CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: carbonates
Accession: CHEBI:23016
browse the term
Definition: Organooxygen compounds that are salts or esters of carbonic acid, H2CO3.
Synonyms: xref_mesh: MESH:D002254
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Ca1
carbonic anhydrase 1
decreases activity
ISO
Carbonates results in decreased activity of CA1 protein
CTD
PMID:15664814
NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454
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Ca4
carbonic anhydrase 4
decreases activity
ISO
Carbonates results in decreased activity of CA4 protein
CTD
PMID:15664814
NCBI chr10:70,325,102...70,333,916
Ensembl chr10:70,325,358...70,333,916
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Ca5a
carbonic anhydrase 5A
decreases activity
ISO
Carbonates results in decreased activity of CA5A protein
CTD
PMID:15664814
NCBI chr19:66,881,678...66,911,486
Ensembl chr19:66,881,693...66,911,486
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Ca9
carbonic anhydrase 9
decreases activity
ISO
Carbonates results in decreased activity of CA9 protein
CTD
PMID:15664814
NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626
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Car2
carbonic anhydrase 2
decreases activity
ISO
Carbonates results in decreased activity of CA2 protein
CTD
PMID:15664814
NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064
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Cbs
cystathionine beta synthase
decreases activity
ISO
Carbonates analog results in decreased activity of CBS protein
CTD
PMID:19733148
NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,709,395...9,734,066
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Sod1
superoxide dismutase 1
multiple interactions
ISO
[[[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid] which results in increased chemical synthesis of Carbonates; [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide]] which results in increased chemical synthesis of Carbonates
CTD
PMID:19243126
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
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Ahr
aryl hydrocarbon receptor
affects activity
ISO
adefovir dipivoxil affects the activity of AHR protein
CTD
PMID:25596134
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
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Ak4
adenylate kinase 4
increases expression
ISO
adefovir dipivoxil results in increased expression of AK4 mRNA
CTD
PMID:25596134
NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:121,154,572...121,214,401
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Akr1c2
aldo-keto reductase family 1, member C2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of AKR1C2 mRNA
CTD
PMID:25596134
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:70,669,710...70,685,686
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Aldh18a1
aldehyde dehydrogenase 18 family, member A1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of ALDH18A1 mRNA
CTD
PMID:25596134
NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:249,325,082...249,357,383
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Aldh1a3
aldehyde dehydrogenase 1 family, member A3
increases expression
ISO
adefovir dipivoxil results in increased expression of ALDH1A3 mRNA
CTD
PMID:25596134
NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777
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Als2cl
ALS2 C-terminal like
increases expression
ISO
adefovir dipivoxil results in increased expression of ALS2CL mRNA
CTD
PMID:25596134
NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:119,743,248...119,762,843
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Angptl4
angiopoietin-like 4
increases expression
ISO
adefovir dipivoxil results in increased expression of ANGPTL4 mRNA
CTD
PMID:25596134
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:15,252,473...15,258,681
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Asns
asparagine synthetase (glutamine-hydrolyzing)
decreases expression
ISO
adefovir dipivoxil results in decreased expression of ASNS mRNA
CTD
PMID:25596134
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:36,751,802...36,776,050
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Atad2
ATPase family, AAA domain containing 2
increases expression
ISO
adefovir dipivoxil results in increased expression of ATAD2 mRNA
CTD
PMID:25596134
NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:91,523,626...91,566,238
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Atf3
activating transcription factor 3
increases expression
ISO
adefovir dipivoxil results in increased expression of ATF3 mRNA
CTD
PMID:25596134
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:105,282,440...105,295,750
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Aurkb
aurora kinase B
increases expression
ISO
adefovir dipivoxil results in increased expression of AURKB mRNA
CTD
PMID:25596134
NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285
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Axl
Axl receptor tyrosine kinase
increases expression
ISO
adefovir dipivoxil results in increased expression of AXL mRNA
CTD
PMID:25596134
NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
adefovir dipivoxil results in increased expression of BAX mRNA
CTD
PMID:25596134
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bcar3
