chlorophenylethane - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	chlorophenylethane	go back to main search page
Accession:	CHEBI:23154	browse the term
Definition:	Any chlorohydrocarbon that is phenylethane substituted by at least one chloro group at unspecified position.
Synonyms:	related_synonym:	chlorophenylethanes

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Rat (668) Mouse (661) Human (694) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (668)

DDD

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activin A receptor type 1C

multiple interactions

[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ACVR1C mRNA

NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327

G

activin A receptor like type 1

multiple interactions

[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ACVRL1 mRNA

NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591

G

ALK receptor tyrosine kinase

multiple interactions

[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ALK mRNA; [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA

PMID:19422813 PMID:28263720

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

G

androgen receptor

affects binding
multiple interactions

Dichlorodiphenyldichloroethane binds to AR protein
Dichlorodiphenyldichloroethane inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Dichlorodiphenyldichloroethane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Dichlorodiphenyldichloroethane inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dihydrotestosterone analog inhibits the reaction [Dichlorodiphenyldichloroethane results in increased activity of AR protein]

PMID:14565775 PMID:14751673 PMID:15064155 PMID:21295777 PMID:26022396 More...

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

basic helix-loop-helix family, member a15

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA

NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713

G

catalase

multiple interactions

[Polychlorinated Biphenyls co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Chlordan co-treated with nonachlor] inhibits the reaction [Fish Oils results in increased expression of CAT mRNA]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

CREB binding protein

increases activity

Dichlorodiphenyldichloroethane results in increased activity of CREBBP protein

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

Dichlorodiphenyldichloroethane results in increased expression of CYP2B1 mRNA

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

Dichlorodiphenyldichloroethane results in increased expression of CYP2B6 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

Dichlorodiphenyldichloroethane results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

Dichlorodiphenyldichloroethane results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

Eph receptor A3

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA

NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900

G

Eph receptor A8

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA

NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399

G

erb-b2 receptor tyrosine kinase 3

multiple interactions

[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ERBB3 mRNA

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

estrogen receptor 1

increases activity
multiple interactions
increases expression

Dichlorodiphenyldichloroethane analog results in increased activity of ESR1 protein; Dichlorodiphenyldichloroethane results in increased activity of ESR1 protein
Dichlorodiphenyldichloroethane binds to and results in increased activity of ESR1 protein
Dichlorodiphenyldichloroethane results in increased expression of ESR1 mRNA

PMID:15064155 PMID:21295777 PMID:26022396 PMID:33049310

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases activity

Dichlorodiphenyldichloroethane analog results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

GDNF family receptor alpha 1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA

NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of KIT mRNA; [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA

PMID:19422813 PMID:28263720

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

leucine rich repeat containing 2

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA

NCBI chr 8:110,936,119...110,969,189
Ensembl chr 8:110,938,165...110,969,185

G

MER proto-oncogene, tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA

NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Dichlorodiphenyldichloroethane binds to and results in increased activity of NR1I2 protein

PMID:20686338 PMID:21115097 PMID:33049310

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases activity

Dichlorodiphenyldichloroethane results in increased activity of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

neurotrophic receptor tyrosine kinase 1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

platelet derived growth factor receptor alpha

multiple interactions

[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNA

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

platelet derived growth factor receptor beta

multiple interactions

[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRB mRNA; [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA

PMID:19422813 PMID:28263720

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

progesterone receptor

multiple interactions

Dichlorodiphenyldichloroethane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

plexin D1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA

NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Dichlorodiphenyldichloroethane binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

increases expression

Dichlorodiphenyldichloroethane results in increased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

ret proto-oncogene

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA

NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176

G

solute carrier family 18 member A2

multiple interactions

Dichlorodiphenyldichloroethane inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 6 member 3

multiple interactions

Dichlorodiphenyldichloroethane inhibits the reaction [DAT protein results in increased uptake of Dopamine]

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

superoxide dismutase 1

multiple interactions

[Polychlorinated Biphenyls co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Chlordan co-treated with nonachlor] inhibits the reaction [Fish Oils results in increased expression of SOD1 mRNA]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

thyroid hormone receptor beta

multiple interactions

Dichlorodiphenyldichloroethane binds to and results in decreased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

DDT

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

decreases expression
multiple interactions

DDT results in decreased expression of ABCA1 protein
DDT inhibits the reaction [T0901317 results in increased expression of ABCA1 protein]

PMID:25720399 PMID:34045954

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

decreases activity
increases expression

DDT metabolite results in decreased activity of ABCB1 protein
DDT results in increased expression of ABCB1 mRNA

PMID:15710169 PMID:23169446 PMID:24464585 PMID:29477483

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

increases expression

DDT results in increased expression of ABCC2 mRNA

PMID:24464585 PMID:31521043

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

decreases methylation

DDT results in decreased methylation of ABCC3 gene

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily G member 2

decreases activity

DDT metabolite results in decreased activity of ABCG2 protein

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

actin-binding LIM protein 1

increases methylation

DDT results in increased methylation of ABLIM1 gene

NCBI chr 1:256,083,747...256,372,075
Ensembl chr 1:256,084,297...256,371,969

G

acetyl-CoA acetyltransferase 1

decreases expression

DDT results in decreased expression of ACAT1 mRNA; DDT results in decreased expression of ACAT1 protein

NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855

G

angiotensin I converting enzyme

decreases expression

DDT results in decreased expression of ACE mRNA

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acetylcholinesterase

increases expression

DDT results in increased expression of ACHE mRNA

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acyl-CoA synthetase bubblegum family member 2

decreases methylation

DDT results in decreased methylation of ACSBG2 gene

NCBI chr 9:1,683,846...1,715,517
Ensembl chr 9:1,683,847...1,714,518

G

acyl-CoA synthetase short-chain family member 2

increases expression

DDT results in increased expression of ACSS2 mRNA

NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675

G

acyl-CoA synthetase short-chain family member 3

decreases expression

DDT results in decreased expression of ACSS3 mRNA

NCBI chr 7:42,241,261...42,450,209
Ensembl chr 7:42,242,652...42,450,230

G

actin alpha 2, smooth muscle

increases expression

DDT results in increased expression of ACTA2 mRNA

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, beta

decreases expression

DDT results in decreased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin gamma 2, smooth muscle

increases expression

DDT results in increased expression of ACTG2 mRNA

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

ADAM metallopeptidase with thrombospondin type 1 motif, 5

decreases expression

DDT results in decreased expression of ADAMTS5 mRNA

NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205

G

ArfGAP with dual PH domains 2

decreases methylation

DDT results in decreased methylation of ADAP2 gene

NCBI chr10:65,138,006...65,166,147
Ensembl chr10:65,138,020...65,165,604

G

androglobin

increases methylation

DDT results in increased methylation of ADGB gene

NCBI chr 1:4,753,621...4,896,268
Ensembl chr 1:4,753,621...4,896,190

G

adrenoceptor beta 2

affects activity

DDT affects the activity of ADRB2 protein

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

ALF transcription elongation factor 2

increases methylation

DDT results in increased methylation of AFF2 gene

NCBI chr X:147,928,130...148,432,484
Ensembl chr X:147,928,407...148,429,995

G

alkylglycerol monooxygenase

increases methylation

DDT results in increased methylation of AGMO gene

NCBI chr 6:53,986,236...54,317,838
Ensembl chr 6:53,986,292...54,317,623

G

aryl hydrocarbon receptor

multiple interactions
decreases expression
affects binding

[indole-3-carbinol co-treated with DDT] results in increased expression of AHR mRNA
DDT results in decreased expression of AHR mRNA
DDT binds to AHR protein

PMID:17311112 PMID:20436506 PMID:31521043

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1 member B10

increases expression

DDT results in increased expression of AKR1B10 mRNA

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

5'-aminolevulinate synthase 1

increases expression

DDT results in increased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

albumin

decreases expression

DDT results in decreased expression of ALB mRNA

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

activated leukocyte cell adhesion molecule

decreases expression

DDT results in decreased expression of ALCAM mRNA

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

ALK receptor tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

G

alkaline phosphatase, biomineralization associated

multiple interactions

DDT inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

alkaline phosphatase, placental

decreases methylation

DDT results in decreased methylation of AKP3 gene

NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606

G

Aly/REF export factor

increases methylation

DDT results in increased methylation of ALYREF gene

NCBI chr10:105,871,424...105,875,076
Ensembl chr10:105,871,306...105,875,069

G

anaphase promoting complex subunit 11

increases methylation

DDT results in increased methylation of ANAPC11 gene

NCBI chr10:105,875,209...105,886,307

G

ankyrin 3

increases methylation

DDT results in increased methylation of ANK3 gene

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

ankyrin repeat and sterile alpha motif domain containing 1B

increases methylation

DDT results in increased methylation of ANKS1B gene

NCBI chr 7:24,313,339...25,479,307
Ensembl chr 7:24,312,843...25,477,693

G

anoctamin 3

decreases methylation

DDT results in decreased methylation of ANO3 gene

NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154

G

alanyl aminopeptidase, membrane

decreases expression

DDT results in decreased expression of ANPEP mRNA

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

ANTXR cell adhesion molecule 1

increases methylation

DDT results in increased methylation of ANTXR1 gene

NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232

G

annexin A1

decreases expression

DDT results in decreased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A13

decreases methylation

DDT results in decreased methylation of ANXA13 gene

NCBI chr 7:89,884,356...89,936,907
Ensembl chr 7:89,884,356...89,936,907

G

adaptor related protein complex 2 subunit alpha 2

increases methylation

DDT results in increased methylation of AP2A2 gene

NCBI chr 1:196,652,315...196,725,609
Ensembl chr 1:196,652,337...196,725,603

G

apolipoprotein E

affects expression
increases expression

DDT affects the expression of APOE mRNA
DDT results in increased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

amyloid beta precursor protein

increases expression
multiple interactions
affects expression

DDT results in increased expression of APP mRNA; DDT results in increased expression of APP protein
Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA]; Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP protein]
DDT affects the expression of APP mRNA
DDT results in increased expression of and results in increased cleavage of APP protein mutant form; DDT results in increased expression of and results in increased secretion of and results in decreased degradation of APP protein modified form; Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA]

PMID:24473795 PMID:25720399 PMID:35946953

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

androgen receptor

multiple interactions
decreases expression
affects binding

[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Hydrocarbons, Chlorinated] inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; DDT binds to and results in decreased activity of AR protein; DDT inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; DDT inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; DDT inhibits the reaction [Dihydrotestosterone binds to AR protein]; DDT inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; DDT inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; DDT inhibits the reaction [Metribolone affects the localization of AR protein]; DDT inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; DDT inhibits the reaction [Metribolone results in increased expression of AR protein]; Dihydrotestosterone inhibits the reaction [DDT results in increased activity of AR protein]
DDT results in decreased expression of AR mRNA
DDT binds to AR protein

PMID:9705896 PMID:14565775 PMID:14579009 PMID:15064155 PMID:15483189 More...

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

decreases expression

DDT results in decreased expression of ARAP2 mRNA

NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154

G

ARF GTPase 1

decreases expression

DDT results in decreased expression of ARF1 mRNA

NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434

G

ARF guanine nucleotide exchange factor 1

decreases expression

DDT results in decreased expression of ARFGEF1 mRNA

NCBI chr 5:8,982,061...9,076,326
Ensembl chr 5:8,981,540...9,076,326

G

Rho GTPase activating protein 10

increases methylation

DDT results in increased methylation of ARHGAP10 gene

NCBI chr19:30,448,572...30,710,315
Ensembl chr19:30,448,637...30,710,313

G

Rho GTPase activating protein 15

decreases methylation

DDT results in decreased methylation of ARHGAP15 gene

NCBI chr 3:27,989,368...28,592,722
Ensembl chr 3:27,989,633...28,600,265

G

Rho GTPase activating protein 31

increases methylation

DDT results in increased methylation of ARHGAP31 gene

NCBI chr11:62,038,635...62,151,564
Ensembl chr11:62,038,635...62,151,564

G

Rho GTPase activating protein 5

decreases expression

DDT results in decreased expression of ARHGAP5 mRNA

NCBI chr 6:69,975,904...70,039,299
Ensembl chr 6:69,976,214...70,037,660

G

Rho GTPase activating protein 6

decreases expression

DDT results in decreased expression of ARHGAP6 mRNA

NCBI chr X:24,953,464...25,490,003
Ensembl chr X:24,953,464...25,488,663

G

Rho guanine nucleotide exchange factor 33

increases methylation

DDT results in increased methylation of ARHGEF33 gene

NCBI chr 6:14,582,922...14,715,014
Ensembl chr 6:14,551,495...14,725,292

G

ARF like GTPase 2

decreases expression

DDT results in decreased expression of ARL2 mRNA

NCBI chr 1:203,434,129...203,446,156
Ensembl chr 1:203,434,129...203,446,119

G

arylsulfatase B

decreases methylation

DDT results in decreased methylation of ARSB gene

NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671

G

activating transcription factor 3

increases expression

DDT results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of ATP1A1 mRNA

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase H+ transporting V1 subunit C2

decreases methylation

DDT results in decreased methylation of ATP6V1C2 gene

NCBI chr 6:40,080,545...40,144,199
Ensembl chr 6:40,080,547...40,120,028

G

attractin like 1

increases methylation

DDT results in increased methylation of ATRNL1 gene

NCBI chr 1:256,670,976...257,219,291
Ensembl chr 1:256,670,627...257,213,197

G

beta-secretase 1

increases expression
decreases expression

DDT results in increased expression of BACE1; DDT results in increased expression of BACE1 mRNA
DDT results in decreased expression of BACE1 mRNA

PMID:25720399 PMID:35946953

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

B-cell receptor-associated protein 29

decreases expression

DDT results in decreased expression of BCAP29 mRNA

NCBI chr 6:48,182,702...48,222,698
Ensembl chr 6:48,182,706...48,222,720

G

branched chain amino acid transaminase 1

decreases expression

DDT results in decreased expression of BCAT1 mRNA

NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597

G

butyrylcholinesterase

decreases expression

DDT results in decreased expression of BCHE mRNA

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[DDT results in increased activity of ESR1 protein] which results in increased expression of BCL2 mRNA
DDT results in decreased expression of BCL2 protein

