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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:misonidazole
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Accession:CHEBI:230671 term browser browse the term
Synonyms:exact_synonym: 1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol
 related_synonym: Formula=C7H11N3O4;   InChI=1S/C7H11N3O4/c1-14-5-6(11)4-9-3-2-8-7(9)10(12)13/h2-3,6,11H,4-5H2,1H3;   InChIKey=OBBCSXFCDPPXOL-UHFFFAOYSA-N;   SMILES=OC(CN1C(=NC=C1)[N+]([O-])=O)COC
 xref: Chemspider:24317;   DrugBank:DB11716;   HMDB:HMDB0254755;   KEGG:D05052
 xref_mesh: MESH:D008920



show annotations for term's descendants           Sort by:
misonidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase affects response to substance ISO CAT protein affects the susceptibility to Misonidazole CTD PMID:2943713 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Glb1 galactosidase, beta 1 increases activity EXP Misonidazole results in increased activity of GLB1 protein CTD PMID:7459223 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
JBrowse link
G Gss glutathione synthetase increases response to substance ISO GSS gene mutant form results in increased susceptibility to Misonidazole CTD PMID:3874843 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gusb glucuronidase, beta increases activity
multiple interactions
EXP
ISO
Misonidazole results in increased activity of GUSB protein
Dexamethasone inhibits the reaction [Misonidazole results in increased activity of GUSB protein]; Flurbiprofen inhibits the reaction [Misonidazole results in increased activity of GUSB protein]; Phenytoin inhibits the reaction [Misonidazole results in increased activity of GUSB protein]
CTD PMID:6696821 PMID:7073948 PMID:7107415 PMID:7459223 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
increases metabolic processing
EXP desmethylmisonidazole inhibits the reaction [POR protein results in increased metabolism of Misonidazole]; Flavins promotes the reaction [POR protein results in increased metabolism of Misonidazole]; Nitrofurantoin inhibits the reaction [POR protein results in increased metabolism of Misonidazole]; Nitrofurazone inhibits the reaction [POR protein results in increased metabolism of Misonidazole]; Paraquat promotes the reaction [POR protein results in increased metabolism of Misonidazole] CTD PMID:6802140 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Th tyrosine hydroxylase increases expression
increases activity
ISO Misonidazole results in increased expression of TH protein
Misonidazole results in increased activity of TH protein
CTD PMID:2875048 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      atom 19872
        nonmetal atom 19794
          carbon atom 19748
            organic molecular entity 19748
              misonidazole 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            misonidazole 6
paths to the root