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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:CU-CPT22
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Accession:CHEBI:233358 term browser browse the term
Definition:CU-CPT22 is a potent protein complex of toll-like receptor 1 and 2 (TLR1/2) inhibitor, and competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with a Ki of 0.41 uM. CU-CPT22 blocks Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 uM.
Synonyms:related_synonym: 1416324-85-0;   Formula=C19H22O7;   InChI=1S/C19H22O7/c1-3-4-5-6-7-26-19(24)12-8-11-10-14(25-2)17(22)18(23)15(11)16(21)13(20)9-12/h8-10,22-23H,3-7H2,1-2H3,(H,20,21);   InChIKey=UBQFTTUFRSSOHE-UHFFFAOYSA-N;   SMILES=O=C(OCCCCCC)C=1C=C(O)C(=O)C=2C(O)=C(O)C(OC)=CC2C1;   hexyl 3,4,6-trihydroxy-2-methoxy-5-oxo-5H-benzo[7]annulene-8-carboxylate
 xref: CAS:1416324-85-0
 xref_mesh: MESH:C000719992


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CU-CPT22 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 multiple interactions ISO CU-CPT22 inhibits the reaction [Particulate Matter results in decreased expression of CDH1 protein] CTD PMID:39189708 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO CU-CPT22 inhibits the reaction [tributyltin results in increased expression of IL1B protein] CTD PMID:35405286 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO CU-CPT22 inhibits the reaction [tributyltin results in increased expression of IL6 protein] CTD PMID:35405286 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO CU-CPT22 inhibits the reaction [Particulate Matter results in increased expression of MYD88 mRNA]; CU-CPT22 inhibits the reaction [Particulate Matter results in increased expression of MYD88 protein] CTD PMID:39189708 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Ocln occludin multiple interactions ISO CU-CPT22 inhibits the reaction [Particulate Matter results in decreased expression of OCLN protein] CTD PMID:39189708 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO CU-CPT22 inhibits the reaction [Particulate Matter results in increased expression of RELA mRNA]; CU-CPT22 inhibits the reaction [Particulate Matter results in increased phosphorylation of RELA protein] CTD PMID:39189708 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO CU-CPT22 inhibits the reaction [Particulate Matter results in decreased expression of TJP1 protein] CTD PMID:39189708 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
G Tlr2 toll-like receptor 2 decreases expression
multiple interactions 		ISO CU-CPT22 results in decreased expression of TLR2 mRNA; CU-CPT22 results in decreased expression of TLR2 protein
CU-CPT22 inhibits the reaction [Particulate Matter results in increased expression of TLR2 mRNA]; CU-CPT22 inhibits the reaction [Particulate Matter results in increased expression of TLR2 protein] 		CTD PMID:39189708 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO CU-CPT22 inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; CU-CPT22 inhibits the reaction [Particulate Matter results in increased expression of TNF protein] CTD PMID:39189708 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO CU-CPT22 inhibits the reaction [Particulate Matter results in increased expression of TRAF6 mRNA]; CU-CPT22 inhibits the reaction [Particulate Matter results in increased expression of TRAF6 protein] CTD PMID:39189708 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          carbon atom 20710
            organic molecular entity 20710
              CU-CPT22 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            CU-CPT22 10
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