chelate-forming peptide - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	chelate-forming peptide	go back to main search page
Accession:	CHEBI:23089	browse the term

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Genes (721)

bleomycin A2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 3

decreases expression

Bleomycin results in decreased expression of ABCA3 mRNA; Bleomycin results in decreased expression of ABCA3 protein

NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745

G

angiotensin I converting enzyme

multiple interactions
decreases expression

angiotensin I (1-7) inhibits the reaction [Bleomycin results in decreased expression of ACE protein]

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

multiple interactions
decreases expression

angiotensin I (1-7) inhibits the reaction [Bleomycin results in decreased expression of ACE2 mRNA]

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

actin alpha 2, smooth muscle

increases expression
multiple interactions
decreases expression

Bleomycin results in increased expression of ACTA2 mRNA; Bleomycin results in increased expression of ACTA2 protein
Ephedrine inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Ephedrine inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; yupingfeng inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; yupingfeng inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]
Bleomycin results in decreased expression of ACTA2 protein
allyl sulfide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; andrographolide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; montelukast inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; pachymic acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of and results in increased phosphorylation of ACTA2 protein]; 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]]; [Arsenic Trioxide co-treated with Bleomycin] results in decreased expression of ACTA2 mRNA; [Bleomycin co-treated with Soot] results in increased expression of ACTA2 protein; Bleomycin results in increased expression of and results in increased phosphorylation of ACTA2 protein; Calcitriol inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; CCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; celastrol inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of and results in increased phosphorylation of ACTA2 protein]; Diazoxide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; honokiol inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; icaritin inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; lenabasum inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; loganin inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; loganin inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; MIR100HG mRNA affects the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; MIR100HG mRNA affects the reaction [Bleomycin results in increased expression of ACTA2 protein]; morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]

PMID:14609568 PMID:17177178 PMID:21381050 PMID:23656969 PMID:24762191 More...

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, gamma 1

increases expression

Bleomycin results in increased expression of ACTG1 mRNA

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

G

actinin, alpha 1

decreases expression

Bleomycin results in decreased expression of ACTN1 protein

NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251

G

actinin alpha 4

decreases expression

Bleomycin results in decreased expression of ACTN4 protein

NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847

G

actin related protein 10

increases expression

Bleomycin results in increased expression of ACTR10 mRNA

NCBI chr 6:89,446,141...89,472,350
Ensembl chr 6:89,446,093...89,473,047

G

actin related protein 3B

increases expression

Bleomycin results in increased expression of ACTR3B mRNA

NCBI chr 4:9,261,631...9,355,496
Ensembl chr 4:9,262,233...9,355,441

G

ADAM metallopeptidase domain 17

multiple interactions

Bleomycin results in increased expression of and results in increased activity of ADAM17 protein

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

adrenoceptor alpha 1B

decreases expression

Bleomycin results in decreased expression of ADRA1B mRNA

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

G

advanced glycosylation end product-specific receptor

multiple interactions
decreases expression

protocatechualdehyde inhibits the reaction [Bleomycin results in decreased expression of AGER protein]

PMID:25582705 PMID:25933445

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

angiotensin II receptor, type 1a

multiple interactions
increases expression

angiotensin I (1-7) inhibits the reaction [Bleomycin results in increased expression of AGTR1 protein]

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

alpha-2-HS-glycoprotein

increases expression

Bleomycin results in increased expression of AHSG protein

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin affects the expression of and affects the localization of AIFM1 protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin affects the expression of and affects the localization of AIFM1 protein]]; baicalein inhibits the reaction [Bleomycin affects the expression of and affects the localization of AIFM1 protein]; Bleomycin affects the expression of and affects the localization of AIFM1 protein; Diazoxide inhibits the reaction [Bleomycin affects the expression of and affects the localization of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

increases phosphorylation

Bleomycin results in increased phosphorylation of AKT1 protein

PMID:22687607 PMID:26520185

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

increases expression

Bleomycin results in increased expression of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

decreases expression

Bleomycin results in decreased expression of ALDH1A1 protein

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldolase, fructose-bisphosphate C

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ALDOC protein

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

angiopoietin-like 3

increases expression
multiple interactions

Bleomycin results in increased expression of ANGPTL3 protein
Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of ANGPTL3 protein]; lenabasum inhibits the reaction [Bleomycin results in increased expression of ANGPTL3 protein]

NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957

G

ankyrin repeat domain 1

increases expression

Bleomycin results in increased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

G

acidic nuclear phosphoprotein 32 family member E

increases expression

Bleomycin results in increased expression of ANP32E protein

NCBI chr 2:183,472,600...183,489,057
Ensembl chr 2:183,472,609...183,489,054

G

annexin A2

decreases expression

Bleomycin results in decreased expression of ANXA2 protein

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

annexin A3

decreases expression

Bleomycin results in decreased expression of ANXA3 protein

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

annexin A4

decreases expression

Bleomycin results in decreased expression of ANXA4 protein

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

annexin A5

increases expression

Bleomycin results in increased expression of ANXA5 protein

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

annexin A6

decreases expression

Bleomycin results in decreased expression of ANXA6 protein

NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433

G

annexin A7

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ANXA7 protein

NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385

G

aquaporin 1

decreases expression

Bleomycin results in decreased expression of AQP1 mRNA

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

amphiregulin

increases expression

Bleomycin results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

arginase 1

increases expression
multiple interactions
decreases expression

Bleomycin results in increased expression of ARG1 mRNA; Bleomycin results in increased expression of ARG1 protein
Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of ARG1 protein]

PMID:26345256 PMID:26526764 PMID:30825431 PMID:33647319

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

activating transcription factor 4

multiple interactions
increases expression

pachymic acid inhibits the reaction [Bleomycin results in increased expression of ATF4 protein]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

ATM serine/threonine kinase

multiple interactions
increases phosphorylation

2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Bleomycin promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Bleomycin results in increased phosphorylation of ATM protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Bleomycin results in increased phosphorylation of ATM protein]]; Bleomycin promotes the reaction [resveratrol results in increased phosphorylation of ATM protein]; resveratrol promotes the reaction [Bleomycin results in increased phosphorylation of ATM protein]

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATP synthase F1 subunit beta

decreases expression

Bleomycin results in decreased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase inhibitory factor subunit 1

increases expression

Bleomycin results in increased expression of ATP5IF1 protein

NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668

G

ATP synthase membrane subunit e

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in increased expression of ATP5ME protein

NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013

G

ATP synthase peripheral stalk subunit OSCP

decreases expression

Bleomycin results in decreased expression of ATP5PO protein

NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592

G

ATPase H+ transporting V1 subunit A

multiple interactions
decreases expression

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ATP6V1A protein
Bleomycin results in decreased expression of ATP6V1A protein

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

arginine vasopressin receptor 1A

decreases expression

Bleomycin results in decreased expression of AVPR1A mRNA

NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215

G

brain abundant, membrane attached signal protein 1

increases expression

Bleomycin results in increased expression of BASP1 protein

NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

allyl sulfide inhibits the reaction [Bleomycin results in increased expression of BAX protein]; Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of BAX mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of BAX mRNA]
5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased expression of BAX protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in increased expression of BAX protein]]; baicalein inhibits the reaction [Bleomycin results in increased expression of BAX protein]; Bleomycin inhibits the reaction [Azacitidine results in increased expression of BAX mRNA]; Diazoxide inhibits the reaction [Bleomycin results in increased expression of BAX protein]
Bleomycin results in increased expression of BAX mRNA; Bleomycin results in increased expression of BAX protein

PMID:23656969 PMID:26093215 PMID:32278510 PMID:37783230

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression
increases expression

[Bleomycin co-treated with Bee Venoms] results in decreased expression of BCL2 mRNA; allyl sulfide promotes the reaction [Bleomycin results in increased expression of BCL2 protein]; Phytochemicals inhibits the reaction [Bleomycin results in decreased expression of BCL2 mRNA]
Bleomycin results in decreased expression of BCL2 protein
5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]]; baicalein inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]; Bleomycin inhibits the reaction [Azacitidine results in decreased expression of BCL2 mRNA]; Bleomycin inhibits the reaction [Azacitidine results in decreased expression of BCL2 protein]; Diazoxide inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]
[Polyphenols co-treated with Bleomycin] results in increased expression of BCL2 mRNA; [Tea co-treated with Bleomycin] results in increased expression of BCL2 mRNA

PMID:23656969 PMID:24822179 PMID:26093215 PMID:26800624 PMID:32278510 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

thymoquinone inhibits the reaction [Bleomycin results in decreased expression of BCL2L1 mRNA]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BCL6B, transcription repressor

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of BCL6B mRNA

NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974

G

BCL2-interacting killer

increases expression

Bleomycin results in increased expression of BIK mRNA

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

baculoviral IAP repeat-containing 2

decreases response to substance
increases expression

BIRC2 protein results in decreased susceptibility to Bleomycin
Bleomycin results in increased expression of BIRC2 protein

PMID:10815900 PMID:15371238

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 5

increases expression

Bleomycin results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bleomycin hydrolase

affects response to substance

BLMH gene polymorphism affects the susceptibility to Bleomycin

NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212

G

bone morphogenetic protein 7

decreases expression

Bleomycin results in decreased expression of BMP7 mRNA

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

BSCL2 lipid droplet biogenesis associated, seipin

increases expression

Bleomycin results in increased expression of BSCL2 mRNA

NCBI chr 1:205,731,828...205,743,430
Ensembl chr 1:205,733,872...205,743,421

G

complement C1q B chain

increases expression

Bleomycin results in increased expression of C1QB mRNA

NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407

G

calcitonin-related polypeptide alpha

increases expression

Bleomycin results in increased expression of CALCA mRNA

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

caldesmon 1

increases expression

Bleomycin results in increased expression of CALD1 protein

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calmodulin-like 3

decreases expression

Bleomycin results in decreased expression of CALML3 protein

NCBI chr17:66,419,844...66,423,083
Ensembl chr17:66,419,882...66,423,175

G

calreticulin

increases expression

Bleomycin results in increased expression of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calumenin

increases expression

Bleomycin results in increased expression of CALU protein

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

carbonic anhydrase 1

decreases expression

Bleomycin results in decreased expression of CA1 protein

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 2

decreases expression

Bleomycin results in decreased expression of CA2 protein

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

calcium regulated heat stable protein 1

increases expression

Bleomycin results in increased expression of CARHSP1 protein

NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019

G

caspase 3

multiple interactions
increases cleavage
increases expression
increases activity

[Bleomycin co-treated with Bee Venoms] results in increased expression of CASP3 mRNA; allyl sulfide inhibits the reaction [Bleomycin results in increased expression of CASP3 protein]; Bleomycin results in increased cleavage of and results in increased activity of CASP3 protein; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of CASP3 mRNA]
Bleomycin results in increased cleavage of CASP3 protein
5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased cleavage of CASP3 protein]]; baicalein inhibits the reaction [Bleomycin results in increased cleavage of CASP3 protein]
[Polyphenols co-treated with Bleomycin] results in increased expression of CASP3 mRNA; [Tea co-treated with Bleomycin] results in increased expression of CASP3 mRNA
Bleomycin results in increased expression of CASP3 mRNA; Bleomycin results in increased expression of CASP3 protein
Bleomycin results in increased activity of CASP3 protein

PMID:15371238 PMID:22687607 PMID:23656969 PMID:24822179 PMID:26093215 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

[Polyphenols co-treated with Bleomycin] results in increased expression of CASP8 mRNA; [Tea co-treated with Bleomycin] results in increased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases expression
increases activity

Bleomycin results in increased cleavage of and results in increased activity of CASP9 protein; pachymic acid inhibits the reaction [Bleomycin results in increased expression of CASP9 protein]
[Polyphenols co-treated with Bleomycin] results in increased expression of CASP9 mRNA; [Tea co-treated with Bleomycin] results in increased expression of CASP9 mRNA
Bleomycin results in increased activity of CASP9 protein

PMID:15371238 PMID:22687607 PMID:26800624 PMID:37163307

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calpastatin

increases expression

Bleomycin results in increased expression of CAST protein

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

G

catalase

increases response to substance
decreases activity
multiple interactions
increases expression

CAT protein results in increased susceptibility to Bleomycin
Bleomycin results in decreased activity of CAT
celastrol inhibits the reaction [Bleomycin results in decreased activity of CAT protein]; pachymic acid inhibits the reaction [Bleomycin results in decreased activity of CAT protein]
IL1A protein promotes the reaction [Bleomycin results in increased expression of CAT protein]; IL1B protein promotes the reaction [Bleomycin results in increased expression of CAT protein]; TNF protein promotes the reaction [Bleomycin results in increased expression of CAT protein]
Bleomycin results in decreased expression of and results in decreased activity of CAT protein; caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of CAT protein]; Oils, Volatile inhibits the reaction [Bleomycin results in decreased activity of CAT protein]

PMID:8317554 PMID:10751631 PMID:23570914 PMID:26768587 PMID:28850077 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

decreases expression
multiple interactions

Bleomycin results in decreased expression of CAV1 protein
yupingfeng inhibits the reaction [Bleomycin results in decreased expression of CAV1 mRNA]; yupingfeng inhibits the reaction [Bleomycin results in decreased expression of CAV1 protein]
Bleomycin results in decreased expression of CAV1 mRNA; Bleomycin results in decreased expression of CAV1 protein

PMID:25933445 PMID:37898439

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

caveolae associated protein 2

decreases expression

Bleomycin results in decreased expression of CAVIN2 protein

NCBI chr 9:50,302,079...50,314,096
Ensembl chr 9:50,301,206...50,314,147

G

chromobox 8

decreases expression
multiple interactions

Bleomycin results in decreased expression of CBX8 mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of CBX8 mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of CBX8 mRNA]

NCBI chr10:104,294,518...104,296,956
Ensembl chr10:104,294,518...104,297,024

G

cholecystokinin A receptor

decreases expression

Bleomycin results in decreased expression of CCKAR mRNA

NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747

G

C-C motif chemokine ligand 11

increases expression
decreases expression
multiple interactions
decreases response to substance

Bleomycin results in increased expression of CCL11 mRNA; Bleomycin results in increased expression of CCL11 protein
Bleomycin results in decreased expression of CCL11 mRNA
CCL11 protein promotes the reaction [Bleomycin results in increased expression of CCL2 mRNA]; CCL11 protein promotes the reaction [Bleomycin results in increased expression of TGFB1 mRNA]
CCL11 gene mutant form results in decreased susceptibility to Bleomycin

PMID:16314464 PMID:29720568

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 12

increases expression
decreases expression
multiple interactions

Bleomycin results in increased expression of CCL12 mRNA
Bleomycin results in decreased expression of CCL12 mRNA
[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; CCL12 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of CCL12 mRNA]

PMID:28434932 PMID:29720568

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

G

C-C motif chemokine ligand 17

increases expression

Bleomycin results in increased expression of CCL17 mRNA; Bleomycin results in increased expression of CCL17 protein

PMID:26345256 PMID:29175452

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 2

increases expression
multiple interactions
decreases expression

Bleomycin results in increased expression of CCL2 mRNA; Bleomycin results in increased expression of CCL2 protein
[Bleomycin co-treated with Tobacco Smoke Pollution] results in increased expression of CCL2 protein
Bleomycin results in decreased expression of CCL2 mRNA
Calcitriol inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; CCL11 protein promotes the reaction [Bleomycin results in increased expression of CCL2 mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of CCL2 mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; Rosiglitazone inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]; SPL-334 inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]

PMID:15541506 PMID:16314464 PMID:17177178 PMID:19147827 PMID:26209236 More...

