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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cinnamaldehydes
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Accession:CHEBI:23245 term browser browse the term
Definition:An enal based on a cinnamaldehyde skeleton and its substituted derivatives.



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3-phenylprop-2-enal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO cinnamaldehyde results in increased expression of ABCC3 mRNA CTD PMID:19524605 NCBI chr10:79,793,571...79,839,528 JBrowse link
G Abhd12b abhydrolase domain containing 12B increases expression ISO cinnamaldehyde results in increased expression of ABHD12B mRNA CTD PMID:19524605 NCBI chr 6:88,668,627...88,696,435 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP cinnamaldehyde inhibits the reaction [Glucose results in increased expression of ACTA2 protein] CTD PMID:20060012 NCBI chr 1:241,159,723...241,172,503 JBrowse link
G Actb actin, beta increases metabolic processing ISO cinnamaldehyde results in increased metabolism of ACTB protein CTD PMID:29267982 NCBI chr12:16,776,664...16,779,634 JBrowse link
G Adam23 ADAM metallopeptidase domain 23 increases expression ISO cinnamaldehyde results in increased expression of ADAM23 mRNA CTD PMID:19524605 NCBI chr 9:64,862,649...65,009,718 JBrowse link
G Adk adenosine kinase increases expression ISO cinnamaldehyde results in increased expression of ADK mRNA CTD PMID:19524605 NCBI chr15:2,912,543...3,295,745 JBrowse link
G Adm adrenomedullin increases expression ISO cinnamaldehyde results in increased expression of ADM mRNA CTD PMID:19524605 NCBI chr 1:174,164,178...174,182,372 JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein] CTD PMID:33522063 NCBI chr20:4,152,758...4,155,956 JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO cinnamaldehyde results in increased expression of AKR1B10 mRNA CTD PMID:30806763 NCBI chr 4:64,005,632...64,027,860 JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO cinnamaldehyde results in increased expression of AKR1C1 mRNA CTD PMID:19524605 NCBI chr17:70,720,397...70,747,285 JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity
multiple interactions
increases expression
ISO cinnamaldehyde results in increased activity of AKR1C2 promoter
NFE2L2 mRNA promotes the reaction [cinnamaldehyde results in increased expression of AKR1C2 mRNA]
CTD PMID:21195160 PMID:25724174 PMID:26244607 NCBI chr17:70,669,684...70,717,935 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
cinnamaldehyde results in increased phosphorylation of AKT1 protein
CTD PMID:20467561 PMID:21469739 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Alb albumin increases metabolic processing ISO cinnamaldehyde results in increased metabolism of ALB protein CTD PMID:29267982 NCBI chr14:17,891,564...17,907,043 JBrowse link
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 increases expression ISO cinnamaldehyde results in increased expression of ALS2 mRNA CTD PMID:19524605 NCBI chr 9:68,107,310...68,180,192 JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO cinnamaldehyde results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 1:164,884,823...164,929,899 JBrowse link
G Arhgap23 Rho GTPase activating protein 23 increases expression ISO cinnamaldehyde results in increased expression of ARHGAP23 mRNA CTD PMID:19524605 NCBI chr10:82,891,021...82,993,230 JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO cinnamaldehyde results in increased expression of ATF3 mRNA CTD PMID:23999411 PMID:27965148 NCBI chr13:105,274,103...105,331,653 JBrowse link
G Atp11a ATPase phospholipid transporting 11A increases expression ISO cinnamaldehyde results in increased expression of ATP11A mRNA CTD PMID:19524605 NCBI chr16:76,657,752...76,767,640 JBrowse link
G B2m beta-2 microglobulin decreases expression ISO cinnamaldehyde results in decreased expression of B2M mRNA CTD PMID:28219650 NCBI chr 3:129,549,236...129,555,354 JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO BACH1 mRNA promotes the reaction [cinnamaldehyde results in increased expression of HMOX1 mRNA] CTD PMID:26244607 NCBI chr11:40,425,721...40,461,118 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
cinnamaldehyde results in increased expression of BAX protein
cinnamaldehyde inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]
Vitamin E inhibits the reaction [cinnamaldehyde results in increased expression of BAX protein]
CTD PMID:15566391 PMID:15964311 PMID:32628957 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bcap29 B-cell receptor-associated protein 29 increases expression ISO cinnamaldehyde results in increased expression of BCAP29 mRNA CTD PMID:19524605 NCBI chr 6:48,182,702...48,222,698 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
Vitamin E inhibits the reaction [cinnamaldehyde results in decreased expression of BCL2 protein]
cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]
cinnamaldehyde analog results in decreased expression of BCL2 protein; cinnamaldehyde results in decreased expression of BCL2 protein
CTD PMID:15566391 PMID:15964311 PMID:17510524 PMID:32628957 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO cinnamaldehyde results in increased cleavage of BID protein CTD PMID:15964311 NCBI chr 4:155,785,366...155,808,775 JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions
ISO cinnamaldehyde results in decreased expression of BIRC2 protein
Vitamin E inhibits the reaction [cinnamaldehyde results in decreased expression of BIRC2 protein]
CTD PMID:15566391 NCBI chr 8:13,253,697...13,273,672 JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
decreases expression
ISO Vitamin E inhibits the reaction [cinnamaldehyde results in decreased expression of BIRC3 protein] CTD PMID:15566391 NCBI chr 8:13,285,702...13,313,329 JBrowse link
G Casp1 caspase 1 increases expression ISO cinnamaldehyde results in increased expression of CASP1 mRNA CTD PMID:19000754 NCBI chr 8:10,746,338...10,882,295 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
increases expression
ISO Vitamin E inhibits the reaction [cinnamaldehyde results in increased activity of CASP3 protein]
cinnamaldehyde analog results in increased activity of CASP3 protein; cinnamaldehyde results in increased activity of CASP3 protein
cinnamaldehyde results in increased cleavage of CASP3 protein
cinnamaldehyde analog results in increased expression of CASP3 protein
CTD PMID:15566391 PMID:16343908 PMID:17510524 PMID:19000754 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp8 caspase 8 increases activity ISO cinnamaldehyde results in increased activity of CASP8 protein CTD PMID:15964311 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Casp9 caspase 9 decreases expression ISO cinnamaldehyde results in decreased expression of CASP9 mRNA CTD PMID:28219650
G Cat catalase multiple interactions
decreases activity
increases expression
ISO
EXP
NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of CAT mRNA]
cinnamaldehyde results in decreased activity of CAT protein
cinnamaldehyde inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD PMID:17076691 PMID:23959918 PMID:28219650 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Ccdc34 coiled-coil domain containing 34 increases expression ISO cinnamaldehyde results in increased expression of CCDC34 mRNA CTD PMID:19524605 NCBI chr 3:96,553,074...96,588,310 JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression
affects expression
ISO cinnamaldehyde results in increased expression of CCL20 mRNA
cinnamaldehyde affects the expression of CCL20 mRNA
CTD PMID:28219650 PMID:30806763 NCBI chr 9:91,837,139...91,839,736 JBrowse link
G Ccl22 C-C motif chemokine ligand 22 decreases expression ISO cinnamaldehyde results in decreased expression of CCL22 mRNA CTD PMID:28219650 NCBI chr19:10,263,589...10,270,359 JBrowse link
G Ccl3 C-C motif chemokine ligand 3 affects expression
increases secretion
multiple interactions
ISO cinnamaldehyde affects the expression of CCL3 mRNA
cinnamaldehyde results in increased secretion of CCL3 protein
NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CCL3 mRNA]
CTD PMID:23624239 PMID:28219650 NCBI chr10:68,948,889...68,950,439 JBrowse link
G Ccl4 C-C motif chemokine ligand 4 affects expression
increases secretion
ISO cinnamaldehyde affects the expression of CCL4 mRNA
cinnamaldehyde results in increased secretion of CCL4 protein
CTD PMID:28219650 PMID:30806763 NCBI chr10:68,963,893...68,965,728 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion
decreases expression
ISO cinnamaldehyde results in increased secretion of CCL5 protein
cinnamaldehyde results in decreased expression of CCL5 mRNA
CTD PMID:20488241 PMID:28219650 NCBI chr10:68,820,330...68,824,906 JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO cinnamaldehyde results in decreased expression of CCN2 mRNA CTD PMID:17178418 NCBI chr 1:22,621,498...22,624,614 JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of CCND1 protein] CTD PMID:32628957 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Cd274 CD274 molecule increases expression ISO cinnamaldehyde results in increased expression of CD274 protein CTD PMID:20488241 PMID:23624239 NCBI chr 1:236,526,215...236,549,956 JBrowse link
G Cd80 Cd80 molecule increases expression ISO cinnamaldehyde results in increased expression of CD80 mRNA CTD PMID:28219650 NCBI chr11:75,760,073...75,798,978 JBrowse link
G Cd83 CD83 molecule decreases expression
increases expression
ISO cinnamaldehyde results in decreased expression of CD83 mRNA
cinnamaldehyde results in increased expression of CD83 mRNA
CTD PMID:27196738 PMID:28219650 NCBI chr17:21,093,281...21,113,223 JBrowse link
G Cd86 CD86 molecule decreases expression
increases expression
ISO cinnamaldehyde results in decreased expression of CD86 mRNA
cinnamaldehyde results in increased expression of CD86 protein
cinnamaldehyde results in increased expression of CD86 mRNA; cinnamaldehyde results in increased expression of CD86 protein
CTD PMID:11244134 PMID:19524605 PMID:19665512 PMID:20488241 PMID:23624239 More... NCBI chr11:77,647,565...77,706,178 JBrowse link
