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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diphenyl diselenide
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Accession:CHEBI:232541 term browser browse the term
Synonyms:related_synonym: Formula=C12H10Se2;   InChI=1S/C12H10Se2/c1-3-7-11(8-4-1)13-14-12-9-5-2-6-10-12/h1-10H;   InChIKey=YWWZCHLUQSHMCL-UHFFFAOYSA-N;   SMILES=C1=CC=C(C=C1)[Se][Se]C2=CC=CC=C2
 xref: CAS:1666-13-3
 xref_mesh: MESH:C061132
 xref: PMID:38518983;   Wikipedia:https://en.wikipedia.org/wiki/Diphenyl_diselenide



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diphenyl diselenide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP diphenyldiselenide inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein] CTD PMID:30267645 NCBI chr12:25,042,882...25,050,608 JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP diphenyldiselenide inhibits the reaction [2-nitropropane results in increased expression of AFP protein] CTD PMID:15804453 NCBI chr14:17,573,412...17,591,476 JBrowse link
G Alad aminolevulinate dehydratase decreases activity
multiple interactions
EXP
ISO
diphenyldiselenide results in decreased activity of ALAD protein
[diphenyldiselenide co-treated with Succimer] inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]; [Mercuric Chloride co-treated with diphenyldiselenide] results in decreased activity of ALAD protein; Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]; diphenyldiselenide inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]; diphenyldiselenide inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]; Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]
[diphenyldiselenide co-treated with diphenyldiselenide] results in decreased activity of ALAD protein; [Fluphenazine co-treated with diphenyldiselenide] results in decreased activity of ALAD protein; diphenyldiselenide inhibits the reaction [Glycerol results in decreased activity of ALAD protein]; Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]
CTD PMID:15331134 PMID:16000234 PMID:17822862 PMID:17975852 PMID:18804525 More... NCBI chr 5:75,961,993...75,972,334 JBrowse link
G Alb albumin multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of ALB protein] CTD PMID:33639173 NCBI chr14:17,891,564...17,907,043 JBrowse link
G B2m beta-2 microglobulin multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in increased activity of B2M protein]; diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of B2M protein] CTD PMID:33639173 NCBI chr 3:129,549,236...129,555,354 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO diphenyldiselenide inhibits the reaction [methylmercuric chloride results in decreased expression of BDNF protein] CTD PMID:23954720 NCBI chr 3:116,619,633...116,670,212 JBrowse link
G Cat catalase multiple interactions
increases activity
decreases activity
ISO
EXP
[Mercuric Chloride co-treated with diphenyldiselenide] results in decreased activity of CAT protein; diphenyldiselenide inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]
diphenyldiselenide results in increased activity of CAT protein
diphenyldiselenide results in decreased activity of CAT protein
[diphenyldiselenide co-treated with diphenyldiselenide] promotes the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; diphenyldiselenide inhibits the reaction [2-nitropropane results in decreased activity of CAT protein]; diphenyldiselenide inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; diphenyldiselenide inhibits the reaction [Fluphenazine results in increased activity of CAT protein]; diphenyldiselenide inhibits the reaction [Glycerol results in decreased activity of CAT protein]; diphenyldiselenide inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of CAT mRNA]; Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of CAT protein]
CTD PMID:16445897 PMID:17822862 PMID:18818063 PMID:18989868 PMID:19484701 More... NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA] CTD PMID:33639173 NCBI chr10:67,503,077...67,504,875 JBrowse link
G Cs citrate synthase multiple interactions EXP diphenyldiselenide inhibits the reaction [Cisplatin results in decreased activity of CS protein] CTD PMID:32860823 NCBI chr 7:1,348,389...1,374,624 JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions EXP diphenyldiselenide inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CXCR2 mRNA] CTD PMID:36174737 NCBI chr 9:75,729,493...75,735,868 JBrowse link
G Eno2 enolase 2 multiple interactions EXP diphenyldiselenide inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of ENO2 mRNA] CTD PMID:36174737 NCBI chr 4:159,258,371...159,267,220 JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP diphenyldiselenide inhibits the reaction [acephate results in increased activity of G6PC1 protein]; diphenyldiselenide inhibits the reaction [Cisplatin results in increased activity of G6PC1 protein] CTD PMID:22778074 PMID:32860823 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of GCLC mRNA]; diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of GCLC protein] CTD PMID:33639173 NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions
EXP diphenyldiselenide results in decreased expression of GFAP protein
diphenyldiselenide inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of GFAP mRNA]
