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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:NMS-873
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Accession:CHEBI:232809 term browser browse the term
Synonyms:related_synonym: 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine
 xref: CAS:1418013-75-8
 xref_mesh: MESH:C000623013
 xref: pubmed:28322724
 chemrof_formula: C27H28N4O3S2
 chemrof_smiles: Cc1cc(OCc2nnc(SC3CCCC3)n2-c2cccnc2)ccc1-c1ccc(S(C)(=O)=O)cc1
 chemrof_inchi: InChI=1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2,32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6,9-17,23H,3-4,7-8,18H2,1-2H3
 chemrof_inchikey: UJGTUKMAJVCBIS-UHFFFAOYSA-N


show annotations for term's descendants           Sort by:
NMS-873 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor multiple interactions ISO NMS-873 promotes the reaction [AMFR protein binds to VCP protein] CTD PMID:27105284 NCBI chr19:11,002,451...11,038,182
Ensembl chr19:11,002,101...11,038,364 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO NMS-873 results in increased expression of BAX protein CTD PMID:29693262 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO NMS-873 results in decreased expression of BCL2 protein CTD PMID:29693262 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Canx calnexin increases expression ISO NMS-873 results in increased expression of CANX protein CTD PMID:29693262 NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity 		ISO NMS-873 results in increased cleavage of CASP3 protein
NMS-873 results in increased activity of CASP3 protein 		CTD PMID:23892893 PMID:27434122 PMID:29693262 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases activity ISO NMS-873 results in increased activity of CASP7 protein CTD PMID:27434122 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 increases activity ISO NMS-873 results in increased activity of CASP9 protein CTD PMID:29693262 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccne1 cyclin E1 increases stability ISO NMS-873 results in increased stability of CCNE1 protein CTD PMID:23892893 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Cdh1 cadherin 1 decreases expression ISO NMS-873 results in decreased expression of CDH1 protein CTD PMID:29693262 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO NMS-873 results in decreased expression of CDH2 protein CTD PMID:29693262 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO NMS-873 results in increased expression of CDKN1A protein CTD PMID:29693262 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO NMS-873 results in increased expression of CDKN1B protein CTD PMID:29693262 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO NMS-873 results in increased expression of DDIT3 protein CTD PMID:23892893 PMID:29693262 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO NMS-873 results in increased expression of EIF2AK3 protein CTD PMID:29693262 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO NMS-873 results in increased expression of ERN1 protein CTD PMID:29693262 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO NMS-873 results in increased expression of ERO1A protein CTD PMID:29693262 NCBI chr15:20,974,771...21,010,170
Ensembl chr15:20,972,679...21,018,039 		JBrowse link
G Faf1 Fas associated factor 1 multiple interactions ISO NMS-873 promotes the reaction [FAF1 protein binds to VCP protein] CTD PMID:27105284 NCBI chr 5:129,654,677...130,018,604
Ensembl chr 5:129,654,445...130,020,516 		JBrowse link
G Faf2 Fas associated factor family member 2 multiple interactions ISO NMS-873 promotes the reaction [FAF2 protein binds to VCP protein] CTD PMID:27105284 NCBI chr17:9,952,329...9,994,596
Ensembl chr17:9,952,329...9,994,711 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO NMS-873 results in decreased expression of FASN mRNA CTD PMID:35430252 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO NMS-873 results in increased expression of HSPA5 protein CTD PMID:23892893 PMID:29693262 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO NMS-873 inhibits the reaction [IL6 protein results in increased expression of KLK3 protein] CTD PMID:29693262 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions ISO NMS-873 inhibits the reaction [IL6 protein results in increased expression of KLK3 protein] CTD PMID:29693262 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases stability ISO NMS-873 results in increased stability of MCL1 protein CTD PMID:23892893 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 decreases metabolic processing ISO NMS-873 results in decreased metabolism of NFKB2 protein CTD PMID:28190248 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor multiple interactions ISO NMS-873 promotes the reaction [NPLOC4 protein binds to VCP protein] CTD PMID:27105284 NCBI chr10:106,152,756...106,208,306
Ensembl chr10:106,153,173...106,208,264 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO NMS-873 results in increased cleavage of PARP1 protein CTD PMID:23892893 PMID:29693262 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO NMS-873 results in increased expression of PPP1R15A protein CTD PMID:23892893 NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO NMS-873 results in decreased expression of SCD mRNA CTD PMID:35430252 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO NMS-873 results in decreased expression of SNAI1 protein CTD PMID:29693262 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO NMS-873 results in decreased expression of SNAI2 protein CTD PMID:29693262 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO NMS-873 results in decreased expression of SREBF1 protein CTD PMID:35430252 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO NMS-873 results in increased expression of TP53 protein CTD PMID:29693262 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 multiple interactions ISO NMS-873 promotes the reaction [UFD1 protein binds to VCP protein] CTD PMID:27105284 NCBI chr11:95,665,971...95,689,423
Ensembl chr11:95,665,972...95,689,434 		JBrowse link
G Vcp valosin-containing protein decreases response to substance
multiple interactions
decreases activity
increases ubiquitination 		ISO VCP gene SNP results in decreased susceptibility to NMS-873; VCP protein mutant form results in decreased susceptibility to NMS-873
NMS-873 promotes the reaction [AMFR protein binds to VCP protein]; NMS-873 promotes the reaction [FAF1 protein binds to VCP protein]; NMS-873 promotes the reaction [FAF2 protein binds to VCP protein]; NMS-873 promotes the reaction [NPLOC4 protein binds to VCP protein]; NMS-873 promotes the reaction [UFD1 protein binds to VCP protein]
NMS-873 results in decreased activity of VCP protein
NMS-873 results in increased ubiquitination of VCP protein 		CTD PMID:23892893 PMID:24878061 PMID:27105284 PMID:27434122 NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:62,005,985...62,025,387 		JBrowse link
G Vim vimentin decreases expression ISO NMS-873 results in decreased expression of VIM protein CTD PMID:29693262 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      atom 20872
        nonmetal atom 20781
          carbon atom 20706
            organic molecular entity 20706
              NMS-873 35
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      p-block molecular entity 20796
                        carbon group molecular entity 20724
                          organic molecular entity 20706
                            NMS-873 35
paths to the root