|
G |
Atf3 |
activating transcription factor 3 |
multiple interactions increases expression |
ISO |
[[apilimod results in decreased activity of PIKFYVE protein] which results in increased expression of ATF3 protein] inhibits the reaction [IRF7 protein results in increased expression of IFNB1 mRNA] apilimod results in increased expression of ATF3 mRNA; apilimod results in increased expression of ATF3 protein |
CTD |
PMID:24600036 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
|
|
G |
Clcn7 |
chloride voltage-gated channel 7 |
affects response to substance |
ISO |
CLCN7 protein affects the susceptibility to apilimod |
CTD |
PMID:28104689 PMID:28350209 |
|
NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130
|
|
G |
Ifnb1 |
interferon beta 1 |
multiple interactions |
ISO |
apilimod inhibits the reaction [CpG ODN 1826 results in increased secretion of IFNB1 protein]; apilimod inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; apilimod inhibits the reaction [resiquimod results in increased expression of IFNB1 mRNA]; apilimod inhibits the reaction [resiquimod results in increased secretion of IFNB1 protein] [[apilimod results in decreased activity of PIKFYVE protein] which results in increased expression of ATF3 protein] inhibits the reaction [IRF7 protein results in increased expression of IFNB1 mRNA] |
CTD |
PMID:24600036 |
|
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
|
|
G |
Ifng |
interferon gamma |
multiple interactions decreases secretion decreases expression |
ISO |
apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL12A protein binds to IL12B protein]]; apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL23A protein binds to IL12B protein]]; apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of IL10 protein]; apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of IL12B protein]; apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein] apilimod results in decreased secretion of IFNG protein apilimod results in decreased expression of IFNG mRNA |
CTD |
PMID:17053051 PMID:21348542 PMID:23890009 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Il10 |
interleukin 10 |
increases expression multiple interactions |
ISO |
apilimod results in increased expression of IL10 mRNA apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of IL10 protein] |
CTD |
PMID:17053051 PMID:21348542 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
|
|
G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:17053051 |
|
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
|
|
G |
Il12b |
interleukin 12B |
decreases expression multiple interactions |
ISO |
apilimod results in decreased expression of IL12B mRNA apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL12A protein binds to IL12B protein]]; apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL23A protein binds to IL12B protein]]; apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of IL12B protein] |
CTD |
PMID:17053051 PMID:21348542 PMID:23890009 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
|
|
G |
Il17a |
interleukin 17A |
decreases expression |
ISO |
apilimod results in decreased expression of IL17A mRNA |
CTD |
PMID:21348542 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
|
|
G |
Il23a |
interleukin 23 subunit alpha |
decreases expression multiple interactions |
ISO |
apilimod results in decreased expression of IL23A mRNA apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL23A protein binds to IL12B protein]] |
CTD |
PMID:17053051 PMID:21348542 |
|
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein] |
CTD |
PMID:17053051 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Irf7 |
interferon regulatory factor 7 |
multiple interactions |
ISO |
[[apilimod results in decreased activity of PIKFYVE protein] which results in increased expression of ATF3 protein] inhibits the reaction [IRF7 protein results in increased expression of IFNB1 mRNA] |
CTD |
PMID:24600036 |
|
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
|
|
G |
Krt16 |
keratin 16 |
decreases expression |
ISO |
apilimod results in decreased expression of KRT16 mRNA |
CTD |
PMID:21348542 |
|
NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799
|
|
G |
Map1lc3a |
microtubule-associated protein 1 light chain 3 alpha |
increases expression |
ISO |
apilimod results in increased expression of MAP1LC3A protein |
CTD |
PMID:27438886 PMID:28104689 |
|
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
|
|
G |
Nbr1 |
NBR1, autophagy cargo receptor |
increases expression |
ISO |
apilimod results in increased expression of NBR1 protein |
CTD |
PMID:27438886 |
|
NCBI chr10:86,477,775...86,506,418
Ensembl chr10:86,478,290...86,506,412
|
|
G |
Nos2 |
nitric oxide synthase 2 |
decreases expression |
ISO |
apilimod results in decreased expression of NOS2 mRNA |
CTD |
PMID:21348542 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Ostm1 |
osteoclastogenesis associated transmembrane protein 1 |
affects response to substance |
ISO |
OSTM1 protein affects the susceptibility to apilimod |
CTD |
PMID:28104689 PMID:28350209 |
|
NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023
|
|
G |
Pikfyve |
phosphoinositide kinase, FYVE-type zinc finger containing |
decreases response to substance decreases activity multiple interactions affects binding |
ISO EXP |
PIKFYVE protein mutant form results in decreased susceptibility to apilimod apilimod results in decreased activity of PIKFYVE protein [[apilimod results in decreased activity of PIKFYVE protein] which results in increased expression of ATF3 protein] inhibits the reaction [IRF7 protein results in increased expression of IFNB1 mRNA]; apilimod binds to and results in decreased activity of PIKFYVE protein apilimod binds to PIKFYVE protein |
CTD |
PMID:23890009 PMID:24600036 PMID:27438886 PMID:28104689 PMID:28403145 PMID:30240452 PMID:32707573 PMID:32764148 More...
|
|
NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868
|
|
G |
Rac1 |
Rac family small GTPase 1 |
multiple interactions |
ISO |
apilimod inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein] |
CTD |
PMID:28779020 |
|
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
|
|
G |
Rac2 |
Rac family small GTPase 2 |
multiple interactions |
ISO |
apilimod inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein] |
CTD |
PMID:28779020 |
|
NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
|
|
G |
Snx10 |
sorting nexin 10 |
affects response to substance |
ISO |
SNX10 protein affects the susceptibility to apilimod |
CTD |
PMID:28104689 PMID:28350209 |
|
NCBI chr 4:80,612,648...80,677,005
Ensembl chr 4:80,612,669...80,676,996
|
|
G |
Sqstm1 |
sequestosome 1 |
increases expression |
ISO |
apilimod results in increased expression of SQSTM1 protein |
CTD |
PMID:27438886 PMID:28104689 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
|
|
G |
Tfeb |
transcription factor EB |
affects response to substance increases response to substance affects localization multiple interactions |
ISO |
TFEB protein affects the susceptibility to apilimod TFEB protein results in increased susceptibility to apilimod apilimod affects the localization of TFEB protein apilimod results in decreased phosphorylation of and affects the localization of TFEB protein |
CTD |
PMID:28104689 PMID:28350209 |
|
NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
|
|
G |
Tnf |
tumor necrosis factor |
decreases expression |
ISO |
apilimod results in decreased expression of TNF mRNA |
CTD |
PMID:21348542 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Wipi2 |
WD repeat domain, phosphoinositide interacting 2 |
increases expression |
ISO |
apilimod results in increased expression of WIPI2 protein |
CTD |
PMID:27438886 |
|
NCBI chr12:11,911,369...11,939,799
Ensembl chr12:11,911,337...11,939,794
|
|