CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | chalcones |
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Accession: | CHEBI:23086
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browse the term
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Definition: | A ketone that is 1,3-diphenylpropenone (benzylideneacetophenone), ArCH=CH(=O)Ar, and its derivatives formed by substitution. |
Synonyms: | related_synonym: | chalconoid; chalconoids |
| xref: | KEGG:C15589 |
| xref_mesh: | MESH:D047188 |
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Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
BCL2 protein inhibits the reaction [Chalcones analog results in increased expression of BAX protein] Chalcones analog results in increased expression of BAX mRNA; Chalcones analog results in increased expression of BAX protein |
CTD |
PMID:30576621 PMID:32856275 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO |
Chalcones analog results in decreased expression of BCL2 mRNA; Chalcones analog results in decreased expression of BCL2 protein; Chalcones results in decreased expression of BCL2 protein BCL2 protein inhibits the reaction [Chalcones analog results in decreased expression of BID protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP8 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP4 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP6 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP7 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of PARP1 protein]; BCL2 protein inhibits the reaction [Chalcones analog results in increased expression of BAX protein] |
CTD |
PMID:23562496 PMID:30576621 PMID:32856275 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bid |
BH3 interacting domain death agonist |
multiple interactions decreases expression |
ISO |
BCL2 protein inhibits the reaction [Chalcones analog results in decreased expression of BID protein] |
CTD |
PMID:30576621 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Birc2 |
baculoviral IAP repeat-containing 2 |
affects binding |
ISO |
Chalcones analog binds to BIRC2 protein |
CTD |
PMID:32856275 |
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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Casp3 |
caspase 3 |
multiple interactions increases expression |
ISO |
BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP3 protein]; Chalcones analog results in increased cleavage of and results in increased activity of CASP3 protein Chalcones analog results in increased expression of CASP3 mRNA |
CTD |
PMID:30576621 PMID:32856275 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp4 |
caspase 4 |
increases cleavage multiple interactions |
ISO |
Chalcones analog results in increased cleavage of CASP4 protein BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP4 protein] |
CTD |
PMID:30576621 |
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NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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Casp6 |
caspase 6 |
multiple interactions increases cleavage |
ISO |
BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP6 protein] |
CTD |
PMID:30576621 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp7 |
caspase 7 |
increases cleavage multiple interactions |
ISO |
Chalcones analog results in increased cleavage of CASP7 protein BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of CASP7 protein] |
CTD |
PMID:30576621 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8 |
caspase 8 |
multiple interactions increases expression |
ISO |
BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP8 protein]; Chalcones analog results in increased cleavage of and results in increased activity of CASP8 protein Chalcones analog results in increased expression of CASP8 mRNA |
CTD |
PMID:30576621 PMID:32856275 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9 |
caspase 9 |
multiple interactions increases expression |
ISO |
BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of and results in increased activity of CASP9 protein]; Chalcones analog results in increased cleavage of and results in increased activity of CASP9 protein Chalcones analog results in increased expression of CASP9 mRNA |
CTD |
PMID:30576621 PMID:32856275 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat |
catalase |
increases activity |
EXP |
Chalcones analog results in increased activity of CAT protein |
CTD |
PMID:23963778 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Chalcones analog results in decreased expression of CDK4 mRNA |
CTD |
PMID:32856275 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Gsr |
glutathione-disulfide reductase |
increases activity |
EXP |
Chalcones analog results in increased activity of GSR protein |
CTD |
PMID:23963778 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Il6 |
interleukin 6 |
multiple interactions |
EXP |
Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] |
CTD |
PMID:22410118 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Keap1 |
Kelch-like ECH-associated protein 1 |
decreases expression |
EXP |
Chalcones analog results in decreased expression of KEAP1 protein |
CTD |
PMID:23963778 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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Mmp1 |
matrix metallopeptidase 1 |
decreases expression |
ISO |
Chalcones analog results in decreased expression of MMP1 mRNA |
CTD |
PMID:32856275 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp9 |
matrix metallopeptidase 9 |
decreases expression multiple interactions |
ISO |
Chalcones results in decreased expression of MMP9 mRNA Chalcones results in decreased expression of and results in decreased activity of MMP9 protein |
CTD |
PMID:23562496 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo |
myeloperoxidase |
multiple interactions |
EXP |
Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] |
CTD |
PMID:22410118 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mt-co1 |
mitochondrially encoded cytochrome c oxidase I |
decreases expression |
ISO |
Chalcones analog results in decreased expression of COX1 protein |
CTD |
PMID:32856275 |
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NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression |
EXP |
Chalcones analog results in increased expression of NFE2L2 protein |
CTD |
PMID:23963778 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
EXP |
Chalcones analog results in increased expression of NQO1 protein |
CTD |
PMID:23963778 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
BCL2 protein inhibits the reaction [Chalcones analog results in increased cleavage of PARP1 protein] |
CTD |
PMID:30576621 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
multiple interactions |
EXP |
Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PECAM1 protein] |
CTD |
PMID:22410118 |
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NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid affects the localization of RELA protein] |
CTD |
PMID:22410118 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
Chalcones inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] |
CTD |
PMID:18720166 PMID:22410118 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53 |
tumor protein p53 |
increases expression |
ISO |
Chalcones analog results in increased expression of TP53 mRNA |
CTD |
PMID:32856275 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
EXP |
Chalcones analog results in increased expression of UGT1A1 protein |
CTD |
PMID:23963778 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
Chalcones analog results in decreased expression of VEGFA protein |
CTD |
PMID:32856275 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:38521250 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of BAX protein |
CTD |
PMID:38521250 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of BCL2 protein |
CTD |
PMID:38521250 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3 |
caspase 3 |
increases cleavage multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP3 protein Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP3 protein] |
CTD |
PMID:38521250 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9 |
caspase 9 |
increases cleavage |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP9 protein |
CTD |
PMID:38521250 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccnb1 |
cyclin B1 |
increases expression |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CCNB1 protein |
CTD |
PMID:38521250 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Cdc25c |
cell division cycle 25C |
increases expression |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CDC25C protein |
CTD |
PMID:38521250 |
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NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdk1 |
cyclin-dependent kinase 1 |
increases expression |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CDK1 protein |
CTD |
PMID:38521250 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of CDKN1A protein |
CTD |
PMID:38521250 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases expression |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of CDKN1B protein |
CTD |
PMID:38521250 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cycs |
cytochrome c, somatic |
increases expression |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CYCS protein |
CTD |
PMID:38521250 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA] |
CTD |
PMID:31029725 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA] 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA; 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein |
CTD |
PMID:31029725 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein] |
CTD |
PMID:31029725 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6 |
interleukin 6 |
multiple interactions increases expression |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA] |
CTD |
PMID:31029725 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased lipidation of and results in increased localization of MAP1LC3B protein; Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased lipidation of and results in increased localization of MAP1LC3B protein] |
CTD |
PMID:38521250 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:31029725 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:31029725 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased phosphorylation of MAPK8 protein 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:31029725 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of MTOR protein Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of MTOR protein] |
CTD |
PMID:38521250 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein] |
CTD |
PMID:31029725 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of and affects the stability of NFKBIA protein] |
CTD |
PMID:31029725 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2 |
nitric oxide synthase 2 |
increases expression multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA] |
CTD |
PMID:31029725 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA] |
CTD |
PMID:31029725 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of PARP1 protein] |
CTD |
PMID:38521250 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions decreases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of PIK3R1 protein] |
CTD |
PMID:38521250 |
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NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Sqstm1 |
sequestosome 1 |
increases expression |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of SQSTM1 protein |
CTD |
PMID:38521250 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA] |
CTD |
PMID:31029725 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of naringenin chalcone |
CTD |
PMID:14557274 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of naringenin chalcone |
CTD |
PMID:14557274 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
increases response to substance multiple interactions |
ISO |
ABCG2 protein results in increased susceptibility to 2',5'-dihydroxychalcone 2',5'-dihydroxychalcone promotes the reaction [ABCG2 protein results in increased export of Glutathione] |
CTD |
PMID:20332504 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of 2',5'-dihydroxychalcone |
CTD |
PMID:14557274 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of 2',5'-dihydroxychalcone |
CTD |
PMID:14557274 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Bid |
BH3 interacting domain death agonist |
increases cleavage multiple interactions |
ISO |
2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of BID protein Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of BID protein] |
CTD |
PMID:30408460 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Casp2 |
caspase 2 |
increases cleavage multiple interactions |
ISO |
2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP2 protein Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP2 protein] |
CTD |
PMID:30408460 |
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NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP3 protein |
CTD |
PMID:30408460 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
increases cleavage multiple interactions |
ISO |
2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP7 protein Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP7 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP7 protein] |
CTD |
PMID:30408460 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp9 |
caspase 9 |
multiple interactions increases cleavage |
ISO |
Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP9 protein] |
CTD |
PMID:30408460 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
2-hydroxy-3',5,5'-trimethoxychalcone results in increased expression of CDKN1A protein |
CTD |
PMID:30408460 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
2-hydroxy-3',5,5'-trimethoxychalcone results in increased expression of GADD45A protein |
CTD |
PMID:30408460 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
H2ax |
H2A.X variant histone |
increases phosphorylation multiple interactions |
ISO |
2-hydroxy-3',5,5'-trimethoxychalcone results in increased phosphorylation of H2AX protein Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased phosphorylation of H2AX protein] |
CTD |
PMID:30408460 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of PARP1 protein] |
CTD |
PMID:30408460 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased expression of TP53 protein] |
CTD |
PMID:30408460 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity multiple interactions |
ISO |
2'-hydroxychalcone results in decreased activity of CYP1A1 protein 2'-hydroxychalcone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:15596260 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity multiple interactions |
ISO |
2'-hydroxychalcone results in decreased activity of CYP1B1 protein 2'-hydroxychalcone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:15596260 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
2'-hydroxychalcone results in increased expression of HMOX1 protein |
CTD |
PMID:23942037 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
2',4'-dihydroxychalcone results in decreased expression of BIRC5 mRNA |
CTD |
PMID:20471467 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
2',4'-dihydroxychalcone results in increased activity of CASP3 protein |
CTD |
PMID:20471467 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of 2',4'-dihydroxychalcone |
CTD |
PMID:14557274 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of 2',4'-dihydroxychalcone |
CTD |
PMID:14557274 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
4'-hydroxychalcone binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
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NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
4'-hydroxychalcone binds to SHBG protein |
CTD |
PMID:25349334 |
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NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions increases expression |
ISO |
[4'-methoxychalcone analog co-treated with TNF protein] results in increased expression of ADIPOQ mRNA 4'-methoxychalcone analog results in increased expression of ADIPOQ mRNA |
CTD |
PMID:28528971 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
4'-methoxychalcone analog inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] |
CTD |
PMID:28528971 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions increases expression |
ISO |
4'-methoxychalcone analog inhibits the reaction [TNF protein results in decreased expression of FABP4 mRNA] 4'-methoxychalcone analog results in increased expression of FABP4 mRNA |
CTD |
PMID:28528971 |
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NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Fasn |
fatty acid synthase |
increases expression multiple interactions |
ISO |
4'-methoxychalcone analog results in increased expression of FASN mRNA 4'-methoxychalcone analog inhibits the reaction [TNF protein results in decreased expression of FASN mRNA] |
CTD |
PMID:28528971 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
4'-methoxychalcone analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA] |
CTD |
PMID:28528971 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions increases expression |
ISO |
4'-methoxychalcone analog inhibits the reaction [TNF protein results in decreased expression of PPARG mRNA]; 4'-methoxychalcone analog results in increased expression of and results in increased activity of PPARG protein 4'-methoxychalcone analog results in increased expression of PPARG mRNA |
CTD |
PMID:28528971 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
4'-methoxychalcone analog inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] |
CTD |
PMID:28528971 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Slc2a4 |
solute carrier family 2 member 4 |
increases expression |
ISO |
4'-methoxychalcone analog results in increased expression of SLC2A4 mRNA |
CTD |
PMID:28528971 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
4'-methoxychalcone analog inhibits the reaction [TNF protein results in decreased expression of FABP4 mRNA]; 4'-methoxychalcone analog inhibits the reaction [TNF protein results in decreased expression of FASN mRNA]; 4'-methoxychalcone analog inhibits the reaction [TNF protein results in decreased expression of PPARG mRNA]; 4'-methoxychalcone analog inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; 4'-methoxychalcone analog inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; 4'-methoxychalcone analog inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; [4'-methoxychalcone analog co-treated with TNF protein] results in increased expression of ADIPOQ mRNA |
CTD |
PMID:28528971 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
4-hydroxychalcone binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
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NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Ar |
androgen receptor |
affects binding |
EXP |
4-hydroxychalcone binds to AR protein |
CTD |
PMID:14565775 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity affects chemical synthesis |
ISO EXP |
4-hydroxychalcone results in decreased activity of CYP1A1 protein CYP1A1 protein affects the chemical synthesis of 4-hydroxychalcone |
CTD |
PMID:15596260 PMID:15863696 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
