CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: NMS-873
Accession: CHEBI:232809
browse the term
Synonyms: exact_synonym: 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine
related_synonym: Formula=C27H28N4O3S2; InChI=1S/C27H28N4O3S2/c1-19-16-22(11-14-25(19)20-9-12-24(13-10-20)36(2,32)33)34-18-26-29-30-27(35-23-7-3-4-8-23)31(26)21-6-5-15-28-17-21/h5-6,9-17,23H,3-4,7-8,18H2,1-2H3; InChIKey=UJGTUKMAJVCBIS-UHFFFAOYSA-N; SMILES=CC1=CC(=CC=C1C2=CC=C(C=C2)S(C)(=O)=O)OCC3=NN=C(N3C=4C=CC=NC4)SC5CCCC5
xref: CAS:1418013-75-8
xref_mesh: MESH:C000623013
xref: PMID:28322724
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Amfr
autocrine motility factor receptor
multiple interactions
ISO
NMS-873 promotes the reaction [AMFR protein binds to VCP protein]
CTD
PMID:27105284
NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
NMS-873 results in increased expression of BAX protein
CTD
PMID:29693262
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
NMS-873 results in decreased expression of BCL2 protein
CTD
PMID:29693262
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Canx
calnexin
increases expression
ISO
NMS-873 results in increased expression of CANX protein
CTD
PMID:29693262
NCBI chr10:35,124,941...35,157,954
Ensembl chr10:34,625,191...34,656,821
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Casp3
caspase 3
increases cleavage increases activity
ISO
NMS-873 results in increased cleavage of CASP3 protein NMS-873 results in increased activity of CASP3 protein
CTD
PMID:23892893 PMID:27434122 PMID:29693262
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
increases activity
ISO
NMS-873 results in increased activity of CASP7 protein
CTD
PMID:27434122
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
increases activity
ISO
NMS-873 results in increased activity of CASP9 protein
CTD
PMID:29693262
Ensembl chr 5:154,109,046...154,126,626
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Ccne1
cyclin E1
increases stability
ISO
NMS-873 results in increased stability of CCNE1 protein
CTD
PMID:23892893
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
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Cdh1
cadherin 1
decreases expression
ISO
NMS-873 results in decreased expression of CDH1 protein
CTD
PMID:29693262
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
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Cdh2
cadherin 2
decreases expression
ISO
NMS-873 results in decreased expression of CDH2 protein
CTD
PMID:29693262
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
NMS-873 results in increased expression of CDKN1A protein
CTD
PMID:29693262
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
NMS-873 results in increased expression of CDKN1B protein
CTD
PMID:29693262
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
NMS-873 results in increased expression of DDIT3 protein
CTD
PMID:23892893 PMID:29693262
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases expression
ISO
NMS-873 results in increased expression of EIF2AK3 protein
CTD
PMID:29693262
NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
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Ern1
endoplasmic reticulum to nucleus signaling 1
increases expression
ISO
NMS-873 results in increased expression of ERN1 protein
CTD
PMID:29693262
NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
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Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
increases expression
ISO
NMS-873 results in increased expression of ERO1A protein
CTD
PMID:29693262
NCBI chr15:20,974,771...21,010,170
Ensembl chr15:18,492,945...18,530,478
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Faf1
Fas associated factor 1
multiple interactions
ISO
NMS-873 promotes the reaction [FAF1 protein binds to VCP protein]
CTD
PMID:27105284
NCBI chr 5:129,654,677...130,018,604
Ensembl chr 5:124,426,062...124,789,977
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Faf2
Fas associated factor family member 2
multiple interactions
ISO
NMS-873 promotes the reaction [FAF2 protein binds to VCP protein]
CTD
PMID:27105284
NCBI chr17:9,952,329...9,994,596
Ensembl chr17:9,947,220...9,989,485
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Fasn
fatty acid synthase
decreases expression
ISO
NMS-873 results in decreased expression of FASN mRNA
CTD
PMID:35430252
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
NMS-873 results in increased expression of HSPA5 protein
CTD
PMID:23892893 PMID:29693262
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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Il6
interleukin 6
multiple interactions
ISO
NMS-873 inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]
CTD
PMID:29693262
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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Klk1c10
kallikrein 1-related peptidase C10
multiple interactions
ISO
NMS-873 inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]
CTD
PMID:29693262
NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
increases stability
ISO
NMS-873 results in increased stability of MCL1 protein
CTD
PMID:23892893
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
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Nfkb2
nuclear factor kappa B subunit 2
decreases metabolic processing
ISO
NMS-873 results in decreased metabolism of NFKB2 protein
CTD
PMID:28190248
NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:245,165,950...245,173,213
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Nploc4
NPL4 homolog, ubiquitin recognition factor
multiple interactions
ISO
NMS-873 promotes the reaction [NPLOC4 protein binds to VCP protein]
CTD
PMID:27105284
NCBI chr10:106,152,756...106,208,306
Ensembl chr10:105,654,812...105,709,913
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
NMS-873 results in increased cleavage of PARP1 protein
CTD
PMID:23892893 PMID:29693262
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
ISO
NMS-873 results in increased expression of PPP1R15A protein
CTD
PMID:23892893
NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:96,000,058...96,003,171
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Scd
stearoyl-CoA desaturase
decreases expression
ISO
NMS-873 results in decreased expression of SCD mRNA
CTD
PMID:35430252
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
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Snai1
snail family transcriptional repressor 1
decreases expression
ISO
NMS-873 results in decreased expression of SNAI1 protein
CTD
PMID:29693262
NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
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Snai2
snail family transcriptional repressor 2
decreases expression
ISO
NMS-873 results in decreased expression of SNAI2 protein
CTD
PMID:29693262
NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
ISO
NMS-873 results in decreased expression of SREBF1 protein
CTD
PMID:35430252
NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
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Tp53
tumor protein p53
increases expression
ISO
NMS-873 results in increased expression of TP53 protein
CTD
PMID:29693262
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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Ufd1
ubiquitin recognition factor in ER associated degradation 1
multiple interactions
ISO
NMS-873 promotes the reaction [UFD1 protein binds to VCP protein]
CTD
PMID:27105284
NCBI chr11:95,665,971...95,689,423
Ensembl chr11:82,161,619...82,185,087
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Vcp
valosin-containing protein
decreases response to substance multiple interactions decreases activity increases ubiquitination
ISO
VCP gene SNP results in decreased susceptibility to NMS-873; VCP protein mutant form results in decreased susceptibility to NMS-873 NMS-873 promotes the reaction [AMFR protein binds to VCP protein]; NMS-873 promotes the reaction [FAF1 protein binds to VCP protein]; NMS-873 promotes the reaction [FAF2 protein binds to VCP protein]; NMS-873 promotes the reaction [NPLOC4 protein binds to VCP protein]; NMS-873 promotes the reaction [UFD1 protein binds to VCP protein] NMS-873 results in decreased activity of VCP protein NMS-873 results in increased ubiquitination of VCP protein
CTD
PMID:23892893 PMID:24878061 PMID:27105284 PMID:27434122
NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:57,210,168...57,229,571
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Vim
vimentin
decreases expression
ISO
NMS-873 results in decreased expression of VIM protein
CTD
PMID:29693262
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
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