G Cdc25b cell division cycle 25B decreases activity ISO cinnamaldehyde analog results in decreased activity of CDC25B protein CTD PMID:16343908 NCBI chr 3:138,860,148...138,870,287 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO cinnamaldehyde results in increased expression of CDKN1A mRNA; cinnamaldehyde results in increased expression of CDKN1A protein CTD PMID:19000754 NCBI chr20:7,150,820...7,161,373 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO cinnamaldehyde results in decreased expression of CEBPA mRNA CTD PMID:21401097 NCBI chr 1:87,759,631...87,762,303 JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO cinnamaldehyde results in increased expression of CES1 mRNA CTD PMID:19524605 NCBI chr19:30,046,494...30,085,039 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases phosphorylation EXP cinnamaldehyde results in decreased phosphorylation of CHUK protein CTD PMID:17486422 NCBI chr 1:252,908,748...252,944,273 JBrowse link
G Clec4a3 C-type lectin domain family 4, member A3 decreases expression ISO cinnamaldehyde results in decreased expression of CLEC4A protein CTD PMID:23624239 NCBI chr 4:156,214,030...156,224,818 JBrowse link
G Clk2 CDC-like kinase 2 decreases expression ISO cinnamaldehyde results in decreased expression of CLK2 mRNA CTD PMID:17178418 NCBI chr 2:176,868,423...176,880,412 JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 decreases expression ISO cinnamaldehyde results in decreased expression of CNOT2 mRNA CTD PMID:19524605 NCBI chr 7:52,130,445...52,222,338 JBrowse link
G Col7a1 collagen type VII alpha 1 chain increases expression ISO cinnamaldehyde results in increased expression of COL7A1 mRNA CTD PMID:19524605 NCBI chr 8:109,604,877...109,637,249 JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO cinnamaldehyde results in decreased expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 9:73,397,333...73,466,339 JBrowse link
G Crem cAMP responsive element modulator increases expression ISO cinnamaldehyde results in increased expression of CREM mRNA CTD PMID:19524605 NCBI chr17:58,932,011...59,001,160 JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 increases expression ISO cinnamaldehyde results in increased expression of CRIM1 mRNA CTD PMID:19524605 NCBI chr 6:16,695,864...16,870,264 JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein decreases phosphorylation ISO cinnamaldehyde results in decreased phosphorylation of CRKL protein CTD PMID:21729535 NCBI chr11:97,033,033...97,067,457 JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO cinnamaldehyde results in increased expression of CXCL1 mRNA CTD PMID:30806763 NCBI chr14:17,477,542...17,479,321 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions
ISO cinnamaldehyde results in increased expression of CXCL10 mRNA
NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CXCL10 mRNA]
CTD PMID:28219650 NCBI chr14:15,989,066...15,991,263 JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO cinnamaldehyde results in increased expression of CXCL14 mRNA CTD PMID:30806763 NCBI chr17:8,323,150...8,331,176 JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
affects expression
ISO cinnamaldehyde results in increased expression of CXCL1 mRNA
NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CXCL1 mRNA]
cinnamaldehyde affects the expression of CXCL1 mRNA
CTD PMID:28219650 PMID:30806763 NCBI chr14:17,571,900...17,573,624 JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO cinnamaldehyde results in increased expression of CXCR1 mRNA CTD PMID:30806763 NCBI chr 9:83,216,040...83,220,225 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO cinnamaldehyde results in decreased expression of CXCR4 mRNA CTD PMID:28219650 NCBI chr13:42,630,383...42,634,288 JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
ISO Vitamin E inhibits the reaction [cinnamaldehyde affects the localization of CYCS protein] CTD PMID:15566391 NCBI chr 4:80,982,667...80,984,767 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO cinnamaldehyde results in increased expression of CYP1A1 mRNA CTD PMID:30806763 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO cinnamaldehyde results in increased expression of CYP7A1 mRNA CTD PMID:19000754 NCBI chr 5:24,174,505...24,184,202 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO cinnamaldehyde results in increased expression of DDIT3 mRNA CTD PMID:19000754 NCBI chr 7:65,001,695...65,006,517 JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression ISO cinnamaldehyde results in decreased expression of DDIT4 mRNA CTD PMID:17178418 NCBI chr20:28,434,938...28,437,037 JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization
multiple interactions
ISO cinnamaldehyde affects the localization of DIABLO protein
Vitamin E inhibits the reaction [cinnamaldehyde affects the localization of DIABLO protein]
CTD PMID:15566391 NCBI chr12:38,716,668...38,731,285 JBrowse link
G Dmtn dematin actin binding protein increases expression ISO cinnamaldehyde results in increased expression of DMTN mRNA CTD PMID:19524605 NCBI chr15:45,677,974...45,702,261 JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO cinnamaldehyde results in increased expression of DNAJB4 mRNA CTD PMID:23999411 PMID:27965148 NCBI chr 2:243,790,296...243,819,042 JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO cinnamaldehyde results in decreased expression of DNMT3B mRNA CTD PMID:17178418 NCBI chr 3:142,130,588...142,169,128 JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO cinnamaldehyde results in increased expression of DUSP1 mRNA CTD PMID:30806763 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO cinnamaldehyde results in decreased expression of DUSP6 mRNA CTD PMID:17178418 NCBI chr 7:35,979,502...35,983,834 JBrowse link
G Dynlrb1 dynein light chain roadblock-type 1 increases expression ISO cinnamaldehyde results in increased expression of DYNLRB1 mRNA CTD PMID:19524605 NCBI chr 3:143,742,427...143,764,227 JBrowse link
G Eaf2 ELL associated factor 2 decreases expression ISO cinnamaldehyde results in decreased expression of EAF2 mRNA CTD PMID:19524605 NCBI chr11:63,960,200...64,004,610 JBrowse link
G Egr1 early growth response 1 increases expression ISO cinnamaldehyde results in increased expression of EGR1 mRNA CTD PMID:19000754 NCBI chr18:26,737,078...26,740,877 JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A increases metabolic processing ISO cinnamaldehyde results in increased metabolism of EIF3A protein CTD PMID:29267982 NCBI chr 1:269,888,730...269,925,785 JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression ISO cinnamaldehyde results in increased expression of EPAS1 mRNA CTD PMID:19524605 NCBI chr 6:13,543,252...13,626,147 JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein] CTD PMID:17571167 NCBI chr 2:28,507,003...28,519,954 JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO cinnamaldehyde results in increased expression of FABP4 mRNA CTD PMID:30806763 NCBI chr 2:93,488,251...93,492,961 JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
ISO dorsomorphin inhibits the reaction [cinnamaldehyde results in decreased expression of FAS mRNA] CTD PMID:21401097 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Fcgr2b Fc gamma receptor 2B increases expression ISO cinnamaldehyde results in increased expression of FCGR2B mRNA CTD PMID:19524605 NCBI chr13:85,725,897...85,740,517 JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO cinnamaldehyde results in decreased expression of FGFR2 mRNA CTD PMID:17178418 NCBI chr 1:194,175,703...194,280,914 JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 increases expression ISO cinnamaldehyde results in increased expression of FMO5 mRNA CTD PMID:19000754 NCBI chr 2:185,197,184...185,249,699 JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP cinnamaldehyde inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:20060012 NCBI chr 9:80,645,507...80,714,200 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO cinnamaldehyde analog results in decreased expression of FOS protein CTD PMID:17510524 NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO cinnamaldehyde results in increased expression of FTH1 mRNA CTD PMID:19524605 PMID:24211530 NCBI chr 1:216,052,037...216,054,325 JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO cinnamaldehyde results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 1:105,072,858...105,074,705 JBrowse link
G Fzd2 frizzled class receptor 2 increases expression ISO cinnamaldehyde results in increased expression of FZD2 mRNA CTD PMID:17178418 NCBI chr10:88,061,988...88,063,898 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO cinnamaldehyde results in increased expression of G6PD mRNA CTD PMID:19524605 NCBI chr  X:157,352,364...157,372,144 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO cinnamaldehyde results in increased expression of GCLC mRNA; cinnamaldehyde results in increased expression of GCLC protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; NFE2L2 mRNA affects the reaction [cinnamaldehyde results in increased expression of GCLC protein]; pyrazolanthrone inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein]
CTD PMID:17178418 PMID:20351055 PMID:21469739 PMID:30806763 NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
ISO cinnamaldehyde results in increased expression of GCLM mRNA
[cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA
CTD PMID:17178418 PMID:20351055 PMID:23999411 PMID:24211530 PMID:27965148 More... NCBI chr 2:213,032,135...213,052,192 JBrowse link
G Glrx glutaredoxin increases expression
increases activity
multiple interactions
ISO cinnamaldehyde results in increased expression of GLRX mRNA
cinnamaldehyde results in increased activity of GLRX protein
[Cadmium Chloride affects the activity of GLRX protein] inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; [cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamaldehyde results in increased activity of GLRX protein] which results in increased glutathionylation of RELA protein
CTD PMID:20351055 NCBI chr 2:5,341,873...5,351,686 JBrowse link
G Gpr21 G protein-coupled receptor 21 increases expression ISO cinnamaldehyde results in increased expression of GPR21 mRNA CTD PMID:19524605 NCBI chr 3:21,275,289...21,279,008 JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
affects expression
ISO NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX1 mRNA]
cinnamaldehyde affects the expression of GPX1 mRNA
CTD PMID:28219650 NCBI chr 8:117,905,462...117,906,588 JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions
increases expression
affects expression
ISO NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX2 mRNA]
cinnamaldehyde affects the expression of GPX2 mRNA
CTD PMID:19000754 PMID:28219650 NCBI chr 6:101,226,745...101,230,033 JBrowse link
G Gpx5 glutathione peroxidase 5 affects expression
multiple interactions