affects chemical synthesis |
EXP |
CYP1A2 protein affects the chemical synthesis of 4-hydroxychalcone |
CTD |
PMID:15863696 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
4-hydroxychalcone results in decreased activity of CYP1B1 protein |
CTD |
PMID:15596260 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
affects chemical synthesis |
EXP |
CYP2C6 protein affects the chemical synthesis of 4-hydroxychalcone |
CTD |
PMID:15863696 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
4-hydroxychalcone binds to SHBG protein |
CTD |
PMID:25349334 |
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NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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G |
Sod2 |
superoxide dismutase 2 |
increases expression |
ISO |
bavachalcone results in increased expression of SOD2 mRNA; bavachalcone results in increased expression of SOD2 protein |
CTD |
PMID:25766656 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
butein results in decreased phosphorylation of AKT1 protein Acetylcysteine inhibits the reaction [butein results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:20696233 PMID:35130734 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
butein results in increased expression of BAX protein |
CTD |
PMID:11055382 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
butein results in decreased expression of BCL2 protein |
CTD |
PMID:11055382 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
butein results in decreased expression of BCL2L1 protein |
CTD |
PMID:11055382 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
butein results in increased activity of CASP3 protein Acetylcysteine inhibits the reaction [butein results in increased activity of CASP3 protein] |
CTD |
PMID:24931875 PMID:35130734 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
butein results in increased activity of CASP8 protein |
CTD |
PMID:35130734 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity |
ISO |
butein results in increased activity of CASP9 protein |
CTD |
PMID:35130734 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
butein affects the reaction [IL6 protein affects the expression of CDH1 protein] |
CTD |
PMID:35130734 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Dio2 |
iodothyronine deiodinase 2 |
decreases activity |
ISO |
butein results in decreased activity of DIO2 protein |
CTD |
PMID:17327447 |
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NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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G |
Gpx4 |
glutathione peroxidase 4 |
decreases expression |
ISO |
butein results in decreased expression of GPX4 protein |
CTD |
PMID:35130734 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
[butein results in increased expression of HMOX1 protein] inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]; [butein results in increased expression of HMOX1 protein] which results in decreased susceptibility to Hydrogen Peroxide; [tin protoporphyrin IX results in decreased expression of and results in decreased activity of HMOX1 protein] inhibits the reaction [butein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]]; butein results in increased expression of and results in increased activity of HMOX1 protein; pyrazolanthrone inhibits the reaction [butein results in increased expression of HMOX1 protein] |
CTD |
PMID:23318726 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
butein affects the reaction [IL6 protein affects the expression of CDH1 protein]; butein affects the reaction [IL6 protein affects the expression of MMP2 protein]; butein affects the reaction [IL6 protein affects the expression of MMP9 protein]; butein affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein] |
CTD |
PMID:35130734 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases lipidation |
ISO |
Acetylcysteine inhibits the reaction [butein results in increased lipidation of MAP1LC3B protein]; MK 2206 promotes the reaction [butein results in increased lipidation of MAP1LC3B protein]; pyrazolanthrone inhibits the reaction [butein results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:35130734 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation multiple interactions |
ISO |
butein results in increased phosphorylation of MAPK8 protein Acetylcysteine inhibits the reaction [butein results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:35130734 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
butein affects the reaction [IL6 protein affects the expression of MMP2 protein] |
CTD |
PMID:35130734 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [butein results in decreased expression of MMP9 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [butein results in decreased expression of MMP9 protein]; Bortezomib promotes the reaction [butein results in decreased expression of MMP9 protein]; butein affects the reaction [IL6 protein affects the expression of MMP9 protein]; butein inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; prolinedithiocarbamate promotes the reaction [butein results in decreased expression of MMP9 protein] butein results in decreased expression of MMP9 mRNA; butein results in decreased expression of MMP9 protein |
CTD |
PMID:20696233 PMID:35130734 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation multiple interactions |
ISO |
butein results in decreased phosphorylation of MTOR protein Acetylcysteine inhibits the reaction [butein results in decreased phosphorylation of MTOR protein] |
CTD |
PMID:35130734 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization |
ISO |
butein affects the localization of NFE2L2 protein |
CTD |
PMID:23318726 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
affects localization |
ISO |
butein affects the localization of NFKB1 protein |
CTD |
PMID:20696233 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
butein results in increased activity of NR1I2 protein |
CTD |
PMID:29933105 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
butein results in increased cleavage of PARP1 protein |
CTD |
PMID:24931875 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pttg1 |
PTTG1 regulator of sister chromatid separation, securin |
decreases expression decreases response to substance |
ISO |
butein results in decreased expression of PTTG1 protein PTTG1 protein results in decreased susceptibility to butein |
CTD |
PMID:24931875 |
|
NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization |
ISO |
butein affects the localization of RELA protein |
CTD |
PMID:20696233 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sirt1 |
sirtuin 1 |
increases activity |
ISO |
butein results in increased activity of SIRT1 protein |
CTD |
PMID:17327447 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
butein affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein] |
CTD |
PMID:35130734 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
butein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; butein inhibits the reaction [TNF protein results in increased expression of MMP9 protein] |
CTD |
PMID:20696233 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
butein results in decreased expression of VEGFA mRNA |
CTD |
PMID:20696233 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Ache |
acetylcholinesterase |
increases activity |
EXP |
cardamonin results in increased activity of ACHE protein |
CTD |
PMID:31034797 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
cardamonin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of BCL2 protein] |
CTD |
PMID:28966130 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
cardamonin results in increased cleavage of CASP3 protein |
CTD |
PMID:37268255 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
multiple interactions |
EXP |
cardamonin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased activity of CAT protein] |
CTD |
PMID:28966130 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
cardamonin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:22696397 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
cardamonin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:22696397 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
cardamonin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] |
CTD |
PMID:22696397 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
cardamonin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NFKB1 protein] |
CTD |
PMID:28966130 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
cardamonin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NOS2 mRNA] |
CTD |
PMID:28966130 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
EXP |
cardamonin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of NOS3 mRNA] |
CTD |
PMID:28966130 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
cardamonin results in increased cleavage of PARP1 protein |
CTD |
PMID:37268255 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
cardamonin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] cardamonin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of TNF protein] |
CTD |
PMID:22696397 PMID:28966130 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
Chalcone binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Ar |
androgen receptor |
affects binding |
EXP |
Chalcone binds to AR protein |
CTD |
PMID:14565775 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Car1 |
carbonic anhydrase 1 |
decreases activity |
ISO |
Chalcone results in decreased activity of CA1 protein |
CTD |
PMID:30431690 |
|
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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G |
Car2 |
carbonic anhydrase 2 |
decreases activity |
ISO |
Chalcone results in decreased activity of CA2 protein |
CTD |
PMID:30431690 |
|
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions |
ISO |
Chalcone results in increased cleavage of CASP3 protein MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP3 protein] |
CTD |
PMID:20620131 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases cleavage multiple interactions |
ISO |
Chalcone results in increased cleavage of CASP8 protein MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein] |
CTD |
PMID:20620131 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases cleavage multiple interactions |
ISO |
Chalcone results in increased cleavage of CASP9 protein MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP9 protein] |
CTD |
PMID:20620131 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases hydroxylation |
EXP |
CYP1A1 protein results in increased hydroxylation of Chalcone |
CTD |
PMID:15863696 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases hydroxylation |
EXP |
CYP1A2 protein results in increased hydroxylation of Chalcone |
CTD |
PMID:15863696 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
increases hydroxylation |
EXP |
CYP2C6 protein results in increased hydroxylation of Chalcone |
CTD |
PMID:15863696 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
increases hydroxylation |
EXP |
CYP3A23-3A1 protein results in increased hydroxylation of Chalcone |
CTD |
PMID:15863696 |
|
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
Chalcone analog results in increased expression of GCLM mRNA; Chalcone analog results in increased expression of GCLM protein |
CTD |
PMID:31299238 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Hat1 |
histone acetyltransferase 1 |
decreases activity |
ISO |
Chalcone analog results in decreased activity of HAT1 protein |
CTD |
PMID:22155221 |
|
NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] |
CTD |
PMID:22155221 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22155221 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:22155221 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:22155221 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:22155221 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
affects response to substance multiple interactions |
ISO |
MYC protein affects the susceptibility to Chalcone Chalcone promotes the reaction [MYC protein results in increased abundance of Reactive Oxygen Species]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP3 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP8 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of CASP9 protein]; MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein] |
CTD |
PMID:20620131 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
Chalcone analog results in decreased ubiquitination of and results in decreased degradation of and affects the localization of NFE2L2 protein; NFE2L2 promotes the reaction [Chalcone analog results in increased abundance of Glutathione] |
CTD |
PMID:31299238 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:22155221 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2] which results in increased abundance of Nitric Oxide]; Chalcone analog inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to NOS2 promoter]]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:22155221 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
Chalcone analog results in increased expression of NQO1 mRNA; Chalcone analog results in increased expression of NQO1 protein |
CTD |
PMID:31299238 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
Chalcone results in increased cleavage of PARP1 protein MYC protein affects the susceptibility to [Chalcone results in increased cleavage of PARP1 protein] |
CTD |
PMID:20620131 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression |
ISO |
Chalcone analog results in increased expression of PPARG mRNA |
CTD |
PMID:28528971 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ptgr1 |
prostaglandin reductase 1 |
multiple interactions |
EXP |
[PTGR1 protein co-treated with NADP] affects the reduction of Chalcone |
CTD |
PMID:11524419 |
|
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased phosphorylation of RELA protein] which results in increased acetylation of RELA protein]; Chalcone analog inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to NOS2 promoter]]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] |
CTD |
PMID:22155221 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
Chalcone binds to SHBG protein |
CTD |
PMID:25349334 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chalcone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:22155221 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
flavokawain A inhibits the reaction [Lipopolysaccharides affects the localization of [JUN protein binds to FOS protein]] |
CTD |
PMID:23727179 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
CTD |
PMID:23727179 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] |
CTD |
PMID:23727179 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
flavokawain A inhibits the reaction [Lipopolysaccharides affects the localization of [JUN protein binds to FOS protein]]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein] |
CTD |
PMID:23727179 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
flavokawain A inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] |
CTD |
PMID:23727179 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
flavokawain A inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:23727179 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
flavokawain A inhibits the reaction [Lipopolysaccharides promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:23727179 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
flavokawain A inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] |
CTD |
PMID:23727179 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; flavokawain A inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:23727179 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Adgre1 |
adhesion G protein-coupled receptor E1 |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of ADGRE1 protein] |
CTD |
PMID:38583725 |
|
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
flavokawain B results in decreased phosphorylation of AKT1 protein TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:30025493 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
ISO |
4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of ATF4 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of DDIT3 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATF4 protein affects the reaction [flavokawain B results in increased expression of TRIB3 protein] |
CTD |
PMID:30025493 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atg5 |
autophagy related 5 |
multiple interactions affects response to substance |
ISO |
[ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of CDKN1A protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of GLB1 protein; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MAP1LC3B protein modified form; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MKI67 protein; ATG5 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] |
CTD |
PMID:30025493 |
|
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Atg7 |
autophagy related 7 |
affects response to substance multiple interactions |
ISO |
ATG7 protein affects the susceptibility to flavokawain B [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; ATG7 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] |
CTD |
PMID:30025493 |
|
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in increased cleavage of BAX protein]; flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of BAX protein] |
CTD |
PMID:38583725 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in decreased expression of BCL2 protein] |
CTD |
PMID:38583725 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of CASP3 protein |
CTD |
PMID:30025493 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of CCL2 mRNA] |
CTD |
PMID:38583725 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
[ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of CDKN1A protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of CDKN1A protein |
CTD |
PMID:30025493 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of DDIT3 protein]; ATF4 protein affects the reaction [flavokawain B results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] |
CTD |
PMID:30025493 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases phosphorylation |
ISO |
flavokawain B results in increased phosphorylation of EIF2AK3 protein |
CTD |
PMID:30025493 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation |
ISO |
flavokawain B results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:30025493 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Glb1 |
galactosidase, beta 1 |
multiple interactions increases expression |
ISO |
[ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of GLB1 protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of GLB1 protein flavokawain B results in increased expression of GLB1 protein |
CTD |
PMID:30025493 |
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NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
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G |
H2ax |
H2A.X variant histone |
increases phosphorylation |
ISO |
flavokawain B results in increased phosphorylation of H2AX protein |
CTD |
PMID:30025493 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
flavokawain B results in increased expression of HSPA5 protein |
CTD |
PMID:30025493 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA] |
CTD |
