CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: PF-4708671
Accession: CHEBI:232526
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Synonyms: related_synonym: 2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole; Formula=C19H21F3N6; InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26); InChIKey=FBLPQCAQRNSVHB-UHFFFAOYSA-N; SMILES=CCC1=CN=CN=C1N2CCN(CC2)CC3=NC=4C=CC(=CC4N3)C(F)(F)F
xref: CAS:1255517-76-0
xref_mesh: MESH:C552719
xref: PMID:20704563
G
Bbc3
Bcl-2 binding component 3
multiple interactions
ISO
[NVP-BSK805 co-treated with PF-4708671] results in increased expression of BBC3 protein
CTD
PMID:26242912
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509
G
Bcl2l11
Bcl2-like 11
multiple interactions
ISO
[NVP-BSK805 co-treated with PF-4708671] results in increased expression of BCL2L11 protein modified form
CTD
PMID:26242912
NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068
G
Casp3
caspase 3
multiple interactions
EXP
PF-4708671 promotes the reaction [Isoflurane results in increased cleavage of CASP3 protein]
CTD
PMID:25597859
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Dlg4
discs large MAGUK scaffold protein 4
multiple interactions
EXP
PF-4708671 promotes the reaction [Isoflurane results in decreased expression of DLG4 protein]
CTD
PMID:25597859
NCBI chr10:55,239,397...55,267,780
Ensembl chr10:54,739,470...54,767,153
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