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

increases expression
decreases expression
multiple interactions

Bleomycin results in increased expression of CCL3 mRNA
Bleomycin results in decreased expression of CCL3 protein
[Bleomycin co-treated with Tobacco Smoke Pollution] affects the expression of CCL3 protein
Bleomycin results in decreased expression of CCL3 mRNA
Calcitriol inhibits the reaction [Bleomycin results in increased expression of CCL3 mRNA]

PMID:26520185 PMID:29720568 PMID:32828905 PMID:33516805

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

decreases expression

Bleomycin results in decreased expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

increases expression
multiple interactions

Bleomycin results in increased expression of CCL5 mRNA
SLCO2A1 gene mutant form promotes the reaction [Bleomycin results in increased expression of CCL5 mRNA]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

decreases expression

Bleomycin results in decreased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine ligand 9

increases expression

Bleomycin results in increased expression of CCL6 protein

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cellular communication network factor 2

multiple interactions
increases expression

[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; honokiol inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]; lenabasum inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]; OGG1 protein affects the reaction [Bleomycin results in increased expression of CCN2 protein]; OGG1 protein inhibits the reaction [TH5487 inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]]; OGG1 protein promotes the reaction [Bleomycin results in increased expression of CCN2 protein]; pirfenidone inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of CCN2 mRNA]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]; TH5487 inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]
Bleomycin results in increased expression of CCN2 mRNA; Bleomycin results in increased expression of CCN2 protein

PMID:19080365 PMID:26817844 PMID:27153807 PMID:28434932 PMID:32032644 More...

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin G1

increases expression

Bleomycin results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

C-C motif chemokine receptor 2

multiple interactions
increases expression
decreases response to substance

CCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; CCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; CCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; CCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]
Bleomycin results in increased expression of CCR2 mRNA
CCR2 gene mutant form results in decreased susceptibility to Bleomycin

PMID:14609568 PMID:29033951

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 3

increases expression

Bleomycin results in increased expression of CCR3 mRNA; Bleomycin results in increased expression of CCR3 protein

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

C-C motif chemokine receptor 5

affects expression
multiple interactions
increases expression

Bleomycin affects the expression of CCR5 mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of CCR5 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of CCR5 mRNA]

PMID:26345256 PMID:30825431

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

chaperonin containing TCP1 subunit 8

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of CCT8 protein

NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079

G

CD14 molecule

increases expression

Bleomycin results in increased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

Cd2 molecule

increases expression

Bleomycin results in increased expression of CD2 mRNA

NCBI chr 2:188,710,895...188,724,044
Ensembl chr 2:188,710,900...188,724,026

G

CD33 molecule

increases expression
multiple interactions

Bleomycin results in increased expression of CD33 mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of CD33 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of CD33 mRNA]

NCBI chr 1:93,935,418...93,940,452
Ensembl chr 1:93,930,971...93,950,149

G

CD34 molecule

multiple interactions
decreases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of CD34 protein]

NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832

G

CD36 molecule

decreases expression

Bleomycin results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD44 molecule

multiple interactions
increases expression

honokiol inhibits the reaction [Bleomycin results in increased expression of CD44 protein]

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

CD83 molecule

increases expression

Bleomycin results in increased expression of CD83 mRNA

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

G

CD86 molecule

decreases expression

Bleomycin results in decreased expression of CD86 mRNA

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cell division cycle 20

increases expression

Bleomycin results in increased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cadherin 1

multiple interactions
decreases expression

12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]; Dexamethasone inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]; geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]; Grape Seed Extract inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; Grape Seed Extract inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]; honokiol inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]; MIR100HG mRNA affects the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; MIR100HG mRNA affects the reaction [Bleomycin results in decreased expression of CDH1 protein]; OGG1 protein affects the reaction [Bleomycin results in decreased expression of CDH1 protein]; OGG1 protein inhibits the reaction [TH5487 inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]]; pirfenidone inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]; TH5487 inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]
Ephedrine inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; Ephedrine inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]
Bleomycin results in decreased expression of CDH1 mRNA; Bleomycin results in decreased expression of CDH1 protein

PMID:28300665 PMID:28694203 PMID:32032644 PMID:34425168 PMID:35472619 More...

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

increases expression
multiple interactions

Bleomycin results in increased expression of CDH2 protein
OGG1 protein affects the reaction [Bleomycin results in increased expression of CDH2 protein]; OGG1 protein inhibits the reaction [TH5487 inhibits the reaction [Bleomycin results in increased expression of CDH2 protein]]; pirfenidone inhibits the reaction [Bleomycin results in increased expression of CDH2 protein]; TH5487 inhibits the reaction [Bleomycin results in increased expression of CDH2 protein]

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase inhibitor 1A

increases expression

Bleomycin results in increased expression of CDKN1A mRNA

PMID:26345256 PMID:29720568 PMID:32554301

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CCAAT/enhancer binding protein beta

increases expression
increases response to substance
multiple interactions
decreases response to substance

Bleomycin results in increased expression of CEBPB mRNA
CEBPB protein results in increased susceptibility to Bleomycin
CEBPB protein affects the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of CCL2 mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of IL1B mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of TNF mRNA]
CEBPB gene mutant form results in decreased susceptibility to Bleomycin

PMID:17177178 PMID:21998664

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

cell migration inducing hyaluronidase 2

decreases expression

Bleomycin results in decreased expression of CEMIP2 mRNA

NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760

G

centromere protein E

multiple interactions
decreases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of CENPE mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of CENPE mRNA]

NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669

G

ceramide transporter 1

increases expression

Bleomycin results in increased expression of CERT1 mRNA

NCBI chr 2:27,882,546...27,987,090
Ensembl chr 2:27,882,555...27,987,074

G

carboxylesterase 1D

decreases expression

Bleomycin results in decreased expression of CES1 protein

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

cofilin 1

increases expression

Bleomycin results in increased expression of CFL1 protein

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

checkpoint kinase 2

increases phosphorylation
multiple interactions

Bleomycin results in increased phosphorylation of CHEK2 protein
resveratrol promotes the reaction [Bleomycin results in increased phosphorylation of CHEK2 protein]

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

cholinergic receptor nicotinic beta 2 subunit

decreases expression

Bleomycin results in decreased expression of CHRNB2 mRNA

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

creatine kinase B

increases expression

Bleomycin results in increased expression of CKB protein

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

chloride voltage-gated channel 5

increases expression

Bleomycin results in increased expression of CLCN5 mRNA

NCBI chr X:15,185,380...15,339,977
Ensembl chr X:15,185,451...15,334,264

G

claudin 4

increases expression

Bleomycin results in increased expression of CLDN4 mRNA

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

chloride intracellular channel 4

decreases expression

Bleomycin results in decreased expression of CLIC4 protein

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

chloride intracellular channel 5

decreases expression

Bleomycin results in decreased expression of CLIC5 protein

NCBI chr 9:16,710,980...16,813,502
Ensembl chr 9:16,710,980...16,813,427

G

clathrin heavy chain

decreases expression

Bleomycin results in decreased expression of CLTC protein

NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737

G

cannabinoid receptor 1

decreases expression

Bleomycin results in decreased expression of CNR1 mRNA

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

collagen type XI alpha 2 chain

increases expression

Bleomycin results in increased expression of COL11A2 mRNA

NCBI chr20:4,786,932...4,816,598
Ensembl chr20:4,786,929...4,815,985

G

collagen type XIV alpha 1 chain

increases expression

Bleomycin results in increased expression of COL14A1 mRNA

NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214

G

collagen type XVIII alpha 1 chain

increases expression

Bleomycin results in increased expression of COL18A1 mRNA

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

collagen type I alpha 1 chain

multiple interactions
increases expression
decreases expression

5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]]; [Bleomycin co-treated with Soot] results in increased expression of COL1A1 protein; Arsenic Trioxide inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Arsenic Trioxide inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; baicalein inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; CCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Diazoxide inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Enalapril inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Grape Seed Extract inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Grape Seed Extract inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; icaritin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Rosiglitazone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; S1PR5 protein affects the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]
MIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]
Bleomycin results in increased expression of COL1A1 mRNA; Bleomycin results in increased expression of COL1A1 protein
Bleomycin results in decreased expression of COL1A1 protein
Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Hydrocortisone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Hydrocortisone inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]

PMID:12003776 PMID:14609568 PMID:17434272 PMID:19147827 PMID:24762191 More...

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

increases expression
multiple interactions
decreases expression

Bleomycin results in increased expression of COL1A2 mRNA; Bleomycin results in increased expression of COL1A2 protein
pachymic acid inhibits the reaction [Bleomycin results in increased expression of COL1A2 protein]
Bleomycin results in decreased expression of COL1A2 protein
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 protein]; MIR100HG mRNA affects the reaction [Bleomycin results in increased expression of COL1A2 protein]; Rosiglitazone inhibits the reaction [Bleomycin results in increased expression of COL1A2 mRNA]

PMID:19147827 PMID:25933445 PMID:35472619 PMID:37163307 PMID:37307957

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type XXII alpha 1 chain

increases expression

Bleomycin results in increased expression of COL22A1 mRNA

NCBI chr 7:103,730,939...103,968,452
Ensembl chr 7:103,731,037...103,968,462

G

collagen type XXIV alpha 1 chain

increases expression

Bleomycin results in increased expression of COL24A1 mRNA

NCBI chr 2:234,212,256...234,469,445
Ensembl chr 2:234,212,324...234,469,441

G

collagen type III alpha 1 chain

decreases expression
multiple interactions
increases expression

Bleomycin results in decreased expression of COL3A1 protein
honokiol inhibits the reaction [Bleomycin results in increased expression of COL3A1 protein]
MIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of COL3A1 mRNA]
Bleomycin results in increased expression of COL3A1 mRNA; Bleomycin results in increased expression of COL3A1 protein

PMID:25933445 PMID:26817844 PMID:28726637 PMID:32032644

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 4 chain

increases expression

Bleomycin results in increased expression of COL4A4 mRNA

NCBI chr 9:83,833,173...83,875,436
Ensembl chr 9:83,755,515...83,875,876

G

collagen type V alpha 1 chain

decreases expression
increases expression

Bleomycin results in decreased expression of COL5A1 protein
Bleomycin results in increased expression of COL5A1 mRNA

PMID:25933445 PMID:36087614

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

collagen type V alpha 2 chain

increases expression

Bleomycin results in increased expression of COL5A2 mRNA

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

collagen type V alpha 3 chain

increases expression

Bleomycin results in increased expression of COL5A3 mRNA

NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853

G

collagen type VI alpha 3 chain

increases expression

Bleomycin results in increased expression of COL6A3 mRNA

NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471

G

collagen type IX alpha 2 chain

increases expression

Bleomycin results in increased expression of COL9A2 mRNA

NCBI chr 5:134,607,616...134,624,678
Ensembl chr 5:134,607,616...134,624,677

G

collagen like tail subunit of asymmetric acetylcholinesterase

increases expression

Bleomycin results in increased expression of COLQ mRNA

NCBI chr16:6,731,850...6,824,973
Ensembl chr16:6,731,858...6,787,107

G

cartilage oligomeric matrix protein

multiple interactions

[S1PR5 protein affects the susceptibility to Bleomycin] which affects the expression of COMP protein

NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845

G

ceruloplasmin

multiple interactions
increases expression

tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CP protein]

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

cysteine-rich protein 2

affects expression

Bleomycin affects the expression of CRIP2 protein

NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065

G

colony stimulating factor 2

increases expression
multiple interactions
decreases expression

Bleomycin results in increased expression of CSF2 mRNA; Bleomycin results in increased expression of CSF2 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Bleomycin results in increased expression of CSF2 mRNA]; Apigenin inhibits the reaction [Bleomycin results in increased expression of CSF2 mRNA]
Bleomycin results in decreased expression of CSF2 mRNA

PMID:18684396 PMID:29720568 PMID:32554301

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 2 receptor subunit beta

increases expression

Bleomycin results in increased expression of CSF2RB2 mRNA

NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157

G

colony stimulating factor 3

decreases expression

Bleomycin results in decreased expression of CSF3 mRNA

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

cysteine and glycine-rich protein 1

increases expression

Bleomycin results in increased expression of CSRP1 protein

NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384

G

cathepsin A

affects expression

Bleomycin affects the expression of CTSA mRNA

NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215

G

cathepsin B

affects expression

Bleomycin affects the expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin H

affects expression

Bleomycin affects the expression of CTSH mRNA

NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824

G

cathepsin S

increases expression

Bleomycin results in increased expression of CTSS mRNA

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

C-X3-C motif chemokine ligand 1

increases expression
multiple interactions

Bleomycin results in increased expression of CX3CL1 protein
Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of CX3CL1 protein]; lenabasum inhibits the reaction [Bleomycin results in increased expression of CX3CL1 protein]

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 1

multiple interactions
increases expression

5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Bleomycin results in increased expression of CXCL1 mRNA]; Apigenin inhibits the reaction [Bleomycin results in increased expression of CXCL1 mRNA]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

increases expression
multiple interactions
decreases expression

Bleomycin results in increased expression of CXCL10 mRNA; Bleomycin results in increased expression of CXCL10 protein
[Bleomycin co-treated with Tobacco Smoke Pollution] results in increased expression of CXCL10 protein
Bleomycin results in decreased expression of CXCL10 mRNA

PMID:26345256 PMID:29720568 PMID:33516805 PMID:36087614

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

increases expression

Bleomycin results in increased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 13

affects expression

Bleomycin affects the expression of CXCL13 mRNA

NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933

G

C-X-C motif chemokine ligand 14

increases expression

Bleomycin results in increased expression of CXCL14 mRNA

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

C-X-C motif chemokine ligand 2

increases expression
multiple interactions
increases secretion

Bleomycin results in increased expression of CXCL2 protein
[Bleomycin co-treated with Tobacco Smoke Pollution] results in increased expression of CXCL2 protein
3-aminobenzamide inhibits the reaction [Bleomycin results in increased secretion of CXCL2 protein]; Calcitriol inhibits the reaction [Bleomycin results in increased expression of CXCL2 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Bleomycin results in increased secretion of CXCL2 protein]; TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of CXCL2 protein]

PMID:18684396 PMID:22687607 PMID:26520185 PMID:26600069 PMID:33516805

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions
increases expression
increases secretion

TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of CXCL1 protein]
Bleomycin results in increased expression of CXCL1 mRNA
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Bleomycin results in increased expression of CXCL1 mRNA]; Apigenin inhibits the reaction [Bleomycin results in increased expression of CXCL1 mRNA]
Bleomycin results in increased expression of CXCL1 protein

PMID:26600069 PMID:32554301 PMID:36087614

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 9

increases expression

Bleomycin results in increased expression of CXCL9 protein

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

C-X-C motif chemokine receptor 1

increases expression

Bleomycin results in increased expression of CXCR1 mRNA

NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084

G

cytochrome b-245 alpha chain

multiple interactions
increases expression

Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA]

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome c, somatic

affects localization

Bleomycin affects the localization of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

diazepam binding inhibitor

increases expression

Bleomycin results in increased expression of DBI protein

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

Bleomycin results in increased expression of DDIT3 protein
pachymic acid inhibits the reaction [Bleomycin results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

desmin

increases expression

Bleomycin results in increased expression of DES protein

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

dihydrolipoamide S-acetyltransferase

decreases expression

Bleomycin results in decreased expression of DLAT protein

NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479

G

dihydrolipoamide dehydrogenase

increases expression

Bleomycin results in increased expression of DLD protein

PMID:25933445 PMID:29733421

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

G

delta like non-canonical Notch ligand 1

increases expression

Bleomycin results in increased expression of DLK1 protein

NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522

G

delta like canonical Notch ligand 4

multiple interactions
decreases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of DLL4 protein]; lenabasum promotes the reaction [Bleomycin results in decreased expression of DLL4 protein]

NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931

G

dynamin 1-like

increases expression

Bleomycin results in increased expression of DNM1L protein

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

DNA methyltransferase 1

affects response to substance

DNMT1 protein affects the susceptibility to Bleomycin

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dipeptidase 1

decreases expression

Bleomycin results in decreased expression of DPEP1 protein

NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257

G

enoyl-CoA hydratase 1

decreases expression

Bleomycin results in decreased expression of ECH1 protein

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795

G

endothelin 1

multiple interactions
increases expression

Phytochemicals inhibits the reaction [Bleomycin results in increased expression of EDN1 mRNA]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation elongation factor 1 alpha 1

increases expression

Bleomycin results in increased expression of EEF1A1 protein

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

G

early growth response 1

increases expression
affects expression
multiple interactions

Bleomycin results in increased expression of EGR1 mRNA
Bleomycin affects the expression of EGR1 mRNA
rosiglitazone inhibits the reaction [Bleomycin results in increased expression of EGR1 mRNA]

PMID:19147827 PMID:26345256

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

affects expression

Bleomycin affects the expression of EGR2 mRNA

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

EH-domain containing 1

decreases expression

Bleomycin results in decreased expression of EHD1 protein

NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212

G

EH-domain containing 2

decreases expression

Bleomycin results in decreased expression of EHD2 protein

NCBI chr 1:76,639,568...76,658,747
Ensembl chr 1:76,637,482...76,658,783

G

eukaryotic translation initiation factor 5A

increases expression

Bleomycin results in increased expression of EIF5A protein

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

elastin

increases expression

Bleomycin results in increased expression of ELN mRNA

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

endomucin

increases expression
multiple interactions

Bleomycin results in increased expression of EMCN mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of EMCN mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of EMCN mRNA]

NCBI chr 2:225,891,100...225,970,932
Ensembl chr 2:225,891,100...225,970,929

G

endoglin

multiple interactions
increases expression

Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of ENG protein]

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

eosinophil peroxidase

increases expression

Bleomycin results in increased expression of EPX protein

NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952

G

ERBB receptor feedback inhibitor 1

decreases expression

Bleomycin results in decreased expression of ERRFI1 mRNA

NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282

G

extra spindle pole bodies like 1, separase

multiple interactions
decreases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of ESPL1 mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of ESPL1 mRNA]

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

G

ETS proto-oncogene 1, transcription factor

decreases expression

Bleomycin results in decreased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

ETS proto-oncogene 2, transcription factor

decreases expression

Bleomycin results in decreased expression of ETS2 mRNA

NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319

G

ezrin

decreases expression

Bleomycin results in decreased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

F2R like trypsin receptor 1

multiple interactions
increases expression

allyl sulfide inhibits the reaction [Bleomycin results in increased expression of F2RL1 mRNA]; allyl sulfide inhibits the reaction [Bleomycin results in increased expression of F2RL1 protein]
Bleomycin results in increased expression of F2RL1 mRNA; Bleomycin results in increased expression of F2RL1 protein

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

fatty acid binding protein 4

decreases expression

Bleomycin results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

Fas ligand

increases expression

Bleomycin results in increased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibroblast growth factor 1

increases expression
multiple interactions

Bleomycin results in increased expression of FGF1 protein
Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of FGF1 protein]

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 2

increases expression
multiple interactions

Bleomycin results in increased expression of FGF2 protein
Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of FGF2 protein]
protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of FGF2 protein]

PMID:25582705 PMID:30825431

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 21

decreases expression
multiple interactions

Bleomycin results in decreased expression of FGF21 protein
Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of FGF21 protein]

NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454

G

fibroblast growth factor 7

increases expression
multiple interactions

Bleomycin results in increased expression of FGF7 protein
Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of FGF7 protein]; lenabasum inhibits the reaction [Bleomycin results in increased expression of FGF7 protein]

NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929

G

four and a half LIM domains 1

increases expression

Bleomycin results in increased expression of FHL1 protein

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

FKBP prolyl isomerase 10

increases expression

Bleomycin results in increased expression of FKBP10 mRNA

NCBI chr10:85,345,434...85,357,998
Ensembl chr10:85,346,126...85,427,330

G

fibronectin 1

increases expression
multiple interactions

Bleomycin results in increased expression of FN1 protein
pachymic acid inhibits the reaction [Bleomycin results in increased expression of FN1 protein]
Bleomycin results in increased expression of FN1 mRNA
Bleomycin results in increased expression of FN1 mRNA; Bleomycin results in increased expression of FN1 protein
[Bleomycin co-treated with Soot] results in increased expression of FN1 protein; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of FN1 protein]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 protein]; Grape Seed Extract inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]; Grape Seed Extract inhibits the reaction [Bleomycin results in increased expression of FN1 protein]; honokiol inhibits the reaction [Bleomycin results in increased expression of FN1 protein]; OGG1 protein affects the reaction [Bleomycin results in increased expression of FN1 protein]; OGG1 protein inhibits the reaction [TH5487 inhibits the reaction [Bleomycin results in increased expression of FN1 protein]]; OGG1 protein promotes the reaction [Bleomycin results in increased expression of FN1 protein]; pirfenidone inhibits the reaction [Bleomycin results in increased expression of FN1 protein]; Soot promotes the reaction [Bleomycin results in increased expression of FN1 mRNA]; TH5487 inhibits the reaction [Bleomycin results in increased expression of FN1 protein]; Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]

PMID:25071917 PMID:25933445 PMID:26345256 PMID:26817844 PMID:28300665 More...

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases activity
multiple interactions

Bleomycin results in increased activity of FOS protein
Bleomycin results in increased expression of [JUN protein binds to FOS protein]

PMID:12003776 PMID:37399107

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box P3

increases expression

Bleomycin results in increased expression of FOXP3 mRNA

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

forkhead box Q1

increases expression

Bleomycin results in increased expression of FOXQ1 mRNA

NCBI chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377

G

forkhead box R1

increases expression

Bleomycin results in increased expression of FOXR1 mRNA

NCBI chr 8:44,760,587...44,768,696
Ensembl chr 8:44,760,948...44,768,880

G

follicle stimulating hormone subunit beta

increases expression
multiple interactions

Bleomycin results in increased expression of FSHB protein
thymoquinone inhibits the reaction [Bleomycin results in increased expression of FSHB protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

follicle stimulating hormone receptor

decreases expression

Bleomycin results in decreased expression of FSHR mRNA

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

far upstream element binding protein 1

increases expression

Bleomycin results in increased expression of FUBP1 protein

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

frizzled class receptor 6

increases expression
multiple interactions

Bleomycin results in increased expression of FZD6 mRNA
MIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of FZD6 mRNA]

NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776

G

gamma-aminobutyric acid type A receptor subunit alpha 4

decreases expression

Bleomycin results in decreased expression of GABRA4 mRNA

NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit beta 2

decreases expression

Bleomycin results in decreased expression of GABRB2 mRNA

NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit gamma 2

decreases expression

Bleomycin results in decreased expression of GABRG2 mRNA

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

gamma-aminobutyric acid type A receptor subunit rho 1

decreases expression

Bleomycin results in decreased expression of GABRR1 mRNA

NCBI chr 5:47,524,151...47,561,228
Ensembl chr 5:47,524,151...47,561,228

G

glucosidase II alpha subunit

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of GANAB protein

NCBI chr 1:205,793,910...205,813,704
Ensembl chr 1:205,793,895...205,813,695

G

growth arrest specific 6

increases expression

Bleomycin results in increased expression of GAS6 protein

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

GATA binding protein 3

increases expression
multiple interactions

Bleomycin results in increased expression of GATA3 mRNA
S1PR5 protein affects the reaction [Bleomycin results in increased expression of GATA3 mRNA]

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

GC, vitamin D binding protein

increases expression

Bleomycin results in increased expression of GC protein

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
decreases expression

caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of GCLC protein]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

guanine deaminase

decreases expression

Bleomycin results in decreased expression of GDA protein

NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416

G

galactosidase, beta 1

increases activity

Bleomycin results in increased activity of GLB1 protein

NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127

G

glucose-6-phosphate isomerase

decreases expression

Bleomycin results in decreased expression of GPI protein

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

glutathione peroxidase 1

affects expression

Bleomycin affects the expression of GPX1 protein

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutamate ionotropic receptor AMPA type subunit 2

decreases expression

Bleomycin results in decreased expression of GRIA2 mRNA

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

glutamate ionotropic receptor kainate type subunit 3

decreases expression

Bleomycin results in decreased expression of GRIK3 mRNA

NCBI chr 5:137,767,865...137,989,617
Ensembl chr 5:137,767,865...137,984,307

G

gastrin releasing peptide receptor

decreases expression

Bleomycin results in decreased expression of GRPR mRNA

NCBI chr X:30,998,425...31,038,442
Ensembl chr X:30,998,416...31,038,442

G

glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein] which results in decreased susceptibility to Bleomycin; [Bleomycin results in increased phosphorylation of GSK3B protein] inhibits the reaction [GSK3B protein binds to and results in increased stability of NFKBIA protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

decreases expression

Bleomycin results in decreased expression of GSN protein

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione-disulfide reductase

decreases activity
multiple interactions

Bleomycin results in decreased activity of GSR protein
celastrol inhibits the reaction [Bleomycin results in decreased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

decreases expression

Bleomycin results in decreased expression of GSTM1 protein

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

H1.0 linker histone

affects expression

Bleomycin affects the expression of H1F0 protein

NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694

G

H1.4 linker histone, cluster member

affects expression

Bleomycin affects the expression of H1F4 protein

NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403

G

H2A.X variant histone

increases expression

Bleomycin results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

decreases expression

Bleomycin results in decreased expression of HADHA protein

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

G

hepatitis A virus cellular receptor 1

increases expression

Bleomycin results in increased expression of HAVCR1 protein

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

hemoglobin subunit beta

affects expression

Bleomycin affects the expression of HBB protein

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

hemoglobin, beta adult minor chain

affects expression

Bleomycin affects the expression of HBB-B2 protein

NCBI chr 1:158,243,696...158,245,076
Ensembl chr 1:158,120,200...158,252,012

G

heparin-binding EGF-like growth factor

increases expression

Bleomycin results in increased expression of HBEGF mRNA

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

hematopoietic cell specific Lyn substrate 1

multiple interactions
increases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of HCLS1 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of HCLS1 mRNA]

NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014

G

hepatocyte growth factor

decreases expression
multiple interactions
increases expression
increases secretion

Bleomycin results in decreased expression of HGF mRNA; Bleomycin results in decreased expression of HGF protein
Berberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]; Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of HGF protein]; lenabasum promotes the reaction [Bleomycin results in decreased expression of HGF protein]
Bleomycin results in increased expression of HGF mRNA
Bleomycin results in increased secretion of HGF protein
Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]; Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF protein]

PMID:16115399 PMID:22687607 PMID:29408570 PMID:30825431

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

[HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of HIF1A mRNA]; HIF1A protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

histone cluster 1, H2bg

decreases expression

Bleomycin results in decreased expression of HIST1H2BG protein

NCBI chr17:41,571,234...41,572,202
Ensembl chr17:41,571,210...41,571,896

G

5-hydroxymethylcytosine binding, ES cell specific

decreases expression

Bleomycin results in decreased expression of HMCES mRNA

NCBI chr 4:120,392,812...120,415,616
Ensembl chr 4:120,366,542...120,415,616

G

high mobility group box 1

multiple interactions
increases expression

protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein]
Bleomycin inhibits the reaction [Azacitidine results in decreased expression of and results in increased secretion of HMGB1 protein]; Bleomycin inhibits the reaction [Azacitidine results in decreased expression of HMGB1 mRNA]

PMID:25582705 PMID:32278510

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

increases expression
multiple interactions
decreases expression

Bleomycin results in increased expression of HMOX1 protein
celastrol inhibits the reaction [Bleomycin results in decreased expression of HMOX1 protein]; Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of HMOX1 mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of HMOX1 mRNA]
PPARA protein affects the reaction [Bleomycin results in increased expression of HMOX1 protein]

PMID:16317386 PMID:26093215 PMID:26768587

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein A2/B1

increases expression

Bleomycin results in increased expression of HNRNPA2B1 protein

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

heterogeneous nuclear ribonucleoprotein A3

increases expression

Bleomycin results in increased expression of HNRNPA3 protein

NCBI chr 3:60,578,574...60,588,755
Ensembl chr 3:60,578,673...60,588,306

G

hemopexin

increases expression

Bleomycin results in increased expression of HPX protein

NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328

G

heat shock protein 90 alpha family class A member 1

multiple interactions

[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90AA1 protein

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 beta family member 1

multiple interactions

[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90B1 protein

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 1A

increases expression
multiple interactions

Bleomycin results in increased expression of HSPA1A mRNA
geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1A mRNA]

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

increases expression
multiple interactions

Bleomycin results in increased expression of HSPA1B mRNA
geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1B mRNA]

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

Bleomycin results in increased expression of HSPA5 protein
pachymic acid inhibits the reaction [Bleomycin results in increased expression of HSPA5 protein]

PMID:25933445 PMID:37163307

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

decreases expression

Bleomycin results in decreased expression of HSPB1 protein

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family E (Hsp10) member 1

increases expression

Bleomycin results in increased expression of HSPE1 protein

PMID:25933445 PMID:29733421

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

5-hydroxytryptamine receptor 1F

decreases expression

Bleomycin results in decreased expression of HTR1F mRNA

NCBI chr11:2,642,751...2,644,150
Ensembl chr11:2,642,751...2,644,150

G

5-hydroxytryptamine receptor 5A

decreases expression

Bleomycin results in decreased expression of HTR5A mRNA

NCBI chr 4:7,444,968...7,454,651
Ensembl chr 4:7,444,968...7,454,651

G

5-hydroxytryptamine (serotonin) receptor 5B

decreases expression

Bleomycin results in decreased expression of HTR5B mRNA

NCBI chr13:32,686,911...32,699,835
Ensembl chr13:32,687,042...32,699,835

G

intercellular adhesion molecule 1

increases expression

Bleomycin results in increased expression of ICAM1 mRNA

PMID:29033951 PMID:29720568

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

isocitrate dehydrogenase (NADP(+)) 2

decreases expression

Bleomycin results in decreased expression of IDH2 protein

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

interferon induced transmembrane protein 1

increases expression
multiple interactions

Bleomycin results in increased expression of IFITM1 mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of IFITM1 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of IFITM1 mRNA]

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

G

interferon gamma

increases expression
multiple interactions
decreases expression

Bleomycin results in increased expression of IFNG mRNA
[Bleomycin co-treated with Tobacco Smoke Pollution] results in increased expression of IFNG protein
Bleomycin results in decreased expression of IFNG protein
[SPL-334 co-treated with Bleomycin] results in increased expression of IFNG protein
Bleomycin results in decreased expression of IFNG mRNA

PMID:11350791 PMID:25071917 PMID:26209236 PMID:29408570 PMID:33516805 More...

