|
G |
AHR |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin; [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
|
NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
|
|
G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
EXP |
[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
|
NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
|
|
G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
EXP |
Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA; Tetrachlorodibenzodioxin results in increased expression of PTGS2 protein |
CTD |
PMID:8660662 |
|
NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
|
|
G |
TERT |
telomerase reverse transcriptase |
decreases expression |
EXP |
Tetrachlorodibenzodioxin results in decreased expression of TERT protein |
CTD |
PMID:23850740 |
|
NCBI chr34:11,288,622...11,307,790
Ensembl chr34:11,288,622...11,307,951
|
|
|
G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity |
EXP |
6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I2 protein |
CTD |
PMID:27732639 |
|
NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
|
|
G |
NR1I3 |
nuclear receptor subfamily 1 group I member 3 |
increases activity |
EXP |
6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein mutant form |
CTD |
PMID:21778469 |
|
NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827
|
|
|
G |
CFTR |
CF transmembrane conductance regulator |
multiple interactions |
EXP |
[1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein |
CTD |
PMID:15161604 |
|
NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
|
|
|
G |
REN |
renin |
increases expression |
EXP |
Amlodipine results in increased expression of REN protein |
CTD |
PMID:10218729 |
|
NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
|
|
|
G |
AHR |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
[Chlorodiphenyl (54% Chlorine) binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
|
NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
|
|
G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
EXP |
[Chlorodiphenyl (54% Chlorine) binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
|
NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
|
|
|
G |
MGMT |
O-6-methylguanine-DNA methyltransferase |
decreases response to substance multiple interactions |
EXP |
MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine] |
CTD |
PMID:14617759 PMID:15053863 |
|
NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380
|
|
|
G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
EXP |
carprofen results in decreased expression of PTGS2 mRNA |
CTD |
PMID:15198222 |
|
NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
|
|
|
G |
KCNH2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions |
EXP |
Cisapride binds to and results in decreased activity of KCNH2 protein |
CTD |
PMID:12388285 |
|
NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504
|
|
|
G |
ACAA2 |
acetyl-CoA acyltransferase 2 |
increases expression |
EXP |
Clofibrate results in increased expression of ACAA2 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr 7:79,028,636...79,057,720
|
|
G |
ACADVL |
acyl-CoA dehydrogenase very long chain |
increases expression |
EXP |
Clofibrate results in increased expression of ACADVL protein |
CTD |
PMID:19952500 |
|
NCBI chr 5:32,189,191...32,194,255
Ensembl chr 5:32,186,502...32,327,990
|
|
G |
AGXT |
alanine--glyoxylate and serine--pyruvate aminotransferase |
decreases expression |
EXP |
Clofibrate results in decreased expression of AGXT protein |
CTD |
PMID:19952500 |
|
NCBI chr25:50,968,291...50,976,089
|
|
G |
AHCY |
adenosylhomocysteinase |
decreases expression |
EXP |
Clofibrate results in decreased expression of AHCY protein |
CTD |
PMID:19952500 |
|
NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767
|
|
G |
ASL |
argininosuccinate lyase |
increases expression |
EXP |
Clofibrate results in increased expression of ASL protein |
CTD |
PMID:19952500 |
|
NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424
|
|
G |
ASS1 |
argininosuccinate synthase 1 |
decreases expression |
EXP |
Clofibrate results in decreased expression of ASS1 protein |
CTD |
PMID:19952500 |
|
NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904
|
|
G |
CPS1 |
carbamoyl-phosphate synthase 1 |
increases expression |
EXP |
Clofibrate results in increased expression of CPS1 protein |
CTD |
PMID:19952500 |
|