ISO cinnamaldehyde affects the expression of GPX5 mRNA
NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX5 mRNA]
CTD PMID:28219650 NCBI chr17:43,436,126...43,443,074 JBrowse link
G Gpx6 glutathione peroxidase 6 affects expression
multiple interactions
ISO cinnamaldehyde affects the expression of GPX6 mRNA
NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX6 mRNA]
CTD PMID:28219650 NCBI chr17:43,408,472...43,416,091 JBrowse link
G Gpx7 glutathione peroxidase 7 decreases expression ISO cinnamaldehyde results in decreased expression of GPX7 mRNA CTD PMID:28219650 NCBI chr 5:123,145,151...123,153,141 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO cinnamaldehyde results in decreased expression of GSK3B mRNA CTD PMID:28219650 NCBI chr11:76,004,502...76,154,665 JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
ISO cinnamaldehyde results in increased expression of GSR mRNA
NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GSR mRNA]
CTD PMID:19000754 PMID:28219650 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO cinnamaldehyde results in increased expression of GSTM1 mRNA CTD PMID:28219650 NCBI chr 2:198,338,005...198,346,007 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO cinnamaldehyde binds to and results in decreased activity of GSTP1 protein CTD PMID:9463521 NCBI chr 1:210,767,237...210,770,242 JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects expression ISO cinnamaldehyde affects the expression of GSTT1 mRNA CTD PMID:28219650 NCBI chr20:12,856,068...12,873,020 JBrowse link
G Hbb hemoglobin subunit beta increases metabolic processing ISO cinnamaldehyde results in increased metabolism of HBB protein CTD PMID:29267982 NCBI chr 1:167,662,310...167,663,721 JBrowse link
G Hfe homeostatic iron regulator increases expression ISO cinnamaldehyde results in increased expression of HFE mRNA CTD PMID:19524605 NCBI chr17:41,841,302...41,849,359 JBrowse link
G Hist1h4m histone cluster 1, H4m increases metabolic processing ISO cinnamaldehyde results in increased metabolism of H4C1 protein CTD PMID:29267982 NCBI chr17:47,393,764...47,394,168 JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO cinnamaldehyde results in decreased expression of HMGB1 mRNA CTD PMID:28219650 NCBI chr12:11,009,236...11,015,941 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO cinnamaldehyde results in increased expression of HMOX1 mRNA
cinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of HMOX1 protein]; [ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of HMOX1 mRNA; [ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of HMOX1 protein; BACH1 mRNA promotes the reaction [cinnamaldehyde results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA promotes the reaction [cinnamaldehyde results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [cinnamaldehyde results in increased expression of HMOX1 protein]
cinnamaldehyde analog results in increased expression of HMOX1 mRNA; cinnamaldehyde analog results in increased expression of HMOX1 protein; cinnamaldehyde results in increased expression of HMOX1 mRNA; cinnamaldehyde results in increased expression of HMOX1 protein
CTD PMID:17178418 PMID:18304597 PMID:18482591 PMID:19000754 PMID:19033392 More... NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases metabolic processing ISO cinnamaldehyde results in increased metabolism of HNRNPK protein CTD PMID:29267982 NCBI chr17:6,269,302...6,280,429 JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 decreases mutagenesis ISO cinnamaldehyde results in decreased mutagenesis of HPRT1 gene CTD PMID:17178418 NCBI chr  X:132,736,175...132,768,149 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases metabolic processing ISO cinnamaldehyde results in increased metabolism of HSP90AA1 protein CTD PMID:29267982 NCBI chr 6:135,523,604...135,529,687 JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO cinnamaldehyde results in increased expression of HSPA1B mRNA CTD PMID:17178418 NCBI chr20:3,859,756...3,863,800 JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO cinnamaldehyde results in increased expression of HSPA6 mRNA CTD PMID:23999411 NCBI chr13:85,805,911...85,807,052 JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases metabolic processing ISO cinnamaldehyde results in increased metabolism of HSPA8 protein CTD PMID:29267982 NCBI chr 8:50,080,514...50,084,376 JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO cinnamaldehyde results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr12:5,390,916...5,410,224 JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression ISO cinnamaldehyde results in increased expression of HTATIP2 mRNA CTD PMID:19524605 NCBI chr 1:108,609,424...108,624,810 JBrowse link
G Htra2 HtrA serine peptidase 2 affects localization
multiple interactions
ISO cinnamaldehyde affects the localization of HTRA2 protein
Vitamin E inhibits the reaction [cinnamaldehyde affects the localization of HTRA2 protein]
CTD PMID:15566391 NCBI chr 4:117,114,631...117,117,793 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO
EXP
[cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]
cinnamaldehyde results in increased expression of ICAM1 mRNA; cinnamaldehyde results in increased expression of ICAM1 protein
CTD PMID:20351055 PMID:30806763 PMID:33522063 NCBI chr 8:27,829,688...27,841,618 JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO cinnamaldehyde results in decreased expression of IFI27 mRNA CTD PMID:19524605 NCBI chr 6:122,590,461...122,596,996 JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO cinnamaldehyde results in decreased expression of IFI44L mRNA CTD PMID:19524605 NCBI chr 2:243,328,629...243,366,404 JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:17920563 NCBI chr 5:108,066,650...108,067,487 JBrowse link
G Ifng interferon gamma increases expression
affects expression
ISO cinnamaldehyde results in increased expression of IFNG protein
cinnamaldehyde affects the expression of IFNG mRNA
CTD PMID:11244134 PMID:28219650 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases phosphorylation EXP cinnamaldehyde results in decreased phosphorylation of IKBKB protein CTD PMID:17486422 NCBI chr16:76,021,968...76,075,717 JBrowse link
G Il10 interleukin 10 affects expression ISO cinnamaldehyde affects the expression of IL10 mRNA CTD PMID:28219650 NCBI chr13:45,024,921...45,029,586 JBrowse link
G Il12a interleukin 12A multiple interactions
affects expression
ISO NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of IL12A mRNA]
cinnamaldehyde affects the expression of IL12A mRNA
CTD PMID:28219650 NCBI chr 2:155,275,734...155,282,997 JBrowse link
G Il12b interleukin 12B decreases expression ISO cinnamaldehyde results in decreased expression of IL12B mRNA CTD PMID:28219650 NCBI chr10:29,390,300...29,405,194 JBrowse link
G Il16 interleukin 16 increases secretion
multiple interactions
ISO cinnamaldehyde results in increased secretion of IL16 protein
cinnamaldehyde results in increased expression of and results in increased secretion of IL16 protein
CTD PMID:23624239 PMID:30806763 NCBI chr 1:137,617,702...137,718,022 JBrowse link
G Il18 interleukin 18 increases expression ISO cinnamaldehyde results in increased expression of IL18 mRNA; cinnamaldehyde results in increased expression of IL18 protein CTD PMID:23063874 PMID:30806763 NCBI chr 8:59,802,072...59,829,275 JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions
ISO cinnamaldehyde results in increased expression of IL1A mRNA
[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL1A mRNA; [NFE2L2 protein affects the susceptibility to cinnamaldehyde] which affects the expression of IL1A mRNA; NFE2L2 protein affects the reaction [[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL1A mRNA]
CTD PMID:25290854 PMID:28219650 PMID:30806763 PMID:33715048 PMID:37089166 NCBI chr 3:136,979,804...136,990,236 JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL1B mRNA; [NFE2L2 protein affects the susceptibility to cinnamaldehyde] which affects the expression of IL1B mRNA; cinnamaldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL1B protein]; NFE2L2 protein affects the reaction [[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL1B mRNA]
cinnamaldehyde inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; cinnamaldehyde inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of IL1B protein]
cinnamaldehyde results in increased expression of IL1B mRNA
cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of IL1B mRNA]
CTD PMID:16624280 PMID:19524605 PMID:20467561 PMID:21807015 PMID:28219650 More... NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [NFE2L2 protein affects the susceptibility to cinnamaldehyde] which affects the expression of IL23A mRNA; NFE2L2 protein affects the reaction [[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL23A mRNA] CTD PMID:37089166 NCBI chr 7:1,306,320...1,308,434 JBrowse link
G Il24 interleukin 24 multiple interactions ISO [NFE2L2 protein affects the susceptibility to cinnamaldehyde] which affects the expression of IL24 mRNA; cinnamaldehyde affects the reaction [ethylhexadecyldimethylammonium results in increased expression of IL24 mRNA]; NFE2L2 protein affects the reaction [[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL24 mRNA] CTD PMID:37089166 NCBI chr13:44,905,362...44,910,760 JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL6 mRNA; [NFE2L2 protein affects the susceptibility to cinnamaldehyde] which affects the expression of IL6 mRNA; cinnamaldehyde affects the reaction [ethylhexadecyldimethylammonium results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL6 mRNA]
cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of IL6 protein]; cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
CTD PMID:17868967 PMID:32628957 PMID:33522063 PMID:37089166 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Il7r interleukin 7 receptor increases expression ISO cinnamaldehyde results in increased expression of IL7R mRNA CTD PMID:20713136 NCBI chr 2:58,452,393...58,477,757 JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO cinnamaldehyde results in decreased expression of INSIG1 mRNA CTD PMID:17178418 NCBI chr 4:8,049,339...8,057,812 JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein] CTD PMID:17920563 NCBI chr 1:104,616,608...104,621,402 JBrowse link
G Itga11 integrin subunit alpha 11 increases expression ISO cinnamaldehyde results in increased expression of ITGA11 mRNA CTD PMID:19524605 NCBI chr 8:63,145,998...63,254,714 JBrowse link
