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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ABT-100
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Accession:CHEBI:232865 term browser browse the term
Synonyms:exact_synonym: 4-[(2S)-2-(4-cyanophenyl)-2-hydroxy-2-(3-methylimidazol-4-yl)ethoxy]-3-[4-(trifluoromethoxy)phenyl]benzonitrile
 related_synonym: Formula=C27H19F3N4O3;   InChI=1S/C27H19F3N4O3/c1-34-17-33-15-25(34)26(35,21-7-2-18(13-31)3-8-21)16-36-24-11-4-19(14-32)12-23(24)20-5-9-22(10-6-20)37-27(28,29)30/h2-12,15,17,35H,16H2,1H3/t26-/m0/s1;   InChIKey=HEUVRFNVTLGKMZ-SANMLTNESA-N;   SMILES=CN1C=NC=C1[C@](COC=2C=CC(=CC2C3=CC=C(C=C3)OC(F)(F)F)C#N)(C4=CC=C(C=C4)C#N)O
 xref: CAS:450839-40-4
 xref_mesh: MESH:C503142
 xref: PMID:37987370



show annotations for term's descendants           Sort by:
ABT-100 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO ABT-100 results in decreased phosphorylation of AKT1 protein CTD PMID:15930366 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO ABT-100 results in decreased activity of CDK2 protein CTD PMID:15930366 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases phosphorylation
increases expression
ISO ABT-100 results in decreased phosphorylation of CDKN1B protein
ABT-100 results in increased expression of CDKN1B protein
CTD PMID:15930366 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases farnesylation ISO ABT-100 results in decreased farnesylation of HRAS protein CTD PMID:15930366 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases phosphorylation ISO ABT-100 results in decreased phosphorylation of PIK3R1 protein CTD PMID:15930366 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19879
    chemical entity 19877
      atom 19877
        nonmetal atom 19800
          carbon atom 19753
            organic molecular entity 19753
              ABT-100 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19879
    subatomic particle 19877
      composite particle 19877
        hadron 19877
          baryon 19877
            nucleon 19877
              atomic nucleus 19877
                atom 19877
                  main group element atom 19816
                    p-block element atom 19816
                      carbon group element atom 19756
                        carbon atom 19753
                          organic molecular entity 19753
                            ABT-100 5
paths to the root