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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:BET bromodomain inhibitor
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Accession:CHEBI:231729 term browser browse the term
Definition:Any inhibitor of BET proteins.
Synonyms:related_synonym: BET bromodomain inhibitors;   BET inhibitor;   BET inhibitors;   Bromo- and Extra-Terminal domain inhibitor;   Bromo- and Extra-Terminal domain inhibitors
 xref: Wikipedia:BET_inhibitor


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molibresib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway decreases response to substance ISO APC mutant form results in decreased susceptibility to molibresib CTD PMID:26367796 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO molibresib results in increased expression of APOA1 mRNA; molibresib results in increased expression of APOA1 protein CTD PMID:21568322 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Car9 carbonic anhydrase 9 decreases expression
multiple interactions		 ISO molibresib results in decreased expression of CA9 mRNA
molibresib inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]		 CTD PMID:27292261 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Casp3 caspase 3 increases activity ISO molibresib results in increased activity of CASP3 protein CTD PMID:26911376 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity ISO molibresib results in increased activity of CASP7 protein CTD PMID:26911376 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO molibresib results in decreased expression of CCND1 mRNA CTD PMID:24874954 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO DKK1 protein inhibits the reaction [KMT2A protein results in decreased susceptibility to molibresib] CTD PMID:26367796 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression
multiple interactions		 ISO molibresib results in increased expression of EPAS1 mRNA
[Oxygen deficiency co-treated with molibresib] results in increased expression of EPAS1 mRNA		 CTD PMID:27292261 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO molibresib results in decreased expression of ESR1 mRNA CTD PMID:24874954 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 decreases expression ISO molibresib results in decreased expression of GREB1 mRNA CTD PMID:24874954 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Ifng interferon gamma multiple interactions ISO molibresib inhibits the reaction [IL15 protein results in increased expression of IFNG protein] CTD PMID:29301935 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il15 interleukin 15 multiple interactions ISO molibresib inhibits the reaction [IL15 protein results in increased expression of IFNG protein] CTD PMID:29301935 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Kmt2a lysine methyltransferase 2A multiple interactions
decreases response to substance		 ISO DKK1 protein inhibits the reaction [KMT2A protein results in decreased susceptibility to molibresib]; pyrvinium inhibits the reaction [KMT2A protein results in decreased susceptibility to molibresib] CTD PMID:26367796 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Lox lysyl oxidase multiple interactions
decreases expression		 ISO molibresib inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA]
molibresib results in decreased expression of LOX mRNA		 CTD PMID:27292261 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO molibresib inhibits the reaction [Oxygen deficiency results in increased expression of MYC mRNA] CTD PMID:27292261 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 increases expression
multiple interactions		 ISO molibresib results in increased expression of PFKFB3 mRNA
molibresib promotes the reaction [Oxygen deficiency results in increased expression of PFKFB3 mRNA]		 CTD PMID:27292261 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO molibresib results in decreased expression of TFF1 mRNA CTD PMID:24874954 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tmem45a transmembrane protein 45A multiple interactions ISO molibresib inhibits the reaction [Oxygen deficiency results in increased expression of TMEM45A mRNA] CTD PMID:27292261 NCBI chr11:43,713,309...43,799,526
Ensembl chr11:43,713,782...43,799,526 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions		 ISO molibresib results in decreased expression of VEGFA mRNA
molibresib inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]		 CTD PMID:27292261 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          BET bromodomain inhibitor 19
            I-BET151 0
            bromodomain-containing protein 4 inhibitor + 19
paths to the root