G Jak1 Janus kinase 1 multiple interactions EXP cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of JAK1 protein] CTD PMID:32628957 NCBI chr 5:120,895,606...121,004,207 JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of JAK2 protein] CTD PMID:33522063 NCBI chr 1:236,408,905...236,468,769 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO cinnamaldehyde analog results in decreased expression of JUN protein CTD PMID:17510524 NCBI chr 5:115,009,900...115,012,993 JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression ISO cinnamaldehyde results in decreased expression of JUND mRNA CTD PMID:17178418 NCBI chr16:18,734,121...18,735,799 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects expression
increases expression
ISO cinnamaldehyde affects the expression of KEAP1 mRNA
cinnamaldehyde results in increased expression of KEAP1 protein
CTD PMID:19033392 PMID:28219650 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Lhfpl6 LHFPL tetraspan subfamily member 6 increases expression ISO cinnamaldehyde results in increased expression of LHFPL6 mRNA CTD PMID:19524605 NCBI chr 2:139,276,810...139,474,740 JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 decreases expression ISO cinnamaldehyde results in decreased expression of LMCD1 mRNA CTD PMID:19524605 NCBI chr 4:145,393,153...145,452,049 JBrowse link
G Lmna lamin A/C increases metabolic processing ISO cinnamaldehyde results in increased metabolism of LMNA protein CTD PMID:29267982 NCBI chr 2:176,237,564...176,265,301 JBrowse link
G Lpl lipoprotein lipase decreases expression ISO cinnamaldehyde results in decreased expression of LPL mRNA CTD PMID:21401097 NCBI chr16:25,596,205...25,621,928 JBrowse link
G Lrp12 LDL receptor related protein 12 increases expression ISO cinnamaldehyde results in increased expression of LRP12 mRNA CTD PMID:19524605 NCBI chr 7:70,941,068...71,012,409 JBrowse link
G Lta lymphotoxin alpha increases expression ISO cinnamaldehyde results in increased expression of LTA mRNA CTD PMID:19000754 NCBI chr20:3,622,291...3,625,852 JBrowse link
G Magix MAGI family member, X-linked increases expression ISO cinnamaldehyde results in increased expression of MAGIX mRNA CTD PMID:19524605 NCBI chr  X:14,824,114...14,832,466 JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO cinnamaldehyde results in decreased expression of MAP2K2 mRNA CTD PMID:17178418 NCBI chr 7:9,241,449...9,264,216 JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 decreases phosphorylation EXP cinnamaldehyde results in decreased phosphorylation of MAP3K14 protein CTD PMID:17486422 NCBI chr10:88,665,417...88,715,669 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
EXP
ISO
cinnamaldehyde inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
cinnamaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein
cinnamaldehyde results in decreased phosphorylation of MAPK1 protein
cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]
CTD PMID:15964311 PMID:17486422 PMID:17868967 PMID:20060012 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
decreases phosphorylation
ISO
EXP
cinnamaldehyde results in increased phosphorylation of and results in increased activity of MAPK14 protein; pyrazolanthrone inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK14 protein]
cinnamaldehyde results in decreased phosphorylation of MAPK14 protein
CTD PMID:15964311 PMID:17486422 NCBI chr20:6,751,288...6,812,294 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
EXP
ISO
cinnamaldehyde inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]
cinnamaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein
cinnamaldehyde results in decreased phosphorylation of MAPK3 protein
CTD PMID:15964311 PMID:17486422 PMID:17868967 PMID:20060012 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO cinnamaldehyde results in increased phosphorylation of and results in increased activity of MAPK8 protein; pyrazolanthrone inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK8 protein]; SB 203580 inhibits the reaction [cinnamaldehyde results in increased phosphorylation of MAPK8 protein]
cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]
CTD PMID:15964311 PMID:17868967 PMID:21469739 NCBI chr16:8,645,171...8,728,225 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK9 protein] CTD PMID:17868967 NCBI chr10:34,670,750...34,711,972 JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 increases expression ISO cinnamaldehyde results in increased expression of MAPKAPK5 mRNA CTD PMID:19524605 NCBI chr12:40,654,220...40,673,740 JBrowse link
G Mark4 microtubule affinity regulating kinase 4 decreases expression ISO cinnamaldehyde results in decreased expression of MARK4 mRNA CTD PMID:17178418 NCBI chr 1:88,203,352...88,239,858 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO cinnamaldehyde results in decreased expression of MCL1 protein CTD PMID:15964311 NCBI chr 2:185,884,840...185,912,532 JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO cinnamaldehyde results in increased expression of MDM2 mRNA CTD PMID:19000754 NCBI chr 7:55,176,558...55,201,757 JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO cinnamaldehyde results in increased expression of MIF mRNA CTD PMID:11244134 NCBI chr20:12,790,919...12,791,784 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO cinnamaldehyde inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein] CTD PMID:28258635 NCBI chr19:30,327,643...30,355,856 JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO cinnamaldehyde results in increased expression of MMP3 mRNA CTD PMID:30806763 NCBI chr 8:12,925,267...12,938,828 JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions
ISO
EXP
cinnamaldehyde results in increased activity of MPO protein
cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]; Camphor inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]; Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]
CTD PMID:21466812 PMID:33522063 NCBI chr10:73,092,124...73,102,057 JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO cinnamaldehyde results in decreased expression of MX1 mRNA CTD PMID:19524605 NCBI chr11:36,799,659...36,825,209 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
ISO cinnamaldehyde results in increased expression of MYC mRNA
cinnamaldehyde results in decreased expression of MYC protein
CTD PMID:21729535 PMID:24211530 NCBI chr 7:95,483,105...95,488,031 JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; cinnamaldehyde inhibits the reaction [Poly I-C results in increased expression of MYD88 mRNA] CTD PMID:18306459 NCBI chr 8:127,952,161...127,956,230 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO cinnamaldehyde results in increased expression of NCF1 mRNA CTD PMID:19000754 NCBI chr12:28,121,816...28,131,080 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
affects response to substance
increases activity
multiple interactions
affects localization
affects expression
ISO cinnamaldehyde analog results in increased expression of NFE2L2 protein; cinnamaldehyde results in increased expression of NFE2L2 protein
NFE2L2 protein affects the susceptibility to cinnamaldehyde
cinnamaldehyde results in increased activity of NFE2L2 protein
cinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased abundance of Reactive Oxygen Species]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CCL3 mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CXCL1 mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CXCL10 mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of IL12A mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of IL1B mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of CAT mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX1 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX2 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX5 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX6 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GSR mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of NOS2 mRNA]
NFE2L2 affects the susceptibility to cinnamaldehyde
cinnamaldehyde affects the localization of NFE2L2 protein
[cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased glutathionylation of RELA protein; [ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of NFE2L2 protein; [NFE2L2 protein affects the susceptibility to cinnamaldehyde] which affects the expression of CXCL8 mRNA; [NFE2L2 protein affects the susceptibility to cinnamaldehyde] which affects the expression of IL1A mRNA; [NFE2L2 protein affects the susceptibility to cinnamaldehyde] which affects the expression of IL1B mRNA; [NFE2L2 protein affects the susceptibility to cinnamaldehyde] which affects the expression of IL23A mRNA; [NFE2L2 protein affects the susceptibility to cinnamaldehyde] which affects the expression of IL24 mRNA; [NFE2L2 protein affects the susceptibility to cinnamaldehyde] which affects the expression of IL6 mRNA; cinnamaldehyde results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 mRNA affects the reaction [cinnamaldehyde results in increased expression of GCLC protein]; NFE2L2 mRNA promotes the reaction [cinnamaldehyde results in increased expression of AKR1C2 mRNA]; NFE2L2 mRNA promotes the reaction [cinnamaldehyde results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of CXCL8 mRNA]; NFE2L2 protein affects the reaction [[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL1A mRNA]; NFE2L2 protein affects the reaction [[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL1B mRNA]; NFE2L2 protein affects the reaction [[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL23A mRNA]; NFE2L2 protein affects the reaction [[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL24 mRNA]; NFE2L2 protein affects the reaction [[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of IL6 mRNA]
cinnamaldehyde affects the expression of NFE2L2 protein
CTD PMID:18304597 PMID:18482591 PMID:19033392 PMID:20351055 PMID:21469739 More... NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO
EXP
cinnamaldehyde results in decreased expression of NFKB1 mRNA
cinnamaldehyde results in decreased expression of NFKB1 protein
CTD PMID:17486422 PMID:20385217 PMID:28219650 NCBI chr 2:226,689,745...226,805,897 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:20467561 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Ninl ninein-like increases expression ISO cinnamaldehyde results in increased expression of NINL mRNA CTD PMID:19524605 NCBI chr 3:139,748,353...139,814,683 JBrowse link