BCAR3 adaptor protein, NSP family member
increases expression
ISO
adefovir dipivoxil results in increased expression of BCAR3 mRNA
CTD
PMID:25596134
NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:213,209,893...213,323,302
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Bend5
BEN domain containing 5
decreases expression
ISO
adefovir dipivoxil results in decreased expression of BEND5 mRNA
CTD
PMID:25596134
NCBI chr 5:131,519,214...131,565,228
Ensembl chr 5:131,519,214...131,762,906
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Bmf
Bcl2 modifying factor
decreases expression
ISO
adefovir dipivoxil results in decreased expression of BMF mRNA
CTD
PMID:25596134
NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
adefovir dipivoxil results in increased expression of BTG2 mRNA
CTD
PMID:25596134
NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690
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Ccne2
cyclin E2
increases expression
ISO
adefovir dipivoxil results in increased expression of CCNE2 mRNA
CTD
PMID:25596134
NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882
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Cdk6
cyclin-dependent kinase 6
increases expression
ISO
adefovir dipivoxil results in increased expression of CDK6 mRNA
CTD
PMID:25596134
NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
adefovir dipivoxil results in increased expression of CDKN1A mRNA
CTD
PMID:25596134
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
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Cmbl
carboxymethylenebutenolidase homolog
increases expression
ISO
adefovir dipivoxil results in increased expression of CMBL mRNA
CTD
PMID:25596134
NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:84,242,512...84,301,880
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Coch
cochlin
increases expression
ISO
adefovir dipivoxil results in increased expression of COCH mRNA
CTD
PMID:25596134
NCBI chr 6:74,766,485...74,780,504
Ensembl chr 6:74,766,419...74,780,502
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Col4a1
collagen type IV alpha 1 chain
decreases expression
ISO
adefovir dipivoxil results in decreased expression of COL4A1 mRNA
CTD
PMID:25596134
NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482
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Cth
cystathionine gamma-lyase
decreases expression
ISO
adefovir dipivoxil results in decreased expression of CTH mRNA
CTD
PMID:25596134
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:249,634,731...249,661,066
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Ctsc
cathepsin C
decreases expression
ISO
adefovir dipivoxil results in decreased expression of CTSC mRNA
CTD
PMID:25596134
NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
adefovir dipivoxil results in increased expression of CYP1B1 mRNA
CTD
PMID:25596134
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
adefovir dipivoxil results in decreased activity of CYP3A4 protein
CTD
PMID:17162464
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
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Ddb2
damage specific DNA binding protein 2
increases expression
ISO
adefovir dipivoxil results in increased expression of DDB2 mRNA
CTD
PMID:25596134
NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:97,640,579...97,664,066
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Dgka
diacylglycerol kinase, alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of DGKA mRNA
CTD
PMID:25596134
NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,733,248...1,759,569
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Dlgap5
DLG associated protein 5
increases expression
ISO
adefovir dipivoxil results in increased expression of DLGAP5 mRNA
CTD
PMID:25596134
NCBI chr15:23,113,678...23,144,281
Ensembl chr15:23,113,678...23,144,176
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Dlx1
distal-less homeobox 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of DLX1 mRNA
CTD
PMID:25596134
NCBI chr 3:76,763,864...76,768,454
Ensembl chr 3:76,763,500...76,768,447
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Dnai3
dynein axonemal intermediate chain 3
increases expression
ISO
adefovir dipivoxil results in increased expression of DNAI3 mRNA
CTD
PMID:25596134
NCBI chr 2:237,608,202...237,666,465
Ensembl chr 2:237,604,068...237,666,465
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Dpysl3
dihydropyrimidinase-like 3
increases expression
ISO
adefovir dipivoxil results in increased expression of DPYSL3 mRNA
CTD
PMID:25596134
NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,625,357...35,731,152
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Efna1
ephrin A1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of EFNA1 mRNA
CTD
PMID:25596134
NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726
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Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of ERO1A mRNA
CTD
PMID:25596134
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:20,972,679...21,018,039
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Fas
Fas cell surface death receptor
increases expression
ISO
adefovir dipivoxil results in increased expression of FAS mRNA
CTD
PMID:25596134
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
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Fbxo22
F-box protein 22
increases expression
ISO
