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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:GSK2193874
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Accession:CHEBI:232516 term browser browse the term
Synonyms:exact_synonym: 7-bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide
 related_synonym: Formula=C37H38BrF3N4O;   InChI=1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36)26-9-3-1-4-10-26/h1,3-4,7-13,22-23,29H,2,5-6,14-21,24H2,(H,43,46);   InChIKey=UIVOZBSCHXCGPS-UHFFFAOYSA-N;   SMILES=C1=CC=C(C=C1)C2(CC2)\\N=C(\\C=3C=4C=CC(=CC4N=C(C=5C=CC=C(C5)C(F)(F)F)C3CN6CCC(CC6)N7CCCCC7)Br)/O
 xref_mesh: MESH:C000628859
 xref: PMID:28523109



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GSK2193874 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 multiple interactions ISO GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein] CTD PMID:30517707 NCBI chr19:51,402,178...51,471,572 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein] CTD PMID:30517707 NCBI chr 8:129,517,576...129,544,661 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein] CTD PMID:30517707 NCBI chr11:76,004,502...76,154,665 JBrowse link
G Il13 interleukin 13 multiple interactions ISO GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein] CTD PMID:30517707 NCBI chr10:38,290,926...38,293,483 JBrowse link
G Il18 interleukin 18 multiple interactions ISO GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein] CTD PMID:30517707 NCBI chr 8:59,802,072...59,829,275 JBrowse link
G Il4 interleukin 4 multiple interactions ISO GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein] CTD PMID:30517707 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Il5 interleukin 5 multiple interactions ISO GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein] CTD PMID:30517707 NCBI chr10:38,375,132...38,378,003 JBrowse link
G Il6 interleukin 6 multiple interactions ISO GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein] CTD PMID:30517707 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions ISO GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TRPV4 protein] CTD PMID:30517707 NCBI chr12:47,599,161...47,638,143 JBrowse link

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Path 1
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  CHEBI ontology 19898
    role 19869
      biological role 19867
        pharmacological role 19102
          antagonist 17260
            GSK2193874 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      p-block molecular entity 19835
                        carbon group molecular entity 19774
                          organic molecular entity 19770
                            GSK2193874 9
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