CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: carbonates
Accession: CHEBI:23016
browse the term
Definition: Organooxygen compounds that are salts or esters of carbonic acid, H2CO3.
Synonyms: xref_mesh: MESH:D002254
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Car1
carbonic anhydrase 1
decreases activity
ISO
Carbonates results in decreased activity of CA1 protein
CTD
PMID:15664814
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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Car2
carbonic anhydrase 2
decreases activity
ISO
Carbonates results in decreased activity of CA2 protein
CTD
PMID:15664814
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Car4
carbonic anhydrase 4
decreases activity
ISO
Carbonates results in decreased activity of CA4 protein
CTD
PMID:15664814
NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
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Car5a
carbonic anhydrase 5A
decreases activity
ISO
Carbonates results in decreased activity of CA5A protein
CTD
PMID:15664814
NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
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Car9
carbonic anhydrase 9
decreases activity
ISO
Carbonates results in decreased activity of CA9 protein
CTD
PMID:15664814
NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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Cbs
cystathionine beta synthase
decreases activity
ISO
Carbonates analog results in decreased activity of CBS protein
CTD
PMID:19733148
NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
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Sod1
superoxide dismutase 1
multiple interactions
ISO
[[[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid] which results in increased chemical synthesis of Carbonates; [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide]] which results in increased chemical synthesis of Carbonates
CTD
PMID:19243126
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Ahr
aryl hydrocarbon receptor
affects activity
ISO
adefovir dipivoxil affects the activity of AHR protein
CTD
PMID:25596134
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ak4
adenylate kinase 4
increases expression
ISO
adefovir dipivoxil results in increased expression of AK4 mRNA
CTD
PMID:25596134
NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
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Akr1c2
aldo-keto reductase family 1, member C2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of AKR1C2 mRNA
CTD
PMID:25596134
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Aldh18a1
aldehyde dehydrogenase 18 family, member A1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of ALDH18A1 mRNA
CTD
PMID:25596134
NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890
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Aldh1a3
aldehyde dehydrogenase 1 family, member A3
increases expression
ISO
adefovir dipivoxil results in increased expression of ALDH1A3 mRNA
CTD
PMID:25596134
NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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Als2cl
ALS2 C-terminal like
increases expression
ISO
adefovir dipivoxil results in increased expression of ALS2CL mRNA
CTD
PMID:25596134
NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:110,864,975...110,884,419
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Angptl4
angiopoietin-like 4
increases expression
ISO
adefovir dipivoxil results in increased expression of ANGPTL4 mRNA
CTD
PMID:25596134
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Asns
asparagine synthetase (glutamine-hydrolyzing)
decreases expression
ISO
adefovir dipivoxil results in decreased expression of ASNS mRNA
CTD
PMID:25596134
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Atad2
ATPase family, AAA domain containing 2
increases expression
ISO
adefovir dipivoxil results in increased expression of ATAD2 mRNA
CTD
PMID:25596134
NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
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Atf3
activating transcription factor 3
increases expression
ISO
adefovir dipivoxil results in increased expression of ATF3 mRNA
CTD
PMID:25596134
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Aurkb
aurora kinase B
increases expression
ISO
adefovir dipivoxil results in increased expression of AURKB mRNA
CTD
PMID:25596134
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Axl
Axl receptor tyrosine kinase
increases expression
ISO
adefovir dipivoxil results in increased expression of AXL mRNA
CTD
PMID:25596134
NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
adefovir dipivoxil results in increased expression of BAX mRNA
CTD
PMID:25596134
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcar3
BCAR3 adaptor protein, NSP family member
increases expression
ISO
adefovir dipivoxil results in increased expression of BCAR3 mRNA
CTD
PMID:25596134
NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
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Bend5
BEN domain containing 5
decreases expression
ISO
adefovir dipivoxil results in decreased expression of BEND5 mRNA
CTD
PMID:25596134
NCBI chr 5:126,290,648...126,336,662
Ensembl chr 5:125,254,956...126,534,367
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Bmf
Bcl2 modifying factor
decreases expression
ISO
adefovir dipivoxil results in decreased expression of BMF mRNA
CTD
PMID:25596134
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
adefovir dipivoxil results in increased expression of BTG2 mRNA
CTD
PMID:25596134
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Ccne2
cyclin E2
increases expression
ISO
adefovir dipivoxil results in increased expression of CCNE2 mRNA
CTD
PMID:25596134
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Cdk6
cyclin-dependent kinase 6
increases expression
ISO
adefovir dipivoxil results in increased expression of CDK6 mRNA
CTD
PMID:25596134
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
adefovir dipivoxil results in increased expression of CDKN1A mRNA
CTD
PMID:25596134
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cmbl
carboxymethylenebutenolidase homolog
increases expression
ISO
adefovir dipivoxil results in increased expression of CMBL mRNA
CTD
PMID:25596134
NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
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Coch
cochlin
increases expression
ISO
adefovir dipivoxil results in increased expression of COCH mRNA
CTD
PMID:25596134
NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109
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Col4a1
collagen type IV alpha 1 chain
decreases expression
ISO
adefovir dipivoxil results in decreased expression of COL4A1 mRNA
CTD
PMID:25596134
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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Cth
cystathionine gamma-lyase
decreases expression
ISO
adefovir dipivoxil results in decreased expression of CTH mRNA
CTD
PMID:25596134
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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Ctsc
cathepsin C
decreases expression
ISO
adefovir dipivoxil results in decreased expression of CTSC mRNA
CTD
PMID:25596134
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
adefovir dipivoxil results in increased expression of CYP1B1 mRNA
CTD
PMID:25596134
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
adefovir dipivoxil results in decreased activity of CYP3A4 protein
CTD
PMID:17162464
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Ddb2
damage specific DNA binding protein 2
increases expression
