ethanediol - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	ethanediol	go back to main search page
Accession:	CHEBI:23976	browse the term
Definition:	Any diol that is ethane or substituted ethane carrying two hydroxy groups.
Synonyms:	related_synonym:	ethanediols

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Rat (165) Mouse (164) Human (167) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (165)

2-ethoxyethanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 2

increases expression

2-ethoxyethanol results in increased expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

AKT serine/threonine kinase 3

increases expression

2-ethoxyethanol results in increased expression of AKT3 mRNA

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

aldehyde dehydrogenase 2 family member

increases reaction

ALDH2 protein promotes the reaction 2-ethoxyethanol

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

amyloid beta precursor protein

increases expression

2-ethoxyethanol results in increased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

ARF GTPase 3

increases expression

2-ethoxyethanol results in increased expression of ARF3 mRNA

NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002

G

activating transcription factor 2

increases expression

2-ethoxyethanol results in increased expression of ATF2 mRNA

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

BAG cochaperone 6

increases expression

2-ethoxyethanol results in increased expression of BAG6 mRNA

NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657

G

Bcl2-like 1

increases expression

2-ethoxyethanol results in increased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

catalase

decreases activity

2-ethoxyethanol results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

increases expression

2-ethoxyethanol results in increased expression of CAV mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

CCAAT/enhancer binding protein gamma

increases expression

2-ethoxyethanol results in increased expression of CEBPG mRNA

NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569

G

carboxyl ester lipase

increases expression

2-ethoxyethanol results in increased expression of CEL mRNA

NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035

G

calcineurin-like EF-hand protein 1

increases expression

2-ethoxyethanol results in increased expression of CHP1 mRNA

NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251

G

clathrin heavy chain

increases expression

2-ethoxyethanol results in increased expression of CLTC mRNA

NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737

G

casein kinase 1, alpha 1

increases expression

2-ethoxyethanol results in increased expression of CSNK1A1 mRNA

NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271

G

casein kinase 1, delta

increases expression

2-ethoxyethanol results in increased expression of CSNK1D mRNA

NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614

G

casein kinase 1, gamma 3

increases expression

2-ethoxyethanol results in increased expression of CSNK1G3 mRNA

NCBI chr18:47,299,547...47,386,538
Ensembl chr18:47,299,579...47,386,535

G

cortactin

increases expression

2-ethoxyethanol results in increased expression of CTTN mRNA

NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164

G

7-dehydrocholesterol reductase

increases expression

2-ethoxyethanol results in increased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

dynein cytoplasmic 1 light intermediate chain 1

decreases expression

2-ethoxyethanol results in decreased expression of DYNC1LI1 mRNA

NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934

G

elongin A

increases expression

2-ethoxyethanol results in increased expression of ELOA mRNA

NCBI chr 5:148,231,600...148,246,760
Ensembl chr 5:148,231,596...148,246,765

G

enolase 2

increases expression

2-ethoxyethanol results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

epsin 2

increases expression

2-ethoxyethanol results in increased expression of EPN2 mRNA

NCBI chr10:46,197,785...46,259,673
Ensembl chr10:46,197,785...46,259,642

G

GATA binding protein 4

increases expression

2-ethoxyethanol results in increased expression of GATA4 mRNA

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

GATA binding protein 6

increases expression

2-ethoxyethanol results in increased expression of GATA6 mRNA

NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532

G

GDP dissociation inhibitor 2

increases expression

2-ethoxyethanol results in increased expression of GDI2 mRNA

NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366

G

hexokinase 1

increases expression

2-ethoxyethanol results in increased expression of HK1 mRNA

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

hexokinase 2

increases expression

2-ethoxyethanol results in increased expression of HK2 mRNA

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

insulin-like growth factor 2

increases expression

2-ethoxyethanol results in increased expression of IGF2 mRNA

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

Janus kinase 2

increases expression

2-ethoxyethanol results in increased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