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

increases expression

Bleomycin results in increased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

IKBKB interacting protein

increases expression

Bleomycin results in increased expression of IKBIP mRNA

NCBI chr 7:25,579,865...25,598,548
Ensembl chr 7:25,579,832...25,605,162

G

interleukin 10

increases expression
increases secretion
multiple interactions

Bleomycin results in increased expression of IL10 protein
Bleomycin results in increased secretion of IL10 protein
yupingfeng inhibits the reaction [Bleomycin results in increased secretion of IL10 protein]

PMID:29175452 PMID:37898439

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 10 receptor subunit alpha

increases expression

Bleomycin results in increased expression of IL10RA mRNA

NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061

G

interleukin 12B

increases expression

Bleomycin results in increased expression of IL12B mRNA; Bleomycin results in increased expression of IL12B protein

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 12 receptor subunit beta 2

increases expression

Bleomycin results in increased expression of IL12RB2 mRNA

NCBI chr 4:96,426,396...96,515,251
Ensembl chr 4:96,426,842...96,515,289

G

interleukin 13

decreases response to substance
multiple interactions

IL13 gene mutant form results in decreased susceptibility to Bleomycin
IL13 protein affects the reaction [Bleomycin results in increased expression of RETNLA mRNA]

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 13 receptor subunit alpha 1

multiple interactions
increases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of IL13RA1 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of IL13RA1 mRNA]

PMID:30825431 PMID:36087614

NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681

G

interleukin 17A

multiple interactions
increases expression

Curcumin inhibits the reaction [Bleomycin results in increased expression of IL17A mRNA]

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 17 receptor D

increases expression

Bleomycin results in increased expression of IL17RD mRNA

NCBI chr16:2,228,438...2,295,122
Ensembl chr16:2,228,287...2,292,556

G

interleukin 17 receptor E

increases expression

Bleomycin results in increased expression of IL17RE mRNA

NCBI chr 4:146,604,547...146,618,206
Ensembl chr 4:146,605,526...146,618,206

G

interleukin 1 alpha

multiple interactions
increases expression

5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Bleomycin results in increased expression of IL1A mRNA]; Apigenin inhibits the reaction [Bleomycin results in increased expression of IL1A mRNA]; IL1A protein promotes the reaction [Bleomycin results in increased expression of CAT protein]; IL1A protein promotes the reaction [Bleomycin results in increased expression of SOD1 protein]; IL1A protein promotes the reaction [Bleomycin results in increased expression of SOD2 protein]
Bleomycin results in increased expression of IL1A protein

PMID:8317554 PMID:29175452 PMID:32554301

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression
increases secretion
affects expression

12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; [Bleomycin co-treated with Cannabidiol analog] results in decreased expression of IL1B mRNA; [Bleomycin co-treated with Rosiglitazone] results in decreased expression of IL1B mRNA; Calcitriol inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of IL1B mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; Grape Seed Extract inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; honokiol inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; pirinixic acid inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; PPARA protein affects the reaction [Bleomycin results in increased expression of IL1B protein]; Rosiglitazone inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; SLCO2A1 gene mutant form promotes the reaction [Bleomycin results in increased expression of IL1B mRNA]; TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of IL1B protein]; verlukast inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; zileuton inhibits the reaction [Bleomycin results in increased expression of IL1B protein]
Bleomycin affects the expression of IL1B mRNA
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; Apigenin inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; IL1B protein promotes the reaction [Bleomycin results in increased expression of CAT protein]; IL1B protein promotes the reaction [Bleomycin results in increased expression of SOD1 protein]; IL1B protein promotes the reaction [Bleomycin results in increased expression of SOD2 protein]; yupingfeng inhibits the reaction [Bleomycin results in increased secretion of IL1B protein]
Bleomycin results in increased expression of IL1B mRNA; Bleomycin results in increased expression of IL1B protein
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Bleomycin results in increased expression of IL1B protein]

PMID:8317554 PMID:8473757 PMID:16317386 PMID:17035056 PMID:17118201 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

increases expression

Bleomycin results in increased expression of IL1RL1 mRNA; Bleomycin results in increased expression of IL1RL1 protein

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 2

multiple interactions

[Bleomycin co-treated with Tobacco Smoke Pollution] results in increased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 33

increases expression

Bleomycin results in increased expression of IL33 mRNA; Bleomycin results in increased expression of IL33 protein

PMID:36087614 PMID:37399107

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

G

interleukin 4

increases expression
multiple interactions
increases secretion
affects response to substance
decreases response to substance

Bleomycin results in increased expression of IL4 mRNA
yupingfeng inhibits the reaction [Bleomycin results in increased secretion of IL4 protein]
IL4 protein affects the susceptibility to Bleomycin
Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of IL4 mRNA]; IL4 protein affects the reaction [Bleomycin results in increased expression of RETNLA mRNA]; Rosiglitazone inhibits the reaction [Bleomycin results in increased expression of IL4 mRNA]
IL4 gene mutant form results in decreased susceptibility to Bleomycin

PMID:11554783 PMID:12574379 PMID:15322207 PMID:30033591 PMID:37898439

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

increases expression
multiple interactions
increases secretion

Bleomycin results in increased expression of IL6 mRNA; Bleomycin results in increased expression of IL6 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Apigenin inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Ephedrine inhibits the reaction [Bleomycin results in increased secretion of IL6 protein]
Calcitriol inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 protein]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Grape Seed Extract inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; honokiol inhibits the reaction [Bleomycin results in increased expression of IL6 protein]; Oils, Volatile inhibits the reaction [Bleomycin results in increased expression of IL6 protein]; Rosiglitazone inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; SPL-334 inhibits the reaction [Bleomycin results in increased expression of IL6 protein]
allyl sulfide inhibits the reaction [Bleomycin results in increased expression of IL6 protein]; Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; resveratrol inhibits the reaction [Bleomycin results in increased expression of IL6 protein]

PMID:17035056 PMID:18684396 PMID:23656969 PMID:25071917 PMID:26093215 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 7

increases expression

Bleomycin results in increased expression of IL7 protein

NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075

G

insulin induced gene 1

multiple interactions
decreases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of INSIG1 mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of INSIG1 mRNA]

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

integrin subunit beta 2

increases expression
multiple interactions

Bleomycin results in increased expression of ITGB2 mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of ITGB2 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of ITGB2 mRNA]

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

Jupiter microtubule associated homolog 1

increases expression

Bleomycin results in increased expression of JPT1 protein

NCBI chr10:100,744,468...100,762,504
Ensembl chr10:100,686,797...100,784,513

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases activity
multiple interactions
increases phosphorylation

Bleomycin results in increased activity of JUN protein
Bleomycin results in increased expression of [JUN protein binds to FOS protein]; Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of JUN protein]

PMID:12003776 PMID:35716765 PMID:37399107

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

Kelch-like ECH-associated protein 1

decreases expression
increases expression
multiple interactions

Bleomycin results in decreased expression of KEAP1 protein
Bleomycin results in increased expression of KEAP1 protein
Ephedrine inhibits the reaction [Bleomycin results in increased expression of KEAP1 protein]
celastrol inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein]

PMID:26768587 PMID:37778983

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

KH-type splicing regulatory protein

increases expression

Bleomycin results in increased expression of KHSRP protein

NCBI chr 9:1,862,555...1,872,403
Ensembl chr 9:1,862,899...1,872,451

G

KIT proto-oncogene receptor tyrosine kinase

increases expression
multiple interactions

Bleomycin results in increased expression of KIT protein
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in increased expression of KIT protein

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

Klotho

decreases expression

Bleomycin results in decreased expression of KL mRNA

NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080

G

kelch-like family, member 42

increases expression

Bleomycin results in increased expression of KLHL42 mRNA

NCBI chr 4:179,999,655...180,027,283
Ensembl chr 4:180,004,580...180,027,283

G

KRAS proto-oncogene, GTPase

multiple interactions

[Bleomycin co-treated with 1-nitropyrene] results in increased mutagenesis of KRAS gene

NCBI chr 4:178,185,418...178,218,484

G

keratin 13

increases expression

Bleomycin results in increased expression of KRT13 mRNA

NCBI chr10:85,051,887...85,056,099
Ensembl chr10:85,051,889...85,056,084

G

keratin 19

decreases expression

Bleomycin results in decreased expression of KRT19 protein

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

keratin 8

multiple interactions
decreases expression

Ephedrine inhibits the reaction [Bleomycin results in decreased expression of KRT8 mRNA]; Ephedrine inhibits the reaction [Bleomycin results in decreased expression of KRT8 protein]
Bleomycin results in decreased expression of KRT8 mRNA; Bleomycin results in decreased expression of KRT8 protein

NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728

G

keratin 87

increases expression

Bleomycin results in increased expression of KRT87 mRNA

NCBI chr 7:132,547,388...132,555,005
Ensembl chr 7:132,548,141...132,554,978

G

leucine aminopeptidase 3

increases expression

Bleomycin results in increased expression of LAP3 protein

NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359

G

LIM and SH3 protein 1

increases expression

Bleomycin results in increased expression of LASP1 protein

NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292

G

lipocalin 2

increases expression

Bleomycin results in increased expression of LCN2 mRNA; Bleomycin results in increased expression of LCN2 protein

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

lymphocyte cytosolic protein 1

increases expression
multiple interactions

Bleomycin results in increased expression of LCP1 mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of LCP1 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of LCP1 mRNA]

NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680

G

lactate dehydrogenase A like 1

decreases expression

Bleomycin results in decreased expression of LDHAL1 protein

NCBI chr 8:30,363,220...30,364,836

G

leptin

increases expression

Bleomycin results in increased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 3

increases expression
multiple interactions

Bleomycin results in increased expression of LGALS3 protein
NOS2 protein affects the reaction [Bleomycin results in increased expression of LGALS3 protein]

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

galectin 9

increases expression
multiple interactions

Bleomycin results in increased expression of LGALS9 mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of LGALS9 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of LGALS9 mRNA]

NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045

G

luteinizing hormone subunit beta

multiple interactions
increases expression

thymoquinone inhibits the reaction [Bleomycin results in increased expression of LHB protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

LHFPL tetraspan subfamily member 6

multiple interactions
decreases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of LHFPL6 mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of LHFPL6 mRNA]

NCBI chr 2:137,126,485...137,324,442
Ensembl chr 2:137,126,509...137,324,443

G

LIM homeobox 1

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of LHX1 mRNA

NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617

G

lipase H

decreases expression

Bleomycin results in decreased expression of LIPH mRNA

NCBI chr11:79,032,229...79,081,625
Ensembl chr11:79,033,312...79,081,625

G

lamin A/C

increases expression

Bleomycin results in increased expression of LMNA protein

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

leupaxin

multiple interactions
increases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of LPXN mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of LPXN mRNA]

NCBI chr 1:209,928,297...209,963,085
Ensembl chr 1:209,929,202...209,963,084

G

lysozyme 2

decreases expression

Bleomycin results in decreased expression of LYZ protein

NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106

G

macroH2A.1 histone

decreases expression

Bleomycin results in decreased expression of MACROH2A1 protein

NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072

G

microtubule-associated protein 1 light chain 3 beta

increases expression
multiple interactions

Bleomycin results in increased expression of MAP1LC3B protein modified form
Soot inhibits the reaction [Bleomycin results in increased expression of MAP1LC3B protein modified form]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase 1

multiple interactions

Bleomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Bleomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Bleomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Bleomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

myristoylated alanine rich protein kinase C substrate

decreases expression

Bleomycin results in decreased expression of MARCKS protein

NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012

G

malate dehydrogenase 2

decreases expression
multiple interactions

Bleomycin results in decreased expression of MDH2 protein
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of MDH2 protein

PMID:25933445 PMID:29733421

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

methyl CpG binding protein 2

affects response to substance

MECP2 protein affects the susceptibility to Bleomycin

NCBI chr X:151,781,177...151,844,687
Ensembl chr X:151,789,930...151,844,689

G

methylphosphate capping enzyme

increases expression

Bleomycin results in increased expression of MEPCE mRNA

NCBI chr12:18,911,796...18,916,515
Ensembl chr12:18,911,796...18,916,514

G

MER proto-oncogene, tyrosine kinase

multiple interactions
increases phosphorylation

Bleomycin affects the localization of and affects the expression of MERTK protein
Bleomycin results in increased phosphorylation of MERTK protein

NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554

G

mitofusin 1

decreases expression

Bleomycin results in decreased expression of MFN1 protein

NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640

G

mitofusin 2

decreases expression

Bleomycin results in decreased expression of MFN2 protein

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

macrophage migration inhibitory factor

decreases expression

Bleomycin results in decreased expression of MIF protein

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

microRNA 100

decreases expression

Bleomycin results in decreased expression of MIR100 mRNA

NCBI chr 8:41,901,225...41,901,304
Ensembl chr 8:41,901,225...41,901,304

G

microRNA 101-2

decreases expression

Bleomycin results in decreased expression of MIR101B mRNA

PMID:25933445 PMID:28726637

NCBI chr 1:226,860,371...226,860,467
Ensembl chr 1:226,860,371...226,860,467

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microRNA 101a

multiple interactions
decreases expression

MIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; MIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of COL3A1 mRNA]; MIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of FZD6 mRNA]; MIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of NFATC2 mRNA]; MIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]
Bleomycin results in decreased expression of MIR101A mRNA

PMID:25933445 PMID:28726637

NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410

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microRNA 106b

affects expression

Bleomycin affects the expression of MIR106B mRNA

NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425

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microRNA 107

decreases expression

Bleomycin results in decreased expression of MIR107 mRNA

NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853

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microRNA 10a

decreases expression

Bleomycin results in decreased expression of MIR10A mRNA

NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280

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microRNA 10b

decreases expression

Bleomycin results in decreased expression of MIR10B mRNA

NCBI chr 3:59,628,438...59,628,546
Ensembl chr 3:59,628,438...59,628,546

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microRNA 1224

increases expression

Bleomycin results in increased expression of MIR1224 mRNA

NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986

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microRNA 1249

affects expression

Bleomycin affects the expression of MIR1249 mRNA

NCBI chr 7:116,075,593...116,075,712
Ensembl chr 7:116,075,593...116,075,712

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microRNA 125a

affects expression

Bleomycin affects the expression of MIR125A mRNA

NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710

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microRNA 126a

decreases expression

Bleomycin results in decreased expression of MIR126 mRNA

NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180

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microRNA 130a

decreases expression

Bleomycin results in decreased expression of MIR130A mRNA

NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629

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microRNA 133a-1

decreases expression

Bleomycin results in decreased expression of MIR133A1 mRNA

NCBI chr18:1,885,082...1,885,168

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microRNA 133b

decreases expression

Bleomycin results in decreased expression of MIR133B mRNA

NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217

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microRNA 140

affects expression

Bleomycin affects the expression of MIR140 mRNA

NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675

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microRNA 141

affects expression

Bleomycin affects the expression of MIR141 mRNA

NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332

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microRNA 142

decreases expression
increases expression

Bleomycin results in decreased expression of MIR142 mRNA
Bleomycin results in increased expression of MIR142 mRNA

NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967

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microRNA 143

decreases expression

Bleomycin results in decreased expression of MIR143 mRNA

NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110

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microRNA 144

decreases expression

Bleomycin results in decreased expression of MIR144 mRNA

NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430

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microRNA 145

decreases expression

Bleomycin results in decreased expression of MIR145 mRNA

NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727

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microRNA 146a

affects expression

Bleomycin affects the expression of MIR146A mRNA

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

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microRNA 146b

increases expression

Bleomycin results in increased expression of MIR146B mRNA

NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525

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microRNA 148b

decreases expression

Bleomycin results in decreased expression of MIR148B mRNA

NCBI chr 7:134,421,398...134,421,494
Ensembl chr 7:134,421,398...134,421,494

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microRNA 150

affects expression

Bleomycin affects the expression of MIR150 mRNA

NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108

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microRNA 151

decreases expression

Bleomycin results in decreased expression of MIR151 mRNA

NCBI chr 7:105,172,377...105,172,473

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microRNA 152

decreases expression

Bleomycin results in decreased expression of MIR152 mRNA

NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020

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microRNA 15b

affects expression

Bleomycin affects the expression of MIR15B mRNA

NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297

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microRNA 16

decreases expression

Bleomycin results in decreased expression of MIR16 mRNA

NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443

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microRNA 17

affects expression

Bleomycin affects the expression of MIR17 mRNA

NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712

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microRNA 181c

decreases expression

Bleomycin results in decreased expression of MIR181C mRNA

NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628

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microRNA 181d

decreases expression

Bleomycin results in decreased expression of MIR181D mRNA

NCBI chr19:23,983,706...23,983,788
Ensembl chr19:23,983,706...23,983,788

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microRNA 183

affects expression

Bleomycin affects the expression of MIR183 mRNA

NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723

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microRNA 185

decreases expression

Bleomycin results in decreased expression of MIR185 mRNA

NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795

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microRNA 186

decreases expression

Bleomycin results in decreased expression of MIR186 mRNA

NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891

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microRNA 188

affects expression

Bleomycin affects the expression of MIR188 mRNA

NCBI chr X:15,247,715...15,247,794
Ensembl chr X:15,247,715...15,247,794

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microRNA 18a

increases expression

Bleomycin results in increased expression of MIR18A mRNA

NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860

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microRNA 193

decreases expression

Bleomycin results in decreased expression of MIR193 mRNA

NCBI chr10:64,672,354...64,672,439

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microRNA 195

decreases expression

Bleomycin results in decreased expression of MIR195 mRNA

NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924

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microRNA 199a-2

affects expression

Bleomycin affects the expression of MIR199A2 mRNA

NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063

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microRNA 19a

affects expression

Bleomycin affects the expression of MIR19A mRNA

NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993

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microRNA 200a

decreases expression

Bleomycin results in decreased expression of MIR200A mRNA

NCBI chr 5:166,648,494...166,648,582

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microRNA 200b

decreases expression

Bleomycin results in decreased expression of MIR200B mRNA

NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366

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microRNA 200c

decreases expression

Bleomycin results in decreased expression of MIR200C mRNA

NCBI chr 4:157,523,679...157,523,747

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microRNA 204

decreases expression

Bleomycin results in decreased expression of MIR204 mRNA

NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040

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microRNA 20a

affects expression

Bleomycin affects the expression of MIR20A mRNA

NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168

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microRNA 20b

affects expression

Bleomycin affects the expression of MIR20B mRNA

NCBI chr X:132,422,211...132,422,282
Ensembl chr X:132,422,211...132,422,282

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microRNA 21

increases expression

Bleomycin results in increased expression of MIR21 mRNA

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

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microRNA 210

decreases expression

Bleomycin results in decreased expression of MIR210 mRNA

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

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microRNA 211

affects expression

Bleomycin affects the expression of MIR211 mRNA

NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644

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microRNA 212

affects expression

Bleomycin affects the expression of MIR212 mRNA

NCBI chr10:60,023,403...60,023,513
Ensembl chr10:60,023,403...60,023,513

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microRNA 214

affects expression

Bleomycin affects the expression of MIR214 mRNA

NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481

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microRNA 22

affects expression

Bleomycin affects the expression of MIR22 mRNA

NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133

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microRNA 221

decreases expression

Bleomycin results in decreased expression of MIR221 mRNA

NCBI chr X:3,429,465...3,429,573
Ensembl chr X:3,429,465...3,429,573

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microRNA 222

decreases expression
affects expression

Bleomycin results in decreased expression of MIR222 mRNA
Bleomycin affects the expression of MIR222 mRNA

