110A mRNA CTD PMID:21607683 NCBI chr 3:140,474,484...140,485,074
Ensembl chr 3:140,474,249...140,485,093 		JBrowse link
G Fas Fas cell surface death receptor increases expression EXP 2-Acetylaminofluorene results in increased expression of FAS mRNA CTD PMID:17070881 PMID:22584684 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fbxw9 F-box and WD repeat domain containing 9 increases expression ISO 2-Acetylaminofluorene results in increased expression of FBXW9 mRNA CTD PMID:21607683 NCBI chr19:23,090,534...23,097,439
Ensembl chr19:23,090,534...23,097,439 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression EXP 2-Acetylaminofluorene results in decreased expression of FHIT mRNA CTD PMID:17070881 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 affects expression EXP 2-Acetylaminofluorene affects the expression of FLT3 mRNA CTD PMID:18031378 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Fn1 fibronectin 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of FN1 mRNA CTD PMID:15940639 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein] CTD PMID:17696247 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of FTH1 protein CTD PMID:21785164 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein] CTD PMID:15554553 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gaa alpha glucosidase increases expression ISO 2-Acetylaminofluorene results in increased expression of GAA mRNA CTD PMID:17317680 NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836 		JBrowse link
G Gas2l3 growth arrest-specific 2 like 3 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of GAS2L3 mRNA CTD PMID:20713471 NCBI chr 7:23,803,578...23,836,816
Ensembl chr 7:23,806,310...23,836,411 		JBrowse link
G Gcgr glucagon receptor multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCGR mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCGR mRNA CTD PMID:14656948 PMID:16158176 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO
EXP		 2-Acetylaminofluorene results in increased expression of GCLC mRNA
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA		 CTD PMID:14656948 PMID:16158176 PMID:16426233 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLM mRNA CTD PMID:16158176 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO 2-Acetylaminofluorene results in increased expression of GDF15 mRNA CTD PMID:21607683 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression
multiple interactions		 EXP 2-Acetylaminofluorene results in increased expression of GGT1 mRNA
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]		 CTD PMID:15554553 PMID:17187413 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of GJA1 mRNA; 2-Acetylaminofluorene results in increased expression of GJA1 protein CTD PMID:15133858 PMID:17187413 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of GJB1 mRNA CTD PMID:2559087 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of GJB2 mRNA CTD PMID:22213190 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177 		JBrowse link
G Glrx3 glutaredoxin 3 increases expression ISO 2-Acetylaminofluorene results in increased expression of GLRX3 mRNA CTD PMID:17317680 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010 		JBrowse link
G Gpc3 glypican 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of GPC3 mRNA CTD PMID:17187413 NCBI chr  X:131,868,986...132,236,824
Ensembl chr  X:131,868,990...132,236,798 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GPX2 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP
ISO		 2-Acetylaminofluorene results in increased expression of GRIA3 mRNA CTD PMID:17070881 PMID:21607683 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of GRINA mRNA CTD PMID:21607683 NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
decreases expression		 EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSR mRNA; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of GSR protein] CTD PMID:16158176 PMID:23665045 PMID:26364502 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gss glutathione synthetase increases expression ISO 2-Acetylaminofluorene results in increased expression of GSS mRNA CTD PMID:17317680 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTA2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTA2 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of GSTM1 mRNA CTD PMID:17070881 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression		 EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein]
2-Acetylaminofluorene results in increased expression of GSTP1 mRNA; 2-Acetylaminofluorene results in increased expression of GSTP1 protein		 CTD PMID:12497209 PMID:12781041 PMID:12907702 PMID:15554553 PMID:17393424 More... NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gtse1 G-2 and S-phase expressed 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of GTSE1 mRNA CTD PMID:21607683 NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806 		JBrowse link
G H2ax H2A.X variant histone increases expression
increases phosphorylation		 EXP
ISO		 2-Acetylaminofluorene results in increased expression of H2AX protein
2-Acetylaminofluorene results in increased phosphorylation of H2AX protein		 CTD PMID:26338220 PMID:34510228 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of HADHA mRNA CTD PMID:16158176 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression		 EXP 2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter]
2-Acetylaminofluorene results in decreased expression of HAMP mRNA		 CTD PMID:21785164 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hebp2 heme binding protein 2 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of HEBP2 mRNA] CTD PMID:17317680 NCBI chr 1:13,194,982...13,201,777
Ensembl chr 1:13,194,982...13,201,777 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA; beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA] CTD PMID:20435455 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of HMOX1 mRNA CTD PMID:22584684 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression EXP 2-Acetylaminofluorene results in increased expression of HRAS protein CTD PMID:11350689 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of HSD17B6 mRNA CTD PMID:17070881 NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425 		JBrowse link
G Ica1 islet cell autoantigen 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of ICA1 mRNA CTD PMID:21784091 NCBI chr 4:36,656,475...36,804,705
Ensembl chr 4:36,656,475...36,804,298 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of ID1 mRNA CTD PMID:15120964 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Ifna1 interferon, alpha 1 multiple interactions EXP IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA] CTD PMID:14633663 NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Ifna2 interferon alpha 2 multiple interactions EXP IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein] CTD PMID:11915028 PMID:15368444 NCBI chr 5:103,258,617...103,259,195 JBrowse link
G Ifng interferon gamma multiple interactions EXP 2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein] CTD PMID:14736494 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of IGF2 mRNA CTD PMID:22213190 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression ISO 2-Acetylaminofluorene results in decreased expression of IGFALS mRNA CTD PMID:21607683 NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases activity ISO 2-Acetylaminofluorene results in increased activity of IKBKB protein CTD PMID:11960367 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 affects expression EXP 2-Acetylaminofluorene affects the expression of IL10 protein CTD PMID:25051504 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B increases expression EXP 2-Acetylaminofluorene results in increased expression of IL12B protein CTD PMID:25051504 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects expression
increases expression		 ISO
EXP		 2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
2-Acetylaminofluorene affects the expression of IL1B mRNA
2-Acetylaminofluorene results in increased expression of IL1B protein		 CTD PMID:14670622 PMID:25051504 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression EXP 2-Acetylaminofluorene results in increased expression of IL2RA mRNA CTD PMID:17070881 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il33 interleukin 33 increases expression ISO 2-Acetylaminofluorene results in increased expression of IL33 mRNA CTD PMID:17317680 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il5 interleukin 5 increases expression EXP 2-Acetylaminofluorene results in increased expression of IL5 protein CTD PMID:25051504 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of IL6 protein CTD PMID:25051504 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb4 integrin subunit beta 4 increases expression ISO 2-Acetylaminofluorene results in increased expression of ITGB4 mRNA CTD PMID:17317680 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein] CTD PMID:17696247 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdm6a lysine demethylase 6A decreases expression EXP 2-Acetylaminofluorene results in decreased expression of KDM6A mRNA CTD PMID:22213190 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Kif11 kinesin family member 11 increases expression EXP 2-Acetylaminofluorene results in increased expression of KIF11 mRNA CTD PMID:22584684 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression EXP 2-Acetylaminofluorene results in increased expression of KIT protein CTD PMID:15133858 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Krt14 keratin 14 increases expression EXP 2-Acetylaminofluorene results in increased expression of KRT14 protein CTD PMID:33211169 NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt15 keratin 15 increases expression