PMID:38583725 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 mRNA] |
CTD |
PMID:38583725 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of IL1B mRNA] |
CTD |
PMID:38583725 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il33 |
interleukin 33 |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL33 mRNA] |
CTD |
PMID:38583725 |
|
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of IL6 mRNA]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased secretion of IL6 protein] |
CTD |
PMID:38583725 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases expression |
ISO |
3-methyladenine inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; 4-phenylbutyric acid inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; [ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MAP1LC3B protein modified form; [Chloroquine co-treated with flavokawain B] results in increased expression of MAP1LC3B protein modified form; ATF4 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG5 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; ATG7 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; DDIT3 protein affects the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form] |
CTD |
PMID:30025493 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAP3K7 protein]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased phosphorylation of MAP3K7 protein] |
CTD |
PMID:38583725 |
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NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
ISO |
[ATG5 protein affects the susceptibility to flavokawain B] which affects the expression of MKI67 protein; [Chloroquine co-treated with flavokawain B] results in decreased expression of MKI67 protein |
CTD |
PMID:30025493 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases phosphorylation |
ISO |
TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of MTOR protein] |
CTD |
PMID:30025493 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate promotes the reaction [TLR2 protein binds to MYD88 protein]] |
CTD |
PMID:38583725 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in decreased expression of NFKBIA protein]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in decreased expression of NFKBIA protein] |
CTD |
PMID:38583725 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[ATG5 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [ATG7 protein affects the susceptibility to flavokawain B] which affects the cleavage of PARP1 protein; [flavokawain B co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein |
CTD |
PMID:30025493 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased phosphorylation of RELA protein] |
CTD |
PMID:38583725 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation multiple interactions |
ISO |
flavokawain B results in decreased phosphorylation of RPS6KB1 protein TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:30025493 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Sqstm1 |
sequestosome 1 |
increases expression |
ISO |
flavokawain B results in increased expression of SQSTM1 protein |
CTD |
PMID:30025493 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Tlr2 |
toll-like receptor 2 |
multiple interactions affects binding |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate promotes the reaction [TLR2 protein binds to MYD88 protein]] flavokawain B binds to TLR2 protein |
CTD |
PMID:38583725 |
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NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased expression of TNF mRNA]; flavokawain B inhibits the reaction [Pam(3)CSK(4) peptide results in increased secretion of TNF protein] |
CTD |
PMID:38583725 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Trib3 |
tribbles pseudokinase 3 |
multiple interactions increases expression |
ISO |
ATF4 protein affects the reaction [flavokawain B results in increased expression of TRIB3 protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of AKT1 protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of MTOR protein]; TRIB3 protein affects the reaction [flavokawain B results in decreased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:30025493 |
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NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
flavokawain B inhibits the reaction [Dextran Sulfate results in increased expression of VCAM1 mRNA] |
CTD |
PMID:38583725 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
ISO |
Enzymes and Coenzymes inhibits the reaction [isobavachalcone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; isobavachalcone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid] |
CTD |
PMID:35101544 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Ces1d |
carboxylesterase 1D |
decreases activity |
ISO |
isobavachalcone results in decreased activity of CES1 protein |
CTD |
PMID:26560012 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity multiple interactions |
EXP |
isobavachalcone results in decreased activity of CYP2E1 protein isobavachalcone inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol] |
CTD |
PMID:31870919 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases activity |
EXP |
isobavachalcone inhibits the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone] isobavachalcone results in decreased activity of CYP3A4 protein |
CTD |
PMID:31870919 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
isobavachalcone results in increased cleavage of PARP1 protein |
CTD |
PMID:30890322 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
isoliquiritigenin binds to AFP protein |
CTD |
PMID:23013281 |
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NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene affects the localization of AHR protein] |
CTD |
PMID:25110319 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases response to substance multiple interactions decreases phosphorylation |
ISO |
AKT1 protein modified form results in decreased susceptibility to isoliquiritigenin isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein] 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein] isoliquiritigenin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:23747687 PMID:25094029 PMID:27117918 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Arg1 |
arginase 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 protein] |
CTD |
PMID:25026504 |
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NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
isoliquiritigenin results in increased expression of BAX mRNA; isoliquiritigenin results in increased expression of BAX protein |
CTD |
PMID:11055382 PMID:27702603 PMID:38311047 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases phosphorylation |
ISO |
isoliquiritigenin results in decreased phosphorylation of BCL2 protein |
CTD |
PMID:23747687 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression decreases phosphorylation |
ISO |
isoliquiritigenin results in decreased expression of BCL2L1 protein isoliquiritigenin results in decreased phosphorylation of BCL2L1 protein |
CTD |
PMID:11055382 PMID:15729620 PMID:23747687 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of BIRC2 protein |
CTD |
PMID:15729620 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of BIRC3 protein |
CTD |
PMID:15729620 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases activity increases cleavage |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP3 protein isoliquiritigenin results in increased expression of CASP3 mRNA isoliquiritigenin results in increased activity of CASP3 protein |
CTD |
PMID:15729620 PMID:16158945 PMID:23747687 PMID:25094029 PMID:38311047 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
isoliquiritigenin results in increased activity of CASP8 protein |
CTD |
PMID:16158945 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression increases activity increases cleavage |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP9 protein isoliquiritigenin results in increased expression of CASP9 mRNA isoliquiritigenin results in increased activity of CASP9 protein |
CTD |
PMID:16158945 PMID:23747687 PMID:25094029 PMID:38311047 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions increases expression |
EXP ISO |
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] isoliquiritigenin results in increased expression of CAT mRNA isoliquiritigenin inhibits the reaction [Paroxetine results in decreased activity of CAT protein] |
CTD |
PMID:25450236 PMID:36740106 PMID:38311047 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cckar |
cholecystokinin A receptor |
multiple interactions increases expression |
ISO |
fulvestrant inhibits the reaction [isoliquiritigenin results in increased expression of CCKAR mRNA] |
CTD |
PMID:27702603 |
|
NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747
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G |
Ccnd2 |
cyclin D2 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CCND2 mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Ccne2 |
cyclin E2 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CCNE2 mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
isoliquiritigenin results in increased expression of CDKN1A mRNA; isoliquiritigenin results in increased expression of CDKN1A protein |
CTD |
PMID:27702603 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CDKN1B mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn1c |
cyclin-dependent kinase inhibitor 1C |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CDKN1C mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of CEBPA protein] |
CTD |
PMID:27117918 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of CHUK protein] |
CTD |
PMID:18295200 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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|
G |
Ctsb |
cathepsin B |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CTSB protein |
CTD |
PMID:38311047 |
|
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
|
|
G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CXCL10 mRNA] |
CTD |
PMID:25026504 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:27773742 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CYP19A1 mRNA |
CTD |
PMID:27773742 |
|
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:25110319 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions decreases activity |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] isoliquiritigenin results in decreased activity of CYP1A2 protein |
CTD |
PMID:25110319 PMID:29753067 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions increases expression |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] isoliquiritigenin results in increased expression of CYP1B1 mRNA |
CTD |
PMID:25110319 PMID:26134484 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
isoliquiritigenin results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein] |
CTD |
PMID:25450236 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
isoliquiritigenin results in decreased activity of CYP3A4 protein |
CTD |
PMID:29753067 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA] |
CTD |
PMID:37561086 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of ERN1 mRNA] |
CTD |
PMID:37561086 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
|
|
G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of FABP4 protein] |
CTD |
PMID:27117918 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Foxo3 |
forkhead box O3 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of FOXO3 mRNA |
CTD |
PMID:38311047 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
Gadd45gip1 |
GADD45G interacting protein 1 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of GADD45GIP1 mRNA |
CTD |
PMID:27702603 |
|
NCBI chr19:23,320,662...23,323,211
Ensembl chr19:23,320,159...23,323,236
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of GFAP protein] |
CTD |
PMID:19834288 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [Paroxetine results in increased activity of GPT protein] |
CTD |
PMID:36740106 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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|
G |
Gpx1 |
glutathione peroxidase 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of GPX1 mRNA |
CTD |
PMID:38311047 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Cisplatin results in decreased activity of GSR protein] |
CTD |
PMID:37561086 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 protein] |
CTD |
PMID:37561086 |
|
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of HMOX1 protein |
CTD |
PMID:23942037 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of HSD17B1 mRNA |
CTD |
PMID:27773742 |
|
NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
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|
G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
multiple interactions |
EXP |
[isoliquiritigenin co-treated with Cisplatin] results in increased expression of HSP90B1 protein |
CTD |
PMID:37561086 |
|
NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
EXP |
[Cisplatin co-treated with isoliquiritigenin] results in increased expression of HSPA5 mRNA isoliquiritigenin results in increased expression of HSPA5 mRNA |
CTD |
PMID:37561086 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IFNG protein]; isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites] isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:23942037 PMID:25026504 PMID:26134484 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL10 protein] |
CTD |
PMID:25026504 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il1rn |
interleukin 1 receptor antagonist |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein] |
CTD |
PMID:25026504 |
|
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] |
CTD |
PMID:18295200 PMID:25026504 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of CEBPA protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of FABP4 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of PPARG protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] |
CTD |
PMID:27117918 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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|
G |
Insr |
insulin receptor |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] |
CTD |
PMID:27117918 |
|
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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|
G |
Itgam |
integrin subunit alpha M |
multiple interactions increases expression |
ISO |
TEMPOL-H inhibits the reaction [isoliquiritigenin results in increased expression of ITGAM protein] |
CTD |
PMID:24369695 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of MAP1LC3B protein |
CTD |
PMID:38311047 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:18295200 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:18295200 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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|
G |
Melk |
maternal embryonic leucine zipper kinase |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of MELK mRNA; isoliquiritigenin results in decreased expression of MELK protein |
CTD |
PMID:36893906 |
|
NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937
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G |
Mfn2 |
mitofusin 2 |
increases expression |
EXP |
isoliquiritigenin results in increased expression of MFN2 protein |
CTD |
PMID:37561086 |
|
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of MKI67 mRNA; isoliquiritigenin results in decreased expression of MKI67 protein |
CTD |
PMID:27702603 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases expression |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein] isoliquiritigenin results in decreased expression of MMP2 mRNA; isoliquiritigenin results in decreased expression of MMP2 protein |
CTD |
PMID:25094029 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein] isoliquiritigenin results in decreased expression of MMP9 mRNA; isoliquiritigenin results in decreased expression of MMP9 protein |
CTD |
PMID:25094029 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mrc1 |
mannose receptor, C type 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein] |
CTD |
PMID:25026504 |
|
NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of NFE2L2 mRNA |
CTD |
PMID:38311047 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of NFKB1 protein] |
CTD |
PMID:18295200 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression multiple interactions decreases phosphorylation |
ISO |
isoliquiritigenin results in increased expression of NFKBIA protein isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of and results in increased phosphorylation of NFKBIA protein] isoliquiritigenin results in decreased phosphorylation of NFKBIA protein |
CTD |
PMID:15729620 PMID:18295200 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of NOS2 protein] |
CTD |
PMID:18295200 PMID:19834288 PMID:25026504 PMID:26134484 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of NQO1 protein |
CTD |
PMID:26473469 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity increases expression |
ISO |
isoliquiritigenin results in increased activity of NR1I2 protein isoliquiritigenin results in increased expression of NR1I2 mRNA |
CTD |
PMID:29933105 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
isoliquiritigenin results in increased cleavage of PARP1 protein benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of PARP1 protein] |
CTD |
PMID:23747687 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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|
G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
decreases phosphorylation |
ISO |
isoliquiritigenin results in decreased phosphorylation of PDK1 protein |
CTD |
PMID:25094029 |
|
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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|
G |
Pla2g5 |
phospholipase A2, group V |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of PLA2G5 mRNA |
CTD |
PMID:23747687 |
|
NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
|
|
G |
Pou5f1 |
POU class 5 homeobox 1 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of POU5F1 mRNA |
CTD |
PMID:38311047 |
|
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of PPARG protein] |
CTD |
PMID:27117918 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Ptger4 |
prostaglandin E receptor 4 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of PTGER4 mRNA; isoliquiritigenin results in decreased expression of PTGER4 protein |
CTD |
PMID:25094029 |
|
NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
|
|
G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of PTGS1 mRNA |
CTD |
PMID:25094029 |
|
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression multiple interactions |
ISO EXP |
isoliquiritigenin results in decreased expression of PTGS2 mRNA isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] |
CTD |
PMID:18295200 PMID:23747687 PMID:25026504 PMID:25450236 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein] |
CTD |
PMID:27117918 |
|
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization multiple interactions decreases activity |
ISO |
isoliquiritigenin affects the localization of RELA protein isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] isoliquiritigenin results in decreased activity of RELA protein |
CTD |
PMID:15729620 PMID:18295200 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sirt1 |