G Nos2 nitric oxide synthase 2 affects expression
multiple interactions
decreases expression
ISO
EXP
cinnamaldehyde affects the expression of NOS2 mRNA
cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of NOS2 mRNA]
cinnamaldehyde results in decreased expression of NOS2 protein
CTD PMID:17486422 PMID:20467561 PMID:28219650 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Notch3 notch receptor 3 increases expression ISO cinnamaldehyde results in increased expression of NOTCH3 mRNA CTD PMID:20713136 NCBI chr 7:11,132,984...11,184,025 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
increases activity
ISO cinnamaldehyde analog results in increased expression of NQO1 mRNA; cinnamaldehyde results in increased expression of NQO1 mRNA
[ethylhexadecyldimethylammonium co-treated with cinnamaldehyde] results in increased expression of NQO1 mRNA
cinnamaldehyde results in increased activity of NQO1 protein
CTD PMID:18482591 PMID:19033392 PMID:19524605 PMID:24211530 PMID:28219650 More... NCBI chr19:52,205,374...52,220,267 JBrowse link
G Nrf1 nuclear respiratory factor 1 decreases expression ISO cinnamaldehyde results in decreased expression of NRF1 mRNA CTD PMID:28219650 NCBI chr 4:58,664,932...58,772,328 JBrowse link
G Panx2 pannexin 2 increases expression ISO cinnamaldehyde results in increased expression of PANX2 mRNA CTD PMID:19524605 NCBI chr 7:120,139,259...120,153,056 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO cinnamaldehyde analog results in increased cleavage of PARP1 protein CTD PMID:16343908 NCBI chr13:94,839,484...94,871,295 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP cinnamaldehyde inhibits the reaction [Streptozocin results in increased expression of PCK1 mRNA] CTD PMID:20363216 NCBI chr 3:182,348,572...182,354,521 JBrowse link
G Pde3b phosphodiesterase 3B increases expression ISO cinnamaldehyde results in increased expression of PDE3B mRNA CTD PMID:19524605 NCBI chr 1:168,606,762...168,770,078 JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of PDK1 protein] CTD PMID:20467561 NCBI chr 3:77,113,464...77,144,145 JBrowse link
G Phlda2 pleckstrin homology-like domain, family A, member 2 increases expression ISO cinnamaldehyde results in increased expression of PHLDA2 mRNA CTD PMID:19524605 NCBI chr 1:198,696,897...198,699,292 JBrowse link
G Pir pirin increases expression ISO cinnamaldehyde results in increased expression of PIR mRNA CTD PMID:19524605 NCBI chr  X:33,740,428...33,851,049 JBrowse link
G Pklr pyruvate kinase L/R multiple interactions EXP cinnamaldehyde inhibits the reaction [Streptozocin results in decreased expression of PKLR mRNA] CTD PMID:20363216 NCBI chr 2:176,840,779...176,849,637 JBrowse link
G Pkm pyruvate kinase M1/2 increases metabolic processing ISO cinnamaldehyde results in increased metabolism of PKM protein CTD PMID:29267982 NCBI chr 8:68,949,731...68,975,394 JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO cinnamaldehyde inhibits the reaction [TGFB1 protein results in increased expression of PLAU protein] CTD PMID:28258635 NCBI chr15:3,505,485...3,511,987 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO cinnamaldehyde results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:62,255,970...62,262,384 JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO cinnamaldehyde results in increased expression of POR mRNA CTD PMID:19000754 NCBI chr12:26,587,674...26,655,612 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO cinnamaldehyde results in decreased expression of PPARG mRNA CTD PMID:21401097 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Ppbp pro-platelet basic protein multiple interactions
increases expression
ISO cinnamaldehyde results in increased expression of and results in increased secretion of PPBP protein
cinnamaldehyde results in increased expression of PPBP mRNA
CTD PMID:23624239 NCBI chr14:17,586,495...17,587,299 JBrowse link
G Ppfibp1 PPFIA binding protein 1 increases expression ISO cinnamaldehyde results in increased expression of PPFIBP1 mRNA CTD PMID:19524605 NCBI chr 4:179,807,579...179,951,428 JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO cinnamaldehyde results in decreased expression of PPP1R10 mRNA CTD PMID:17178418 NCBI chr20:2,827,802...2,842,418 JBrowse link
G Prdm5 PR/SET domain 5 increases expression ISO cinnamaldehyde results in increased expression of PRDM5 mRNA CTD PMID:19524605 NCBI chr 4:95,075,736...95,237,921 JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of cinnamaldehyde CTD PMID:11524419 NCBI chr 5:78,579,060...78,597,671 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
increases expression
ISO
EXP
cinnamaldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA]; cinnamaldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein]
cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
cinnamaldehyde inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]
cinnamaldehyde results in decreased expression of PTGS2 protein
cinnamaldehyde results in increased expression of PTGS2 mRNA
CTD PMID:16624280 PMID:17486422 PMID:17920563 PMID:21807015 PMID:30806763 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression EXP cinnamaldehyde results in decreased expression of RAC1 protein CTD PMID:17486422 NCBI chr12:16,150,411...16,170,864 JBrowse link
G Rbp4 retinol binding protein 4 multiple interactions EXP cinnamaldehyde inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr 1:235,893,917...235,901,315 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
increases glutathionylation
EXP
ISO
cinnamaldehyde results in decreased expression of RELA protein
cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of RELA protein]
cinnamaldehyde results in increased glutathionylation of RELA protein
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; [Cadmium Chloride affects the activity of GLRX protein] inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; [cinnamaldehyde results in increased abundance of Glutathione] which results in increased glutathionylation of RELA protein; [cinnamaldehyde results in increased abundance of Hydrogen Peroxide] which results in increased glutathionylation of RELA protein; [cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of GLRX protein] which results in increased glutathionylation of RELA protein; [cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased glutathionylation of RELA protein; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]; cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]; Dithiothreitol inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]
CTD PMID:17486422 PMID:20351055 PMID:32628957 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Rtn4rl1 reticulon 4 receptor-like 1 decreases expression ISO cinnamaldehyde results in decreased expression of RTN4RL1 mRNA CTD PMID:19524605 NCBI chr10:60,541,584...60,615,302 JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO cinnamaldehyde results in decreased expression of SCD1 mRNA CTD PMID:21401097 NCBI chr 1:253,218,968...253,232,101 JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO cinnamaldehyde results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr14:57,775,515...57,882,076 JBrowse link
G Serpinb3 serpin family B member 3 increases expression ISO cinnamaldehyde results in increased expression of SERPINB3 mRNA CTD PMID:30806763 NCBI chr13:23,274,120...23,280,660 JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO cinnamaldehyde results in increased expression of SERPINE1 mRNA CTD PMID:19000754 NCBI chr12:25,237,977...25,248,356 JBrowse link
G Sgcd sarcoglycan, delta increases expression ISO cinnamaldehyde results in increased expression of SGCD mRNA CTD PMID:19524605 NCBI chr10:31,346,480...32,328,364 JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) increases expression ISO cinnamaldehyde results in increased expression of SLC14A1 mRNA CTD PMID:19524605 NCBI chr18:71,565,453...71,608,807 JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression ISO cinnamaldehyde results in increased expression of SLC1A2 mRNA CTD PMID:19524605 NCBI chr 3:109,460,109...109,590,445 JBrowse link
G Slc26a7 solute carrier family 26 member 7 increases expression ISO cinnamaldehyde results in increased expression of SLC26A7 mRNA CTD PMID:19524605 NCBI chr 5:27,884,400...28,021,865 JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases activity
multiple interactions
ISO cinnamaldehyde results in increased activity of SLC2A1 protein
[cinnamaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein; Cysteine inhibits the reaction [[cinnamaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein]; Mercaptoethanol inhibits the reaction [[cinnamaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein]
CTD PMID:20955755 NCBI chr 5:138,002,522...138,030,742 JBrowse link
G Slc2a13 solute carrier family 2 member 13 increases expression ISO cinnamaldehyde results in increased expression of SLC2A13 mRNA CTD PMID:19524605 NCBI chr 7:122,399,329...122,726,605 JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP cinnamaldehyde inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein]; cinnamaldehyde inhibits the reaction [Streptozocin affects the localization of SLC2A4 protein] CTD PMID:19080170 PMID:20363216 NCBI chr10:55,164,721...55,170,289 JBrowse link
G Slc35d2 solute carrier family 35 member D2 decreases expression ISO cinnamaldehyde results in decreased expression of SLC35D2 mRNA CTD PMID:17178418 NCBI chr17:987,899...1,019,747 JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO cinnamaldehyde results in increased expression of SLC7A11 mRNA CTD PMID:17178418 PMID:24211530 PMID:30806763 NCBI chr 2:136,532,912...136,668,560 JBrowse link
G Slc8a1 solute carrier family 8 member A1 increases expression ISO cinnamaldehyde results in increased expression of SLC8A1 mRNA CTD PMID:19524605 NCBI chr 6:13,194,609...13,547,369 JBrowse link
G Smad2 SMAD family member 2 increases expression ISO cinnamaldehyde results in increased expression of SMAD2 mRNA CTD PMID:19524605 NCBI chr18:72,124,792...72,193,345 JBrowse link
G Snca synuclein alpha multiple interactions ISO cinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein] CTD PMID:31187328 NCBI chr 4:91,026,474...91,127,444 JBrowse link