multiple interactions		 ISO 2-Acetylaminofluorene results in increased expression of KRT15 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT15 mRNA]		 CTD PMID:17317680 NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt19 keratin 19 increases expression
multiple interactions		 EXP 2-Acetylaminofluorene results in increased expression of KRT19 mRNA; 2-Acetylaminofluorene results in increased expression of KRT19 protein
[Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of KRT19 protein		 CTD PMID:15133858 PMID:17187413 PMID:17661067 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt20 keratin 20 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of KRT20 mRNA CTD PMID:17317680 NCBI chr10:84,384,790...84,394,125
Ensembl chr10:84,384,802...84,394,107 		JBrowse link
G Krt23 keratin 23 multiple interactions
increases expression		 ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT23 mRNA] CTD PMID:17317680 NCBI chr10:84,434,445...84,450,773
Ensembl chr10:84,434,380...84,450,983 		JBrowse link
G Krt4 keratin 4 increases expression
multiple interactions		 ISO 2-Acetylaminofluorene results in increased expression of KRT4 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA]		 CTD PMID:17317680 NCBI chr 7:133,046,067...133,052,027
Ensembl chr 7:133,046,515...133,052,019 		JBrowse link
G Krt8 keratin 8 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of KRT8 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of KRT8 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728 		JBrowse link
G Lep leptin increases expression EXP 2-Acetylaminofluorene results in increased expression of LEP protein CTD PMID:25051504 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lig4 DNA ligase 4 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of LIG4 mRNA CTD PMID:19167416 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Ly6d lymphocyte antigen 6 family member D increases expression ISO 2-Acetylaminofluorene results in increased expression of LY6D mRNA CTD PMID:17317680 NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733 		JBrowse link
G Ly6e lymphocyte antigen 6 family member E increases expression ISO 2-Acetylaminofluorene results in increased expression of LY6E mRNA CTD PMID:21607683 NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689 		JBrowse link
G Lypd3 Ly6/Plaur domain containing 3 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of LYPD3 mRNA] CTD PMID:17317680 NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901 		JBrowse link
G Lzic leucine zipper and CTNNBIP1 domain containing increases expression ISO 2-Acetylaminofluorene results in increased expression of LZIC mRNA CTD PMID:21607683 NCBI chr 5:159,928,260...159,941,512
Ensembl chr 5:159,920,439...159,939,685 		JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO 2-Acetylaminofluorene results in increased expression of MAL mRNA CTD PMID:17317680 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP 2-Acetylaminofluorene affects the phosphorylation of and affects the activity of MAPK8 protein CTD PMID:17546627 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mat1a methionine adenosyltransferase 1A affects acetylation
decreases expression
affects methylation		 EXP 2-Acetylaminofluorene affects the acetylation of MAT1A exon; 2-Acetylaminofluorene affects the acetylation of MAT1A promoter
2-Acetylaminofluorene results in decreased expression of MAT1A mRNA
2-Acetylaminofluorene affects the methylation of MAT1A exon; 2-Acetylaminofluorene affects the methylation of MAT1A promoter		 CTD PMID:22213190 NCBI chr16:16,983,084...17,001,284
Ensembl chr16:16,983,022...17,001,274 		JBrowse link
G Matn2 matrilin 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of MATN2 mRNA; 2-Acetylaminofluorene results in increased expression of MATN2 protein CTD PMID:17513098 NCBI chr 7:65,494,996...65,644,613
Ensembl chr 7:65,494,834...65,645,113 		JBrowse link
G Mbl2 mannose binding lectin 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of MBL2 mRNA CTD PMID:21607683 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
increases expression		 EXP
ISO		 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein
2-Acetylaminofluorene results in increased expression of MDM2 mRNA; 2-Acetylaminofluorene results in increased expression of MDM2 protein		 CTD PMID:11003613 PMID:19167416 PMID:21607683 PMID:22213190 PMID:22584684 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Meg3 maternally expressed 3 decreases expression
multiple interactions		 ISO 2-Acetylaminofluorene results in decreased expression of MEG3 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA]		 CTD PMID:17317680 NCBI chr 6:128,491,808...128,524,010 JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression
decreases expression		 EXP 2-Acetylaminofluorene results in increased expression of MGMT mRNA
2-Acetylaminofluorene results in decreased expression of MGMT mRNA		 CTD PMID:17070881 PMID:22213190 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MGST2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MGST2 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mir106b microRNA 106b increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR106B mRNA CTD PMID:19167416 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425 		JBrowse link
G Mir125b1 microRNA 125b-1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR125B-1 mRNA CTD PMID:19167416 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052 		JBrowse link
G Mir130b microRNA 130b increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR130B mRNA CTD PMID:19167416 NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244 		JBrowse link
G Mir132 microRNA 132 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR132 mRNA CTD PMID:19167416 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796 		JBrowse link
G Mir146b microRNA 146b increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR146B mRNA CTD PMID:19167416 NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525 		JBrowse link
G Mir155 microRNA 155 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR155 mRNA CTD PMID:19167416 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir17 microRNA 17 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR17; 2-Acetylaminofluorene results in increased expression of MIR17 mRNA CTD PMID:19167416 PMID:20188851 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir181b2 microRNA 181b-2 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR181B-2 mRNA CTD PMID:19167416 NCBI chr 3:22,616,948...22,617,035
Ensembl chr 3:22,616,948...22,617,035 		JBrowse link
G Mir181c microRNA 181c decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR181C mRNA CTD PMID:19167416 NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628 		JBrowse link
G Mir185 microRNA 185 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR185 mRNA CTD PMID:19167416 NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795 		JBrowse link
G Mir18a microRNA 18a increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR18A; 2-Acetylaminofluorene results in increased expression of MIR18A mRNA CTD PMID:19167416 PMID:20188851 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860 		JBrowse link
G Mir200a microRNA 200a increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR200A mRNA CTD PMID:19167416 PMID:22584684 NCBI chr 5:166,648,494...166,648,582 JBrowse link
G Mir200b microRNA 200b increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR200B mRNA CTD PMID:19167416 PMID:22584684 NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366 		JBrowse link
G Mir200c microRNA 200c increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR200C mRNA CTD PMID:19167416 NCBI chr 4:157,523,679...157,523,747 JBrowse link
G Mir202 microRNA 202 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR202 mRNA CTD PMID:19167416 NCBI chr 1:194,754,730...194,754,801
Ensembl chr 1:194,754,730...194,754,801 		JBrowse link
G Mir204 microRNA 204 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR204 mRNA CTD PMID:19167416 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040 		JBrowse link
G Mir205 microRNA 205 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR205 mRNA CTD PMID:19167416 NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985 		JBrowse link
G Mir20a microRNA 20a increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR20A; 2-Acetylaminofluorene results in increased expression of MIR20A mRNA CTD PMID:19167416 PMID:20188851 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir21 microRNA 21 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR21 mRNA CTD PMID:19167416 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir214 microRNA 214 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR214 mRNA CTD PMID:19167416 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G Mir22 microRNA 22 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR22 mRNA CTD PMID:22213190 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133 		JBrowse link
G Mir221 microRNA 221 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR221 mRNA CTD PMID:19167416 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir293 microRNA 293 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR293 mRNA CTD PMID:19167416 NCBI chr 1:65,963,050...65,963,121
Ensembl chr 1:65,963,050...65,963,121 		JBrowse link
G Mir31 microRNA 31 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR31; 2-Acetylaminofluorene results in increased expression of MIR31 mRNA CTD PMID:19167416 PMID:20188851 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Mir34a microRNA 34a increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR34A mRNA CTD PMID:19167416 PMID:22584684 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Mir3545 microRNA 3545 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR203 mRNA CTD PMID:22584684 NCBI chr 6:131,199,542...131,199,656
