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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,5-dimethylcelecoxib
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Accession:CHEBI:232608 term browser browse the term
Synonyms:related_synonym: Formula=C18H16F3N3O2S;   InChI=1S/C18H16F3N3O2S/c1-11-3-4-12(2)15(9-11)16-10-17(18(19,20)21)23-24(16)13-5-7-14(8-6-13)27(22,25)26/h3-10H,1-2H3,(H2,22,25,26);   InChIKey=NTFOSUUWGCDXEF-UHFFFAOYSA-N;   SMILES=CC=1C=CC(C)=C(C1)C2=CC(C(F)(F)F)=NN2C3=CC=C(C=C3)S(N)(=O)=O
 xref: CAS:457639-26-8;   HMDB:HMDB0245502
 xref_mesh: MESH:C506698
 xref: PMID:28025308



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2,5-dimethylcelecoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO 2,5-dimethylcelecoxib results in decreased expression of BIRC5 protein CTD PMID:16123214 PMID:16707021 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2,5-dimethylcelecoxib results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:16123214 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO 2,5-dimethylcelecoxib results in increased activity of CASP7 protein CTD PMID:18485224 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 2,5-dimethylcelecoxib results in increased expression of DDIT3 protein CTD PMID:18485224 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 2,5-dimethylcelecoxib inhibits the reaction [IL6 protein results in increased phosphorylation of MAP2K1 protein]; 2,5-dimethylcelecoxib inhibits the reaction [IL6 protein results in increased phosphorylation of MAP2K2 protein]; 2,5-dimethylcelecoxib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein] CTD PMID:16123214 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases phosphorylation
multiple interactions
ISO 2,5-dimethylcelecoxib results in decreased phosphorylation of MAP2K1 protein
2,5-dimethylcelecoxib inhibits the reaction [IL6 protein results in increased phosphorylation of MAP2K1 protein]
CTD PMID:16123214 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases phosphorylation
multiple interactions
ISO 2,5-dimethylcelecoxib results in decreased phosphorylation of MAP2K2 protein
2,5-dimethylcelecoxib inhibits the reaction [IL6 protein results in increased phosphorylation of MAP2K2 protein]
CTD PMID:16123214 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO 2,5-dimethylcelecoxib results in increased cleavage of PARP1 protein CTD PMID:16123214 PMID:18485224 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 2,5-dimethylcelecoxib inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein] CTD PMID:16123214 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19820
          carbon atom 19772
            organic molecular entity 19772
              2,5-dimethylcelecoxib 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      p-block molecular entity 19836
                        carbon group molecular entity 19776
                          organic molecular entity 19772
                            2,5-dimethylcelecoxib 9
paths to the root