G Snx24 sorting nexin 24 increases expression ISO cinnamaldehyde results in increased expression of SNX24 mRNA CTD PMID:19524605 NCBI chr18:46,670,987...46,826,070 JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SOCS3 protein] CTD PMID:33522063 NCBI chr10:103,692,579...103,695,975 JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO cinnamaldehyde results in decreased expression of SOD2 mRNA CTD PMID:28219650 NCBI chr 1:50,043,323...50,050,168 JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO cinnamaldehyde results in increased expression of SQSTM1 mRNA CTD PMID:24211530 NCBI chr10:35,026,598...35,037,750 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO dorsomorphin inhibits the reaction [cinnamaldehyde results in decreased expression of SREBF1 mRNA] CTD PMID:21401097 NCBI chr10:45,507,152...45,529,164 JBrowse link
G Srsf11 serine and arginine rich splicing factor 11 increases expression ISO cinnamaldehyde results in increased expression of SRSF11 mRNA CTD PMID:19524605 NCBI chr 2:247,074,623...247,101,460 JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO cinnamaldehyde results in increased expression of SRXN1 mRNA CTD PMID:19000754 NCBI chr 3:161,064,812...161,070,372 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of STAT3 protein modified form]; cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein] CTD PMID:32628957 PMID:33522063 NCBI chr10:86,311,528...86,363,513 JBrowse link
G Stau2 staufen double-stranded RNA binding protein 2 increases expression ISO cinnamaldehyde results in increased expression of STAU2 mRNA CTD PMID:19524605 NCBI chr 5:2,840,741...3,084,935 JBrowse link
G Stk24 serine/threonine kinase 24 decreases expression ISO cinnamaldehyde results in decreased expression of STK24 mRNA CTD PMID:19524605 NCBI chr15:104,770,556...104,866,524 JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling increases expression ISO cinnamaldehyde results in increased expression of SUFU mRNA CTD PMID:19524605 NCBI chr 1:255,199,108...255,296,983 JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO cinnamaldehyde results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr 6:100,272,729...100,586,364 JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions ISO cinnamaldehyde binds to and results in decreased activity of TBXA2R protein CTD PMID:17079160 NCBI chr 7:9,034,077...9,041,489 JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO cinnamaldehyde results in increased expression of TGFB1 mRNA
cinnamaldehyde inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; cinnamaldehyde inhibits the reaction [TGFB1 protein results in increased expression of PLAU protein]
CTD PMID:11244134 PMID:28258635 NCBI chr 1:90,324,312...90,340,627 JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 decreases expression ISO cinnamaldehyde results in decreased expression of TGFB1I1 mRNA CTD PMID:17178418 NCBI chr 1:182,828,553...182,835,465 JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO cinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] CTD PMID:31187328 NCBI chr 1:207,500,959...207,508,276 JBrowse link
G Thnsl2 threonine synthase-like 2 increases expression ISO cinnamaldehyde results in increased expression of THNSL2 mRNA CTD PMID:19524605 NCBI chr 4:103,112,974...103,132,122 JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO cinnamaldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA] CTD PMID:18306459 NCBI chr16:53,554,916...53,572,321 JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions
ISO cinnamaldehyde results in increased expression of TLR4 mRNA
cinnamaldehyde inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]
CTD PMID:17920563 PMID:18306459 PMID:19524605 NCBI chr 5:85,161,247...85,174,882 JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
[cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; cinnamaldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]; cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of TNF protein]; cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
cinnamaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; cinnamaldehyde inhibits the reaction [lipoteichoic acid results in increased secretion of TNF protein]
cinnamaldehyde results in increased expression of TNF mRNA
CTD PMID:17868967 PMID:20351055 PMID:20385217 PMID:20467561 PMID:21807015 More... NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 increases expression ISO cinnamaldehyde results in increased expression of TNFRSF21 mRNA CTD PMID:19524605 NCBI chr 9:17,879,156...17,954,085 JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO cinnamaldehyde results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr13:49,819,123...49,837,125 JBrowse link
G Tp53 tumor protein p53 decreases expression ISO cinnamaldehyde results in decreased expression of TP53 mRNA CTD PMID:17178418 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA] CTD PMID:18306459 NCBI chr 3:87,963,517...87,988,316 JBrowse link
G Trim16 tripartite motif-containing 16 increases expression ISO cinnamaldehyde results in increased expression of TRIM16 mRNA CTD PMID:17178418 PMID:19524605 NCBI chr10:47,485,982...47,509,010 JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
affects response to substance
increases response to substance
multiple interactions
EXP
ISO
cinnamaldehyde results in increased activity of TRPA1 protein
TRPA1 mRNA affects the susceptibility to cinnamaldehyde
TRPA1 protein results in increased susceptibility to cinnamaldehyde
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]; 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]; cinnamaldehyde binds to and results in increased activity of TRPA1 protein; isopentenyl pyrophosphate inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]
TRPA1 affects the susceptibility to cinnamaldehyde
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]; [cinnamaldehyde results in increased activity of TRPA1 protein] which results in increased transport of Calcium; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]; TRPA1 mRNA affects the reaction [cinnamaldehyde results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [cinnamaldehyde results in increased uptake of Calcium]
CTD PMID:15046718 PMID:17571167 PMID:17991581 PMID:19507004 PMID:20442136 More... NCBI chr 5:9,163,060...9,217,325 JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases expression EXP cinnamaldehyde results in increased expression of TRPV1 mRNA CTD PMID:20390747 NCBI chr10:58,349,936...58,375,021 JBrowse link
G Ttn titin decreases expression ISO cinnamaldehyde results in decreased expression of TTN mRNA CTD PMID:19000754 NCBI chr 3:82,059,648...82,332,130 JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO cinnamaldehyde results in increased expression of TXNRD1 mRNA; cinnamaldehyde results in increased expression of TXNRD1 protein CTD PMID:18304597 PMID:19000754 PMID:24211530 PMID:30806763 NCBI chr 7:22,717,620...22,802,553 JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases expression ISO cinnamaldehyde results in decreased expression of TXNRD2 mRNA CTD PMID:28219650 NCBI chr11:82,519,996...82,568,156 JBrowse link
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 increases expression ISO cinnamaldehyde results in increased expression of UBE2D1 mRNA CTD PMID:19524605 NCBI chr20:17,308,459...17,341,427 JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 increases expression ISO cinnamaldehyde results in increased expression of UGP2 mRNA CTD PMID:17178418 NCBI chr14:95,456,330...95,497,483 JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO cinnamaldehyde results in decreased expression of UNG mRNA CTD PMID:19000754 NCBI chr12:48,145,838...48,154,789 JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Acetylcysteine inhibits the reaction [cinnamaldehyde inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]]; cinnamaldehyde inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA] CTD PMID:35840659 NCBI chr14:84,604,623...84,609,707 JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP cinnamaldehyde inhibits the reaction [Testosterone results in increased activity of XDH protein modified form] CTD PMID:32628957 NCBI chr 6:21,530,463...21,592,172 JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases expression
ISO Vitamin E inhibits the reaction [cinnamaldehyde results in decreased expression of XIAP protein] CTD PMID:15566391 NCBI chr  X:125,756,107...125,803,979 JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 increases expression ISO cinnamaldehyde results in increased expression of ZDHHC21 mRNA CTD PMID:19524605 NCBI chr 5:97,227,621...97,286,866 JBrowse link
G Zfp639 zinc finger protein 639 increases expression ISO cinnamaldehyde results in increased expression of ZNF639 mRNA CTD PMID:19524605 NCBI chr 2:115,292,431...115,305,798 JBrowse link
4-dimethylaminocinnamaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [4-dimethylaminocinnamaldehyde co-treated with Adenosine Monophosphate] binds to ALDH1A1 protein CTD PMID:10609638 NCBI chr 1:218,000,470...218,152,962 JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member affects binding
multiple interactions
ISO 4-dimethylaminocinnamaldehyde binds to ALDH2 protein
acetophenone inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]; benzaldehyde inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]; phenacyl bromide inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]
CTD PMID:10609638 NCBI chr12:40,610,244...40,643,220 JBrowse link
alpha-hexylcinnamaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase affects expression ISO hexyl cinnamic aldehyde affects the expression of AICDA mRNA CTD PMID:22302311 NCBI chr 4:157,446,120...157,455,958 JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:63,899,222...63,913,315 JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO hexyl cinnamic aldehyde results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 4:64,005,632...64,027,860 JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of AKR1C1 mRNA CTD PMID:20566472 NCBI chr17:70,720,397...70,747,285 JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression
affects expression
ISO hexyl cinnamic aldehyde results in increased expression of AKR1C3 mRNA
hexyl cinnamic aldehyde affects the expression of AKR1C18 mRNA
CTD PMID:20566472 PMID:22302311 NCBI chr17:71,020,884...71,037,779 JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:105,274,103...105,331,653 JBrowse link
G Cat catalase increases expression ISO hexyl cinnamic aldehyde results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO hexyl cinnamic aldehyde results in increased secretion of CCL2 protein CTD PMID:22245253 NCBI chr10:67,503,077...67,504,875 JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO hexyl cinnamic aldehyde results in increased expression of CCL4 protein CTD PMID:18353026 NCBI chr10:68,963,893...68,965,728 JBrowse link