Ensembl chr 6:131,199,542...131,199,656 		JBrowse link
G Mir382 microRNA 382 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR382 mRNA CTD PMID:19167416 NCBI chr 6:128,748,539...128,748,618 JBrowse link
G Mir410 microRNA 410 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR410 mRNA CTD PMID:19167416 NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434 		JBrowse link
G Mir429 microRNA 429 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR429 mRNA CTD PMID:19167416 PMID:22584684 NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543 		JBrowse link
G Mir490 microRNA 490 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR490 mRNA CTD PMID:19167416 NCBI chr 4:65,047,548...65,047,631
Ensembl chr 4:65,047,548...65,047,631 		JBrowse link
G Mir93 microRNA 93 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR93; 2-Acetylaminofluorene results in increased expression of MIR93 mRNA CTD PMID:19167416 PMID:20188851 NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221 		JBrowse link
G Mir96 microRNA 96 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIR96 mRNA CTD PMID:19167416 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Mir99a microRNA 99a decreases expression EXP 2-Acetylaminofluorene results in decreased expression of MIR99A mRNA CTD PMID:19167416 PMID:22584684 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523 		JBrowse link
G Mirlet7b microRNA let-7b increases expression EXP 2-Acetylaminofluorene results in increased expression of MIRLET7B mRNA CTD PMID:19167416 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270 		JBrowse link
G Mirlet7c1 microRNA let-7c-1 increases expression EXP 2-Acetylaminofluorene results in increased expression of MIRLET7C-1 mRNA CTD PMID:19167416 NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265 		JBrowse link
G Mirlet7i microRNA let-7i increases expression EXP 2-Acetylaminofluorene results in increased expression of MIRLET7I mRNA CTD PMID:19167416 NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
increases expression		 EXP
ISO		 [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]
2-Acetylaminofluorene results in increased expression of MKI67 mRNA		 CTD PMID:15565650 PMID:17317680 PMID:17393424 PMID:23665045 PMID:26338220 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of MMP2 mRNA CTD PMID:18678246 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression EXP 2-Acetylaminofluorene results in increased expression of MMP9 mRNA CTD PMID:18678246 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt1 metallothionein 1 multiple interactions
increases expression		 EXP Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MT1A protein] CTD PMID:15565650 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase decreases expression
decreases methylation		 EXP 2-Acetylaminofluorene results in decreased expression of MTHFR mRNA
2-Acetylaminofluorene results in decreased methylation of MTHFR promoter		 CTD PMID:22213190 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Muc1 mucin 1, cell surface associated increases expression EXP 2-Acetylaminofluorene results in increased expression of MUC1 mRNA CTD PMID:17187413 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of MYBL1 mRNA CTD PMID:21607683 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases mutagenesis
increases expression		 EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein]
2-Acetylaminofluorene results in increased mutagenesis of MYC gene
2-Acetylaminofluorene results in increased expression of MYC protein		 CTD PMID:11350689 PMID:17696247 PMID:19167416 PMID:20188851 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression EXP 2-Acetylaminofluorene results in decreased expression of NAMPT mRNA CTD PMID:22584684 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nat1 N-acetyltransferase 1 increases activity ISO NAT1 protein results in increased activity of 2-Acetylaminofluorene CTD PMID:15450435 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nat2 N-acetyltransferase 2 increases activity ISO NAT2 protein results in increased activity of 2-Acetylaminofluorene CTD PMID:15450435 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nek6 NIMA-related kinase 6 increases expression EXP 2-Acetylaminofluorene results in increased expression of NEK6 mRNA CTD PMID:22584684 NCBI chr 3:22,284,269...22,356,302
Ensembl chr 3:22,284,279...22,395,990 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
increases activity		 ISO 2-Acetylaminofluorene results in increased expression of NFE2L2 mRNA
2-Acetylaminofluorene results in increased activity of NFE2L2 protein		 CTD PMID:21607683 PMID:30114225 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases localization		 ISO [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]
2-Acetylaminofluorene results in increased localization of NFKB1 protein
Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of NFKB1 protein]		 CTD PMID:11960367 PMID:17303067 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein; Acetylcysteine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein]; S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] CTD PMID:18404532 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions
increases degradation		 EXP [2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased degradation of NFKBIB protein
2-Acetylaminofluorene results in increased degradation of NFKBIB protein		 CTD PMID:11020383 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO 2-Acetylaminofluorene results in increased expression of TNFRSF10B mRNA CTD PMID:21607683 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Ninj1 ninjurin 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of NINJ1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NINJ1 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of NOS2 protein] CTD PMID:23665045 PMID:26364502 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions		 ISO 2-Acetylaminofluorene results in increased expression of NOS3 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of NOS3 mRNA]		 CTD PMID:17317680 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch1 notch receptor 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of NOTCH1 mRNA CTD PMID:21607683 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nprl2 NPR2-like, GATOR1 complex subunit increases expression ISO 2-Acetylaminofluorene results in increased expression of NPRL2 mRNA CTD PMID:17317680 NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO
EXP		 2-Acetylaminofluorene results in increased expression of NQO1 mRNA CTD PMID:21607683 PMID:22213190 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
multiple interactions		 ISO
EXP		 2-Acetylaminofluorene results in increased expression of NR1I2 mRNA
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A11 mRNA]		 CTD PMID:12504080 PMID:16381673 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nudcd2 NudC domain containing 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of NUDCD2 mRNA CTD PMID:21607683 NCBI chr10:25,163,247...25,168,738
Ensembl chr10:25,163,220...25,168,738 		JBrowse link
G Nudt7 nudix hydrolase 7 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of NUDT7 mRNA CTD PMID:21607683 NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081 		JBrowse link
G Nup50-ps1 nucleoporin 50, pseudogene 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of SPG7 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of SPG7 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 4:128,787,567...128,789,296
Ensembl chr 4:128,787,100...128,789,312 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression EXP 2-Acetylaminofluorene results in decreased expression of NUPR1 mRNA CTD PMID:17070881 PMID:22584684 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of NUSAP1 mRNA CTD PMID:22584684 NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624 		JBrowse link
G Ociad2 OCIA domain containing 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of OCIAD2 mRNA CTD PMID:17317680 NCBI chr14:34,873,668...34,889,276
Ensembl chr14:34,873,820...34,889,265 		JBrowse link
G Olfm1 olfactomedin 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of OLFM1 mRNA CTD PMID:20713471 NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239 		JBrowse link
G Osm oncostatin M increases expression EXP 2-Acetylaminofluorene results in increased expression of OSM mRNA CTD PMID:15743783 PMID:18678246 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Osmr oncostatin M receptor increases expression EXP 2-Acetylaminofluorene results in increased expression of OSMR mRNA CTD PMID:15743783 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262 		JBrowse link
G Padi2 peptidyl arginine deiminase 2 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA] CTD PMID:17317680 NCBI chr 5:153,209,053...153,251,632
Ensembl chr 5:153,209,053...153,251,632 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of PCK1 mRNA CTD PMID:16510358 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression		 EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein] CTD PMID:16352317 PMID:17393424 PMID:19167416 PMID:23665045 PMID:26364502 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PDIA3 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PDIA3 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of PECAM1 mRNA CTD PMID:17187413 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA] CTD PMID:17317680 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO
EXP		 2-Acetylaminofluorene results in increased expression of PHLDA3 mRNA CTD PMID:17070881 PMID:21607683 PMID:22584684 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of PHYH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of PHYH mRNA CTD PMID:14656948 PMID:16158176 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis EXP 2-Acetylaminofluorene results in increased mutagenesis of PIGA CTD PMID:22923490 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804 		JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting decreases expression EXP 2-Acetylaminofluorene results in decreased expression of PKD1 mRNA CTD PMID:22584684 NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128 		JBrowse link
G Pkm pyruvate kinase M1/2 increases expression EXP 2-Acetylaminofluorene results in increased expression of PKM mRNA; 2-Acetylaminofluorene results in increased expression of PKM protein CTD PMID:17538966 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pkp1 plakophilin 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of PKP1 mRNA CTD PMID:17317680 NCBI chr13:47,309,607...47,357,432
Ensembl chr13:47,309,614...47,357,465 		JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of PLK2 mRNA CTD PMID:21607683 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions		 ISO
EXP		 2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA]		 CTD PMID:17317680 PMID:19167416 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Polk DNA polymerase kappa increases expression ISO 2-Acetylaminofluorene results in increased expression of POLK mRNA CTD PMID:21607683 NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313 		JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP 2-Acetylaminofluorene results in increased expression of POR mRNA CTD PMID:15089088 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of PRC1 mRNA CTD PMID:19167416 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765 		JBrowse link
G Prkch protein kinase C, eta multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PRKCH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PRKCH mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654 		JBrowse link
G Prom1 prominin 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of PROM1 mRNA CTD PMID:17187413 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Prox1 prospero homeobox 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of PROX1 mRNA CTD PMID:22213190 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183 		JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 increases expression
multiple interactions		 EXP 2-Acetylaminofluorene results in increased expression of PSMD10 protein
RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein]		 CTD PMID:16448463 NCBI chr  X:104,656,809...104,665,122
Ensembl chr  X:104,656,812...104,665,097 		JBrowse link
G Psrc1 proline and serine rich coiled-coil 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of PSRC1 mRNA CTD PMID:21607683 NCBI chr 2:196,022,361...196,026,874
Ensembl chr 2:196,022,361...196,026,874 		JBrowse link
G Pten phosphatase and tensin homolog decreases expression EXP 2-Acetylaminofluorene results in decreased expression of PTEN protein CTD PMID:19167416 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PTGR1 mRNA CTD PMID:16158176 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PTGS2 protein] CTD PMID:23665045 PMID:26364502 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptn pleiotrophin increases expression EXP 2-Acetylaminofluorene results in increased expression of PTN mRNA CTD PMID:12057922 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Ptp4a3 protein tyrosine phosphatase 4A3 increases expression ISO 2-Acetylaminofluorene results in increased expression of PTP4A3 mRNA CTD PMID:17317680 NCBI chr 7:105,650,640...105,660,921
Ensembl chr 7:105,628,029...105,660,919 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C increases expression EXP 2-Acetylaminofluorene results in increased expression of PTPRC mRNA CTD PMID:17187413 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression EXP 2-Acetylaminofluorene results in increased expression of PTTG1 mRNA CTD PMID:19167416 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837 		JBrowse link
G Pvt1 Pvt1 oncogene increases expression ISO 2-Acetylaminofluorene results in increased expression of PVT1 mRNA CTD PMID:21607683 NCBI chr 7:93,656,528...93,879,938 JBrowse link
G Rac1 Rac family small GTPase 1 increases activity
multiple interactions		 ISO 2-Acetylaminofluorene results in increased activity of RAC1 protein
[2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA		 CTD PMID:11960367 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rassf1 Ras association domain family member 1 increases methylation EXP 2-Acetylaminofluorene results in increased methylation of RASSF1 promoter CTD PMID:20188851 NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation
multiple interactions		 EXP 2-Acetylaminofluorene affects the phosphorylation of RB1 protein
2-Acetylaminofluorene results in increased expression of and results in increased phosphorylation of RB1 protein; RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein]		 CTD PMID:15158336 PMID:16448463 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbx1 ring-box 1 increases expression ISO 2-Acetylaminofluorene results in increased expression of RBX1 mRNA CTD PMID:17317680 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
increases expression
multiple interactions
increases localization		 ISO
EXP		 2-Acetylaminofluorene results in increased activity of RELA protein
2-Acetylaminofluorene results in increased expression of RELA protein
geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of RELA protein]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]
2-Acetylaminofluorene results in increased localization of RELA protein
[RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]
2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of RELA protein]		 CTD PMID:11020383 PMID:11960367 PMID:14670622 PMID:17303067 PMID:26364502 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rgn regucalcin multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of RGN mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of RGN mRNA CTD PMID:14656948 PMID:16158176 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of RGS2 mRNA CTD PMID:22584684 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of RHBDF2 mRNA CTD PMID:21607683 NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283 		JBrowse link
G Rhob ras homolog family member B increases expression EXP 2-Acetylaminofluorene results in increased expression of RHOB mRNA CTD PMID:22584684 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 increases expression EXP 2-Acetylaminofluorene results in increased expression of RHOBTB2 mRNA CTD PMID:17070881 NCBI chr15:44,868,251...44,888,436
Ensembl chr15:44,870,376...44,888,651 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of RIPK1 mRNA CTD PMID:22584684 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression ISO 2-Acetylaminofluorene results in increased expression of RIPK3 mRNA CTD PMID:17317680 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Ripk4 receptor-interacting serine-threonine kinase 4 increases expression ISO 2-Acetylaminofluorene results in increased expression of RIPK4 mRNA CTD PMID:21607683 NCBI chr11:37,122,555...37,144,799
Ensembl chr11:37,122,565...37,144,799 		JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase increases expression EXP 2-Acetylaminofluorene results in increased expression of ROS1 mRNA CTD PMID:17187413 NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865 		JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of RPLP0 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of RPLP0 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632 		JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog multiple interactions
increases expression
decreases expression		 ISO
EXP		 TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA]
2-Acetylaminofluorene results in increased expression of RPRM mRNA
2-Acetylaminofluorene results in decreased expression of RPRM mRNA		 CTD PMID:17317680 PMID:19167416 PMID:22584684 NCBI chr 3:38,539,581...38,540,998
Ensembl chr 3:38,539,581...38,540,998 		JBrowse link
G Rps27l ribosomal protein S27-like increases expression ISO 2-Acetylaminofluorene results in increased expression of RPS27L mRNA CTD PMID:17317680 NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418
Ensembl chr12:67,562,483...67,567,418
Ensembl chr 2:67,562,483...67,567,418 		JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 increases expression ISO 2-Acetylaminofluorene results in increased expression of RRM1 mRNA CTD PMID:17317680 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO 2-Acetylaminofluorene results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of RSAD2 mRNA CTD PMID:20713471 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699 		JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression ISO 2-Acetylaminofluorene results in increased expression of S100A11 mRNA CTD PMID:17317680 NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044 		JBrowse link
G S100a14 S100 calcium binding protein A14 increases expression ISO 2-Acetylaminofluorene results in increased expression of S100A14 mRNA CTD PMID:17317680 NCBI chr 2:176,008,395...176,010,423
Ensembl chr 2:176,008,395...176,010,423 		JBrowse link
G Scarb2 scavenger receptor class B, member 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of SCARB2 mRNA CTD PMID:17317680 NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813 		JBrowse link
G Scpep1 serine carboxypeptidase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of SCPEP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of SCPEP1 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr10:73,703,275...73,732,892
