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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gardiquimod
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Accession:CHEBI:234430 term browser browse the term
Definition:An imidazoquinoline that is 1H-imidazo[4,5-c]quinoline substituted by 2-hydroxy-2-methylpropyl, (ethylamino)methyl, and amino groups at positions 1, 2, and 4, respectively. It is an agonist of toll-like receptor 7.
Synonyms:related_synonym: 1-(4-amino-2-ethylaminomethylimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol;   1-{4-amino-2-[(ethylamino)methyl]-1H-imidazo[4,5-c]quinolin-1-yl}-2-methylpropan-2-ol;   4-amino-2-[(ethylamino)methyl]-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol
 xref: CAS:1020412-43-4;   HMDB:HMDB0252643
 xref_mesh: MESH:C546771
 xref: pdb-ccd:9K3;   pubmed:18439678;   pubmed:20481492;   pubmed:20543857;   pubmed:23316755;   pubmed:23867290;   pubmed:24057248;   pubmed:26718740;   pubmed:28036266;   pubmed:28422377;   pubmed:31709434;   pubmed:32592404;   pubmed:32838525;   pubmed:33354779;   pubmed:34052416;   pubmed:34089789;   pubmed:34177915;   pubmed:34205464;   pubmed:34678647;   pubmed:35452465;   pubmed:35806163;   pubmed:36535979;   pubmed:37149573;   pubmed:37954494;   pubmed:39021304;   pubmed:40352938;   pubmed:40383023;   wikipedia.en:Gardiquimod
 chemrof_formula: C17H23N5O
 chemrof_smiles: CCNCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
 chemrof_inchikey: FHJATBIERQTCTN-UHFFFAOYSA-N
 chemrof_inchi: InChI=1S/C17H23N5O/c1-4-19-9-13-21-14-15(22(13)10-17(2,3)23)11-7-5-6-8-12(11)20-16(14)18/h5-8,19,23H,4,9-10H2,1-3H3,(H2,18,20)


show annotations for term's descendants           Sort by:
gardiquimod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ACSL1 mRNA] CTD PMID:28003376 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ADAM17 mRNA] CTD PMID:28003376 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Adk adenosine kinase multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of ADK mRNA] CTD PMID:28003376 NCBI chr15:2,912,543...3,295,745
Ensembl chr15:2,912,544...3,295,745 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ALCAM mRNA] CTD PMID:28003376 NCBI chr11:61,804,932...62,005,250
Ensembl chr11:61,805,049...62,006,876 		JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ANGPTL4 mRNA] CTD PMID:28003376 NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681 		JBrowse link
G Ankrd22 ankyrin repeat domain 22 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of ANKRD22 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ANKRD22 mRNA] 		CTD PMID:28003376 NCBI chr 1:241,052,235...241,083,737
Ensembl chr 1:241,052,237...241,105,559 		JBrowse link
G Arhgap24 Rho GTPase activating protein 24 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ARHGAP24 mRNA] CTD PMID:28003376 NCBI chr14:7,105,200...7,488,437
Ensembl chr14:7,105,200...7,528,950 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of ASAH1 mRNA] CTD PMID:28003376 NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305 		JBrowse link
G Asgr2 asialoglycoprotein receptor 2 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of ASGR2 mRNA] CTD PMID:28003376 NCBI chr10:55,320,082...55,333,294
Ensembl chr10:55,320,091...55,333,263 		JBrowse link
G Batf basic leucine zipper ATF-like transcription factor increases expression
multiple interactions 		ISO gardiquimod results in increased expression of BATF mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of BATF mRNA] 		CTD PMID:28003376 NCBI chr 6:111,084,717...111,107,052
Ensembl chr 6:111,084,717...111,107,052 		JBrowse link
G Bcap29 B-cell receptor-associated protein 29 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of BCAP29 mRNA] CTD PMID:28003376 NCBI chr 6:53,910,209...53,950,206
Ensembl chr 6:53,910,216...53,949,963 		JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of BCL2A1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of BCL2A1 mRNA] 		CTD PMID:28003376 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of BCL2L11 mRNA] CTD PMID:28003376 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Bcl2l14 Bcl2-like 14 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of BCL2L14 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of BCL2L14 mRNA] 		CTD PMID:28003376 NCBI chr 4:168,948,919...168,989,450
Ensembl chr 4:168,948,946...168,990,079 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CCR2 mRNA] CTD PMID:28003376 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of CCR5 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CCR5 mRNA] 		CTD PMID:28003376 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594 		JBrowse link
G Cd274 CD274 molecule increases expression
multiple interactions 		ISO gardiquimod results in increased expression of CD274 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD274 mRNA] 		CTD PMID:28003376 NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951 		JBrowse link
G Cd300lf Cd300 molecule-like family member F multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CD300LF mRNA] CTD PMID:28003376 NCBI chr10:100,858,924...100,875,111