adefovir dipivoxil results in increased expression of FBXO22 mRNA
CTD
PMID:25596134
NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:64,475,957...64,492,062
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Gabarapl1
GABA type A receptor associated protein like 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GABARAPL1 mRNA
CTD
PMID:25596134
NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:164,666,246...164,674,578
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of GADD45A mRNA
CTD
PMID:25596134
NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807
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Galnt16
polypeptide N-acetylgalactosaminyltransferase 16
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GALNT16 mRNA
CTD
PMID:25596134
NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:105,901,153...105,991,350
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Gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
increases expression
ISO
adefovir dipivoxil results in increased expression of GCNT3 mRNA
CTD
PMID:25596134
NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:79,566,753...79,581,595
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Gdf15
growth differentiation factor 15
increases expression
ISO
adefovir dipivoxil results in increased expression of GDF15 mRNA
CTD
PMID:25596134
NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022
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Got1
glutamic-oxaloacetic transaminase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GOT1 mRNA
CTD
PMID:25596134
NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871
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Gpr87
G protein-coupled receptor 87
increases expression
ISO
adefovir dipivoxil results in increased expression of GPR87 mRNA
CTD
PMID:25596134
NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:145,589,569...145,604,442
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H1f2
H1.2 linker histone, cluster member
increases expression
ISO
adefovir dipivoxil results in increased expression of H1-2 mRNA
CTD
PMID:25596134
NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,779,051...41,822,317
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Hmox1
heme oxygenase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of HMOX1 mRNA
CTD
PMID:25596134
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
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Hspa1b
heat shock protein family A (Hsp70) member 1B
decreases expression
ISO
adefovir dipivoxil results in decreased expression of HSPA1B mRNA
CTD
PMID:25596134
NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979
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Ifng
interferon gamma
multiple interactions
ISO
adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:9354585
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
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Il19
interleukin 19
increases secretion
ISO
adefovir dipivoxil results in increased secretion of IL19 protein
CTD
PMID:24714768
NCBI chr13:44,949,989...44,958,714
Ensembl chr13:44,949,989...44,958,714
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Kat6b
lysine acetyltransferase 6B
decreases expression
ISO
adefovir dipivoxil results in decreased expression of KAT6B mRNA
CTD
PMID:25596134
NCBI chr15:2,688,535...2,861,443
Ensembl chr15:2,688,811...2,844,343
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Kdm3a
lysine demethylase 3A
decreases expression
ISO
adefovir dipivoxil results in decreased expression of KDM3A mRNA
CTD
PMID:25596134
NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:105,189,208...105,233,370
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Krt15
keratin 15
increases expression
ISO
adefovir dipivoxil results in increased expression of KRT15 mRNA
CTD
PMID:25596134
NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,567,202...85,571,142
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Lama3
laminin subunit alpha 3
increases expression
ISO
adefovir dipivoxil results in increased expression of LAMA3 mRNA
CTD
PMID:25596134
NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,797,939...4,026,449
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Lcn2
lipocalin 2
increases secretion
ISO
adefovir dipivoxil results in increased secretion of LCN2 protein
CTD
PMID:24714768
NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842
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Map3k8
mitogen-activated protein kinase kinase kinase 8
increases expression
ISO
adefovir dipivoxil results in increased expression of MAP3K8 mRNA
CTD
PMID:25596134
NCBI chr17:53,382,908...53,403,216
Ensembl chr17:58,078,320...58,098,452
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Mdm2
MDM2 proto-oncogene
increases expression
ISO
adefovir dipivoxil results in increased expression of MDM2 mRNA
CTD
PMID:25596134
NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791
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Mxi1
MAX interactor 1, dimerization protein
decreases expression
ISO
adefovir dipivoxil results in decreased expression of MXI1 mRNA
CTD
PMID:25596134
NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:262,328,875...262,389,036
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Ncapd2
non-SMC condensin I complex, subunit D2
increases expression
ISO
adefovir dipivoxil results in increased expression of NCAPD2 mRNA
CTD