CTD PMID:19926633 PMID:36174737 NCBI chr10:88,352,987...88,361,661 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP [diphenyldiselenide co-treated with diphenyldiselenide] promotes the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
diphenyldiselenide results in increased activity of GPT protein
CTD PMID:17975852 PMID:18989868 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA] CTD PMID:33639173 NCBI chr 8:117,905,462...117,906,588 JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO diphenyldiselenide inhibits the reaction [bisphenol A results in decreased expression of GRIN2A protein] CTD PMID:28572023 NCBI chr10:6,136,458...6,560,003 JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO diphenyldiselenide inhibits the reaction [bisphenol A results in decreased expression of GRIN2B protein] CTD PMID:28572023 NCBI chr 4:170,297,811...170,775,420 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of HMOX1 mRNA]; diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein]; diphenyldiselenide promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA] CTD PMID:33639173 PMID:36174737 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Il10 interleukin 10 multiple interactions EXP diphenyldiselenide inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of IL10 mRNA]; diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of IL10 protein] CTD PMID:33639173 PMID:36174737 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA] CTD PMID:33639173 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il6 interleukin 6 multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of IL6 protein] CTD PMID:33639173 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA]; diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein] CTD PMID:33639173 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
diphenyldiselenide inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]
diphenyldiselenide results in decreased phosphorylation of MAPK1 protein
diphenyldiselenide results in increased phosphorylation of MAPK1 protein
CTD PMID:20924558 PMID:33639173 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
diphenyldiselenide inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]
diphenyldiselenide results in decreased phosphorylation of MAPK3 protein
diphenyldiselenide results in increased phosphorylation of MAPK3 protein
CTD PMID:20924558 PMID:33639173 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP diphenyldiselenide inhibits the reaction [Chlorpyrifos results in increased activity of MPO protein] CTD PMID:30267645 NCBI chr10:73,092,124...73,102,057 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; diphenyldiselenide promotes the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA] CTD PMID:33639173 PMID:36174737 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP diphenyldiselenide inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NFKB1 mRNA] CTD PMID:36174737 NCBI chr 2:226,689,745...226,805,897 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in increased activity of NOS2 protein] CTD PMID:33639173 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of NQO1 mRNA]; diphenyldiselenide inhibits the reaction [Streptozocin results in decreased expression of NQO1 protein] CTD PMID:33639173 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Slc17a7 solute carrier family 17 member 7 decreases expression EXP diphenyldiselenide results in decreased expression of SLC17A7 protein CTD PMID:19926633 NCBI chr 1:95,649,709...95,661,591 JBrowse link
G Slc1a1 solute carrier family 1 member 1 increases expression EXP diphenyldiselenide results in increased expression of SLC1A1 protein CTD PMID:19926633 NCBI chr 1:226,549,932...226,631,925 JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases expression EXP diphenyldiselenide results in increased expression of SLC1A3 protein CTD PMID:19926633 NCBI chr 2:57,755,495...57,830,605 JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP diphenyldiselenide inhibits the reaction [Cisplatin results in increased expression of SLC2A2 protein] CTD PMID:32860823 NCBI chr 2:113,537,884...113,568,422 JBrowse link
G Snap25 synaptosome associated protein 25 decreases expression EXP diphenyldiselenide results in decreased expression of SNAP25 protein CTD PMID:19926633 NCBI chr 3:144,494,579...144,576,449 JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP diphenyldiselenide inhibits the reaction [acephate results in increased activity of TAT protein]; diphenyldiselenide inhibits the reaction [Cisplatin results in increased activity of TAT protein] CTD PMID:22778074 PMID:32860823 NCBI chr19:37,947,153...37,957,717 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP diphenyldiselenide inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TNF mRNA]; diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:33639173 PMID:36174737 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases response to substance
multiple interactions
ISO TXNRD1 gene mutant form results in decreased susceptibility to diphenyldiselenide
TXNRD1 gene mutant form inhibits the reaction [diphenyldiselenide results in increased abundance of Cysteine]
diphenyldiselenide results in increased expression of and affects the localization of TXNRD1 protein
CTD PMID:23360449 NCBI chr 7:22,717,620...22,802,553 JBrowse link

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                            diphenyl diselenide 38
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