Ensembl chr10:100,858,924...100,875,022 		JBrowse link
G Cd38 CD38 molecule increases expression
multiple interactions 		ISO gardiquimod results in increased expression of CD38 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD38 mRNA] 		CTD PMID:28003376 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505 		JBrowse link
G Cd40 CD40 molecule multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD40 mRNA] CTD PMID:28003376 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd79a CD79a molecule decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of CD79A mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CD79A mRNA] 		CTD PMID:28003376 NCBI chr 1:89,621,460...89,625,813
Ensembl chr 1:89,621,460...89,625,812 		JBrowse link
G Cd79b CD79b molecule multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CD79B mRNA] CTD PMID:28003376 NCBI chr10:91,739,134...91,742,312
Ensembl chr10:91,739,137...91,742,405 		JBrowse link
G Cd80 Cd80 molecule multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD80 mRNA] CTD PMID:28003376 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540 		JBrowse link
G Cd9 CD9 molecule decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of CD9 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CD9 mRNA] 		CTD PMID:28003376 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:159,942,560...159,975,444 		JBrowse link
G Cd93 CD93 molecule multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CD93 mRNA] CTD PMID:28003376 NCBI chr 3:156,345,019...156,351,537
Ensembl chr 3:156,345,019...156,351,537 		JBrowse link
G Cda cytidine deaminase multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CDA mRNA] CTD PMID:28003376 NCBI chr 5:155,839,929...155,866,541
Ensembl chr 5:155,839,929...155,866,541 		JBrowse link
G Ces1d carboxylesterase 1D increases expression
multiple interactions 		ISO gardiquimod results in increased expression of CES1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CES1 mRNA] 		CTD PMID:28003376 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Cfb complement factor B multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CFB mRNA] CTD PMID:28003376 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740 		JBrowse link
G Cfl2 cofilin 2 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CFL2 mRNA] CTD PMID:28003376 NCBI chr 6:78,090,843...78,094,888
Ensembl chr 6:78,090,843...78,094,888 		JBrowse link
G Clec10a C-type lectin domain containing 10A multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CLEC10A mRNA] CTD PMID:28003376 NCBI chr10:55,374,914...55,379,110
Ensembl chr10:55,374,887...55,379,108 		JBrowse link
G Clec7a C-type lectin domain containing 7A decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of CLEC7A mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CLEC7A mRNA] 		CTD PMID:28003376 NCBI chr 4:164,588,737...164,599,953
Ensembl chr 4:164,588,754...164,599,919 		JBrowse link
G Cmah cytidine monophospho-N-acetylneuraminic acid hydroxylase multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CMAH mRNA] CTD PMID:28003376 NCBI chr17:40,985,129...41,070,317
Ensembl chr17:41,011,641...41,070,252 		JBrowse link
G Cmtm8 CKLF-like MARVEL transmembrane domain containing 8 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CMTM8 mRNA] CTD PMID:28003376 NCBI chr 8:123,360,168...123,425,291
Ensembl chr 8:123,360,170...123,425,276 		JBrowse link
G Cpd carboxypeptidase D multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CPD mRNA] CTD PMID:28003376 NCBI chr10:62,121,681...62,185,638
Ensembl chr10:62,121,679...62,185,638 		JBrowse link
G Cpm carboxypeptidase M increases expression
multiple interactions 		ISO gardiquimod results in increased expression of CPM mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CPM mRNA] 		CTD PMID:28003376 NCBI chr 7:55,111,599...55,172,114
Ensembl chr 7:55,111,599...55,172,114 		JBrowse link
G Cr2 complement C3d receptor 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of CR2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CR2 mRNA] 		CTD PMID:28003376 NCBI chr13:109,207,034...109,244,980
Ensembl chr13:109,213,867...109,244,552 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
increases expression 		ISO bafilomycin A1 inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein]; Phosphorothioate Oligonucleotides inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein] CTD PMID:26682054 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of CYP1B1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CYP1B1 mRNA] 		CTD PMID:28003376 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Dnaaf1 dynein, axonemal, assembly factor 1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of DNAAF1 mRNA] CTD PMID:28003376 NCBI chr19:64,532,859...64,560,942
Ensembl chr19:64,532,860...64,561,435 		JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of DNASE1L1 mRNA] CTD PMID:28003376 NCBI chr  X:157,208,230...157,216,812
Ensembl chr  X:157,208,230...157,216,711 		JBrowse link
