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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:SLC-0111
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Accession:CHEBI:232342 term browser browse the term
Definition:It is a potent carbonic anhydrase inhibitor (Ki = 45.1 nM and 4.5 nM for CA IX and CA XII, respectively) that is in clinical trials for the treatment of hypoxic malignancies .
Synonyms:exact_synonym: 4-{[(4-fluorophenyl)carbamoyl]amino}benzenesulfonamide
 related_synonym: 1-(4-fluorophenyl)-3-(4-sulfamoylphenyl)urea;   4-(4-fluorophenylureido)-benzenesulfonamide;   4-[3-(4-fluorophenyl)ureido]benzenesulfonamide;   4-{[(4-fluorophenyl)carbamoyl]amino}benzene-1-sulfonamide;   Formula=C13H12FN3O3S;   InChI=1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18);   InChIKey=YJQZNWPYLCNRLP-UHFFFAOYSA-N;   MST-104;   NSC-213841;   SLC0111;   SMILES=NS(=O)(=O)C1=CC=C(NC(=O)NC2=CC=C(F)C=C2)C=C1;   U-104;   U104;   WBI-5111
 xref: CAS:178606-66-1;   DrugBank:DB18815
 xref_mesh: MESH:C000625353
 xref: PDBeChem:WWZ;   PMCID:PMC5693064;   PMID:20922253;   PMID:26810836;   PMID:28347633;   PMID:28363153;   PMID:28947945;   PMID:29263302;   PMID:29962205;   PMID:30362384;   PMID:30445264;   PMID:30471577;   PMID:30978604;   PMID:32251122;   PMID:32396749;   PMID:32738591;   PMID:33667848;   PMID:33773285;   PMID:34221901;   PMID:34232641;   PMID:34871842;   PMID:34894950;   PMID:35328549;   PMID:35365193;   PMID:36146927;   PMID:36776327;   PMID:36982873;   PMID:37321108;   PMID:37501287;   PMID:37549770;   PMID:38713910;   PMID:39316272


show annotations for term's descendants           Sort by:
SLC-0111 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car12 carbonic anhydrase 12 decreases activity ISO SLC-0111 results in decreased activity of CA12 protein CTD PMID:28363153 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Car2 carbonic anhydrase 2 affects binding ISO SLC-0111 binds to CA2 protein CTD PMID:28363153 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car9 carbonic anhydrase 9 multiple interactions ISO SLC-0111 binds to and results in decreased activity of CA9 protein CTD PMID:28363153 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      application 19713
        pharmaceutical 19548
          drug 19548
            antineoplastic agent 17838
              SLC-0111 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  carbon oxoacid 18678
                                    carboxylic acid 18675
                                      carboacyl group 17725
                                        univalent carboacyl group 17725
                                          carbamoyl group 17577
                                            carboxamide 17577
                                              monocarboxylic acid amide 15750
                                                urea 6233
                                                  ureas 6231
                                                    phenylureas 2625
                                                      SLC-0111 3
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