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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:NMS-873
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Accession:CHEBI:232809 term browser browse the term
Synonyms:exact_synonym: 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine
 related_synonym: Formula=C27H28N4O3S2;   InChI=1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2,32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6,9-17,23H,3-4,7-8,18H2,1-2H3;   InChIKey=UJGTUKMAJVCBIS-UHFFFAOYSA-N;   SMILES=CC1=CC(=CC=C1C2=CC=C(C=C2)S(C)(=O)=O)OCC3=NN=C(N3C=4C=CC=NC4)SC5CCCC5
 xref: CAS:1418013-75-8
 xref_mesh: MESH:C000623013
 xref: PMID:28322724



show annotations for term's descendants           Sort by:
NMS-873 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor multiple interactions ISO NMS-873 promotes the reaction [AMFR protein binds to VCP protein] CTD PMID:27105284 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO NMS-873 results in increased expression of BAX protein CTD PMID:29693262 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO NMS-873 results in decreased expression of BCL2 protein CTD PMID:29693262 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Canx calnexin increases expression ISO NMS-873 results in increased expression of CANX protein CTD PMID:29693262 NCBI chr10:35,124,941...35,157,954
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
ISO NMS-873 results in increased cleavage of CASP3 protein
NMS-873 results in increased activity of CASP3 protein
CTD PMID:23892893 PMID:27434122 PMID:29693262 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO NMS-873 results in increased activity of CASP7 protein CTD PMID:27434122 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 increases activity ISO NMS-873 results in increased activity of CASP9 protein CTD PMID:29693262 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccne1 cyclin E1 increases stability ISO NMS-873 results in increased stability of CCNE1 protein CTD PMID:23892893 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO NMS-873 results in decreased expression of CDH1 protein CTD PMID:29693262 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO NMS-873 results in decreased expression of CDH2 protein CTD PMID:29693262 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO NMS-873 results in increased expression of CDKN1A protein CTD PMID:29693262 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO NMS-873 results in increased expression of CDKN1B protein CTD PMID:29693262 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO NMS-873 results in increased expression of DDIT3 protein CTD PMID:23892893 PMID:29693262 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO NMS-873 results in increased expression of EIF2AK3 protein CTD PMID:29693262 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO NMS-873 results in increased expression of ERN1 protein CTD PMID:29693262 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO NMS-873 results in increased expression of ERO1A protein CTD PMID:29693262 NCBI chr15:20,974,771...21,010,170
Ensembl chr15:18,492,945...18,530,478
JBrowse link
G Faf1 Fas associated factor 1 multiple interactions ISO NMS-873 promotes the reaction [FAF1 protein binds to VCP protein] CTD PMID:27105284 NCBI chr 5:129,654,677...130,018,604
Ensembl chr 5:124,426,062...124,789,977
JBrowse link
G Faf2 Fas associated factor family member 2 multiple interactions ISO NMS-873 promotes the reaction [FAF2 protein binds to VCP protein] CTD PMID:27105284 NCBI chr17:9,952,329...9,994,596
Ensembl chr17:9,947,220...9,989,485
JBrowse link
G Fasn fatty acid synthase decreases expression ISO NMS-873 results in decreased expression of FASN mRNA CTD PMID:35430252 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO NMS-873 results in increased expression of HSPA5 protein CTD PMID:23892893 PMID:29693262 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il6 interleukin 6 multiple interactions ISO NMS-873 inhibits the reaction [IL6 protein results in increased expression of KLK3 protein] CTD PMID:29693262 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions ISO NMS-873 inhibits the reaction [IL6 protein results in increased expression of KLK3 protein] CTD PMID:29693262 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases stability ISO NMS-873 results in increased stability of MCL1 protein CTD PMID:23892893 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 decreases metabolic processing ISO NMS-873 results in decreased metabolism of NFKB2 protein CTD PMID:28190248 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor multiple interactions ISO NMS-873 promotes the reaction [NPLOC4 protein binds to VCP protein] CTD PMID:27105284 NCBI chr10:106,152,756...106,208,306
Ensembl chr10:105,654,812...105,709,913
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO NMS-873 results in increased cleavage of PARP1 protein CTD PMID:23892893 PMID:29693262 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO NMS-873 results in increased expression of PPP1R15A protein CTD PMID:23892893 NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO NMS-873 results in decreased expression of SCD mRNA CTD PMID:35430252 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO NMS-873 results in decreased expression of SNAI1 protein CTD PMID:29693262 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO NMS-873 results in decreased expression of SNAI2 protein CTD PMID:29693262 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO NMS-873 results in decreased expression of SREBF1 protein CTD PMID:35430252 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tp53 tumor protein p53 increases expression ISO NMS-873 results in increased expression of TP53 protein CTD PMID:29693262 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 multiple interactions ISO NMS-873 promotes the reaction [UFD1 protein binds to VCP protein] CTD PMID:27105284 NCBI chr11:95,665,971...95,689,423
Ensembl chr11:82,161,619...82,185,087
JBrowse link
G Vcp valosin-containing protein decreases response to substance
multiple interactions
decreases activity
increases ubiquitination
ISO VCP gene SNP results in decreased susceptibility to NMS-873; VCP protein mutant form results in decreased susceptibility to NMS-873
NMS-873 promotes the reaction [AMFR protein binds to VCP protein]; NMS-873 promotes the reaction [FAF1 protein binds to VCP protein]; NMS-873 promotes the reaction [FAF2 protein binds to VCP protein]; NMS-873 promotes the reaction [NPLOC4 protein binds to VCP protein]; NMS-873 promotes the reaction [UFD1 protein binds to VCP protein]
NMS-873 results in decreased activity of VCP protein
NMS-873 results in increased ubiquitination of VCP protein
CTD PMID:23892893 PMID:24878061 PMID:27105284 PMID:27434122 NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
G Vim vimentin decreases expression ISO NMS-873 results in decreased expression of VIM protein CTD PMID:29693262 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19820
          carbon atom 19772
            organic molecular entity 19772
              NMS-873 35
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      p-block molecular entity 19836
                        carbon group molecular entity 19776
                          organic molecular entity 19772
                            NMS-873 35
paths to the root