CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: ABT-100
Accession: CHEBI:232865
browse the term
Synonyms: exact_synonym: 4-[(2S)-2-(4-cyanophenyl)-2-hydroxy-2-(3-methylimidazol-4-yl)ethoxy]-3-[4-(trifluoromethoxy)phenyl]benzonitrile
related_synonym: Formula=C27H19F3N4O3; InChI=1S/C27H19F3N4O3/c1-34-17-33-15-25(34)26(35,21-7-2-18(13-31)3-8-21)16-36-24-11-4-19(14-32)12-23(24)20-5-9-22(10-6-20)37-27(28,29)30/h2-12,15,17,35H,16H2,1H3/t26-/m0/s1; InChIKey=HEUVRFNVTLGKMZ-SANMLTNESA-N; SMILES=CN1C=NC=C1[C@](COC=2C=CC(=CC2C3=CC=C(C=C3)OC(F)(F)F)C#N)(C4=CC=C(C=C4)C#N)O
xref: CAS:450839-40-4
xref_mesh: MESH:C503142
xref: PMID:37987370
G
Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
ABT-100 results in decreased phosphorylation of AKT1 protein
CTD
PMID:15930366
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Cdk2
cyclin dependent kinase 2
decreases activity
ISO
ABT-100 results in decreased activity of CDK2 protein
CTD
PMID:15930366
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
decreases phosphorylation increases expression
ISO
ABT-100 results in decreased phosphorylation of CDKN1B protein ABT-100 results in increased expression of CDKN1B protein
CTD
PMID:15930366
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
G
Hras
HRas proto-oncogene, GTPase
decreases farnesylation
ISO
ABT-100 results in decreased farnesylation of HRAS protein
CTD
PMID:15930366
NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
decreases phosphorylation
ISO
ABT-100 results in decreased phosphorylation of PIK3R1 protein
CTD
PMID:15930366
NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all