sirtuin 1 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of SIRT1 mRNA |
CTD |
PMID:38311047 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions decreases activity |
ISO |
isoliquiritigenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose] isoliquiritigenin results in decreased activity of SLC2A1 protein |
CTD |
PMID:14642735 |
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NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein] |
CTD |
PMID:27117918 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Slc6a3 |
solute carrier family 6 member 3 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] |
CTD |
PMID:19834288 |
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NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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G |
Slco1c1 |
solute carrier organic anion transporter family, member 1c1 |
multiple interactions decreases activity |
EXP |
[isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate |
CTD |
PMID:32259555 |
|
NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289
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G |
Sod2 |
superoxide dismutase 2 |
affects response to substance increases expression |
ISO |
SOD2 protein affects the susceptibility to isoliquiritigenin isoliquiritigenin results in increased expression of SOD2 mRNA |
CTD |
PMID:23526725 PMID:38311047 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Star |
steroidogenic acute regulatory protein |
increases expression |
ISO |
isoliquiritigenin results in increased expression of STAR mRNA |
CTD |
PMID:27773742 |
|
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:25026504 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TGFB1 protein] |
CTD |
PMID:25026504 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TNF protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein] isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA] isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] |
CTD |
PMID:18295200 PMID:25026504 PMID:25450236 PMID:26134484 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of TRP53 mRNA |
CTD |
PMID:27702603 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of isoliquiritigenin |
CTD |
PMID:14557274 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of isoliquiritigenin |
CTD |
PMID:14557274 |
|
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Xbp1 |
X-box binding protein 1 |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of XBP1 mRNA] |
CTD |
PMID:37561086 |
|
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:26134484 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of AKT1 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
ISO |
licochalcone A results in increased expression of BAD mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
licochalcone A results in increased expression of BAK1 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
licochalcone A results in increased expression of BAX mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
licochalcone A results in increased expression of BBC3 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
ISO |
licochalcone A results in increased expression of BCL2 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
licochalcone A results in decreased expression of BIRC5 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions increases expression |
ISO |
licochalcone A results in increased cleavage of CASP3 protein HSPA5 protein affects the reaction [licochalcone A results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [licochalcone A results in increased cleavage of CASP3 protein] licochalcone A results in increased expression of CASP3 mRNA |
CTD |
PMID:30055311 PMID:30983163 PMID:38308464 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions increases expression increases cleavage |
ISO |
SB 203580 inhibits the reaction [licochalcone A results in increased cleavage of CASP8 protein] licochalcone A results in increased expression of CASP8 mRNA |
CTD |
PMID:30055311 PMID:30983163 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases cleavage multiple interactions |
ISO |
licochalcone A results in increased cleavage of CASP9 protein SB 203580 inhibits the reaction [licochalcone A results in increased cleavage of CASP9 protein] |
CTD |
PMID:30983163 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccn1 |
cellular communication network factor 1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of CCN1 mRNA |
CTD |
PMID:34845814 |
|
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G |
Ccn2 |
cellular communication network factor 2 |
decreases expression |
ISO |
licochalcone A results in decreased expression of CCN2 mRNA |
CTD |
PMID:34845814 |
|
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of CCNB1 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
increases expression |
ISO |
licochalcone A results in increased expression of CCND1 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of CDK1 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
licochalcone A results in increased expression of CDKN1A mRNA |
CTD |
PMID:30055311 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
licochalcone A results in decreased activity of CYP1A2 protein |
CTD |
PMID:26100226 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions decreases expression |
ISO |
licochalcone A inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]; licochalcone A inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] licochalcone A results in decreased expression of CYP1B1 mRNA |
CTD |
PMID:26134484 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
licochalcone A results in decreased activity of CYP2C19 protein |
CTD |
PMID:26100226 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
licochalcone A results in decreased activity of CYP2C8 protein |
CTD |
PMID:26100226 |
|
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
affects activity |
ISO |
licochalcone A affects the activity of CYP2D6 protein |
CTD |
PMID:26100226 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
affects activity |
ISO |
licochalcone A affects the activity of CYP2E1 protein |
CTD |
PMID:26100226 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
licochalcone A results in decreased activity of CYP3A4 protein |
CTD |
PMID:26100226 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
HSPA5 protein affects the reaction [licochalcone A results in increased cleavage of DDIT3 protein] licochalcone A results in increased expression of DDIT3 protein |
CTD |
PMID:38308464 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dyrk1a |
dual specificity tyrosine phosphorylation regulated kinase 1A |
decreases activity |
ISO |
licochalcone A results in decreased activity of DYRK1A protein |
CTD |
PMID:31838052 |
|
NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases expression |
ISO |
licochalcone A results in increased expression of EIF2AK3 protein |
CTD |
PMID:38308464 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
increases expression |
ISO |
licochalcone A results in increased expression of ERN1 protein |
CTD |
PMID:38308464 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
licochalcone A results in increased expression of FAS mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
ISO |
licochalcone A results in increased expression of HSPA5 protein HSPA5 protein affects the reaction [licochalcone A results in increased cleavage of CASP3 protein]; HSPA5 protein affects the reaction [licochalcone A results in increased cleavage of DDIT3 protein]; HSPA5 protein affects the reaction [licochalcone A results in increased cleavage of PARP1 protein] |
CTD |
PMID:38308464 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:26134484 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; licochalcone A inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone] |
CTD |
PMID:16354411 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Lats1 |
large tumor suppressor kinase 1 |
decreases expression increases expression |
ISO |
licochalcone A results in decreased expression of LATS1 protein licochalcone A results in increased expression of LATS1 protein modified form |
CTD |
PMID:34845814 |
|
NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640
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G |
Map2k4 |
mitogen activated protein kinase kinase 4 |
decreases phosphorylation multiple interactions |
ISO |
licochalcone A results in decreased phosphorylation of MAP2K4 protein licochalcone A promotes the reaction [Sorafenib results in decreased phosphorylation of MAP2K4 protein]; Sorafenib promotes the reaction [licochalcone A results in decreased phosphorylation of MAP2K4 protein] |
CTD |
PMID:30187994 |
|
NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
licochalcone A results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:30983163 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
licochalcone A results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:30983163 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases expression decreases phosphorylation |
ISO |
licochalcone A promotes the reaction [Sorafenib results in decreased phosphorylation of MAPK8 protein]; Sorafenib promotes the reaction [licochalcone A results in decreased phosphorylation of MAPK8 protein] licochalcone A results in increased expression of MAPK8 mRNA |
CTD |
PMID:30055311 PMID:30187994 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
decreases phosphorylation multiple interactions |
ISO |
licochalcone A results in decreased phosphorylation of MAPK9 protein licochalcone A promotes the reaction [Sorafenib results in decreased phosphorylation of MAPK9 protein]; Sorafenib promotes the reaction [licochalcone A results in decreased phosphorylation of MAPK9 protein] |
CTD |
PMID:30187994 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:26134484 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
licochalcone A results in increased expression of NQO1 protein |
CTD |
PMID:26473469 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
licochalcone A results in increased cleavage of PARP1 protein HSPA5 protein affects the reaction [licochalcone A results in increased cleavage of PARP1 protein] |
CTD |
PMID:30983163 PMID:38308464 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pes1 |
pescadillo ribosomal biogenesis factor 1 |
affects expression decreases expression multiple interactions |
ISO |
licochalcone A affects the expression of PES1 protein modified form licochalcone A results in decreased expression of PES1 mRNA licochalcone A results in decreased expression of and affects the localization of PES1 protein |
CTD |
PMID:34845814 |
|
NCBI chr14:78,850,754...78,867,134
Ensembl chr14:78,850,709...78,867,134
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G |
Plau |
plasminogen activator, urokinase |
multiple interactions decreases expression |
ISO |
licochalcone A promotes the reaction [Sorafenib results in decreased expression of PLAU protein]; Sorafenib promotes the reaction [licochalcone A results in decreased expression of PLAU protein] |
CTD |
PMID:30187994 |
|
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Prkce |
protein kinase C, epsilon |
decreases expression |
ISO |
licochalcone A results in decreased expression of PRKCE mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of RPS6KB1 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Slco1c1 |
solute carrier organic anion transporter family, member 1c1 |
multiple interactions decreases activity |
EXP |
[licochalcone A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [licochalcone A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate |
CTD |
PMID:32259555 |
|
NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289
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G |
Stk4 |
serine/threonine kinase 4 |
increases expression decreases expression multiple interactions |
ISO |
licochalcone A results in increased expression of STK4 protein modified form licochalcone A results in decreased expression of STK4 protein XMU-MP-1 inhibits the reaction [licochalcone A results in increased expression of STK4 protein modified form] |
CTD |
PMID:34845814 |
|
NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:26134484 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf25 |
TNF receptor superfamily member 25 |
increases expression |
ISO |
licochalcone A results in increased expression of TNFRSF25 mRNA |
CTD |
PMID:30055311 |
|
NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
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|
G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein] |
CTD |
PMID:26875642 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein] |
CTD |
PMID:26875642 |
|
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Trifluoperazine results in increased activity of UGT1A4 protein] |
CTD |
PMID:26875642 |
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NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein] |
CTD |
PMID:26875642 |
|
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]; licochalcone A inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol] |
CTD |
PMID:26875642 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b1 |
UDP glucuronosyltransferase 2 family, polypeptide B1 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B17 protein] |
CTD |
PMID:26875642 |
|
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
multiple interactions |
ISO |
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein] |
CTD |
PMID:26875642 |
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NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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G |
Wee1 |
WEE1 G2 checkpoint kinase |
increases expression |
ISO |
licochalcone A results in increased expression of WEE1 mRNA |
CTD |
PMID:30055311 |
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NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
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G |
Wwtr1 |
WW domain containing transcription regulator 1 |
decreases expression |
ISO |
licochalcone A results in decreased expression of WWTR1 protein |
CTD |
PMID:34845814 |
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NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
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|
G |
Yap1 |
Yes1 associated transcriptional regulator |
decreases expression multiple interactions |
ISO |
licochalcone A results in decreased expression of YAP1 mRNA; licochalcone A results in decreased expression of YAP1 protein XMU-MP-1 inhibits the reaction [licochalcone A results in increased expression of YAP1 protein modified form] |
CTD |
PMID:34845814 |
|
NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
decreases expression |
ISO |
licochalcone B results in decreased expression of ABCA1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abca8 |
ATP binding cassette subfamily A member 8 |
decreases expression |
ISO |
licochalcone B results in decreased expression of ABCA8 mRNA |
CTD |
PMID:33647349 |
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NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
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G |
Abca8a |
ATP-binding cassette, subfamily A (ABC1), member 8a |
increases expression |
ISO |
licochalcone B results in increased expression of ABCA10 mRNA |
CTD |
PMID:33647349 |
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NCBI chr10:95,002,334...95,072,315
Ensembl chr10:95,002,334...95,072,375
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
increases expression |
ISO |
licochalcone B results in increased expression of ABCB4 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Ache |
acetylcholinesterase |
increases expression |
ISO |
licochalcone B results in increased expression of ACHE mRNA |
CTD |
PMID:33647349 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Acsbg1 |
acyl-CoA synthetase bubblegum family member 1 |
increases expression |
ISO |
licochalcone B results in increased expression of ACSBG1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:54,991,294...55,047,276
Ensembl chr 8:54,991,296...55,047,391
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G |
Acta1 |
actin, alpha 1, skeletal muscle |
increases expression |
ISO |
licochalcone B results in increased expression of ACTA1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
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G |
Actn3 |
actinin alpha 3 |
increases expression |
ISO |
licochalcone B results in increased expression of ACTN3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012
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|
G |
Adamts5 |
ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
decreases expression |
ISO |
licochalcone B results in decreased expression of ADAMTS5 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205
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G |
Adap1 |
ArfGAP with dual PH domains 1 |
increases expression |
ISO |
licochalcone B results in increased expression of ADAP1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr12:15,323,913...15,376,110
Ensembl chr12:15,324,209...15,380,831
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G |
Adat3 |
adenosine deaminase, tRNA-specific 3 |
increases expression |
ISO |
licochalcone B results in increased expression of ADAT3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:9,109,070...9,113,673
Ensembl chr 7:9,101,187...9,115,340
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G |
Adgrg3 |
adhesion G protein-coupled receptor G3 |
decreases expression |
ISO |
licochalcone B results in decreased expression of ADGRG3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr19:9,972,425...10,001,118
Ensembl chr19:9,972,430...10,001,123
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G |
Adgrl2 |
adhesion G protein-coupled receptor L2 |
decreases expression |
ISO |
licochalcone B results in decreased expression of ADGRL2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:237,696,055...238,327,141
Ensembl chr 2:237,696,056...238,327,141
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G |
Adm |
adrenomedullin |
increases expression |
ISO |
licochalcone B results in increased expression of ADM mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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G |
Adra1d |
adrenoceptor alpha 1D |
increases expression |
ISO |
licochalcone B results in increased expression of ADRA1D mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
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G |
Adra2b |
adrenoceptor alpha 2B |
increases expression |
ISO |
licochalcone B results in increased expression of ADRA2B mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355
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G |
Adrb2 |
adrenoceptor beta 2 |
increases expression |
ISO |
licochalcone B results in increased expression of ADRB2 mRNA |
CTD |
PMID:33647349 |
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NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Afmid |
arylformamidase |
increases expression |
ISO |
licochalcone B results in increased expression of AFMID mRNA |
CTD |
PMID:33647349 |
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NCBI chr10:103,046,129...103,061,718
Ensembl chr10:103,046,180...103,061,718
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G |