G Ccna2 cyclin A2 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCNA2 mRNA CTD PMID:22302311 NCBI chr 2:121,355,363...121,361,762 JBrowse link
G Ccnb1 cyclin B1 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCNB1 mRNA CTD PMID:22302311 NCBI chr 2:33,646,252...33,655,225 JBrowse link
G Ccne2 cyclin E2 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCNE2 mRNA CTD PMID:22302311 NCBI chr 5:29,082,169...29,094,879 JBrowse link
G Ccr4 C-C motif chemokine receptor 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCR4 mRNA CTD PMID:22302311 NCBI chr 8:114,176,291...114,182,033 JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO hexyl cinnamic aldehyde results in decreased expression of CCR7 protein CTD PMID:37326882 NCBI chr10:84,098,193...84,108,309 JBrowse link
G Cd160 CD160 molecule affects expression ISO hexyl cinnamic aldehyde affects the expression of CD160 mRNA CTD PMID:22302311 NCBI chr 2:184,340,820...184,383,421 JBrowse link
G Cd207 CD207 molecule affects expression ISO hexyl cinnamic aldehyde affects the expression of CD207 mRNA CTD PMID:22302311 NCBI chr 4:116,155,229...116,161,587 JBrowse link
G Cd5l Cd5 molecule-like affects expression ISO hexyl cinnamic aldehyde affects the expression of CD5L mRNA CTD PMID:22302311 NCBI chr 2:172,791,007...172,802,018 JBrowse link
G Cd80 Cd80 molecule multiple interactions
increases expression
ISO [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
hexyl cinnamic aldehyde results in increased expression of CD80 protein
CTD PMID:31958493 NCBI chr11:75,760,073...75,798,978 JBrowse link
G Cd83 CD83 molecule affects expression ISO hexyl cinnamic aldehyde affects the expression of CD83 mRNA CTD PMID:22302311 NCBI chr17:21,093,281...21,113,223 JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression
ISO [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of CD86 protein] CTD PMID:31958493 PMID:37326882 NCBI chr11:77,647,565...77,706,178 JBrowse link
G Cdc20 cell division cycle 20 affects expression ISO hexyl cinnamic aldehyde affects the expression of CDC20 mRNA CTD PMID:22302311 NCBI chr 5:137,251,596...137,255,799 JBrowse link
G Cdc25c cell division cycle 25C affects expression ISO hexyl cinnamic aldehyde affects the expression of CDC25C mRNA CTD PMID:22302311 NCBI chr18:26,608,483...26,630,292 JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of CDK1 mRNA CTD PMID:22302311 NCBI chr20:19,265,252...19,280,456 JBrowse link
G Cphx1 cytoplasmic polyadenylated homeobox 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of CPHX1 mRNA CTD PMID:22302311 NCBI chr16:1,533,883...1,537,248 JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of CTLA4 mRNA CTD PMID:22302311 NCBI chr 9:69,812,859...69,819,959 JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO hexyl cinnamic aldehyde results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr17:8,323,150...8,331,176 JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
decreases expression
ISO hexyl cinnamic aldehyde results in increased expression of CXCL2 mRNA; hexyl cinnamic aldehyde results in increased expression of CXCL2 protein
hexyl cinnamic aldehyde results in decreased expression of CXCL2 protein
CTD PMID:23178550 PMID:28826779 NCBI chr14:17,465,210...17,467,255 JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of CXCL1 mRNA CTD PMID:28826779 NCBI chr14:17,571,900...17,573,624 JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO hexyl cinnamic aldehyde results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:115,396,308...115,410,594 JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO hexyl cinnamic aldehyde results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608 JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of E2F1 mRNA CTD PMID:22302311 NCBI chr 3:163,524,739...163,535,563 JBrowse link
G Fabp7 fatty acid binding protein 7 affects expression ISO hexyl cinnamic aldehyde affects the expression of FABP7 mRNA CTD PMID:22302311 NCBI chr20:37,123,193...37,126,725 JBrowse link
G Fech ferrochelatase increases expression ISO hexyl cinnamic aldehyde results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,945,123...57,978,327 JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:105,072,858...105,074,705 JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of FXYD4 mRNA CTD PMID:22302311 NCBI chr 4:151,109,779...151,113,659 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO hexyl cinnamic aldehyde results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:157,352,364...157,372,144 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO hexyl cinnamic aldehyde results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO hexyl cinnamic aldehyde results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 2:213,032,135...213,052,192 JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr10:39,529,335...39,537,406 JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO hexyl cinnamic aldehyde results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Gzmb granzyme B affects expression ISO hexyl cinnamic aldehyde affects the expression of GZMB mRNA CTD PMID:22302311 NCBI chr15:30,343,352...30,346,814 JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of HMOX1 mRNA CTD PMID:20566472 PMID:26244607 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Ifng interferon gamma increases secretion ISO hexyl cinnamic aldehyde results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Il12b interleukin 12B affects expression ISO hexyl cinnamic aldehyde affects the expression of IL12B mRNA CTD PMID:22302311 NCBI chr10:29,390,300...29,405,194 JBrowse link
G Il17a interleukin 17A increases expression ISO hexyl cinnamic aldehyde results in increased expression of IL17A mRNA; hexyl cinnamic aldehyde results in increased expression of IL17A protein CTD PMID:28826779 NCBI chr 9:30,640,844...30,644,331 JBrowse link
G Il1a interleukin 1 alpha increases expression ISO hexyl cinnamic aldehyde results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:136,979,804...136,990,236 JBrowse link
G Il2 interleukin 2 increases secretion
increases expression
ISO hexyl cinnamic aldehyde results in increased secretion of IL2 protein
hexyl cinnamic aldehyde results in increased expression of IL2 protein
CTD PMID:22245253 PMID:22381623 NCBI chr 2:121,932,968...121,937,672 JBrowse link
G Il21 interleukin 21 affects expression ISO hexyl cinnamic aldehyde affects the expression of IL21 mRNA CTD PMID:22302311 NCBI chr 2:120,117,105...120,127,012 JBrowse link
G Il2ra interleukin 2 receptor subunit alpha affects expression ISO hexyl cinnamic aldehyde affects the expression of IL2RA mRNA CTD PMID:22302311 NCBI chr17:66,849,974...66,898,665 JBrowse link
G Il4 interleukin 4 affects expression
multiple interactions
ISO hexyl cinnamic aldehyde affects the expression of IL4 mRNA
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein
CTD PMID:22302311 PMID:31958493 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Il4r interleukin 4 receptor increases expression ISO hexyl cinnamic aldehyde results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 1:180,115,061...180,139,981 JBrowse link
G Il6 interleukin 6 increases secretion ISO hexyl cinnamic aldehyde results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Itgav integrin subunit alpha V affects expression ISO hexyl cinnamic aldehyde affects the expression of ITGAV mRNA CTD PMID:22302311 NCBI chr 3:89,245,382...89,333,512 JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr 7:112,792,787...112,804,139 JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:106,401,633...106,410,159 JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr12:14,834,628...14,856,414 JBrowse link
G Me1 malic enzyme 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:96,429,057...96,540,244 JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 4:171,029,666...171,044,893 JBrowse link
G Mir146a microRNA 146a increases expression
multiple interactions
ISO hexyl cinnamic aldehyde results in increased expression of MIR146A mRNA
PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of MIR146A mRNA]
CTD PMID:37326882 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Mir27a microRNA 27a decreases expression ISO hexyl cinnamic aldehyde results in decreased expression of MIR27A mRNA CTD PMID:37326882 NCBI chr19:23,954,831...23,954,917 JBrowse link
G Mki67 marker of proliferation Ki-67 affects expression ISO hexyl cinnamic aldehyde affects the expression of MKI67 mRNA CTD PMID:22302311 NCBI chr 1:199,926,150...199,952,847 JBrowse link
G Mmp10 matrix metallopeptidase 10 affects expression ISO hexyl cinnamic aldehyde affects the expression of MMP10 mRNA CTD PMID:22302311 NCBI chr 8:12,974,707...12,982,613 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Nts neurotensin affects expression ISO hexyl cinnamic aldehyde affects the expression of NTS mRNA CTD PMID:22302311 NCBI chr 7:37,564,944...37,574,350 JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO hexyl cinnamic aldehyde results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of CD86 protein]; PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of MIR146A mRNA] CTD PMID:37326882 NCBI chr 1:186,263,397...186,594,743 JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:78,579,060...78,597,671 JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 1:50,043,323...50,050,168 JBrowse link
G Sod3 superoxide dismutase 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr14:62,822,865...62,828,602 JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 3:161,064,812...161,070,372 JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of THBS1 mRNA CTD PMID:22302311 NCBI chr 3:125,510,250...125,525,402 JBrowse link
G Thbs4 thrombospondin 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of THBS4 mRNA CTD PMID:22302311 NCBI chr 2:23,983,158...24,025,289 JBrowse link
G Timd2 T-cell immunoglobulin and mucin domain containing 2 affects expression ISO hexyl cinnamic aldehyde affects the expression of TIMD2 mRNA CTD PMID:22302311 NCBI chr10:31,060,308...31,101,262 JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO hexyl cinnamic aldehyde results in increased expression of TNF mRNA
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein
CTD PMID:28826779 PMID:31958493 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 affects expression ISO hexyl cinnamic aldehyde affects the expression of TRPM6 mRNA CTD PMID:22302311 NCBI chr 1:225,559,528...225,747,106 JBrowse link
