2-aminobiphenyl - Ontology Report

2-aminodiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]

PMID:18324785

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

Atf2

activating transcription factor 2

increases phosphorylation
multiple interactions

2-aminodiphenyl results in increased phosphorylation of ATF2 protein
2-aminodiphenyl results in increased expression of and results in increased phosphorylation of ATF2 protein; acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of ATF2 protein]; U 0126 inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of ATF2 protein]; U 0126 inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

Casp3

caspase 3

multiple interactions
increases activity

Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased activity of CASP3 protein]

PMID:23836369

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Cyba

cytochrome b-245 alpha chain

multiple interactions
increases expression

CYBA mutant form inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]
2-aminodiphenyl results in increased expression of CYBA protein

PMID:22288910

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

Jun

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

2-aminodiphenyl results in increased expression of and results in increased phosphorylation of JUN protein; 2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein; [U 0126 co-treated with pyrazolanthrone] inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein]; acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein]; JUN mutant form inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of JUN protein]; U 0126 inhibits the reaction [2-aminodiphenyl results in increased expression of and results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

Map2k1

mitogen activated protein kinase kinase 1

multiple interactions

MAP2K1 protein promotes the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]

PMID:22288910

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

Mapk1

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

2-aminodiphenyl results in increased phosphorylation of MAPK1 protein
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

Mapk3

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

2-aminodiphenyl results in increased phosphorylation of MAPK3 protein
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mapk8

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

2-aminodiphenyl results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK8 protein]

PMID:23836369

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

Mapk9

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK9 protein]

PMID:23836369

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

Ogg1

8-oxoguanine DNA glycosylase

decreases expression

2-aminodiphenyl results in decreased expression of OGG1 mRNA; 2-aminodiphenyl results in decreased expression of OGG1 protein

PMID:16112689

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

Ptgs2

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

2-aminodiphenyl results in increased expression of PTGS2 mRNA; 2-aminodiphenyl results in increased expression of PTGS2 protein
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; CYBA mutant form inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; diphenyleneiodonium inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; JUN mutant form inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; MAP2K1 protein promotes the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; pyrazolanthrone promotes the reaction [U 0126 inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]]; tanshinone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; U 0126 inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]