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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:capmatinib
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Accession:CHEBI:231693 term browser browse the term
Definition:A member of the class of imidazotriazines that is imidazo[1,2-b][1,2,4]triazine substituted by 3-fluoro-4-(methylcarbamoyl)phenyl and quinolin-6-ylmethyl groups at positions 2 and 7, respectively. It is a c-Met receptor tyrosine kinase inhibitor used for the treatment of non-small cell lung cancer with MET exon 14 skipping mutation.
Synonyms:exact_synonym: 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
 related_synonym: Formula=C23H17FN6O;   INC-280;   INC280;   INCB-28060;   INCB-28060 free base;   INCB28060;   InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31);   InChIKey=LIOLIMKSCNQPLV-UHFFFAOYSA-N;   SMILES=CNC(=O)C1=C(F)C=C(C=C1)C1=NN2C(CC3=CC4=C(C=C3)N=CC=C4)=CN=C2N=C1
 xref: CAS:1197376-85-4;   DrugBank:DB11791;   HMDB:HMDB0249595;   KEGG:D10696
 xref_mesh: MESH:C000613976
 xref: PMID:27553677;   PMID:32665418;   PMID:36434677;   PMID:36457016;   PMID:37039616;   PMID:37157816;   PMID:37247365;   PMID:37509224;   PMID:37782740;   PMID:37923925;   PMID:37941971;   PMID:38025245;   PMID:38144528;   PMID:38524646;   PMID:38617599;   PMID:38762672;   PMID:38763104;   PMID:38776647;   PMID:38832711;   PMID:38849845;   PMID:38892160;   PMID:38941869;   PMID:38958204;   PMID:38962049;   PMID:38986421;   PMID:39068826;   PMID:39089913;   PMID:39091578;   PMID:39118880;   PMID:39136165;   PMID:39180576;   Wikipedia:Capmatinib


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capmatinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma multiple interactions ISO capmatinib inhibits the reaction [Diethylnitrosamine results in increased expression of and results in increased secretion of IFNG protein] CTD PMID:27553677 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO capmatinib inhibits the reaction [Diethylnitrosamine results in increased secretion of IL10 protein] CTD PMID:27553677 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO capmatinib inhibits the reaction [Diethylnitrosamine results in increased secretion of IL17A protein] CTD PMID:27553677 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO capmatinib inhibits the reaction [Diethylnitrosamine results in increased secretion of IL1B protein] CTD PMID:27553677 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO capmatinib inhibits the reaction [Diethylnitrosamine results in increased secretion of IL23A protein] CTD PMID:27553677 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO capmatinib results in increased expression of PCNA protein CTD PMID:27553677 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO capmatinib inhibits the reaction [Diethylnitrosamine results in increased expression of and results in increased secretion of TNF protein] CTD PMID:27553677 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        aetiopathogenetic role 19219
          hepatotoxic agent 16286
            capmatinib 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organochalcogen compound 19273
                                organooxygen compound 19189
                                  carbon oxoacid 18660
                                    carboxylic acid 18657
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17551
                                            carboxamide 17551
                                              monocarboxylic acid amide 15731
                                                arenecarboxamide 8257
                                                  benzamides 8257
                                                    capmatinib 7
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