PMID:25933445 PMID:34425168

NCBI chr X:3,428,904...3,429,006
Ensembl chr X:3,428,904...3,429,006

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microRNA 223

affects expression

Bleomycin affects the expression of MIR223 mRNA

NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996

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microRNA 23a

decreases expression

Bleomycin results in decreased expression of MIR23A mRNA

NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071

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microRNA 23b

decreases expression

Bleomycin results in decreased expression of MIR23B mRNA

NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763

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microRNA 24-2

decreases expression

Bleomycin results in decreased expression of MIR24-2 mRNA

NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790

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microRNA 25

affects expression

Bleomycin affects the expression of MIR25 mRNA

NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015

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microRNA 26a

decreases expression

Bleomycin results in decreased expression of MIR26A mRNA
Bleomycin results in decreased expression of MIR26A-1

PMID:25933445 PMID:35785413

NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378

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microRNA 26b

decreases expression

Bleomycin results in decreased expression of MIR26B mRNA

NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680

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microRNA 27a

decreases expression

Bleomycin results in decreased expression of MIR27A mRNA

NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917

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microRNA 27b

decreases expression

Bleomycin results in decreased expression of MIR27B mRNA

NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529

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microRNA 28

decreases expression

Bleomycin results in decreased expression of MIR28 mRNA

NCBI chr11:75,975,523...75,975,608
Ensembl chr11:75,975,523...75,975,608

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microRNA 290

increases expression

Bleomycin results in increased expression of MIR290 mRNA

NCBI chr 1:65,964,648...65,964,728
Ensembl chr 1:65,964,648...65,964,728

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microRNA 296

affects expression

Bleomycin affects the expression of MIR296 mRNA

NCBI chr 3:163,051,838...163,051,915
Ensembl chr 3:163,051,838...163,051,915

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microRNA 2985

affects expression

Bleomycin affects the expression of MIR2985 mRNA

NCBI chr 2:165,956,389...165,956,498
Ensembl chr 2:165,956,389...165,956,498

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microRNA 29a

decreases expression

Bleomycin results in decreased expression of MIR29A mRNA

NCBI chr 4:59,650,608...59,650,695

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microRNA 301a

affects expression

Bleomycin affects the expression of MIR301A mRNA

NCBI chr10:71,925,336...71,925,435
Ensembl chr10:71,925,336...71,925,435

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microRNA 30a

decreases expression

Bleomycin results in decreased expression of MIR30A mRNA

NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670

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microRNA 30b

decreases expression

Bleomycin results in decreased expression of MIR30B mRNA

NCBI chr 7:100,132,589...100,132,675
Ensembl chr 7:100,132,589...100,132,675

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microRNA 30c-2

decreases expression

Bleomycin results in decreased expression of MIR30C2 mRNA

NCBI chr 9:25,757,342...25,757,425
Ensembl chr 9:25,757,342...25,757,425

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microRNA 30d

decreases expression

Bleomycin results in decreased expression of MIR30D mRNA

NCBI chr 7:100,136,391...100,136,472
Ensembl chr 7:100,136,391...100,136,472

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microRNA 30e

decreases expression

Bleomycin results in decreased expression of MIR30E mRNA

NCBI chr 5:134,352,232...134,352,323
Ensembl chr 5:134,352,232...134,352,323

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microRNA 31

decreases expression

Bleomycin results in decreased expression of MIR31 mRNA

NCBI chr 5:103,599,038...103,599,143

G

microRNA 32

increases expression

Bleomycin results in increased expression of MIR32 mRNA

NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152

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microRNA 320a

decreases expression

Bleomycin results in decreased expression of MIR320A mRNA

NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473

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microRNA 322

decreases expression

Bleomycin results in decreased expression of MIR322 mRNA

NCBI chr X:132,806,594...132,806,688
Ensembl chr X:132,806,594...132,806,688

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microRNA 324

affects expression

Bleomycin affects the expression of MIR324 mRNA

NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766

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microRNA 326

decreases expression

Bleomycin results in decreased expression of MIR326 mRNA

NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123

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microRNA 328

affects expression

Bleomycin affects the expression of MIR328 mRNA

NCBI chr19:33,184,766...33,184,849
Ensembl chr19:33,184,766...33,184,849

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microRNA 33

decreases expression

Bleomycin results in decreased expression of MIR33 mRNA

NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923

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microRNA 330

decreases expression

Bleomycin results in decreased expression of MIR330 mRNA

NCBI chr 1:78,833,178...78,833,274
Ensembl chr 1:78,833,178...78,833,274

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microRNA 331

decreases expression

Bleomycin results in decreased expression of MIR331 mRNA

NCBI chr 7:28,527,390...28,527,485
Ensembl chr 7:28,527,390...28,527,485

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microRNA 340-1

increases expression

Bleomycin results in increased expression of MIR340-1 mRNA

NCBI chr10:34,393,568...34,393,665
Ensembl chr10:34,393,568...34,393,665

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microRNA 342

decreases expression

Bleomycin results in decreased expression of MIR342 mRNA

NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367

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microRNA 345

decreases expression

Bleomycin results in decreased expression of MIR345 mRNA

NCBI chr 6:127,754,027...127,754,122
Ensembl chr 6:127,754,027...127,754,122

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microRNA mir-347

decreases expression

Bleomycin results in decreased expression of MIR347 mRNA

G

microRNA 3473

increases expression

Bleomycin results in increased expression of MIR3473 mRNA

NCBI chr13:39,499,246...39,499,312
Ensembl chr13:39,499,246...39,499,312

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microRNA 34a

affects expression
decreases expression

Bleomycin affects the expression of MIR34A mRNA
Bleomycin results in decreased expression of MIR34A mRNA

PMID:25933445 PMID:34425168

NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103

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microRNA 34b

decreases expression

Bleomycin results in decreased expression of MIR34B mRNA

NCBI chr 8:51,410,244...51,410,327
Ensembl chr 8:51,410,244...51,410,327

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microRNA 34c

decreases expression

Bleomycin results in decreased expression of MIR34C mRNA

NCBI chr 8:51,409,726...51,409,802
Ensembl chr 8:51,409,726...51,409,802

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microRNA mir-352

decreases expression

Bleomycin results in decreased expression of MIR352 mRNA

G

microRNA 3545

decreases expression

Bleomycin results in decreased expression of MIR203 mRNA

NCBI chr 6:131,199,542...131,199,656
Ensembl chr 6:131,199,542...131,199,656

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microRNA 3573

decreases expression

Bleomycin results in decreased expression of MIR3573 mRNA

NCBI chr X:64,259,096...64,259,167
Ensembl chr X:64,259,096...64,259,167

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microRNA 3584

affects expression

Bleomycin affects the expression of MIR3584 mRNA

NCBI chr 1:246,786,249...246,786,329
Ensembl chr 1:246,786,249...246,786,329

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microRNA 361

decreases expression

Bleomycin results in decreased expression of MIR361 mRNA

NCBI chr X:78,246,206...78,246,275
Ensembl chr X:78,246,206...78,246,275

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microRNA 365b

decreases expression

Bleomycin results in decreased expression of MIR365B mRNA

NCBI chr10:64,686,255...64,686,340
Ensembl chr10:64,686,252...64,686,351

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microRNA 374b

decreases expression

Bleomycin results in decreased expression of MIR374B mRNA

NCBI chr X:68,591,732...68,591,799
Ensembl chr X:68,591,732...68,591,799

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microRNA 375

decreases expression

Bleomycin results in decreased expression of MIR375 mRNA

NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985

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microRNA 378

decreases expression

Bleomycin results in decreased expression of MIR378 mRNA

NCBI chr18:54,858,559...54,858,623

G

microRNA 409

affects expression

Bleomycin affects the expression of MIR409 mRNA

NCBI chr 6:128,757,780...128,757,856
Ensembl chr 6:128,757,779...128,757,858

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microRNA 423

decreases expression

Bleomycin results in decreased expression of MIR423 mRNA

NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226

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microRNA 425

affects expression

Bleomycin affects the expression of MIR425 mRNA

NCBI chr 8:109,264,555...109,264,637
Ensembl chr 8:109,264,555...109,264,637

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microRNA 429

decreases expression

Bleomycin results in decreased expression of MIR429 mRNA

NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543

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microRNA 449a

affects expression

Bleomycin affects the expression of MIR449A mRNA

NCBI chr 2:44,670,714...44,670,804
Ensembl chr 2:44,670,714...44,670,804

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microRNA 450a-1

decreases expression

Bleomycin results in decreased expression of MIR450A1 mRNA

NCBI chr X:132,801,380...132,801,470
Ensembl chr X:132,801,380...132,801,470

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microRNA 451a

decreases expression

Bleomycin results in decreased expression of MIR451A mRNA
Bleomycin results in decreased expression of MIR451A protein

PMID:25933445 PMID:34460027

NCBI chr10:62,961,520...62,961,591
Ensembl chr10:62,961,520...62,961,591

G

microRNA 494

decreases expression

Bleomycin results in decreased expression of MIR494 mRNA

NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793

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microRNA 497

decreases expression

Bleomycin results in decreased expression of MIR497 mRNA

NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584

G

microRNA 500

affects expression

Bleomycin affects the expression of MIR500 mRNA

NCBI chr X:15,258,778...15,258,857
Ensembl chr X:15,258,768...15,258,859

G

microRNA 503

decreases expression

Bleomycin results in decreased expression of MIR503 mRNA

NCBI chr X:132,806,303...132,806,373
Ensembl chr X:132,806,303...132,806,373

G

microRNA 532

affects expression

Bleomycin affects the expression of MIR532 mRNA

NCBI chr X:15,247,315...15,247,393
Ensembl chr X:15,247,315...15,247,393

G

microRNA 542

decreases expression

Bleomycin results in decreased expression of MIR542 mRNA

NCBI chr X:132,802,623...132,802,701
Ensembl chr X:132,802,623...132,802,701

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microRNA 6215

decreases expression

Bleomycin results in decreased expression of MIR6215 mRNA

NCBI chr 5:151,850,759...151,850,825
Ensembl chr 5:151,850,759...151,850,825

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microRNA 6216

decreases expression

Bleomycin results in decreased expression of MIR6216 mRNA

NCBI chr 3:44,756,861...44,756,938
Ensembl chr 3:44,756,861...44,756,938

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microRNA 6328

affects expression

Bleomycin affects the expression of MIR6328 mRNA

NCBI chr20:2,885,300...2,885,396
Ensembl chr20:2,885,300...2,885,396

G

microRNA 652

affects expression

Bleomycin affects the expression of MIR652 mRNA

NCBI chr X:106,343,293...106,343,373
Ensembl chr X:106,343,293...106,343,373

G

microRNA 93

affects expression

Bleomycin affects the expression of MIR93 mRNA

NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221

G

microRNA 96

affects expression

Bleomycin affects the expression of MIR96 mRNA

NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516

G

microRNA 98

decreases expression

Bleomycin results in decreased expression of MIR98 mRNA

NCBI chr X:20,981,235...20,981,342
Ensembl chr X:20,981,235...20,981,342

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microRNA 99a

decreases expression

Bleomycin results in decreased expression of MIR99A mRNA

NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523

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microRNA 99b

decreases expression

Bleomycin results in decreased expression of MIR99B mRNA

NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090

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microRNA let-7b

decreases expression

Bleomycin results in decreased expression of MIRLET7B mRNA

NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270

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microRNA let-7d

decreases expression

Bleomycin results in decreased expression of MIRLET7D mRNA

NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990

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microRNA let-7i

decreases expression

Bleomycin results in decreased expression of MIRLET7I mRNA

NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571

G

matrix metallopeptidase 1

increases expression

Bleomycin results in increased expression of MMP1 mRNA; Bleomycin results in increased expression of MMP1 protein

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 2

multiple interactions
increases expression

allyl sulfide inhibits the reaction [Bleomycin results in increased expression of MMP2 protein]; celastrol inhibits the reaction [Bleomycin results in increased expression of MMP2 protein]
Bleomycin results in increased expression of and results in increased secretion of MMP2 protein; Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP2 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP2 mRNA]
Bleomycin results in increased expression of MMP2 mRNA; Bleomycin results in increased expression of MMP2 protein

PMID:23656969 PMID:26345256 PMID:26768587 PMID:29175452 PMID:35716765

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

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matrix metallopeptidase 23

increases expression

Bleomycin results in increased expression of MMP23 mRNA

NCBI chr 5:166,239,643...166,242,734
Ensembl chr 5:166,239,644...166,242,433

G

matrix metallopeptidase 3

multiple interactions
increases expression

[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of MMP3 mRNA]; MMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Bleomycin results in increased expression of MMP3 mRNA]; Apigenin inhibits the reaction [Bleomycin results in increased expression of MMP3 mRNA]

PMID:28434932 PMID:32554301

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 7

increases expression
multiple interactions

Bleomycin results in increased expression of MMP7 protein
honokiol inhibits the reaction [Bleomycin results in increased expression of MMP7 protein]

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

increases expression
multiple interactions

Bleomycin results in increased expression of MMP9 protein
12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of MMP9 mRNA]; 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of MMP9 protein]; Bleomycin results in increased expression of and results in increased secretion of MMP9 protein; Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP9 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP9 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of MMP9 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of MMP9 protein]; Grape Seed Extract inhibits the reaction [Bleomycin results in increased expression of MMP9 protein]; NOS2 protein affects the reaction [Bleomycin results in increased expression of MMP9 protein]
Bleomycin results in increased expression of MMP9 mRNA; Bleomycin results in increased expression of MMP9 protein
allyl sulfide inhibits the reaction [Bleomycin results in increased expression of MMP9 protein]; celastrol inhibits the reaction [Bleomycin results in increased expression of MMP9 protein]

PMID:23656969 PMID:26526764 PMID:26768587 PMID:28300665 PMID:28694203 More...