LYN proto-oncogene, Src family tyrosine kinase

increases expression

2-ethoxyethanol results in increased expression of LYN mRNA

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

mitogen activated protein kinase kinase kinase 12

decreases expression

2-ethoxyethanol results in decreased expression of MAP3K12 mRNA

NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789

G

mitogen activated protein kinase 1

increases expression

2-ethoxyethanol results in increased expression of MAPK1 mRNA

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 10

increases expression

2-ethoxyethanol results in increased expression of MAPK10 mRNA

NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201

G

MAX interactor 1, dimerization protein

increases expression

2-ethoxyethanol results in increased expression of MXI1 mRNA

NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681

G

Ngfi-A binding protein 1

increases expression

2-ethoxyethanol results in increased expression of NAB1 mRNA

NCBI chr 9:49,053,579...49,093,078
Ensembl chr 9:49,053,758...49,092,098

G

nuclear factor I/A

increases expression

2-ethoxyethanol results in increased expression of NFIA mRNA

NCBI chr 5:112,436,655...112,781,878
Ensembl chr 5:112,436,644...112,775,885

G

nuclear receptor subfamily 2, group F, member 2

increases expression

2-ethoxyethanol results in increased expression of NR2F2 mRNA

NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031

G

p21 (RAC1) activated kinase 2

increases expression

2-ethoxyethanol results in increased expression of PAK2 mRNA

NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

increases expression

2-ethoxyethanol results in increased expression of PFKFB2 mRNA

NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699

G

phospholipase A2 group 4A

increases expression

2-ethoxyethanol results in increased expression of PLA2G4A mRNA

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

G

phospholipase C beta 3

increases expression

2-ethoxyethanol results in increased expression of PLCB3 mRNA

NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228

G

POU class 2 homeobox 3

increases expression

2-ethoxyethanol results in increased expression of POU2F3 mRNA

NCBI chr 8:43,495,408...43,577,795
Ensembl chr 8:43,495,527...43,577,795

G

protein kinase cAMP-dependent type II regulatory subunit alpha

increases expression

2-ethoxyethanol results in increased expression of PRKAR2A mRNA

NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628

G

RAB5A, member RAS oncogene family

increases expression

2-ethoxyethanol results in increased expression of RAB5A mRNA

NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873

G

ring finger protein 4

increases expression

2-ethoxyethanol results in increased expression of RNF4 mRNA

NCBI chr14:76,401,292...76,423,270
Ensembl chr14:76,401,299...76,422,566

G

ROS proto-oncogene 1 , receptor tyrosine kinase

increases expression

2-ethoxyethanol results in increased expression of ROS1 mRNA

NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865

G

SEC14-like lipid binding 2

increases expression

2-ethoxyethanol results in increased expression of SEC14L2 mRNA

NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788

G

salt-inducible kinase 1

increases expression

2-ethoxyethanol results in increased expression of SIK1 mRNA

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

SNF related kinase

increases expression

2-ethoxyethanol results in increased expression of SNRK mRNA

NCBI chr 8:121,779,704...121,833,949
Ensembl chr 8:121,793,302...121,832,323

G

sorting nexin 16

increases expression

2-ethoxyethanol results in increased expression of SNX16 mRNA

NCBI chr 2:91,335,896...91,357,622
Ensembl chr 2:91,336,092...91,357,619

G

sterol O-acyltransferase 1

increases expression

2-ethoxyethanol results in increased expression of SOAT1 mRNA

NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494

G

serine/threonine kinase 17b

increases expression

2-ethoxyethanol results in increased expression of STK17B mRNA

NCBI chr 9:55,307,485...55,338,085
Ensembl chr 9:55,307,668...55,338,031

G

syntaxin 2

increases expression

2-ethoxyethanol results in increased expression of STX2 mRNA

NCBI chr12:27,678,744...27,714,751
Ensembl chr12:27,689,819...27,714,751

G

syntaxin binding protein 1

increases expression

2-ethoxyethanol results in increased expression of STXBP1 mRNA

NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369

G

synaptonemal complex protein 1

decreases expression

2-ethoxyethanol results in decreased expression of SYCP1 mRNA

NCBI chr 2:190,296,688...190,456,687
Ensembl chr 2:190,296,954...190,456,737

G

synaptonemal complex protein 2

decreases expression

2-ethoxyethanol results in decreased expression of SYCP2 mRNA

NCBI chr 3:165,431,715...165,502,134
Ensembl chr 3:165,436,331...165,498,789

G

synaptonemal complex protein 3

decreases expression

2-ethoxyethanol results in decreased expression of SYCP3 mRNA

NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511

G

TLE family member 4, transcriptional corepressor

increases expression

2-ethoxyethanol results in increased expression of TLE4 mRNA

NCBI chr 1:211,661,738...211,798,458
Ensembl chr 1:211,661,746...211,797,862

G

transmembrane p24 trafficking protein 2

increases expression

2-ethoxyethanol results in increased expression of TMED2 mRNA

NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903

G

WT1 transcription factor

increases expression

2-ethoxyethanol results in increased expression of WT1 mRNA

NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643

G

YY1 transcription factor

increases expression

2-ethoxyethanol results in increased expression of YY1 mRNA

NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747

2-hydroxyethyl methacrylate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenomedullin

increases expression

hydroxyethyl methacrylate results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

aldo-keto reductase family 1, member C2

increases expression

hydroxyethyl methacrylate results in increased expression of AKR1C2 mRNA

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 1, member C3

increases expression

hydroxyethyl methacrylate results in increased expression of AKR1C3 mRNA

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

aldehyde dehydrogenase 3 family, member A2

increases expression

hydroxyethyl methacrylate results in increased expression of ALDH3A2 mRNA

NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281

G

autophagy related 5

increases expression
multiple interactions

hydroxyethyl methacrylate results in increased expression of ATG5 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

beclin 1

increases expression
multiple interactions

hydroxyethyl methacrylate results in increased expression of BECN1 mRNA; hydroxyethyl methacrylate results in increased expression of BECN1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

caspase 3

increases activity
multiple interactions

hydroxyethyl methacrylate results in increased activity of CASP3 protein
Ascorbic Acid inhibits the reaction [hydroxyethyl methacrylate results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions
increases expression

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

Ascorbic Acid inhibits the reaction [hydroxyethyl methacrylate results in increased degradation of CAT mRNA]; hydroxyethyl methacrylate results in increased expression of and results in increased degradation of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

collagen type I alpha 1 chain

decreases expression

hydroxyethyl methacrylate results in decreased expression of COL1A1 mRNA; hydroxyethyl methacrylate results in decreased expression of COL1A1 protein

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

C-X-C motif chemokine ligand 12

decreases expression

hydroxyethyl methacrylate results in decreased expression of CXCL12 protein

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

hydroxyethyl methacrylate results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

F-box protein 30

increases expression

hydroxyethyl methacrylate results in increased expression of FBXO30 mRNA

NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441

G

fibroblast growth factor 2

multiple interactions
increases secretion

Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

ferritin heavy chain 1

increases expression

hydroxyethyl methacrylate results in increased expression of FTH1 mRNA

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

glutamate-cysteine ligase, catalytic subunit

increases expression

hydroxyethyl methacrylate results in increased expression of GCLC mRNA; hydroxyethyl methacrylate results in increased expression of GCLC protein

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

hydroxyethyl methacrylate results in increased expression of GCLM mRNA; hydroxyethyl methacrylate results in increased expression of GCLM protein

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

H2A.X variant histone

increases expression

hydroxyethyl methacrylate results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

heme oxygenase 1

increases expression

hydroxyethyl methacrylate results in increased expression of HMOX1 mRNA; hydroxyethyl methacrylate results in increased expression of HMOX1 protein

PMID:30497689 PMID:33248029

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 1A

increases expression

hydroxyethyl methacrylate results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

increases expression

hydroxyethyl methacrylate results in increased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

interleukin 1 alpha

multiple interactions
increases secretion

Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of IL1A protein]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

2-oxothiazolidine-4-carboxylic acid inhibits the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Buthionine Sulfoximine promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; hydroxyethyl methacrylate promotes the reaction [triethylene glycol dimethacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; triethylene glycol dimethacrylate promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]

PMID:23182953 PMID:28188892

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

decreases secretion

hydroxyethyl methacrylate results in decreased secretion of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

lactate dehydrogenase A

increases activity

hydroxyethyl methacrylate results in increased activity of LDHA protein

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

microtubule-associated protein 1 light chain 3 beta

increases expression
multiple interactions

hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA; hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen-activated protein kinase kinase kinase 14

increases expression

hydroxyethyl methacrylate results in increased expression of MAP3K14 mRNA

NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523

G

mitochondrial ribosomal protein L19

increases expression

hydroxyethyl methacrylate results in increased expression of MRPL19 mRNA

NCBI chr 4:114,521,824...114,526,053
Ensembl chr 4:114,521,824...114,526,053

G

NFE2 like bZIP transcription factor 2

increases expression

hydroxyethyl methacrylate results in increased expression of NFE2L2 protein

PMID:30497689 PMID:37778984

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

increases response to substance
multiple interactions

NFKBIA protein results in increased susceptibility to hydroxyethyl methacrylate
NFKBIA protein affects the reaction [Acetylcysteine results in decreased susceptibility to hydroxyethyl methacrylate]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NAD(P)H quinone dehydrogenase 1

increases expression

hydroxyethyl methacrylate results in increased expression of NQO1 mRNA; hydroxyethyl methacrylate results in increased expression of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

oxidative stress induced growth inhibitor 1

increases expression

hydroxyethyl methacrylate results in increased expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein]; hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein; hydroxyethyl methacrylate affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein; hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein]

