CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: chlorophyllin
Accession: CHEBI:232141
browse the term
Synonyms: exact_synonym: magnesium;3-[20-(carboxylatomethyl)-18-(dioxidomethylidene)-8-ethenyl-13-ethyl-3,7,12,17-tetramethyl-2,3-dihydroporphyrin-23-id-2-yl]propanoate;hydron
related_synonym: Formula=C34H34N4O6.Mg; InChI=1S/C34H36N4O6.Mg/c1-7-19-15(3)23-12-25-17(5)21(9-10-29(39)40)32(37-25)22(11-30(41)42)33-31(34(43)44)18(6)26(38-33)14-28-20(8-2)16(4)24(36-28)13-27(19)35-23;/h7,12-14,17,21H,1,8-11H2,2-6H3,(H5,35,36,37,38,39,40,41,42,43,44);/q;+2/p-2; InChIKey=UVOXKYYHMDAWNK-UHFFFAOYSA-L; SMILES=C=CC1=C(C)C2=CC=3C(C)C(CCC(=O)[O-])C(=C(CC(=O)O)C=4C(=C(C)C(=CC5=C(CC)C(C)=C(C=C1[N-]2)N5)N4)C(=O)O)N3.[Mg+2]; magnesium chlorophyllin
xref: CAS:15611-43-5
xref_mesh: MESH:C007020
xref: Wikipedia:https://en.wikipedia.org/wiki/Chlorophyllin
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A4galt
alpha 1,4-galactosyltransferase
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of A4GALT mRNA]
CTD
PMID:19152381
NCBI chr 7:116,248,571...116,272,917
Ensembl chr 7:114,368,276...114,396,071
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Bex2
brain expressed X-linked 2
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of BEX1 mRNA]
CTD
PMID:19152381
NCBI chr X:103,811,458...103,812,986
Ensembl chr X:99,019,000...99,021,503
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C20h6orf15
similar to human chromosome 6 open reading frame 15
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of C6ORF15 mRNA]
CTD
PMID:19152381
NCBI chr20:3,172,330...3,173,886
Ensembl chr20:3,172,330...3,173,886
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Calr
calreticulin
decreases expression
ISO
chlorophyllin analog results in decreased expression of CALR protein
CTD
PMID:22852132
NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414
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Cat
catalase
multiple interactions
ISO
chlorophyllin inhibits the reaction [titanium dioxide results in increased activity of CAT protein]
CTD
PMID:25129858
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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Cct2
chaperonin containing TCP1 subunit 2
decreases expression
ISO
chlorophyllin analog results in decreased expression of CCT2 protein
CTD
PMID:22852132
NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
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Ctnnb1
catenin beta 1
multiple interactions
EXP
[chlorophyllin affects the reaction [1,2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein]; [chlorophyllin affects the reaction [2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein]; chlorophyllin affects the reaction [1,2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 gene]; chlorophyllin affects the reaction [2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene]
CTD
PMID:12628520
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
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Cxcl10
C-X-C motif chemokine ligand 10
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of CXCL10 mRNA]
CTD
PMID:19152381
NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases expression
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] chlorophyllin results in increased expression of CYP1A1 mRNA
CTD
PMID:19152381 PMID:20163913
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions increases expression
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] chlorophyllin results in increased expression of CYP1B1 mRNA
CTD
PMID:19152381 PMID:20163913
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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Dmc1
DNA meiotic recombinase 1
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of DMC1 mRNA]
CTD
PMID:19152381
NCBI chr 7:113,005,278...113,047,854
Ensembl chr 7:111,124,888...111,167,952
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Eif3i
eukaryotic translation initiation factor 3, subunit I
decreases expression
ISO
chlorophyllin analog results in decreased expression of EIF3I protein
CTD
PMID:22852132
NCBI chr 5:147,219,457...147,226,910
Ensembl chr 5:141,935,044...141,942,676
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Eno1
enolase 1
decreases expression
ISO
chlorophyllin analog results in decreased expression of ENO1 protein
CTD
PMID:22852132
NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336 Ensembl chr 3:160,719,951...160,731,336
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Gart
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
decreases expression
ISO
chlorophyllin analog results in decreased expression of GART protein
CTD
PMID:22852132
NCBI chr11:44,351,841...44,377,086
Ensembl chr11:30,865,889...30,891,125
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Glo1
glyoxalase 1
decreases expression
ISO
chlorophyllin analog results in decreased expression of GLO1 protein
CTD
PMID:22852132
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
EXP
[chlorophyllin affects the reaction [1,2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein]; [chlorophyllin affects the reaction [2-amino-3-methylimidazo(4,5-f)quinoline results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein]
CTD
PMID:12628520
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
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Hnrnph1
heterogeneous nuclear ribonucleoprotein H1