Ensembl chr10:73,703,278...73,732,850 		JBrowse link
G Sctr secretin receptor increases expression EXP 2-Acetylaminofluorene results in increased expression of SCTR mRNA CTD PMID:17187413 NCBI chr13:31,127,781...31,190,162
Ensembl chr13:31,127,858...31,180,189 		JBrowse link
G Serpina7 serpin family A member 7 increases expression EXP 2-Acetylaminofluorene results in increased expression of SERPINA7 mRNA CTD PMID:17070881 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040 		JBrowse link
G Serpinb5 serpin family B member 5 increases expression
multiple interactions		 ISO 2-Acetylaminofluorene results in increased expression of SERPINB5 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA]		 CTD PMID:17317680 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756 		JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of SERPINF1 mRNA CTD PMID:21607683 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Sesn2 sestrin 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of SESN2 mRNA CTD PMID:21607683 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Sfn stratifin increases expression EXP 2-Acetylaminofluorene results in increased expression of SFN mRNA CTD PMID:19167416 PMID:22213190 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sirt1 sirtuin 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of SIRT1 protein CTD PMID:19167416 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc15a5 solute carrier family 15, member 5 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of SLC15A5 mRNA CTD PMID:21607683 NCBI chr 4:170,878,021...170,971,620
Ensembl chr 4:170,878,021...170,971,620 		JBrowse link
G Slc16a10 solute carrier family 16 member 10 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of SLC16A10 mRNA CTD PMID:17070881 NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of SLC25A4 mRNA] CTD PMID:17317680 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Slc2a8 solute carrier family 2 member 8 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SLC2A8 mRNA] CTD PMID:17317680 NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of SLC40A1 mRNA CTD PMID:21785164 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1A4 mRNA CTD PMID:16158176 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1B2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SLCO1B2 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein] CTD PMID:15368444 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein] CTD PMID:15368444 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad4 SMAD family member 4 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of SMAD4 mRNA CTD PMID:22213190 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smo smoothened, frizzled class receptor increases expression EXP 2-Acetylaminofluorene results in increased expression of SMO mRNA CTD PMID:17187413 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Sncg synuclein, gamma increases expression EXP 2-Acetylaminofluorene results in increased expression of SNCG mRNA CTD PMID:22213190 NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368 		JBrowse link
G Sntg2 syntrophin, gamma 2 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of SNTG2 mRNA CTD PMID:21607683 NCBI chr 6:46,801,893...47,003,390
Ensembl chr 6:46,801,377...47,003,372 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of SOCS1 mRNA CTD PMID:22213190 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of SOD1 protein CTD PMID:17761372 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein; O-(Chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein] CTD PMID:17761372 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sox4 SRY-box transcription factor 4 increases expression EXP 2-Acetylaminofluorene results in increased expression of SOX4 mRNA CTD PMID:22584684 NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of SPINK1 mRNA CTD PMID:17070881 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Sprr1a small proline-rich protein 1A increases expression ISO 2-Acetylaminofluorene results in increased expression of SPRR1A mRNA CTD PMID:17317680 NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063 		JBrowse link
G Sprr2f small proline rich protein 2F increases expression
multiple interactions		 ISO 2-Acetylaminofluorene results in increased expression of SPRR2F mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SPRR2F mRNA]		 CTD PMID:17317680 NCBI chr 2:177,989,974...177,990,204
Ensembl chr 2:177,989,974...177,990,204 		JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 increases expression ISO 2-Acetylaminofluorene results in increased expression of SPTLC2 mRNA CTD PMID:17317680 NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542 		JBrowse link
G Sst somatostatin increases expression EXP 2-Acetylaminofluorene results in increased expression of SST protein CTD PMID:16534498 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173 		JBrowse link
G St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 decreases expression ISO 2-Acetylaminofluorene results in decreased expression of ST3GAL3 mRNA CTD PMID:21607683 NCBI chr 5:131,470,348...131,670,794
Ensembl chr 5:131,470,348...131,670,810 		JBrowse link
G St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 increases expression EXP 2-Acetylaminofluorene results in increased expression of ST3GAL5 protein CTD PMID:6331524 NCBI chr 4:104,134,613...104,192,558
Ensembl chr 4:104,134,613...104,192,558 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein; Dexamethasone inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein] CTD PMID:12957465 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Steap3 STEAP3 metalloreductase decreases expression EXP 2-Acetylaminofluorene results in decreased expression of STEAP3 mRNA CTD PMID:22584684 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519 		JBrowse link
G Stmn1 stathmin 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of STMN1 mRNA CTD PMID:22584684 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase decreases expression EXP 2-Acetylaminofluorene results in decreased expression of SUGCT mRNA CTD PMID:17070881 NCBI chr17:47,376,392...48,234,362
Ensembl chr17:47,376,521...48,234,376 		JBrowse link
G Sulf2 sulfatase 2 increases expression EXP
ISO		 2-Acetylaminofluorene results in increased expression of SULF2 mRNA CTD PMID:17070881 PMID:21607683 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415 		JBrowse link
G Sult1c2a sulfotransferase family 1C member 2A decreases expression ISO 2-Acetylaminofluorene results in decreased expression of SULT1C2 mRNA CTD PMID:21607683 NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SULT1E1 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of SULT2A1 mRNA CTD PMID:17070881 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Taldo1 transaldolase 1 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TALDO1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TALDO1 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974 		JBrowse link
G Tceal9 transcription elongation factor A like 9 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TCEAL9 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TCEAL9 mRNA CTD PMID:14656948 PMID:16158176 NCBI chr  X:99,245,645...99,247,720
Ensembl chr  X:99,228,458...99,247,763 		JBrowse link
G Tes testin LIM domain protein increases expression EXP 2-Acetylaminofluorene results in increased expression of TES mRNA CTD PMID:21784091 NCBI chr 4:45,365,304...45,403,829
Ensembl chr 4:45,365,285...45,403,829 		JBrowse link
G Tf transferrin decreases expression EXP 2-Acetylaminofluorene results in decreased expression of TF mRNA CTD PMID:16510358 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TFF1 mRNA] CTD PMID:17317680 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tff3 trefoil factor 3 increases expression EXP 2-Acetylaminofluorene results in increased expression of TFF3 mRNA CTD PMID:22213190 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054 		JBrowse link
G Tfrc transferrin receptor increases expression EXP 2-Acetylaminofluorene results in increased expression of TFRC mRNA CTD PMID:21785164 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein]
2-Acetylaminofluorene results in increased expression of TGFB1 mRNA		 CTD PMID:15368444 PMID:15940639 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thrb thyroid hormone receptor beta increases activity ISO 2-Acetylaminofluorene results in increased activity of THRB protein CTD PMID:31077750 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Thy1 Thy-1 cell surface antigen increases expression EXP 2-Acetylaminofluorene results in increased expression of THY1 protein CTD PMID:17576600 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP 2-Acetylaminofluorene results in increased expression of TIMP1 mRNA CTD PMID:18678246 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tkt transketolase multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TKT mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TKT mRNA CTD PMID:14656948 PMID:16158176 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698 		JBrowse link
G Tmem134 transmembrane protein 134 increases expression ISO 2-Acetylaminofluorene results in increased expression of TMEM134 mRNA CTD PMID:17317680 NCBI chr 1:201,419,225...201,424,778
Ensembl chr 1:201,419,264...201,431,411 		JBrowse link
G Tmem184c transmembrane protein 184C increases expression EXP 2-Acetylaminofluorene results in increased expression of TMEM184C mRNA CTD PMID:21784091 NCBI chr19:30,345,183...30,361,275
Ensembl chr19:30,345,290...30,361,269 		JBrowse link