Agl |
amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase |
decreases expression |
ISO |
licochalcone B results in decreased expression of AGL mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:204,705,053...204,760,966
Ensembl chr 2:204,705,053...204,760,828
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G |
Akap5 |
A-kinase anchoring protein 5 |
decreases expression |
ISO |
licochalcone B results in decreased expression of AKAP5 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
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|
G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases expression |
ISO |
licochalcone B results in increased expression of AKR1B10 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
ISO |
licochalcone B results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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|
G |
Alg9 |
ALG9, alpha-1,2-mannosyltransferase |
decreases expression |
ISO |
licochalcone B results in decreased expression of ALG9 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:51,117,057...51,188,790
Ensembl chr 8:51,119,365...51,182,261
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G |
Alkal2 |
ALK and LTK ligand 2 |
increases expression |
ISO |
licochalcone B results in increased expression of ALKAL2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 6:47,495,645...47,505,235
Ensembl chr 6:47,495,782...47,505,234
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|
G |
Alox12 |
arachidonate 12-lipoxygenase, 12S type |
increases expression |
ISO |
licochalcone B results in increased expression of ALOX12 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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|
G |
Aloxe3 |
arachidonate epidermal lipoxygenase 3 |
increases expression |
ISO |
licochalcone B results in increased expression of ALOXE3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:53,830,219...53,854,328
Ensembl chr10:53,831,264...53,854,328
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|
G |
Ang |
angiogenin |
decreases expression |
ISO |
licochalcone B results in decreased expression of ANG mRNA |
CTD |
PMID:33647349 |
|
NCBI chr15:24,312,711...24,323,361
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|
G |
Ankrd1 |
ankyrin repeat domain 1 |
increases expression |
ISO |
licochalcone B results in increased expression of ANKRD1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
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|
G |
Ap3b2 |
adaptor related protein complex 3 subunit beta 2 |
increases expression |
ISO |
licochalcone B results in increased expression of AP3B2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:135,412,580...135,445,191
Ensembl chr 1:135,412,580...135,445,191
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|
G |
Ap5z1 |
adaptor related protein complex 5 subunit zeta 1 |
increases expression |
ISO |
licochalcone B results in increased expression of AP5Z1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr12:12,093,834...12,109,043
Ensembl chr12:12,093,834...12,108,511
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|
G |
Apbb1 |
amyloid beta precursor protein binding family B member 1 |
increases expression |
ISO |
licochalcone B results in increased expression of APBB1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:159,896,889...159,920,505
Ensembl chr 1:159,896,880...159,920,627
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|
G |
Apobr |
apolipoprotein B receptor |
decreases expression |
ISO |
licochalcone B results in decreased expression of APOBR mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:181,169,019...181,173,206
Ensembl chr 1:181,168,916...181,173,528
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|
G |
Apoe |
apolipoprotein E |
increases expression |
ISO |
licochalcone B results in increased expression of APOE mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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|
G |
Arc |
activity-regulated cytoskeleton-associated protein |
increases expression |
ISO |
licochalcone B results in increased expression of ARC mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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|
G |
Arhgef33 |
Rho guanine nucleotide exchange factor 33 |
increases expression |
ISO |
licochalcone B results in increased expression of ARHGEF33 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 6:14,582,922...14,715,014
Ensembl chr 6:14,551,495...14,725,292
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|
G |
Arl4c |
ARF like GTPase 4C |
increases expression |
ISO |
licochalcone B results in increased expression of ARL4C mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513
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G |
Arl4d |
ARF like GTPase 4D |
increases expression |
ISO |
licochalcone B results in increased expression of ARL4D mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836
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|
G |
Arl6ip4 |
ARF like GTPase 6 interacting protein 4 |
increases expression |
ISO |
licochalcone B results in increased expression of ARL6IP4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr12:32,479,623...32,481,768
Ensembl chr12:32,479,625...32,481,799
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|
G |
Arnt2 |
aryl hydrocarbon receptor nuclear translocator 2 |
decreases expression |
ISO |
licochalcone B results in decreased expression of ARNT2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153
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G |
Arpin |
actin-related protein 2/3 complex inhibitor |
decreases expression |
ISO |
licochalcone B results in decreased expression of ARPIN mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:133,864,288...133,873,124
Ensembl chr 1:133,864,265...133,873,124
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|
G |
Asic4 |
acid sensing ion channel subunit family member 4 |
increases expression |
ISO |
licochalcone B results in increased expression of ASIC4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:76,941,532...76,962,900
Ensembl chr 9:76,941,532...76,962,900
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|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
licochalcone B results in increased expression of ASNS mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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|
G |
Atcay |
ATCAY kinesin light chain interacting caytaxin |
increases expression |
ISO |
licochalcone B results in increased expression of ATCAY mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:8,487,763...8,511,527
Ensembl chr 7:8,487,763...8,512,663
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
licochalcone B results in increased expression of ATF3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atg9b |
autophagy related 9B |
increases expression |
ISO |
licochalcone B results in increased expression of ATG9B mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 4:10,784,934...10,793,832
Ensembl chr 4:10,786,114...10,793,651
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G |
Atm |
ATM serine/threonine kinase |
increases phosphorylation |
ISO |
licochalcone B results in increased phosphorylation of ATM protein |
CTD |
PMID:35948134 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Atp13a4 |
ATPase 13A4 |
increases expression |
ISO |
licochalcone B results in increased expression of ATP13A4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr11:71,222,196...71,359,933
Ensembl chr11:71,226,161...71,359,933
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|
G |
Atp1a3 |
ATPase Na+/K+ transporting subunit alpha 3 |
increases expression |
ISO |
licochalcone B results in increased expression of ATP1A3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
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|
G |
Atp6v0c |
ATPase H+ transporting V0 subunit C |
increases expression |
ISO |
licochalcone B results in increased expression of ATP6V0C mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:13,196,204...13,202,580
Ensembl chr10:13,196,204...13,201,500
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|
G |
Atp9a |
ATPase phospholipid transporting 9A (putative) |
decreases expression |
ISO |
licochalcone B results in decreased expression of ATP9A mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818
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G |
Aurkc |
aurora kinase C |
increases expression |
ISO |
licochalcone B results in increased expression of AURKC mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:66,843,653...66,849,775
Ensembl chr 1:66,843,653...66,864,386
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|
G |
B3gnt4 |
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 |
increases expression |
ISO |
licochalcone B results in increased expression of B3GNT4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr12:33,070,221...33,073,904
Ensembl chr12:33,060,416...33,073,854
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|
G |
B4galnt3 |
beta-1,4-N-acetyl-galactosaminyl transferase 3 |
increases expression |
ISO |
licochalcone B results in increased expression of B4GALNT3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 4:153,409,019...153,509,019
Ensembl chr 4:153,409,004...153,509,321
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|
G |
Bag3 |
BAG cochaperone 3 |
increases expression |
ISO |
licochalcone B results in increased expression of BAG3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
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|
G |
Baiap2 |
BAR/IMD domain containing adaptor protein 2 |
increases expression |
ISO |
licochalcone B results in increased expression of BAIAP2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134
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|
G |
Baiap3 |
BAI1-associated protein 3 |
increases expression |
ISO |
licochalcone B results in increased expression of BAIAP3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:14,260,269...14,273,019
Ensembl chr10:14,260,269...14,273,019
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|
G |
Bambi |
BMP and activin membrane-bound inhibitor |
increases expression |
ISO |
licochalcone B results in increased expression of BAMBI mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
licochalcone B results in increased expression of BAX protein |
CTD |
PMID:24384411 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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|
G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
licochalcone B results in increased expression of BBC3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
licochalcone B results in decreased expression of BCL2 protein |
CTD |
PMID:24384411 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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|
G |
Bex1 |
brain expressed X-linked 1 |
increases expression |
ISO |
licochalcone B results in increased expression of BEX2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr X:99,219,014...99,220,518
Ensembl chr X:99,219,014...99,220,958
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|
G |
Bicdl2 |
BICD family like cargo adaptor 2 |
increases expression |
ISO |
licochalcone B results in increased expression of BICDL2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:12,691,610...12,700,049
Ensembl chr10:12,691,610...12,700,049
|
|
G |
Bik |
BCL2-interacting killer |
increases expression |
ISO |
licochalcone B results in increased expression of BIK mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
licochalcone B results in decreased expression of BIRC5 protein |
CTD |
PMID:24384411 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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|
G |
Blvrb |
biliverdin reductase B |
increases expression |
ISO |
licochalcone B results in increased expression of BLVRB mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375
|
|
G |
Bmper |
BMP-binding endothelial regulator |
decreases expression |
ISO |
licochalcone B results in decreased expression of BMPER mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256
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G |
Bpgm |
bisphosphoglycerate mutase |
increases expression |
ISO |
licochalcone B results in increased expression of BPGM mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581
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|
G |
Brms1 |
BRMS1, transcriptional repressor and anoikis regulator |
increases expression |
ISO |
licochalcone B results in increased expression of BRMS1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:202,345,766...202,355,028
Ensembl chr 1:202,345,704...202,355,028
|
|
G |
Bst1 |
bone marrow stromal cell antigen 1 |
increases expression |
ISO |
licochalcone B results in increased expression of BST1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180
|
|
G |
Btbd8 |
BTB domain containing 8 |
decreases expression |
ISO |
licochalcone B results in decreased expression of BTBD8 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr14:2,265,187...2,338,426
Ensembl chr14:2,266,454...2,334,393
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|
G |
Btg2 |
BTG anti-proliferation factor 2 |
increases expression |
ISO |
licochalcone B results in increased expression of BTG2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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|
G |
Btla |
B and T lymphocyte associated |
increases expression |
ISO |
licochalcone B results in increased expression of BTLA mRNA |
CTD |
PMID:33647349 |
|
NCBI chr11:55,563,683...55,588,187
Ensembl chr11:55,564,899...55,587,181
|
|
G |
C16h13orf46 |
similar to human chromosome 13 open reading frame 46 |
decreases expression |
ISO |
licochalcone B results in decreased expression of C13ORF46 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr16:75,974,501...75,987,629
Ensembl chr16:75,975,463...75,987,628
|
|
G |
C1h10orf95 |
similar to human chromosome 10 open reading frame 95 |
decreases expression |
ISO |
licochalcone B results in decreased expression of C10ORF95 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:245,210,228...245,212,080
Ensembl chr 1:245,210,973...245,211,602
|
|
G |
C1h11orf86 |
similar to human chromosome 11 open reading frame 86 |
decreases expression |
ISO |
licochalcone B results in decreased expression of C11ORF86 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:201,784,009...201,785,916
Ensembl chr 1:201,784,009...201,785,916
|
|
G |
C1ql3 |
complement C1q like 3 |
increases expression |
ISO |
licochalcone B results in increased expression of C1QL3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:76,119,344...76,129,170
Ensembl chr17:76,119,447...76,128,530
|
|
G |
C1qtnf4 |
C1q and TNF related 4 |
increases expression |
ISO |
licochalcone B results in increased expression of C1QTNF4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:76,854,368...76,872,991
Ensembl chr 3:76,857,735...76,874,139
|
|
G |
C5ar2 |
complement C5a receptor 2 |
decreases expression |
ISO |
licochalcone B results in decreased expression of C5AR2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:76,930,381...76,945,432
Ensembl chr 1:76,930,383...76,959,517
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|
G |
Cabp7 |
calcium binding protein 7 |
increases expression |
ISO |
licochalcone B results in increased expression of CABP7 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr14:79,598,822...79,609,172
Ensembl chr14:79,598,827...79,609,240
|
|
G |
Cacna2d2 |
calcium voltage-gated channel auxiliary subunit alpha2delta 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CACNA2D2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173
|
|
G |
Cacnb2 |
calcium voltage-gated channel auxiliary subunit beta 2 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CACNB2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
|
|
G |
Calb2 |
calbindin 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CALB2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438
|
|
G |
Card9 |
caspase recruitment domain family, member 9 |
increases expression |
ISO |
licochalcone B results in increased expression of CARD9 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237
|
|
G |
Carf |
calcium responsive transcription factor |
decreases expression |
ISO |
licochalcone B results in decreased expression of CARF mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:61,502,368...61,552,433
Ensembl chr 9:61,506,956...61,550,462
|
|
G |
Casp14 |
caspase 14 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CASP14 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
|
|
G |
Casp3 |
caspase 3 |
increases activity |
ISO |
licochalcone B results in increased activity of CASP3 protein |
CTD |
PMID:24384411 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp8 |
caspase 8 |
multiple interactions increases cleavage |
ISO |
TNFRSF10B protein promotes the reaction [licochalcone B results in increased cleavage of CASP8 protein] |
CTD |
PMID:35948134 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
|
|
G |
Cass4 |
Cas scaffold protein family member 4 |
increases expression |
ISO |
licochalcone B results in increased expression of CASS4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:161,162,520...161,202,523
Ensembl chr 3:161,163,436...161,202,186
|
|
G |
Catsperg |
cation channel sperm associated auxiliary subunit gamma |
increases expression |
ISO |
licochalcone B results in increased expression of CATSPERG mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:84,488,728...84,519,495
Ensembl chr 1:84,488,730...84,519,559
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|
G |
Cbarp |
CACN subunit beta associated regulatory protein |
increases expression |
ISO |
licochalcone B results in increased expression of CBARP mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:9,566,637...9,575,204
Ensembl chr 7:9,566,364...9,575,204
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|
G |
Cbx4 |
chromobox 4 |
increases expression |
ISO |
licochalcone B results in increased expression of CBX4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706
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|
G |
Ccdc13 |
coiled-coil domain containing 13 |
increases expression |
ISO |
licochalcone B results in increased expression of CCDC13 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:121,455,202...121,507,487
Ensembl chr 8:121,457,697...121,502,337
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|
G |
Ccdc148 |
coiled-coil domain containing 148 |
increases expression |
ISO |
licochalcone B results in increased expression of CCDC148 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:43,356,885...43,631,999
Ensembl chr 3:43,356,892...43,631,991
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|
G |
Ccdc194 |
coiled-coil domain containing 194 |
increases expression |
ISO |
licochalcone B results in increased expression of CCDC194 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr16:18,205,099...18,209,310
Ensembl chr16:18,205,095...18,209,283
|
|
G |
Ccdc68 |
coiled-coil domain containing 68 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CCDC68 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr18:63,541,828...63,584,122
Ensembl chr18:63,541,896...63,584,119
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|
