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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(-)-acanthoic acid
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Accession:CHEBI:233299 term browser browse the term
Synonyms:related_synonym: Formula=C20H30O2;   InChI=1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,9,14,16H,1,6-8,10-13H2,2-4H3,(H,21,22)/t14-,16-,18-,19-,20+/m0/s1;   InChIKey=TVHDZSRRHQKNEZ-MGFONVBGSA-N;   SMILES=[H]C12C(=CCC(C=C)(C)C1)C3(C)CCCC(C(=O)O)(C)C3([H])CC2
 xref: CAS:119290-87-8
 xref_mesh: MESH:C099958
 xref: PMID:39057081


show annotations for term's descendants           Sort by:
(-)-acanthoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase multiple interactions ISO acanthoic acid inhibits the reaction [Dietary Fats results in increased expression of ACLY mRNA]; acanthoic acid inhibits the reaction [Palmitic Acid results in increased expression of ACLY mRNA] CTD PMID:31421115 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO 		acanthoic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
acanthoic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; acanthoic acid inhibits the reaction [Dietary Fats results in increased expression of ACTA2 mRNA]; acanthoic acid inhibits the reaction [Dietary Fats results in increased expression of ACTA2 protein]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of ACTA2 mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] 		CTD PMID:24802811 PMID:28964808 PMID:31421115 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO acanthoic acid inhibits the reaction [Ethanol results in increased expression of ADGRE1 protein] CTD PMID:28964808 NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of CASP1 mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of CASP1 mRNA]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of CASP1 mRNA]] CTD PMID:28964808 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO acanthoic acid inhibits the reaction [Dietary Fats results in increased expression of COL1A1 mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of COL1A1 mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of COL1A1 protein] CTD PMID:28964808 PMID:31421115 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO acanthoic acid inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of FASN mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of FASN protein]; acanthoic acid inhibits the reaction [Palmitic Acid results in increased expression of FASN mRNA] CTD PMID:28964808 PMID:31421115 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]
acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA]; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]] 		CTD PMID:28964808 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in decreased expression of IL1A mRNA] CTD PMID:28964808 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein]; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]] CTD PMID:28964808 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA]
acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL6 mRNA] 		CTD PMID:28964808 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO acanthoic acid inhibits the reaction [Ethanol results in increased expression of IRAK1 protein] CTD PMID:28964808 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:156,920,081...156,929,825 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 multiple interactions ISO acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IRAK4 mRNA]; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IRAK4 protein]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of IRAK4 protein]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IRAK4 protein]] CTD PMID:28964808 NCBI chr 7:127,561,777...127,588,762
Ensembl chr 7:127,561,717...127,597,109 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO acanthoic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP13 protein] CTD PMID:24802811 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO acanthoic acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein] CTD PMID:24802811 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein] CTD PMID:28964808 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions EXP
ISO 		acanthoic acid inhibits the reaction [TGFB1 protein results in increased expression of NR1H2 protein]
acanthoic acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of NR1H2 protein]; acanthoic acid inhibits the reaction [Dietary Fats results in decreased expression of NR1H2 mRNA]; acanthoic acid inhibits the reaction [Dietary Fats results in decreased expression of NR1H2 protein]; acanthoic acid inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 mRNA]; acanthoic acid inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 protein] 		CTD PMID:24802811 PMID:31421115 NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:104,178,234...104,183,863 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression
multiple interactions 		ISO acanthoic acid results in increased expression of NR1H3 protein
acanthoic acid inhibits the reaction [Dietary Fats results in decreased expression of NR1H3 mRNA]; acanthoic acid inhibits the reaction [Dietary Fats results in decreased expression of NR1H3 protein]; acanthoic acid inhibits the reaction [Palmitic Acid results in decreased expression of NR1H3 mRNA]; acanthoic acid inhibits the reaction [Palmitic Acid results in decreased expression of NR1H3 protein] 		CTD PMID:24802811 PMID:31421115 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO acanthoic acid inhibits the reaction [Dietary Fats results in decreased expression of NR1H4 mRNA]; acanthoic acid inhibits the reaction [Dietary Fats results in decreased expression of NR1H4 protein]; acanthoic acid inhibits the reaction [Palmitic Acid results in decreased expression of NR1H4 mRNA]; acanthoic acid inhibits the reaction [Palmitic Acid results in decreased expression of NR1H4 protein] CTD PMID:31421115 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO acanthoic acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]; acanthoic acid inhibits the reaction [Ethanol results in decreased expression of PPARA protein] CTD PMID:28964808 PMID:31421115 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO acanthoic acid inhibits the reaction [Dietary Fats results in increased expression of PPARG protein]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of PPARG protein] CTD PMID:28964808 PMID:31421115 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of CASP1 mRNA]]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IRAK4 protein]]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of TNF mRNA]] CTD PMID:28964808 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO acanthoic acid inhibits the reaction [Dietary Fats results in increased expression of SCD1 mRNA]; acanthoic acid inhibits the reaction [Palmitic Acid results in increased expression of SCD1 mRNA] CTD PMID:31421115 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO acanthoic acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 protein]; acanthoic acid inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] CTD PMID:28964808 PMID:31421115 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO acanthoic acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]; acanthoic acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 protein]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; acanthoic acid inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]; acanthoic acid inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein] CTD PMID:28964808 PMID:31421115 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO acanthoic acid inhibits the reaction [Dietary Fats results in increased phosphorylation of STK11 protein]; acanthoic acid inhibits the reaction [Ethanol results in decreased phosphorylation of STK11 protein] CTD PMID:28964808 PMID:31421115 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:10,225,204...10,241,965 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP acanthoic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; acanthoic acid inhibits the reaction [TGFB1 protein results in increased expression of NR1H2 protein] CTD PMID:24802811 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO acanthoic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]; acanthoic acid inhibits the reaction [Dietary Fats results in increased expression of TIMP1 mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of TIMP1 mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of TIMP1 protein] CTD PMID:24802811 PMID:28964808 PMID:31421115 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO acanthoic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of TNF mRNA]] 		CTD PMID:24802811 PMID:28964808 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
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  CHEBI ontology 20862
    role 20820
      application 20621
        anti-inflammatory agent 16834
          (-)-acanthoic acid 28
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    subatomic particle 20860
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                  main group element atom 20781
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                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            (-)-acanthoic acid 28
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