PMID:22403704 PMID:28263910

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL6, transcription repressor

increases expression

DDT results in increased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

brain-derived neurotrophic factor

multiple interactions

[Permethrin co-treated with DDT co-treated with Diethylstilbestrol] inhibits the reaction [Potassium results in increased expression of BDNF mRNA]; DDT inhibits the reaction [Potassium results in increased expression of BDNF mRNA]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

biglycan

increases expression

DDT results in increased expression of BGN mRNA

NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461

G

basic helix-loop-helix family, member a15

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA

NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713

G

baculoviral IAP repeat-containing 6

increases methylation

DDT results in increased methylation of BIRC6 gene

NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434

G

Bcl2 modifying factor

decreases expression

DDT results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

biorientation of chromosomes in cell division 1-like 1

decreases expression

DDT results in decreased expression of BOD1L1 mRNA

NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490

G

bromodomain containing 9

decreases methylation

DDT results in decreased methylation of BRD9 gene

NCBI chr 1:29,329,981...29,357,285
Ensembl chr 1:29,329,985...29,357,016

G

BTG anti-proliferation factor 2

increases expression

DDT results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

similar to human chromosome 1 open reading frame 21

increases methylation

DDT results in increased methylation of C13H1ORF21 gene

NCBI chr13:63,982,587...64,199,676
Ensembl chr13:63,990,592...64,199,596

G

calcium voltage-gated channel subunit alpha1 A

increases methylation

DDT results in increased methylation of CACNA1A gene

NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225

G

calcium voltage-gated channel auxiliary subunit alpha2delta 3

decreases methylation

DDT results in decreased methylation of CACNA2D3 gene

NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351

G

calcium dependent secretion activator

decreases expression

DDT results in decreased expression of CADPS mRNA

NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779

G

calbindin 2

increases expression

DDT results in increased expression of CALB2 mRNA

NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438

G

calcitonin receptor like receptor

increases methylation

DDT results in increased methylation of CALCRL gene

NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910

G

caldesmon 1

decreases expression

DDT results in decreased expression of CALD1 mRNA

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calcium homeostasis modulator family member 2

decreases expression

DDT results in decreased expression of CALHM2 mRNA

NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218

G

calcium/calmodulin-dependent protein kinase II delta

increases methylation

DDT results in increased methylation of CAMK2D gene

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

G

calnexin

decreases expression

DDT results in decreased expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

calpain 2

increases methylation

DDT results in increased methylation of CAPN2 gene

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

carbonic anhydrase 10

decreases methylation

DDT results in decreased methylation of CAR10 gene

NCBI chr10:78,055,875...78,556,490
Ensembl chr10:78,054,114...78,555,834

G

cardiac mesoderm enhancer-associated non-coding RNA

increases expression

DDT results in increased expression of CARMN mRNA

NCBI chr18:55,097,848...55,118,769
Ensembl chr18:55,095,230...55,118,825

G

caspase 3

increases activity
multiple interactions
decreases activity

DDT results in increased activity of CASP3 protein
SB 203580 inhibits the reaction [DDT results in increased activity of CASP3 protein]
DDT inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]
DDT results in decreased activity of CASP3 protein

PMID:10200566 PMID:15603917

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity
multiple interactions

DDT results in increased activity of CASP7 protein
SB 203580 inhibits the reaction [DDT results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

catalase

multiple interactions

[Polychlorinated Biphenyls co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Chlordan co-treated with nonachlor] inhibits the reaction [Fish Oils results in increased expression of CAT mRNA]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cerebellin 1 precursor

decreases expression

DDT results in decreased expression of CBLN1 mRNA

NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572

G

coiled-coil domain containing 85A

decreases methylation

DDT results in decreased methylation of CCDC85A gene

NCBI chr14:102,126,574...102,359,207
Ensembl chr14:102,129,029...102,359,058

G

cellular communication network factor 2

decreases expression

DDT results in decreased expression of CCN2 mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin D1

multiple interactions
increases expression

DDT promotes the reaction [ESR1 protein binds to CCND1 promoter]; DDT promotes the reaction [FOS protein binds to CCND1 promoter]
Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of CCND1 protein]
DDT results in increased expression of CCND1 protein
DDT results in increased expression of CCND1 mRNA; DDT results in increased expression of CCND1 protein

PMID:8927716 PMID:9049186 PMID:23684557 PMID:24968063

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

decreases expression

DDT results in decreased expression of CCND2 mRNA

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

C-C motif chemokine receptor 7

increases methylation

DDT results in increased methylation of CCR7 gene

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

CD244 molecule

increases methylation

DDT results in increased methylation of CD244 gene

NCBI chr13:84,051,339...84,082,864
Ensembl chr13:84,052,493...84,074,492

G

CD2-associated protein

decreases expression

DDT results in decreased expression of CD2AP mRNA

NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199

G

CD34 molecule

increases expression

DDT results in increased expression of CD34 mRNA

NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832

G

CD86 molecule

multiple interactions

DDT inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CD86 protein]

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cell division cycle associated 2

increases methylation

DDT results in increased methylation of CDCA2 gene

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cadherin 1

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]; DDT inhibits the reaction [CDH1 protein binds to CTNNB1 protein]; ruxolitinib inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]; WP1066 inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]
DDT results in decreased expression of CDH1 mRNA; DDT results in decreased expression of CDH1 protein

PMID:22902829 PMID:24820114

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [DDT results in increased expression of CDH2 mRNA]; ruxolitinib inhibits the reaction [DDT results in increased expression of CDH2 mRNA]; WP1066 inhibits the reaction [DDT results in increased expression of CDH2 mRNA]

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin dependent kinase 2

increases activity
multiple interactions

DDT results in increased activity of CDK2 protein
DDT results in increased phosphorylation of and results in increased activity of CDK2 protein; fulvestrant inhibits the reaction [DDT results in increased phosphorylation of and results in increased activity of CDK2 protein]

PMID:8927716 PMID:9049186 PMID:9168006

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

increases expression

DDT results in increased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
decreases expression

DDT inhibits the reaction [TRP53 protein binds to CDKN1A promoter]; DDT promotes the reaction [ESR1 protein binds to CDKN1A promoter]
DDT results in decreased expression of CDKN1A mRNA

PMID:23684557 PMID:33728745

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

decreases expression
increases methylation

DDT results in decreased expression of CDKN2A mRNA alternative form; DDT results in decreased expression of CDKN2A protein alternative form
DDT results in increased methylation of CDKN2A promoter alternative form

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

CCAAT/enhancer binding protein alpha

multiple interactions

DDT results in increased activity of and results in increased localization of CEBPA protein

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

cell migration inducing hyaluronidase 1

decreases expression

DDT results in decreased expression of CEMIP mRNA

NCBI chr 1:137,906,921...138,062,430
Ensembl chr 1:137,908,920...138,062,415

G

centromere protein C

increases methylation

DDT results in increased methylation of CENPC gene

NCBI chr14:21,988,067...22,046,732
Ensembl chr14:21,988,144...22,055,476

G

centrosomal protein 170B

increases methylation

DDT results in increased methylation of CEP170B gene

NCBI chr 6:131,780,935...131,806,658
Ensembl chr 6:131,778,957...131,806,658

G

carboxylesterase 1D

increases methylation

DDT results in increased methylation of CES1D gene

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 3a

increases expression

DDT results in increased expression of CES3 mRNA

NCBI chr19:32,992,386...33,000,562

G

CF transmembrane conductance regulator

multiple interactions

DDT inhibits the reaction [S-Nitrosoglutathione results in increased expression of and results in increased stability of CFTR protein]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

glycoprotein hormones, alpha polypeptide

multiple interactions
increases expression

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased expression of CGA mRNA]
DDT inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]; DDT inhibits the reaction [CGA protein results in increased secretion of Progesterone]; DDT promotes the reaction [[CGA protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]

PMID:24814263 PMID:26895433 PMID:33638691

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

G

chimerin 1

increases methylation

DDT results in increased methylation of CHN1 gene

NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490

G

cholinergic receptor, muscarinic 1

increases expression

DDT results in increased expression of CHRM1 mRNA; DDT results in increased expression of CHRM1 protein

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 3

increases expression

DDT results in increased expression of CHRM3 mRNA; DDT results in increased expression of CHRM3 protein

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 4

multiple interactions

[DDT co-treated with bioallethrin] results in increased expression of CHRM4 mRNA

NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor nicotinic alpha 1 subunit

increases expression

DDT results in increased expression of CHRNA1 mRNA; DDT results in increased expression of CHRNA1 protein

NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840

G

carbohydrate sulfotransferase 15

increases methylation

DDT results in increased methylation of CHST15 gene

NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707

G

cytoplasmic linker associated protein 2

decreases methylation

DDT results in decreased methylation of CLASP2 gene

NCBI chr 8:113,677,345...113,859,957
Ensembl chr 8:113,677,284...113,858,731

G

C-type lectin domain containing 16A

decreases methylation

DDT results in decreased methylation of CLEC16A gene

NCBI chr10:4,927,799...5,123,749
Ensembl chr10:4,928,030...5,123,578

G

C-type lectin domain family 2, member M

increases methylation

DDT results in increased methylation of CLEC2M gene

NCBI chr 4:162,768,988...162,779,951
Ensembl chr 4:162,768,994...162,779,899

G

CAP-GLY domain containing linker protein family, member 4

increases methylation

DDT results in increased methylation of CLIP4 gene

NCBI chr 6:23,616,280...23,697,625
NCBI chr 6:23,718,580...23,729,231
NCBI chr 6:23,597,729...23,601,000
Ensembl chr 6:23,616,281...23,677,874

G

calsyntenin 2

decreases expression

DDT results in decreased expression of CLSTN2 mRNA

NCBI chr 8:98,020,406...98,637,232
Ensembl chr 8:98,021,666...98,637,731

G

clusterin

decreases expression

DDT results in decreased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

C-x(9)-C motif containing 1

increases methylation

DDT results in increased methylation of CMC1 gene

NCBI chr 8:117,798,036...117,900,458
Ensembl chr 8:117,798,945...117,900,462

G

Cnksr family member 3

decreases methylation

DDT results in decreased methylation of CNKSR3 gene

NCBI chr 1:43,499,273...43,591,630
Ensembl chr 1:43,499,487...43,591,635

G

collagen type XI alpha 1 chain

decreases expression

DDT results in decreased expression of COL11A1 mRNA

NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853

G

collagen type I alpha 1 chain

increases expression

DDT results in increased expression of COL1A1 mRNA

PMID:22902829 PMID:30207508

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

increases expression

DDT results in increased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 1 chain

increases expression

DDT results in increased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type IV alpha 5 chain

decreases expression

DDT results in decreased expression of COL4A5 mRNA

NCBI chr X:105,118,762...105,322,699
Ensembl chr X:105,118,820...105,322,692

G

collagen type VI alpha 1 chain

increases expression

DDT results in increased expression of COL6A1 mRNA

NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597

G

collagen type VI alpha 2 chain

increases expression

DDT results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

coenzyme Q2, polyprenyltransferase

increases methylation

DDT results in increased methylation of COQ2 gene

NCBI chr14:8,941,429...8,961,418
Ensembl chr14:8,941,461...8,960,891

G

coronin 6

increases expression

DDT results in increased expression of CORO6 mRNA

NCBI chr10:62,311,552...62,319,659
Ensembl chr10:62,311,660...62,319,659

G

carboxypeptidase E

decreases expression

DDT results in decreased expression of CPE mRNA

NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233

G

cAMP responsive element binding protein 1

increases activity

DDT results in increased activity of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element binding protein 3-like 1

increases expression

DDT results in increased expression of CREB3L1 mRNA

NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456

G

CREB binding protein

increases activity

DDT results in increased activity of CREBBP protein

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

cysteine rich transmembrane BMP regulator 1

decreases expression

DDT results in decreased expression of CRIM1 mRNA

NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259

G

carnitine O-octanoyltransferase

decreases methylation

DDT results in decreased methylation of CROT gene

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109

G

cone-rod homeobox

decreases methylation

DDT results in decreased methylation of CRX gene

NCBI chr 1:76,539,812...76,553,694
Ensembl chr 1:76,540,141...76,545,818

G

cysteine and serine rich nuclear protein 3

increases methylation

DDT results in increased methylation of CSRNP3 gene

NCBI chr 3:50,498,379...50,695,598
Ensembl chr 3:50,498,633...50,685,950

G

catenin alpha 2

decreases expression

DDT results in decreased expression of CTNNA2 mRNA

NCBI chr 4:109,294,249...110,443,409
Ensembl chr 4:109,293,978...110,443,522

G

catenin alpha 3

decreases expression

DDT results in decreased expression of CTNNA3 mRNA

NCBI chr20:23,614,469...25,200,026
Ensembl chr20:23,623,560...25,199,978

G

catenin beta 1

multiple interactions
affects localization
increases expression

Acetylcysteine inhibits the reaction [DDT results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; DDT inhibits the reaction [CDH1 protein binds to CTNNB1 protein]; DDT results in increased expression of and results in decreased phosphorylation of CTNNB1 protein
DDT affects the localization of CTNNB1 protein
DDT results in increased expression of CTNNB1 protein

PMID:22902829 PMID:24968063

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

multiple interactions

[DDT results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

C-X-C motif chemokine ligand 12

increases expression

DDT results in increased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

DDT results in increased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases expression
multiple interactions

DDT results in increased expression of CYP17A1 mRNA
fulvestrant inhibits the reaction [DDT results in increased expression of CYP17A1 mRNA]

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases expression
increases expression
increases activity

DDT results in decreased expression of CYP19A1 mRNA
DDT results in increased expression of CYP19A1 mRNA
DDT results in increased activity of CYP19A1 protein

PMID:12035542 PMID:28263910 PMID:30817981

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases expression
increases expression

[indole-3-carbinol co-treated with DDT] results in increased expression of CYP1A1 mRNA; aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; nobiletin inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]
DDT results in decreased expression of CYP1A1 mRNA
[Polychlorinated Biphenyls co-treated with DDT co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of CYP1A1 mRNA

PMID:16036770 PMID:17311112 PMID:20865247 PMID:28263910 PMID:29477483 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

DDT results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

[indole-3-carbinol co-treated with DDT] results in increased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily a, polypeptide 1

increases expression

DDT results in increased expression of CYP2A1 mRNA

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily a, polypeptide 2

increases expression

DDT results in increased expression of CYP2A2 mRNA

NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions
increases activity
increases expression

[DDT co-treated with Diethylnitrosamine] results in decreased expression of CYP2B1 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of CYP2B1 mRNA
DDT results in increased activity of CYP2B1 protein
DDT results in increased expression of CYP2B1 protein

PMID:1372805 PMID:7595932 PMID:11948501 PMID:12597452 PMID:15729006 More...