NCBI chr37:18,308,164...18,428,487
Ensembl chr37:18,143,986...18,427,697
|
|
G |
CPT2 |
carnitine palmitoyltransferase 2 |
increases expression |
EXP |
Clofibrate results in increased expression of CPT2 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr 5:55,718,209...55,786,175
Ensembl chr 5:55,718,510...55,744,809
|
|
G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
decreases expression |
EXP |
Clofibrate results in decreased expression of CYP1A2 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
|
|
G |
CYP2A13 |
cytochrome P450 family 2 subfamily A polypeptide 13 |
decreases expression |
EXP |
Clofibrate results in decreased expression of CYP2A13 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350
|
|
G |
CYP2B6 |
cytochrome P450 2B11 |
decreases expression |
EXP |
Clofibrate results in decreased expression of CYP2B6 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
|
|
G |
CYP2C18 |
cytochrome P450 2C21 |
decreases expression |
EXP |
Clofibrate results in decreased expression of CYP2C18 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
|
|
G |
CYP2E1 |
cytochrome P450 family 2 subfamily E member 1 |
increases expression |
EXP |
Clofibrate results in increased expression of CYP2E1 protein |
CTD |
PMID:19952500 |
|
NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754
|
|
G |
CYP3A12 |
cytochrome P-450 3A12 |
decreases expression |
EXP |
Clofibrate results in decreased expression of CYP3A12 mRNA |
CTD |
PMID:19952500 |
|
|
|
G |
CYP3A26 |
cytochrome P450 3A26 |
decreases expression |
EXP |
Clofibrate results in decreased expression of CYP3A26 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352
|
|
G |
CYP4A37 |
cytochrome P450 4A37 |
increases expression |
EXP |
Clofibrate results in increased expression of CYP4A11 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr15:13,604,130...13,623,797
|
|
G |
DLST |
dihydrolipoamide S-succinyltransferase |
increases expression |
EXP |
Clofibrate results in increased expression of DLST protein |
CTD |
PMID:19952500 |
|
NCBI chr 8:48,003,730...48,025,001
Ensembl chr 8:48,002,211...48,024,999
|
|
G |
ECHS1 |
enoyl-CoA hydratase, short chain 1 |
increases expression |
EXP |
Clofibrate results in increased expression of ECHS1 protein |
CTD |
PMID:19952500 |
|
NCBI chr28:40,939,856...40,947,694
Ensembl chr28:40,939,961...40,946,167
|
|
G |
GDI1 |
GDP dissociation inhibitor 1 |
increases expression |
EXP |
Clofibrate results in increased expression of GDI1 protein |
CTD |
PMID:19952500 |
|
NCBI chr X:122,141,633...122,146,724
Ensembl chr X:122,141,566...122,146,824
|
|
G |
GSTA4 |
glutathione S-transferase alpha 4 |
decreases expression |
EXP |
Clofibrate results in decreased expression of GSTA4 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200
|
|
G |
GSTK1 |
glutathione S-transferase kappa 1 |
decreases expression |
EXP |
Clofibrate results in decreased expression of GSTK1 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr16:6,411,678...6,416,135
|
|
G |
GSTO1 |
glutathione S-transferase omega 1 |
decreases expression |
EXP |
Clofibrate results in decreased expression of GSTO1 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880
|
|
G |
HADH |
hydroxyacyl-CoA dehydrogenase |
increases expression |
EXP |
Clofibrate results in increased expression of HADH mRNA |
CTD |
PMID:19952500 |
|
NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280
|
|
G |
HSPD1 |
heat shock protein family D (Hsp60) member 1 |
increases expression |
EXP |
Clofibrate results in increased expression of HSPD1 protein |
CTD |
PMID:19952500 |
|
NCBI chr37:7,010,421...7,025,912
|
|
G |
KRT1 |
keratin 1 |
increases expression |
EXP |
Clofibrate results in increased expression of KRT1 protein |
CTD |
PMID:19952500 |
|
NCBI chr27:2,422,150...2,427,160
|
|
G |
KRT18 |
keratin 18 |
decreases expression |
EXP |
Clofibrate results in decreased expression of KRT18 protein |
CTD |
PMID:19952500 |
|
NCBI chr27:2,189,269...2,193,368
Ensembl chr27:2,189,269...2,193,368
|
|
G |
LOC474938 |
glutathione S-transferase A2 |
decreases expression |
EXP |
Clofibrate results in decreased expression of GSTA3 mRNA; Clofibrate results in decreased expression of GSTA3 protein |
CTD |
PMID:19952500 |
|
NCBI chr12:20,349,133...20,365,023
|
|
G |
MGST1 |
microsomal glutathione S-transferase 1 |
increases expression |
EXP |
Clofibrate results in increased expression of MGST1 mRNA |
CTD |
PMID:19952500 |
|
NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778
|
|
G |
PC |
pyruvate carboxylase |
increases expression |
EXP |
Clofibrate results in increased expression of PC protein |
CTD |
PMID:19952500 |
|
NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669
|
|
G |
PCK2 |
phosphoenolpyruvate carboxykinase 2, mitochondrial |
increases expression |
EXP |
Clofibrate results in increased expression of PCK2 protein |
CTD |
PMID:19952500 |
|
NCBI chr 8:4,099,016...4,107,870
Ensembl chr 8:4,098,671...4,107,865
|
|
G |
PRDX6 |
peroxiredoxin 6 |
decreases expression |
EXP |
Clofibrate results in decreased expression of PRDX6 protein |
CTD |
PMID:19952500 |
|
NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754
|
|
G |
SELENBP1 |
selenium binding protein 1 |
decreases expression |
EXP |
Clofibrate results in decreased expression of SELENBP1 protein |
CTD |
PMID:19952500 |
|
NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704
|
|
G |
SHMT1 |
serine hydroxymethyltransferase 1 |
decreases expression |
EXP |
Clofibrate results in decreased expression of SHMT1 protein |
CTD |
PMID:19952500 |
|
NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166
|
|
G |
UGP2 |
UDP-glucose pyrophosphorylase 2 |
decreases expression |
EXP |
Clofibrate results in decreased expression of UGP2 protein |
CTD |
PMID:19952500 |
|
NCBI chr10:63,532,366...63,598,362
Ensembl chr10:63,533,171...63,597,452
|
|
G |
UQCRC1 |
ubiquinol-cytochrome c reductase core protein 1 |
increases expression |
EXP |
Clofibrate results in increased expression of UQCRC1 protein |
CTD |
PMID:19952500 |
|
NCBI chr20:40,507,767...40,515,854
Ensembl chr20:40,506,907...40,520,110
|
|
G |
UROC1 |
urocanate hydratase 1 |
decreases expression |
EXP |
Clofibrate results in decreased expression of UROC1 protein |
CTD |
PMID:19952500 |
|
NCBI chr20:676,624...717,109
Ensembl chr20:678,073...717,141
|
|
|
G |
ADRA2A |
adrenoceptor alpha 2A |
multiple interactions increases response to substance |
EXP |
Clonidine binds to and results in increased activity of ADRA2A protein ADRA2A protein results in increased susceptibility to Clonidine |
CTD |
PMID:16814767 |
|
NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684
|
|
G |
ADRA2C |
adrenoceptor alpha 2C |
increases response to substance |
EXP |
ADRA2C protein results in increased susceptibility to Clonidine |
CTD |
PMID:16814767 |
|
NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722
|
|
G |
GH1 |
growth hormone |
increases secretion |
EXP |
Clonidine results in increased secretion of GH1 protein |
CTD |
PMID:6248808 |
|
NCBI chr 9:11,832,265...11,834,123
Ensembl chr 9:11,832,265...11,834,123
|
|
G |
NISCH |
nischarin |
multiple interactions affects binding |
EXP |
Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein] |
CTD |
PMID:24120658 |
|
NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636
|
|
G |
PIK3CG |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma |
multiple interactions increases activity |
EXP |
[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] |
CTD |
PMID:15958164 |
|
NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
|
|
G |
PRKCZ |
protein kinase C zeta |
multiple interactions increases phosphorylation |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] |
CTD |
PMID:15958164 |
|
NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
|
|
G |
REN |
renin |
multiple interactions decreases activity |
EXP |
Clonidine results in decreased secretion of and results in decreased activity of REN protein Clonidine results in decreased activity of REN protein |
CTD |
PMID:6248808 PMID:6991409 |
|
NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
|
|
|
G |
ADRA2A |
adrenoceptor alpha 2A |
multiple interactions increases response to substance |
EXP |
Clonidine binds to and results in increased activity of ADRA2A protein ADRA2A protein results in increased susceptibility to Clonidine |
CTD |
PMID:16814767 |
|
NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684
|
|
G |
ADRA2C |
adrenoceptor alpha 2C |
increases response to substance |
EXP |
ADRA2C protein results in increased susceptibility to Clonidine |
CTD |
PMID:16814767 |
|
NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722
|
|
G |
GH1 |
growth hormone |
increases secretion |
EXP |
Clonidine results in increased secretion of GH1 protein |
CTD |
PMID:6248808 |
|
NCBI chr 9:11,832,265...11,834,123
Ensembl chr 9:11,832,265...11,834,123