decreases expression
ISO
chlorophyllin analog results in decreased expression of HNRNPH1 protein
CTD
PMID:22852132
NCBI chr10:35,187,412...35,203,909
Ensembl chr10:34,693,555...34,702,846
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
chlorophyllin analog results in increased expression of HSPA5 protein
CTD
PMID:22852132
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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Ifi27
interferon, alpha-inducible protein 27
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFI27 mRNA]
CTD
PMID:19152381
NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:122,590,472...122,779,294
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Ifi30
IFI30, lysosomal thiol reductase
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFI30 mRNA]
CTD
PMID:19152381
NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175
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Ifit3
interferon-induced protein with tetratricopeptide repeats 3
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFIT3 mRNA]
CTD
PMID:19152381
NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:232,114,166...232,119,307
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Ifitm1
interferon induced transmembrane protein 1
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFITM1 mRNA]
CTD
PMID:19152381
NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:196,067,963...196,069,169
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Ifng
interferon gamma
multiple interactions
ISO
chlorophyllin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]
CTD
PMID:16275627
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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Igfbp3
insulin-like growth factor binding protein 3
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IGFBP3 mRNA]
CTD
PMID:19152381
NCBI chr14:86,270,208...86,277,944
Ensembl chr14:82,056,347...82,064,083
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Il12a
interleukin 12A
multiple interactions
ISO
chlorophyllin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]
CTD
PMID:16275627
NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734
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Il12b
interleukin 12B
multiple interactions
ISO
chlorophyllin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]
CTD
PMID:16275627
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
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Il12rb1
interleukin 12 receptor subunit beta 1
multiple interactions
ISO
chlorophyllin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12RB1 mRNA]
CTD
PMID:16275627
NCBI chr16:18,654,207...18,668,887
Ensembl chr16:18,620,770...18,632,769
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Il12rb2
interleukin 12 receptor subunit beta 2
multiple interactions
ISO
chlorophyllin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12RB2 mRNA]
CTD
PMID:16275627
NCBI chr 4:97,756,089...97,844,937
Ensembl chr 4:96,426,842...96,515,289
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Il1a
interleukin 1 alpha
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1A mRNA]
CTD
PMID:19152381
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
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Il22ra1
interleukin 22 receptor subunit alpha 1
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL22RA1 mRNA]
CTD
PMID:19152381
NCBI chr 5:153,245,067...153,269,865
Ensembl chr 5:147,961,349...147,986,296
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Impdh2
inosine monophosphate dehydrogenase 2
decreases expression
ISO
chlorophyllin analog results in decreased expression of IMPDH2 protein
CTD
PMID:22852132
NCBI chr 8:118,135,204...118,139,892
Ensembl chr 8:109,256,728...109,261,359
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Isg15
ISG15 ubiquitin-like modifier
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of ISG15 mRNA]
CTD
PMID:19152381
NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435
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Kl
Klotho
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of KL mRNA]
CTD
PMID:19152381
NCBI chr12:5,326,003...5,367,016
Ensembl chr12:490,399...530,080
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Krt10
keratin 10
increases expression
ISO
chlorophyllin analog results in increased expression of KRT10 protein
CTD
PMID:22852132
NCBI chr10:84,834,865...84,839,160
Ensembl chr10:84,338,706...84,343,701
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Map3k12
mitogen activated protein kinase kinase kinase 12
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of MAP3K12 mRNA]
CTD
PMID:19152381
NCBI chr 7:135,507,082...135,527,396
Ensembl chr 7:133,630,835...133,640,789
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Mx1
MX dynamin like GTPase 1
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of MX1 mRNA]
CTD
PMID:19152381
NCBI chr11:50,269,056...50,294,699
Ensembl chr11:36,799,660...36,823,507
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Nme1
NME/NM23 nucleoside diphosphate kinase 1
decreases expression
ISO
chlorophyllin analog results in decreased expression of NME1 protein
CTD
PMID:22852132
NCBI chr10:79,403,939...79,426,620
Ensembl chr10:78,906,083...78,916,408
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions increases expression