G |
Ccdc9 |
coiled-coil domain containing 9 |
increases expression |
ISO |
licochalcone B results in increased expression of CCDC9 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:76,978,312...76,991,673
Ensembl chr 1:76,974,091...76,991,607
|
|
G |
Ccdc96 |
coiled-coil domain containing 96 |
increases expression |
ISO |
licochalcone B results in increased expression of CFAP184 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr14:74,276,568...74,279,072
Ensembl chr14:74,276,960...74,278,888
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|
G |
Ccm2l |
CCM2 like scaffold protein |
increases expression |
ISO |
licochalcone B results in increased expression of CCM2L mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:141,533,470...141,549,136
Ensembl chr 3:141,533,511...141,549,140
|
|
G |
Ccn1 |
cellular communication network factor 1 |
increases expression |
ISO |
licochalcone B results in increased expression of CCN1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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|
G |
Ccn2 |
cellular communication network factor 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CCN2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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|
G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CCNA2 mRNA |
CTD |
PMID:24384411 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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|
G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CCNB1 protein |
CTD |
PMID:35948134 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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|
G |
Ccne1 |
cyclin E1 |
increases expression |
ISO |
licochalcone B results in increased expression of CCNE1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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|
G |
Cd14 |
CD14 molecule |
increases expression |
ISO |
licochalcone B results in increased expression of CD14 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
|
|
G |
Cd247 |
Cd247 molecule |
increases expression |
ISO |
licochalcone B results in increased expression of CD247 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263
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|
G |
Cd27 |
CD27 molecule |
increases expression |
ISO |
licochalcone B results in increased expression of CD27 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592
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|
G |
Cd4 |
Cd4 molecule |
increases expression |
ISO |
licochalcone B results in increased expression of CD4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 4:157,668,878...157,695,366
|
|
G |
Cd79a |
CD79a molecule |
increases expression |
ISO |
licochalcone B results in increased expression of CD79A mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:80,493,581...80,497,936
Ensembl chr 1:80,493,581...80,497,935
|
|
G |
Cdc25a |
cell division cycle 25A |
decreases expression |
ISO |
licochalcone B results in decreased expression of CDC25A protein |
CTD |
PMID:24384411 |
|
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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|
G |
Cdc25b |
cell division cycle 25B |
decreases expression |
ISO |
licochalcone B results in decreased expression of CDC25B protein |
CTD |
PMID:24384411 |
|
NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
|
|
G |
Cdc34 |
cell division cycle 34, ubiqiutin conjugating enzyme |
increases expression |
ISO |
licochalcone B results in increased expression of CDC34 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:10,017,588...10,023,586
Ensembl chr 7:10,017,588...10,023,186
|
|
G |
Cdc42ep2 |
CDC42 effector protein 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CDC42EP2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:203,202,000...203,210,891
Ensembl chr 1:203,201,873...203,210,897
|
|
G |
Cdh23 |
cadherin-related 23 |
increases expression |
ISO |
licochalcone B results in increased expression of CDH23 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr20:28,240,643...28,622,490
Ensembl chr20:28,240,645...28,622,419
|
|
G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression multiple interactions |
ISO |
licochalcone B results in decreased expression of CDK1 mRNA licochalcone B results in decreased expression of and results in decreased phosphorylation of CDK1 protein |
CTD |
PMID:24384411 PMID:35948134 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
|
|
G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CDK2 mRNA |
CTD |
PMID:24384411 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
|
|
G |
Cdk2ap2 |
cyclin-dependent kinase 2 associated protein 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CDK2AP2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:201,391,056...201,393,137
Ensembl chr 1:201,391,466...201,393,137
|
|
G |
Cdk5r1 |
cyclin-dependent kinase 5 regulatory subunit 1 |
increases expression |
ISO |
licochalcone B results in increased expression of CDK5R1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
|
|
G |
Cdk5r2 |
cyclin-dependent kinase 5 regulatory subunit 2 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CDK5R2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:76,416,251...76,417,719
Ensembl chr 9:76,416,062...76,418,344
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
licochalcone B results in increased expression of CDKN1A mRNA |
CTD |
PMID:33647349 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
licochalcone B results in increased expression of CDKN1B protein |
CTD |
PMID:35948134 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
|
|
G |
Cdkn1c |
cyclin-dependent kinase inhibitor 1C |
increases expression |
ISO |
licochalcone B results in increased expression of CDKN1C mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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|
G |
Cdkn2d |
cyclin dependent kinase inhibitor 2D |
increases expression |
ISO |
licochalcone B results in increased expression of CDKN2D mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
|
|
G |
Celf5 |
CUGBP, Elav-like family member 5 |
increases expression |
ISO |
licochalcone B results in increased expression of CELF5 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:8,225,787...8,250,322
Ensembl chr 7:8,225,825...8,250,322
|
|
G |
Cenpe |
centromere protein E |
decreases expression |
ISO |
licochalcone B results in decreased expression of CENPE mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
|
|
G |
Cfap141 |
cilia and flagella associated protein 141 |
increases expression |
ISO |
licochalcone B results in increased expression of CFAP141 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:175,507,628...175,510,662
Ensembl chr 2:175,507,628...175,510,662
|
|
G |
Cfap20 |
cilia and flagella associated protein 20 |
increases expression |
ISO |
licochalcone B results in increased expression of CFAP20 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr19:9,608,867...9,622,558
Ensembl chr19:9,608,859...9,622,558
|
|
G |
Cfap43 |
cilia and flagella associated protein 43 |
increases expression |
ISO |
licochalcone B results in increased expression of CFAP43 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:246,625,259...246,712,438
Ensembl chr 1:246,625,262...246,712,443
|
|
G |
Cfap99 |
cilia and flagella associated protein 99 |
increases expression |
ISO |
licochalcone B results in increased expression of CFAP99 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr14:76,423,923...76,468,170
Ensembl chr14:76,410,555...76,468,125
|
|
G |
Cfp |
complement factor properdin |
increases expression |
ISO |
licochalcone B results in increased expression of CFP mRNA |
CTD |
PMID:33647349 |
|
NCBI chr X:1,162,014...1,167,576
Ensembl chr X:1,161,979...1,167,573
|
|
G |
Chac1 |
ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
increases expression |
ISO |
licochalcone B results in increased expression of CHAC1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
|
|
G |
Chchd7 |
coiled-coil-helix-coiled-coil-helix domain containing 7 |
increases expression |
ISO |
licochalcone B results in increased expression of CHCHD7 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 5:16,957,127...16,961,682
Ensembl chr 5:16,957,188...16,961,184
|
|
G |
Chek2 |
checkpoint kinase 2 |
increases phosphorylation |
ISO |
licochalcone B results in increased phosphorylation of CHEK2 protein |
CTD |
PMID:35948134 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
|
|
G |
Chrm3 |
cholinergic receptor, muscarinic 3 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CHRM3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
|
|
G |
Chrm4 |
cholinergic receptor, muscarinic 4 |
increases expression |
ISO |
licochalcone B results in increased expression of CHRM4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
|
|
G |
Chrna3 |
cholinergic receptor nicotinic alpha 3 subunit |
increases expression |
ISO |
licochalcone B results in increased expression of CHRNA3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
|
|
G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
increases expression |
ISO |
licochalcone B results in increased expression of CHRNA7 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
|
|
G |
Chrnd |
cholinergic receptor nicotinic delta subunit |
decreases expression |
ISO |
licochalcone B results in decreased expression of CHRND mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:87,862,417...87,870,833
Ensembl chr 9:87,862,407...87,870,833
|
|
G |
Chrng |
cholinergic receptor nicotinic gamma subunit |
decreases expression |
ISO |
licochalcone B results in decreased expression of CHRNG mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:87,878,085...87,884,193
Ensembl chr 9:87,878,085...87,914,482
|
|
G |
Cimip2a |
ciliary microtubule inner protein 2A |
increases expression |
ISO |
licochalcone B results in increased expression of CIMIP2A mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:8,030,548...8,038,370
Ensembl chr 3:8,033,246...8,037,961
|
|
G |
Cited2 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CITED2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
|
|
G |
Cks2 |
CDC28 protein kinase regulatory subunit 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CKS2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:13,570,611...13,575,770
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G |
Cldn19 |
claudin 19 |
increases expression |
ISO |
licochalcone B results in increased expression of CLDN19 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 5:132,862,939...132,870,364
Ensembl chr 5:132,863,267...132,868,227
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G |
Cldn6 |
claudin 6 |
increases expression |
ISO |
licochalcone B results in increased expression of CLDN6 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:12,710,302...12,713,987
Ensembl chr10:12,709,960...12,715,973
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G |
Cldn9 |
claudin 9 |
increases expression |
ISO |
licochalcone B results in increased expression of CLDN9 mRNA |
CTD |
PMID:33647349 |
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NCBI chr10:12,714,137...12,715,568
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G |
Clu |
clusterin |
increases expression |
ISO |
licochalcone B results in increased expression of CLU mRNA |
CTD |
PMID:33647349 |
|
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Cnih3 |
cornichon family AMPA receptor auxiliary protein 3 |
increases expression |
ISO |
licochalcone B results in increased expression of CNIH3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr13:93,016,707...93,208,168
Ensembl chr13:93,099,784...93,208,121
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G |
Cnnm4 |
cyclin and CBS domain divalent metal cation transport mediator 4 |
increases expression |
ISO |
licochalcone B results in increased expression of CNNM4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:38,711,726...38,750,942
Ensembl chr 9:38,711,710...38,750,942
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G |
Cntn2 |
contactin 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CNTN2 mRNA |
CTD |
PMID:33647349 |
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NCBI chr13:43,942,868...43,975,973
Ensembl chr13:43,947,265...43,975,887
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G |
Col6a2 |
collagen type VI alpha 2 chain |
increases expression |
ISO |
licochalcone B results in increased expression of COL6A2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564
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G |
Cox8c |
cytochrome c oxidase subunit 8C |
increases expression |
ISO |
licochalcone B results in increased expression of COX8C mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 6:122,028,566...122,029,889
Ensembl chr 6:122,028,566...122,029,889
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G |
Cplx2 |
complexin 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CPLX2 mRNA |
CTD |
PMID:33647349 |
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NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855
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G |
Cps1 |
carbamoyl-phosphate synthase 1 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CPS1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
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|
G |
Crispld1 |
cysteine-rich secretory protein LCCL domain containing 1 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CRISPLD1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 5:1,267,347...1,314,926
Ensembl chr 5:1,274,647...1,314,926
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|
G |
Crispld2 |
cysteine-rich secretory protein LCCL domain containing 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CRISPLD2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465
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G |
Cryba1 |
crystallin, beta A1 |
increases expression |
ISO |
licochalcone B results in increased expression of CRYBA1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:62,608,373...62,614,726
Ensembl chr10:62,608,383...62,614,726
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G |
Crybg1 |
crystallin beta-gamma domain containing 1 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CRYBG1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr20:47,425,030...47,496,918
Ensembl chr20:47,426,183...47,621,392
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G |
Crym |
crystallin, mu |
increases expression |
ISO |
licochalcone B results in increased expression of CRYM mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
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|
G |
Csrnp1 |
cysteine and serine rich nuclear protein 1 |
increases expression |
ISO |
licochalcone B results in increased expression of CSRNP1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
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|
G |
Csrnp2 |
cysteine and serine rich nuclear protein 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CSRNP2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:131,594,232...131,610,075
Ensembl chr 7:131,594,232...131,610,075
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|
G |
Csrp2 |
cysteine and glycine-rich protein 2 |
increases expression |
ISO |
licochalcone B results in increased expression of CSRP2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
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|
G |
Ctrc |
chymotrypsin C |
increases expression |
ISO |
licochalcone B results in increased expression of CTRC mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 5:154,147,314...154,156,540
Ensembl chr 5:154,147,316...154,156,528
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|
G |
Cxxc4 |
CXXC finger protein 4 |
decreases expression |
ISO |
licochalcone B results in decreased expression of CXXC4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:222,664,148...222,689,365
Ensembl chr 2:222,664,771...222,689,365
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|
G |
Cygb |
cytoglobin |
decreases expression |
ISO |
licochalcone B results in decreased expression of CYGB mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442
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|
G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
increases expression |
ISO |
licochalcone B results in increased expression of CYP27A1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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|
G |
Dact3 |
dishevelled-binding antagonist of beta-catenin 3 |
increases expression |
ISO |
licochalcone B results in increased expression of DACT3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:77,546,900...77,558,631
Ensembl chr 1:77,546,900...77,558,630
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|
G |
Dcxr |
dicarbonyl and L-xylulose reductase |
increases expression |
ISO |
licochalcone B results in increased expression of DCXR mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:106,006,404...106,008,293
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
licochalcone B results in increased expression of DDIT3 mRNA; licochalcone B results in increased expression of DDIT3 protein |
CTD |
PMID:33647349 PMID:35948134 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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|
G |
Ddr2 |
discoidin domain receptor tyrosine kinase 2 |
increases expression |
ISO |
licochalcone B results in increased expression of DDR2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
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|
G |
Ddx60 |
DEXD/H-box helicase 60 |
decreases expression |
ISO |
licochalcone B results in decreased expression of DDX60 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526
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|
G |
Dedd2 |
death effector domain containing 2 |
increases expression |
ISO |
licochalcone B results in increased expression of DEDD2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:80,789,084...80,807,789
Ensembl chr 1:80,792,000...80,807,714
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|
G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
increases expression |
ISO |
licochalcone B results in increased expression of DGAT1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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|
G |
Dhdh |
dihydrodiol dehydrogenase |
increases expression |
ISO |
licochalcone B results in increased expression of DHDH mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:95,954,361...95,965,262
Ensembl chr 1:95,953,092...95,965,197
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|
G |
Dhx58 |
DEXH-box helicase 58 |
increases expression |
ISO |
licochalcone B results in increased expression of DHX58 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
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|
G |
Dio2 |
iodothyronine deiodinase 2 |
decreases expression |
ISO |
licochalcone B results in decreased expression of DIO2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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|
G |
Dio3 |
iodothyronine deiodinase 3 |
increases expression |
ISO |
licochalcone B results in increased expression of DIO3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
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|
G |
Disp3 |
