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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ranirestat
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Accession:CHEBI:233577 term browser browse the term
Synonyms:exact_synonym: (3R)-2'-[(4-bromo-2-fluorophenyl)methyl]spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5-tetrone
 related_synonym: AS-3201;   Formula=C17H11BrFN3O4;   InChI=1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1;   InChIKey=QCVNMNYRNIMDKV-QGZVFWFLSA-N;   SMILES=O=C1N=C(O)CC12C(=O)N(C(=O)C3=CC=CN32)CC4=CC=C(Br)C=C4F;   SX-3030
 xref: CAS:147254-64-6;   DrugBank:DB05327;   KEGG:D06403
 xref_mesh: MESH:C115070
 xref: PMID:32367058;   Wikipedia:https://en.wikipedia.org/wiki/Ranirestat


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ranirestat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO ranirestat inhibits the reaction [[AKR1C3 protein results in increased metabolism of Idarubicin] which results in increased abundance of idarubicinol] CTD PMID:38175295 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438 		JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO ranirestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol] CTD PMID:32367058 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:129,638,302...129,686,100 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glycosylation
increases glucuronidation 		ISO UGT1A1 protein results in increased glycosylation of ranirestat
UGT1A1 protein results in increased glucuronidation of ranirestat 		CTD PMID:15013842 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glycosylation
increases glucuronidation 		ISO UGT1A3 protein results in increased glycosylation of ranirestat
UGT1A3 protein results in increased glucuronidation of ranirestat 		CTD PMID:15013842 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glycosylation
increases glucuronidation 		ISO UGT1A4 protein results in increased glycosylation of ranirestat
UGT1A4 protein results in increased glucuronidation of ranirestat 		CTD PMID:15013842 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of ranirestat CTD PMID:15013842 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glycosylation ISO UGT2B7 protein results in increased glycosylation of ranirestat CTD PMID:15013842 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:21,251,535...21,274,451 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          carbon atom 20710
            organic molecular entity 20710
              ranirestat 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon group molecular entity 20715
                          organic molecular entity 20710
                            ranirestat 7
paths to the root