|
|
G |
NISCH |
nischarin |
affects binding multiple interactions |
EXP |
Clonidine binds to NISCH protein Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein] |
CTD |
PMID:24120658 |
|
NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636
|
|
G |
PIK3CG |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma |
increases activity multiple interactions |
EXP |
Clonidine results in increased activity of PIK3CG protein [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] |
CTD |
PMID:15958164 |
|
NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
|
|
G |
PRKCZ |
protein kinase C zeta |
multiple interactions increases phosphorylation |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] |
CTD |
PMID:15958164 |
|
NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
|
|
G |
REN |
renin |
multiple interactions decreases activity |
EXP |
Clonidine results in decreased secretion of and results in decreased activity of REN protein Clonidine results in decreased activity of REN protein |
CTD |
PMID:6248808 PMID:6991409 |
|
NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
|
|
|
G |
ADRA2A |
adrenoceptor alpha 2A |
multiple interactions increases response to substance |
EXP |
Clonidine binds to and results in increased activity of ADRA2A protein ADRA2A protein results in increased susceptibility to Clonidine |
CTD |
PMID:16814767 |
|
NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684
|
|
G |
ADRA2C |
adrenoceptor alpha 2C |
increases response to substance |
EXP |
ADRA2C protein results in increased susceptibility to Clonidine |
CTD |
PMID:16814767 |
|
NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722
|
|
G |
GH1 |
growth hormone |
increases secretion |
EXP |
Clonidine results in increased secretion of GH1 protein |
CTD |
PMID:6248808 |
|
NCBI chr 9:11,832,265...11,834,123
Ensembl chr 9:11,832,265...11,834,123
|
|
G |
NISCH |
nischarin |
affects binding multiple interactions |
EXP |
Clonidine binds to NISCH protein Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein] |
CTD |
PMID:24120658 |
|
NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636
|
|
G |
PIK3CG |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma |
multiple interactions increases activity |
EXP |
[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] |
CTD |
PMID:15958164 |
|
NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
|
|
G |
PRKCZ |
protein kinase C zeta |
multiple interactions increases phosphorylation |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] |
CTD |
PMID:15958164 |
|
NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
|
|
G |
REN |
renin |
multiple interactions decreases activity |
EXP |
Clonidine results in decreased secretion of and results in decreased activity of REN protein Clonidine results in decreased activity of REN protein |
CTD |
PMID:6248808 PMID:6991409 |
|
NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
|
|
|
G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity |
EXP |
Clotrimazole results in increased activity of NR1I2 protein |
CTD |
PMID:27732639 |
|
NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
|
|
G |
NR1I3 |
nuclear receptor subfamily 1 group I member 3 |
affects binding increases activity |
EXP |
Clotrimazole binds to NR1I3 protein Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein mutant form |
CTD |
PMID:21778469 PMID:27732639 |
|
NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827
|
|
|
G |
INS |
insulin |
multiple interactions |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:12639917 |
|
NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
|
|
G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:12639917 |
|
NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
|
|
G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Colforsin co-treated with INS protein] results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:12639917 |
|
NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
|
|
G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity |
EXP |
Colforsin results in increased activity of NR1I2 protein |
CTD |
PMID:27732639 |
|
NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
|
|
|
G |
CYP2B6 |
cytochrome P450 2B11 |
increases hydroxylation |
EXP |
CYP2B6 protein results in increased hydroxylation of Cyclophosphamide |
CTD |
PMID:16546968 |
|
NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
|