G Tmem43 transmembrane protein 43 increases expression ISO 2-Acetylaminofluorene results in increased expression of TMEM43 mRNA CTD PMID:21607683 NCBI chr 4:123,977,680...123,992,823
Ensembl chr 4:123,977,625...123,992,825 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TNF protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein] CTD PMID:18271918 PMID:23665045 PMID:25051504 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Top2a DNA topoisomerase II alpha increases expression EXP 2-Acetylaminofluorene results in increased expression of TOP2A mRNA CTD PMID:22584684 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression
increases response to substance
multiple interactions		 EXP
ISO		 2-Acetylaminofluorene results in increased expression of TP53 protein
2-Acetylaminofluorene results in increased expression of TRP53 protein
2-Acetylaminofluorene results in decreased expression of TP53 protein
TRP53 protein modified form results in increased susceptibility to 2-Acetylaminofluorene
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CDKN1A mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of ZMAT3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of CYP4F15 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of SLC25A4 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of TTR mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of COL17A1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of HEBP2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT15 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT23 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of LYPD3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of NOS3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SLC2A8 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SPRR2F mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TFF1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TSHB mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TUBA1C mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of UBE2C mRNA]
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of TP53 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; Vanadium promotes the reaction [2-Acetylaminofluorene results in increased expression of TP53 protein]		 CTD PMID:7728945 PMID:9667752 PMID:10708481 PMID:11003613 PMID:11915028 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions
increases expression		 EXP
ISO		 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of TRP53INP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of TRP53INP1 mRNA
2-Acetylaminofluorene results in increased expression of TP53INP1 mRNA
2-Acetylaminofluorene results in increased expression of TRP53INP1 mRNA		 CTD PMID:14656948 PMID:16158176 PMID:21607683 PMID:22584684 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968 		JBrowse link
G Tp73 tumor protein p73 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of TP73 mRNA CTD PMID:22213190 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions EXP [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TRPM2 mRNA CTD PMID:16158176 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of TSC22D1 mRNA CTD PMID:15089088 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TSHB mRNA] CTD PMID:17317680 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
G Ttr transthyretin multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of TTR mRNA] CTD PMID:17317680 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Tuba1c tubulin, alpha 1C multiple interactions ISO TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TUBA1C mRNA] CTD PMID:17317680 NCBI chr 7:130,192,050...130,199,655
Ensembl chr 7:130,192,016...130,199,647
Ensembl chr  X:130,192,016...130,199,647 		JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression ISO
EXP		 2-Acetylaminofluorene results in increased expression of TUBB4B mRNA CTD PMID:21607683 PMID:22584684 NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296 		JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression EXP 2-Acetylaminofluorene results in increased expression of TUBB5 mRNA CTD PMID:22584684 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression ISO 2-Acetylaminofluorene results in increased expression of TUBB6 mRNA CTD PMID:21607683 NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C increases expression
multiple interactions		 ISO
EXP		 2-Acetylaminofluorene results in increased expression of UBE2C mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of UBE2C mRNA]		 CTD PMID:17317680 PMID:22584684 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2-Acetylaminofluorene analog CTD PMID:11375903 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO
EXP		 2-Acetylaminofluorene results in increased expression of VCAM1 mRNA
2-Acetylaminofluorene results in increased expression of VCAM1 protein		 CTD PMID:21607683 PMID:25051504 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
increases expression		 EXP 2-Acetylaminofluorene results in decreased expression of VEGFA mRNA
geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of VEGFA protein]		 CTD PMID:22213190 PMID:25051504 PMID:26364502 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression EXP 2-Acetylaminofluorene results in increased expression of WEE1 mRNA CTD PMID:22584684 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688 		JBrowse link
G Wwox WW domain-containing oxidoreductase decreases expression ISO 2-Acetylaminofluorene results in decreased expression of WWOX mRNA CTD PMID:21607683 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391 		JBrowse link
G Xdh xanthine dehydrogenase increases activity
multiple interactions		 EXP 2-Acetylaminofluorene results in increased activity of XDH protein
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]		 CTD PMID:23665045 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor decreases response to substance ISO XPC protein results in decreased susceptibility to 2-Acetylaminofluorene CTD PMID:23153559 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ZEB1 protein CTD PMID:19167416 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 decreases expression EXP 2-Acetylaminofluorene results in decreased expression of ZEB2 protein CTD PMID:19167416 NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
G Zmat3 zinc finger, matrin type 3 multiple interactions
increases expression		 ISO
EXP		 TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of ZMAT3 mRNA]
2-Acetylaminofluorene results in increased expression of ZMAT3 mRNA		 CTD PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684 NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863 		JBrowse link
4-acetylaminofluorene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression EXP 4-acetylaminofluorene results in increased expression of ABCB1B mRNA CTD PMID:17070881 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase increases expression EXP 4-acetylaminofluorene results in increased expression of ACMSD mRNA CTD PMID:17070881 NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression EXP 4-acetylaminofluorene results in increased expression of ACSL3 mRNA CTD PMID:17070881 NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627 		JBrowse link
G Aen apoptosis enhancing nuclease decreases expression EXP 4-acetylaminofluorene results in decreased expression of AEN mRNA CTD PMID:17070881 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP 4-acetylaminofluorene results in increased expression of AKR7A3 mRNA CTD PMID:17070881 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP 4-acetylaminofluorene results in increased expression of ALDH1A1 mRNA CTD PMID:17070881 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Apoa2 apolipoprotein A2 decreases expression EXP 4-acetylaminofluorene results in decreased expression of APOA2 mRNA CTD PMID:17070881 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apoa4 apolipoprotein A4 decreases expression EXP 4-acetylaminofluorene results in decreased expression of APOA4 mRNA CTD PMID:17070881 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP 4-acetylaminofluorene results in decreased expression of APOC3 mRNA CTD PMID:17070881 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP 4-acetylaminofluorene results in increased expression of ATP6V1D mRNA CTD PMID:17070881 NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP 4-acetylaminofluorene results in increased expression of BAX mRNA CTD PMID:17070881 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression EXP 4-acetylaminofluorene results in decreased expression of BTG2 mRNA CTD PMID:17070881 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G C7 complement C7 decreases expression EXP 4-acetylaminofluorene results in decreased expression of C7 mRNA CTD PMID:17070881 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535 		JBrowse link
G Cblc Cbl proto-oncogene C increases expression EXP 4-acetylaminofluorene results in increased expression of CBLC mRNA CTD PMID:17070881 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP 4-acetylaminofluorene results in increased expression of CCNG1 mRNA CTD PMID:17070881 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cd276 Cd276 molecule increases expression EXP 4-acetylaminofluorene results in increased expression of CD276 mRNA CTD PMID:17070881 NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression EXP 4-acetylaminofluorene results in decreased expression of CDKN1A mRNA CTD PMID:17070881 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cpq carboxypeptidase Q decreases expression EXP 4-acetylaminofluorene results in decreased expression of CPQ mRNA CTD PMID:17070881 NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546 		JBrowse link