G Ebi3 Epstein-Barr virus induced 3 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of EBI3 mRNA] CTD PMID:28003376 NCBI chr 9:861,441...874,731
Ensembl chr 9:870,792...874,973 		JBrowse link
G Eeig2 EEIG family member 2 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of EEIG2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of EEIG2 mRNA] 		CTD PMID:28003376 NCBI chr 2:199,296,582...199,351,449
Ensembl chr 2:199,296,582...199,351,449 		JBrowse link
G Ehd1 EH-domain containing 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of EHD1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of EHD1 mRNA] 		CTD PMID:28003376 NCBI chr 1:213,009,113...213,031,488
Ensembl chr 1:213,008,049...213,031,485 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of ENPP2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ENPP2 mRNA] 		CTD PMID:28003376 NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957 		JBrowse link
G Epha4 Eph receptor A4 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of EPHA4 mRNA] CTD PMID:28003376 NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755 		JBrowse link
G Epop elongin BC and polycomb repressive complex 2 associated protein multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of EPOP mRNA] CTD PMID:28003376 NCBI chr10:83,120,767...83,122,287
Ensembl chr10:83,119,970...83,122,423 		JBrowse link
G Ereg epiregulin multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of EREG mRNA] CTD PMID:28003376 NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260 		JBrowse link
G Etv3 ETS variant transcription factor 3 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ETV3 mRNA] CTD PMID:28003376 NCBI chr 2:175,263,389...175,278,217
Ensembl chr 2:175,263,459...175,278,208 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of EXT1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of EXT1 mRNA] 		CTD PMID:28003376 NCBI chr 7:86,265,651...86,544,488
Ensembl chr 7:86,259,900...86,544,567 		JBrowse link
G Fabp5 fatty acid binding protein 5 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FABP5 mRNA] CTD PMID:28003376 NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:93,672,458...93,676,127 		JBrowse link
G Fcar Fc alpha receptor decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of FCAR mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of FCAR mRNA] 		CTD PMID:28003376 NCBI chr 1:78,669,119...78,703,223 JBrowse link
G Ffar2 free fatty acid receptor 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of FFAR2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FFAR2 mRNA] 		CTD PMID:28003376 NCBI chr 1:95,199,277...95,202,599
Ensembl chr 1:95,199,271...95,202,623 		JBrowse link
G Ffar3 free fatty acid receptor 3 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FFAR3 mRNA] CTD PMID:28003376 NCBI chr 1:95,232,804...95,234,144
Ensembl chr 1:95,232,336...95,234,354 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FLT1 mRNA] CTD PMID:28003376 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750 		JBrowse link
G Flvcr2 FLVCR choline and putative heme transporter 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of FLVCR2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FLVCR2 mRNA] 		CTD PMID:28003376 NCBI chr 6:111,139,352...111,203,345
Ensembl chr 6:111,139,295...111,203,345 		JBrowse link
G Fpr2 formyl peptide receptor 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of FPR2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FPR2 mRNA] 		CTD PMID:28003376 NCBI chr 1:67,449,637...67,458,272
Ensembl chr 1:67,449,637...67,458,272 		JBrowse link
G Frmd3 FERM domain containing 3 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FRMD3 mRNA] CTD PMID:28003376 NCBI chr 5:92,810,989...93,077,326
Ensembl chr 5:92,810,736...93,077,325 		JBrowse link
G Fuca1 alpha-L-fucosidase 1 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of FUCA1 mRNA] CTD PMID:28003376 NCBI chr 5:153,436,262...153,453,512
Ensembl chr 5:153,436,248...153,453,511 		JBrowse link
G Fxyd6 FXYD domain-containing ion transport regulator 6 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of FXYD6 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FXYD6 mRNA] 		CTD PMID:28003376 NCBI chr 8:54,575,578...54,602,715
Ensembl chr 8:54,575,591...54,602,715 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression
multiple interactions 		ISO gardiquimod results in increased expression of GADD45B mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of GADD45B mRNA] 		CTD PMID:28003376 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718 		JBrowse link
G Gapt Grb2-binding adaptor protein, transmembrane decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of GAPT mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of GAPT mRNA] 		CTD PMID:28003376 NCBI chr 2:43,660,900...43,665,485
Ensembl chr 2:43,660,900...43,665,448 		JBrowse link
G Gas7 growth arrest specific 7 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of GAS7 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of GAS7 mRNA] 		CTD PMID:28003376 NCBI chr10:52,651,690...52,882,244
Ensembl chr10:52,651,690...52,882,244 		JBrowse link