PMID:19176594 PMID:28184909

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

splA/ryanodine receptor domain and SOCS box containing 1

increases expression

hydroxyethyl methacrylate results in increased expression of SPSB1 mRNA

NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468

G

sequestosome 1

increases expression

hydroxyethyl methacrylate results in increased expression of SQSTM1 mRNA; hydroxyethyl methacrylate results in increased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sulfiredoxin 1

increases expression

hydroxyethyl methacrylate results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

tumor necrosis factor

multiple interactions

hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein]
hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; hydroxyethyl methacrylate promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

PMID:19176594 PMID:23182953 PMID:28188892

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

thioredoxin reductase 1

increases expression

hydroxyethyl methacrylate results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

UDP-glucose 6-dehydrogenase

increases expression

hydroxyethyl methacrylate results in increased expression of UGDH mRNA

NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354

G

vascular endothelial growth factor A

multiple interactions
decreases secretion

Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

chloral hydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 2 family member

multiple interactions

[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde

PMID:18272654 PMID:21334317 PMID:21376711

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions

Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B2 mRNA]

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases chemical synthesis
multiple interactions

CYP2E1 protein results in increased chemical synthesis of Chloral Hydrate
[CYP2E1 protein results in increased metabolism of Trichloroethylene] which results in increased chemical synthesis of Chloral Hydrate

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Chloral Hydrate inhibits the reaction [Cocaine results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

gamma-aminobutyric acid type B receptor subunit 1

multiple interactions

Chloral Hydrate inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]

NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994

G

gamma-aminobutyric acid type A receptor subunit alpha 2

multiple interactions

Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]

NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944

G

gamma-aminobutyric acid type A receptor subunit beta1

multiple interactions

Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]

NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948

G

gastrin

multiple interactions

Chloral Hydrate inhibits the reaction [GAST protein results in increased secretion of Histamine]

NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496

G

gap junction protein, alpha 1

decreases expression
increases expression

Chloral Hydrate results in decreased expression of GJA1 mRNA; Chloral Hydrate results in decreased expression of GJA1 protein
Chloral Hydrate results in increased expression of GJA1 protein

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, beta 2

decreases expression
increases expression

Chloral Hydrate results in decreased expression of GJB2 mRNA
Chloral Hydrate results in increased expression of GJB2 protein

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

glycine receptor, alpha 1

multiple interactions

Chloral Hydrate promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]

NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162

G

heme oxygenase 1

affects expression

Chloral Hydrate affects the expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 1 beta

increases expression
multiple interactions

Chloral Hydrate results in increased expression of IL1B mRNA
Ozone inhibits the reaction [Chloral Hydrate results in increased expression of IL1B mRNA]

PMID:15207037 PMID:15207038

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression

Chloral Hydrate results in increased expression of IL6 mRNA

PMID:15207037 PMID:15207038

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

solute carrier family 2 member 1

multiple interactions

Chloral Hydrate inhibits the reaction [SLC2A1 protein results in increased transport of Glucose]

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

ethylene glycol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

increases oxidation

ADH1C protein results in increased oxidation of Ethylene Glycol

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

alcohol dehydrogenase 4 (class II), pi polypeptide

increases oxidation

ADH4 protein results in increased oxidation of Ethylene Glycol

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

increases oxidation

ADH7 protein results in increased oxidation of Ethylene Glycol

NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182

G

aldehyde dehydrogenase 1 family, member A2

decreases expression

Ethylene Glycol results in decreased expression of ALDH1A2 mRNA

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

activating transcription factor 4

increases expression
multiple interactions

Ethylene Glycol results in increased expression of ATF4 mRNA
caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of ATF4 mRNA]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

BCL2 associated X, apoptosis regulator

multiple interactions
decreases expression

caryophyllene inhibits the reaction [Ethylene Glycol results in decreased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
increases expression

caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

complement C5

multiple interactions

[Ethylene Glycol co-treated with Asbestos, Crocidolite] results in increased cleavage of C5 protein; [Ethylene Glycol co-treated with Asbestos, Serpentine] results in increased cleavage of C5 protein