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions
increases expression

[DDT co-treated with Diethylnitrosamine] results in decreased expression of CYP2B2 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA
DDT results in increased expression of CYP2B2 protein

PMID:7595932 PMID:15885732

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions
decreases expression

DDT results in increased expression of CYP2B6 mRNA; DDT results in increased expression of CYP2B6 protein
[Androstanols co-treated with Fulvestrant] inhibits the reaction [DDT results in increased expression of CYP2B10 mRNA]; Androstanols inhibits the reaction [DDT results in increased expression of CYP2B10 mRNA]; DDT promotes the reaction [GADD45B protein binds to CYP2B10 promoter]; DDT promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]; DDT promotes the reaction [PPARGC1A protein binds to CYP2B10 promoter]
DDT results in decreased expression of CYP2B3 mRNA
[CYP2B6 gene SNP affects the susceptibility to DDT] which affects the abundance of Dichlorodiphenyl Dichloroethylene; CYP2B6 gene SNP affects the reaction [DDT results in increased abundance of Dichlorodiphenyl Dichloroethylene]

PMID:15548381 PMID:20686338 PMID:23684557 PMID:27839851 PMID:29477483

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily d, polypeptide 1

decreases expression

DDT results in decreased expression of CYP2D1 mRNA

NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084

G

cytochrome P450, family 2, subfamily t, polypeptide 1

increases methylation

DDT results in increased methylation of CYP2T1 gene

NCBI chr 1:82,446,321...82,451,564
Ensembl chr 1:82,446,921...82,451,563

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression

[DDT co-treated with Diethylnitrosamine] results in decreased expression of CYP3A2 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of CYP3A2 mRNA
DDT results in increased expression of CYP3A4 mRNA; DDT results in increased expression of CYP3A4 protein
[DDT co-treated with Dieldrin] results in increased expression of CYP3A4 mRNA

PMID:15548381 PMID:15885732 PMID:17035600 PMID:20686338 PMID:25028461

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

CYFIP related Rac1 interactor A

decreases expression

DDT results in decreased expression of CYRIA mRNA

NCBI chr 6:35,045,208...35,150,669
Ensembl chr 6:35,045,208...35,150,668

G

dachshund family transcription factor 1

decreases expression

DDT results in decreased expression of DACH1 mRNA

NCBI chr15:74,528,122...74,909,811
Ensembl chr15:74,529,208...74,909,922

G

DNA cross-link repair 1C

increases methylation

DDT results in increased methylation of DCLRE1C gene

NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186

G

DEF6 guanine nucleotide exchange factor

increases methylation

DDT results in increased methylation of DEF6 gene

NCBI chr20:6,268,579...6,290,030
Ensembl chr20:6,268,601...6,289,961

G

desmin

increases expression

DDT results in increased expression of DES mRNA

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

DExH-box helicase 29

decreases methylation

DDT results in decreased methylation of DHX29 gene

NCBI chr 2:44,560,653...44,611,450
Ensembl chr 2:44,560,714...44,611,445

G

discs large MAGUK scaffold protein 4

decreases expression

DDT results in decreased expression of DLG4 protein

NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153

G

distal-less homeobox 5

increases expression

DDT results in increased expression of DLX5 mRNA

NCBI chr 4:34,999,139...35,003,504
Ensembl chr 4:34,999,139...35,003,407

G

dystrophin

increases methylation

DDT results in increased methylation of DMD gene

NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207

G

DnaJ heat shock protein family (Hsp40) member C15

increases expression

DDT results in increased expression of DNAJC15 mRNA

NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675

G

DnaJ heat shock protein family (Hsp40) member C3

increases methylation

DDT results in increased methylation of DNAJC3 gene

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

DNA methyltransferase 1

decreases expression
increases expression

DDT results in decreased expression of DNMT1 mRNA
DDT results in increased expression of DNMT1 mRNA; DDT results in increased expression of DNMT1 protein

PMID:19797855 PMID:25410620

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

decreases expression

DDT results in decreased expression of DNMT3A mRNA

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

decreases expression

DDT results in decreased expression of DNMT3B mRNA

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

docking protein 5

increases methylation

DDT results in increased methylation of DOK5 gene

NCBI chr 3:159,515,886...159,652,811
Ensembl chr 3:159,515,893...159,652,810

G

dpy-19 like 2

decreases methylation

DDT results in decreased methylation of DPY19L2 gene

NCBI chr 8:23,062,592...23,181,817
Ensembl chr 8:23,063,115...23,181,798

G

dihydropyrimidine dehydrogenase

increases methylation

DDT results in increased methylation of DPYD gene

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

dystonin

increases methylation

DDT results in increased methylation of DST gene

NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615

G

denticleless E3 ubiquitin protein ligase homolog

decreases methylation

DDT results in decreased methylation of DTL gene

NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890

G

dymeclin

increases methylation

DDT results in increased methylation of DYM gene

NCBI chr18:68,605,131...68,900,905
Ensembl chr18:68,605,185...68,900,903

G

dual specificity tyrosine phosphorylation regulated kinase 2

decreases methylation

DDT results in decreased methylation of DYRK2 gene

NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106

G

E2F transcription factor 1

increases expression
multiple interactions

DDT results in increased expression of E2F1 mRNA; DDT results in increased expression of E2F1 protein
fulvestrant inhibits the reaction [DDT results in increased expression of E2F1 mRNA]

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

EBNA1 binding protein 2

increases expression

DDT results in increased expression of EBNA1BP2 mRNA

NCBI chr 5:132,148,164...132,152,730
Ensembl chr 5:132,148,143...132,153,267

G

endothelin converting enzyme-like 1

decreases methylation

DDT results in decreased methylation of ECEL1 gene

NCBI chr 9:87,819,516...87,829,154
Ensembl chr 9:87,816,718...87,826,675

G

estrogen-induced osteoclastogenesis regulator 1

increases expression

DDT results in increased expression of EEIG1 mRNA

NCBI chr 3:15,822,441...15,854,651
Ensembl chr 3:15,823,144...15,854,643

G

epidermal growth factor

multiple interactions

[EGF protein co-treated with DDT] results in increased expression of MYC mRNA

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

EGF-like, fibronectin type III and laminin G domains

increases expression

DDT results in increased expression of EGFLAM mRNA

NCBI chr 2:56,301,945...56,476,665
Ensembl chr 2:56,302,566...56,476,298

G

egl-9 family hypoxia-inducible factor 2

increases methylation

DDT results in increased methylation of EGLN2 gene

NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751

G

early growth response 1

decreases expression
increases expression

DDT results in decreased expression of EGR1 mRNA
DDT results in increased expression of EGR1 mRNA

PMID:25014179 PMID:30207508

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

increases expression

DDT results in increased expression of EGR2 mRNA

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

eukaryotic translation initiation factor 4A2

increases expression

DDT results in increased expression of EIF4A2 mRNA

NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781

G

ETS transcription factor ELK1

increases activity

DDT results in increased activity of ELK1 protein

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

elastin microfibril interfacer 2

increases expression

DDT results in increased expression of EMILIN2 mRNA

NCBI chr 9:111,160,708...111,220,463
Ensembl chr 9:111,160,712...111,220,352

G

engrailed homeobox 2

increases methylation

DDT results in increased methylation of EN2 gene

NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943

G

ectodermal-neural cortex 1

decreases expression
increases expression

DDT results in decreased expression of ENC1 mRNA
DDT results in increased expression of ENC1 mRNA

PMID:19797855 PMID:30207508

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

enolase 1

decreases expression

DDT results in decreased expression of ENO1 protein

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

ectonucleotide pyrophosphatase/phosphodiesterase 3

decreases methylation

DDT results in decreased methylation of ENPP3 gene

NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041

G

endothelial PAS domain protein 1

decreases expression

DDT results in decreased expression of EPAS1 mRNA

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

Eph receptor A3

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA

NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900

G

Eph receptor A4

decreases methylation

DDT results in decreased methylation of EPHA4 gene

NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139

G

Eph receptor A8

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA

NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399

G

epoxide hydrolase 1

increases activity

DDT results in increased activity of EPHX1 protein

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

erb-b2 receptor tyrosine kinase 2

increases phosphorylation

DDT results in increased phosphorylation of ERBB2 protein

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

esterase D

increases expression

DDT results in increased expression of ESD mRNA

NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144

G

estrogen receptor 1

multiple interactions
decreases expression
increases expression
increases methylation
increases activity
affects binding

[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [DDT results in increased activity of ESR1 protein] which results in decreased expression of GABRP mRNA; [DDT results in increased activity of ESR1 protein] which results in decreased expression of GSN mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of BCL2 mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA; [DDT results in increased activity of ESR1 protein] which results in increased expression of TFF1 mRNA; [Hexachlorocyclohexane co-treated with DDT] results in increased expression of ESR1; DDT binds to and results in increased activity of ESR1 protein
DDT results in decreased expression of ESR1 mRNA
DDT results in increased expression of ESR1 mRNA
DDT results in decreased expression of ESR1 protein
DDT results in increased methylation of ESR1 gene
DDT promotes the reaction [ESR1 protein binds to CCND1 promoter]; DDT promotes the reaction [ESR1 protein binds to CDKN1A promoter]
[o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR1 protein
DDT binds to ESR1 protein
DDT results in increased expression of ESR1 mRNA; DDT results in increased expression of ESR1 protein

PMID:9860891 PMID:11485867 PMID:12676605 PMID:15026083 PMID:15064155 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
increases activity

DDT binds to and results in increased activity of ESR2 protein
DDT results in increased activity of ESR2 protein
[o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR2 protein

PMID:9860891 PMID:15064155 PMID:16626760 PMID:26139245 PMID:26812056 More...

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

epithelial splicing regulatory protein 1

increases methylation

DDT results in increased methylation of ESRP1 gene

NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062

G

fatty acid binding protein 4

increases expression

DDT results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

family with sequence similarity 171, member B

decreases expression

DDT results in decreased expression of FAM171B mRNA

NCBI chr 3:68,930,755...68,986,113
Ensembl chr 3:68,930,822...68,986,127

G

family with sequence similarity 174, member A

increases methylation

DDT results in increased methylation of FAM174A gene

NCBI chr 9:95,742,815...95,761,083
Ensembl chr 9:95,742,927...95,761,081

G

family with sequence similarity 50, member A

decreases expression

DDT results in decreased expression of FAM50A mRNA

NCBI chr X:152,095,245...152,102,362
Ensembl chr X:152,095,245...152,102,362

G

FANCD2 and FANCI associated nuclease 1

increases methylation

DDT results in increased methylation of FAN1 gene

NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977

G

fibroblast activation protein, alpha

increases methylation

DDT results in increased methylation of FAP gene

NCBI chr 3:47,138,823...47,207,671
Ensembl chr 3:47,138,813...47,225,545

G

Fas ligand

increases expression

DDT results in increased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

decreases expression

DDT results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

F-box protein 32

decreases expression

DDT results in decreased expression of FBXO32 mRNA

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

FYVE, RhoGEF and PH domain containing 3

increases methylation

DDT results in increased methylation of FGD3 gene

NCBI chr17:15,324,848...15,387,271
Ensembl chr17:15,336,837...15,385,712

G

fibroblast growth factor 2

decreases expression

DDT results in decreased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibrinogen-like 2

decreases expression

DDT results in decreased expression of FGL2 mRNA

NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207

G

filamin A interacting protein 1-like

decreases expression

DDT results in decreased expression of FILIP1L mRNA

NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415

G

fukutin

decreases methylation

DDT results in decreased methylation of FKTN gene

NCBI chr 5:68,339,803...68,396,412
Ensembl chr 5:68,340,028...68,396,409

G

fibronectin 1

increases expression

DDT results in increased expression of FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

folate hydrolase 1

multiple interactions
increases expression

DDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]; DDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 protein]
DDT results in increased expression of FOLH1 protein

NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases activity
increases expression
multiple interactions

DDT results in increased activity of FOS protein
DDT results in increased expression of FOS mRNA
[Permethrin co-treated with DDT co-treated with Diethylstilbestrol] inhibits the reaction [Potassium results in increased expression of FOS mRNA]; DDT inhibits the reaction [Potassium results in increased expression of FOS mRNA]; DDT promotes the reaction [FOS protein binds to CCND1 promoter]; fulvestrant inhibits the reaction [DDT results in increased expression of FOS mRNA]

PMID:14604893 PMID:15527870 PMID:23684557 PMID:25014179 PMID:28263910 More...