G Gcsam germinal center-associated, signaling and motility increases expression
multiple interactions 		ISO gardiquimod results in increased expression of GCSAM mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of GCSAM mRNA] 		CTD PMID:28003376 NCBI chr11:68,658,350...68,669,598
Ensembl chr11:68,660,438...68,669,584 		JBrowse link
G Gng7 G protein subunit gamma 7 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of GNG7 mRNA] CTD PMID:28003376 NCBI chr 7:9,348,148...9,411,924
Ensembl chr 7:9,348,218...9,411,923 		JBrowse link
G Gpr137b G protein-coupled receptor 137B multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of GPR137B mRNA] CTD PMID:28003376 NCBI chr17:92,987,792...93,026,003
Ensembl chr17:92,942,559...93,025,911 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of GRK2 mRNA] CTD PMID:28003376 NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:211,009,978...211,031,015 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of HAMP mRNA] CTD PMID:28003376 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297 		JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of HCAR2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of HCAR2 mRNA] 		CTD PMID:28003376 NCBI chr12:38,387,163...38,389,149
Ensembl chr12:38,387,230...38,389,391 		JBrowse link
G Hebp1 heme binding protein 1 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of HEBP1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of HEBP1 mRNA] 		CTD PMID:28003376 NCBI chr 4:169,705,665...169,735,199
Ensembl chr 4:169,705,668...169,735,199 		JBrowse link
G Heg1 heart development protein with EGF-like domains 1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of HEG1 mRNA] CTD PMID:28003376 NCBI chr11:80,512,096...80,600,150
Ensembl chr11:80,512,096...80,600,092 		JBrowse link
G Hlx H2.0-like homeobox multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of HLX mRNA] CTD PMID:28003376 NCBI chr13:98,811,852...98,817,264
Ensembl chr13:98,811,856...98,817,264 		JBrowse link
G Hycc1 hyccin PI4KA lipid kinase complex subunit 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of HYCC1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of HYCC1 mRNA] 		CTD PMID:28003376 NCBI chr 4:12,024,692...12,131,504
Ensembl chr 4:12,024,739...12,131,501 		JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IFI27 mRNA] CTD PMID:28003376 NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781 		JBrowse link
G Ifna1 interferon, alpha 1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IFNA1 mRNA] CTD PMID:28003376 NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IFNG mRNA] CTD PMID:28003376 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ifnlr1 interferon, lambda receptor 1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IFNLR1 mRNA] CTD PMID:28003376 NCBI chr 5:153,203,597...153,225,911
Ensembl chr 5:153,203,597...153,225,911 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of IKZF1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IKZF1 mRNA] 		CTD PMID:28003376 NCBI chr14:90,468,696...90,556,522
Ensembl chr14:90,469,172...90,557,574 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of IL10 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IL10 mRNA] 		CTD PMID:28003376 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IL12B mRNA] CTD PMID:28003376 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of IL13RA1 mRNA] CTD PMID:28003376 NCBI chr  X:120,213,670...120,294,777
Ensembl chr  X:120,214,075...120,274,461 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion 		ISO gardiquimod results in increased expression of IL6 mRNA; gardiquimod results in increased expression of IL6 protein
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IL6 mRNA]; Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IL6 protein]
gardiquimod results in increased secretion of IL6 protein
LGMN gene mutant form inhibits the reaction [gardiquimod results in increased secretion of IL6 protein]; Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IL6 protein] 		CTD PMID:22916010 PMID:28003376 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irf8 interferon regulatory factor 8 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IRF8 mRNA] CTD PMID:28003376 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:65,699,284...65,721,062 		JBrowse link
G Itgax integrin subunit alpha X decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of ITGAX mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of ITGAX mRNA] 		CTD PMID:28003376 NCBI chr 1:192,140,089...192,171,151
Ensembl chr 1:192,149,905...192,171,151 		JBrowse link
G Itpkc inositol-trisphosphate 3-kinase C increases expression
multiple interactions 		ISO gardiquimod results in increased expression of ITPKC mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ITPKC mRNA] 		CTD PMID:28003376 NCBI chr 1:91,628,606...91,650,182
Ensembl chr 1:91,628,608...91,653,350 		JBrowse link
G Jaml junction adhesion molecule like multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of JAML mRNA] CTD PMID:28003376 NCBI chr 8:54,281,596...54,313,655
