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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetochlor
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Accession:CHEBI:2394 term browser browse the term
Definition:A monocarboxylic acid amide that is N-phenylacetamide carrying an ethyl and a methyl group at positions 2 and 6 respectively on the benzene ring while one of the methyl hydrogens as well as the hydrogen attached to the nitrogen atom have been replaced by a chloro and an ethoxymethyl group respectively.
Synonyms:exact_synonym: 2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)acetamide
 related_synonym: 2-Chloro-2'-methyl-6-ethyl-N-ethoxymethylacetanilide;   2-Chloro-N-(ethoxymethyl)-6'-ethyl-o-acetotoluidide;   2-Chloro-N-(ethoxymethyl)-6'-ethylacet-o-toluidide;   Acetochlore;   Formula=C14H20ClNO2;   InChI=1S/C14H20ClNO2/c1-4-12-8-6-7-11(3)14(12)16(10-18-5-2)13(17)9-15/h6-8H,4-5,9-10H2,1-3H3;   InChIKey=VTNQPKFIQCLBDU-UHFFFAOYSA-N;   SMILES=CCOCN(C(=O)CCl)c1c(C)cccc1CC
 xref: CAS:34256-82-1;   KEGG:C10925
 xref_mesh: MESH:C043377
 xref: PMID:16646021;   PMID:17534384;   PPDB:12;   Pesticides:acetochlor;   Reaxys:2859702;   Wikipedia:Acetochlor


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acetochlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases activity
multiple interactions		 ISO acetochlor results in increased activity of ABCB1 protein
ABCB1 protein affects the reaction [acetochlor results in increased susceptibility to Paclitaxel]		 CTD PMID:18433974 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases export ISO ABCC1 protein results in increased export of acetochlor metabolite CTD PMID:18433974 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114 		JBrowse link
G Aplf aprataxin and PNKP like factor affects response to substance ISO APLF gene SNP affects the susceptibility to acetochlor CTD PMID:25622337 NCBI chr 4:121,627,800...121,679,980
Ensembl chr 4:120,070,471...120,122,633 		JBrowse link
G Ar androgen receptor multiple interactions ISO acetochlor inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO acetochlor results in increased expression of BAD protein CTD PMID:25291404 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO acetochlor results in increased expression of BAK1 protein CTD PMID:25291404 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO acetochlor results in increased expression of BAX protein CTD PMID:25291404 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression ISO acetochlor affects the expression of BCL2L1 protein CTD PMID:25291404 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO acetochlor results in increased expression of BID protein CTD PMID:25291404 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [acetochlor results in increased expression of CASP3 protein modified form] CTD PMID:25291404 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [acetochlor results in increased cleavage of CASP9 protein] CTD PMID:25291404 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of acetochlor CTD PMID:11133395 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of acetochlor CTD PMID:11133395 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO acetochlor binds to and results in decreased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO acetochlor binds to and results in decreased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Gfral GDNF family receptor alpha like affects response to substance ISO GFRAL gene SNP affects the susceptibility to acetochlor CTD PMID:25622337 NCBI chr 8:85,798,337...85,843,705
Ensembl chr 8:76,918,657...76,959,425 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [acetochlor results in increased phosphorylation of MAPK1 protein] CTD PMID:25291404 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO acetochlor results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [acetochlor results in increased phosphorylation of MAPK3 protein]		 CTD PMID:25291404 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression ISO acetochlor affects the expression of MCL1 protein CTD PMID:25291404 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Msl1 MSL complex subunit 1 multiple interactions ISO [Herbicides results in increased abundance of acetochlor] which affects the methylation of MSL1 gene CTD PMID:34516295 NCBI chr10:83,755,380...83,767,147
Ensembl chr10:83,755,720...83,765,726 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO acetochlor binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [acetochlor results in increased cleavage of PARP1 protein] CTD PMID:25291404 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO acetochlor binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 multiple interactions ISO [Herbicides results in increased abundance of acetochlor] which affects the methylation of QSOX1 gene CTD PMID:34516295 NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459 		JBrowse link
G Rimklb ribosomal modification protein rimK-like family member B affects response to substance ISO RIMKLB gene SNP affects the susceptibility to acetochlor CTD PMID:25622337 NCBI chr 4:157,336,950...157,396,970
Ensembl chr 4:155,664,375...155,706,711 		JBrowse link
G Rnf126 ring finger protein 126 multiple interactions ISO [Herbicides results in increased abundance of acetochlor] which affects the methylation of RNF126 gene CTD PMID:34516295 NCBI chr 7:10,590,013...10,597,585
Ensembl chr 7:9,938,229...9,946,738 		JBrowse link
G Rrp9 ribosomal RNA processing 9, U3 small nucleolar RNA binding protein multiple interactions ISO [Herbicides results in increased abundance of acetochlor] which affects the methylation of RRP9 gene CTD PMID:34516295 NCBI chr 8:115,995,119...116,004,832
Ensembl chr 8:107,117,471...107,126,123 		JBrowse link
G Thrb thyroid hormone receptor beta affects binding
multiple interactions		 ISO acetochlor binds to THRB protein
acetochlor binds to and results in decreased activity of THRB protein		 CTD PMID:28973306 PMID:33049310 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Ttc7b tetratricopeptide repeat domain 7B multiple interactions ISO [Herbicides results in increased abundance of acetochlor] which affects the methylation of TTC7B gene CTD PMID:34516295 NCBI chr 6:119,587,389...119,799,167
Ensembl chr 6:119,587,390...119,799,330 		JBrowse link
Term paths to the root
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  CHEBI ontology 19909
    role 19880
      biological role 19878
        xenobiotic 18757
          acetochlor 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    main group molecular entity 19846
                      s-block molecular entity 19679
                        hydrogen molecular entity 19661
                          hydrides 19163
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18079
                                  azane 17889
                                    ammonia 17888
                                      organic amino compound 17888
                                        primary amino compound 9365
                                          primary amine 6374
                                            primary arylamine 3705
                                              aniline 3545
                                                anilide 1183
                                                  N-phenylacetamide 235
                                                    acetochlor 29
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