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

DDT results in increased expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

increases expression

DDT results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box J3

increases methylation

DDT results in increased methylation of FOXJ3 gene

NCBI chr 5:133,140,344...133,228,489
Ensembl chr 5:133,140,884...133,228,489

G

forkhead box P2

decreases expression

DDT results in decreased expression of FOXP2 mRNA

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

FERM domain containing 3

decreases expression

DDT results in decreased expression of FRMD3 mRNA

NCBI chr 5:87,764,755...88,031,091
Ensembl chr 5:87,764,604...88,031,091

G

FRY like transcription coactivator

increases methylation

DDT results in increased methylation of FRYL gene

NCBI chr14:34,956,623...35,189,738
Ensembl chr14:34,956,620...35,190,222

G

follicle stimulating hormone subunit beta

multiple interactions
increases expression

DDT inhibits the reaction [FSHB protein binds to FSHR protein]
DDT promotes the reaction [[FSHB protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]
DDT results in increased expression of FSHB mRNA; DDT results in increased expression of FSHB protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased expression of FSHB mRNA]

PMID:17157474 PMID:24814263 PMID:26895433

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

follicle stimulating hormone receptor

affects activity
decreases activity
multiple interactions

DDT affects the activity of FSHR protein
DDT results in decreased activity of FSHR protein
DDT promotes the reaction [[CGA protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]; DDT promotes the reaction [[FSHB protein results in increased activity of FSHR protein] which results in increased abundance of Cyclic AMP]
DDT inhibits the reaction [FSHB protein binds to FSHR protein]

PMID:17157474 PMID:26895433

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

glucose-6-phosphate dehydrogenase

increases activity
multiple interactions

DDT results in increased activity of G6PD protein
Inositol inhibits the reaction [DDT results in increased activity of G6PD protein]

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

gamma-aminobutyric acid type B receptor subunit 2

decreases expression

DDT results in decreased expression of GABBR2 mRNA

NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104

G

gamma-aminobutyric acid type A receptor subunit gamma 3

decreases methylation

DDT results in decreased methylation of GABRG3 gene

NCBI chr 1:107,627,450...108,247,483
Ensembl chr 1:107,627,390...108,246,763

G

gamma-aminobutyric acid type A receptor subunit pi

multiple interactions

[DDT results in increased activity of ESR1 protein] which results in decreased expression of GABRP mRNA

NCBI chr10:18,143,031...18,169,595
Ensembl chr10:18,143,038...18,169,516

G

growth arrest and DNA-damage-inducible, beta

multiple interactions
increases expression

Androstanols inhibits the reaction [DDT results in increased expression of GADD45B mRNA]; DDT promotes the reaction [GADD45B protein binds to CYP2B10 promoter]
DDT results in increased expression of GADD45B mRNA; DDT results in increased expression of GADD45B protein

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

galanin and GMAP prepropeptide

decreases expression

DDT results in decreased expression of GAL mRNA

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

growth arrest specific 5

decreases expression

DDT results in decreased expression of GAS5 mRNA

NCBI chr13:73,303,611...73,306,932

G

GRIP and coiled-coil domain containing 2

decreases expression

DDT results in decreased expression of GCC2 mRNA

NCBI chr20:26,247,394...26,293,613
Ensembl chr20:26,247,404...26,293,613

G

glutamate-cysteine ligase, catalytic subunit

increases expression

DDT results in increased expression of GCLC mRNA

PMID:26198647 PMID:29477483

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

DDT results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glucosaminyl (N-acetyl) transferase 4

increases methylation

DDT results in increased methylation of GCNT4 gene

NCBI chr 2:28,253,325...28,283,082
Ensembl chr 2:28,252,860...28,283,082

G

GDNF family receptor alpha 1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA

NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473

G

gamma-glutamyltransferase 1

decreases activity
increases activity

DDT results in decreased activity of GGT1 protein
DDT results in increased activity of GGT1 protein

PMID:2387028 PMID:9475050

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

growth hormone receptor

decreases expression

DDT results in decreased expression of GHR mRNA

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

gap junction protein, alpha 1

multiple interactions
increases expression
increases degradation
decreases expression

[DDT co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GJA1 protein
DDT results in increased expression of GJA1 protein modified form
DDT results in increased degradation of GJA1 protein; DDT results in increased degradation of GJA1 protein modified form
Chloroquine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; DDT results in decreased expression of and results in increased phosphorylation of GJA1 protein
DDT results in decreased expression of GJA1 protein; DDT results in decreased expression of GJA1 protein modified form

PMID:8285856 PMID:8313522 PMID:8820588 PMID:8824497 PMID:15082077 More...

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, beta 1

multiple interactions
decreases expression

[DDT co-treated with Diethylnitrosamine] results in decreased expression of GJB1 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of GJB1 mRNA
DDT results in decreased expression of GJB1 protein

PMID:8242434 PMID:15885732

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

gonadotropin releasing hormone 1

multiple interactions

[Hexachlorocyclohexane co-treated with DDT] results in increased expression of GNRH1

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

golgin B1

decreases expression

DDT results in decreased expression of GOLGB1 mRNA

NCBI chr11:63,843,179...63,900,665
Ensembl chr11:63,843,986...63,900,770

G

golgi integral membrane protein 4

decreases expression

DDT results in decreased expression of GOLIM4 mRNA

NCBI chr 2:160,640,837...160,733,475
Ensembl chr 2:160,640,938...160,733,253

G

glycerol-3-phosphate acyltransferase 3

increases expression

DDT results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

glypican 3

increases expression

DDT results in increased expression of GPC3 mRNA

NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798

G

G protein-coupled estrogen receptor 1

affects binding
affects expression
decreases expression
increases methylation

DDT binds to GPER1 protein
DDT affects the expression of GPER1 mRNA
DDT results in decreased expression of GPER1 protein
DDT results in increased methylation of GPER1 gene

PMID:17088055 PMID:28263910

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

G

glycoprotein nmb

increases methylation

DDT results in increased methylation of GPNMB gene

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

G-protein coupled receptor 88

decreases methylation

DDT results in decreased methylation of GPR88 gene

NCBI chr 2:204,191,443...204,199,576
Ensembl chr 2:204,191,427...204,199,733

G

glutamic--pyruvic transaminase

increases activity

DDT results in increased activity of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

growth factor receptor bound protein 2

multiple interactions

DDT promotes the reaction [GRB2 protein binds to SOS1 protein]

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

galectin-related inter-fiber protein

increases expression

DDT results in increased expression of GRIFIN mRNA

NCBI chr12:14,080,170...14,082,892
Ensembl chr12:14,080,910...14,082,877

G

glutamate metabotropic receptor 1

decreases methylation

DDT results in decreased methylation of GRM1 gene

NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170

G

glutamate metabotropic receptor 8

decreases methylation

DDT results in decreased methylation of GRM8 gene

NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831

G

glycogen synthase kinase 3 beta

increases phosphorylation
multiple interactions

DDT results in increased phosphorylation of GSK3B protein
Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

multiple interactions

[DDT results in increased activity of ESR1 protein] which results in decreased expression of GSN mRNA

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione S-transferase alpha 1

increases expression

DDT results in increased expression of GSTA1 mRNA

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

increases expression

DDT results in increased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase omega 1

increases expression

DDT results in increased expression of GSTO1 mRNA

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

H2A clustered histone 20

decreases expression

DDT results in decreased expression of H2AC20 mRNA

NCBI chr 2:183,779,879...183,780,357

G

HERPUD family member 2

increases methylation

DDT results in increased methylation of HERPUD2 gene

NCBI chr 8:23,573,374...23,618,380
Ensembl chr 8:23,573,379...23,617,874

G

hepatocyte growth factor

decreases expression

DDT results in decreased expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

homeodomain interacting protein kinase 3

increases methylation

DDT results in increased methylation of HIPK3 gene

NCBI chr 3:90,796,980...90,866,701
Ensembl chr 3:90,800,296...90,867,759

G

heme oxygenase 1

increases expression

DDT results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HNF1 homeobox A

multiple interactions

[DDT co-treated with Diethylnitrosamine] results in decreased expression of HNF1A mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of HNF1A mRNA

NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104

G

hook microtubule-tethering protein 3

decreases expression

DDT results in decreased expression of HOOK3 mRNA

NCBI chr16:65,954,293...66,058,812
Ensembl chr16:65,954,350...66,061,338

G

heparan sulfate-glucosamine 3-sulfotransferase 2

decreases methylation

DDT results in decreased methylation of HS3ST2 gene

NCBI chr 1:175,956,161...176,077,400
Ensembl chr 1:175,956,157...176,077,399

G

hydroxysteroid (17-beta) dehydrogenase 1

decreases expression
multiple interactions

DDT results in decreased expression of HSD17B1 mRNA
MT2A protein inhibits the reaction [DDT results in decreased expression of HSD17B1 mRNA]

NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

increases expression

DDT results in increased expression of HSD3B1 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

heat shock protein 90 alpha family class B member 1

decreases expression

DDT results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 4

decreases expression

DDT results in decreased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 5

increases expression

DDT results in increased expression of HSPA5 mRNA

PMID:15710169 PMID:29477483

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

5-hydroxytryptamine receptor 1A

decreases expression

DDT results in decreased expression of HTR1A mRNA

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

integrin-binding sialoprotein

increases methylation

DDT results in increased methylation of IBSP gene

NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693

G

insulin degrading enzyme

decreases activity

DDT results in decreased activity of IDE protein

NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440

G

interferon-induced protein with tetratricopeptide repeats 2

decreases expression

DDT results in decreased expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

interferon induced transmembrane protein 1

decreases expression

DDT results in decreased expression of IFITM1 mRNA

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

G

insulin-like growth factor 1

multiple interactions
decreases expression
increases methylation

DDT affects the reaction [Metribolone results in increased expression of IGF1 mRNA]
DDT results in decreased expression of IGF1 mRNA
DDT results in increased methylation of IGF1 gene

PMID:25682698 PMID:30207508 PMID:30822522

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2

decreases expression

DDT results in decreased expression of IGF2 mRNA

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

interleukin 1 beta

decreases expression
increases secretion
multiple interactions

DDT metabolite results in decreased expression of IL1B mRNA; DDT results in decreased expression of IL1B mRNA
DDT results in increased secretion of IL1B protein
[DDT co-treated with o,p'-DDT] results in decreased expression of IL1B mRNA

PMID:12007859 PMID:27592000

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

increases expression
decreases expression

DDT results in increased expression of IL1R1 mRNA
DDT results in decreased expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 2

decreases expression

DDT results in decreased expression of IL2 mRNA; DDT results in decreased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

multiple interactions

[DDT co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

decreases expression
multiple interactions
increases expression

DDT results in decreased expression of IL6 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of and results in increased secretion of IL6 protein]; DDT results in increased expression of and results in increased secretion of IL6 protein
DDT results in increased expression of IL6 mRNA

PMID:29477483 PMID:31542660

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit beta C

decreases methylation

DDT results in decreased methylation of INHBC gene

NCBI chr 7:63,184,141...63,197,630
Ensembl chr 7:63,184,142...63,197,630

G

insulin 1

decreases secretion

DDT results in decreased secretion of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin receptor

decreases methylation

DDT results in decreased methylation of INSR gene

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

integrin subunit alpha 5

increases expression

DDT results in increased expression of ITGA5 mRNA

NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837

G

integrin subunit alpha 9

increases expression

DDT results in increased expression of ITGA9 mRNA

NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754

G

integrin subunit beta 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]; ruxolitinib inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]; WP1066 inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

iodotyrosine deiodinase

multiple interactions

DDT inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319

G

Janus kinase 1

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]; ruxolitinib inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases activity
increases expression

DDT results in increased activity of JUN protein
DDT results in increased expression of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

DDT results in increased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

potassium voltage-gated channel subfamily H member 2

decreases activity

DDT results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium voltage-gated channel subfamily H member 8

decreases methylation

DDT results in decreased methylation of KCNH8 gene

NCBI chr 9:5,506,044...5,945,828
Ensembl chr 9:5,506,044...5,945,828

G

lysine demethylase 7A

decreases expression

DDT results in decreased expression of KDM7A mRNA

NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998

G

kinesin family member 9

increases methylation

DDT results in increased methylation of KIF9 gene

NCBI chr 8:110,459,467...110,504,492
Ensembl chr 8:110,459,383...110,505,252

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

KLF transcription factor 4

decreases expression

DDT results in decreased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kallikrein related-peptidase 13

increases methylation

DDT results in increased methylation of KLK13 gene

NCBI chr 1:94,165,381...94,177,002
Ensembl chr 1:94,165,381...94,177,002

G

kallikrein 1-related peptidase C10

decreases expression
multiple interactions

DDT results in decreased expression of KLK3 mRNA
DDT inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]; DDT inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; DDT inhibits the reaction [Metribolone results in increased expression of KLK3 protein]

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

keratin 18

decreases expression

DDT results in decreased expression of KRT18 protein

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166

G

keratin 34

decreases expression

DDT results in decreased expression of KRT34 mRNA

NCBI chr10:84,969,988...84,974,098
Ensembl chr10:84,970,017...84,974,040

G

keratin 8

decreases expression

DDT results in decreased expression of KRT8 protein

NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728

G

keratin associated protein 16-1

increases methylation

DDT results in increased methylation of KRTAP16-1 gene

NCBI chr10:84,915,116...84,916,984
Ensembl chr10:84,915,488...84,916,969

G

kinectin 1

increases expression

DDT results in increased expression of KTN1 mRNA

NCBI chr15:20,913,665...21,002,588
Ensembl chr15:20,914,642...21,002,578

G

LBH regulator of WNT signaling pathway

increases expression

DDT results in increased expression of LBH mRNA

NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079

G

lactate dehydrogenase A

increases expression
multiple interactions

DDT results in increased expression of LDHA mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of LDHA mRNA]; Acetylcysteine inhibits the reaction [DDT results in increased expression of LDHA mRNA]; PKM protein alternative form affects the reaction [DDT results in increased expression of LDHA mRNA]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

leptin

increases expression

DDT results in increased expression of LEP mRNA

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leucine-rich repeat LGI family, member 2

decreases methylation

DDT results in decreased methylation of LGI2 gene

NCBI chr14:58,415,965...58,443,450
Ensembl chr14:58,415,965...58,443,407

G

luteinizing hormone subunit beta

multiple interactions
increases expression

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased expression of LHB mRNA]
DDT inhibits the reaction [LHB protein results in increased abundance of Cyclic AMP]; DDT inhibits the reaction [LHB protein results in increased secretion of Progesterone]
DDT results in increased expression of LHB protein

PMID:24814263 PMID:33638691

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

LIF, interleukin 6 family cytokine

increases expression

DDT results in increased expression of LIF mRNA

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

LMBR1 domain containing 2

decreases expression

DDT results in decreased expression of LMBRD2 mRNA

NCBI chr 2:58,189,558...58,251,565
Ensembl chr 2:58,189,558...58,247,076

G

leucyl and cystinyl aminopeptidase

decreases expression

DDT results in decreased expression of LNPEP mRNA

NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544

G

hypothetical protein LOC100362109

decreases expression

DDT results in decreased expression of C22ORF46P mRNA

NCBI chr 7:113,578,871...113,586,264
Ensembl chr 7:113,578,739...113,586,266

G

small nucleolar RNA SNORA5

decreases expression

DDT results in decreased expression of SNORA5A mRNA

NCBI chr14:81,486,718...81,486,846
Ensembl chr14:81,486,718...81,486,846

G

small nucleolar RNA SNORD126

decreases expression

DDT results in decreased expression of SNORD126 mRNA

NCBI chr15:24,025,336...24,025,412
Ensembl chr15:24,025,336...24,025,412

G

small nucleolar RNA SNORA42/SNORA80 family

decreases expression

DDT results in decreased expression of SNORA80A mRNA

NCBI chr18:60,563,049...60,563,183
Ensembl chr18:60,563,049...60,563,183

G

5S ribosomal RNA

increases methylation

DDT results in increased methylation of RN5S gene

NCBI chr19:51,610,075...51,610,193
Ensembl chr19:51,610,075...51,610,193
Ensembl chr19:51,610,075...51,610,193
Ensembl chr19:51,610,075...51,610,193
Ensembl chr19:51,610,075...51,610,193
Ensembl chr19:51,610,075...51,610,193
Ensembl chr19:51,610,075...51,610,193
Ensembl chr19:51,610,075...51,610,193