Ensembl chr 8:54,281,644...54,313,500 		JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of KCNE3 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of KCNE3 mRNA] 		CTD PMID:28003376 NCBI chr 1:163,936,035...163,942,998
Ensembl chr 1:163,935,991...163,950,162 		JBrowse link
G Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of KCNJ15 mRNA] CTD PMID:28003376 NCBI chr11:48,046,953...48,091,285
Ensembl chr11:48,035,655...48,092,457 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of KCNN4 mRNA] CTD PMID:28003376 NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:89,086,814...89,102,275 		JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of KCTD12 mRNA] CTD PMID:28003376 NCBI chr15:86,214,786...86,220,725
Ensembl chr15:86,214,840...86,224,539 		JBrowse link
G L3mbtl3 L3MBTL histone methyl-lysine binding protein 3 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of L3MBTL3 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of L3MBTL3 mRNA] 		CTD PMID:28003376 NCBI chr 1:20,807,679...20,908,609
Ensembl chr 1:20,808,973...20,908,608 		JBrowse link
G Lag3 lymphocyte activating 3 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of LAG3 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LAG3 mRNA] 		CTD PMID:28003376 NCBI chr 4:159,398,930...159,407,001
Ensembl chr 4:159,398,932...159,406,669 		JBrowse link
G Lair1 leukocyte-associated immunoglobulin-like receptor 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of LAIR1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LAIR1 mRNA] 		CTD PMID:28003376 NCBI chr 1:79,140,850...79,261,546
Ensembl chr 1:79,198,311...79,258,037 		JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LAMP3 mRNA] CTD PMID:28003376 NCBI chr11:94,657,817...94,726,451
Ensembl chr11:94,661,399...94,726,195 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of LCK mRNA] CTD PMID:28003376 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267 		JBrowse link
G Ldlrad3 low density lipoprotein receptor class A domain containing 3 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of LDLRAD3 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LDLRAD3 mRNA] 		CTD PMID:28003376 NCBI chr 3:108,694,528...108,936,330
Ensembl chr 3:108,694,528...108,936,368 		JBrowse link
G Lgmn legumain multiple interactions ISO LGMN gene mutant form inhibits the reaction [gardiquimod results in increased secretion of IL6 protein] CTD PMID:22916010 NCBI chr 6:127,308,913...127,347,355
Ensembl chr 6:127,308,913...127,347,328 		JBrowse link
G Lilra5 leukocyte immunoglobulin like receptor A5 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LILRA5 mRNA] CTD PMID:28003376 NCBI chr 1:79,011,865...79,073,860
Ensembl chr 1:79,045,546...79,050,111 		JBrowse link
G LOC100912356 interferon alpha-1-like increases expression
multiple interactions 		ISO gardiquimod results in increased expression of IFNA5 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IFNA5 mRNA] 		CTD PMID:28003376 NCBI chr 5:108,343,570...108,346,248 JBrowse link
G Lpxn leupaxin decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of LPXN mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of LPXN mRNA] 		CTD PMID:28003376 NCBI chr 1:219,353,319...219,387,743
Ensembl chr 1:219,353,708...219,387,742 		JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of LRG1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LRG1 mRNA] 		CTD PMID:28003376 NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:1,034,679...1,037,337 		JBrowse link
G Manba mannosidase beta decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of MANBA mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of MANBA mRNA] 		CTD PMID:28003376 NCBI chr 2:226,583,968...226,676,520
Ensembl chr 2:226,583,917...226,676,517 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of MAP3K5 mRNA] CTD PMID:28003376 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of MAP3K8 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of MAP3K8 mRNA] 		CTD PMID:28003376 NCBI chr17:58,078,175...58,098,455
Ensembl chr17:58,078,320...58,098,452 		JBrowse link
G Marco macrophage receptor with collagenous structure increases expression
multiple interactions 		ISO gardiquimod results in increased expression of MARCO mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of MARCO mRNA] 		CTD PMID:28003376 NCBI chr13:34,169,011...34,210,340
Ensembl chr13:34,169,011...34,201,255 		JBrowse link
G Mcoln2 mucolipin TRP cation channel 2 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of MCOLN2 mRNA] CTD PMID:28003376 NCBI chr 2:237,714,100...237,762,979
Ensembl chr 2:237,714,084...237,762,978 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of MGST1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of MGST1 mRNA] 		CTD PMID:28003376 NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875 		JBrowse link
G Mpzl3 myelin protein zero-like 3 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of MPZL3 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of MPZL3 mRNA] 		CTD PMID:28003376 NCBI chr 8:54,257,235...54,277,422
