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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3',4'-dimethoxyflavone
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Accession:CHEBI:232299 term browser browse the term
Synonyms:related_synonym: Formula=C17H14O4;   InChI=1S/C17H14O4/c1-19-15-8-7-11(9-17(15)20-2)16-10-13(18)12-5-3-4-6-14(12)21-16/h3-10H,1-2H3;   InChIKey=ZGHORMOOTZTQFL-UHFFFAOYSA-N;   SMILES=COC=1C=CC(=CC1OC)C2=CC(C3=CC=CC=C3O2)=O
 xref: CAS:4143-62-8;   HMDB:HMDB0246111
 xref_mesh: MESH:C509288



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3',4'-dimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression
ISO
EXP
3',4'-dimethoxyflavone binds to and results in decreased activity of AHR protein
3',4'-dimethoxyflavone results in decreased expression of AHR mRNA
3',4'-dimethoxyflavone inhibits the reaction [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein]
3',4'-dimethoxyflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of AHR mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of AHR protein]; 3',4'-dimethoxyflavone inhibits the reaction [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein]
CTD PMID:11099636 PMID:21908763 PMID:22138065 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO 3',4'-dimethoxyflavone analog affects the localization of AIFM1 protein CTD PMID:29630880 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator decreases expression
multiple interactions
ISO 3',4'-dimethoxyflavone results in decreased expression of ARNT protein
3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of ARNT protein]
CTD PMID:22138065 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO 3',4'-dimethoxyflavone analog results in decreased expression of and results in increased cleavage of BAX protein CTD PMID:29630880 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases cleavage ISO 3',4'-dimethoxyflavone analog results in increased cleavage of BCL2 protein CTD PMID:29630880 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 increases cleavage ISO 3',4'-dimethoxyflavone analog results in increased cleavage of CASP3 protein CTD PMID:29630880 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 decreases metabolic processing ISO 3',4'-dimethoxyflavone analog results in decreased metabolism of CASP4 protein CTD PMID:29630880 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp6 caspase 6 increases cleavage ISO 3',4'-dimethoxyflavone analog results in increased cleavage of CASP6 protein CTD PMID:29630880 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 increases cleavage ISO 3',4'-dimethoxyflavone analog results in increased cleavage of CASP7 protein CTD PMID:29630880 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 3',4'-dimethoxyflavone analog results in increased activity of and results in increased cleavage of CASP8 protein CTD PMID:29630880 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 3',4'-dimethoxyflavone analog results in increased activity of and results in increased cleavage of CASP9 protein CTD PMID:29630880 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions
increases expression
ISO 3',4'-dimethoxyflavone promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B1 mRNA]; 3',4'-dimethoxyflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [3',4'-dimethoxyflavone results in increased expression of CYP11B1 mRNA] CTD PMID:16396990 PMID:22172629 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression
multiple interactions
ISO 3',4'-dimethoxyflavone results in increased expression of CYP11B2 mRNA
3',4'-dimethoxyflavone promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA]
CTD PMID:16396990 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions
ISO 3',4'-dimethoxyflavone results in decreased activity of CYP1A1 protein
3',4'-dimethoxyflavone inhibits the reaction [7,8-dihydromethysticin results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [7,8-dihydromethysticin results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [methysticin results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [methysticin results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [Plant Extracts results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [Plant Extracts results in increased expression of CYP1A1 mRNA]
3',4'-dimethoxyflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [Plant Extracts results in increased expression of CYP1A1 mRNA]
CTD PMID:11099636 PMID:16396990 PMID:16484233 PMID:19794518 PMID:21053930 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
multiple interactions
ISO 3',4'-dimethoxyflavone results in decreased activity of CYP1A2 protein
3',4'-dimethoxyflavone affects the reaction [Tobacco Smoke Pollution analog results in increased expression of CYP1A2 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 protein]; 3',4'-dimethoxyflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
CTD PMID:21053930 PMID:26204831 PMID:28357125 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression
multiple interactions
ISO 3',4'-dimethoxyflavone results in decreased expression of CYP1B1 mRNA
3',4'-dimethoxyflavone binds to and results in decreased activity of CYP1B1 protein; 3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1B1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of CYP1B1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [butylbenzyl phthalate results in increased expression of CYP1B1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [Plant Extracts results in increased expression of CYP1B1 mRNA]
CTD PMID:16484233 PMID:16530937 PMID:17637178 PMID:19794518 PMID:19919601 More... NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO 3',4'-dimethoxyflavone results in decreased activity of CYP3A4 protein CTD PMID:21053930 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO 3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of EPHX1 protein] CTD PMID:16484233 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 multiple interactions ISO 3',4'-dimethoxyflavone inhibits the reaction [Cadmium results in increased expression of GALNT3 mRNA] CTD PMID:24614234 NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 multiple interactions ISO 3',4'-dimethoxyflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD17B7 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD17B7 protein] CTD PMID:27663891 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 3',4'-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; 3',4'-dimethoxyflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B protein] CTD PMID:15019843 PMID:24134915 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 multiple interactions ISO 3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of IL24 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of IL24 protein]; 3',4'-dimethoxyflavone inhibits the reaction [Particulate Matter results in increased expression of and results in increased secretion of IL24 protein]; 3',4'-dimethoxyflavone inhibits the reaction [Particulate Matter results in increased expression of IL24 mRNA] CTD PMID:28351761 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 3',4'-dimethoxyflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of IL6 protein]; 3',4'-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 PMID:27663891 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 3',4'-dimethoxyflavone analog results in increased phosphorylation of MAPK1 protein CTD PMID:29630880 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 3',4'-dimethoxyflavone analog results in increased phosphorylation of MAPK3 protein CTD PMID:29630880 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO 3',4'-dimethoxyflavone analog results in increased cleavage of PARP1 protein CTD PMID:29630880 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link

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  CHEBI ontology 19867
    chemical entity 19865
      atom 19865
        nonmetal atom 19787
          carbon atom 19740
            organic molecular entity 19740
              3',4'-dimethoxyflavone 26
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  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            3',4'-dimethoxyflavone 26
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