G

small nucleolar RNA SNORA55

decreases expression

DDT results in decreased expression of SNORA55 mRNA

NCBI chr 5:135,573,359...135,573,491
Ensembl chr 5:135,573,359...135,573,491

G

lysyl oxidase

decreases expression

DDT results in decreased expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

lipoxygenase homology PLAT domains 1

increases methylation

DDT results in increased methylation of LOXHD1 gene

NCBI chr18:70,817,962...70,970,606
Ensembl chr18:70,818,276...70,969,983

G

lipoprotein lipase

increases expression

DDT results in increased expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

LIM domain containing preferred translocation partner in lipoma

decreases expression
decreases methylation

DDT results in decreased expression of LPP mRNA
DDT results in decreased methylation of LPP gene

PMID:30207508 PMID:31682807

NCBI chr11:75,787,326...76,426,646
Ensembl chr11:75,797,078...76,422,597

G

LRAT domain containing 2

decreases methylation

DDT results in decreased methylation of LRATD2 gene

NCBI chr 7:92,376,713...92,387,045
Ensembl chr 7:92,362,194...92,388,189

G

leucine rich repeat containing 2

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA

NCBI chr 8:110,936,119...110,969,189
Ensembl chr 8:110,938,165...110,969,185

G

LRR binding FLII interacting protein 1

decreases expression

DDT results in decreased expression of LRRFIP1 mRNA

NCBI chr 9:91,592,032...91,720,250
Ensembl chr 9:91,643,197...91,720,250

G

lactotransferrin

increases expression

DDT results in increased expression of LTF mRNA

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

lumican

increases expression

DDT results in increased expression of LUM mRNA

NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793

G

leucine zipper protein 2

decreases methylation

DDT results in decreased methylation of LUZP2 gene

NCBI chr 1:105,597,291...105,983,605
Ensembl chr 1:105,597,307...105,981,183

G

lymphocyte antigen 86

increases methylation

DDT results in increased methylation of LY86 gene

NCBI chr17:27,415,807...27,499,695
Ensembl chr17:27,415,830...27,487,260

G

lymphocyte antigen 9

increases methylation

DDT results in increased methylation of LY9 gene

NCBI chr13:84,079,345...84,100,783
Ensembl chr13:84,079,458...84,100,823

G

LYN proto-oncogene, Src family tyrosine kinase

decreases methylation

DDT results in decreased methylation of LYN gene

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

meiosis 1 associated protein

increases methylation

DDT results in increased methylation of M1AP gene

NCBI chr 4:115,445,910...115,536,745
Ensembl chr 4:115,455,397...115,536,487

G

mab-21 like 1

decreases expression

DDT results in decreased expression of MAB21L1 mRNA

NCBI chr 2:139,943,496...139,945,885
Ensembl chr 2:139,943,496...139,945,885

G

MAGE family member B1

increases methylation

DDT results in increased methylation of MAGEB4 gene

NCBI chr X:50,915,789...50,921,863

G

mannosidase beta

increases methylation

DDT results in increased methylation of MANBA gene

NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983

G

mannosidase, endo-alpha

decreases expression

DDT results in decreased expression of MANEA mRNA

NCBI chr 5:40,196,373...40,218,540
Ensembl chr 5:40,196,396...40,218,459

G

microtubule-associated protein 2

decreases expression

DDT results in decreased expression of MAP2 mRNA

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen-activated protein kinase kinase 6

multiple interactions

MAP2K6 protein promotes the reaction [DDT results in increased activity of NOTCH1 protein]

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions
increases activity

DDT results in increased phosphorylation of MAPK1 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of MAPK1 protein]; DDT results in increased phosphorylation of and results in increased activity of MAPK1 protein
DDT results in increased activity of MAPK1 protein

PMID:9070211 PMID:12523960 PMID:14604893 PMID:24814263 PMID:31724279

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

increases phosphorylation

DDT results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

DDT results in increased phosphorylation of MAPK3 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [DDT results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of MAPK3 protein]; DDT results in increased phosphorylation of and results in increased activity of MAPK3 protein

PMID:9070211 PMID:14604893 PMID:24814263 PMID:31724279

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

decreases phosphorylation

DDT results in decreased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 8 interacting protein 3

increases expression

DDT results in increased expression of MAPK8IP3 mRNA

NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273

G

mitogen-activated protein kinase 9

decreases phosphorylation

DDT results in decreased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

matrin 3

decreases expression

DDT results in decreased expression of MATR3 mRNA

NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166

G

minichromosome maintenance complex component 4

decreases expression

DDT results in decreased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

mitochondrial calcium uniporter regulator 1

increases methylation

DDT results in increased methylation of MCUR1 gene

NCBI chr17:21,142,526...21,159,651
Ensembl chr17:21,141,602...21,159,651

G

MDM2 proto-oncogene

multiple interactions
increases expression

Androstanols inhibits the reaction [DDT results in increased expression of MDM2 mRNA]
DDT results in increased expression of MDM2 mRNA; DDT results in increased expression of MDM2 protein

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

maternally expressed 3

increases expression

DDT results in increased expression of MEG3 mRNA

NCBI chr 6:128,491,808...128,524,010

G

matrix extracellular phosphoglycoprotein

increases methylation

DDT results in increased methylation of MEPE gene

NCBI chr14:5,420,634...5,432,186
Ensembl chr14:5,420,635...5,432,183

G

MER proto-oncogene, tyrosine kinase

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA

NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554

G

MET proto-oncogene, receptor tyrosine kinase

increases phosphorylation

DDT results in increased phosphorylation of MET protein

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

microfibril associated protein 3 like

decreases expression

DDT results in decreased expression of MFAP3L mRNA

NCBI chr16:29,411,643...29,454,665
Ensembl chr16:29,415,849...29,430,863

G

matrix Gla protein

increases expression

DDT results in increased expression of MGP mRNA

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

G

microRNA 15b

decreases expression

DDT results in decreased expression of MIR15B mRNA

NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297

G

microRNA 190

increases expression

DDT results in increased expression of MIR190 mRNA

NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071

G

microRNA 190b

increases expression

DDT results in increased expression of MIR190B mRNA

NCBI chr 2:175,514,800...175,514,877
Ensembl chr 2:175,514,800...175,514,877

G

microRNA 193a

increases expression

DDT results in increased expression of MIR193A mRNA

NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454

G

microRNA 202

increases expression

DDT results in increased expression of MIR202 mRNA

NCBI chr 1:194,754,730...194,754,801
Ensembl chr 1:194,754,730...194,754,801

G

microRNA 21

decreases expression
increases expression

DDT results in decreased expression of MIR21 mRNA
DDT results in increased expression of MIR21 mRNA

PMID:22403704 PMID:32508177

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 23a

increases methylation

DDT results in increased methylation of MIR23A gene

NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071

G

microRNA 24-2

increases methylation

DDT results in increased methylation of MIR24-2 gene

NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790

G

microRNA 27a

increases methylation

DDT results in increased methylation of MIR27A gene

NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917

G

microRNA 27b

decreases expression

DDT results in decreased expression of MIR27B mRNA

NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529

G

microRNA 342

decreases expression

DDT results in decreased expression of MIR342 mRNA

NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367

G

microRNA 34b

decreases expression

DDT results in decreased expression of MIR34B mRNA

NCBI chr 8:51,410,244...51,410,327
Ensembl chr 8:51,410,244...51,410,327

G

microRNA 34c

decreases expression

DDT results in decreased expression of MIR34C mRNA

NCBI chr 8:51,409,726...51,409,802
Ensembl chr 8:51,409,726...51,409,802

G

microRNA 374b

increases expression

DDT results in increased expression of MIR374 mRNA

NCBI chr X:68,591,732...68,591,799
Ensembl chr X:68,591,732...68,591,799

G

microRNA 484

decreases methylation

DDT results in decreased methylation of MIR484 gene

NCBI chr10:887,684...887,760
Ensembl chr10:887,684...887,760

G

microRNA 6333

increases methylation

DDT results in increased methylation of MIR6333 gene

NCBI chr 5:147,725,453...147,725,563
Ensembl chr 5:147,725,453...147,725,563

G

microRNA 92b

decreases expression

DDT results in decreased expression of MIR92B mRNA

NCBI chr 2:174,633,890...174,633,972
Ensembl chr 2:174,633,890...174,633,972

G

microRNA 99b

decreases expression

DDT results in decreased expression of MIR99B mRNA

NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090

G

microRNA let-7b

decreases expression

DDT results in decreased expression of MIRLET7B mRNA

NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270

G

melanocyte inducing transcription factor

increases methylation

DDT results in increased methylation of MITF gene

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

metabolism of cobalamin associated D

increases methylation

DDT results in increased methylation of MMADHC gene

NCBI chr 3:34,708,649...34,726,554
Ensembl chr 3:34,708,649...34,726,771

G

membrane metallo-endopeptidase

decreases expression
increases expression

DDT results in decreased expression of MME mRNA
DDT results in increased expression of MME mRNA

PMID:30207508 PMID:35946953

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 2

increases expression

DDT results in increased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

multiple interactions
increases expression

13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [DDT results in increased expression of MMP3 mRNA]; zerumbone inhibits the reaction [DDT results in increased expression of MMP3 mRNA]

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

mannosyl-oligosaccharide glucosidase

decreases expression

DDT results in decreased expression of MOGS mRNA

NCBI chr 4:115,621,623...115,625,026
Ensembl chr 4:115,621,623...115,625,032

G

methionine sulfoxide reductase A

decreases methylation

DDT results in decreased methylation of MSRA gene

NCBI chr15:38,363,459...38,677,406
Ensembl chr15:38,351,445...38,676,585

G

msh homeobox 1

decreases expression

DDT results in decreased expression of MSX1 mRNA

NCBI chr14:72,961,036...72,964,970
Ensembl chr14:72,961,148...72,964,966

G

metallothionein 2A

multiple interactions
decreases expression

MT2A protein inhibits the reaction [DDT results in decreased expression of HSD17B1 mRNA]
DDT results in decreased expression of MT2A mRNA

PMID:12858341 PMID:25014179

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

Mtr4 exosome RNA helicase

decreases methylation

DDT results in decreased methylation of MTREX gene

NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627

G

mucin 6, oligomeric mucus/gel-forming

increases methylation

DDT results in increased methylation of MUC6 gene

NCBI chr 1:196,726,678...196,764,842
Ensembl chr 1:196,726,807...196,764,842

G

MAX interactor 1, dimerization protein

decreases methylation

DDT results in decreased methylation of MXI1 gene

NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression

[EGF protein co-treated with DDT] results in increased expression of MYC mRNA
DDT results in increased expression of MYC protein
fulvestrant inhibits the reaction [DDT results in increased expression of MYC mRNA]
DDT results in increased expression of MYC mRNA; DDT results in increased expression of MYC protein

PMID:12632255 PMID:23684557 PMID:24968063

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin heavy chain 11

increases expression

DDT results in increased expression of MYH11 mRNA

NCBI chr10:743,364...838,459
Ensembl chr10:743,685...838,459

G

neuron navigator 1

increases methylation

DDT results in increased methylation of NAV1 gene

NCBI chr13:46,866,972...47,119,368
Ensembl chr13:46,873,689...47,126,449

G

nuclear receptor coactivator 2

decreases methylation

DDT results in decreased methylation of NCOA2 gene

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

nudE neurodevelopment protein 1

decreases methylation

DDT results in decreased methylation of NDE1 gene

NCBI chr10:839,788...883,946
Ensembl chr10:839,788...883,869

G

NFE2 like bZIP transcription factor 2

increases expression

DDT results in increased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

decreases expression

DDT results in decreased expression of NFKB1 protein

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFS1 cysteine desulfurase

decreases methylation

DDT results in decreased methylation of NFS1 gene

NCBI chr 3:144,637,309...144,659,660
Ensembl chr 3:144,637,309...144,659,666

G

NHS-like 2

increases methylation

DDT results in increased methylation of NHSL2 gene

NCBI chr X:66,969,953...67,209,464
Ensembl chr X:66,970,151...67,200,911

G

nidogen 1

increases expression

DDT results in increased expression of NID1 mRNA

NCBI chr17:86,085,133...86,158,272
Ensembl chr17:86,085,077...86,158,267

G

NIPA-like domain containing 3

increases methylation

DDT results in increased methylation of NIPAL3 gene

NCBI chr 5:147,687,310...147,725,838
Ensembl chr 5:147,685,288...147,726,351

G

NLR family, CARD domain containing 5

increases methylation

DDT results in increased methylation of NLRC5 gene

NCBI chr19:10,477,638...10,581,023
Ensembl chr19:10,477,628...10,562,121

G

NLR family, pyrin domain containing 5

decreases expression

DDT results in decreased expression of NLRP5 mRNA

NCBI chr 1:67,778,037...67,810,941
Ensembl chr 1:67,777,948...68,023,736

G

nitric oxide synthase 2

decreases expression
multiple interactions
increases expression

DDT results in decreased expression of NOS2 mRNA
[DDT co-treated with o,p'-DDT] results in decreased expression of NOS2 mRNA
DDT results in increased expression of NOS2 mRNA
DDT metabolite results in decreased expression of NOS2 mRNA; DDT results in decreased expression of NOS2 mRNA

PMID:11948501 PMID:12007859

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

increases activity
multiple interactions

DDT results in increased activity of NOTCH1 protein
MAP2K6 protein promotes the reaction [DDT results in increased activity of NOTCH1 protein]

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

defensin NP-4 precursor

increases methylation

DDT results in increased methylation of NP4 gene

NCBI chr16:70,494,607...70,497,261
Ensembl chr16:70,342,529...70,497,202

G

NAD(P)H quinone dehydrogenase 1

increases expression

DDT results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group H, member 3

decreases expression
multiple interactions

DDT results in decreased expression of NR1H3 mRNA; DDT results in decreased expression of NR1H3 protein
DDT inhibits the reaction [T0901317 results in increased expression of NR1H3 protein]

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

[DDT co-treated with Dieldrin] results in increased activity of NR1I2 protein; DDT binds to and results in increased activity of NR1I2 protein
DDT results in increased activity of NR1I2 protein

PMID:15548381 PMID:16054614 PMID:20686338 PMID:25028461 PMID:25680588 More...