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

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myeloperoxidase

multiple interactions
increases expression
increases activity

Oils, Volatile inhibits the reaction [Bleomycin results in increased activity of MPO protein]; pirinixic acid inhibits the reaction [Bleomycin results in increased activity of MPO protein]; verlukast inhibits the reaction [Bleomycin results in increased activity of MPO protein]; zileuton inhibits the reaction [Bleomycin results in increased activity of MPO protein]
Bleomycin results in increased expression of MPO protein
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MPO protein]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of MPO protein]; resveratrol inhibits the reaction [Bleomycin results in increased activity of MPO protein]

PMID:16317386 PMID:17035056 PMID:17118201 PMID:26093215 PMID:28850077

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mannose receptor, C type 1

increases expression

Bleomycin results in increased expression of MRC1 mRNA

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

moesin

decreases expression

Bleomycin results in decreased expression of MSN protein

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

mucin 5AC, oligomeric mucus/gel-forming

increases expression
multiple interactions

Bleomycin results in increased expression of MUC5AC mRNA
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA]

PMID:18684396 PMID:26093215

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

mucin like 3

increases expression

Bleomycin results in increased expression of MUCL3 mRNA

NCBI chr20:3,100,652...3,108,569
Ensembl chr20:3,100,679...3,108,569

G

murinoglobulin 2

increases expression

Bleomycin results in increased expression of PZP protein

NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475

G

MAX interactor 1, dimerization protein

decreases expression

Bleomycin results in decreased expression of MXI1 mRNA

NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681

G

MYC proto-oncogene, bHLH transcription factor

increases response to substance

MYC protein results in increased susceptibility to Bleomycin

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin heavy chain 11

decreases expression

Bleomycin results in decreased expression of MYH11 protein

NCBI chr10:743,364...838,459
Ensembl chr10:743,685...838,459

G

myosin heavy chain 6

decreases expression

Bleomycin results in decreased expression of MYH6 protein

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin light chain 12B

increases expression

Bleomycin results in increased expression of MYL12B protein

NCBI chr 9:110,873,855...110,888,187

G

myosin, light chain 4

decreases expression

Bleomycin results in decreased expression of MYL4 protein

NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363

G

myosin light chain 6

increases expression

Bleomycin results in increased expression of MYL6 protein

NCBI chr 7:910,764...914,062
Ensembl chr 7:910,774...933,791

G

myosin 1C

decreases expression

Bleomycin results in decreased expression of MYO1C protein

NCBI chr10:60,498,372...60,520,752
Ensembl chr10:60,498,280...60,520,752

G

myosin IE

decreases expression

Bleomycin results in decreased expression of MYO1E mRNA

NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169

G

nucleosome assembly protein 1-like 1

decreases expression

Bleomycin results in decreased expression of NAP1L1 protein

NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593

G

nuclear factor of activated T-cells 2

multiple interactions
increases expression

MIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of NFATC2 mRNA]

NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325

G

NFE2 like bZIP transcription factor 2

affects localization
multiple interactions
decreases expression
increases expression
increases phosphorylation

Bleomycin affects the localization of NFE2L2 protein
Ephedrine inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]
Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]; celastrol inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]; Methylprednisolone inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 mRNA]
Bleomycin results in decreased expression of NFE2L2 mRNA; Bleomycin results in decreased expression of NFE2L2 protein
caffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]; U 0126 inhibits the reaction [Bleomycin affects the localization of NFE2L2 protein]; U 0126 inhibits the reaction [Bleomycin results in increased phosphorylation of NFE2L2 protein]

PMID:23523906 PMID:23570914 PMID:26093215 PMID:26768587 PMID:37778983

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

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nuclear factor kappa B subunit 1

increases activity
multiple interactions
increases expression

Bleomycin results in increased activity of NFKB1 protein
NOS2 protein affects the reaction [Bleomycin results in increased activity of NFKB1 protein]
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of NFKB1 mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of NFKB1 mRNA]

PMID:12003776 PMID:26093215 PMID:26526764

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

[Bleomycin results in increased phosphorylation of GSK3B protein] inhibits the reaction [GSK3B protein binds to and results in increased stability of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor zeta

increases expression
multiple interactions

Bleomycin results in increased expression of NFKBIZ mRNA
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Bleomycin results in increased expression of NFKBIZ mRNA]

NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723

G

NHERF family PDZ scaffold protein 1

increases expression

Bleomycin results in increased expression of NHERF1 protein

NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598

G

NHERF family PDZ scaffold protein 2

decreases expression

Bleomycin results in decreased expression of NHERF2 protein

NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049

G

nitrilase family, member 2

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of NIT2 protein

NCBI chr11:43,363,839...43,378,713
Ensembl chr11:43,363,985...43,375,024

G

NLR family, pyrin domain containing 10

increases expression

Bleomycin results in increased expression of NLRP10 mRNA

NCBI chr 1:162,922,806...162,930,363
Ensembl chr 1:162,922,806...162,930,363

G

neuromedin B receptor

decreases expression

Bleomycin results in decreased expression of NMBR mRNA

NCBI chr 1:9,115,033...9,146,081
Ensembl chr 1:9,134,889...9,145,462

G

NME/NM23 nucleoside diphosphate kinase 2

increases expression

Bleomycin results in increased expression of NME2 protein

NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
Ensembl chr20:78,897,770...78,903,538

G

nitric oxide synthase 2

increases expression
multiple interactions
increases secretion

Bleomycin results in increased expression of NOS2 protein
yupingfeng inhibits the reaction [Bleomycin results in increased secretion of NOS2 protein]
Berberine inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; Hydrocortisone inhibits the reaction [Bleomycin results in increased expression of NOS2 mRNA]; Hydrocortisone inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; Taurine inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]
Bleomycin results in increased expression of NOS2 mRNA; Bleomycin results in increased expression of NOS2 protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; NOS2 protein affects the reaction [Bleomycin results in increased activity of NFKB1 protein]; NOS2 protein affects the reaction [Bleomycin results in increased expression of LGALS3 protein]; NOS2 protein affects the reaction [Bleomycin results in increased expression of MMP9 protein]; NOS2 protein affects the reaction [Bleomycin results in increased expression of RETNLA protein]; rosiglitazone inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]

PMID:15684285 PMID:17434272 PMID:19362168 PMID:23523906 PMID:26526764 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 4

increases expression

Bleomycin results in increased expression of NOTCH4 mRNA

NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465

G

NADPH oxidase 4

increases expression
multiple interactions

Bleomycin results in increased expression of NOX4 mRNA
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]; Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]

PMID:35187969 PMID:37307957

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

nucleophosmin 1

increases expression

Bleomycin results in increased expression of NPM1 protein

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
Ensembl chr X:17,739,941...17,751,645

G

NAD(P)H quinone dehydrogenase 1

decreases activity
multiple interactions

Bleomycin results in decreased activity of NQO1 protein
celastrol inhibits the reaction [Bleomycin results in decreased activity of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

Bleomycin results in decreased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 3, group C, member 2

decreases expression

Bleomycin results in decreased expression of NR3C2 mRNA

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

nucleobindin 2

increases expression

Bleomycin results in increased expression of NUCB2 protein

NCBI chr 1:170,750,830...170,787,356
Ensembl chr 1:170,750,877...170,787,353

G

ornithine aminotransferase

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of OAT protein

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

G

8-oxoguanine DNA glycosylase

increases expression
multiple interactions
affects response to substance

Bleomycin results in increased expression of OGG1 protein
OGG1 protein affects the reaction [Bleomycin results in decreased expression of CDH1 protein]; OGG1 protein affects the reaction [Bleomycin results in increased expression of CCN2 protein]; OGG1 protein affects the reaction [Bleomycin results in increased expression of CDH2 protein]; OGG1 protein affects the reaction [Bleomycin results in increased expression of FN1 protein]; OGG1 protein inhibits the reaction [TH5487 inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]]; OGG1 protein inhibits the reaction [TH5487 inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]]; OGG1 protein inhibits the reaction [TH5487 inhibits the reaction [Bleomycin results in increased expression of CDH2 protein]]; OGG1 protein inhibits the reaction [TH5487 inhibits the reaction [Bleomycin results in increased expression of FN1 protein]]; OGG1 protein promotes the reaction [Bleomycin results in increased expression of CCN2 protein]; OGG1 protein promotes the reaction [Bleomycin results in increased expression of FN1 protein]; pirfenidone inhibits the reaction [Bleomycin results in increased expression of OGG1 protein]; TH5487 inhibits the reaction [Bleomycin results in increased expression of OGG1 protein]
OGG1 protein affects the susceptibility to Bleomycin

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

odd-skipped related transcription factor 1

increases expression

Bleomycin results in increased expression of OSR1 protein

NCBI chr 6:32,369,561...32,380,822
Ensembl chr 6:32,373,816...32,380,817

G

osteoclast stimulating factor 1

increases expression

Bleomycin results in increased expression of OSTF1 protein

NCBI chr 1:216,002,037...216,049,226
Ensembl chr 1:216,002,044...216,049,221

G

prolyl 4-hydroxylase subunit beta

increases expression

Bleomycin results in increased expression of P4HB protein

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

poly(A) binding protein, cytoplasmic 1

increases expression

Bleomycin results in increased expression of PABPC1 protein

NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744

G

poly (ADP-ribose) polymerase 1

increases expression
multiple interactions
increases cleavage

Bleomycin results in increased expression of PARP1 protein
Bleomycin inhibits the reaction [Azacitidine results in increased cleavage of PARP1 protein]
Bleomycin results in increased cleavage of PARP1 protein

PMID:15371238 PMID:16317386 PMID:32278510

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

poly(rC) binding protein 2

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of PCBP2 protein

NCBI chr 7:133,605,375...133,631,312
Ensembl chr 7:133,605,573...133,629,863

G

protein disulfide isomerase family A, member 3

multiple interactions

[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of PDIA3 protein

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

G

PDZ and LIM domain 1

increases expression

Bleomycin results in increased expression of PDLIM1 protein

NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076

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PDZ and LIM domain 5

increases expression

Bleomycin results in increased expression of PDLIM5 protein

NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275

G

pyridoxal kinase like 1

increases expression

Bleomycin results in increased expression of PDXK protein

NCBI chr20:10,162,934...10,192,572
Ensembl chr20:10,164,099...10,192,739

G

platelet and endothelial cell adhesion molecule 1

multiple interactions
decreases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of PECAM1 protein]

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

plasminogen activator, urokinase

increases expression
multiple interactions
decreases expression

Bleomycin results in increased expression of PLAU mRNA; Bleomycin results in increased expression of PLAU protein
Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU protein]
Bleomycin results in decreased expression of PLAU mRNA; Bleomycin results in decreased expression of PLAU protein

PMID:25648892 PMID:35716765

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

plasminogen activator, urokinase receptor

decreases expression
multiple interactions

Bleomycin results in decreased expression of PLAUR mRNA; Bleomycin results in decreased expression of PLAUR protein
Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR protein]

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

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PML nuclear body scaffold

multiple interactions
increases expression

arsenic trioxide inhibits the reaction [Bleomycin results in increased expression of PML protein]

NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971

G

purine nucleoside phosphorylase

decreases expression

Bleomycin results in decreased expression of PNP protein

NCBI chr15:24,170,607...24,178,269
Ensembl chr15:24,170,602...24,203,986

G

podocalyxin-like

decreases expression

Bleomycin results in decreased expression of PODXL protein

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

DNA polymerase beta

decreases response to substance

POLB results in decreased susceptibility to Bleomycin

NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812

G

peroxisome proliferator activated receptor alpha

multiple interactions
decreases response to substance

PPARA protein affects the reaction [Bleomycin results in increased expression of HMOX1 protein]; PPARA protein affects the reaction [Bleomycin results in increased expression of IL1B protein]; PPARA protein affects the reaction [Bleomycin results in increased expression of TNF protein]
PPARA protein results in decreased susceptibility to Bleomycin

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

decreases expression
multiple interactions

Bleomycin results in decreased expression of PPARG mRNA; Bleomycin results in decreased expression of PPARG protein
Berberine inhibits the reaction [Bleomycin binds to PPARG protein]
lenabasum inhibits the reaction [Bleomycin results in decreased expression of PPARG protein]; Rosiglitazone inhibits the reaction [Bleomycin results in decreased expression of PPARG mRNA]

PMID:19147827 PMID:27153807 PMID:29408570

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PTPRF interacting protein alpha 4

multiple interactions
increases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of PPFIA4 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of PPFIA4 mRNA]

NCBI chr13:45,753,827...45,802,305
Ensembl chr13:45,753,827...45,802,261

G

peptidylprolyl isomerase A

increases expression

Bleomycin results in increased expression of PPIA protein

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

peroxiredoxin 2

decreases expression

Bleomycin results in decreased expression of PRDX2 protein

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

peroxiredoxin 6

decreases expression

Bleomycin results in decreased expression of PRDX6 protein

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

proline and arginine rich end leucine rich repeat protein

decreases expression

Bleomycin results in decreased expression of PRELP protein

NCBI chr13:45,368,407...45,391,480
Ensembl chr13:45,370,533...45,380,270

G

proteasome 26S subunit, non-ATPase 13

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of PSMD13 protein

NCBI chr 1:195,964,617...195,976,895
Ensembl chr 1:195,964,138...195,976,905

G

proteasome activator subunit 1

increases expression

Bleomycin results in increased expression of PSME1 protein

NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890

G

proteasome activator subunit 2

decreases expression

Bleomycin results in decreased expression of PSME2 protein

NCBI chr15:29,078,495...29,082,794
Ensembl chr15:29,078,500...29,082,946

G

platelet-activating factor receptor

multiple interactions
increases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of PTAFR mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of PTAFR mRNA]

NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251

G

polypyrimidine tract binding protein 1

increases expression

Bleomycin results in increased expression of PTBP1 protein

NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397

G

phosphatase and tensin homolog

multiple interactions
decreases expression

((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN protein]
Bleomycin results in decreased expression of PTEN mRNA; Bleomycin results in decreased expression of PTEN protein

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin D2 receptor

increases expression

Bleomycin results in increased expression of PTGDR mRNA

NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

Bleomycin results in increased expression of PTGS2 mRNA; Bleomycin results in increased expression of PTGS2 protein
2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased expression of PTGS2 protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Bleomycin results in increased expression of PTGS2 mRNA]

PMID:26526764 PMID:27704718 PMID:32828905

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathymosin

increases expression

Bleomycin results in increased expression of PTMS protein

NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009

G

RAB1B, member RAS oncogene family

increases expression

Bleomycin results in increased expression of RAB1B protein

NCBI chr 1:202,405,759...202,413,850
Ensembl chr 1:202,405,759...202,413,868
Ensembl chr X:202,405,759...202,413,868

G

Rac family small GTPase 2

multiple interactions
increases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of RAC2 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of RAC2 mRNA]

NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720

G

RAD51 associated protein 1

decreases expression
multiple interactions

Bleomycin results in decreased expression of RAD51AP1 mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of RAD51AP1 mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of RAD51AP1 mRNA]

NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524

G

RAS like proto-oncogene B

increases expression

Bleomycin results in increased expression of RALB protein

NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202

G

RAP1B, member of RAS oncogene family

increases expression

Bleomycin results in increased expression of RAP1B protein

NCBI chr 7:53,423,039...53,456,349
Ensembl chr 7:53,423,130...53,456,370

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases phosphorylation
decreases expression
increases expression

Calcitriol inhibits the reaction [Bleomycin results in increased expression of RELA protein]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of RELA mRNA]; honokiol inhibits the reaction [Bleomycin results in increased expression of RELA protein modified form]; methyl palmitate inhibits the reaction [Bleomycin results in increased expression of RELA protein]
Ephedrine inhibits the reaction [Bleomycin results in increased phosphorylation of RELA protein]
Bleomycin results in decreased expression of RELA mRNA
Bleomycin results in increased expression of RELA mRNA; Bleomycin results in increased expression of RELA protein; Bleomycin results in increased expression of RELA protein modified form
Berberine inhibits the reaction [Bleomycin affects the localization of and results in increased expression of RELA protein]; Bleomycin affects the localization of and results in increased expression of RELA protein; thymoquinone inhibits the reaction [Bleomycin results in increased expression of RELA protein]

PMID:21575650 PMID:22982510 PMID:23523906 PMID:26520185 PMID:29720568 More...

