cyclohexanols - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	cyclohexanols	go back to main search page
Accession:	CHEBI:23480	browse the term
Definition:	An alcohol in which one or more hydroxy groups are attached to a cyclohexane skeleton.
Synonyms:	xref_mesh:	MESH:D003511

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Rat (235) Mouse (236) Human (236) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (235)

cyclohexanols

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Diethylnitrosamine co-treated with Cyclohexanols] results in decreased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

[Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

ezrin

increases expression

Cyclohexanols results in increased expression of EZR mRNA

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

glutathione S-transferase pi 1

multiple interactions

[Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

marker of proliferation Ki-67

multiple interactions

[Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

proliferating cell nuclear antigen

multiple interactions

[Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

(R,R)-tramadol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

increases expression

Tramadol results in increased expression of ADRA1A protein

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

BCL2 associated X, apoptosis regulator

increases expression

Tramadol results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

decreases activity

Tramadol results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

caspase 3

affects activity
multiple interactions
increases expression
decreases activity

Tramadol affects the activity of CASP3 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased activity of CASP3 protein

PMID:27317026 PMID:28499616 PMID:31618080

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases expression
multiple interactions

Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]

PMID:25550769 PMID:31618080

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

creatine kinase B

decreases expression
multiple interactions

Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

PMID:27317026 PMID:33645892

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

creatine kinase, M-type

multiple interactions

Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

Tramadol results in decreased activity of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing

CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol

PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More...

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

desmin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of DES protein]

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

dopamine receptor D2

increases expression

Tramadol results in increased expression of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

increases expression

Tramadol results in increased expression of DRD3 protein

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

gap junction protein, alpha 1

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glutamic-oxaloacetic transaminase 1

multiple interactions
increases expression

Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

increases activity
multiple interactions
increases expression

Tramadol results in increased activity of GPT protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]

PMID:28689766 PMID:31618080

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

5-hydroxytryptamine receptor 2A

increases activity
increases expression
multiple interactions

Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

interferon gamma

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

lactate dehydrogenase A

decreases expression

Tramadol results in decreased expression of LDHA mRNA

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

NADH:ubiquinone oxidoreductase core subunit S1

decreases expression

Tramadol results in decreased expression of NDUFS1 mRNA

NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893

G

opioid receptor, delta 1

affects binding
multiple interactions

Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects binding
multiple interactions

Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

affects binding
multiple interactions

Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

pyruvate dehydrogenase kinase 3

increases expression

Tramadol results in increased expression of PDK3 mRNA

NCBI chr X:58,486,699...58,553,533
Ensembl chr X:58,486,554...58,553,557

G

prodynorphin

decreases expression

Tramadol results in decreased expression of PDYN mRNA

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

solute carrier family 2 member 4

multiple interactions

Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 47 member 1

multiple interactions

Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

superoxide dismutase 1

decreases expression
multiple interactions

Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]

PMID:25550769 PMID:31618080

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
decreases expression

Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

multiple interactions
increases expression

Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

tumor necrosis factor

multiple interactions
increases expression

[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]

PMID:17377112 PMID:31618080 PMID:33645892

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

troponin I3, cardiac type

multiple interactions
increases expression

Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

G

vimentin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

SB-239063

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aquaporin 4

multiple interactions

SB 239063 inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein]

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

activating transcription factor 4

multiple interactions

SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of ATF4 protein]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

BCL2, apoptosis regulator

multiple interactions

SB 239063 inhibits the reaction [Particulate Matter results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions

SB 239063 inhibits the reaction [prostaglandin E2 glyceryl ester results in increased cleavage of and results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

C-X-C motif chemokine ligand 3

multiple interactions

[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of CXCL1 mRNA]]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

SB 239063 inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein]

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

DNA-damage inducible transcript 3

multiple interactions

SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dynamin 1-like

multiple interactions

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in decreased expression of DNM1L protein

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

dual specificity phosphatase 1

multiple interactions

SB 239063 inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] promotes the reaction [Ovalbumin results in decreased expression of DUSP1 protein]]

NCBI chr10:16,680,478...16,683,275

G

endothelin receptor type B

multiple interactions

SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB mRNA]; SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB protein]

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

glutathione peroxidase 1

multiple interactions

[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ovalbumin promotes the reaction [Ozone results in increased activity of GPX1 protein]]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glycogen synthase kinase 3 beta

multiple interactions

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

heat shock protein family B (small) member 1

multiple interactions

SB 239063 inhibits the reaction [[[Air Pollutants results in increased abundance of Ozone] which co-treated with Ovalbumin] results in increased phosphorylation of HSPB1 protein]

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

interferon gamma

multiple interactions

SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IFNG protein]]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 13

multiple interactions

[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]]; SB 239063 inhibits the reaction [Ovalbumin results in increased expression of IL13 protein]; SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]]

PMID:25287866 PMID:29284473

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 17A

multiple interactions

SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL17A mRNA]]

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 6

multiple interactions

SB 239063 inhibits the reaction [Ovalbumin results in increased expression of IL6 protein]; SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL6 protein]]

PMID:25287866 PMID:29284473

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

multiple interactions

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

SB 239063 inhibits the reaction [[[Air Pollutants results in increased abundance of Ozone] which co-treated with Ovalbumin] results in increased phosphorylation of MAPK14 protein]; SB 239063 inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] promotes the reaction [Ovalbumin results in increased phosphorylation of MAPK14 protein]]; SB 239063 inhibits the reaction [[Ovalbumin co-treated with Ozone] results in increased phosphorylation of MAPK14 protein]; SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased phosphorylation of MAPK14 protein]]

