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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:PF-4708671
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Accession:CHEBI:232526 term browser browse the term
Synonyms:related_synonym: 2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole;   Formula=C19H21F3N6;   InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26);   InChIKey=FBLPQCAQRNSVHB-UHFFFAOYSA-N;   SMILES=CCC1=CN=CN=C1N2CCN(CC2)CC3=NC=4C=CC(=CC4N3)C(F)(F)F
 xref: CAS:1255517-76-0
 xref_mesh: MESH:C552719
 xref: PMID:20704563


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PF-4708671 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [NVP-BSK805 co-treated with PF-4708671] results in increased expression of BBC3 protein CTD PMID:26242912 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO [NVP-BSK805 co-treated with PF-4708671] results in increased expression of BCL2L11 protein modified form CTD PMID:26242912 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP PF-4708671 promotes the reaction [Isoflurane results in increased cleavage of CASP3 protein] CTD PMID:25597859 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP PF-4708671 promotes the reaction [Isoflurane results in decreased expression of DLG4 protein] CTD PMID:25597859 NCBI chr10:55,239,397...55,267,780
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        inhibitor 18967
          PF-4708671 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      p-block molecular entity 19846
                        carbon group molecular entity 19784
                          organic molecular entity 19781
                            PF-4708671 4
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