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

caspase 3

multiple interactions
decreases expression

caryophyllene inhibits the reaction [Ethylene Glycol results in decreased expression of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions
decreases expression

caryophyllene inhibits the reaction [Ethylene Glycol results in decreased expression of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity
increases activity
multiple interactions

Ethylene Glycol results in decreased activity of CAT protein
Ethylene Glycol results in increased activity of CAT protein
acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased activity of CAT protein]; caryophyllene inhibits the reaction [Ethylene Glycol results in decreased activity of CAT protein]

PMID:24145091 PMID:27018375 PMID:34468068

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

increases expression
affects expression
multiple interactions

Ethylene Glycol results in increased expression of CCL2 mRNA
Ethylene Glycol affects the expression of CCL2 mRNA
Ethylene Glycol results in increased expression of CCL2 mRNA; Ethylene Glycol results in increased expression of CCL2 protein
[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 mRNA]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein]; caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 mRNA]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]; Vitamin K 1 affects the reaction [Ethylene Glycol affects the expression of CCL2 mRNA]

PMID:16284884 PMID:21907259 PMID:27018375 PMID:31639794 PMID:34468068 More...

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

increases expression
multiple interactions

Ethylene Glycol results in increased expression of CCL5 protein
benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]; PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

CD44 molecule

increases expression
multiple interactions

Ethylene Glycol results in increased expression of CD44 mRNA; Ethylene Glycol results in increased expression of CD44 protein
[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein]

PMID:37244400 PMID:37414240

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cytochrome P450, family 2, subfamily c, polypeptide 7

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CYP2C9 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CYP2C9 mRNA]

NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709

G

DNA-damage inducible transcript 3

decreases expression
multiple interactions

Ethylene Glycol results in decreased expression of DDIT3 mRNA
caryophyllene inhibits the reaction [Ethylene Glycol results in decreased expression of DDIT3 mRNA]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

EYA transcriptional coactivator and phosphatase 1

decreases expression

Ethylene Glycol results in decreased expression of EYA1 mRNA

NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483

G

forkhead box C2

decreases expression

Ethylene Glycol results in decreased expression of FOXC2 mRNA

NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737

G

growth hormone 1

affects folding

Ethylene Glycol affects the folding of GH1 protein

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

hepatitis A virus cellular receptor 1

increases expression
multiple interactions

Ethylene Glycol results in increased expression of HAVCR1 mRNA
caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of HAVCR1 mRNA]

PMID:21907259 PMID:34468068

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

histone deacetylase 1

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA]

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

histone deacetylase 2

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA]

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

histone deacetylase 3

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA]

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

G

histone deacetylase 8

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA]

NCBI chr X:67,385,288...67,593,014
Ensembl chr X:67,385,289...67,592,923

G

homeo box B7

increases expression

Ethylene Glycol results in increased expression of HOXB7 mRNA

NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of HSPA5 mRNA]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

interleukin 6

increases expression
multiple interactions

Ethylene Glycol results in increased expression of IL6 mRNA; Ethylene Glycol results in increased expression of IL6 protein
[Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of IL6 mRNA]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]

PMID:16284884 PMID:27018375 PMID:27241030

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mesenchyme homeobox 1

decreases expression

Ethylene Glycol results in decreased expression of MEOX1 mRNA

NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660

G

matrix Gla protein

multiple interactions
increases expression

[Vitamin K 1 co-treated with Ethylene Glycol] results in increased expression of MGP protein
Ethylene Glycol results in increased expression of MGP protein

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

G

neurofilament heavy chain

affects expression

Ethylene Glycol affects the expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

neurogenin 2

increases expression

Ethylene Glycol results in increased expression of NEUROG2 mRNA

NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154

G

nuclear factor kappa B subunit 1

multiple interactions
increases expression

benazepril inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]; PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

occludin

decreases expression

Ethylene Glycol results in decreased expression of OCLN mRNA

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

oligodendrocyte transcription factor 3

increases expression

Ethylene Glycol results in increased expression of OLIG3 mRNA

NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149

G

paired box 3

decreases expression

Ethylene Glycol results in decreased expression of PAX3 mRNA

NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases expression

acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of RELA mRNA]; caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of RELA mRNA]

PMID:27018375 PMID:34468068

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 26 member 1

increases expression

Ethylene Glycol results in increased expression of SLC26A1 protein

NCBI chr14:1,040,565...1,045,851
Ensembl chr14:1,040,243...1,045,849

G

secreted phosphoprotein 1

multiple interactions
increases expression

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein; [Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of SPP1 protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of SPP1 protein]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein]
Ethylene Glycol results in increased expression of SPP1 mRNA; Ethylene Glycol results in increased expression of SPP1 protein