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases expression
increases activity
multiple interactions

DDT results in increased expression of NR1I3 mRNA
DDT results in increased activity of NR1I3 protein
DDT inhibits the reaction [Androstenols results in decreased activity of NR1I3 protein]; DDT promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]
DDT binds to and results in increased activity of and results in increased localization of NR1I3 protein mutant form

PMID:16929008 PMID:19746742 PMID:20686338 PMID:23684557 PMID:28927721

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

DDT inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions

DDT inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; DDT inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

neurexin 1

increases methylation

DDT results in increased methylation of NRXN1 gene

NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710

G

neurexin 3

increases methylation

DDT results in increased methylation of NRXN3 gene

NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044

G

netrin 1

increases methylation

DDT results in increased methylation of NTN1 gene

NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326

G

netrin 4

decreases expression

DDT results in decreased expression of NTN4 mRNA

NCBI chr 7:28,186,611...28,300,390
Ensembl chr 7:28,186,611...28,300,390

G

neurotrophic receptor tyrosine kinase 1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

nuclear VCP-like

increases methylation

DDT results in increased methylation of NVL gene

NCBI chr13:92,851,023...92,906,749
Ensembl chr13:92,853,650...92,906,049

G

2-oxoglutarate and iron-dependent oxygenase domain containing 3

increases methylation

DDT results in increased methylation of OGFOD3 gene

NCBI chr10:106,452,334...106,480,632
Ensembl chr10:106,452,329...106,480,134

G

8-oxoguanine DNA glycosylase

multiple interactions
increases expression

[DDT co-treated with Diethylnitrosamine] results in decreased expression of OGG1 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of OGG1 mRNA
DDT results in increased expression of OGG1 mRNA

PMID:11948501 PMID:15885732

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

O-linked N-acetylglucosamine (GlcNAc) transferase

increases expression
increases methylation

DDT results in increased expression of OGT mRNA
DDT results in increased methylation of OGT gene

PMID:25014179 PMID:30207508

NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146

G

oligophrenin 1

decreases methylation

DDT results in decreased methylation of OPHN1 gene

NCBI chr X:63,599,746...63,976,678
Ensembl chr X:63,603,042...63,976,633

G

olfactory receptor family 10 subfamily AK member 7F

increases methylation

DDT results in increased methylation of OR10AK7F gene

NCBI chr 5:132,407,421...132,408,368
Ensembl chr 5:132,407,421...132,408,368
Ensembl chr 5:132,407,421...132,408,368

G

olfactory receptor family 10 subfamily AL member 27

decreases methylation

DDT results in decreased methylation of OR10AL27 gene

NCBI chr20:789,272...790,237
Ensembl chr20:761,025...765,744
Ensembl chr20:761,025...765,744

G

olfactory receptor family 10 subfamily AL member 6

decreases methylation

DDT results in decreased methylation of OR10AL6 gene

NCBI chr20:738,257...739,607
Ensembl chr20:734,965...811,125

G

olfactory receptor family 10 subfamily AP member 2, pseudogene 1

increases methylation

DDT results in increased methylation of OR10AP2-PS1 gene

G

olfactory receptor family 2 subfamily AK member 5F

increases methylation

DDT results in increased methylation of OR2AK5F gene

NCBI chr10:43,269,046...43,269,960
Ensembl chr10:43,289,142...43,290,062

G

olfactory receptor family 7 subfamily G member 23C

decreases methylation

DDT results in decreased methylation of OR7G23C gene

NCBI chr 8:16,808,409...16,809,347
Ensembl chr 8:16,808,409...16,809,347

G

peptidase domain containing associated with muscle regeneration 1

decreases expression

DDT results in decreased expression of PAMR1 mRNA

NCBI chr 3:88,889,061...88,988,615
Ensembl chr 3:88,889,046...88,988,606

G

par-3 family cell polarity regulator

increases methylation

DDT results in increased methylation of PARD3 gene

NCBI chr19:55,080,282...55,630,111
Ensembl chr19:55,080,282...55,629,778

G

paired box 6

multiple interactions

DDT inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA]

NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014

G

protocadherin 20

decreases expression

DDT results in decreased expression of PCDH20 mRNA

NCBI chr15:64,425,534...64,431,790
Ensembl chr15:64,425,534...64,431,790

G

protocadherin 9

decreases expression

DDT results in decreased expression of PCDH9 mRNA

NCBI chr15:69,340,108...70,237,531
Ensembl chr15:69,340,645...70,237,538

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

DDT inhibits the reaction [Hydrocortisone results in increased expression of PCK1 mRNA]

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

piccolo (presynaptic cytomatrix protein)

decreases expression

DDT results in decreased expression of PCLO mRNA

NCBI chr 4:19,691,439...20,050,015
Ensembl chr 4:19,695,315...20,049,885

G

proprotein convertase subtilisin/kexin type 6

increases methylation

DDT results in increased methylation of PCSK6 gene

NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596

G

programmed cell death 4

increases expression

DDT results in increased expression of PDCD4 mRNA

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

phosphodiesterase 7B

decreases expression

DDT results in decreased expression of PDE7B mRNA

NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900

G

platelet derived growth factor receptor alpha

increases expression

DDT results in increased expression of PDGFRA mRNA

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

platelet derived growth factor receptor beta

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

pyruvate dehydrogenase kinase 1

increases expression
multiple interactions

DDT results in increased expression of PDK1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of PDK1 mRNA]; Acetylcysteine inhibits the reaction [DDT results in increased expression of PDK1 mRNA]; PKM protein alternative form affects the reaction [DDT results in increased expression of PDK1 mRNA]

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

PDZ and LIM domain 3

decreases expression

DDT results in decreased expression of PDLIM3 mRNA

NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657

G

proenkephalin

decreases expression

DDT results in decreased expression of PENK mRNA

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

placental growth factor

decreases methylation

DDT results in decreased methylation of PGF gene

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

progesterone receptor

affects binding
decreases expression
increases expression
multiple interactions

DDT binds to PGR protein
DDT results in decreased expression of PGR mRNA
DDT results in increased expression of PGR mRNA
[DDT results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; DDT inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; DDT inhibits the reaction [Progesterone binds to PGR protein]; DDT inhibits the reaction [Progesterone results in increased expression of PGR protein]

PMID:9607801 PMID:14579009 PMID:15541753 PMID:18262749 PMID:22403704 More...

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phosphate regulating endopeptidase X-linked

decreases expression

DDT results in decreased expression of PHEX mRNA

NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469

G

PHD finger protein 3

decreases methylation

DDT results in decreased methylation of PHF3 gene

NCBI chr 9:33,063,855...33,136,013
Ensembl chr 9:33,063,857...33,135,994

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

decreases expression

DDT results in decreased expression of PIK3C2A mRNA

NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472

G

PKHD1 like 1

increases methylation

DDT results in increased methylation of PKHD1L1 gene

NCBI chr 7:75,620,384...75,795,335
Ensembl chr 7:75,620,484...75,795,335

G

pyruvate kinase M1/2

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of and affects the localization of PKM protein alternative form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of PKM mRNA alternative form]; Acetylcysteine inhibits the reaction [DDT results in increased expression of and affects the localization of PKM protein alternative form]; Acetylcysteine inhibits the reaction [DDT results in increased expression of PKM mRNA alternative form]; DDT results in increased expression of and affects the localization of PKM protein alternative form; PKM protein alternative form affects the reaction [DDT results in increased expression of LDHA mRNA]; PKM protein alternative form affects the reaction [DDT results in increased expression of PDK1 mRNA]; PKM protein alternative form affects the reaction [DDT results in increased expression of SLC2A1 mRNA]

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

plakophilin 4

increases methylation

DDT results in increased methylation of PKP4 gene

NCBI chr 3:43,632,364...43,835,834
Ensembl chr 3:43,631,880...43,835,474

G

plasminogen activator, tissue type

decreases expression

DDT results in decreased expression of PLAT mRNA

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

phospholipase D family, member 4

increases methylation

DDT results in increased methylation of PLD4 gene

NCBI chr 6:131,818,860...131,827,457
Ensembl chr 6:131,818,860...131,826,376

G

plastin 3

decreases expression

DDT results in decreased expression of PLS3 mRNA

NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891

G

plexin domain containing 2

decreases expression

DDT results in decreased expression of PLXDC2 mRNA

NCBI chr17:79,169,238...79,594,279
Ensembl chr17:79,196,369...79,585,282

G

plexin D1

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA

NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244

G

patatin-like phospholipase domain containing 8

decreases expression

DDT results in decreased expression of PNPLA8 mRNA

NCBI chr 6:61,329,810...61,391,736
Ensembl chr 6:61,329,810...61,391,734

G

podocalyxin-like

decreases expression

DDT results in decreased expression of PODXL mRNA

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

DNA polymerase theta

decreases methylation

DDT results in decreased methylation of POLQ gene

NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878

G

proopiomelanocortin

multiple interactions

[Hexachlorocyclohexane co-treated with DDT] results in increased expression of POMC

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

POTE ankyrin domain family member M

increases methylation

DDT results in increased methylation of POTEM gene

NCBI chr16:20,193,646...20,311,924
Ensembl chr16:19,949,230...19,976,541

G

POU class 5 homeobox 1

multiple interactions

DDT inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of POU5F1 mRNA]

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

DDT binds to and results in increased activity of PPARG protein; DDT results in increased activity of and results in increased localization of PPARG protein
DDT results in increased expression of PPARG mRNA

PMID:11911853 PMID:25014179 PMID:33049310

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions

DDT promotes the reaction [PPARGC1A protein binds to CYP2B10 promoter]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein phosphatase 2, regulatory subunit B, beta

increases methylation

DDT results in increased methylation of PPP2R2B gene

PMID:30207508 PMID:31682807

NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

decreases expression

DDT results in decreased expression of PREX2 mRNA

NCBI chr 5:7,937,692...8,253,112
Ensembl chr 5:7,942,573...8,253,068

G

protein kinase AMP-activated catalytic subunit alpha 2

decreases expression

DDT results in decreased expression of PRKAA2 mRNA

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

protein kinase AMP-activated non-catalytic subunit gamma 2

decreases methylation

DDT results in decreased methylation of PRKAG2 gene

NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142

G

protein kinase D1

decreases methylation

DDT results in decreased methylation of PRKD1 gene

NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042

G

prolactin receptor

affects expression

DDT affects the expression of PRLR mRNA

NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718

G

protein S

decreases expression

DDT results in decreased expression of PROS1 mRNA

NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286

G

presenilin 1

increases expression

DDT results in increased expression of PSEN1 mRNA

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

G

prostaglandin-endoperoxide synthase 1

decreases expression

DDT results in decreased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; zerumbone inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, receptor type, M

decreases methylation

DDT results in decreased methylation of PTPRM gene

NCBI chr 9:106,639,573...107,343,698
Ensembl chr 9:106,639,573...107,343,698

G

glutamine and serine rich 1

decreases expression

DDT results in decreased expression of QSER1 mRNA

NCBI chr 3:91,137,516...91,202,426
Ensembl chr 3:91,140,967...91,202,052

G

RAB4B, member RAS oncogene family

increases methylation

DDT results in increased methylation of RAB4B gene

NCBI chr 1:82,461,396...82,472,784
Ensembl chr 1:82,461,396...82,472,763

G

Rab geranylgeranyltransferase subunit beta

increases expression

DDT results in increased expression of RABGGTB mRNA

NCBI chr 2:242,844,758...242,850,951
Ensembl chr 2:242,844,762...242,851,050

G

receptor for activated C kinase 1

decreases expression

DDT results in decreased expression of RACK1 mRNA; DDT results in decreased expression of RACK1 protein

NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975

G

RAN binding protein 2

decreases expression

DDT results in decreased expression of RANBP2 mRNA

NCBI chr20:26,442,156...26,493,481
Ensembl chr20:26,442,217...26,493,481

G

RAS and EF hand domain containing

decreases expression

DDT results in decreased expression of RASEF mRNA

NCBI chr 5:87,548,908...87,619,286
Ensembl chr 5:87,548,908...87,619,031

G

RB transcriptional corepressor 1

increases phosphorylation

DDT results in increased phosphorylation of RB1 protein

PMID:9049186 PMID:23684557

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RB1-inducible coiled-coil 1

decreases expression

DDT results in decreased expression of RB1CC1 mRNA

NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560

G

regulator of calcineurin 2

decreases expression

DDT results in decreased expression of RCAN2 mRNA

NCBI chr 9:16,959,478...17,174,823
Ensembl chr 9:16,959,480...17,174,856

G

reticulocalbin 2

decreases expression

DDT results in decreased expression of RCN2 mRNA

NCBI chr 8:56,449,206...56,466,253
Ensembl chr 8:56,449,206...56,466,251

G

ret proto-oncogene

multiple interactions

[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA

NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176

G

raftlin lipid raft linker 1

decreases methylation

DDT results in decreased methylation of RFTN1 gene

NCBI chr 9:10,804,611...11,002,084
Ensembl chr 9:10,804,611...11,002,084

G

receptor-interacting serine-threonine kinase 4

increases methylation

DDT results in increased methylation of RIPK4 gene

NCBI chr11:37,122,555...37,144,799
Ensembl chr11:37,122,565...37,144,799

G

RLF zinc finger

decreases expression

DDT results in decreased expression of RLF mRNA

NCBI chr 5:134,711,612...134,767,274
Ensembl chr 5:134,711,619...134,767,257

G

ring finger protein 150

increases methylation

DDT results in increased methylation of RNF150 gene

NCBI chr19:25,006,978...25,229,273
Ensembl chr19:25,006,611...25,228,678

G

ring finger protein 152

increases methylation

DDT results in increased methylation of RNF152 gene

NCBI chr13:21,324,039...21,403,405
Ensembl chr13:21,323,824...21,403,113

G

ring finger protein 181

decreases expression

DDT results in decreased expression of RNF181 mRNA

NCBI chr 4:104,414,586...104,421,433
Ensembl chr 4:104,414,605...104,421,309

G

Rho-associated coiled-coil containing protein kinase 2

decreases expression

DDT results in decreased expression of ROCK2 mRNA

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

ROS proto-oncogene 1 , receptor tyrosine kinase

decreases methylation

DDT results in decreased methylation of ROS1 gene

NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865

G

ribosomal protein L4

increases expression

DDT results in increased expression of RPL4 mRNA

NCBI chr 8:64,671,177...64,676,301
Ensembl chr 8:64,671,160...64,676,306

G

ribosomal protein S27a

increases methylation

DDT results in increased methylation of RPS27A gene

NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011

G

ribosomal protein S6 kinase C1

increases methylation

DDT results in increased methylation of RPS6KC1 gene

NCBI chr13:102,346,160...102,491,000
Ensembl chr13:102,346,160...102,490,303

G

radical S-adenosyl methionine domain containing 2

decreases expression

DDT results in decreased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

remodeling and spacing factor 1

decreases expression

DDT results in decreased expression of RSF1 mRNA

NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051

G

RT1 class II, locus Ba

decreases methylation

DDT results in decreased methylation of RT1-BA gene

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Bb

decreases methylation

DDT results in decreased methylation of RT1-BB gene

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RUNX family transcription factor 2

increases expression

DDT results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

retinoid X receptor beta

increases activity

DDT analog results in increased activity of RXRB protein

NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773

G

ryanodine receptor 1

affects activity

DDT affects the activity of RYR1 protein

NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812

G

sphingosine-1-phosphate receptor 1

decreases expression

DDT results in decreased expression of S1PR1 mRNA

NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681

G

sacsin molecular chaperone

decreases expression

DDT results in decreased expression of SACS mRNA

NCBI chr15:35,285,783...35,370,335
Ensembl chr15:35,285,782...35,370,335

G

SAP domain containing ribonucleoprotein

decreases expression

DDT results in decreased expression of SARNP mRNA

NCBI chr 7:1,251,096...1,305,335
Ensembl chr 7:1,251,098...1,305,332

G

scavenger receptor class B, member 1

increases expression

DDT results in increased expression of SCARB1 mRNA

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

selenoprotein P

increases expression

DDT results in increased expression of SELENOP mRNA

NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852

G

ssemaphorin 4F

increases methylation

DDT results in increased methylation of SEMA4F gene

NCBI chr 4:115,411,411...115,437,721
Ensembl chr 4:115,411,417...115,437,721

G

semaphorin 5A

decreases expression

DDT results in decreased expression of SEMA5A mRNA

NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084

G

Sumo1/sentrin/SMT3 specific peptidase 17

decreases methylation

DDT results in decreased methylation of SENP17 gene

NCBI chr 4:161,126,901...161,128,328
Ensembl chr 4:161,126,901...161,128,328
Ensembl chr 4:161,126,901...161,128,328

G

serpin family B member 5

multiple interactions

[DDT results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA

NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756

G

sestrin 3

decreases expression

DDT results in decreased expression of SESN3 mRNA

NCBI chr 8:11,133,822...11,189,436
Ensembl chr 8:11,133,678...11,185,842

G

SET domain containing 2, histone lysine methyltransferase

decreases expression

DDT results in decreased expression of SETD2 mRNA

NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489

G

senataxin

decreases expression

DDT results in decreased expression of SETX mRNA

NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803

G

SH3GL interacting endocytic adaptor 1

increases methylation

DDT results in increased methylation of SGIP1 gene

NCBI chr 5:117,536,752...117,734,593
Ensembl chr 5:117,537,746...117,734,575

G

sex hormone binding globulin

multiple interactions

DDT analog inhibits the reaction [Dihydrotestosterone binds to SHBG protein]; DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

SHC adaptor protein 4

increases methylation

DDT results in increased methylation of SHC4 gene

NCBI chr 3:112,880,598...112,974,216
Ensembl chr 3:112,880,600...112,974,366

G

SHC binding and spindle associated 1

decreases expression

DDT results in decreased expression of SHCBP1 mRNA

NCBI chr16:84,672,277...84,703,843
Ensembl chr16:84,672,321...84,703,844

G

solute carrier family 10 member 1

decreases expression

DDT results in decreased expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 12 member 2

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of SLC12A2 mRNA

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 18 member A2

multiple interactions

DDT inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 2 member 1

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [DDT results in increased expression of SLC2A1 mRNA]; Acetylcysteine inhibits the reaction [DDT results in increased expression of SLC2A1 mRNA]; PKM protein alternative form affects the reaction [DDT results in increased expression of SLC2A1 mRNA]

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 4

increases expression
decreases expression

DDT results in increased expression of SLC2A4 mRNA
DDT results in decreased expression of SLC2A4 protein

PMID:25014179 PMID:31923579

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 35, member D3

decreases methylation

DDT results in decreased methylation of SLC35D3 gene

NCBI chr 1:14,565,482...14,573,581
Ensembl chr 1:14,569,687...14,573,159

G

solute carrier family 6 member 3

multiple interactions

DDT inhibits the reaction [DAT protein results in increased uptake of Dopamine]

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 7 member 11

increases expression

DDT results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier family 8 member A1

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of SLC8A1 mRNA

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

G

solute carrier family 9 member A1

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A1 mRNA

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

solute carrier family 9 member A2

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A2 mRNA

NCBI chr 9:42,932,001...43,014,447
Ensembl chr 9:42,931,346...43,014,444

G

solute carrier family 9 member A3

multiple interactions

[o,p'-DDT co-treated with DDT] results in increased expression of SLC9A3 mRNA

NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417

G

solute carrier family 9 member A9

decreases methylation

DDT results in decreased methylation of SLC9A9 gene

NCBI chr 8:95,232,889...95,797,262
Ensembl chr 8:95,232,905...95,796,318

G

solute carrier organic anion transporter family, member 1a4

increases methylation

DDT results in increased methylation of SLCO1A4 gene

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

schlafen family member 4

increases methylation

DDT results in increased methylation of SLFN4 gene

NCBI chr10:67,994,601...68,018,141
Ensembl chr10:68,000,028...68,018,138
Ensembl chr10:68,000,028...68,018,138

G

spermine oxidase

decreases methylation

DDT results in decreased methylation of SMOX gene

NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710
Ensembl chr X:118,731,900...118,765,710

G

small nucleolar RNA host gene 11

increases expression

DDT results in increased expression of SNHG11 mRNA

NCBI chr 3:147,031,367...147,037,043

G

small nucleolar RNA, H/ACA box 38

decreases expression

DDT results in decreased expression of SNORA38 mRNA

NCBI chr20:3,660,900...3,661,033
Ensembl chr20:3,660,900...3,661,033
Ensembl chr 9:3,660,900...3,661,033

G

small nucleolar RNA, H/ACA box 53

decreases expression

DDT results in decreased expression of SNORA53 mRNA

NCBI chr 7:25,613,357...25,613,602
Ensembl chr 7:25,613,357...25,613,602

G

small nucleolar RNA, H/ACA box 5C

decreases expression

DDT results in decreased expression of SNORA5C mRNA

NCBI chr14:81,487,218...81,487,354
Ensembl chr14:81,487,218...81,487,354

G

small nucleolar RNA, H/ACA box 67

increases expression

DDT results in increased expression of SNORA67 mRNA

NCBI chr10:54,385,276...54,385,418
Ensembl chr10:54,385,276...54,385,418

G

small nucleolar RNA, H/ACA box 71A

increases expression

DDT results in increased expression of SNORA71A mRNA

NCBI chr 3:147,016,197...147,016,322
Ensembl chr 3:147,016,197...147,016,322

G

small nucleolar RNA, H/ACA box 84

decreases expression

DDT results in decreased expression of SNORA84 mRNA

NCBI chr15:24,461,537...24,461,669
Ensembl chr11:56,809,515...56,809,648

G

small nucleolar RNA, C/D box 101

increases expression

DDT results in increased expression of SNORD101 mRNA

NCBI chr 1:21,681,557...21,681,630
Ensembl chr 1:21,681,557...21,681,630

G

small nucleolar RNA, C/D box 104

decreases expression

DDT results in decreased expression of SNORD104 mRNA

NCBI chr10:91,435,313...91,435,382
Ensembl chr10:91,435,313...91,435,382

G

small nucleolar RNA, C/D box 118

decreases expression

DDT results in decreased expression of SNORD118 mRNA

NCBI chr10:53,774,811...53,774,946
Ensembl chr10:53,774,811...53,774,946

G

small nucleolar RNA, C/D box 12

decreases expression

DDT results in decreased expression of SNORD12 mRNA

NCBI chr 3:155,794,227...155,794,317
Ensembl chr 3:155,794,227...155,794,317

G

small nucleolar RNA, C/D box 37

decreases expression

DDT results in decreased expression of SNORD37 mRNA

NCBI chr 7:8,536,202...8,536,265
Ensembl chr 7:8,536,202...8,536,265

G

small nucleolar RNA, C/D box 38A

decreases expression

DDT results in decreased expression of SNORD38A mRNA

NCBI chr 5:130,631,069...130,631,136
Ensembl chr 5:130,631,069...130,631,136

G

small nucleolar RNA, C/D box 41

decreases expression

DDT results in decreased expression of SNORD41 mRNA

NCBI chr19:23,106,670...23,106,739
Ensembl chr19:23,106,670...23,106,739

G

small nucleolar RNA, C/D box 42B

decreases expression

DDT results in decreased expression of SNORD42B mRNA

NCBI chr10:63,078,825...63,078,893
Ensembl chr10:63,078,825...63,078,893

G

small nucleolar RNA, C/D box 43

increases expression

DDT results in increased expression of SNORD43 mRNA

NCBI chr 7:111,627,136...111,627,199
Ensembl chr 7:111,627,136...111,627,199

G

small nucleolar RNA, C/D box 48

decreases expression

DDT results in decreased expression of SNORD48 mRNA

NCBI chr20:3,877,283...3,877,346
Ensembl chr20:3,877,283...3,877,346

G

small nucleolar RNA, C/D box 71

decreases expression

DDT results in decreased expression of SNORD71 mRNA

NCBI chr19:37,806,869...37,806,952
Ensembl chr19:37,806,869...37,806,952

G

small nucleolar RNA, C/D box 8

decreases expression

DDT results in decreased expression of SNORD8 mRNA

NCBI chr15:24,917,836...24,917,945
Ensembl chr15:24,917,836...24,917,945

G

sorting nexin 24

decreases methylation

DDT results in decreased methylation of SNX24 gene

NCBI chr18:46,670,987...46,826,070
Ensembl chr18:46,671,443...46,826,068

G

superoxide dismutase 1

multiple interactions

[Polychlorinated Biphenyls co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Chlordan co-treated with nonachlor] inhibits the reaction [Fish Oils results in increased expression of SOD1 mRNA]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 3

increases expression

DDT results in increased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

SOS Ras/Rac guanine nucleotide exchange factor 1

multiple interactions

DDT promotes the reaction [GRB2 protein binds to SOS1 protein]

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

secreted protein acidic and cysteine rich

increases expression

DDT results in increased expression of SPARC mRNA

NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396

G

signal peptidase complex subunit 3

decreases expression

DDT results in decreased expression of SPCS3 mRNA

NCBI chr16:37,305,358...37,310,792
Ensembl chr16:37,305,305...37,331,746

G

secreted phosphoprotein 1

increases expression
decreases expression

DDT results in increased expression of SPP1 mRNA
DDT results in decreased expression of SPP1 mRNA

PMID:25014179 PMID:30207508

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sprouty-related, EVH1 domain containing 2

decreases methylation

DDT results in decreased methylation of SPRED2 gene

NCBI chr14:94,149,210...94,250,787
Ensembl chr14:94,148,837...94,249,162

G

spermatogenic leucine zipper 1

increases methylation

DDT results in increased methylation of SPZ1 gene

NCBI chr 2:23,796,741...23,798,337
Ensembl chr 2:23,796,742...23,798,337

G

sequestosome 1

increases expression

DDT results in increased expression of SQSTM1 mRNA

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 2

increases methylation

DDT results in increased methylation of SREBF2 gene

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

sulfiredoxin 1

increases expression

DDT results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

sarcospan

decreases expression

DDT results in decreased expression of SSPN mRNA

NCBI chr 4:178,890,030...178,946,267
Ensembl chr 4:178,897,147...178,931,554

G

somatostatin

decreases expression

DDT results in decreased expression of SST mRNA

NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173

G

suppression of tumorigenicity 7

increases methylation

DDT results in increased methylation of ST7 gene

NCBI chr 4:46,041,655...46,289,745
Ensembl chr 4:46,042,236...46,289,740

G

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

increases methylation

DDT results in increased methylation of ST8SIA1 gene

NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708

G

signal transducer and activator of transcription 1

increases phosphorylation

DDT results in increased phosphorylation of STAT1 protein

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions
affects localization

Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of and results in increased expression of STAT3 protein]; DDT results in increased phosphorylation of and results in increased expression of STAT3 protein; ruxolitinib inhibits the reaction [DDT results in increased phosphorylation of STAT3 protein]; WP1066 inhibits the reaction [DDT results in increased phosphorylation of STAT3 protein]
DDT affects the localization of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

