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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imisopasem manganese
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Accession:CHEBI:232553 term browser browse the term
Synonyms:related_synonym: Formula=C21H35N5.Cl.Cl.Mn;   InChI=1S/C21H35N5.2ClH.Mn/c1-3-10-20-18(8-1)22-12-13-23-19-9-2-4-11-21(19)25-15-17-7-5-6-16(26-17)14-24-20;;;/h5-7,18-25H,1-4,8-15H2;2*1H;/q;;;+2/p-2/t18-,19-,20-,21-;;;/m1.../s1;   InChIKey=WXEMWBBXVXHEPU-XNPJUPKFSA-L;   M40403;   SMILES=C1CC[C@@]2([C@](C1)([H])NCCN[C@@]3(CCCC[C@@]3([H])NCC4=CC=CC(CN2)=N4)[H])[H].[Cl-].[Cl-].[Mn+2];   Unii-2Q6R3259KS
 xref: CAS:218791-21-0;   KEGG:D06607
 xref_mesh: MESH:C121876



show annotations for term's descendants           Sort by:
imisopasem manganese term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E multiple interactions
decreases response to substance
ISO imisopasem manganese inhibits the reaction [APOE gene mutant form results in increased chemical synthesis of Superoxides]
imisopasem manganese results in decreased susceptibility to APOE gene mutant form
CTD PMID:12871831 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of ATP2A1 protein] CTD PMID:28483572 NCBI chr 1:190,457,198...190,475,410
Ensembl chr 1:181,026,608...181,044,838
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression
multiple interactions
EXP imisopasem manganese results in decreased expression of ATP2A2 protein
imisopasem manganese inhibits the reaction [imisopasem manganese results in decreased expression of ATP2A2 protein]
CTD PMID:28483572 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression EXP imisopasem manganese results in increased expression of ATP5F1B protein CTD PMID:28483572 NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:515,460...567,273
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions
increases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of COX4I1 protein]
imisopasem manganese results in increased expression of COX4I1 protein
CTD PMID:28483572 NCBI chr19:65,630,383...65,636,623
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP imisopasem manganese inhibits the reaction [Carrageenan results in increased expression of ICAM1 protein] CTD PMID:11181422 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP imisopasem manganese inhibits the reaction [Carrageenan results in increased expression of IL1B protein] CTD PMID:11181422 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP imisopasem manganese inhibits the reaction [Carrageenan results in increased expression of IL6 protein] CTD PMID:11181422 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mfn2 mitofusin 2 decreases expression
multiple interactions
EXP imisopasem manganese results in decreased expression of MFN2 protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of MFN2 protein]
CTD PMID:28483572 NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 multiple interactions
decreases expression
EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of NDUFA9 protein]
imisopasem manganese results in decreased expression of NDUFA9 protein
CTD PMID:28483572 NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression
EXP Alloxan affects the reaction [imisopasem manganese results in increased expression of NRF1 protein] CTD PMID:28483572 NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions
EXP imisopasem manganese results in decreased expression of PPARGC1A protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of PPARGC1A protein]
CTD PMID:28483572 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions EXP imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SDHA protein] CTD PMID:28483572 NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Selp selectin P multiple interactions EXP imisopasem manganese inhibits the reaction [Carrageenan results in increased expression of SELP protein] CTD PMID:11181422 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
multiple interactions
EXP imisopasem manganese results in increased expression of SLC2A4 protein
imisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SLC2A4 protein]
CTD PMID:28483572 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP imisopasem manganese inhibits the reaction [Carrageenan results in increased expression of TNF protein] CTD PMID:11181422 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 increases expression
multiple interactions
EXP imisopasem manganese results in increased expression of UQCRC2 protein
imisopasem manganese promotes the reaction [Alloxan results in increased expression of UQCRC2 protein]
CTD PMID:28483572 NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:175,167,894...175,199,453
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19879
    role 19850
      application 19693
        enzyme mimic 74
          imisopasem manganese 17
Path 2
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  CHEBI ontology 19879
    subatomic particle 19877
      composite particle 19877
        hadron 19877
          baryon 19877
            nucleon 19877
              atomic nucleus 19877
                atom 19877
                  main group element atom 19816
                    main group molecular entity 19816
                      p-block molecular entity 19816
                        carbon group molecular entity 19756
                          organic molecular entity 19753
                            imisopasem manganese 17
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