dispatched RND transporter family member 3 |
increases expression |
ISO |
licochalcone B results in increased expression of DISP3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 5:158,672,015...158,720,806
Ensembl chr 5:158,672,015...158,720,806
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|
G |
Dixdc1 |
DIX domain containing 1 |
decreases expression |
ISO |
licochalcone B results in decreased expression of DIXDC1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090
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|
G |
Dlg3 |
discs large MAGUK scaffold protein 3 |
decreases expression |
ISO |
licochalcone B results in decreased expression of DLG3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr X:65,859,653...65,911,887
Ensembl chr X:65,860,172...65,910,322
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|
G |
Dll4 |
delta like canonical Notch ligand 4 |
increases expression |
ISO |
licochalcone B results in increased expression of DLL4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931
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|
G |
Dlx2 |
distal-less homeobox 2 |
increases expression |
ISO |
licochalcone B results in increased expression of DLX2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597
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|
G |
Dmbt1 |
deleted in malignant brain tumors 1 |
decreases expression |
ISO |
licochalcone B results in decreased expression of DMBT1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478
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|
G |
Dnah3 |
dynein, axonemal, heavy chain 3 |
increases expression |
ISO |
licochalcone B results in increased expression of DNAH3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:174,305,929...174,479,490
Ensembl chr 1:174,306,644...174,479,474
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|
G |
Dnaja4 |
DnaJ heat shock protein family (Hsp40) member A4 |
increases expression |
ISO |
licochalcone B results in increased expression of DNAJA4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207
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|
G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
increases expression |
ISO |
licochalcone B results in increased expression of DNAJB1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
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|
G |
Dnajc28 |
DnaJ heat shock protein family (Hsp40) member C28 |
decreases expression |
ISO |
licochalcone B results in decreased expression of DNAJC28 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr11:30,855,566...30,858,386
Ensembl chr11:30,853,526...30,858,441
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|
G |
Dock3 |
dedicator of cyto-kinesis 3 |
increases expression |
ISO |
licochalcone B results in increased expression of DOCK3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:107,552,462...107,903,527
Ensembl chr 8:107,552,463...107,903,514
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|
G |
Drap1 |
Dr1 associated protein 1 |
increases expression |
ISO |
licochalcone B results in increased expression of DRAP1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:202,731,775...202,734,468
Ensembl chr 1:202,731,788...202,734,425
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|
G |
Drc1 |
dynein regulatory complex subunit 1 |
increases expression |
ISO |
licochalcone B results in increased expression of DRC1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 6:26,025,004...26,059,438
Ensembl chr 6:26,025,005...26,059,414
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|
G |
Dtx3l |
deltex E3 ubiquitin ligase 3L |
decreases expression |
ISO |
licochalcone B results in decreased expression of DTX3L mRNA |
CTD |
PMID:33647349 |
|
NCBI chr11:64,814,926...64,824,539
Ensembl chr11:64,814,926...64,824,538
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|
G |
Dusp2 |
dual specificity phosphatase 2 |
increases expression |
ISO |
licochalcone B results in increased expression of DUSP2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499
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G |
Dusp5 |
dual specificity phosphatase 5 |
increases expression |
ISO |
licochalcone B results in increased expression of DUSP5 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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G |
Dusp7 |
dual specificity phosphatase 7 |
increases expression |
ISO |
licochalcone B results in increased expression of DUSP7 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:107,009,369...107,016,404
Ensembl chr 8:107,008,528...107,016,404
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|
G |
Eddm13 |
epididymal protein 13 |
decreases expression |
ISO |
licochalcone B results in decreased expression of EDDM13 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:67,630,905...67,656,404
Ensembl chr 1:67,626,244...67,657,342
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|
G |
Ednra |
endothelin receptor type A |
decreases expression |
ISO |
licochalcone B results in decreased expression of EDNRA mRNA |
CTD |
PMID:33647349 |
|
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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G |
Eeig1 |
estrogen-induced osteoclastogenesis regulator 1 |
increases expression |
ISO |
licochalcone B results in increased expression of EEIG1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:15,822,441...15,854,651
Ensembl chr 3:15,823,144...15,854,643
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G |
Efnb2 |
ephrin B2 |
increases expression |
ISO |
licochalcone B results in increased expression of EFNB2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391
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G |
Efnb3 |
ephrin B3 |
increases expression |
ISO |
licochalcone B results in increased expression of EFNB3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:54,274,506...54,281,951
Ensembl chr10:54,274,506...54,280,471
|
|
G |
Egfl8 |
EGF-like-domain, multiple 8 |
decreases expression |
ISO |
licochalcone B results in decreased expression of EGFL8 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr20:4,132,930...4,136,024
Ensembl chr20:4,133,629...4,136,018
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|
G |
Egr1 |
early growth response 1 |
increases expression |
ISO |
licochalcone B results in increased expression of EGR1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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|
G |
Egr3 |
early growth response 3 |
increases expression |
ISO |
licochalcone B results in increased expression of EGR3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
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|
G |
Ehd1 |
EH-domain containing 1 |
increases expression |
ISO |
licochalcone B results in increased expression of EHD1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212
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|
G |
Ehf |
ets homologous factor |
decreases expression |
ISO |
licochalcone B results in decreased expression of EHF mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 3:89,639,845...89,680,061
Ensembl chr 3:89,641,833...89,679,997
|
|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
decreases expression |
ISO |
licochalcone B results in decreased expression of EIF2AK3 protein |
CTD |
PMID:35948134 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
|
|
G |
Eif4a1 |
eukaryotic translation initiation factor 4A1 |
increases expression |
ISO |
licochalcone B results in increased expression of EIF4A1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858
|
|
G |
Eif4a3 |
eukaryotic translation initiation factor 4A3 |
increases expression |
ISO |
licochalcone B results in increased expression of EIF4A3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057
|
|
G |
Emc9 |
ER membrane protein complex subunit 9 |
increases expression |
ISO |
licochalcone B results in increased expression of EMC9 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr15:29,071,881...29,076,098
Ensembl chr15:29,071,883...29,076,098
|
|
G |
Engase |
endo-beta-N-acetylglucosaminidase |
increases expression |
ISO |
licochalcone B results in increased expression of ENGASE mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:103,707,169...103,719,833
Ensembl chr10:103,707,169...103,719,819
|
|
G |
Epha2 |
Eph receptor A2 |
increases expression |
ISO |
licochalcone B results in increased expression of EPHA2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117
|
|
G |
Epha3 |
Eph receptor A3 |
decreases expression |
ISO |
licochalcone B results in decreased expression of EPHA3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900
|
|
G |
Eppk1 |
epiplakin 1 |
increases expression |
ISO |
licochalcone B results in increased expression of EPPK1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:107,816,919...107,842,946
Ensembl chr 7:107,817,693...107,831,159
|
|
G |
Eras |
ES cell expressed Ras |
increases expression |
ISO |
licochalcone B results in increased expression of ERAS mRNA |
CTD |
PMID:33647349 |
|
NCBI chr X:14,573,987...14,578,455
Ensembl chr X:14,573,987...14,578,374
|
|
G |
Erf |
Ets2 repressor factor |
increases expression |
ISO |
licochalcone B results in increased expression of ERF mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:80,829,935...80,838,388
Ensembl chr 1:80,829,935...80,838,388
|
|
G |
Erlin2 |
ER lipid raft associated 2 |
decreases expression |
ISO |
licochalcone B results in decreased expression of ERLIN2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671
|
|
G |
Espn |
espin |
increases expression |
ISO |
licochalcone B results in increased expression of ESPN mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 5:162,626,560...162,660,439
Ensembl chr 5:162,626,560...162,660,256
|
|
G |
Eva1b |
eva-1 homolog B |
increases expression |
ISO |
licochalcone B results in increased expression of EVA1B mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 5:138,427,088...138,429,602
Ensembl chr 5:138,427,151...138,432,433
|
|
G |
Exoc3l2 |
exocyst complex component 3-like 2 |
increases expression |
ISO |
licochalcone B results in increased expression of EXOC3L2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:79,113,784...79,145,359
Ensembl chr 1:79,112,506...79,145,465
|
|
G |
F2r |
coagulation factor II (thrombin) receptor |
decreases expression |
ISO |
licochalcone B results in decreased expression of F2R mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
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G |
Fam117a |
family with sequence similarity 117, member A |
increases expression |
ISO |
licochalcone B results in increased expression of FAM117A mRNA |
CTD |
PMID:33647349 |
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NCBI chr10:80,281,411...80,325,345
Ensembl chr10:80,281,408...80,325,343
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G |
Fam222a |
family with sequence similarity 222, member A |
increases expression |
ISO |
licochalcone B results in increased expression of FAM222A mRNA |
CTD |
PMID:33647349 |
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NCBI chr12:41,982,064...42,033,085
Ensembl chr12:41,986,780...42,033,682
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G |
Fam228b |
family with sequence similarity 228, member B |
increases expression |
ISO |
licochalcone B results in increased expression of FAM228B mRNA |
CTD |
PMID:33647349 |
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NCBI chr 6:27,754,505...27,786,578
Ensembl chr 6:27,754,506...27,786,537
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G |
Fam43a |
family with sequence similarity 43, member A |
increases expression |
ISO |
licochalcone B results in increased expression of FAM43A mRNA |
CTD |
PMID:33647349 |
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NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401
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G |
Fam78a |
family with sequence similarity 78, member A |
decreases expression |
ISO |
licochalcone B results in decreased expression of FAM78A mRNA |
CTD |
PMID:33647349 |
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NCBI chr 3:15,355,958...15,376,330
Ensembl chr 3:15,355,955...15,373,812
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G |
Fam89b |
family with sequence similarity 89, member B |
increases expression |
ISO |
licochalcone B results in increased expression of FAM89B mRNA |
CTD |
PMID:33647349 |
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NCBI chr 1:203,015,772...203,017,890
Ensembl chr 1:203,015,773...203,017,367
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G |
Fam90a1a |
family with sequence similarity 90 member A1A |
increases expression |
ISO |
licochalcone B results in increased expression of FAM90A1 mRNA |
CTD |
PMID:33647349 |
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NCBI chr16:70,098,439...70,106,147
Ensembl chr16:70,098,740...70,101,241
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G |
Fbll1 |
fibrillarin-like 1 |
increases expression |
ISO |
licochalcone B results in increased expression of FBLL1 mRNA |
CTD |
PMID:33647349 |
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NCBI chr10:20,258,656...20,260,299
Ensembl chr10:20,258,656...20,260,299
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G |
Fbxo32 |
F-box protein 32 |
increases expression |
ISO |
licochalcone B results in increased expression of FBXO32 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
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G |
Fcgbp |
Fc gamma binding protein |
increases expression |
ISO |
licochalcone B results in increased expression of FCGBP mRNA |
CTD |
PMID:33647349 |
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NCBI chr 1:83,374,979...83,413,082
Ensembl chr 1:83,372,127...83,413,083
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G |
Fcgr1a |
Fc gamma receptor 1A |
increases expression |
ISO |
licochalcone B results in increased expression of FCGR1A mRNA |
CTD |
PMID:33647349 |
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NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994
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G |
Fer1l5 |
fer-1-like family member 5 |
increases expression |
ISO |
licochalcone B results in increased expression of FER1L5 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 9:38,605,835...38,661,869
Ensembl chr 9:38,607,843...38,660,425
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G |
Fgf18 |
fibroblast growth factor 18 |
increases expression |
ISO |
licochalcone B results in increased expression of FGF18 mRNA |
CTD |
PMID:33647349 |
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NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
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G |
Fgf22 |
fibroblast growth factor 22 |
increases expression |
ISO |
licochalcone B results in increased expression of FGF22 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 7:9,947,632...9,956,918
Ensembl chr 7:9,948,071...9,950,486
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G |
Fgfr3 |
fibroblast growth factor receptor 3 |
increases expression |
ISO |
licochalcone B results in increased expression of FGFR3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
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G |
Fitm1 |
fat storage-inducing transmembrane protein 1 |
increases expression |
ISO |
licochalcone B results in increased expression of FITM1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr15:29,064,746...29,066,015
Ensembl chr15:29,064,707...29,066,015
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
ISO |
licochalcone B results in increased expression of FOS mRNA licochalcone B analog inhibits the reaction [Lipopolysaccharides affects the localization of FOS protein] |
CTD |
PMID:25451593 PMID:33647349 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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|
G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
licochalcone B results in increased expression of FOSB mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
licochalcone B results in increased expression of FOSL1 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Foxa3 |
forkhead box A3 |
increases expression |
ISO |
licochalcone B results in increased expression of FOXA3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155
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G |
Foxd1 |
forkhead box D1 |
increases expression |
ISO |
licochalcone B results in increased expression of FOXD1 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 2:29,702,558...29,704,978
Ensembl chr 2:29,702,558...29,704,978
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G |
Foxe3 |
forkhead box E3 |
increases expression |
ISO |
licochalcone B results in increased expression of FOXE3 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 5:128,444,912...128,446,494
Ensembl chr 5:128,445,594...128,446,454
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G |
Foxp4 |
forkhead box P4 |
increases expression |
ISO |
licochalcone B results in increased expression of FOXP4 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 9:13,058,506...13,115,406
Ensembl chr 9:13,058,476...13,114,879
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G |
Frey1 |
Frey regulator of sperm-oocyte fusion 1 |
increases expression |
ISO |
licochalcone B results in increased expression of FREY1 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 3:78,354,303...78,355,055
Ensembl chr 3:78,354,303...78,355,055
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G |
Frg2 |
FSHD region gene 2 |
increases expression |
ISO |
licochalcone B results in increased expression of FRG2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr14:80,427,260...80,429,560
Ensembl chr14:80,427,673...80,429,181
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G |
Fry |
FRY microtubule binding protein |
decreases expression |
ISO |
licochalcone B results in decreased expression of FRY mRNA |
CTD |
PMID:33647349 |
|
NCBI chr12:4,493,890...4,887,118
Ensembl chr12:4,493,891...4,799,116
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|
G |
Frzb |
frizzled-related protein |
increases expression |
ISO |
licochalcone B results in increased expression of FRZB mRNA |
CTD |
PMID:33647349 |
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NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208
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|
G |
Fut1 |
fucosyltransferase 1 |
decreases expression |
ISO |
licochalcone B results in decreased expression of FUT1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:96,086,934...96,090,352
Ensembl chr 1:96,086,635...96,090,616
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|
G |
Fyco1 |
FYVE and coiled-coil domain autophagy adaptor 1 |
decreases expression |
ISO |
licochalcone B results in decreased expression of FYCO1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:123,412,105...123,479,315
Ensembl chr 8:123,412,112...123,479,021
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|
G |
Fzd7 |
frizzled class receptor 7 |
increases expression |
ISO |
licochalcone B results in increased expression of FZD7 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
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|
G |
Gabrr2 |
gamma-aminobutyric acid type A receptor subunit rho 2 |
