The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Erdafitinib is a Kinase Inhibitor. The mechanism of action of erdafitinib is as a Fibroblast Growth Factor Receptor Inhibitor, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A4 Inducer, and P-Glycoprotein Inhibitor, and Organic Cation Transporter 2 Inhibitor.
erdafitinib results in decreased activity of CYP3A4 protein CYP3A4 protein results in increased metabolism of erdafitinib erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Rivaroxaban]; erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A4 protein]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]]; Testosterone inhibits the reaction [erdafitinib results in decreased activity of CYP3A4 protein]
erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; erdafitinib inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Midazolam]; erdafitinib inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Rivaroxaban]; erdafitinib inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A5 protein]; Testosterone inhibits the reaction [erdafitinib results in decreased activity of CYP3A5 protein] CYP3A5 protein results in increased metabolism of erdafitinib