PMID:24188200 PMID:25287866 PMID:29284473

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitochondrial fission factor

multiple interactions

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in decreased expression of MFF protein

NCBI chr 9:84,007,798...84,036,039
Ensembl chr 9:84,007,798...84,036,039

G

peroxisome proliferator-activated receptor gamma

multiple interactions

SB 239063 inhibits the reaction [25-hydroxyprotopanaxadiol results in increased phosphorylation of PPARG protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions

SB 239063 inhibits the reaction [25-hydroxyprotopanaxadiol results in increased phosphorylation of PPARGC1A protein]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

sequestosome 1

multiple interactions

[[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

tramadol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

increases expression

Tramadol results in increased expression of ADRA1A protein

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

BCL2 associated X, apoptosis regulator

increases expression

Tramadol results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

decreases activity

Tramadol results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

caspase 3

affects activity
increases expression
multiple interactions
decreases activity

Tramadol affects the activity of CASP3 protein
Tramadol results in increased expression of CASP3 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased activity of CASP3 protein

PMID:27317026 PMID:28499616 PMID:31618080

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases expression
multiple interactions

Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]

PMID:25550769 PMID:31618080

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

creatine kinase B

decreases expression
multiple interactions

Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

PMID:27317026 PMID:33645892

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

creatine kinase, M-type

multiple interactions

Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

cAMP responsive element binding protein 1

increases phosphorylation

tramadol increases phosphorylation of Creb1 protein in Prefrontal Cortex and nucleus accumbens

RGD

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

Tramadol results in decreased activity of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases response to substance
affects methylation
increases metabolic processing
decreases methylation
multiple interactions
affects response to substance
decreases response to substance
affects metabolic processing

CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 protein affects the methylation of Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol

PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More...

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

desmin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of DES protein]

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

dopamine receptor D2

increases expression

Tramadol results in increased expression of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

increases expression

Tramadol results in increased expression of DRD3 protein

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Tramadol increases expression of Fosb protein in Prefrontal Cortex and nucleus accumbens

RGD

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

gap junction protein, alpha 1

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glutamic-oxaloacetic transaminase 1

increases expression
multiple interactions

Tramadol results in increased expression of GOT1 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

increases activity
multiple interactions
increases expression

Tramadol results in increased activity of GPT protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]

PMID:28689766 PMID:31618080

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

5-hydroxytryptamine receptor 2A

multiple interactions
increases activity
increases expression

Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
Tramadol results in increased expression of HTR2A mRNA

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

interferon gamma

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

lactate dehydrogenase A

decreases expression

Tramadol results in decreased expression of LDHA mRNA

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

NADH:ubiquinone oxidoreductase core subunit S1

decreases expression

Tramadol results in decreased expression of NDUFS1 mRNA

NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893

G

opioid receptor, delta 1

affects binding
multiple interactions

Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

multiple interactions
affects binding

[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

multiple interactions
affects binding

[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

pyruvate dehydrogenase kinase 3

increases expression

Tramadol results in increased expression of PDK3 mRNA

NCBI chr X:58,486,699...58,553,533
Ensembl chr X:58,486,554...58,553,557

G

prodynorphin

decreases expression

Tramadol results in decreased expression of PDYN mRNA

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

solute carrier family 2 member 4

multiple interactions

Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 47 member 1

multiple interactions

Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

superoxide dismutase 1

decreases expression
multiple interactions

Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]

PMID:25550769 PMID:31618080

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
decreases expression

Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

multiple interactions
increases expression

Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

tumor necrosis factor

multiple interactions
increases expression

[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]

PMID:17377112 PMID:31618080 PMID:33645892

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

troponin I3, cardiac type

increases expression
multiple interactions

Tramadol results in increased expression of TNNI3 protein
Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

G

vimentin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

venlafaxine hydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression
increases export

Venlafaxine Hydrochloride results in increased expression of ABCB1 mRNA
ABCB1 protein results in increased export of Venlafaxine Hydrochloride

PMID:14550684 PMID:17191263

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

increases expression

Venlafaxine Hydrochloride results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

angiotensin I converting enzyme

increases expression

Venlafaxine Hydrochloride results in increased expression of ACE mRNA

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acid phosphatase 5, tartrate resistant

decreases expression

Venlafaxine Hydrochloride results in decreased expression of ACP5 mRNA

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

actin alpha 2, smooth muscle

multiple interactions

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of ACTA2 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

activin A receptor type 1C

increases expression

Venlafaxine Hydrochloride results in increased expression of ACVR1C mRNA

NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327

G

ADAM metallopeptidase domain 10

increases expression

Venlafaxine Hydrochloride results in increased expression of ADAM10 mRNA

NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889

G

adhesion G protein-coupled receptor L1

affects expression

Venlafaxine Hydrochloride affects the expression of ADGRL1 mRNA

NCBI chr19:24,202,405...24,244,137
Ensembl chr19:24,204,360...24,244,139

G

argonaute RISC catalytic component 2

increases expression

Venlafaxine Hydrochloride results in increased expression of AGO2 mRNA

NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974

G

aryl hydrocarbon receptor

increases expression

Venlafaxine Hydrochloride results in increased expression of AHR mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

A-kinase anchoring protein 5

increases expression

Venlafaxine Hydrochloride results in increased expression of AKAP5 mRNA

NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578

G

AKT serine/threonine kinase 1

increases expression

Venlafaxine Hydrochloride results in increased expression of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions

Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

activated leukocyte cell adhesion molecule

increases expression

Venlafaxine Hydrochloride results in increased expression of ALCAM mRNA

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

ankyrin repeat domain 55

increases expression

Venlafaxine Hydrochloride results in increased expression of ANKRD55 mRNA

NCBI chr 2:43,883,877...43,983,820
Ensembl chr 2:43,883,857...43,983,680

G

adaptor related protein complex 2 subunit beta 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of AP2B1 mRNA

NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013

G

androgen receptor

decreases expression

Venlafaxine Hydrochloride results in decreased expression of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

activity-regulated cytoskeleton-associated protein

increases expression

Venlafaxine Hydrochloride results in increased expression of ARC mRNA; Venlafaxine Hydrochloride results in increased expression of ARC protein

PMID:14580947 PMID:15087240 PMID:15838995

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

ARF GTPase 3

decreases expression

Venlafaxine Hydrochloride results in decreased expression of ARF3 mRNA

NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002

G

Rho GTPase activating protein 10

increases expression

Venlafaxine Hydrochloride results in increased expression of ARHGAP10 mRNA

NCBI chr19:30,448,572...30,710,315
Ensembl chr19:30,448,637...30,710,313

G

Cdc42 guanine nucleotide exchange factor 9

increases expression

Venlafaxine Hydrochloride results in increased expression of ARHGEF9 mRNA

NCBI chr X:59,919,560...60,077,538
Ensembl chr X:59,920,870...60,077,513

G

achaete-scute family bHLH transcription factor 1

decreases expression
increases expression

Venlafaxine Hydrochloride results in decreased expression of ASCL1 mRNA
Venlafaxine Hydrochloride results in increased expression of ASCL1 mRNA

NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993

G

ATPase plasma membrane Ca2+ transporting 3

increases expression

Venlafaxine Hydrochloride results in increased expression of ATP2B3 mRNA

NCBI chr X:151,216,483...151,289,069
Ensembl chr X:151,216,507...151,286,775

G

ATRX, chromatin remodeler

increases expression

Venlafaxine Hydrochloride results in increased expression of ATRX mRNA

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

BCL2 associated X, apoptosis regulator

multiple interactions

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of BAX protein]]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of BAX protein]

PMID:29852128 PMID:35104487

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Venlafaxine Hydrochloride results in decreased expression of BCL2 mRNA
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]

PMID:25423262 PMID:29852128 PMID:35104487

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

increases expression

Venlafaxine Hydrochloride results in increased expression of BDNF mRNA

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

BMP/retinoic acid inducible neural specific 3

increases expression

Venlafaxine Hydrochloride results in increased expression of BRINP3 mRNA

NCBI chr13:58,413,883...58,846,828
Ensembl chr13:58,413,883...58,846,770

G

calcium voltage-gated channel auxiliary subunit beta 4

increases expression

Venlafaxine Hydrochloride results in increased expression of CACNB4 mRNA

NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944

G

calmodulin 3

decreases expression

Venlafaxine Hydrochloride results in decreased expression of CALM3 mRNA

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

G

calcium/calmodulin-dependent protein kinase II alpha

increases expression

Venlafaxine Hydrochloride results in increased expression of CAMK2A mRNA

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calcium/calmodulin-dependent protein kinase II beta

affects expression

Venlafaxine Hydrochloride affects the expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

calcium/calmodulin-dependent protein kinase II gamma

affects expression

Venlafaxine Hydrochloride affects the expression of CAMK2G mRNA

NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050

G

caspase 3

multiple interactions

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of CASP3 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of CASP3 protein]

PMID:29852128 PMID:35104487

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

Nitric Oxide promotes the reaction [Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in decreased activity of CAT protein]

PMID:20305041 PMID:29852128

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cd47 molecule

decreases expression

Venlafaxine Hydrochloride results in decreased expression of CD47 mRNA

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

cadherin 22

affects expression

Venlafaxine Hydrochloride affects the expression of CDH22 mRNA

NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588

G

CUGBP, Elav-like family member 2

increases expression

Venlafaxine Hydrochloride results in increased expression of CELF2 mRNA

NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333

G

chloride nucleotide-sensitive channel 1A

decreases expression

Venlafaxine Hydrochloride results in decreased expression of CLNS1A mRNA

NCBI chr 1:152,019,369...152,039,670
Ensembl chr 1:152,019,378...152,039,661

G

calsyntenin 2

decreases expression

Venlafaxine Hydrochloride results in decreased expression of CLSTN2 mRNA

NCBI chr 8:98,020,406...98,637,232
Ensembl chr 8:98,021,666...98,637,731

G

CCHC-type zinc finger, nucleic acid binding protein

increases expression

Venlafaxine Hydrochloride results in increased expression of CNBP mRNA

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

G

cannabinoid receptor 1

increases expression

Venlafaxine Hydrochloride results in increased expression of CNR1 mRNA

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

contactin 2

increases expression

Venlafaxine Hydrochloride results in increased expression of CNTN2 mRNA

NCBI chr13:43,942,868...43,975,973
Ensembl chr13:43,947,265...43,975,887

G

cytochrome c oxidase copper chaperone COX17

increases expression

Venlafaxine Hydrochloride results in increased expression of COX17 mRNA

NCBI chr11:62,400,733...62,406,507

G

carboxypeptidase D

increases expression

Venlafaxine Hydrochloride results in increased expression of CPD mRNA

NCBI chr10:61,623,528...61,687,491
Ensembl chr10:61,623,526...61,687,491

G

catenin beta 1

increases expression

Venlafaxine Hydrochloride results in increased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