G Cryab crystallin, alpha B decreases expression EXP 4-acetylaminofluorene results in decreased expression of CRYAB mRNA CTD PMID:17070881 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 decreases expression EXP 4-acetylaminofluorene results in decreased expression of CYP2C13 mRNA CTD PMID:17070881 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191 		JBrowse link
G Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 increases expression EXP 4-acetylaminofluorene results in increased expression of CYP4F5 mRNA CTD PMID:17070881 NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 decreases expression EXP 4-acetylaminofluorene results in decreased expression of DDAH1 mRNA CTD PMID:17070881 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339 		JBrowse link
G Epcam epithelial cell adhesion molecule increases expression EXP 4-acetylaminofluorene results in increased expression of EPCAM mRNA CTD PMID:17070881 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP 4-acetylaminofluorene results in increased expression of EPHX1 mRNA CTD PMID:17070881 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Fas Fas cell surface death receptor increases expression
decreases expression		 EXP 4-acetylaminofluorene results in increased expression of FAS mRNA
4-acetylaminofluorene results in decreased expression of FAS mRNA		 CTD PMID:17070881 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression EXP 4-acetylaminofluorene results in decreased expression of FHIT mRNA CTD PMID:17070881 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP 4-acetylaminofluorene results in decreased expression of GRIA3 mRNA CTD PMID:17070881 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP 4-acetylaminofluorene results in increased expression of GSTM1 mRNA CTD PMID:17070881 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 increases expression EXP 4-acetylaminofluorene results in increased expression of HSD17B6 mRNA CTD PMID:17070881 NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha increases expression EXP 4-acetylaminofluorene results in increased expression of IL2RA mRNA CTD PMID:17070881 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 4-acetylaminofluorene results in increased expression of MGMT mRNA CTD PMID:17070881 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP 4-acetylaminofluorene results in increased expression of NUPR1 mRNA CTD PMID:17070881 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 decreases expression EXP 4-acetylaminofluorene results in decreased expression of PHLDA3 mRNA CTD PMID:17070881 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP 4-acetylaminofluorene results in increased expression of POR mRNA CTD PMID:15089088 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 increases expression EXP 4-acetylaminofluorene results in increased expression of RHOBTB2 mRNA CTD PMID:17070881 NCBI chr15:44,868,251...44,888,436
Ensembl chr15:44,870,376...44,888,651 		JBrowse link
G Serpina7 serpin family A member 7 decreases expression EXP 4-acetylaminofluorene results in decreased expression of SERPINA7 mRNA CTD PMID:17070881 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040 		JBrowse link
G Slc16a10 solute carrier family 16 member 10 increases expression EXP 4-acetylaminofluorene results in increased expression of SLC16A10 mRNA CTD PMID:17070881 NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP 4-acetylaminofluorene results in increased expression of SPINK1 mRNA CTD PMID:17070881 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase increases expression EXP 4-acetylaminofluorene results in increased expression of SUGCT mRNA CTD PMID:17070881 NCBI chr17:47,376,392...48,234,362
Ensembl chr17:47,376,521...48,234,376 		JBrowse link
G Sulf2 sulfatase 2 decreases expression EXP 4-acetylaminofluorene results in decreased expression of SULF2 mRNA CTD PMID:17070881 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP 4-acetylaminofluorene results in increased expression of SULT2A1 mRNA CTD PMID:17070881 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression EXP 4-acetylaminofluorene results in decreased expression of TSC22D1 mRNA CTD PMID:15089088 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958 		JBrowse link
G Zmat3 zinc finger, matrin type 3 decreases expression EXP 4-acetylaminofluorene results in decreased expression of ZMAT3 mRNA CTD PMID:17070881 NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863 		JBrowse link
fluoren-9-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP 9-fluorenone results in increased expression of CYP1A1 protein CTD PMID:10445401 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP 9-fluorenone results in increased expression of CYP2B1 protein CTD PMID:10445401 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP 9-fluorenone results in increased expression of CYP3A2 protein CTD PMID:10445401 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
ledipasvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects binding ISO ledipasvir binds to ABCG2 protein CTD PMID:33954893 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO ledipasvir co-treated with sofosbuvir decreases expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425 		JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO ledipasvir co-treated sofosbuvir with affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558 		JBrowse link
lumefantrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fshb follicle stimulating hormone subunit beta decreases secretion EXP Lumefantrine results in decreased secretion of FSHB protein CTD PMID:26811345 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Prl prolactin increases secretion EXP Lumefantrine results in increased secretion of PRL protein CTD PMID:26811345 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
N-acetoxy-2-acetamidofluorene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 multiple interactions EXP [Acetoxyacetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TP53 protein CTD PMID:10741303 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
N-hydroxy-2-acetamidofluorene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression EXP Hydroxyacetylaminofluorene results in increased expression of ABCB1B mRNA; Hydroxyacetylaminofluorene results in increased expression of ABCB1B protein CTD PMID:22084566 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases activity ISO Hydroxyacetylaminofluorene results in decreased activity of NAT1 protein CTD PMID:19842618 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nat2 N-acetyltransferase 2 decreases activity ISO Hydroxyacetylaminofluorene results in decreased activity of NAT2 protein CTD PMID:19842618 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation ISO SULT2A1 protein results in increased sulfation of Hydroxyacetylaminofluorene CTD PMID:10752640 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tp53 tumor protein p53 increases expression EXP Hydroxyacetylaminofluorene results in increased expression of TP53 protein CTD PMID:9163691 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
tilorone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Tilorone results in decreased activity of ACHE protein CTD PMID:33400519 PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        xenobiotic 18728
          fluorenes 428
            (+)-(3S,4R)-3,4-dihydroxy-3,4-dihydrofluorene 0
            (+)-lucidumone 0
            (-)-lucidumone 0
            (9-oxo-2-fluorenyl)phosphonic acid 0
            1,10-dihydro-1,10-dihydroxyfluoren-9-one 0
            1-(1,3-benzodioxol-5-yl)-2-[4-(9H-fluoren-9-yl)piperazino]-1-ethanone 0
            1-Hydro-1,1a-dihydroxy-9-fluorenone 0
            1-Hydroxy-2-acetamidofluorene 0
            1-Methylfluorene 1
            1beta-hydroxy-2alpha-hydro-asterogynin A 0
            2,7-Difluoro-4-methoxyspiro[fluorene-9,5'-imidazolidine]-2',4'-dione 0
            2-(dimethylsulfamoylamino)-9H-fluorene 0
            2-Hydroxyfluorene 0
            2-[4-(9H-fluoren-9-yl)-1-piperazinyl]-N-(4-methoxyphenyl)acetamide 0
            2-[[(4-ethoxyphenyl)-oxomethyl]amino]acetic acid [2-(9H-fluoren-3-yl)-2-oxoethyl] ester 0
            2-[[5-(3-aminophenyl)-4-methyl-1,2,4-triazol-3-yl]thio]-1-(9H-fluoren-2-yl)ethanone 0
            2-\{[(9H-9-fluorenylmethoxy)carbonyl]amino\}benzoic acid 0
            2-acetamidofluorenes + 423
            2-bromo-N-(9-fluorenylideneamino)benzamide 0
            2-butoxy-7-hydroxy-9-fluorenone 0
            2-diethoxyphosphoryl-9-fluorenone 0
            3-Hydroxy-2-acetamidofluorene 0
            3-Hydroxyfluorene 0
            4-(9H-fluoren-9-yl)-N-phenyl-1-piperazinecarboxamide 0
            4-(9H-fluoren-9-yl)pyridine 0
            4-[[7-[4-[diethyl(methyl)ammonio]butoxy]-9-oxo-2-fluorenyl]oxy]butyl-diethyl-methylammonium 0
            4-[[[4-(9H-fluoren-9-yl)-1-piperazinyl]amino]methylidene]-3-hydroxy-1-cyclohexa-2,5-dienone 0
            4-acetylaminofluorene 43
            5-Hydroxy-2-acetamidofluorene 0
            7-Hydroxy-2-acetamidofluorene 0
            9,9-bis(4-hydroxyphenyl)fluorene 0
            9-(2,4,7-Trimethyl-2,3-dihydro-1H-inden-1-ylidene)-9H-fluorene 0
            9-Hydroxy-2-nitrofluorene 0
            9-hydroxy-N'-[(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-9-fluorenecarbohydrazide 0
            9-hydroxyiminofluorene-2,7-disulfonamide + 0
            9-oxo-3-fluorenecarboxylic acid (phenylmethyl) ester 0
            Allogibberic acid 0
            Asterogynin A 0
            Asterogynin B 0
            B-norviridin enol 0
            Cysfluoretin 0
            Daldinone A 0
            Daldinone C 0
            Daldinone D 0
            Daldinone F 0
            Dasyscyphin B 0
            Dasyscyphin D 0
            Dasyscyphin E 0
            Difluostatin A 0
            FIN56 0