PMID:25596134
NCBI chr 4:159,655,051...159,677,938
Ensembl chr 4:159,655,051...159,677,938
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Ninj1
ninjurin 1
increases expression
ISO
adefovir dipivoxil results in increased expression of NINJ1 mRNA
CTD
PMID:25596134
NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,659,200...15,668,063
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:9354585
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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Nqo1
NAD(P)H quinone dehydrogenase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of NQO1 mRNA
CTD
PMID:25596134
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
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Nrep
neuronal regeneration related protein
decreases expression
ISO
adefovir dipivoxil results in decreased expression of NREP mRNA
CTD
PMID:25596134
NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,291,219...25,320,742
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Ntpcr
nucleoside-triphosphatase, cancer-related
increases expression
ISO
adefovir dipivoxil results in increased expression of NTPCR mRNA
CTD
PMID:25596134
NCBI chr19:53,701,496...53,715,260
Ensembl chr19:70,593,274...70,613,197
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P4ha1
prolyl 4-hydroxylase subunit alpha 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of P4HA1 mRNA
CTD
PMID:25596134
NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,845,141...27,895,404
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Pank1
pantothenate kinase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PANK1 mRNA
CTD
PMID:25596134
NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:241,741,083...241,807,824
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Pdia5
protein disulfide isomerase family A, member 5
increases expression
ISO
adefovir dipivoxil results in increased expression of PDIA5 mRNA
CTD
PMID:25596134
NCBI chr11:65,272,152...65,359,087
Ensembl chr11:78,777,419...78,864,329
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Pdlim1
PDZ and LIM domain 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PDLIM1 mRNA
CTD
PMID:25596134
NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:248,991,818...249,047,379
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Pgr
progesterone receptor
multiple interactions
ISO
adefovir dipivoxil binds to and results in decreased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:14,354,398...14,413,271
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Phlda3
pleckstrin homology-like domain, family A, member 3
increases expression
ISO
adefovir dipivoxil results in increased expression of PHLDA3 mRNA
CTD
PMID:25596134
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:49,742,591...49,749,621
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Pidd1
p53-induced death domain protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PIDD1 mRNA
CTD
PMID:25596134
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:205,966,392...205,971,600
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Pir
pirin
increases expression
ISO
adefovir dipivoxil results in increased expression of PIR mRNA
CTD
PMID:25596134
NCBI chr X:30,108,536...30,219,269
Ensembl chr X:33,740,429...33,851,049
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Plec
plectin
increases expression
ISO
adefovir dipivoxil results in increased expression of PLEC mRNA
CTD
PMID:25596134
NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:109,768,447...109,828,089
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PMAIP1 mRNA
CTD
PMID:25596134
NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382
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Pparg
peroxisome proliferator-activated receptor gamma
affects activity
ISO
adefovir dipivoxil affects the activity of PPARG protein
CTD
PMID:25596134
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
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Ppm1d
protein phosphatase, Mg2+/Mn2+ dependent, 1D
increases expression
ISO
adefovir dipivoxil results in increased expression of PPM1D mRNA
CTD
PMID:25596134
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,670,020...70,706,256
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Prc1
protein regulator of cytokinesis 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PRC1 mRNA
CTD
PMID:25596134
NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:143,659,481...143,681,012
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Prdm1
PR/SET domain 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PRDM1 mRNA
CTD
PMID:25596134
NCBI chr20:49,542,465...49,564,088
Ensembl chr20:49,542,465...49,564,088
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Prkab2
protein kinase AMP-activated non-catalytic subunit beta 2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PRKAB2 mRNA
CTD
PMID:25596134
NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:187,945,982...187,961,608
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Psat1
phosphoserine aminotransferase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PSAT1 mRNA
CTD
PMID:25596134
NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693
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Rara
retinoic acid receptor, alpha
decreases expression
ISO
adefovir dipivoxil results in decreased expression of RARA mRNA
CTD
PMID:25596134
NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160
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Rps27l
ribosomal protein S27-like
increases expression
ISO
adefovir dipivoxil results in increased expression of RPS27L mRNA
CTD
PMID:25596134
NCBI chr 8:67,562,483...67,567,418
Ensembl chr12:33,713,661...33,714,130 Ensembl chr 8:33,713,661...33,714,130
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Rrm2b
ribonucleotide reductase regulatory TP53 inducible subunit M2B
increases expression
ISO
adefovir dipivoxil results in increased expression of RRM2B mRNA
CTD
PMID:25596134
NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:70,965,590...70,993,670
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Serpinb5
serpin family B member 5
increases expression
ISO
adefovir dipivoxil results in increased expression of SERPINB5 mRNA
CTD
PMID:25596134
NCBI chr13:22,985,557...23,005,756
Ensembl chr13:23,500,198...23,520,400
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Sesn1
sestrin 1
increases expression
ISO
adefovir dipivoxil results in increased expression of SESN1 mRNA
CTD
PMID:25596134
NCBI chr20:45,294,876...45,387,698
Ensembl chr20:46,876,895...46,970,010
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Sfn
stratifin
increases expression
ISO
adefovir dipivoxil results in increased expression of SFN mRNA
CTD
PMID:25596134
NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:151,110,530...151,111,995
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Sh3tc1
SH3 domain and tetratricopeptide repeats 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SH3TC1 mRNA
CTD
PMID:25596134
NCBI chr14:75,005,691...75,050,001
Ensembl chr14:79,230,371...79,274,620
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Slc27a2
solute carrier family 27 member 2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SLC27A2 mRNA
CTD
PMID:25596134
NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581
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Slc6a9
solute carrier family 6 member 9
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SLC6A9 mRNA
CTD
PMID:25596134
NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:136,659,948...136,694,172
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Slco2b1
solute carrier organic anion transporter family, member 2b1
increases expression
ISO
adefovir dipivoxil results in increased expression of SLCO2B1 mRNA
CTD
PMID:25596134
NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:163,371,410...163,419,279
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Smap1
small ArfGAP 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SMAP1 mRNA
CTD
PMID:25596134
NCBI chr 9:26,250,178...26,342,151
Ensembl chr 9:33,746,489...33,838,734
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Sulf2
sulfatase 2
increases expression
ISO
adefovir dipivoxil results in increased expression of SULF2 mRNA
CTD
PMID:25596134
NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:175,241,322...175,323,651
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Thra
thyroid hormone receptor alpha
multiple interactions
ISO
adefovir dipivoxil binds to and results in decreased activity of THRA protein
CTD
PMID:25752796
NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657
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Tigar
TP53 induced glycolysis regulatory phosphatase
increases expression
ISO
adefovir dipivoxil results in increased expression of TIGAR mRNA
CTD
PMID:25596134
NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:161,613,306...161,632,229
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
increases expression
ISO
adefovir dipivoxil results in increased expression of TIPARP mRNA
CTD
PMID:25596134
NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:152,063,751...152,090,406
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Tnfsf9
TNF superfamily member 9
increases expression
ISO
adefovir dipivoxil results in increased expression of TNFSF9 mRNA
CTD
PMID:25596134
NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:2,030,953...2,033,339
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Tp53
tumor protein p53
affects activity
ISO
adefovir dipivoxil affects the activity of TP53 protein
CTD
PMID:25596134 PMID:35435491
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
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Tp53inp1
tumor protein p53 inducible nuclear protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of TP53INP1 mRNA
CTD
PMID:25596134
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:29,051,264...29,069,484
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Trafd1
TRAF type zinc finger domain containing 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of TRAFD1 mRNA
CTD
PMID:25596134
NCBI chr12:35,165,606...35,179,525
Ensembl chr12:40,825,851...40,841,320
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Triap1
TP53 regulated inhibitor of apoptosis 1
increases expression
ISO
adefovir dipivoxil results in increased expression of TRIAP1 mRNA
CTD
PMID:25596134
NCBI chr12:46,928,273...46,930,766
Ensembl chr12:46,928,273...46,930,766
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Ube2o
ubiquitin-conjugating enzyme E2O
decreases expression
ISO
adefovir dipivoxil results in decreased expression of UBE2O mRNA
CTD
PMID:25596134
NCBI chr10:101,765,572...101,812,736
Ensembl chr10:102,264,418...102,311,549
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Yars1