CXXC finger protein 4

increases expression

Venlafaxine Hydrochloride results in increased expression of CXXC4 mRNA

NCBI chr 2:222,664,148...222,689,365
Ensembl chr 2:222,664,771...222,689,365

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions
decreases activity

Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Pregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased hydroxylation of Progesterone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone]; Venlafaxine Hydrochloride inhibits the reaction [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone]
Venlafaxine Hydrochloride results in decreased activity of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects methylation
decreases methylation

CYP2C19 gene polymorphism affects the methylation of Venlafaxine Hydrochloride
CYP2C19 protein results in decreased methylation of Venlafaxine Hydrochloride

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
affects methylation
affects response to substance
decreases methylation
increases metabolic processing
decreases activity

CYP2D6 gene mutant form affects the metabolism of Venlafaxine Hydrochloride; CYP2D6 gene polymorphism affects the metabolism of Venlafaxine Hydrochloride
CYP2D6 gene polymorphism affects the methylation of Venlafaxine Hydrochloride
CYP2D6 protein affects the susceptibility to Venlafaxine Hydrochloride
CYP2D6 protein results in decreased methylation of Venlafaxine Hydrochloride
CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride
Venlafaxine Hydrochloride results in decreased activity of CYP2D6 protein

PMID:10774634 PMID:10877013 PMID:10933885 PMID:15632378 PMID:16044105 More...

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

DAB adaptor protein 2

increases expression

Venlafaxine Hydrochloride results in increased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

dimethylarginine dimethylaminohydrolase 1

increases expression

Venlafaxine Hydrochloride results in increased expression of DDAH1 mRNA

NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339

G

distal membrane arm assembly component 1

increases expression

Venlafaxine Hydrochloride results in increased expression of DMAC1 mRNA

NCBI chr 5:89,241,173...89,243,793
Ensembl chr 5:89,242,661...89,243,757

G

DNA methyltransferase 3 alpha

increases expression

Venlafaxine Hydrochloride results in increased expression of DNMT3A mRNA

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

dipeptidylpeptidase 4

increases expression

Venlafaxine Hydrochloride results in increased expression of DPP4 mRNA

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

endothelin receptor type B

increases expression

Venlafaxine Hydrochloride results in increased expression of EDNRB mRNA

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of ENPP1 mRNA

NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715

G

EPH receptor A5

decreases expression

Venlafaxine Hydrochloride results in decreased expression of EPHA5 mRNA

NCBI chr14:23,653,393...24,020,129
Ensembl chr14:23,653,393...24,017,317

G

formin-like 1

increases expression

Venlafaxine Hydrochloride results in increased expression of FMNL1 mRNA

NCBI chr10:88,115,876...88,143,342
Ensembl chr10:88,116,009...88,143,357

G

gamma-aminobutyric acid type A receptor subunit beta1

increases expression

Venlafaxine Hydrochloride results in increased expression of GABRB1 mRNA

NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948

G

gamma-aminobutyric acid type A receptor subunit beta 2

increases expression

Venlafaxine Hydrochloride results in increased expression of GABRB2 mRNA

NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251

G

glutamate decarboxylase 2

decreases expression

Venlafaxine Hydrochloride results in decreased expression of GAD2 mRNA

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

growth arrest-specific 2

decreases expression

Venlafaxine Hydrochloride results in decreased expression of GAS2 mRNA

NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619

G

growth arrest specific 6

increases expression

Venlafaxine Hydrochloride results in increased expression of GAS6 mRNA

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

guanine deaminase

increases expression

Venlafaxine Hydrochloride results in increased expression of GDA mRNA

NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416

G

glial fibrillary acidic protein

increases expression

Venlafaxine Hydrochloride results in increased expression of GFAP mRNA

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glucagon-like peptide 1 receptor

decreases expression

Venlafaxine Hydrochloride results in decreased expression of GLP1R mRNA

NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241

G

G protein subunit alpha o1

increases expression

Venlafaxine Hydrochloride results in increased expression of GNAO1 mRNA

NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493

G

G protein subunit alpha q

affects expression

Venlafaxine Hydrochloride affects the expression of GNAQ mRNA

NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672

G

glutamate ionotropic receptor AMPA type subunit 1

increases expression

Venlafaxine Hydrochloride results in increased expression of GRIA1 mRNA

NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283

G

glutamate ionotropic receptor AMPA type subunit 3

decreases expression

Venlafaxine Hydrochloride results in decreased expression of GRIA3 mRNA

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

glutamate ionotropic receptor NMDA type subunit 2A

affects expression

Venlafaxine Hydrochloride affects the expression of GRIN2A mRNA

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

affects expression

Venlafaxine Hydrochloride affects the expression of GRIN2B mRNA

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of HCN1 mRNA

NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774

G

histone deacetylase 6

multiple interactions

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of HDAC6 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of HDAC6 protein]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of HDAC6 protein]

NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441

G

hook microtubule-tethering protein 2

increases expression

Venlafaxine Hydrochloride results in increased expression of HOOK2 mRNA

NCBI chr19:23,151,869...23,170,139
Ensembl chr19:23,151,870...23,164,181

G

interleukin 1 receptor accessory protein-like 1

increases expression

Venlafaxine Hydrochloride results in increased expression of IL1RAPL1 mRNA

NCBI chr X:51,371,969...52,876,726
Ensembl chr X:51,378,215...52,876,772

G

potassium voltage-gated channel subfamily C member 2

increases expression

Venlafaxine Hydrochloride results in increased expression of KCNC2 mRNA

NCBI chr 7:47,700,035...47,883,979
Ensembl chr 7:47,700,288...47,883,968

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Venlafaxine Hydrochloride results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium inwardly-rectifying channel, subfamily J, member 3

multiple interactions

Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]

NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124

G

potassium inwardly-rectifying channel, subfamily J, member 5

multiple interactions

Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]

NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518

G

potassium inwardly-rectifying channel, subfamily J, member 6

multiple interactions

Venlafaxine Hydrochloride affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]

NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758

G

potassium two pore domain channel subfamily K member 1

increases expression

Venlafaxine Hydrochloride results in increased expression of KCNK1 mRNA

NCBI chr19:53,959,411...53,997,726
Ensembl chr19:53,959,657...53,997,724

G

kinesin family member 1B

decreases expression

Venlafaxine Hydrochloride results in decreased expression of KIF1B mRNA

NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778

G

kinesin family member 2B

decreases expression

Venlafaxine Hydrochloride results in decreased expression of KIF2B mRNA

NCBI chr10:76,394,160...76,396,379

G

kinesin family member 5A

decreases expression

Venlafaxine Hydrochloride results in decreased expression of KIF5A mRNA

NCBI chr 7:63,051,894...63,089,024
Ensembl chr 7:63,049,424...63,092,858

G

KLF transcription factor 6

increases expression

Venlafaxine Hydrochloride results in increased expression of KLF6 mRNA

NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570

G

kelch-like family member 24

increases expression

Venlafaxine Hydrochloride results in increased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

kallikrein related-peptidase 10

decreases expression

Venlafaxine Hydrochloride results in decreased expression of KLK10 mRNA

NCBI chr 1:94,234,536...94,239,369
Ensembl chr 1:94,235,096...94,239,376

G

LARGE xylosyl- and glucuronyltransferase 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of LARGE1 mRNA

NCBI chr19:11,603,129...12,048,930
Ensembl chr19:11,603,129...12,048,930

G

lipase G, endothelial type

increases expression

Venlafaxine Hydrochloride results in increased expression of LIPG mRNA

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

lectin, mannose-binding, 1

increases expression

Venlafaxine Hydrochloride results in increased expression of LMAN1 mRNA

NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851

G

LIM domain 7

decreases expression

Venlafaxine Hydrochloride results in decreased expression of LMO7 mRNA

NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783

G

lipoprotein lipase

increases expression

Venlafaxine Hydrochloride results in increased expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

membrane associated guanylate kinase, WW and PDZ domain containing 2

increases expression

Venlafaxine Hydrochloride results in increased expression of MAGI2 mRNA

NCBI chr 4:14,386,389...15,870,036
Ensembl chr 4:14,386,399...15,870,240

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased lipidation of MAP1LC3B protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased lipidation of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

microtubule-associated protein 2

increases expression

Venlafaxine Hydrochloride results in increased expression of MAP2 mRNA

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase 1

increases phosphorylation

Venlafaxine Hydrochloride results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

Venlafaxine Hydrochloride results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

decreases expression

Venlafaxine Hydrochloride results in decreased expression of MFNG mRNA

NCBI chr 7:110,310,810...110,328,653
Ensembl chr 7:110,310,812...110,328,653

G

matrix metallopeptidase 9

decreases expression

Venlafaxine Hydrochloride results in decreased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MAGUK p55 scaffold protein 2

increases expression

Venlafaxine Hydrochloride results in increased expression of MPP2 mRNA

NCBI chr10:87,011,434...87,043,883
Ensembl chr10:87,011,434...87,043,896

G

major vault protein

decreases expression

Venlafaxine Hydrochloride results in decreased expression of MVP mRNA

NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380

G

myosin VA

decreases expression

Venlafaxine Hydrochloride results in decreased expression of MYO5A mRNA

NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918

G

nuclear autoantigenic sperm protein

increases expression

Venlafaxine Hydrochloride results in increased expression of NASP mRNA

NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928

G

neuronal growth regulator 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of NEGR1 mRNA

NCBI chr 2:245,624,460...246,359,605
Ensembl chr 2:245,624,435...246,356,730

G

neural EGFL like 2

increases expression

Venlafaxine Hydrochloride results in increased expression of NELL2 mRNA

NCBI chr 7:126,343,089...126,662,903
Ensembl chr 7:126,198,851...126,733,503

G

neuronal differentiation 1

increases expression

Venlafaxine Hydrochloride results in increased expression of NEUROD1 mRNA

NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649

G

nuclear factor I X

increases expression

Venlafaxine Hydrochloride results in increased expression of NFIX mRNA

NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265

G

neuronal pentraxin receptor

decreases expression

Venlafaxine Hydrochloride results in decreased expression of NPTXR mRNA

NCBI chr 7:111,336,660...111,354,737
Ensembl chr 7:111,336,664...111,354,802

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 3, group C, member 2

decreases expression

Venlafaxine Hydrochloride results in decreased expression of NR3C2 mRNA

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

NOP2/Sun RNA methyltransferase 2

decreases expression

Venlafaxine Hydrochloride results in decreased expression of NSUN2 mRNA

NCBI chr 1:33,662,139...33,685,887
Ensembl chr 1:33,662,139...33,685,862

G

neurotrophic receptor tyrosine kinase 2

decreases expression

Venlafaxine Hydrochloride results in decreased expression of NTRK2 mRNA

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

neurotrophic receptor tyrosine kinase 3

decreases expression

Venlafaxine Hydrochloride results in decreased expression of NTRK3 mRNA

NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286

G

PDGFA associated protein 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of PDAP1 mRNA

