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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:CL316243
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Accession:CHEBI:232554 term browser browse the term
Definition:CL316243 is a highly potent selective beta-3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to beta1/2- receptors.
Synonyms:related_synonym: CL 316,243;   CL-316243;   Disodium 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate hydrate;   Formula=C20H18ClNNa2O7;   InChI=1S/C20H20ClNO7.2Na/c1-11(22-10-15(23)13-3-2-4-14(21)9-13)7-12-5-6-16-17(8-12)29-20(28-16,18(24)25)19(26)27;;/h2-6,8-9,11,15,22-23H,7,10H2,1H3,(H,24,25)(H,26,27);;/q;2*+1/p-2/t11-,15+;;/m1../s1;   InChIKey=FUZBPOHHSBDTJQ-CFOQQKEYSA-L;   SMILES=O=C(C1(C(O[Na])=O)OC2=CC=C(C[C@H](NC[C@@H](C3=CC=CC(Cl)=C3)O)C)C=C2O1)O[Na]
 xref: CAS:138908-40-4
 xref_mesh: MESH:C076126



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CL316243 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of ACACA mRNA CTD PMID:20184727 NCBI chr10:69,511,627...69,773,888 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of ADIPOQ mRNA CTD PMID:20184727 NCBI chr11:91,226,524...91,240,244 JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
decreases expression
increases expression
ISO
EXP
[3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate results in increased expression of ADRB3 mRNA] which results in increased susceptibility to disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate; disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate binds to and results in increased activity of ADRB3 protein; disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate inhibits the reaction [Rosiglitazone results in increased expression of ADRB3 mRNA]
disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in decreased expression of ADRB3 mRNA
disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of ADRB3 mRNA
CTD PMID:7815362 PMID:10725275 PMID:11275008 PMID:16399693 PMID:18651730 More... NCBI chr16:64,839,820...64,844,552 JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression
multiple interactions
EXP
ISO
disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of CPT1B mRNA
disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate promotes the reaction [Rosiglitazone results in increased expression of CPT1B mRNA]
CTD PMID:20184727 PMID:29910772 NCBI chr 7:120,491,354...120,500,833 JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of FABP4 mRNA CTD PMID:20184727 NCBI chr 2:93,488,251...93,492,961 JBrowse link
G Fasn fatty acid synthase increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of FASN mRNA CTD PMID:20184727 NCBI chr10:106,570,415...106,588,581 JBrowse link
G Gk glycerol kinase increases activity EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased activity of GK protein CTD PMID:12736183 NCBI chr  X:54,106,708...54,189,940 JBrowse link
G Ide insulin degrading enzyme increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of IDE mRNA CTD PMID:20184727 NCBI chr 1:244,415,495...244,516,925 JBrowse link
G Insr insulin receptor increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of INSR mRNA CTD PMID:20184727 NCBI chr12:5,991,135...6,129,275 JBrowse link
G Irs1 insulin receptor substrate 1 increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of IRS1 mRNA CTD PMID:20184727 NCBI chr 9:91,001,137...91,053,959 JBrowse link
G Lipe lipase E, hormone sensitive type increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of LIPE mRNA CTD PMID:20184727 NCBI chr 1:80,965,612...80,984,313 JBrowse link
G Lpl lipoprotein lipase increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of LPL mRNA CTD PMID:20184727 NCBI chr16:25,596,205...25,621,928 JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of NAMPT mRNA CTD PMID:20184727 NCBI chr 6:55,152,756...55,189,547 JBrowse link
G Pde3b phosphodiesterase 3B increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of PDE3B mRNA CTD PMID:20184727 NCBI chr 1:168,606,762...168,770,078 JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of PNPLA3 mRNA CTD PMID:20184727 NCBI chr 7:115,293,538...115,314,077 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of PPARA mRNA CTD PMID:20184727 NCBI chr 7:118,712,261...118,780,723 JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of PPARD mRNA CTD PMID:20184727 NCBI chr20:6,300,527...6,365,707 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of PPARG mRNA; disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of PPARG mRNA alternative form CTD PMID:20184727 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Retn resistin increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of RETN mRNA CTD PMID:20184727 NCBI chr12:6,508,653...6,511,115 JBrowse link
G Slc27a1 solute carrier family 27 member 1 increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of SLC27A1 mRNA CTD PMID:20184727 NCBI chr16:18,278,984...18,300,173 JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of SLC2A4 mRNA CTD PMID:20184727 NCBI chr10:55,164,721...55,170,289 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of SREBF1 mRNA CTD PMID:20184727 NCBI chr10:45,507,152...45,529,164 JBrowse link
G Tnf tumor necrosis factor increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of TNF mRNA CTD PMID:20184727 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Ucp1 uncoupling protein 1 increases expression
multiple interactions
ISO
EXP
disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of UCP1 mRNA
[Rosiglitazone results in increased susceptibility to disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate] which results in increased expression of UCP1 mRNA; [Rosiglitazone results in increased susceptibility to disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate] which results in increased expression of UCP1 protein; disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate promotes the reaction [Rosiglitazone results in increased expression of UCP1 mRNA]; disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate promotes the reaction [Rosiglitazone results in increased expression of UCP1 protein]
CTD PMID:20184727 PMID:29910772 NCBI chr19:41,713,350...41,721,421 JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of UCP2 mRNA CTD PMID:20184727 NCBI chr 1:164,251,373...164,257,742 JBrowse link
G Ucp3 uncoupling protein 3 increases expression EXP disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of UCP3 mRNA CTD PMID:20184727 NCBI chr 1:154,815,777...154,828,764 JBrowse link

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  CHEBI ontology 19898
    chemical entity 19896
      atom 19896
        nonmetal atom 19818
          carbon atom 19770
            organic molecular entity 19770
              CL316243 26
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
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              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            CL316243 26
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