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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:silmitasertib
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Accession:CHEBI:232159 term browser browse the term
Synonyms:related_synonym: Formula=C19H12ClN3O2;   InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25);   InChIKey=MUOKSQABCJCOPU-UHFFFAOYSA-N;   SMILES=C1=CC(=CC(=C1)NC=2C3=CC=NC=C3C=4C=CC(=CC4N2)C(=O)O)Cl
 xref: CAS:1009820-21-6
 xref_mesh: MESH:C555142
 xref: PMID:27483355;   PMID:36630507;   Wikipedia:https://en.wikipedia.org/wiki/Silmitasertib


show annotations for term's descendants           Sort by:
silmitasertib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO silmitasertib results in decreased phosphorylation of AKT1 protein
[mirdametinib co-treated with silmitasertib] results in decreased phosphorylation of AKT1 protein; silmitasertib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; silmitasertib inhibits the reaction [Formaldehyde affects the phosphorylation of AKT1 protein]		 CTD PMID:21174434 PMID:25798061 PMID:36534342 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO silmitasertib results in decreased expression of BAX protein CTD PMID:25798061 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO silmitasertib results in decreased expression of BCL2L1 protein CTD PMID:25798061 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases phosphorylation
multiple interactions		 ISO silmitasertib results in decreased phosphorylation of CDKN1A protein
silmitasertib affects the expression of and results in decreased phosphorylation of CDKN1A protein		 CTD PMID:21174434 PMID:25798061 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions ISO silmitasertib affects the reaction [Formaldehyde affects the phosphorylation of CSNK2A1 protein]; silmitasertib inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]]; silmitasertib results in decreased activity of [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein] CTD PMID:21174434 PMID:36534342 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G Csnk2b casein kinase 2 beta multiple interactions ISO silmitasertib inhibits the reaction [Adenosine Triphosphate binds to [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein]]; silmitasertib results in decreased activity of [CSNK2A1 protein binds to CSNK2A1 protein binds to CSNK2B protein binds to CSNK2B protein] CTD PMID:21174434 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO silmitasertib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; silmitasertib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; silmitasertib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:36534342 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO [mirdametinib co-treated with silmitasertib] results in decreased expression of FOSL1 protein
silmitasertib results in increased expression of FOSL1 protein		 CTD PMID:25798061 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions ISO silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]] CTD PMID:34800614 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO silmitasertib results in increased expression of JUNB protein CTD PMID:25798061 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
affects phosphorylation		 ISO [mirdametinib co-treated with silmitasertib] results in decreased phosphorylation of MAPK1 protein; silmitasertib affects the reaction [Formaldehyde affects the phosphorylation of MAPK1 protein]; silmitasertib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]
silmitasertib results in increased phosphorylation of MAPK1 protein
silmitasertib affects the phosphorylation of MAPK1 protein		 CTD PMID:25798061 PMID:36534342 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
affects phosphorylation
multiple interactions		 ISO silmitasertib results in increased phosphorylation of MAPK3 protein
silmitasertib affects the phosphorylation of MAPK3 protein
[mirdametinib co-treated with silmitasertib] results in decreased phosphorylation of MAPK3 protein; silmitasertib affects the reaction [Formaldehyde affects the phosphorylation of MAPK3 protein]; silmitasertib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:25798061 PMID:36534342 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO silmitasertib results in increased expression of MKI67 protein CTD PMID:25798061 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation ISO silmitasertib results in decreased phosphorylation of RELA protein CTD PMID:25798061 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO silmitasertib results in decreased phosphorylation of RPS6 protein CTD PMID:25798061 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions ISO silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein] CTD PMID:34800614 NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Tp53 tumor protein p53 decreases expression
affects expression		 ISO silmitasertib results in decreased expression of TP53 protein
silmitasertib affects the expression of TP53 protein		 CTD PMID:25798061 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Yy1 YY1 transcription factor multiple interactions ISO silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein] CTD PMID:34800614 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    chemical entity 19865
      atom 19865
        nonmetal atom 19787
          carbon atom 19740
            organic molecular entity 19740
              silmitasertib 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            silmitasertib 18
paths to the root