NCBI chr12:9,470,652...9,480,880
Ensembl chr12:9,470,574...9,535,374

G

phosphodiesterase 4B

increases expression

Venlafaxine Hydrochloride results in increased expression of PDE4B mRNA

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

phosphodiesterase 4D

increases expression

Venlafaxine Hydrochloride results in increased expression of PDE4D mRNA

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

G

protein disulfide isomerase family A, member 3

decreases expression

Venlafaxine Hydrochloride results in decreased expression of PDIA3 mRNA

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

G

3-phosphoinositide dependent protein kinase-1

affects expression

Venlafaxine Hydrochloride affects the expression of PDPK1 mRNA

NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623

G

peroxisomal biogenesis factor 2

affects expression

Venlafaxine Hydrochloride affects the expression of PEX2 mRNA

NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404

G

progesterone receptor membrane component 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of PGRMC1 mRNA

NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682

G

Pim-3 proto-oncogene, serine/threonine kinase

decreases expression

Venlafaxine Hydrochloride results in decreased expression of PIM3 mRNA

NCBI chr 7:119,953,377...119,956,587
Ensembl chr 7:119,953,175...119,956,587

G

POU class 3 homeobox 2

increases expression

Venlafaxine Hydrochloride results in increased expression of POU3F2 mRNA

NCBI chr 5:36,077,930...36,083,838
Ensembl chr 5:36,077,930...36,083,838

G

protein phosphatase 1 catalytic subunit alpha

increases expression

Venlafaxine Hydrochloride results in increased expression of PPP1CA mRNA

NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327

G

protein phosphatase 1, regulatory subunit 3A

increases expression

Venlafaxine Hydrochloride results in increased expression of PPP1R3A mRNA

NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638

G

protein phosphatase 1, regulatory subunit 9B

decreases expression

Venlafaxine Hydrochloride results in decreased expression of PPP1R9B mRNA

NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083

G

protein phosphatase 3, regulatory subunit B, alpha

decreases expression

Venlafaxine Hydrochloride results in decreased expression of PPP3R1 mRNA

NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907

G

proline-rich acidic protein 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of PRAP1 mRNA

NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872

G

peroxiredoxin 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of PRDX1 mRNA

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

decreases expression

Venlafaxine Hydrochloride results in decreased expression of PREX2 mRNA

NCBI chr 5:7,937,692...8,253,112
Ensembl chr 5:7,942,573...8,253,068

G

protein kinase C, epsilon

increases expression

Venlafaxine Hydrochloride results in increased expression of PRKCE mRNA

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

protein kinase cGMP-dependent 2

increases expression

Venlafaxine Hydrochloride results in increased expression of PRKG2 mRNA

NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of PRKN protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of PRKN protein]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prolactin

increases expression

Venlafaxine Hydrochloride results in increased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

peptide YY

increases expression

Venlafaxine Hydrochloride results in increased expression of PYY mRNA

NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815

G

RAB14, member RAS oncogene family

increases expression

Venlafaxine Hydrochloride results in increased expression of RAB14 mRNA

NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172

G

RAB4B, member RAS oncogene family

increases expression

Venlafaxine Hydrochloride results in increased expression of RAB4B mRNA

NCBI chr 1:82,461,396...82,472,784
Ensembl chr 1:82,461,396...82,472,763

G

regulator of chromosome condensation 1

increases expression

Venlafaxine Hydrochloride results in increased expression of RCC1 mRNA

NCBI chr 5:144,526,025...144,544,445
Ensembl chr 5:144,526,025...144,544,577

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

regulating synaptic membrane exocytosis 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of RIMS1 mRNA

NCBI chr 9:24,696,959...25,196,404
Ensembl chr 9:24,698,854...25,196,631

G

ring finger protein 1

increases expression

Venlafaxine Hydrochloride results in increased expression of RING1 mRNA

NCBI chr20:4,830,120...4,833,623
Ensembl chr20:4,830,053...4,833,620

G

rabphilin 3A

decreases expression

Venlafaxine Hydrochloride results in decreased expression of RPH3A mRNA

NCBI chr12:35,542,389...35,618,901
Ensembl chr12:35,542,728...35,617,592

G

spalt-like transcription factor 1

increases expression

Venlafaxine Hydrochloride results in increased expression of SALL1 mRNA

NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705

G

serpin family I member 1

increases expression

Venlafaxine Hydrochloride results in increased expression of SERPINI1 mRNA

NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135

G

small glutamine rich tetratricopeptide repeat co-chaperone beta

increases expression

Venlafaxine Hydrochloride results in increased expression of SGTB mRNA

NCBI chr 2:35,233,045...35,269,527
Ensembl chr 2:35,233,042...35,269,518

G

SH3 and multiple ankyrin repeat domains 2

increases expression

Venlafaxine Hydrochloride results in increased expression of SHANK2 mRNA

NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394

G

signal-induced proliferation-associated 1 like 1

increases expression

Venlafaxine Hydrochloride results in increased expression of SIPA1L1 mRNA

NCBI chr 6:101,839,351...102,118,408
Ensembl chr 6:101,839,404...102,116,950

G

solute carrier family 26 member 3

increases expression

Venlafaxine Hydrochloride results in increased expression of SLC26A3 mRNA

NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772

G

solute carrier family 2 member 4

decreases expression

Venlafaxine Hydrochloride results in decreased expression of SLC2A4 mRNA

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 4 member 4

increases expression

Venlafaxine Hydrochloride results in increased expression of SLC4A4 mRNA

NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883

G

solute carrier family 5 member 1

increases expression

Venlafaxine Hydrochloride results in increased expression of SLC5A1 mRNA

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

solute carrier family 6 member 4

affects response to substance

SLC6A4 gene polymorphism affects the susceptibility to Venlafaxine Hydrochloride

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

solute carrier family 6 member 6

increases expression

Venlafaxine Hydrochloride results in increased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

superoxide dismutase 1

increases expression

Venlafaxine Hydrochloride results in increased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

sialophorin

increases expression

Venlafaxine Hydrochloride results in increased expression of SPN mRNA

NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628

G

sequestosome 1

decreases expression
multiple interactions

Venlafaxine Hydrochloride results in decreased expression of SQSTM1 mRNA
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of SQSTM1 protein]]; Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of SQSTM1 protein]