PMID:24145091 PMID:27018375 PMID:27241030 PMID:37244400 PMID:37414240

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

transcription factor 15

decreases expression

Ethylene Glycol results in decreased expression of TCF15 mRNA

NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766

G

transferrin

multiple interactions
increases expression

[Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of TF protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of TF protein]

PMID:27018375 PMID:27241030

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

tight junction protein 1

decreases expression

Ethylene Glycol results in decreased expression of TJP1 mRNA

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

tumor necrosis factor

increases expression
multiple interactions

Ethylene Glycol results in increased expression of TNF mRNA; Ethylene Glycol results in increased expression of TNF protein
[Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of TNF protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of TNF mRNA]

PMID:27018375 PMID:27241030

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

uromodulin

multiple interactions
increases expression

[Flavonoids co-treated with Plant Extracts] inhibits the reaction [Ethylene Glycol results in increased expression of UMOD protein]; acrylic acid analog inhibits the reaction [Ethylene Glycol results in increased expression of and affects the localization of UMOD protein]; Ethylene Glycol results in increased expression of and affects the localization of UMOD protein

PMID:27018375 PMID:27241030

NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302

G

UNC homeobox

decreases expression

Ethylene Glycol results in decreased expression of UNCX mRNA

NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300

G

vanin 1

increases expression

Ethylene Glycol results in increased expression of VNN1 mRNA; Ethylene Glycol results in increased expression of VNN1 protein

NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395

G

X-box binding protein 1

increases expression
multiple interactions

Ethylene Glycol results in increased expression of XBP1 mRNA
caryophyllene inhibits the reaction [Ethylene Glycol results in increased expression of XBP1 mRNA]

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

ethylene glycol dimethacrylate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1, member C2

increases activity

ethylene dimethacrylate results in increased activity of AKR1C2 promoter

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

activating transcription factor 3

increases expression

ethylene dimethacrylate results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

BTB domain and CNC homolog 1

multiple interactions

BACH1 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA]

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

CD86 molecule

increases expression

ethylene dimethacrylate results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

C-X-C motif chemokine ligand 14

decreases expression

ethylene dimethacrylate results in decreased expression of CXCL14 protein

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

C-X-C motif chemokine ligand 2

increases expression

ethylene dimethacrylate results in increased expression of CXCL2 protein

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

glutamate cysteine ligase, modifier subunit

increases expression

ethylene dimethacrylate results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione peroxidase 4

increases expression

ethylene dimethacrylate results in increased expression of GPX4

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

heme oxygenase 1

increases expression
multiple interactions

ethylene dimethacrylate results in increased expression of HMOX1 mRNA
BACH1 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 1 alpha

increases expression

ethylene dimethacrylate results in increased expression of IL1A protein

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

NFE2 like bZIP transcription factor 2

multiple interactions

NFE2L2 mRNA promotes the reaction [ethylene dimethacrylate results in increased expression of HMOX1 mRNA]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

superoxide dismutase 2

increases expression

ethylene dimethacrylate results in increased expression of SOD2

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

macitentan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases expression

macitentan results in decreased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

decreases expression

macitentan results in decreased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

decreases expression

macitentan results in decreased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

solute carrier family 10 member 1

decreases expression

macitentan results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19874
chemical entity	19872
molecular entity	19872
polyatomic entity	19824
heteroatomic molecular entity	19781
hydroxides	19341
organic hydroxy compound	18951
polyol	11690
diol	3938
ethanediol	165
1-(3,4-dimethoxyphenyl)ethane-1,2-diol	0
chloral hydrate	16
ethylene glycol +	153
hydrobenzoin +	0
Path 2
Term	Annotations
CHEBI ontology	19874
subatomic particle	19872
composite particle	19872
hadron	19872
baryon	19872
nucleon	19872
atomic nucleus	19872
atom	19872
main group element atom	19811
p-block element atom	19811
p-block molecular entity	19811
chalcogen molecular entity	19563
oxygen molecular entity	19535
hydroxides	19341
organic hydroxy compound	18951
polyol	11690
diol	3938
ethanediol	165
1-(3,4-dimethoxyphenyl)ethane-1,2-diol	0
chloral hydrate	16
ethylene glycol +	153
hydrobenzoin +	0

paths to the root