|
|
G |
CDIPT |
CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
decreases activity multiple interactions |
EXP |
delta-hexachlorocyclohexane results in decreased activity of CDIPT protein [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate |
CTD |
PMID:2579070 |
|
NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653
|
|
|
G |
CYP2C18 |
cytochrome P450 2C21 |
affects metabolic processing |
EXP |
CYP2C19 protein affects the metabolism of Diazepam |
CTD |
PMID:15801540 |
|
NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
|
|
G |
CYP3A12 |
cytochrome P-450 3A12 |
multiple interactions increases hydroxylation |
EXP |
Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam] |
CTD |
PMID:15677349 |
|
|
|
|
G |
ACHE |
acetylcholinesterase |
decreases activity |
EXP |
Dichlorvos results in decreased activity of ACHE protein |
CTD |
PMID:89824 PMID:3627083 |
|
NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
|
|
G |
BCHE |
butyrylcholinesterase |
decreases activity |
EXP |
Dichlorvos results in decreased activity of BCHE protein |
CTD |
PMID:3627083 PMID:4631366 |
|
NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
|
|
|
G |
CYP2C18 |
cytochrome P450 2C21 |
increases hydroxylation |
EXP |
CYP2C19 protein results in increased hydroxylation of Diclofenac |
CTD |
PMID:15677349 |
|
NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
|
|
G |
CYP2C41 |
cytochrome P450 2C41 |
affects metabolic processing |
EXP |
CYP2C9 protein affects the metabolism of Diclofenac |
CTD |
PMID:15801540 |
|
|
|
G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Diclofenac results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
|
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
|
|
|
G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity |
EXP |
Felodipine results in increased activity of NR1I2 protein |
CTD |
PMID:27732639 |
|
NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
|
|
|
G |
CDIPT |
CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
multiple interactions affects activity |
EXP |
[Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate |
CTD |
PMID:2579070 |
|
NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653
|
|
|
G |
CFTR |
CF transmembrane conductance regulator |
decreases activity |
EXP |
Glyburide results in decreased activity of CFTR protein |
CTD |
PMID:15496164 |
|
NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
|
|
|
G |
SLC47A1 |
solute carrier family 47 member 1 |
decreases activity |
EXP |
hexaconazole results in decreased activity of SLC47A1 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946
|
|
G |
SLC47A2 |
solute carrier family 47 member 2 |
decreases activity |
EXP |
hexaconazole results in decreased activity of SLC47A2 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,491,306...40,515,430
Ensembl chr 5:40,491,933...40,540,136
|
|
|
G |
ATP5F1B |
ATP synthase F1 subunit beta |
multiple interactions decreases expression |
EXP |
[Hydrochloric Acid co-treated with Bile Acids and Salts] results in decreased expression of ATP5F1B mRNA Hydrochloric Acid results in decreased expression of ATP5F1B mRNA |
CTD |
PMID:15883737 |
|
NCBI chr10:870,405...876,937
Ensembl chr10:870,392...909,161
|
|
G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
increases expression multiple interactions |
EXP |
Hydrochloric Acid results in increased expression of CXCL8 protein Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL8 protein] |
CTD |
PMID:18339021 |
|
NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354
|
|
G |
FGF7 |
fibroblast growth factor 7 |
increases expression |
EXP |
Hydrochloric Acid results in increased expression of FGF7 mRNA |
CTD |
PMID:15883737 |
|
NCBI chr30:15,555,016...15,608,230
Ensembl chr30:15,555,266...15,606,521
|
|
G |
FGFR2 |
fibroblast growth factor receptor 2 |
increases expression |
EXP |
Hydrochloric Acid results in increased expression of FGFR2 mRNA |
CTD |
PMID:15883737 |
|
NCBI chr28:31,303,882...31,411,015
Ensembl chr28:31,303,894...31,411,621
|
|
G |
MMP2 |
matrix metallopeptidase 2 |
increases expression multiple interactions |
EXP |
Hydrochloric Acid results in increased expression of MMP2 protein Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP2 protein] |
CTD |
PMID:18339021 |
|
NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113
|
|
G |
MMP9 |
matrix metallopeptidase 9 |
increases expression multiple interactions |