Ensembl chr 8:54,257,226...54,279,665 		JBrowse link
G Mreg melanoregulin increases expression
multiple interactions 		ISO gardiquimod results in increased expression of MREG mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of MREG mRNA] 		CTD PMID:28003376 NCBI chr 9:81,236,019...81,291,601
Ensembl chr 9:81,236,019...81,291,310 		JBrowse link
G Ms4a6a membrane spanning 4-domains A6A decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of MS4A6A mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of MS4A6A mRNA] 		CTD PMID:28003376 NCBI chr 1:217,826,261...217,839,606
Ensembl chr 1:217,826,261...217,850,013 		JBrowse link
G Nabp1 nucleic acid binding protein 1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of NABP1 mRNA] CTD PMID:28003376 NCBI chr 9:57,570,326...57,625,926
Ensembl chr 9:57,618,505...57,626,052 		JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of NDUFA12 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of NDUFA12 mRNA] 		CTD PMID:28003376 NCBI chr 7:30,658,316...30,685,302
Ensembl chr 7:30,658,322...30,686,300 		JBrowse link
G Nek6 NIMA-related kinase 6 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of NEK6 mRNA] CTD PMID:28003376 NCBI chr 3:42,693,994...42,766,026
Ensembl chr 3:42,693,971...42,767,773 		JBrowse link
G Nemp1 nuclear envelope integral membrane protein 1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of NEMP1 mRNA] CTD PMID:28003376 NCBI chr 7:65,399,297...65,424,054
Ensembl chr 7:65,399,381...65,424,055 		JBrowse link
G Nexn nexilin (F actin binding protein) increases expression
multiple interactions 		ISO gardiquimod results in increased expression of NEXN mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of NEXN mRNA] 		CTD PMID:28003376 NCBI chr 2:243,846,736...243,878,268
Ensembl chr 2:243,846,433...243,887,114 		JBrowse link
G Nup214 nucleoporin 214 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of NUP214 mRNA] CTD PMID:28003376 NCBI chr 3:35,652,841...35,738,323
Ensembl chr 3:35,652,858...35,739,192 		JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of P2RX7 mRNA] CTD PMID:28003376 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193 		JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of PAQR8 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PAQR8 mRNA] 		CTD PMID:28003376 NCBI chr 9:30,808,921...30,858,599
Ensembl chr 9:30,808,923...30,861,043 		JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of PDCD1LG2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PDCD1LG2 mRNA] 		CTD PMID:28003376 NCBI chr 1:236,572,497...236,637,490
Ensembl chr 1:236,565,526...236,637,490 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of PID1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of PID1 mRNA] 		CTD PMID:28003376 NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PIM1 mRNA] CTD PMID:28003376 NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764 		JBrowse link
G Plagl2 PLAG1 like zinc finger 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of PLAGL2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PLAGL2 mRNA] 		CTD PMID:28003376 NCBI chr 3:162,155,554...162,168,748
Ensembl chr 3:162,155,554...162,168,748 		JBrowse link
G Plekhg1 pleckstrin homology and RhoGEF domain containing G1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PLEKHG1 mRNA] CTD PMID:28003376 NCBI chr 1:42,612,023...42,841,727
Ensembl chr 1:42,612,122...42,841,719 		JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PLOD2 mRNA] CTD PMID:28003376 NCBI chr 8:101,964,318...102,047,022
Ensembl chr 8:101,964,318...102,047,022 		JBrowse link
G Ppp1r17 protein phosphatase 1, regulatory subunit 17 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PPP1R17 mRNA] CTD PMID:28003376 NCBI chr 4:86,544,024...86,560,839
Ensembl chr 4:86,544,121...86,560,835 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of PTGS2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PTGS2 mRNA] 		CTD PMID:28003376 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptx3 pentraxin 3 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of PTX3 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PTX3 mRNA] 		CTD PMID:28003376 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372 		JBrowse link
G Rab33a RAB33A, member RAS oncogene family multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of RAB33A mRNA] CTD PMID:28003376 NCBI chr  X:132,572,133...132,584,255
Ensembl chr  X:132,572,148...132,584,254 		JBrowse link
G Rassf4 Ras association domain family member 4 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of RASSF4 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of RASSF4 mRNA] 		CTD PMID:28003376 NCBI chr 4:151,569,984...151,605,203
Ensembl chr 4:151,569,984...151,604,883 		JBrowse link
G Rbp7 retinol binding protein 7 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of RBP7 mRNA] CTD PMID:28003376 NCBI chr 5:165,169,700...165,177,427
Ensembl chr 5:165,172,785...165,177,399 		JBrowse link
G Rcbtb2 RCC1 and BTB domain containing protein 2 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of RCBTB2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of RCBTB2 mRNA] 		CTD PMID:28003376 NCBI chr15:54,729,367...54,774,004