PMID:25423262 PMID:35104487

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

staufen double-stranded RNA binding protein 2

increases expression

Venlafaxine Hydrochloride results in increased expression of STAU2 mRNA

NCBI chr 5:2,840,741...3,084,935
Ensembl chr 5:2,840,765...3,084,929

G

serine threonine kinase 39

increases expression

Venlafaxine Hydrochloride results in increased expression of STK39 mRNA

NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060

G

synaptic vesicle glycoprotein 2b

affects expression

Venlafaxine Hydrochloride affects the expression of SV2B mRNA

NCBI chr 1:128,978,471...129,152,479
Ensembl chr 1:128,978,473...129,152,479

G

synapsin II

decreases expression

Venlafaxine Hydrochloride results in decreased expression of SYN2 mRNA

NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192

G

synaptojanin 2

affects expression

Venlafaxine Hydrochloride affects the expression of SYNJ2 mRNA

NCBI chr 1:46,518,594...46,621,919
Ensembl chr 1:46,518,709...46,633,687

G

synaptophysin

increases expression

Venlafaxine Hydrochloride results in increased expression of SYP mRNA

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

synaptotagmin 4

increases expression

Venlafaxine Hydrochloride results in increased expression of SYT4 mRNA

NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332

G

tachykinin receptor 3

increases expression

Venlafaxine Hydrochloride results in increased expression of TACR3 mRNA

NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791

G

transcription factor 12

decreases expression

Venlafaxine Hydrochloride results in decreased expression of TCF12 mRNA

NCBI chr 8:72,490,447...72,799,265
Ensembl chr 8:72,492,567...72,799,201

G

transcription factor 4

increases expression

Venlafaxine Hydrochloride results in increased expression of TCF4 mRNA

NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425

G

thrombomodulin

decreases expression

Venlafaxine Hydrochloride results in decreased expression of THBD mRNA

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

tumor protein p53

multiple interactions

Venlafaxine Hydrochloride inhibits the reaction [Cisplatin results in increased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tripartite motif-containing 13

decreases expression

Venlafaxine Hydrochloride results in decreased expression of TRIM13 mRNA

NCBI chr15:35,733,548...35,772,676
Ensembl chr15:35,734,107...35,772,677

G

thyroid stimulating hormone receptor

increases expression

Venlafaxine Hydrochloride results in increased expression of TSHR mRNA

NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538

G

thioredoxin 2

decreases expression

Venlafaxine Hydrochloride results in decreased expression of TXN2 mRNA

NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359

G

ubiquitin conjugating enzyme E2 Q1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of UBE2Q1 mRNA