EXP |
Hydrochloric Acid results in increased expression of MMP9 protein Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP9 protein] |
CTD |
PMID:18339021 |
|
NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
|
|
G |
NOS2 |
nitric oxide synthase 2 |
increases activity |
EXP |
Hydrochloric Acid results in increased activity of NOS2 protein |
CTD |
PMID:14621274 |
|
NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588
|
|
|
G |
HEXB |
hexosaminidase subunit beta |
multiple interactions |
EXP |
Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein] |
CTD |
PMID:21671308 |
|
NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
|
|
G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Indomethacin results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
|
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
|
|
|
G |
AHR |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
[iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
|
NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
|
|
G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
EXP |
[iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
|
NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
|
|
|
G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
decreases expression multiple interactions decreases activity |
EXP |
Ketoconazole results in decreased expression of ABCB1 mRNA [Ketoconazole results in decreased activity of ABCB1 protein] which results in decreased transport of Technetium Tc 99m Sestamibi |
CTD |
PMID:19754906 PMID:22620706 |
|
NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
|
|
G |
CYP3A12 |
cytochrome P-450 3A12 |
multiple interactions decreases activity |
EXP |
Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam] Ketoconazole results in decreased activity of CYP3A12 protein |
CTD |
PMID:15677349 |
|
|
|
|
G |
EDN1 |
endothelin 1 |
increases secretion |
EXP |
lead chloride results in increased secretion of EDN1 protein |
CTD |
PMID:15915659 |
|
NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
|
|
G |
EDN2 |
endothelin 2 |
increases secretion |
EXP |
lead chloride results in increased secretion of EDN2 protein |
CTD |
PMID:15915659 |
|
NCBI chr15:1,647,966...1,654,272
Ensembl chr15:1,648,077...1,654,272
|
|
|
G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
affects response to substance increases export |
EXP |
ABCB1 protein affects the susceptibility to Loperamide ABCB1 protein results in increased export of Loperamide |
CTD |
PMID:25660379 PMID:28093773 |
|
NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
|
|
|
G |
CASP3 |
caspase 3 |
increases activity |
EXP |
Loratadine results in increased activity of CASP3 protein |
CTD |
PMID:20570632 |
|
NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
|
|
|
G |
REN |
renin |
increases expression |
EXP |
losartan carboxylic acid results in increased expression of REN protein |
CTD |
PMID:10483973 |
|
NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
|
|
|
G |
PIK3CG |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma |
multiple interactions |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein] |
CTD |
PMID:15958164 |
|
NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
|
|
G |
PRKCZ |
protein kinase C zeta |
multiple interactions |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] |
CTD |
PMID:15958164 |
|
NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
|
|
|
G |
CYP3A4 |
cytochrome P450, family 3, subfamily A, polypeptide 4 |
affects metabolic processing |
EXP |
CYP3A4 protein affects the metabolism of Midazolam; CYP3A5 protein affects the metabolism of Midazolam |
CTD |
PMID:15801540 |
|
NCBI chr 6:9,836,685...9,869,520
Ensembl chr 6:9,777,659...9,869,352
|
|
|
G |
ACTA2 |
actin alpha 2, smooth muscle |
multiple interactions increases expression |
EXP |
CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein] ochratoxin A results in increased expression of ACTA2 mRNA; ochratoxin A results in increased expression of ACTA2 protein |
CTD |
PMID:33543323 |
|
NCBI chr26:38,700,434...38,714,915
Ensembl chr26:38,700,480...38,711,753
|
|
G |
B9D2 |
B9 domain containing 2 |
increases expression multiple interactions |
EXP |
ochratoxin A results in increased expression of TGFB1 mRNA; ochratoxin A results in increased expression of TGFB1 protein CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein] |
CTD |