Ensembl chr15:54,729,332...54,793,313 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of RGS16 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of RGS16 mRNA] 		CTD PMID:28003376 NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313 		JBrowse link
G Rnd1 Rho family GTPase 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of RND1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of RND1 mRNA] 		CTD PMID:28003376 NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392 		JBrowse link
G Rnf130 ring finger protein 130 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of RNF130 mRNA] CTD PMID:28003376 NCBI chr10:34,843,920...34,957,130
Ensembl chr10:34,843,915...34,960,408 		JBrowse link
G Rnf144b ring finger protein 144B increases expression
multiple interactions 		ISO gardiquimod results in increased expression of RNF144B mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of RNF144B mRNA] 		CTD PMID:28003376 NCBI chr17:17,637,564...17,786,685
Ensembl chr17:17,639,079...17,769,037 		JBrowse link
G RT1-DMb RT1 class II, locus DMb decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of HLA-DMB mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of HLA-DMB mRNA] 		CTD PMID:28003376 NCBI chr20:4,695,009...4,702,560
Ensembl chr20:4,695,010...4,702,246 		JBrowse link
G Sdc2 syndecan 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of SDC2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SDC2 mRNA] 		CTD PMID:28003376 NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:66,108,853...66,126,294 		JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of SLAMF1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SLAMF1 mRNA] 		CTD PMID:28003376 NCBI chr13:86,802,708...86,837,890
Ensembl chr13:86,802,708...86,837,890 		JBrowse link
G Slamf7 SLAM family member 7 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SLAMF7 mRNA] CTD PMID:28003376 NCBI chr13:86,668,060...86,688,222
Ensembl chr13:86,668,060...86,686,341 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of SLC30A1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SLC30A1 mRNA] 		CTD PMID:28003376 NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892 		JBrowse link
G Slc4a10 solute carrier family 4 member 10 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of SLC4A10 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SLC4A10 mRNA] 		CTD PMID:28003376 NCBI chr 3:67,050,925...67,367,637
Ensembl chr 3:66,770,954...67,367,646 		JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SLCO4A1 mRNA] CTD PMID:28003376 NCBI chr 3:187,936,735...187,955,873
Ensembl chr 3:187,936,820...187,955,871 		JBrowse link
G Smco4 single-pass membrane protein with coiled-coil domains 4 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of SMCO4 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SMCO4 mRNA] 		CTD PMID:28003376 NCBI chr 8:20,594,633...20,646,916
Ensembl chr 8:20,627,338...20,646,916 		JBrowse link
G Smim3 small integral membrane protein 3 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of SMIM3 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SMIM3 mRNA] 		CTD PMID:28003376 NCBI chr18:56,200,458...56,252,778
Ensembl chr18:56,200,459...56,227,379 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A increases expression
multiple interactions 		ISO gardiquimod results in increased expression of SMPDL3A mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SMPDL3A mRNA] 		CTD PMID:28003376 NCBI chr20:37,679,004...37,701,979
Ensembl chr20:37,678,964...37,704,260 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of SOCS1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SOCS1 mRNA] 		CTD PMID:28003376 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of SOCS2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SOCS2 mRNA] 		CTD PMID:28003376 NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:31,874,463...31,930,423 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SOCS3 mRNA] CTD PMID:28003376 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Sort1 sortilin 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of SORT1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SORT1 mRNA] 		CTD PMID:28003376 NCBI chr 2:198,609,466...198,690,481
Ensembl chr 2:198,612,148...198,690,481 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SOS1 mRNA] CTD PMID:28003376 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SPP1 mRNA] CTD PMID:28003376 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Sucnr1 succinate receptor 1 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SUCNR1 mRNA] CTD PMID:28003376 NCBI chr 2:146,368,858...146,380,360
Ensembl chr 2:146,368,858...146,380,360 		JBrowse link
G Taf4b TATA-box binding protein associated factor 4b multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TAF4B mRNA] CTD PMID:28003376 NCBI chr18:6,227,299...6,360,970
Ensembl chr18:6,227,345...6,356,275 		JBrowse link
