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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:PF-4708671
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Accession:CHEBI:232526 term browser browse the term
Synonyms:related_synonym: 2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole;   Formula=C19H21F3N6;   InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26);   InChIKey=FBLPQCAQRNSVHB-UHFFFAOYSA-N;   SMILES=CCC1=CN=CN=C1N2CCN(CC2)CC3=NC=4C=CC(=CC4N3)C(F)(F)F
 xref: CAS:1255517-76-0
 xref_mesh: MESH:C552719
 xref: PMID:20704563



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PF-4708671 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [NVP-BSK805 co-treated with PF-4708671] results in increased expression of BBC3 protein CTD PMID:26242912 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO [NVP-BSK805 co-treated with PF-4708671] results in increased expression of BCL2L11 protein modified form CTD PMID:26242912 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Casp3 caspase 3 multiple interactions EXP PF-4708671 promotes the reaction [Isoflurane results in increased cleavage of CASP3 protein] CTD PMID:25597859 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP PF-4708671 promotes the reaction [Isoflurane results in decreased expression of DLG4 protein] CTD PMID:25597859 NCBI chr10:55,239,397...55,267,780
Ensembl chr10:54,739,470...54,767,153
JBrowse link

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  CHEBI ontology 19879
    role 19850
      biological role 19848
        inhibitor 18941
          PF-4708671 4
Path 2
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  CHEBI ontology 19879
    subatomic particle 19877
      composite particle 19877
        hadron 19877
          baryon 19877
            nucleon 19877
              atomic nucleus 19877
                atom 19877
                  main group element atom 19816
                    p-block element atom 19816
                      p-block molecular entity 19816
                        carbon group molecular entity 19756
                          organic molecular entity 19753
                            PF-4708671 4
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