tyrosyl-tRNA synthetase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of YARS1 mRNA
CTD
PMID:25596134
NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:146,819,358...146,848,377
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Zmat3
zinc finger, matrin type 3
increases expression
ISO
adefovir dipivoxil results in increased expression of ZMAT3 mRNA
CTD
PMID:25596134
NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:117,034,517...117,065,294
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Bglap
bone gamma-carboxyglutamate protein
decreases expression
ISO
Calcium Carbonate results in decreased expression of BGLAP protein
CTD
PMID:2027271
NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
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Capn1
calpain 1
increases activity
ISO
Calcium Carbonate analog results in increased activity of CAPN1 protein
CTD
PMID:24412303
NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:212,705,222...212,729,445
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Casp3
caspase 3
increases activity
ISO
Calcium Carbonate analog results in increased activity of CASP3 protein
CTD
PMID:24412303
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Calcium Carbonate analog results in increased expression of DDIT3
CTD
PMID:24412303
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
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Pth
parathyroid hormone
affects expression decreases expression
ISO
Calcium Carbonate affects the expression of PTH protein Calcium Carbonate results in decreased expression of PTH protein
CTD
PMID:1752077 PMID:2027271 PMID:3826069 PMID:7891547 PMID:8481062 PMID:16006300 More...
NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:176,943,102...176,946,034
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Pthlh
parathyroid hormone-like hormone
decreases expression
ISO
Calcium Carbonate results in decreased expression of PTHLH protein
CTD
PMID:16006300
NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454
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Spp1
secreted phosphoprotein 1
decreases expression
ISO
Calcium Carbonate results in decreased expression of SPP1 protein
CTD
PMID:17977878
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
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Alad
aminolevulinate dehydratase
multiple interactions decreases activity
EXP
Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of ALAD protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of ALAD protein]; Zinc Sulfate inhibits the reaction [Lithium Carbonate results in decreased activity of ALAD protein]
CTD
PMID:19083387 PMID:28988373
NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041
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Casp1
caspase 1
increases expression
ISO
Lithium Carbonate results in increased expression of CASP1 protein
CTD
PMID:34984798
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:10,746,333...10,882,275
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Casp3
caspase 3
increases activity multiple interactions increases expression
EXP ISO
Lithium Carbonate results in increased activity of CASP3 protein Butylated Hydroxytoluene inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein] Lithium Carbonate results in increased expression of CASP3 protein
CTD
PMID:27588890 PMID:34984798
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Casp6
caspase 6
increases expression
ISO
Lithium Carbonate results in increased expression of CASP6 protein
CTD
PMID:34984798
NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726
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Casp7
caspase 7
increases expression
ISO
Lithium Carbonate results in increased expression of CASP7 protein
CTD
PMID:34984798
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:265,442,676...265,482,512
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Casp9
caspase 9
increases expression
ISO
Lithium Carbonate results in increased expression of CASP9 protein
CTD
PMID:34984798
Ensembl chr 5:159,391,188...159,409,648
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Cat
catalase
decreases activity multiple interactions
EXP ISO
Lithium Carbonate results in decreased activity of CAT protein Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of CAT protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of CAT protein]
CTD
PMID:28988373 PMID:34984798
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
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Gsr
glutathione-disulfide reductase
multiple interactions decreases activity
EXP
Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of GSR protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of GSR protein]
CTD
PMID:28988373
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:65,185,574...65,228,394
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Ifng
interferon gamma
multiple interactions
ISO
[Lithium Carbonate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
CTD
PMID:29594315
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
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Il1b
interleukin 1 beta
decreases expression increases expression
ISO
Lithium Carbonate results in decreased expression of IL1B mRNA Lithium Carbonate results in increased expression of IL1B mRNA; Lithium Carbonate results in increased expression of IL1B protein
CTD