G Tapbp TAP binding protein multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TAPBP mRNA] CTD PMID:28003376 NCBI chr20:4,958,821...4,967,958
Ensembl chr20:4,959,926...4,971,834 		JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of TBXAS1 mRNA] CTD PMID:28003376 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of TCF7L2 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TCF7L2 mRNA] 		CTD PMID:28003376 NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225 		JBrowse link
G Tfrc transferrin receptor increases expression
multiple interactions 		ISO gardiquimod results in increased expression of TFRC mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TFRC mRNA] 		CTD PMID:28003376 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Thbs1 thrombospondin 1 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of THBS1 mRNA] CTD PMID:28003376 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402 		JBrowse link
G Tifa TRAF-interacting protein with forkhead-associated domain increases expression
multiple interactions 		ISO gardiquimod results in increased expression of TIFA mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TIFA mRNA] 		CTD PMID:28003376 NCBI chr 2:218,927,724...218,942,111
Ensembl chr 2:218,909,915...218,956,224 		JBrowse link
G Tifab TIFA inhibitor multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TIFAB mRNA] CTD PMID:28003376 NCBI chr17:8,438,622...8,441,750
Ensembl chr17:8,433,862...8,444,360 		JBrowse link
G Tlr7 toll-like receptor 7 increases activity
increases expression
multiple interactions 		ISO gardiquimod results in increased activity of TLR7 protein
gardiquimod results in increased expression of TLR7 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TLR7 mRNA] 		CTD PMID:26682054 PMID:28003376 NCBI chr  X:30,644,324...30,670,796
Ensembl chr  X:30,644,355...30,672,151 		JBrowse link
G Tlr8 toll-like receptor 8 multiple interactions
increases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TLR8 mRNA] CTD PMID:28003376 NCBI chr  X:30,708,714...30,733,104
Ensembl chr  X:30,708,033...30,737,079 		JBrowse link
G Tmem14c transmembrane protein 14C decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of TMEM14C mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of TMEM14C mRNA] 		CTD PMID:28003376 NCBI chr17:23,939,501...23,945,622
Ensembl chr17:23,939,509...23,959,055 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions 		ISO gardiquimod results in increased expression of TNF mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TNF mRNA] 		CTD PMID:28003376 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnip3 TNFAIP3 interacting protein 3 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of TNIP3 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TNIP3 mRNA] 		CTD PMID:28003376 NCBI chr 4:96,197,019...96,237,357
Ensembl chr 4:96,140,768...96,238,534 		JBrowse link
G Tpra1 transmembrane protein adipocyte associated 1 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of TPRA1 mRNA] CTD PMID:28003376 NCBI chr 4:122,921,304...122,932,519
Ensembl chr 4:122,921,323...122,932,517 		JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of VAV1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of VAV1 mRNA] 		CTD PMID:28003376 NCBI chr 9:2,248,856...2,295,905
Ensembl chr 9:2,248,914...2,296,922 		JBrowse link
G Vrk2 VRK serine/threonine kinase 2 multiple interactions
decreases expression 		ISO Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of VRK2 mRNA] CTD PMID:28003376 NCBI chr14:104,514,815...104,635,549
Ensembl chr14:104,514,100...104,720,933 		JBrowse link
G Wdfy1 WD repeat and FYVE domain containing 1 increases expression
multiple interactions 		ISO gardiquimod results in increased expression of WDFY1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of WDFY1 mRNA] 		CTD PMID:28003376 NCBI chr 9:88,459,613...88,541,215
Ensembl chr 9:88,489,227...88,541,186 		JBrowse link
G Ypel4 yippee-like 4 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of YPEL4 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of YPEL4 mRNA] 		CTD PMID:28003376 NCBI chr 3:90,222,060...90,227,395
Ensembl chr 3:90,222,803...90,227,381 		JBrowse link
G Zfp467 zinc finger protein 467 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of ZNF467 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of ZNF467 mRNA] 		CTD PMID:28003376 NCBI chr 4:78,716,473...78,725,829
Ensembl chr 4:78,716,666...78,723,135 		JBrowse link
G Znrf1 zinc and ring finger 1 decreases expression
multiple interactions 		ISO gardiquimod results in decreased expression of ZNRF1 mRNA
Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of ZNRF1 mRNA] 		CTD PMID:28003376 NCBI chr19:56,403,816...56,490,901
Ensembl chr19:56,405,728...56,490,881 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        immunomodulator 15087
          gardiquimod 171
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteropolycyclic compound 18616
                                    organic heterotricyclic compound 16085
                                      imidazoquinoline 347
                                        gardiquimod 171
paths to the root