            Fluostatin B 0
            Fluostatin C 0
            Fluostatin D 0
            Fluostatin E 0
            Fluostatin F 0
            Fluostatin G/H 0
            Fluostatin I 0
            Fluostatin J 0
            Fluostatin K 0
            Fluostatin L 0
            Fluostatin M 0
            Fluostatin N 0
            Fluostatin O 0
            Fluostatin P 0
            Fluostatin Q 0
            Flurecol 0
            Flurenol methyl ester 0
            Fmoc-lys(ME)2-OH hcl 0
            Habiterpenol 0
            Isoprekinamycin 0
            Kinafluorenone 0
            N,N,N-Trimethyl-9H-fluoren-9-aminium iodide 0
            N-(3-chlorophenyl)-4-(9H-fluoren-9-yl)-1-piperazinecarboxamide 0
            N-(4-methoxyphenyl)carbamic acid (9-fluorenylideneamino) ester 0
            N-(9-fluorenylideneamino)-4-methylaniline 0
            N-2-fluorenylphthalamic acid 0
            N-[4-(9H-fluoren-9-yl)-1-piperazinyl]-1-pyridin-4-ylethanimine 0
            N-[4-(9H-fluoren-9-yl)-1-piperazinyl]-1-pyridin-4-ylmethanimine 0
            N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide 0
            N-fluorenylacetamide 0
            N2,N7-bis(2,5-dimethylphenyl)-9H-fluorene-2,7-disulfonamide 0
            O-methoxycarbonyl-(9H-fluoren-9-yl)methanol 0
            Pyrazolofluostatin A 0
            Pyrazolofluostatin B 0
            Pyrazolofluostatin C 0
            Stealthin A 0
            Stealthin B 0
            Truncatone D 0
            UCL 1608 0
            fluoren-9-ones + 4
            hydroxy-9-fluorenones + 0
            hydroxyfluorenes + 0
            indecainide 0
            ledipasvir + 3
            lomitapide 0
            lumefantrine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            organic hydride 18691
                              organic fundamental parent 18691
                                hydrocarbon 18442
                                  cyclic hydrocarbon 17235
                                    arene 17216
                                      polycyclic arene 17041
                                        ortho-fused polycyclic arene 9838
                                          fluorene 557
                                            fluorenes 428
                                              (+)-(3S,4R)-3,4-dihydroxy-3,4-dihydrofluorene 0
                                              (+)-lucidumone 0
                                              (-)-lucidumone 0
                                              (9-oxo-2-fluorenyl)phosphonic acid 0
                                              1,10-dihydro-1,10-dihydroxyfluoren-9-one 0
                                              1-(1,3-benzodioxol-5-yl)-2-[4-(9H-fluoren-9-yl)piperazino]-1-ethanone 0
                                              1-Hydro-1,1a-dihydroxy-9-fluorenone 0
                                              1-Hydroxy-2-acetamidofluorene 0
                                              1-Methylfluorene 1
                                              1beta-hydroxy-2alpha-hydro-asterogynin A 0
                                              2,7-Difluoro-4-methoxyspiro[fluorene-9,5'-imidazolidine]-2',4'-dione 0
                                              2-(dimethylsulfamoylamino)-9H-fluorene 0
                                              2-Hydroxyfluorene 0
                                              2-[4-(9H-fluoren-9-yl)-1-piperazinyl]-N-(4-methoxyphenyl)acetamide 0
                                              2-[[(4-ethoxyphenyl)-oxomethyl]amino]acetic acid [2-(9H-fluoren-3-yl)-2-oxoethyl] ester 0
                                              2-[[5-(3-aminophenyl)-4-methyl-1,2,4-triazol-3-yl]thio]-1-(9H-fluoren-2-yl)ethanone 0
                                              2-\{[(9H-9-fluorenylmethoxy)carbonyl]amino\}benzoic acid 0
                                              2-acetamidofluorenes + 423
                                              2-bromo-N-(9-fluorenylideneamino)benzamide 0
                                              2-butoxy-7-hydroxy-9-fluorenone 0
                                              2-diethoxyphosphoryl-9-fluorenone 0
                                              3-Hydroxy-2-acetamidofluorene 0
                                              3-Hydroxyfluorene 0
                                              4-(9H-fluoren-9-yl)-N-phenyl-1-piperazinecarboxamide 0
                                              4-(9H-fluoren-9-yl)pyridine 0
                                              4-[[7-[4-[diethyl(methyl)ammonio]butoxy]-9-oxo-2-fluorenyl]oxy]butyl-diethyl-methylammonium 0
                                              4-[[[4-(9H-fluoren-9-yl)-1-piperazinyl]amino]methylidene]-3-hydroxy-1-cyclohexa-2,5-dienone 0
                                              4-acetylaminofluorene 43
                                              5-Hydroxy-2-acetamidofluorene 0
                                              7-Hydroxy-2-acetamidofluorene 0
                                              9,9-bis(4-hydroxyphenyl)fluorene 0
                                              9-(2,4,7-Trimethyl-2,3-dihydro-1H-inden-1-ylidene)-9H-fluorene 0
                                              9-Hydroxy-2-nitrofluorene 0
                                              9-hydroxy-N'-[(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-9-fluorenecarbohydrazide 0
                                              9-hydroxyiminofluorene-2,7-disulfonamide + 0
                                              9-oxo-3-fluorenecarboxylic acid (phenylmethyl) ester 0
                                              Allogibberic acid 0
                                              Asterogynin A 0
                                              Asterogynin B 0
                                              B-norviridin enol 0
                                              Cysfluoretin 0
                                              Daldinone A 0
                                              Daldinone C 0
                                              Daldinone D 0
                                              Daldinone F 0
                                              Dasyscyphin B 0
                                              Dasyscyphin D 0
                                              Dasyscyphin E 0
                                              Difluostatin A 0
                                              FIN56 0
                                              Fluostatin B 0
                                              Fluostatin C 0
                                              Fluostatin D 0
                                              Fluostatin E 0
                                              Fluostatin F 0
                                              Fluostatin G/H 0
                                              Fluostatin I 0
                                              Fluostatin J 0
                                              Fluostatin K 0
                                              Fluostatin L 0
                                              Fluostatin M 0
                                              Fluostatin N 0
                                              Fluostatin O 0
                                              Fluostatin P 0
                                              Fluostatin Q 0
                                              Flurecol 0
                                              Flurenol methyl ester 0
                                              Fmoc-lys(ME)2-OH hcl 0
                                              Habiterpenol 0
                                              Isoprekinamycin 0
                                              Kinafluorenone 0
                                              N,N,N-Trimethyl-9H-fluoren-9-aminium iodide 0
                                              N-(3-chlorophenyl)-4-(9H-fluoren-9-yl)-1-piperazinecarboxamide 0
                                              N-(4-methoxyphenyl)carbamic acid (9-fluorenylideneamino) ester 0
                                              N-(9-fluorenylideneamino)-4-methylaniline 0
                                              N-2-fluorenylphthalamic acid 0
                                              N-[4-(9H-fluoren-9-yl)-1-piperazinyl]-1-pyridin-4-ylethanimine 0
                                              N-[4-(9H-fluoren-9-yl)-1-piperazinyl]-1-pyridin-4-ylmethanimine 0
                                              N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide 0
                                              N-fluorenylacetamide 0
                                              N2,N7-bis(2,5-dimethylphenyl)-9H-fluorene-2,7-disulfonamide 0
                                              O-methoxycarbonyl-(9H-fluoren-9-yl)methanol 0
                                              Pyrazolofluostatin A 0
                                              Pyrazolofluostatin B 0
                                              Pyrazolofluostatin C 0
                                              Stealthin A 0
                                              Stealthin B 0
                                              Truncatone D 0
                                              UCL 1608 0
                                              fluoren-9-ones + 4
                                              hydroxy-9-fluorenones + 0
                                              hydroxyfluorenes + 0
                                              indecainide 0
                                              ledipasvir + 3
                                              lomitapide 0
                                              lumefantrine 2
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