PMID:33543323 |
|
NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
|
|
G |
CASP4 |
caspase 4, apoptosis-related cysteine peptidase |
increases expression multiple interactions increases cleavage |
EXP |
ochratoxin A results in increased expression of CASP1 mRNA CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA] |
CTD |
PMID:33543323 |
|
NCBI chr 5:27,133,778...27,147,954
Ensembl chr 5:27,132,565...27,149,736
|
|
G |
GSDMD |
gasdermin D |
multiple interactions increases expression |
EXP |
CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein] ochratoxin A results in increased expression of GSDMD mRNA; ochratoxin A results in increased expression of GSDMD protein |
CTD |
PMID:33543323 |
|
NCBI chr13:37,221,219...37,226,912
Ensembl chr13:37,193,022...37,228,360
|
|
G |
IL18 |
interleukin 18 |
multiple interactions increases expression |
EXP |
CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA] |
CTD |
PMID:33543323 |
|
NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348
|
|
G |
IL1B |
interleukin 1 beta |
multiple interactions increases expression |
EXP |
CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein] ochratoxin A results in increased expression of IL1B mRNA; ochratoxin A results in increased expression of IL1B protein |
CTD |
PMID:33543323 |
|
NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
|
|
G |
IL6 |
interleukin 6 |
increases secretion increases expression |
EXP |
ochratoxin A results in increased secretion of IL6 protein ochratoxin A results in increased expression of IL6 mRNA |
CTD |
PMID:33543323 |
|
NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
|
|
G |
NLRP3 |
NLR family pyrin domain containing 3 |
multiple interactions increases expression |
EXP |
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein] ochratoxin A results in increased expression of NLRP3 mRNA; ochratoxin A results in increased expression of NLRP3 protein |
CTD |
PMID:33543323 |
|
NCBI chr 8:251,776...313,290
Ensembl chr 8:253,407...313,059
|
|
G |
PYCARD |
PYD and CARD domain containing |
increases expression multiple interactions |
EXP |
ochratoxin A results in increased expression of PYCARD mRNA; ochratoxin A results in increased expression of PYCARD protein N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein] |
CTD |
PMID:33543323 |
|
NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240
|
|
G |
TNF |
tumor necrosis factor |
increases secretion increases expression |
EXP |
ochratoxin A results in increased secretion of TNF protein ochratoxin A results in increased expression of TNF mRNA |
CTD |
PMID:33543323 |
|
NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
|
|
G |
VIM |
vimentin |
multiple interactions increases expression |
EXP |
CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of VIM protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein] ochratoxin A results in increased expression of VIM mRNA; ochratoxin A results in increased expression of VIM protein |
CTD |
PMID:33543323 |
|
NCBI chr 2:19,671,316...19,679,367
Ensembl chr 2:19,671,316...19,679,466
|
|
|
G |
SLC22A2 |
solute carrier family 22 member 2 |
decreases activity |
EXP |
penconazole results in decreased activity of SLC22A2 protein |
CTD |
PMID:36669674 |
|
NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435
|
|
G |
SLC22A5 |
solute carrier family 22 member 5 |
decreases activity |
EXP |
penconazole results in decreased activity of SLC22A5 protein |
CTD |
PMID:36669674 |
|
NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087
|
|
G |
SLC47A1 |
solute carrier family 47 member 1 |
decreases activity |
EXP |
penconazole results in decreased activity of SLC47A1 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946
|
|
G |
SLC47A2 |
solute carrier family 47 member 2 |
decreases activity |
EXP |
penconazole results in decreased activity of SLC47A2 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,491,306...40,515,430
Ensembl chr 5:40,491,933...40,540,136
|
|
|
G |
AHR |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz |
CTD |
PMID:24389113 |
|
NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
|
|
G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
EXP |
[prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
|
NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
|
|
|
G |
HEXB |
hexosaminidase subunit beta |
multiple interactions |
EXP |
Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein] |
