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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Perhexiline maleate
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Accession:CHEBI:232991 term browser browse the term
Definition:PERHEXILINE MALEATE is a small molecule drug with a maximum clinical trial phase of IV that was first approved in 1974. It was withdrawn in at least one region.
Synonyms:related_synonym: (Z)-but-2-enedioic acid;2-(2,2-dicyclohexylethyl)piperidine;   Formula=C19H35N.C4H4O4;   InChI=1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-;   InChIKey=JDZOTSLZMQDFLG-BTJKTKAUSA-N;   Pexid;   SMILES=C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3.C(\\[H])(=C(\\[H])/C(=O)O)/C(=O)O
 xref: CAS:6724-53-4
 xref_mesh: MESH:C023470



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Perhexiline maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 increases expression
multiple interactions
ISO perhexiline maleate results in increased expression of ATF4 mRNA; perhexiline maleate results in increased expression of ATF4 protein
4-phenylbutyric acid inhibits the reaction [perhexiline maleate results in increased expression of ATF4 protein]; [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF4 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF4 mRNA]; SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of ATF4 protein]
CTD PMID:33309543 PMID:36083301 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases expression
ISO [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF6 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF6 mRNA]
perhexiline maleate results in increased expression of ATF6 mRNA
CTD PMID:33309543 PMID:36083301 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline]; CYP1A2 protein results in increased metabolism of [perhexiline maleate results in increased abundance of Perhexiline] CTD PMID:36083301 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO CYP2C19 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline]; CYP2C19 protein results in increased metabolism of [perhexiline maleate results in increased abundance of Perhexiline] CTD PMID:36083301 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF4 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF6 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 protein]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of EIF2AK3 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ERN1 mRNA]; CYP2D6 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline] CTD PMID:36083301 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline]; CYP3A4 protein results in increased metabolism of [perhexiline maleate results in increased abundance of Perhexiline] CTD PMID:36083301 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO perhexiline maleate results in increased expression of DDIT3 mRNA; perhexiline maleate results in increased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [perhexiline maleate results in increased expression of DDIT3 protein]; [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 mRNA; [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 protein; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 protein]; SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of DDIT3 protein]
CTD PMID:33309543 PMID:36083301 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases expression
ISO [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of EIF2AK3 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of EIF2AK3 mRNA]
perhexiline maleate results in increased expression of EIF2AK3 mRNA
CTD PMID:33309543 PMID:36083301 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO perhexiline maleate results in increased phosphorylation of EIF2S1 protein CTD PMID:33309543 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression
ISO [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ERN1 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ERN1 mRNA]
perhexiline maleate results in increased expression of ERN1 mRNA
CTD PMID:33309543 PMID:36083301 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO perhexiline maleate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO perhexiline maleate results in increased splicing of XBP1 mRNA CTD PMID:33309543 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19879
    chemical entity 19877
      atom 19877
        nonmetal atom 19800
          carbon atom 19753
            organic molecular entity 19753
              Perhexiline maleate 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19879
    subatomic particle 19877
      composite particle 19877
        hadron 19877
          baryon 19877
            nucleon 19877
              atomic nucleus 19877
                atom 19877
                  main group element atom 19816
                    p-block element atom 19816
                      carbon group element atom 19756
                        carbon atom 19753
                          organic molecular entity 19753
                            Perhexiline maleate 12
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