NCBI chr 2:175,198,793...175,209,152
Ensembl chr 2:175,198,873...175,207,942

G

uncoupling protein 3

decreases expression

Venlafaxine Hydrochloride results in decreased expression of UCP3 mRNA

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

G

unc-13 homolog B

decreases expression

Venlafaxine Hydrochloride results in decreased expression of UNC13B mRNA

NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926

G

vesicle-associated membrane protein 1

decreases expression

Venlafaxine Hydrochloride results in decreased expression of VAMP1 mRNA

NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349

G

valosin containing protein interacting protein 1

increases expression

Venlafaxine Hydrochloride results in increased expression of VCPIP1 mRNA

NCBI chr 5:9,534,247...9,560,889
Ensembl chr 5:9,534,129...9,562,040

G

voltage-dependent anion channel 1

increases expression

Venlafaxine Hydrochloride results in increased expression of VDAC1 mRNA

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

vascular endothelial growth factor B

decreases expression

Venlafaxine Hydrochloride results in decreased expression of VEGFB mRNA

NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944

G

WD repeat and FYVE domain containing 1

increases expression

Venlafaxine Hydrochloride results in increased expression of WDFY1 mRNA

NCBI chr 9:81,034,852...81,092,823
Ensembl chr 9:81,034,849...81,092,775

G

zinc finger protein 24

increases expression

Venlafaxine Hydrochloride results in increased expression of ZFP24 mRNA

NCBI chr18:15,295,687...15,307,319
Ensembl chr18:15,298,290...15,306,799

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19898
chemical entity	19896
molecular entity	19896
polyatomic entity	19848
heteroatomic molecular entity	19806
hydroxides	19365
organic hydroxy compound	18978
alcohol	15732
cyclohexanols	235
(1R,3R)-5-(hydroxymethyl)cyclohexane-1,2,3-triol	0
(1S,2S,5S)-2-(4-glutaridylbenzyl)-5-phenylcyclohexan-1-ol	0
(4E, 8E)-N-2-hydroxyhexadecanoyl-1-O-beta-glucopyranosyl-9-methyl-C18-sphinga-4,8-dienine	0
1-Cyclopropyl-4-methyl-1,3-cyclohexanediol	0
2,4-dimethyl-Cyclohexanol	0
2-Deoxystreptamine phosphate	0
2-aminocyclohexan-1-ol(1+)	0
2-hydroxy-2-phenylcyclohexanecarboxylic acid +	0
2-hydroxy-3,6-diphenylcyclohexyl acetate	0
3,3,5-trimethylcyclohexanol +	0
3,4-Dimethylcyclohexanol	0
3,5-Dimethylcyclohexanol	0
3,6-Diphenylcyclohexan-1,2-diol	0
3-Methylcyclohexanol	0
4-[1-Cyclohexyl-2-(2-piperidinyl)ethyl]cyclohexanol	0
5-epi-Valiolol 7-phosphate	0
Ampelomin C	0
Ampelomin D	0
Ampelomin E	0
Ampelomin F	0
Arthpyrone E	0
Brasilamide F	0
Brasilamide I	0
Brasilamide J	0
Citrantifidiol	0
D-4-O-Methyl-myo-inositol	0
Dambonitol	0
Dendrodochol B	0
Dendrodochol C	0
Deoxyvalidamine	0
Dothideomycetone A	0
GSK046	0
Iso-enacyloxin IIa	0
L-Quebrachitol	0
Mytilitol	0
N,N-didesmethylvenlafaxine	0
N,O-didesmethylvenlafaxine	0
N,O-didesmethylvenlafaxine-glucuronide	0
N-desmethylvenlafaxine	0
O-Methyl-scyllo-inositol	0
O-desmethylvenlafaxine	0
Phomaketide A	0
Phomaketide B	0
Polisin C	0
Rengyol	0
SB-239063	24
Speciosin H	0
Speciosin I	0
Speciosin J	0
Speciosin Q	0
Speciosin R	0
Speciosin S	0
Stagonosporyne A	0
Stagonosporyne B	0
Stagonosporyne C	0
Waikialide B	0
beta-2,3,4,5,6-Pentachlorocyclohexanol	0
beta-2,3,5,6-Tetrachloro-1,4-cyclohexanediol	0
cethexonium	0
ciramadol	0
cis-5-caffeoyl-quinic acid	0
cyclohexanol +	38
grasshopper ketone	0
rociverine	0
trans-4-Phenyl-4-piperidinocyclohexanol	0
venlafaxine +	182
Path 2
Term	Annotations
CHEBI ontology	19898
subatomic particle	19896
composite particle	19896
hadron	19896
baryon	19896
nucleon	19896
atomic nucleus	19896
atom	19896
main group element atom	19835
p-block element atom	19835
p-block molecular entity	19835
chalcogen molecular entity	19586
oxygen molecular entity	19558
hydroxides	19365
organic hydroxy compound	18978
alcohol	15732
cyclohexanols	235
(1R,3R)-5-(hydroxymethyl)cyclohexane-1,2,3-triol	0
(1S,2S,5S)-2-(4-glutaridylbenzyl)-5-phenylcyclohexan-1-ol	0
(4E, 8E)-N-2-hydroxyhexadecanoyl-1-O-beta-glucopyranosyl-9-methyl-C18-sphinga-4,8-dienine	0
1-Cyclopropyl-4-methyl-1,3-cyclohexanediol	0
2,4-dimethyl-Cyclohexanol	0
2-Deoxystreptamine phosphate	0
2-aminocyclohexan-1-ol(1+)	0
2-hydroxy-2-phenylcyclohexanecarboxylic acid +	0
2-hydroxy-3,6-diphenylcyclohexyl acetate	0
3,3,5-trimethylcyclohexanol +	0
3,4-Dimethylcyclohexanol	0
3,5-Dimethylcyclohexanol	0
3,6-Diphenylcyclohexan-1,2-diol	0
3-Methylcyclohexanol	0
4-[1-Cyclohexyl-2-(2-piperidinyl)ethyl]cyclohexanol	0
5-epi-Valiolol 7-phosphate	0
Ampelomin C	0
Ampelomin D	0
Ampelomin E	0
Ampelomin F	0
Arthpyrone E	0
Brasilamide F	0
Brasilamide I	0
Brasilamide J	0
Citrantifidiol	0
D-4-O-Methyl-myo-inositol	0
Dambonitol	0
Dendrodochol B	0
Dendrodochol C	0
Deoxyvalidamine	0
Dothideomycetone A	0
GSK046	0
Iso-enacyloxin IIa	0
L-Quebrachitol	0
Mytilitol	0
N,N-didesmethylvenlafaxine	0
N,O-didesmethylvenlafaxine	0
N,O-didesmethylvenlafaxine-glucuronide	0
N-desmethylvenlafaxine	0
O-Methyl-scyllo-inositol	0
O-desmethylvenlafaxine	0
Phomaketide A	0
Phomaketide B	0
Polisin C	0
Rengyol	0
SB-239063	24
Speciosin H	0
Speciosin I	0
Speciosin J	0
Speciosin Q	0
Speciosin R	0
Speciosin S	0
Stagonosporyne A	0
Stagonosporyne B	0
Stagonosporyne C	0
Waikialide B	0
beta-2,3,4,5,6-Pentachlorocyclohexanol	0
beta-2,3,5,6-Tetrachloro-1,4-cyclohexanediol	0
cethexonium	0
ciramadol	0
cis-5-caffeoyl-quinic acid	0
cyclohexanol +	38
grasshopper ketone	0
rociverine	0
trans-4-Phenyl-4-piperidinocyclohexanol	0
venlafaxine +	182

paths to the root