PMID:29594315 PMID:34984798
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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Il2
interleukin 2
multiple interactions
ISO
[Lithium Carbonate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:29594315
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
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Ins1
insulin 1
decreases expression multiple interactions
EXP
Lithium Carbonate results in decreased expression of INS1 protein Lithium Carbonate inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
CTD
PMID:10700396
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
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Mir21
microRNA 21
multiple interactions
EXP
[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of MIR21 mRNA; Acetylcysteine inhibits the reaction [[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of MIR21 mRNA]
CTD
PMID:31928237
NCBI chr10:71,902,600...71,902,691
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Mir29b1
microRNA 29b-1
multiple interactions
EXP
[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of MIR29B1 mRNA; Acetylcysteine inhibits the reaction [[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of MIR29B1 mRNA]
CTD
PMID:31928237
NCBI chr 4:59,650,987...59,651,067
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Nfkbia
NFKB inhibitor alpha
increases phosphorylation
ISO
Lithium Carbonate results in increased phosphorylation of NFKBIA protein
CTD
PMID:34984798
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
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Nlrp3
NLR family, pyrin domain containing 3
increases expression
ISO
Lithium Carbonate results in increased expression of NLRP3 protein
CTD
PMID:34984798
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
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Nos3
nitric oxide synthase 3
multiple interactions
EXP
[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of NOS3 protein; Acetylcysteine inhibits the reaction [[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of NOS3 protein]
CTD
PMID:31928237
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
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Pfkfb2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
decreases activity multiple interactions
EXP
Lithium Carbonate results in decreased activity of PFKFB2 protein Lithium Carbonate inhibits the reaction [Streptozocin results in decreased activity of PFKFB2 protein]
CTD
PMID:10700396
NCBI chr13:44,683,499...44,727,135
Ensembl chr13:44,699,744...44,726,971
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Pla2g4a
phospholipase A2 group 4A
increases expression
ISO
Lithium Carbonate results in increased expression of PLA2G4A mRNA; Lithium Carbonate results in increased expression of PLA2G4A protein
CTD
PMID:17594078
NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641
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Pth
parathyroid hormone
increases expression
ISO
Lithium Carbonate results in increased expression of PTH protein
CTD
PMID:3083797 PMID:18234408
NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:176,943,102...176,946,034
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Pycard
PYD and CARD domain containing
increases expression
ISO
Lithium Carbonate results in increased expression of PYCARD protein
CTD
PMID:34984798
NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419
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Rela
RELA proto-oncogene, NF-kB subunit
increases phosphorylation
ISO
Lithium Carbonate results in increased phosphorylation of RELA protein
CTD
PMID:34984798
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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Tnf
tumor necrosis factor
increases expression
ISO
Lithium Carbonate results in increased expression of TNF mRNA; Lithium Carbonate results in increased expression of TNF protein
CTD
PMID:34984798
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Tnni3
troponin I3, cardiac type
multiple interactions
EXP
[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of TNNI3 protein; Acetylcysteine inhibits the reaction [[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of TNNI3 protein]
CTD
PMID:31928237
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:78,342,592...78,346,253
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Ar
androgen receptor
multiple interactions
ISO
Loteprednol Etabonate binds to and results in decreased activity of AR protein; Loteprednol Etabonate binds to and results in increased activity of AR protein
CTD
PMID:25752796
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467
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Pgr
progesterone receptor
multiple interactions
ISO
Loteprednol Etabonate binds to and results in increased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:14,354,398...14,413,271
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Foxo1
forkhead box O1
increases expression
ISO
spirotetramat results in increased expression of FOXO1 mRNA
CTD
PMID:27917277
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419
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Vnn1
vanin 1
decreases expression
ISO
spirotetramat results in decreased expression of VNN1 mRNA
CTD
PMID:27917277
NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629
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