CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: GSK2193874
Accession: CHEBI:232516
browse the term
Synonyms: exact_synonym: 7-bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide
related_synonym: Formula=C37H38BrF3N4O; InChI=1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36)26-9-3-1-4-10-26/h1,3-4,7-13,22-23,29H,2,5-6,14-21,24H2,(H,43,46); InChIKey=UIVOZBSCHXCGPS-UHFFFAOYSA-N; SMILES=C1=CC=C(C=C1)C2(CC2)\\N=C(\\C=3C=4C=CC(=CC4N=C(C=5C=CC=C(C5)C(F)(F)F)C3CN6CCC(CC6)N7CCCCC7)Br)/O
xref_mesh: MESH:C000628859
xref: PMID:28523109
G
Cdh1
cadherin 1
multiple interactions
ISO
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]
CTD
PMID:30517707
NCBI chr19:51,402,178...51,471,572
G
Ctnnb1
catenin beta 1
multiple interactions
ISO
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of and results in increased activity of and affects the localization of CTNNB1 protein]
CTD
PMID:30517707
NCBI chr 8:129,517,576...129,544,661
G
Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
ISO
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]
CTD
PMID:30517707
NCBI chr11:76,004,502...76,154,665
G
Il13
interleukin 13
multiple interactions
ISO
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]
CTD
PMID:30517707
NCBI chr10:38,290,926...38,293,483
G
Il18
interleukin 18
multiple interactions
ISO
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein]
CTD
PMID:30517707
NCBI chr 8:59,802,072...59,829,275
G
Il4
interleukin 4
multiple interactions
ISO
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]
CTD
PMID:30517707
NCBI chr10:38,272,003...38,277,549
G
Il5
interleukin 5
multiple interactions
ISO
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]
CTD
PMID:30517707
NCBI chr10:38,375,132...38,378,003
G
Il6
interleukin 6
multiple interactions
ISO
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]
CTD
PMID:30517707
NCBI chr 4:5,889,999...5,894,575
G
Trpv4
transient receptor potential cation channel, subfamily V, member 4
multiple interactions
ISO
GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of TRPV4 protein]
CTD
PMID:30517707
NCBI chr12:47,599,161...47,638,143
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all