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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Xmu-MP-1
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Accession:CHEBI:231615 term browser browse the term
Definition:Xmu-MP-1 is a MT1 and MT2 inhibitor.
Synonyms:related_synonym: 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide;   Formula=C17H16N6O3S2;   InChI=1S/C17H16N6O3S2/c1-22-12-7-8-27-14(12)16(24)23(2)13-9-19-17(21-15(13)22)20-10-3-5-11(6-4-10)28(18,25)26/h3-9H,1-2H3,(H2,18,25,26)(H,19,20,21);   InChIKey=YRDHKIFCGOZTGD-UHFFFAOYSA-N;   SMILES=CN1C2=C(C(=O)N(C3=CN=C(N=C31)NC4=CC=C(C=C4)S(=O)(=O)N)C)SC=C2;   XMU-MP1
 xref: CAS:2061980-01-4
 xref_mesh: MESH:C000625617



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Xmu-MP-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
ISO XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of ABCG2 mRNA]
XMU-MP-1 results in increased expression of ABCG2 mRNA
CTD PMID:31916386 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases activity ISO XMU-MP-1 results in increased activity of ALDH1 protein CTD PMID:31916386 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased expression of BAX protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased expression of BAX protein] CTD PMID:31044527 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of BCL2L1 protein] CTD PMID:31044527 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [XMU-MP-1 co-treated with U 0126 co-treated with pyrazolanthrone] inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; XMU-MP-1 inhibits the reaction [fisetin results in increased cleavage of CASP3 protein]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased cleavage of CASP3 protein] CTD PMID:31044527 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO [XMU-MP-1 co-treated with pyrazolanthrone co-treated with U 0126] inhibits the reaction [fisetin results in decreased expression of CCN2 protein]; XMU-MP-1 inhibits the reaction [fisetin results in decreased expression of CCN2 protein]
[XMU-MP-1 co-treated with Cadmium Chloride] results in increased expression of CCN2 mRNA; Verteporfin inhibits the reaction [[XMU-MP-1 co-treated with Cadmium Chloride] results in increased expression of CCN2 mRNA]
CTD PMID:31044527 PMID:35027733 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions ISO XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of EPCAM mRNA]; XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of EPCAM protein] CTD PMID:33405312 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of JUN protein] CTD PMID:31044527 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions ISO XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of KLF4 mRNA]; XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of KLF4 protein] CTD PMID:33405312 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Lats1 large tumor suppressor kinase 1 decreases phosphorylation ISO XMU-MP-1 results in decreased phosphorylation of LATS1 protein CTD PMID:35027733 NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 multiple interactions ISO XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased cleavage of CASP3 protein]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of JUN protein]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of MAPK1 protein]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of MAPK3 protein]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of YAP1 protein] CTD PMID:31044527 NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:31044527 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:31044527 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; XMU-MP-1 promotes the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]
XMU-MP-1 promotes the reaction [Cadmium Chloride results in increased expression of MT1A mRNA]; XMU-MP-1 promotes the reaction [zinc chloride results in increased expression of MT1A mRNA]
CTD PMID:35027733 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT2 mRNA]; XMU-MP-1 promotes the reaction [Cadmium Chloride results in increased expression of MT2 mRNA] CTD PMID:35027733 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Prom1 prominin 1 multiple interactions
increases expression
ISO XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of PROM1 mRNA]; XMU-MP-1 inhibits the reaction [Dichloroacetic Acid results in decreased expression of PROM1 protein]; XMU-MP-1 inhibits the reaction [ginsenoside Rg3 results in decreased expression of PROM1 mRNA]
XMU-MP-1 results in increased expression of PROM1 mRNA
CTD PMID:31916386 PMID:33405312 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Stk4 serine/threonine kinase 4 multiple interactions ISO XMU-MP-1 inhibits the reaction [licochalcone A results in increased expression of STK4 protein modified form] CTD PMID:34845814 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
JBrowse link
G Yap1 Yes1 associated transcriptional regulator decreases phosphorylation
multiple interactions
ISO XMU-MP-1 results in decreased phosphorylation of YAP1 protein
XMU-MP-1 inhibits the reaction [licochalcone A results in increased expression of YAP1 protein modified form]; XMU-MP-1 inhibits the reaction [MAP3K20 protein results in increased phosphorylation of YAP1 protein]
CTD PMID:31044527 PMID:34845814 PMID:35027733 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
JBrowse link

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      atom 19895
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              Xmu-MP-1 18
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                            Xmu-MP-1 18
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