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RELB proto-oncogene, NF-kB subunit

decreases expression

Bleomycin results in decreased expression of RELB mRNA

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

roundabout guidance receptor 1

decreases expression
multiple interactions

Bleomycin results in decreased expression of ROBO1 mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of ROBO1 mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of ROBO1 mRNA]

NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203

G

ribosomal protein L12

increases expression

Bleomycin results in increased expression of RPL12 protein

NCBI chr 3:16,264,269...16,266,645
Ensembl chr 3:16,264,251...16,266,642

G

ribosomal protein L13

increases expression

Bleomycin results in increased expression of RPL13 protein

NCBI chr19:51,153,990...51,156,541
Ensembl chr19:51,153,924...51,163,014

G

ribosomal protein L4

increases expression

Bleomycin results in increased expression of RPL4 protein

NCBI chr 8:64,671,177...64,676,301
Ensembl chr 8:64,671,160...64,676,306

G

ribosomal protein L5

increases expression

Bleomycin results in increased expression of RPL5 protein

NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290

G

ribosomal protein L6

affects expression

Bleomycin affects the expression of RPL6 protein

NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921

G

ribosomal protein S3a

increases expression

Bleomycin results in increased expression of RPS3A1 protein

NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055

G

S100 calcium binding protein A11

increases expression

Bleomycin results in increased expression of S100A11 protein

NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044

G

S100 calcium-binding protein A4

increases expression
multiple interactions

Bleomycin results in increased expression of S100A4 protein
andrographolide inhibits the reaction [Bleomycin results in increased expression of S100A4 protein]

PMID:25933445 PMID:31706003

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

S100 calcium binding protein A6

affects expression

Bleomycin affects the expression of S100A6 protein

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

S100 calcium binding protein A8

increases expression

Bleomycin results in increased expression of S100A8 protein

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

sphingosine-1-phosphate receptor 1

multiple interactions

[S1PR5 protein affects the susceptibility to Bleomycin] which affects the expression of S1PR1 protein

NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681

G

sphingosine-1-phosphate receptor 3

multiple interactions
increases expression

S1PR5 protein affects the reaction [Bleomycin results in increased expression of S1PR3 mRNA]

NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505

G

sphingosine-1-phosphate receptor 5

multiple interactions
affects response to substance

[S1PR5 protein affects the susceptibility to Bleomycin] which affects the expression of COMP protein; [S1PR5 protein affects the susceptibility to Bleomycin] which affects the expression of S1PR1 protein; S1PR5 protein affects the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; S1PR5 protein affects the reaction [Bleomycin results in increased expression of GATA3 mRNA]; S1PR5 protein affects the reaction [Bleomycin results in increased expression of S1PR3 mRNA]; S1PR5 protein affects the reaction [Bleomycin results in increased expression of SMAD7 mRNA]

NCBI chr 8:19,786,676...19,791,862
Ensembl chr 8:19,786,663...19,791,795

G

small Cajal body-specific RNA 15

affects expression

Bleomycin affects the expression of SCARNA15 mRNA

NCBI chr 1:135,484,620...135,484,683
Ensembl chr 1:135,484,559...135,484,685
Ensembl chr 1:135,484,559...135,484,685

G

secretoglobin family 1A member 1

decreases expression

Bleomycin results in decreased expression of SCGB1A1 protein

NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610

G

sterol carrier protein 2

increases expression

Bleomycin results in increased expression of SCP2 protein

NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287

G

serine carboxypeptidase 1

increases expression

Bleomycin results in increased expression of SCPEP1 protein

NCBI chr10:73,703,275...73,732,892
Ensembl chr10:73,703,278...73,732,850

G

signal peptide, CUB domain and EGF like domain containing 3

multiple interactions
decreases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of SCUBE3 mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of SCUBE3 mRNA]

NCBI chr20:6,199,182...6,231,100
Ensembl chr20:6,199,182...6,228,584

G

SEC14-like lipid binding 3

decreases expression

Bleomycin results in decreased expression of SEC14L3 protein

NCBI chr14:78,944,568...78,955,608
Ensembl chr14:78,912,750...78,956,099

G

selenium binding protein 1

decreases expression

Bleomycin results in decreased expression of SELENBP1 protein

NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594

G

serpin family B member 2

multiple interactions
increases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of SERPINB2 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of SERPINB2 mRNA]

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

serpin family E member 1

increases expression
multiple interactions
decreases expression

Bleomycin results in increased expression of SERPINE1 mRNA; Bleomycin results in increased expression of SERPINE1 protein
Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of SERPINE1 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 protein]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of SERPINE1 protein]

PMID:29175452 PMID:30825431 PMID:35716765

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serpin family H member 1

multiple interactions
increases expression

allyl sulfide inhibits the reaction [Bleomycin results in increased expression of SERPINH1 protein]

PMID:23656969 PMID:25933445

NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801

G

secreted frizzled-related protein 1

increases expression

Bleomycin results in increased expression of SFRP1 mRNA

NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286

G

surfactant protein A1

multiple interactions
increases expression
decreases expression

[Bleomycin co-treated with SFTPA1 protein polymorphism] results in increased expression of CXCL8 protein; [Bleomycin co-treated with SFTPA1 protein polymorphism] results in increased expression of TNF protein; Bleomycin promotes the reaction [[SFTPA1 protein binds to SFTPA2 protein] which results in increased expression of TNF protein]; calfactant inhibits the reaction [Bleomycin promotes the reaction [[SFTPA1 protein binds to SFTPA2 protein] which results in increased expression of TNF protein]]
Bleomycin results in increased expression of SFTPA1 protein
Bleomycin results in decreased expression of SFTPA1 mRNA

PMID:14617519 PMID:15782499 PMID:25933445

NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685

G

surfactant protein B

decreases expression
multiple interactions

Bleomycin results in decreased expression of SFTPB mRNA
[TNF protein affects the susceptibility to Bleomycin] which affects the expression of SFTPB protein

PMID:15782499 PMID:33647319

NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436

G

surfactant protein C

decreases expression

Bleomycin results in decreased expression of SFTPC mRNA; Bleomycin results in decreased expression of SFTPC protein

NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777

G

surfactant protein D

increases expression
multiple interactions
increases metabolic processing

Bleomycin results in increased expression of SFTPD mRNA; Bleomycin results in increased expression of SFTPD protein
[TNF protein affects the susceptibility to Bleomycin] which affects the expression of SFTPD protein; Bleomycin promotes the reaction [SFTPD protein binds to SFTPD protein binds to SFTPD protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Bleomycin results in increased metabolism of SFTPD protein]

PMID:11880309 PMID:25933445 PMID:26526764 PMID:33647319

NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927

G

sirtuin 1

decreases expression
multiple interactions

Bleomycin results in decreased expression of SIRT1 mRNA; Bleomycin results in decreased expression of SIRT1 protein
resveratrol inhibits the reaction [Bleomycin results in decreased expression of SIRT1 mRNA]; resveratrol inhibits the reaction [Bleomycin results in decreased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 12 member 1

increases expression

Bleomycin results in increased expression of SLC12A1 mRNA

NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899

G

solute carrier family 1 member 2

increases expression

Bleomycin results in increased expression of SLC1A2 mRNA

NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 25 member 4

decreases expression

Bleomycin results in decreased expression of SLC25A4 protein

NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733

G

solute carrier family 25 member 5

decreases expression

Bleomycin results in decreased expression of SLC25A5 protein

NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967

G

solute carrier family 6 member 12

increases expression

Bleomycin results in increased expression of SLC6A12 mRNA

NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750

G

solute carrier family 6 member 15

decreases expression
multiple interactions

Bleomycin results in decreased expression of SLC6A15 mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of SLC6A15 mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of SLC6A15 mRNA]

NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239

G

solute carrier family 7 member 1

decreases expression
multiple interactions

Bleomycin results in decreased expression of SLC7A1 mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of SLC7A1 mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of SLC7A1 mRNA]

NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849

G

solute carrier organic anion transporter family, member 2a1

increases response to substance
multiple interactions

SLCO2A1 gene mutant form results in increased susceptibility to Bleomycin
[SLCO2A1 gene mutant form results in increased susceptibility to Bleomycin] which results in increased expression of TNF mRNA; SLCO2A1 gene mutant form promotes the reaction [Bleomycin results in increased expression of CCL5 mRNA]; SLCO2A1 gene mutant form promotes the reaction [Bleomycin results in increased expression of IL1B mRNA]

NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546

G

solute carrier organic anion transporter family, member 2b1

multiple interactions

Bleomycin inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

secretory leukocyte peptidase inhibitor

increases expression
multiple interactions

Bleomycin results in increased expression of SLPI mRNA; Bleomycin results in increased expression of SLPI protein
Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of SLPI mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of SLPI mRNA]

PMID:26345256 PMID:30825431

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

SMAD family member 2

increases phosphorylation
increases expression
multiple interactions

Bleomycin results in increased phosphorylation of SMAD2 protein
Bleomycin results in increased expression of SMAD2 mRNA
yupingfeng inhibits the reaction [Bleomycin results in increased expression of SMAD2 mRNA]; yupingfeng inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein]
camostat inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein]; honokiol inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein]; Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein]

PMID:26599507 PMID:32032644 PMID:35187969 PMID:37898439

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

multiple interactions
increases phosphorylation
increases expression

Phytochemicals inhibits the reaction [Bleomycin results in increased expression of SMAD3 mRNA]
Bleomycin results in increased phosphorylation of SMAD3 protein
2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein]; honokiol inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein]; Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein]

PMID:26093215 PMID:27704718 PMID:32032644 PMID:35187969

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 7

decreases expression
multiple interactions
increases expression

Bleomycin results in decreased expression of SMAD7 mRNA
S1PR5 protein affects the reaction [Bleomycin results in increased expression of SMAD7 mRNA]

PMID:26093215 PMID:29033951

NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765

G

structural maintenance of chromosomes 1A

increases phosphorylation

Bleomycin results in increased phosphorylation of SMC1A protein

NCBI chr X:21,103,323...21,148,053
Ensembl chr X:21,103,282...21,148,056

G

small integral membrane protein 14

decreases expression

Bleomycin results in decreased expression of SMIM14 mRNA

NCBI chr14:42,783,361...42,829,762
Ensembl chr14:42,783,332...42,829,760

G

smoothelin

decreases expression
multiple interactions

Bleomycin results in decreased expression of SMTN mRNA
Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of SMTN mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of SMTN mRNA]

NCBI chr14:78,398,595...78,420,908
Ensembl chr14:78,397,778...78,420,886

G

small nucleolar RNA, H/ACA box 58

decreases expression

Bleomycin results in decreased expression of SNORA58 mRNA

NCBI chr 6:107,080,945...107,081,020
Ensembl chr 6:107,080,945...107,081,020

G

suppressor of cytokine signaling 1

decreases expression

Bleomycin results in decreased expression of SOCS1 mRNA

NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383

G

superoxide dismutase 1

increases expression
decreases activity
decreases expression
multiple interactions

Bleomycin results in increased expression of SOD1 protein
Bleomycin results in decreased activity of SOD1 protein
Bleomycin results in decreased expression of SOD1 protein
IL1A protein promotes the reaction [Bleomycin results in increased expression of SOD1 protein]; IL1B protein promotes the reaction [Bleomycin results in increased expression of SOD1 protein]; TNF protein promotes the reaction [Bleomycin results in increased expression of SOD1 protein]

PMID:8317554 PMID:25933445 PMID:30106319

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression
multiple interactions
decreases activity

Bleomycin results in increased expression of SOD2 protein
celastrol inhibits the reaction [Bleomycin results in decreased activity of SOD2 protein]
IL1A protein promotes the reaction [Bleomycin results in increased expression of SOD2 protein]; IL1B protein promotes the reaction [Bleomycin results in increased expression of SOD2 protein]; TNF protein promotes the reaction [Bleomycin results in increased expression of SOD2 protein]

PMID:8317554 PMID:26768587

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

secreted protein acidic and cysteine rich

increases response to substance

SPARC protein results in increased susceptibility to Bleomycin

NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396

G

SPARC like 1

decreases expression

Bleomycin results in decreased expression of SPARCL1 protein

NCBI chr14:5,632,816...5,663,866
Ensembl chr14:5,632,569...5,663,865

G

SPC25 component of NDC80 kinetochore complex

increases expression

Bleomycin results in increased expression of SPC25 mRNA

NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959

G

secreted phosphoprotein 1

increases expression

Bleomycin results in increased expression of SPP1 mRNA; Bleomycin results in increased expression of SPP1 protein

PMID:26345256 PMID:29175452

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

spectrin, alpha, non-erythrocytic 1

decreases expression

Bleomycin results in decreased expression of SPTAN1 protein

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

G

sulfiredoxin 1

increases expression

Bleomycin results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

somatostatin receptor 1

decreases expression

Bleomycin results in decreased expression of SSTR1 mRNA

NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802

G

somatostatin receptor 2

decreases expression

Bleomycin results in decreased expression of SSTR2 mRNA

NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351

G

somatostatin receptor 3

decreases expression

Bleomycin results in decreased expression of SSTR3 mRNA

NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769

G

ST14 transmembrane serine protease matriptase

multiple interactions

Bleomycin results in increased expression of and results in increased activity of ST14 protein

NCBI chr 8:29,540,805...29,581,704
Ensembl chr 8:29,540,811...29,581,517

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

decreases expression

Bleomycin results in decreased expression of ST3GAL5 mRNA

NCBI chr 4:104,134,613...104,192,558
Ensembl chr 4:104,134,613...104,192,558

G

signal transducer and activator of transcription 3

multiple interactions
increases expression

honokiol inhibits the reaction [Bleomycin results in increased expression of STAT3 protein modified form]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 6

multiple interactions
decreases response to substance

STAT6 protein affects the reaction [Bleomycin results in increased expression of RETNLA mRNA]
STAT6 gene mutant form results in decreased susceptibility to Bleomycin

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

serine/threonine kinase 11

increases expression
multiple interactions

Bleomycin results in increased expression of STK11 protein
Soot inhibits the reaction [Bleomycin results in increased expression of STK11 protein]

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

stathmin 1

increases expression

Bleomycin results in increased expression of STMN1 protein

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

synaptic vesicle glycoprotein 2b

increases expression

Bleomycin results in increased expression of SV2B mRNA

NCBI chr 1:128,978,471...129,152,479
Ensembl chr 1:128,978,473...129,152,479

G

tachykinin receptor 2

decreases expression

Bleomycin results in decreased expression of TACR2 mRNA

NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446

G

transgelin

increases expression

Bleomycin results in increased expression of TAGLN protein

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

transgelin 2

increases expression

Bleomycin results in increased expression of TAGLN2 protein

NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972

G

transaldolase 1

decreases expression

Bleomycin results in decreased expression of TALDO1 protein

NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974

G

T-box transcription factor 21

increases expression

Bleomycin results in increased expression of TBX21 mRNA

NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831

G

t-complex 1

multiple interactions

[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of TCP1 protein

NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839

G

terminal nucleotidyltransferase 4B

decreases expression

Bleomycin results in decreased expression of TENT4B mRNA

NCBI chr19:18,807,616...18,868,969
Ensembl chr19:18,807,525...18,869,537

G

telomerase reverse transcriptase

decreases response to substance

TERT gene mutant form results in decreased susceptibility to Bleomycin

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transferrin

increases expression

Bleomycin results in increased expression of TF protein

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transforming growth factor, beta 1

multiple interactions
increases expression
increases secretion

(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; 5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]]; [Bleomycin co-treated with Cannabidiol analog] results in decreased expression of TGFB1 mRNA; [Bleomycin co-treated with Rosiglitazone] results in decreased expression of TGFB1 mRNA; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Calcitriol inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; camostat inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; CCL11 protein promotes the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; CCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Diazoxide inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Grape Seed Extract inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; honokiol inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; lenabasum inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; loganin inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; morroniside inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide promotes the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Rosiglitazone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; SPL-334 inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]
yupingfeng inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; yupingfeng inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]
Bleomycin results in increased expression of TGFB1 mRNA; Bleomycin results in increased expression of TGFB1 protein
Bleomycin results in increased secretion of TGFB1 protein
andrographolide inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; angiotensin I (1-7) inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Berberine inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Hydrocortisone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Hydrocortisone inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; pachymic acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Resveratrol inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]

PMID:14609568 PMID:15541506 PMID:16115399 PMID:16314464 PMID:17035056 More...

