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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:SNC-80
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Accession:CHEBI:231727 term browser browse the term
Definition:A member of the class of alkylpiperazines that is piperazine substituted by (R)-[4-(diethylcarbamoyl)phenyl](3-methoxyphenyl)methyl, methyl, prop-1-en-3-yl, and methyl groups at positions 1, 2S, 4, and 5R, respectively. It is a delta-opioid receptor agonist that exhibits antidepressant, anxiolytic, analgesic, and antineoplastic activities.
Synonyms:exact_synonym: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-(prop-2-en-1-yl)piperazin-1-yl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide
 related_synonym: (+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide;   4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide;   Formula=C28H39N3O2;   InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1;   InChIKey=KQWVAUSXZDRQPZ-UMTXDNHDSA-N;   SMILES=[H][C@@](N1C[C@@H](C)N(CC=C)C[C@@H]1C)(C1=CC=C(C=C1)C(=O)N(CC)CC)C1=CC(OC)=CC=C1;   SNC80
 xref: CAS:156727-74-1
 xref_mesh: MESH:C088464
 xref: PMID:10340622;   PMID:10340623;   PMID:10841355;   PMID:10973516;   PMID:11400911;   PMID:11731107;   PMID:12717105;   PMID:15032699;   PMID:15102931;   PMID:15792997;   PMID:15936000;   PMID:15938001;   PMID:16334142;   PMID:16696856;   PMID:17061517;   PMID:18258789;   PMID:18469844;   PMID:22134006;   PMID:29278419;   PMID:29589835;   PMID:29727730;   PMID:31553899;   PMID:33516811;   PMID:35104493;   PMID:36708979;   PMID:37060527;   PMID:39064909;   PMID:7714789;   PMID:8035418;   PMID:9548393;   PMID:9694952;   PMID:9832942;   Wikipedia:SNC-80


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SNC-80 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        pharmacological role 19101
          analgesic 14794
            opioid analgesic 743
              SNC-80 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  carbon oxoacid 18678
                                    carboxylic acid 18675
                                      carboacyl group 17725
                                        univalent carboacyl group 17725
                                          carbamoyl group 17577
                                            carboxamide 17577
                                              monocarboxylic acid amide 15750
                                                arenecarboxamide 8262
                                                  benzamides 8262
                                                    SNC-80 1
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