increases expression |
ISO |
licochalcone B results in increased expression of GABRR2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 5:47,445,280...47,489,929
Ensembl chr 5:47,452,150...47,489,809
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|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
licochalcone B results in increased expression of GADD45A mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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|
G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
increases expression |
ISO |
licochalcone B results in increased expression of GADD45B mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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|
G |
Galntl6 |
polypeptide N-acetylgalactosaminyltransferase-like 6 |
decreases expression |
ISO |
licochalcone B results in decreased expression of GALNTL6 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr16:31,192,880...32,443,979
Ensembl chr16:31,186,462...32,441,960
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|
G |
Galr2 |
galanin receptor 2 |
increases expression |
ISO |
licochalcone B results in increased expression of GALR2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176
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G |
Gata2 |
GATA binding protein 2 |
increases expression |
ISO |
licochalcone B results in increased expression of GATA2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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G |
Gata3 |
GATA binding protein 3 |
increases expression |
ISO |
licochalcone B results in increased expression of GATA3 mRNA |
CTD |
PMID:33647349 |
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NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
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G |
Gbx2 |
gastrulation brain homeobox 2 |
increases expression |
ISO |
licochalcone B results in increased expression of GBX2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:90,509,633...90,512,212
Ensembl chr 9:90,509,633...90,512,212
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G |
Gcm1 |
glial cells missing transcription factor 1 |
increases expression |
ISO |
licochalcone B results in increased expression of GCM1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 8:78,925,687...78,938,924
Ensembl chr 8:78,925,687...78,938,924
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G |
Gem |
GTP binding protein overexpressed in skeletal muscle |
increases expression |
ISO |
licochalcone B results in increased expression of GEM mRNA |
CTD |
PMID:33647349 |
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NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
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G |
Get4 |
guided entry of tail-anchored proteins factor 4 |
increases expression |
ISO |
licochalcone B results in increased expression of GET4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr12:15,377,009...15,394,238
Ensembl chr12:15,377,009...15,394,053
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G |
Gfi1 |
growth factor independent 1 transcriptional repressor |
decreases expression |
ISO |
licochalcone B results in decreased expression of GFI1 mRNA |
CTD |
PMID:33647349 |
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NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814
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|
G |
Gfpt2 |
glutamine-fructose-6-phosphate transaminase 2 |
increases expression |
ISO |
licochalcone B results in increased expression of GFPT2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329
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G |
Gfra3 |
GDNF family receptor alpha 3 |
increases expression |
ISO |
licochalcone B results in increased expression of GFRA3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr18:26,297,828...26,326,105
Ensembl chr18:26,297,829...26,326,105
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|
G |
Gipc2 |
GIPC PDZ domain containing family, member 2 |
increases expression |
ISO |
licochalcone B results in increased expression of GIPC2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:241,030,764...241,110,236
Ensembl chr 2:241,030,770...241,110,236
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G |
Gng13 |
G protein subunit gamma 13 |
increases expression |
ISO |
licochalcone B results in increased expression of GNG13 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:14,741,179...14,743,083
Ensembl chr10:14,741,239...14,743,083
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|
G |
Gstm5l |
glutathione S-transferase, mu 5-like |
increases expression |
ISO |
licochalcone B results in increased expression of GSTM5 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961
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G |
Gzmm |
granzyme M |
increases expression |
ISO |
licochalcone B results in increased expression of GZMM mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 7:10,011,065...10,016,841
Ensembl chr 7:10,011,066...10,016,665
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G |
H1f4 |
H1.4 linker histone, cluster member |
increases expression |
ISO |
licochalcone B results in increased expression of H1-4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403
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G |
H2ac12 |
H2A clustered histone 12 |
increases expression |
ISO |
licochalcone B results in increased expression of H2AC12 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:42,486,415...42,486,880
Ensembl chr17:42,486,415...42,486,941
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G |
H2ac21 |
H2A clustered histone 21 |
increases expression |
ISO |
licochalcone B results in increased expression of H2AC21 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:183,779,355...183,779,788
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|
G |
H2ax |
H2A.X variant histone |
increases expression increases phosphorylation |
ISO |
licochalcone B results in increased expression of H2AX mRNA licochalcone B results in increased phosphorylation of H2AX protein |
CTD |
PMID:33647349 PMID:35948134 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
H2bc12 |
H2B clustered histone 12 |
increases expression |
ISO |
licochalcone B results in increased expression of H2BC12 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:42,485,699...42,486,162
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|
G |
H2bc18 |
H2B clustered histone 18 |
increases expression |
ISO |
licochalcone B results in increased expression of H2BC18 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:183,838,331...183,842,769
Ensembl chr 2:183,838,334...183,841,529
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G |
H2bc6 |
H2B clustered histone 6 |
increases expression |
ISO |
licochalcone B results in increased expression of H2BC6 mRNA |
CTD |
PMID:33647349 |
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NCBI chr17:41,520,775...41,521,238
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|
G |
H2bc8 |
H2B clustered histone 8 |
increases expression |
ISO |
licochalcone B results in increased expression of H2BC8 mRNA |
CTD |
PMID:33647349 |
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NCBI chr17:42,708,658...42,709,408
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|
G |
H2bc9 |
H2B clustered histone 9 |
increases expression |
ISO |
licochalcone B results in increased expression of H2BC9 mRNA |
CTD |
PMID:33647349 |
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NCBI chr17:42,470,593...42,478,590
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G |
H3c1 |
H3 clustered histone 1 |
increases expression |
ISO |
licochalcone B results in increased expression of H3C1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856
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|
G |
H3c13 |
H3 clustered histone 13 |
increases expression |
ISO |
licochalcone B results in increased expression of H3C13 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:41,531,502...41,531,971
Ensembl chr 2:183,795,504...183,809,469 Ensembl chr17:183,795,504...183,809,469 Ensembl chr 2:183,795,504...183,809,469 Ensembl chr17:183,795,504...183,809,469 Ensembl chr17:183,795,504...183,809,469 Ensembl chr 2:183,795,504...183,809,469
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G |
Hamp |
hepcidin antimicrobial peptide |
increases expression |
ISO |
licochalcone B results in increased expression of HAMP mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Hapln2 |
hyaluronan and proteoglycan link protein 2 |
increases expression |
ISO |
licochalcone B results in increased expression of HAPLN2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 2:173,488,909...173,496,824
Ensembl chr 2:173,491,160...173,496,588
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|
G |
Hapln3 |
hyaluronan and proteoglycan link protein 3 |
increases expression |
ISO |
licochalcone B results in increased expression of HAPLN3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:133,046,465...133,064,665
Ensembl chr 1:133,046,467...133,080,177
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G |
Has1 |
hyaluronan synthase 1 |
increases expression |
ISO |
licochalcone B results in increased expression of HAS1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397
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G |
Has3 |
hyaluronan synthase 3 |
increases expression |
ISO |
licochalcone B results in increased expression of HAS3 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr19:34,768,421...34,782,170
Ensembl chr19:34,771,982...34,782,592
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G |
Hba-a2 |
hemoglobin alpha, adult chain 2 |
increases expression |
ISO |
licochalcone B results in increased expression of HBA1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
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G |
Hbegf |
heparin-binding EGF-like growth factor |
increases expression |
ISO |
licochalcone B results in increased expression of HBEGF mRNA |
CTD |
PMID:33647349 |
|
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
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G |
Herpud1 |
homocysteine inducible ER protein with ubiquitin like domain 1 |
increases expression |
ISO |
licochalcone B results in increased expression of HERPUD1 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
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G |
Hes6 |
hes family bHLH transcription factor 6 |
increases expression |
ISO |
licochalcone B results in increased expression of HES6 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559
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G |
Hes7 |
hes family bHLH transcription factor 7 |
increases expression |
ISO |
licochalcone B results in increased expression of HES7 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr10:53,824,124...53,828,934
Ensembl chr10:53,825,574...53,828,097
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G |
Hic2 |
HIC ZBTB transcriptional repressor 2 |
increases expression |
ISO |
licochalcone B results in increased expression of HIC2 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr11:83,737,075...83,789,554
Ensembl chr11:83,738,874...83,767,484
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G |
Hipk4 |
homeodomain interacting protein kinase 4 |
increases expression |
ISO |
licochalcone B results in increased expression of HIPK4 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr 1:82,810,708...82,821,080
Ensembl chr 1:82,810,708...82,821,077
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G |
Hist1h2af |
histone cluster 1 H2A family member F |
increases expression |
ISO |
licochalcone B results in increased expression of H2AC8 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:41,379,404...41,379,796
Ensembl chr17:41,379,404...41,379,796
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G |
Hist1h2bd |
histone cluster 1 H2B family member D |
increases expression |
ISO |
licochalcone B results in increased expression of H2BC5 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:42,792,887...42,793,268
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|
G |
Hist1h2bq |
histone cluster 1 H2B family member Q |
increases expression |
ISO |
licochalcone B results in increased expression of H2BC7 mRNA |
CTD |
PMID:33647349 |
|
NCBI chr17:41,432,100...41,441,487
Ensembl chr17:41,429,164...41,442,153
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G |
Hist1h4b |
histone cluster 1 H4 family member B |
increases expression |
ISO |
licochalcone B results in increased expression of H4C9 mRNA |
CTD |
PMID:33647349 |
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NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
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Hist1h4m |
histone cluster 1, H4m |
increases expression |
ISO |
licochalcone B results in increased expression of H4C1 mRNA |
CTD |
PMID:33647349 |
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NCBI chr17:42,698,016...42,698,420
Ensembl chr17:42,698,025...42,698,958
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Hist2h2be |
histone cluster 2 H2B family member E |
increases expression |
ISO |
licochalcone B results in increased expression of H2BC11 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 2:183,780,583...183,783,030
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Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
licochalcone B results in increased expression of HMOX1 mRNA |
CTD |
PMID:33647349 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Homer2 |
homer scaffold protein 2 |
increases expression |
ISO |
licochalcone B results in increased expression of HOMER2 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 1:135,558,977...135,659,780
Ensembl chr 1:135,567,414...135,659,772
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Hoxc4 |
homeo box C4 |
decreases expression |
ISO |
licochalcone B results in decreased expression of HOXC4 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 7:134,135,279...134,173,133
Ensembl chr 7:134,170,591...134,173,133
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Hpx |
hemopexin |
increases expression |
ISO |
licochalcone B results in increased expression of HPX mRNA |
CTD |
PMID:33647349 |
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NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328
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Hspa1a |
heat shock protein family A (Hsp70) member 1A |
increases expression |
ISO |
licochalcone B results in increased expression of HSPA1A mRNA |
CTD |
PMID:33647349 |
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NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression |
ISO |
licochalcone B results in increased expression of HSPA1B mRNA |
CTD |
PMID:33647349 |
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NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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Hspa1l |
heat shock protein family A (Hsp70) member 1 like |
increases expression |
ISO |
licochalcone B results in increased expression of HSPA1L mRNA |
CTD |
PMID:33647349 |
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NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
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Hspa6l-ps1 |
heat shock protein family A (Hsp70) member 6 like, pseudogene 1 |
increases expression |
ISO |
licochalcone B results in increased expression of HSPA6 mRNA |
CTD |
PMID:33647349 |
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NCBI chr13:83,273,176...83,274,317
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Hspa8 |
heat shock protein family A (Hsp70) member 8 |
increases expression |
ISO |
licochalcone B results in increased expression of HSPA8 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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Hspb8 |
heat shock protein family B (small) member 8 |
increases expression |
ISO |
licochalcone B results in increased expression of HSPB8 mRNA |
CTD |
PMID:33647349 |
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NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
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Hspb9 |
heat shock protein family B (small) member 9 |
increases expression |
ISO |
licochalcone B results in increased expression of HSPB9 mRNA |
CTD |
PMID:33647349 |
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NCBI chr10:85,641,284...85,641,929
Ensembl chr10:85,641,284...85,641,929
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Hsph1 |
heat shock protein family H (Hsp110) member 1 |
increases expression |
ISO |
licochalcone B results in increased expression of HSPH1 mRNA |
CTD |
PMID:33647349 |
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NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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Hus1b |
HUS1 checkpoint clamp component B |
increases expression |
ISO |
licochalcone B results in increased expression of HUS1B mRNA |
CTD |
PMID:33647349 |
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NCBI chr17:33,534,032...33,535,199
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Id2 |
inhibitor of DNA binding 2 |
increases expression |
ISO |
licochalcone B results in increased expression of ID2 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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Ier5 |
immediate early response 5 |
increases expression |
ISO |
licochalcone B results in increased expression of IER5 mRNA |
CTD |
PMID:33647349 |
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NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227
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Ier5l |
immediate early response 5-like |
increases expression |
ISO |
licochalcone B results in increased expression of IER5L mRNA |
CTD |
PMID:33647349 |
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NCBI chr 3:13,744,056...13,745,647
Ensembl chr 3:13,744,078...13,745,647
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Ifi30 |
IFI30, lysosomal thiol reductase |
increases expression |
ISO |
licochalcone B results in increased expression of IFI30 mRNA |
CTD |
PMID:33647349 |
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NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175
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Ifih1 |
interferon induced with helicase C domain 1 |
decreases expression |
ISO |
licochalcone B results in decreased expression of IFIH1 mRNA |
CTD |
PMID:33647349 |
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NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
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Igsf11 |
immunoglobulin superfamily, member 11 |
increases expression |
ISO |
licochalcone B results in increased expression of IGSF11 mRNA |
CTD |
PMID:33647349 |
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NCBI chr11:61,733,139...61,884,059
Ensembl chr11:61,733,144...61,868,348
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Il1a |
interleukin 1 alpha |
decreases expression |
ISO |
licochalcone B results in decreased expression of IL1A mRNA |
CTD |
PMID:33647349 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b |
interleukin 1 beta |
decreases expression multiple interactions |
ISO |
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