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor beta 1 induced transcript 1

decreases expression

Bleomycin results in decreased expression of TGFB1I1 protein

NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080

G

transforming growth factor, beta 2

multiple interactions

[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta 3

increases expression
multiple interactions

Bleomycin results in increased expression of TGFB3 mRNA
CCL12 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]; HIF1A protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]; MMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

transforming growth factor, beta receptor 1

multiple interactions
increases expression

[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]
MIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]

PMID:28434932 PMID:28726637

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

transforming growth factor, beta receptor 2

multiple interactions

[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

TGFB-induced factor homeobox 2

increases expression

Bleomycin results in increased expression of TGIF2 mRNA

NCBI chr 3:145,333,152...145,348,599
Ensembl chr 3:145,333,418...145,348,596
Ensembl chr17:145,333,418...145,348,596

G

thrombospondin 1

increases expression

Bleomycin results in increased expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thrombospondin 2

increases expression
multiple interactions

Bleomycin results in increased expression of THBS2 protein
Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of THBS2 protein]; lenabasum inhibits the reaction [Bleomycin results in increased expression of THBS2 protein]

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

thimet oligopeptidase 1

decreases expression

Bleomycin results in decreased expression of THOP1 protein

NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275

G

thyroid hormone receptor beta

decreases expression

Bleomycin results in decreased expression of THRB mRNA

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

TIMP metallopeptidase inhibitor 1

increases expression
multiple interactions

Bleomycin results in increased expression of TIMP1 mRNA; Bleomycin results in increased expression of TIMP1 protein
Dexamethasone inhibits the reaction [Bleomycin results in increased expression of TIMP1 protein]; Grape Seed Extract inhibits the reaction [Bleomycin results in increased expression of TIMP1 protein]; honokiol inhibits the reaction [Bleomycin results in increased expression of TIMP1 protein]

PMID:26345256 PMID:28300665 PMID:32032644

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

toll-like receptor 1

decreases expression

Bleomycin results in decreased expression of TLR1 mRNA

NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125

G

transmembrane and coiled-coil domain family 3

decreases expression

Bleomycin results in decreased expression of TMCC3 mRNA

NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926

G

transmembrane protein 250

increases expression

Bleomycin results in increased expression of TMEM250 mRNA

NCBI chr 3:8,962,657...8,966,349
Ensembl chr 3:8,962,657...8,966,349

G

transmembrane protein 87A

increases expression

Bleomycin results in increased expression of TMEM87A mRNA

NCBI chr 3:107,307,726...107,353,571
Ensembl chr 3:107,307,726...107,353,551

G

tenascin C

increases expression
multiple interactions

Bleomycin results in increased expression of TNC mRNA; Bleomycin results in increased expression of TNC protein
Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of TNC protein]; lenabasum inhibits the reaction [Bleomycin results in increased expression of TNC protein]

PMID:26345256 PMID:30825431

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

multiple interactions
increases secretion
affects response to substance
increases expression

[Bleomycin co-treated with SFTPA1 protein polymorphism] results in increased expression of TNF protein; [Bleomycin co-treated with SFTPA2 protein polymorphism] results in increased expression of TNF protein; Bleomycin promotes the reaction [[SFTPA1 protein binds to SFTPA2 protein] which results in increased expression of TNF protein]; calfactant inhibits the reaction [Bleomycin promotes the reaction [[SFTPA1 protein binds to SFTPA2 protein] which results in increased expression of TNF protein]]; Ephedrine inhibits the reaction [Bleomycin results in increased secretion of TNF protein]; Ozone inhibits the reaction [[Bleomycin co-treated with SFTPA2 protein polymorphism] results in increased expression of TNF protein]; TNF protein promotes the reaction [Bleomycin results in increased expression of CAT protein]; TNF protein promotes the reaction [Bleomycin results in increased expression of SOD1 protein]; TNF protein promotes the reaction [Bleomycin results in increased expression of SOD2 protein]; yupingfeng inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]
TNF protein affects the susceptibility to Bleomycin
Bleomycin results in increased expression of TNF mRNA; Bleomycin results in increased expression of TNF protein
[Bleomycin co-treated with Tobacco Smoke Pollution] results in increased expression of TNF protein; Berberine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; celastrol inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Resveratrol inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Taurine inhibits the reaction [Bleomycin results in increased expression of TNF protein]
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased expression of TNF protein]; [SLCO2A1 gene mutant form results in increased susceptibility to Bleomycin] which results in increased expression of TNF mRNA; [TNF protein affects the susceptibility to Bleomycin] which affects the expression of SFTPB protein; [TNF protein affects the susceptibility to Bleomycin] which affects the expression of SFTPD protein; Calcitriol inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; CCR2 gene mutant form inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Enalapril inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; honokiol inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Oils, Volatile inhibits the reaction [Bleomycin results in increased expression of TNF protein]; pirinixic acid inhibits the reaction [Bleomycin results in increased expression of TNF protein]; PPARA protein affects the reaction [Bleomycin results in increased expression of TNF protein]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of TNF protein]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of TNF protein]; verlukast inhibits the reaction [Bleomycin results in increased expression of TNF protein]; zileuton inhibits the reaction [Bleomycin results in increased expression of TNF protein]

PMID:8317554 PMID:8473757 PMID:11350791 PMID:12003776 PMID:14609568 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

increases response to substance
increases expression

TNFRSF1A results in increased susceptibility to Bleomycin
Bleomycin results in increased expression of TNFRSF1A mRNA

PMID:12003776 PMID:36087614

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

increases expression
increases response to substance

Bleomycin results in increased expression of TNFRSF1B protein
TNFRSF1B results in increased susceptibility to Bleomycin

PMID:12003776 PMID:15371238

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

TNF superfamily member 11

decreases expression

Bleomycin results in decreased expression of TNFSF11 mRNA

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

TNF superfamily member 4

increases expression

Bleomycin results in increased expression of TNFSF4 mRNA

NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788

G

tumor protein p53

increases expression
multiple interactions
increases phosphorylation
increases response to substance

Bleomycin results in increased expression of TRP53 protein
Bleomycin results in increased expression of TP53 mRNA
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Bleomycin promotes the reaction [Resveratrol results in increased phosphorylation of TP53 protein]]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Bleomycin results in increased phosphorylation of TP53 protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Resveratrol promotes the reaction [Bleomycin results in increased phosphorylation of TP53 protein]]; Bleomycin promotes the reaction [Polyphenols results in increased expression of TP53 mRNA]; Bleomycin promotes the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; Bleomycin promotes the reaction [Tea results in increased expression of TP53 mRNA]; Polyphenols promotes the reaction [Bleomycin results in increased expression of TP53 mRNA]; Resveratrol promotes the reaction [Bleomycin results in increased phosphorylation of TP53 protein]; Tea promotes the reaction [Bleomycin results in increased expression of TP53 mRNA]
TP53 protein results in increased susceptibility to Bleomycin

PMID:9683175 PMID:20135637 PMID:24933654 PMID:26800624

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tropomyosin 1

increases expression

Bleomycin results in increased expression of TPM1 protein

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

G

tropomyosin 3

increases expression

Bleomycin results in increased expression of TPM3 protein

NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013

G

tropomyosin 4

increases expression

Bleomycin results in increased expression of TPM4 protein

NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984

G

tubulin polymerization-promoting protein family member 3

decreases expression

Bleomycin results in decreased expression of TPPP3 protein

NCBI chr19:33,345,897...33,349,610
Ensembl chr19:33,345,898...33,349,577

G

Tnf receptor-associated factor 2

decreases expression
increases expression

Bleomycin results in decreased expression of TRAF2 protein
Bleomycin results in increased expression of TRAF2 mRNA

PMID:15371238 PMID:36087614

NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538

G

Traf3 interacting protein 2

multiple interactions

Calcitriol inhibits the reaction [Bleomycin results in increased phosphorylation of ACT1 protein]

NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667

G

tripartite motif-containing 28

increases phosphorylation

Bleomycin results in increased phosphorylation of TRIM28 protein

NCBI chr 1:73,652,441...73,659,388
Ensembl chr 1:73,652,709...73,659,380

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions

TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of CXCL1 protein]; TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of CXCL2 protein]; TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of IL1B protein]; TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of TNF protein]

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

G

thyroid stimulating hormone receptor

decreases expression

Bleomycin results in decreased expression of TSHR mRNA

NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538

G

tubulin, alpha 1C

decreases expression

Bleomycin results in decreased expression of TUBA1C protein

NCBI chr 7:130,192,050...130,199,655
Ensembl chr 7:130,192,016...130,199,647
Ensembl chr X:130,192,016...130,199,647

G

tubulin, beta 2A class IIa

decreases expression

Bleomycin results in decreased expression of TUBB2A protein
Bleomycin results in decreased expression of TUBB2A mRNA

PMID:25933445 PMID:33770205

NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714

G

tubulin, beta 4B class IVb

decreases expression

Bleomycin results in decreased expression of TUBB4B protein

NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296

G

twist family bHLH transcription factor 1

increases expression

Bleomycin results in increased expression of TWIST1 protein

NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653

G

thymidine phosphorylase

increases expression
multiple interactions

Bleomycin results in increased expression of TYMP protein
Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of TYMP protein]

NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

UDP-glucose ceramide glucosyltransferase

decreases expression

Bleomycin results in decreased expression of UGCG mRNA

NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393

G

unc-51 like autophagy activating kinase 1

increases expression
multiple interactions

Bleomycin results in increased expression of ULK1 protein modified form
Soot inhibits the reaction [Bleomycin results in increased expression of ULK1 protein modified form]

NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966

G

ubiquinol-cytochrome c reductase core protein 1

decreases expression

Bleomycin results in decreased expression of UQCRC1 protein

NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480

G

ubiquinol-cytochrome c reductase hinge protein

increases expression

Bleomycin results in increased expression of UQCRHL protein

NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242

G

vav guanine nucleotide exchange factor 1

multiple interactions
increases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in increased expression of VAV1 mRNA]; lenabasum inhibits the reaction [Bleomycin results in increased expression of VAV1 mRNA]

NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937

G

vinculin

decreases expression

Bleomycin results in decreased expression of VCL protein

NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606

G

vascular endothelial growth factor A

increases expression

Bleomycin results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor B

increases expression
multiple interactions

Bleomycin results in increased expression of VEGFB protein
Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of VEGFB protein]; lenabasum inhibits the reaction [Bleomycin results in increased expression of VEGFB protein]

NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944

G

vimentin

increases expression
multiple interactions
affects expression
decreases expression

Bleomycin results in increased expression of VIM protein
Ephedrine inhibits the reaction [Bleomycin results in increased expression of VIM mRNA]; Ephedrine inhibits the reaction [Bleomycin results in increased expression of VIM protein]
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM protein]; MIR100HG mRNA affects the reaction [Bleomycin results in increased expression of VIM mRNA]; MIR100HG mRNA affects the reaction [Bleomycin results in increased expression of VIM protein]
Bleomycin results in increased expression of VIM mRNA; Bleomycin results in increased expression of VIM protein
Bleomycin affects the expression of VIM protein
Bleomycin results in decreased expression of VIM mRNA

PMID:25933445 PMID:34425168 PMID:35267148 PMID:35472619 PMID:37126650 More...

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

von Willebrand factor

multiple interactions
decreases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of VWF protein]

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

G

Wnt inhibitory factor 1

multiple interactions
decreases expression

Cannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of WIF1 mRNA]; lenabasum inhibits the reaction [Bleomycin results in decreased expression of WIF1 mRNA]

NCBI chr 7:56,548,060...56,618,364
Ensembl chr 7:56,548,053...56,618,360

G

Wnt family member 1

increases expression

Bleomycin results in increased expression of WNT1 mRNA

NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651

G

Wnt family member 10A

increases expression

Bleomycin results in increased expression of WNT10A mRNA

NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400

G

Wnt family member 9A

increases expression

Bleomycin results in increased expression of WNT9A mRNA

NCBI chr10:44,094,140...44,121,134
Ensembl chr10:44,094,140...44,121,133

G

X-ray repair cross complementing 1

affects response to substance
decreases response to substance

XRCC1 gene polymorphism affects the susceptibility to Bleomycin
XRCC1 results in decreased susceptibility to Bleomycin

PMID:12082022 PMID:20705543

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

G

X-ray repair cross complementing 5

affects response to substance

XRCC5 protein affects the susceptibility to Bleomycin

NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018

G

YES proto-oncogene 1, Src family tyrosine kinase

decreases expression

Bleomycin results in decreased expression of YES1 mRNA

NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreases expression

Bleomycin results in decreased expression of YWHAB protein

NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105

G

zinc finger protein X-linked

increases expression

Bleomycin results in increased expression of ZFX mRNA

NCBI chr X:58,804,690...58,853,155
Ensembl chr X:58,804,691...58,853,265

bleomycin A5

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

abhydrolase domain containing 10, depalmitoylase

decreases expression

bleomycetin results in decreased expression of ABHD10 mRNA

NCBI chr11:55,081,273...55,095,044
Ensembl chr11:55,081,049...55,107,866

G

ALG12, alpha-1,6-mannosyltransferase

decreases expression

bleomycetin results in decreased expression of ALG12 mRNA

NCBI chr 7:119,895,112...119,909,488
Ensembl chr 7:119,895,120...119,909,458

G

alpha-methylacyl-CoA racemase

decreases expression

bleomycetin results in decreased expression of AMACR mRNA

NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255

G

ARF GTPase 4

decreases expression

bleomycetin results in decreased expression of ARF4 mRNA

NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261

G

beta-2 microglobulin

decreases expression

bleomycetin results in decreased expression of B2M mRNA

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

bone morphogenetic protein 2

increases expression

bleomycetin results in increased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

carbonic anhydrase 9

increases expression
multiple interactions
decreases response to substance

bleomycetin results in increased expression of CA9 mRNA; bleomycetin results in increased expression of CA9 protein
CA9 protein inhibits the reaction [bleomycetin results in increased activity of CASP3 protein]
CA9 protein results in decreased susceptibility to bleomycetin

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

G

CAS1 domain containing 1

decreases expression

bleomycetin results in decreased expression of CASD1 mRNA

NCBI chr 4:32,659,196...32,739,228
Ensembl chr 4:32,658,748...32,739,202

G

caspase 1

decreases expression

bleomycetin results in decreased expression of CASP1 mRNA

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases activity

Acetazolamide promotes the reaction [bleomycetin results in increased activity of CASP3 protein]; CA9 protein inhibits the reaction [bleomycetin results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cadherin-related family member 5

decreases expression

bleomycetin results in decreased expression of CDHR5 mRNA

NCBI chr 1:196,373,110...196,381,609
Ensembl chr 1:196,373,112...196,381,543

G

cytochrome c oxidase subunit 7B

decreases expression

bleomycetin results in decreased expression of COX7B mRNA

NCBI chr X:71,083,486...71,089,733
Ensembl chr X:71,083,456...71,089,732

G

cullin 4A

increases expression

bleomycetin results in increased expression of CUL4A mRNA

NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330

G

DNA-damage-inducible transcript 4

increases expression

bleomycetin results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105