CTD |
PMID:21671308 |
|
NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
|
|
|
G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
increases export |
EXP |
ABCB1 protein results in increased export of Rhodamine 123 |
CTD |
PMID:28093773 |
|
NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
|
|
|
G |
CLDN4 |
claudin 4 |
increases expression multiple interactions |
EXP |
Sodium Chloride results in increased expression of CLDN4 protein Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] |
CTD |
PMID:23816505 |
|
NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
|
|
G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP |
Sodium Chloride results in increased expression of JUN protein pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]] |
CTD |
PMID:23816505 |
|
NCBI chr 5:50,966,698...50,968,939
|
|
G |
MAPK1 |
mitogen-activated protein kinase 1 |
increases phosphorylation multiple interactions |
EXP |
Sodium Chloride results in increased phosphorylation of MAPK1 protein Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:23816505 |
|
NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
|
|
G |
MAPK3 |
mitogen-activated protein kinase 3 |
increases phosphorylation multiple interactions |
EXP |
Sodium Chloride results in increased phosphorylation of MAPK3 protein Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:23816505 |
|
NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
|
|
G |
MAPK8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
EXP |
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:23816505 |
|
NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
|
|
G |
MAPK9 |
mitogen-activated protein kinase 9 |
multiple interactions increases phosphorylation |
EXP |
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:23816505 |
|
NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
|
|
G |
SOD2 |
superoxide dismutase 2 |
increases expression |
EXP |
Sodium Chloride results in increased expression of SOD2 protein |
CTD |
PMID:22718889 |
|
NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
|
|
G |
SP1 |
Sp1 transcription factor |
multiple interactions increases expression |
EXP |
pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein] |
CTD |
PMID:23816505 |
|
NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226
|
|
|
G |
CNR2 |
cannabinoid receptor 2 |
multiple interactions |
EXP |
SR 144528 binds to and results in decreased activity of CNR2 protein |
CTD |
PMID:21871882 |
|
NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126
|
|
|
G |
SLC22A2 |
solute carrier family 22 member 2 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC22A2 protein |
CTD |
PMID:36669674 |
|
NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435
|
|
G |
SLC22A5 |
solute carrier family 22 member 5 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC22A5 protein |
CTD |
PMID:36669674 |
|
NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087
|
|
G |
SLC47A1 |
solute carrier family 47 member 1 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC47A1 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946
|
|
G |
SLC47A2 |
solute carrier family 47 member 2 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC47A2 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,491,306...40,515,430
Ensembl chr 5:40,491,933...40,540,136
|
|
|
G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
EXP |
tolfenamic acid results in decreased expression of PTGS2 mRNA |
CTD |
PMID:15198222 |
|
NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
|
|
|
G |
SLC22A5 |
solute carrier family 22 member 5 |
decreases activity |
EXP |
triticonazole results in decreased activity of SLC22A5 protein |
CTD |
PMID:36669674 |
|
NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087
|
|
G |
SLC47A1 |
solute carrier family 47 member 1 |
decreases activity |
EXP |
triticonazole results in decreased activity of SLC47A1 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946
|
|
|
G |
SLC22A5 |
solute carrier family 22 member 5 |
decreases activity |
EXP |
uniconazole results in decreased activity of SLC22A5 protein |
CTD |
PMID:36669674 |
|
NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087
|
|
G |
SLC47A1 |
solute carrier family 47 member 1 |
decreases activity |
EXP |
uniconazole results in decreased activity of SLC47A1 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946
|
|