|
G |
Marchf6 |
membrane associated ring-CH-type finger 6 |
increases stability |
ISO |
CB-5083 results in increased stability of MARCHF6 protein |
CTD |
PMID:30545937 |
|
NCBI chr 2:82,455,686...82,532,917
|
|
G |
Pml |
PML nuclear body scaffold |
multiple interactions |
ISO |
CB-5083 inhibits the reaction [Arsenic results in increased degradation of PML protein]; CB-5083 inhibits the reaction [RNF4 protein promotes the reaction [Arsenic results in increased degradation of PML protein]]; CB-5083 promotes the reaction [Arsenic promotes the reaction [SUMO1 protein binds to PML protein]]; CB-5083 promotes the reaction [Arsenic promotes the reaction [SUMO2 protein binds to PML protein]]; CB-5083 promotes the reaction [Arsenic results in increased ubiquitination of PML protein]; SENP1 protein inhibits the reaction [CB-5083 promotes the reaction [Arsenic promotes the reaction [SUMO1 protein binds to PML protein]]]; SENP1 protein inhibits the reaction [CB-5083 promotes the reaction [Arsenic promotes the reaction [SUMO2 protein binds to PML protein]]]; SENP1 protein inhibits the reaction [CB-5083 promotes the reaction [Arsenic results in increased ubiquitination of PML protein]]; USP2 protein inhibits the reaction [CB-5083 promotes the reaction [Arsenic results in increased ubiquitination of PML protein]] |
CTD |
PMID:36880596 |
|
NCBI chr 8:58,627,347...58,661,927
|
|
G |
Rnf4 |
ring finger protein 4 |
multiple interactions |
ISO |
CB-5083 inhibits the reaction [RNF4 protein promotes the reaction [Arsenic results in increased degradation of PML protein]] |
CTD |
PMID:36880596 |
|
NCBI chr14:76,401,292...76,423,270
|
|
G |
Senp1 |
SUMO specific peptidase 1 |
multiple interactions |
ISO |
SENP1 protein inhibits the reaction [CB-5083 promotes the reaction [Arsenic promotes the reaction [SUMO1 protein binds to PML protein]]]; SENP1 protein inhibits the reaction [CB-5083 promotes the reaction [Arsenic promotes the reaction [SUMO2 protein binds to PML protein]]]; SENP1 protein inhibits the reaction [CB-5083 promotes the reaction [Arsenic results in increased ubiquitination of PML protein]] |
CTD |
PMID:36880596 |
|
NCBI chr 7:131,042,237...131,105,826
|
|
G |
Sumo1 |
small ubiquitin-like modifier 1 |
multiple interactions |
ISO |
CB-5083 promotes the reaction [Arsenic promotes the reaction [SUMO1 protein binds to PML protein]]; SENP1 protein inhibits the reaction [CB-5083 promotes the reaction [Arsenic promotes the reaction [SUMO1 protein binds to PML protein]]] |
CTD |
PMID:36880596 |
|
NCBI chr 9:61,078,790...61,108,697
|
|
G |
Sumo2 |
small ubiquitin-like modifier 2 |
multiple interactions |
ISO |
CB-5083 promotes the reaction [Arsenic promotes the reaction [SUMO2 protein binds to PML protein]]; SENP1 protein inhibits the reaction [CB-5083 promotes the reaction [Arsenic promotes the reaction [SUMO2 protein binds to PML protein]]] |
CTD |
PMID:36880596 |
|
NCBI chr10:100,771,941...100,784,503
|
|
G |
Usp2 |
ubiquitin specific peptidase 2 |
multiple interactions |
ISO |
USP2 protein inhibits the reaction [CB-5083 promotes the reaction [Arsenic results in increased ubiquitination of PML protein]] |
CTD |
PMID:36880596 |
|
NCBI chr 8:53,308,264...53,336,800
|
|
G |
Vcp |
valosin-containing protein |
decreases activity |
ISO |
CB-5083 results in decreased activity of VCP protein |
CTD |
PMID:30545937 |
|
NCBI chr 5:62,005,984...62,025,387
|
|