G Txn2 thioredoxin 2 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr 7:111,377,338...111,390,940 JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr 7:22,717,620...22,802,553 JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr11:82,519,996...82,568,156 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO hexyl cinnamic aldehyde results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 9:96,195,018...96,256,264 JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO hexyl cinnamic aldehyde results in increased expression of VEGFA protein CTD PMID:25617811 NCBI chr 9:22,452,854...22,468,194 JBrowse link
Cassiastearoptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions EXP 2-methoxycinnamaldehyde inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; 2-methoxycinnamaldehyde inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; 2-methoxycinnamaldehyde inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:17077517 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP 2-methoxycinnamaldehyde inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; 2-methoxycinnamaldehyde inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:17077517 NCBI chr13:64,714,063...64,722,320 JBrowse link
coniferyl aldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO coniferaldehyde results in increased expression of ABCC2 mRNA CTD PMID:26275128 NCBI chr 1:252,613,875...252,672,459 JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO coniferaldehyde results in increased expression of ABCC3 mRNA CTD PMID:26275128 NCBI chr10:79,793,571...79,839,528 JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions
increases expression
ISO NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]
coniferaldehyde results in increased expression of AKR1C1 mRNA; coniferaldehyde results in increased expression of AKR1C1 protein
CTD PMID:26275128 NCBI chr17:70,720,397...70,747,285 JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO coniferaldehyde results in increased expression of AKR1C2 mRNA; coniferaldehyde results in increased expression of AKR1C2 protein CTD PMID:26275128 NCBI chr17:70,669,684...70,717,935 JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO coniferaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:26275128 NCBI chr17:71,020,884...71,037,779 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO coniferaldehyde results in increased expression of GCLC mRNA CTD PMID:26275128 NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO coniferaldehyde results in increased expression of GCLM mRNA CTD PMID:26275128 NCBI chr 2:213,032,135...213,052,192 JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO coniferaldehyde results in increased expression of GSR mRNA
coniferaldehyde results in increased expression of GSR protein
CTD PMID:26275128 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]
coniferaldehyde results in increased expression of HMOX1 mRNA; coniferaldehyde results in increased expression of HMOX1 protein
CTD PMID:26275128 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Ifng interferon gamma multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]
CTD PMID:27378624 NCBI chr 1:236,408,905...236,468,769 JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr20:6,751,288...6,812,294 JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr13:45,066,027...45,112,326 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression
multiple interactions
ISO coniferaldehyde results in increased expression of MUC5AC mRNA
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; A 967079 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; coniferaldehyde results in increased expression of and results in increased secretion of MUC5AC protein; TWS 119 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]
CTD PMID:31944254 NCBI chr 1:206,293,717...206,326,006 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
ISO coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein; MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]
coniferaldehyde results in increased expression of NFE2L2 protein
CTD PMID:26275128 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
CTD PMID:27378624 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO coniferaldehyde results in increased expression of NQO1 protein CTD PMID:26275128 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Pkn3 protein kinase N3 multiple interactions ISO PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr 3:33,747,610...33,761,405 JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]
CTD PMID:27378624 NCBI chr 9:56,911,522...56,951,926 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO coniferaldehyde results in increased activity of TRPA1 protein CTD PMID:23541125 NCBI chr 5:9,163,060...9,217,325 JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO coniferaldehyde results in increased expression of TXNRD1 mRNA CTD PMID:26275128 NCBI chr 7:22,717,620...22,802,553 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      atom 19896
        nonmetal atom 19818
          carbon atom 19770
            organic molecular entity 19770
              olefinic compound 16992
                enal 3111
                  cinnamaldehydes 315
                    (E)-3-(2-Hydroxyphenyl)-2-propenal 0
                    (E)-cinnamaldehyde + 93
                    (E)-nesocodin (alcohol-form) zwitterion 0
                    (E)-nesocodin (oxo-form) zwitterion 0
                    (E)-sinapaldehyde + 0
                    (E)-sinapaldehyde 4-O-beta-D-glucopyranoside 0
                    (Z)-3-(2,4,5-Trimethoxyphenyl)-2-propenal 0
                    2-(Methylthiomethyl)-3-phenyl-2-propenal 0
                    2-Butyl-3-phenyl-2-propen-1-al 0
                    2-Methyl-3-phenyl-2-propenal 0
                    2-pentyl-3-phenyl-2-propenal 0
                    3,4,5-Trimethoxycinnamaldehyde 0
                    3,4-dihydroxycinnamaldehyde 0
                    3,4-dimethoxy cinnamaldehyde 0
                    3-(2,5-dihydroxyphenyl)prop-2-enal 0
                    3-(3,4,5-trimethoxyphenyl)-2-propenal 0
                    3-(4-Hydroxyphenyl)prop-2-enal 0
                    3-(4-Methoxyphenyl)-2-propenal 0
                    3-(4-Methylphenyl)-2-propenal 0
                    3-[4-Hydroxy-3-(3-methyl-2-butenyl)phenyl]-2-propenal 0
                    3-hydroxy-2-(phenylmethylidene)octanal 0
                    3-phenylprop-2-enal + 313
                    4-acetoxy cinnamaldehyde 0
                    4-acetoxy-3,5-dimethoxy-trans-cinnamaldehyde 0
                    4-acetoxy-3-methoxy-trans-cinnamaldehyde 0
                    4-dimethylaminocinnamaldehyde 2
                    4-hydroxycinnamaldehyde 0
                    Cassiastearoptene 2
                    Dillapional 0
                    Pentyl cinnamaldehyde 0
                    alpha-Amylcinnamaldehyde 0
                    alpha-hexylcinnamaldehyde 81
                    coniferyl aldehyde + 22
                    p-Methoxycinnamaldehyde 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      carboacyl group 17726
                                        univalent carboacyl group 17726
                                          formyl group 9386
                                            aldehyde 9386
                                              alpha,beta-unsaturated aldehyde 3111
                                                enal 3111
                                                  cinnamaldehydes 315
                                                    (E)-3-(2-Hydroxyphenyl)-2-propenal 0
                                                    (E)-cinnamaldehyde + 93
                                                    (E)-nesocodin (alcohol-form) zwitterion 0
                                                    (E)-nesocodin (oxo-form) zwitterion 0
                                                    (E)-sinapaldehyde + 0
                                                    (E)-sinapaldehyde 4-O-beta-D-glucopyranoside 0
                                                    (Z)-3-(2,4,5-Trimethoxyphenyl)-2-propenal 0
                                                    2-(Methylthiomethyl)-3-phenyl-2-propenal 0
                                                    2-Butyl-3-phenyl-2-propen-1-al 0
                                                    2-Methyl-3-phenyl-2-propenal 0
                                                    2-pentyl-3-phenyl-2-propenal 0
                                                    3,4,5-Trimethoxycinnamaldehyde 0
                                                    3,4-dihydroxycinnamaldehyde 0
                                                    3,4-dimethoxy cinnamaldehyde 0
                                                    3-(2,5-dihydroxyphenyl)prop-2-enal 0
                                                    3-(3,4,5-trimethoxyphenyl)-2-propenal 0
                                                    3-(4-Hydroxyphenyl)prop-2-enal 0
                                                    3-(4-Methoxyphenyl)-2-propenal 0
                                                    3-(4-Methylphenyl)-2-propenal 0
                                                    3-[4-Hydroxy-3-(3-methyl-2-butenyl)phenyl]-2-propenal 0
                                                    3-hydroxy-2-(phenylmethylidene)octanal 0
                                                    3-phenylprop-2-enal + 313
                                                    4-acetoxy cinnamaldehyde 0
                                                    4-acetoxy-3,5-dimethoxy-trans-cinnamaldehyde 0
                                                    4-acetoxy-3-methoxy-trans-cinnamaldehyde 0
                                                    4-dimethylaminocinnamaldehyde 2
                                                    4-hydroxycinnamaldehyde 0
                                                    Cassiastearoptene 2
                                                    Dillapional 0
                                                    Pentyl cinnamaldehyde 0
                                                    alpha-Amylcinnamaldehyde 0
                                                    alpha-hexylcinnamaldehyde 81
                                                    coniferyl aldehyde + 22
                                                    p-Methoxycinnamaldehyde 0
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