stanniocalcin 1

decreases expression

DDT results in decreased expression of STC1 mRNA

NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264

G

serine/threonine kinase 11 interacting protein

increases methylation

DDT results in increased methylation of STK11IP gene

NCBI chr 9:77,012,297...77,027,989
Ensembl chr 9:77,012,693...77,027,873

G

sperm-tail PG-rich repeat containing 1

increases methylation

DDT results in increased methylation of STPG1 gene

NCBI chr 5:147,717,084...147,769,792
Ensembl chr 5:147,726,646...147,769,788

G

sperm-tail PG-rich repeat containing 2

increases methylation

DDT results in increased methylation of STPG2 gene

NCBI chr 2:227,764,266...228,285,664
Ensembl chr 2:227,764,353...228,285,663

G

syntaxin 8

increases methylation

DDT results in increased methylation of STX8 gene

NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993

G

syntaxin binding protein 6

decreases expression

DDT results in decreased expression of STXBP6 mRNA

NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024

G

sulfatase 1

decreases methylation

DDT results in decreased methylation of SULF1 gene

NCBI chr 5:6,362,894...6,526,174
Ensembl chr 5:6,362,911...6,525,584

G

spectrin repeat containing nuclear envelope protein 2

decreases expression

DDT results in decreased expression of SYNE2 mRNA

NCBI chr 6:94,537,088...94,848,085
Ensembl chr 6:94,537,088...94,848,064

G

synaptophysin

decreases expression

DDT results in decreased expression of SYP protein

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

TATA-box binding protein associated factor, RNA polymerase I subunit D

increases expression

DDT results in increased expression of TAF1D mRNA

NCBI chr 8:12,146,511...12,156,647
Ensembl chr 8:12,146,605...12,156,618

G

TATA-box binding protein associated factor 9b

increases methylation

DDT results in increased methylation of TAF9B gene

NCBI chr X:71,289,290...71,300,142
Ensembl chr X:71,289,290...71,300,604

G

transgelin 3

decreases methylation

DDT results in decreased methylation of TAGLN3 gene

NCBI chr11:55,099,887...55,113,457
Ensembl chr11:55,099,743...55,113,485

G

Tax1 binding protein 1

decreases expression

DDT results in decreased expression of TAX1BP1 mRNA

NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100

G

TBC1 domain family, member 4

decreases methylation

DDT results in decreased methylation of TBC1D4 gene

NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265

G

TBC1 domain family member 8B

decreases methylation

DDT results in decreased methylation of TBC1D8B gene

NCBI chr X:103,319,181...103,407,137
Ensembl chr X:103,319,340...103,407,133

G

T-box transcription factor 21

decreases methylation

DDT results in decreased methylation of TBX21 gene

NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831

G

tudor domain containing 7

decreases expression

DDT results in decreased expression of TDRD7 mRNA

NCBI chr 5:60,238,742...60,312,548
Ensembl chr 5:60,238,678...60,312,544

G

tet methylcytosine dioxygenase 1

decreases expression

DDT results in decreased expression of TET1 mRNA

NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052

G

trefoil factor 1

multiple interactions

[DDT results in increased activity of ESR1 protein] which results in increased expression of TFF1 mRNA

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

transforming growth factor, beta 1

multiple interactions

DDT inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 3

increases expression

DDT results in increased expression of TGFB3 mRNA

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

thrombospondin type 1 domain containing 7A

decreases expression

DDT results in decreased expression of THSD7A mRNA

NCBI chr 4:40,461,124...40,899,345
Ensembl chr 4:40,460,814...40,899,583

G

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

decreases expression

DDT results in decreased expression of TIE1 mRNA

NCBI chr 5:132,000,013...132,019,658
Ensembl chr 5:132,000,015...132,019,592

G

transmembrane protein 107

increases expression

DDT results in increased expression of TMEM107 mRNA

NCBI chr10:53,772,153...53,774,685
Ensembl chr10:53,771,784...53,774,676

G

transmembrane 131 like

increases methylation

DDT results in increased methylation of TMEM131L gene

NCBI chr 2:169,257,659...169,391,773
Ensembl chr 2:169,258,289...169,391,711

G

transmembrane protein 245

decreases expression

DDT results in decreased expression of TMEM245 mRNA

NCBI chr 5:71,570,952...71,647,915
Ensembl chr 5:71,514,858...71,647,763

G

transmembrane protein 39a

increases methylation

DDT results in increased methylation of TMEM39A gene

NCBI chr11:62,160,631...62,189,964
Ensembl chr11:62,160,631...62,189,964

G

transmembrane protein 47

decreases expression

DDT results in decreased expression of TMEM47 mRNA

NCBI chr X:45,421,405...45,447,900
Ensembl chr X:45,421,405...45,447,900

G

transmembrane O-mannosyltransferase targeting cadherins 2

increases methylation

DDT results in increased methylation of TMTC2 gene

NCBI chr 7:40,392,377...40,806,685
Ensembl chr 7:40,394,220...40,807,298

G

thioredoxin-related transmembrane protein 3

decreases expression

DDT results in decreased expression of TMX3 mRNA

NCBI chr18:83,731,777...83,764,719
Ensembl chr18:83,731,868...83,762,263

G

tumor necrosis factor

multiple interactions
increases expression
decreases expression

13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [DDT results in increased expression of TNF mRNA]; DDT inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; SB 203580 inhibits the reaction [DDT results in increased expression of TNF mRNA]
[DDT co-treated with o,p'-DDT] results in decreased expression of TNF mRNA
DDT metabolite results in decreased expression of TNF mRNA; DDT results in decreased expression of TNF mRNA

PMID:12007859 PMID:15603917 PMID:20865247 PMID:28412309 PMID:31521043

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11B

decreases expression

DDT results in decreased expression of TNFRSF11B mRNA

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 1A

decreases expression
increases expression

DDT results in decreased expression of TNFRSF1A mRNA
DDT results in increased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

tenascin N

decreases methylation

DDT results in decreased methylation of TNN gene

NCBI chr13:72,319,160...72,386,362
Ensembl chr13:72,319,155...72,408,156

G

tumor protein p53

multiple interactions
increases methylation
decreases expression

DDT inhibits the reaction [TRP53 protein binds to CDKN1A promoter]
DDT results in increased methylation of TP53 promoter
DDT results in decreased expression of TP53 mRNA; DDT results in decreased expression of TP53 protein
DDT results in decreased expression of TRP53 protein

PMID:23684557 PMID:25410620

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 binding protein, 2

increases methylation

DDT results in increased methylation of TP53BP2 gene

NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432

G

tumor protein p53 inducible nuclear protein 1

decreases expression

DDT results in decreased expression of TP53INP1 mRNA; DDT results in decreased expression of TP53INP1 protein

PMID:30207508 PMID:30421125

NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968

G

TPD52 like 3

increases methylation

DDT results in increased methylation of TPD52L3 gene

NCBI chr 1:227,781,173...227,785,040
Ensembl chr 1:227,773,724...227,784,467

G

tropomyosin 2

increases expression

DDT results in increased expression of TPM2 mRNA

NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992

G

translocated promoter region, nuclear basket protein

decreases expression

DDT results in decreased expression of TPR mRNA

NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496

G

Tnf receptor-associated factor 2

decreases methylation

DDT results in decreased methylation of TRAF2 gene

NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538

G

tRNA aspartic acid methyltransferase 1

increases methylation

DDT results in increased methylation of TRDMT1 gene

NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439

G

thyroid hormone receptor interactor 11

decreases expression

DDT results in decreased expression of TRIP11 mRNA

NCBI chr 6:120,995,242...121,067,693
Ensembl chr 6:120,998,733...121,067,781

G

TSC22 domain family, member 3

multiple interactions

DDT inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861

G

thyroid stimulating hormone receptor

decreases localization
decreases activity
multiple interactions

DDT results in decreased localization of TSHR protein
DDT results in decreased activity of TSHR protein
DDT binds to and results in decreased activity of TSHR protein

PMID:14759065 PMID:17062616 PMID:19214582

NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538

G

tetraspanin 14

increases methylation

DDT results in increased methylation of TSPAN14 gene

NCBI chr16:16,784,242...16,841,368
Ensembl chr16:16,783,234...16,841,400

G

transthyretin

decreases expression

DDT results in decreased expression of TTR mRNA

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

G

tubulin, alpha 3B

increases methylation

DDT results in increased methylation of TUBA3B gene

NCBI chr 4:178,588,779...178,594,328
Ensembl chr 4:178,588,779...178,594,326

G

thymidylate synthetase

decreases expression

DDT results in decreased expression of TYMS mRNA

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

ubiquitin C-terminal hydrolase L3

increases expression

DDT results in increased expression of UCHL3 mRNA

NCBI chr15:78,485,304...78,527,355
Ensembl chr15:78,485,315...78,527,355
Ensembl chr 3:78,485,315...78,527,355

G

UDP glucuronosyltransferase family 1 member A6

decreases expression

DDT results in decreased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

ubiquitin specific peptidase 25

decreases methylation

DDT results in decreased methylation of USP25 gene

NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348

G

vascular endothelial growth factor A

multiple interactions
decreases expression
increases expression

13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; zerumbone inhibits the reaction [DDT results in increased expression of VEGFA mRNA]
DDT results in decreased expression of VEGFA mRNA

PMID:20865247 PMID:31521043 PMID:33728745

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

increases expression

DDT results in increased expression of VIM mRNA; DDT results in increased expression of VIM protein

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

vacuole membrane protein 1

increases expression

DDT results in increased expression of VMP1 mRNA

NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007

G

vomeronasal 2 receptor, pseudogene 142

decreases methylation

DDT results in decreased methylation of VOM2R-PS142 gene

G

vomeronasal 2 receptor, 11

decreases methylation

DDT results in decreased methylation of VOM2R11 gene

NCBI chr 1:59,498,863...59,518,653
Ensembl chr 1:59,498,358...59,572,864

G

vomeronasal 2 receptor, 37

decreases methylation

DDT results in decreased methylation of VOM2R37 gene

NCBI chr 1:93,257,993...93,318,774
Ensembl chr 1:93,257,993...93,318,667

G

VRK serine/threonine kinase 2

decreases methylation

DDT results in decreased methylation of VRK2 gene

NCBI chr14:100,313,771...100,434,520
Ensembl chr14:100,313,601...100,434,527

G

vesicle transport through interaction with t-SNAREs 1A

increases methylation

DDT results in increased methylation of VTI1A gene

NCBI chr 1:254,356,343...254,661,854
Ensembl chr 1:254,356,429...254,661,852

G

von Willebrand factor A domain containing 5A

increases expression

DDT results in increased expression of VWA5A mRNA

NCBI chr 8:38,815,176...38,848,674
Ensembl chr 8:38,815,210...38,839,112

G

WW domain containing adaptor with coiled-coil

decreases methylation

DDT results in decreased methylation of WAC gene

NCBI chr17:55,922,686...55,984,286
Ensembl chr17:55,923,123...55,982,301

G

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2

decreases expression

DDT results in decreased expression of WFIKKN2 mRNA

NCBI chr10:79,185,563...79,191,657
Ensembl chr10:79,186,647...79,191,657

G

WD repeat and SOCS box-containing 1

increases expression

DDT results in increased expression of WSB1 mRNA

NCBI chr10:64,202,761...64,219,039
Ensembl chr10:64,202,763...64,219,019

G

WW domain containing transcription regulator 1

decreases methylation

DDT results in decreased methylation of WWTR1 gene

NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968

G

xanthine dehydrogenase

decreases expression

DDT results in decreased expression of XDH mRNA

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

X inactive specific transcript

increases expression

DDT results in increased expression of XIST mRNA

NCBI chr X:68,474,987...68,492,500

G

zinc finger and BTB domain containing 20

decreases expression

DDT results in decreased expression of ZBTB20 mRNA

NCBI chr11:57,052,129...57,791,214
Ensembl chr11:57,072,880...57,510,210

G

zinc finger CCCH-type containing 18

increases methylation

DDT results in increased methylation of ZC3H18 gene

NCBI chr19:50,434,864...50,479,855
Ensembl chr19:50,434,903...50,479,854

G

zinc finger, DHHC-type containing 11

decreases methylation

DDT results in decreased methylation of ZDHHC11 gene

NCBI chr 1:29,296,334...29,327,227
Ensembl chr 1:29,296,334...29,326,898

G

zinc finger DHHC-type palmitoyltransferase 20

decreases expression

DDT results in decreased expression of ZDHHC20 mRNA

NCBI chr15:31,980,057...32,039,006
Ensembl chr15:31,983,155...32,038,989

G

zinc finger protein 157

increases methylation

DDT results in increased methylation of ZFP157 gene

NCBI chr12:16,248,230...16,279,459
Ensembl chr12:16,248,230...16,270,698

G

zinc finger protein 523

increases methylation

DDT results in increased methylation of ZFP523 gene

NCBI chr20:6,234,884...6,266,512
Ensembl chr20:6,243,582...6,266,511

G

zinc finger protein 608

decreases expression

DDT results in decreased expression of ZFP608 mRNA

NCBI chr18:48,304,873...48,412,846
Ensembl chr18:48,304,880...48,410,465

G

zinc finger protein 704

decreases expression

DDT results in decreased expression of ZFP704 mRNA

NCBI chr 2:92,171,804...92,356,059
Ensembl chr 2:92,171,496...92,351,282

G

zinc finger protein, multitype 2

increases methylation

DDT results in increased methylation of ZFPM2 gene

NCBI chr 7:71,678,658...72,116,209
Ensembl chr 7:71,678,880...72,116,205

G

zona pellucida binding protein

decreases methylation

DDT results in decreased methylation of ZPBP gene

NCBI chr14:85,830,971...86,030,778
Ensembl chr14:85,833,548...86,033,095

G

zinc finger, SWIM-type containing 4

increases methylation

DDT results in increased methylation of ZSWIM4 gene

NCBI chr19:23,927,845...23,952,970
Ensembl chr19:23,927,845...23,952,970

dicofol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

multiple interactions

Dicofol binds to and affects the folding of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

androgen receptor

affects binding
multiple interactions

Dicofol binds to AR protein
Dicofol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dicofol inhibits the reaction [Metribolone results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [Dicofol results in increased activity of AR protein]

PMID:15064155 PMID:15253041 PMID:18324785 PMID:21310686

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

Dicofol results in decreased activity of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Dicofol results in increased expression of CYP1A1 mRNA; Dicofol results in increased expression of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

Dicofol results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

Dicofol results in increased expression of CYP2B1 protein

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

Dicofol results in increased expression of CYP2B2 protein

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

Dicofol results in increased expression of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

Dicofol results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

iodothyronine deiodinase 1

decreases activity

Dicofol results in decreased activity of DIO1 protein

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

estrogen receptor 1

affects binding
multiple interactions
increases activity

Dicofol binds to ESR1 protein
Dicofol binds to and results in increased activity of ESR1 protein
Dicofol results in increased activity of ESR1 protein

PMID:10789375 PMID:15064155 PMID:15253041 PMID:16337670 PMID:29162470

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases activity

Dicofol results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

gamma-glutamyltransferase 1

increases activity

Dicofol results in increased activity of GGT1 protein