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA] chlorophyllin results in increased expression of NQO1 mRNA
CTD
PMID:19152381
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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Oas1a
2'-5' oligoadenylate synthetase 1A
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of OAS1 mRNA]
CTD
PMID:19152381
NCBI chr12:41,330,423...41,341,130
Ensembl chr12:35,669,801...35,680,517
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Oas2
2'-5' oligoadenylate synthetase 2
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of OAS2 mRNA]
CTD
PMID:19152381
NCBI chr12:41,464,568...41,492,036
Ensembl chr12:35,806,759...35,829,371
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Pcna
proliferating cell nuclear antigen
decreases expression
ISO
chlorophyllin analog results in decreased expression of PCNA protein
CTD
PMID:22852132
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
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Pgam1
phosphoglycerate mutase 1
decreases expression
ISO
chlorophyllin analog results in decreased expression of PGAM1 protein
CTD
PMID:22852132
NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:240,723,920...240,738,452
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Phgdh
phosphoglycerate dehydrogenase
decreases expression
ISO
chlorophyllin analog results in decreased expression of PHGDH protein
CTD
PMID:22852132
NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:185,906,966...185,935,944
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Pigz
phosphatidylinositol glycan anchor biosynthesis, class Z
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of PIGZ mRNA]
CTD
PMID:19152381
NCBI chr11:82,336,821...82,357,743
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Ppia
peptidylprolyl isomerase A
increases expression
ISO
chlorophyllin analog results in increased expression of PPIA protein
CTD
PMID:22852132
NCBI chr14:85,491,223...85,496,884
Ensembl chr14:81,275,091...81,299,601
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Ppm1f
protein phosphatase, Mg2+/Mn2+ dependent, 1F
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of PPM1F mRNA]
CTD
PMID:19152381
NCBI chr11:97,568,627...97,598,613
Ensembl chr11:84,064,420...84,094,340
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Prdx3
peroxiredoxin 3
decreases expression
ISO
chlorophyllin analog results in decreased expression of PRDX3 protein
CTD
PMID:22852132
NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:260,001,637...260,014,111
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Prdx6
peroxiredoxin 6
decreases expression
ISO
chlorophyllin analog results in decreased expression of PRDX6 protein
CTD
PMID:22852132
NCBI chr13:76,062,082...76,072,631
Ensembl chr13:73,528,210...73,539,355
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Rad23b
RAD23 homolog B, nucleotide excision repair protein
decreases expression
ISO
chlorophyllin analog results in decreased expression of RAD23B protein
CTD
PMID:22852132
NCBI chr 5:74,885,518...74,923,621
Ensembl chr 5:70,090,232...70,128,319
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Rad51d
RAD51 paralog D
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of RAD51D mRNA]
CTD
PMID:19152381
NCBI chr10:68,303,350...68,322,002
Ensembl chr10:67,740,712...67,824,434
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of STAT1 mRNA]
CTD
PMID:19152381
NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
chlorophyllin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT3 protein]
CTD
PMID:16275627
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
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Stat4
signal transducer and activator of transcription 4
multiple interactions
ISO
chlorophyllin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT4 protein]
CTD
PMID:16275627
NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:49,419,340...49,588,540
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Stmn1
stathmin 1
decreases expression
ISO
chlorophyllin analog results in decreased expression of STMN1 protein
CTD
PMID:22852132
NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:146,681,436...146,687,154
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Tnfsf13
TNF superfamily member 13
multiple interactions
ISO
chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNFSF13 mRNA]
CTD
PMID:19152381
NCBI chr10:54,898,805...54,901,815
Ensembl chr10:54,400,065...54,403,042
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Tp53
tumor protein p53
multiple interactions
ISO EXP
chlorophyllin inhibits the reaction [titanium dioxide results in increased mutagenesis of TRP53 exon] chlorophyllin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]
CTD
PMID:19227835 PMID:25129858
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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Tpt1
tumor protein, translationally-controlled 1
increases expression
ISO
chlorophyllin analog results in increased expression of TPT1 protein
CTD
PMID:22852132
NCBI chr15:57,562,217...57,568,968
Ensembl chr15:51,146,154...51,159,625
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Ube2n
ubiquitin-conjugating enzyme E2N
decreases expression
ISO
chlorophyllin analog results in decreased expression of UBE2N protein
CTD
PMID:22852132
NCBI chr 7:32,041,190...32,071,252
Ensembl chr 7:30,154,616...30,184,355
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