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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:PF-06409577
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Accession:CHEBI:231658 term browser browse the term
Definition:A chloroindole that is 6-chloro-1H-indole substituted by carboxy and 4-(1-hydroxycyclobutyl)phenyl groups at positions 3 and 5, respectively. It is a potent and selective allosteric activator of AMPK and a potential treatment for diabetic nephropathy.
Synonyms:related_synonym: 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid;   Formula=C19H16ClNO3;   InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23);   InChIKey=FHQXLWCFSUSXBF-UHFFFAOYSA-N;   PF06409577;   SMILES=OC(=O)C1=CNC2=C1C=C(C(Cl)=C2)C1=CC=C(C=C1)C1(O)CCC1
 xref: CAS:1467057-23-3;   HMDB:HMDB0244646;   PDBeChem:6VT;   PMID:27490827;   PMID:28289077;   PMID:29673898;   PMID:29712653;   PMID:29733844;   PMID:30036059;   PMID:30194276;   PMID:32307703;   PMID:34336655;   PMID:35294578;   PMID:35748097;   PMID:36977628;   PMID:38026185


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Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      application 19713
        pharmaceutical 19549
          drug 19549
            antineoplastic agent 17838
              PF-06409577 0
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  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19725
                              organic cyclic compound 19517
                                organic heterocyclic compound 18894
                                  organic heteropolycyclic compound 18322
                                    organic heterobicyclic compound 17272
                                      benzopyrrole 9757
                                        indoles 9447
                                          haloindole 4
                                            chloroindole 0
                                              PF-06409577 0
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