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G |
Atf4 |
activating transcription factor 4 |
increases expression multiple interactions |
ISO |
perhexiline maleate results in increased expression of ATF4 mRNA; perhexiline maleate results in increased expression of ATF4 protein 4-phenylbutyric acid inhibits the reaction [perhexiline maleate results in increased expression of ATF4 protein]; [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF4 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF4 mRNA]; SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of ATF4 protein] |
CTD |
PMID:33309543 PMID:36083301 |
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NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions increases expression |
ISO |
[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF6 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF6 mRNA] perhexiline maleate results in increased expression of ATF6 mRNA |
CTD |
PMID:33309543 PMID:36083301 |
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NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
CYP1A2 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline]; CYP1A2 protein results in increased metabolism of [perhexiline maleate results in increased abundance of Perhexiline] |
CTD |
PMID:36083301 |
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NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions |
ISO |
CYP2C19 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline]; CYP2C19 protein results in increased metabolism of [perhexiline maleate results in increased abundance of Perhexiline] |
CTD |
PMID:36083301 |
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NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF4 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF6 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 protein]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of EIF2AK3 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ERN1 mRNA]; CYP2D6 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline] |
CTD |
PMID:36083301 |
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NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
CYP3A4 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline]; CYP3A4 protein results in increased metabolism of [perhexiline maleate results in increased abundance of Perhexiline] |
CTD |
PMID:36083301 |
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NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO |
perhexiline maleate results in increased expression of DDIT3 mRNA; perhexiline maleate results in increased expression of DDIT3 protein 4-phenylbutyric acid inhibits the reaction [perhexiline maleate results in increased expression of DDIT3 protein]; [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 mRNA; [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 protein; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 protein]; SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of DDIT3 protein] |
CTD |
PMID:33309543 PMID:36083301 |
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NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases expression |
ISO |
[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of EIF2AK3 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of EIF2AK3 mRNA] perhexiline maleate results in increased expression of EIF2AK3 mRNA |
CTD |
PMID:33309543 PMID:36083301 |
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NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation |
ISO |
perhexiline maleate results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:33309543 |
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NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions increases expression |
ISO |
[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ERN1 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ERN1 mRNA] perhexiline maleate results in increased expression of ERN1 mRNA |
CTD |
PMID:33309543 PMID:36083301 |
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NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
perhexiline maleate results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
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G |
Xbp1 |
X-box binding protein 1 |
increases splicing |
ISO |
perhexiline maleate results in increased splicing of XBP1 mRNA |
CTD |
PMID:33309543 |
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NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693
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