Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:evofosfamide
go back to main search page
Accession:CHEBI:231678 term browser browse the term
Definition:A member of the class of imidazoles that is 1H-imidazole substituted by methyl, nitro, and ({bis[(2-bromoethyl)amino]phosphoryl}oxy)methyl groups at positions 1, 2 and 5, respectively. It is a hypoxia-activated prodrug that targets hypoxic regions of tumors. The drug was being evaluated for first-line treatment of advanced pancreatic adenocarcinoma and advanced soft tissue sarcoma, in combination with chemotherapy (phase 3 trial now discontinued since the drug did not meet primary endpoints).
Synonyms:exact_synonym: (1-methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate
 related_synonym: 2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine;   Formula=C9H16Br2N5O4P;   HAP-302;   InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/h6H,2-5,7H2,1H3,(H2,13,14,19);   InChIKey=UGJWRPJDTDGERK-UHFFFAOYSA-N;   SMILES=CN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr;   TH 302;   TH302;   evofosfamida;   evofosfamidum
 xref: CAS:918633-87-1;   DrugBank:DB06091;   KEGG:D10704
 xref_mesh: MESH:C552526
 xref: PMCID:PMC4903743;   PMCID:PMC5692401;   PMCID:PMC5692969;   PMCID:PMC6216171;   PMID:20530289;   PMID:26385861;   PMID:26749324;   PMID:26818215;   PMID:27248663;   PMID:27535748;   PMID:27752544;   PMID:28238078;   PMID:28741367;   PMID:28778024;   PMID:29764490;   PMID:29803017;   PMID:30134191;   PMID:30591421;   PMID:30979813;   PMID:31337055;   PMID:31431383;   PMID:32787454;   PMID:33096947;   PMID:33420361;   PMID:33504881;   PMID:33859749;   PMID:33918823;   PMID:33953675;   PMID:34011362;   PMID:34190375;   PMID:36226069;   PMID:37051681;   PMID:37988164;   PMID:37993847;   PMID:38030202;   PMID:38052529;   PMID:38067241;   PMID:38481819;   PMID:38745478;   PMID:38772123;   PMID:38992394;   Wikipedia:Evofosfamide


show annotations for term's descendants           Sort by:
evofosfamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione-disulfide reductase decreases activity ISO TH 302 results in decreased activity of GSR protein CTD PMID:19838642 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      application 19682
        pro-agent 11551
          prodrug 11295
            evofosfamide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      chalcogen 19555
                        oxygen atom 19527
                          oxygen molecular entity 19527
                            hydroxides 19336
                              oxoacid 18783
                                pnictogen oxoacid 14974
                                  phosphorus oxoacid 14574
                                    phosphoric acids 13924
                                      phosphoric acid 13924
                                        phosphoric acid derivative 13834
                                          phosphoric ester 13834
                                            phosphorodiamidate ester 1
                                              evofosfamide 1
paths to the root