ISO
adefovir dipivoxil results in increased expression of DDB2 mRNA
CTD
PMID:25596134
NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
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Dgka
diacylglycerol kinase, alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of DGKA mRNA
CTD
PMID:25596134
NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
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Dlgap5
DLG associated protein 5
increases expression
ISO
adefovir dipivoxil results in increased expression of DLGAP5 mRNA
CTD
PMID:25596134
NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
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Dlx1
distal-less homeobox 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of DLX1 mRNA
CTD
PMID:25596134
NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780
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Dnai3
dynein axonemal intermediate chain 3
increases expression
ISO
adefovir dipivoxil results in increased expression of DNAI3 mRNA
CTD
PMID:25596134
NCBI chr 2:234,947,910...235,006,173
Ensembl chr 2:234,929,677...235,006,173
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Dpysl3
dihydropyrimidinase-like 3
increases expression
ISO
adefovir dipivoxil results in increased expression of DPYSL3 mRNA
CTD
PMID:25596134
NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157
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Efna1
ephrin A1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of EFNA1 mRNA
CTD
PMID:25596134
NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
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Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of ERO1A mRNA
CTD
PMID:25596134
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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Fas
Fas cell surface death receptor
increases expression
ISO
adefovir dipivoxil results in increased expression of FAS mRNA
CTD
PMID:25596134
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fbxo22
F-box protein 22
increases expression
ISO
adefovir dipivoxil results in increased expression of FBXO22 mRNA
CTD
PMID:25596134
NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
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Gabarapl1
GABA type A receptor associated protein like 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GABARAPL1 mRNA
CTD
PMID:25596134
NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of GADD45A mRNA
CTD
PMID:25596134
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Galnt16
polypeptide N-acetylgalactosaminyltransferase 16
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GALNT16 mRNA
CTD
PMID:25596134
NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705
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Gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
increases expression
ISO
adefovir dipivoxil results in increased expression of GCNT3 mRNA
CTD
PMID:25596134
NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
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Gdf15
growth differentiation factor 15
increases expression
ISO
adefovir dipivoxil results in increased expression of GDF15 mRNA
CTD
PMID:25596134
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Got1
glutamic-oxaloacetic transaminase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GOT1 mRNA
CTD
PMID:25596134
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpr87
G protein-coupled receptor 87
increases expression
ISO
adefovir dipivoxil results in increased expression of GPR87 mRNA
CTD
PMID:25596134
NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:143,439,735...143,458,190
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H1f2
H1.2 linker histone, cluster member
increases expression
ISO
adefovir dipivoxil results in increased expression of H1-2 mRNA
CTD
PMID:25596134
NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635
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Hmox1
heme oxygenase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of HMOX1 mRNA
CTD
PMID:25596134
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa1b
heat shock protein family A (Hsp70) member 1B
decreases expression
ISO
adefovir dipivoxil results in decreased expression of HSPA1B mRNA
CTD
PMID:25596134
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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Ifng
interferon gamma
multiple interactions
ISO
adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:9354585
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il19
interleukin 19
increases secretion
ISO
adefovir dipivoxil results in increased secretion of IL19 protein
CTD
PMID:24714768
NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
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Kat6b
lysine acetyltransferase 6B
decreases expression
ISO
adefovir dipivoxil results in decreased expression of KAT6B mRNA
CTD
PMID:25596134
NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316
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Kdm3a
lysine demethylase 3A
decreases expression
ISO
adefovir dipivoxil results in decreased expression of KDM3A mRNA
CTD
PMID:25596134
NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073
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Krt15
keratin 15
increases expression
ISO
adefovir dipivoxil results in increased expression of KRT15 mRNA
CTD
PMID:25596134
NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799
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Lama3
laminin subunit alpha 3
increases expression
ISO
adefovir dipivoxil results in increased expression of LAMA3 mRNA
CTD
PMID:25596134
NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
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Lcn2
lipocalin 2
increases secretion
ISO
adefovir dipivoxil results in increased secretion of LCN2 protein
CTD
PMID:24714768
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Map3k8
mitogen-activated protein kinase kinase kinase 8
increases expression
ISO
adefovir dipivoxil results in increased expression of MAP3K8 mRNA
CTD
PMID:25596134
NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
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Mdm2
MDM2 proto-oncogene
increases expression
ISO
adefovir dipivoxil results in increased expression of MDM2 mRNA
CTD
PMID:25596134
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Mxi1
MAX interactor 1, dimerization protein
decreases expression
ISO
adefovir dipivoxil results in decreased expression of MXI1 mRNA
CTD
PMID:25596134
NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
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Ncapd2
non-SMC condensin I complex, subunit D2
increases expression
ISO
adefovir dipivoxil results in increased expression of NCAPD2 mRNA
CTD
PMID:25596134
NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020
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Ninj1
ninjurin 1
increases expression
ISO
adefovir dipivoxil results in increased expression of NINJ1 mRNA
CTD
PMID:25596134
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:9354585
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of NQO1 mRNA
CTD
PMID:25596134
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nrep
neuronal regeneration related protein
decreases expression
ISO
adefovir dipivoxil results in decreased expression of NREP mRNA
CTD
PMID:25596134
NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
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Ntpcr
nucleoside-triphosphatase, cancer-related
increases expression
ISO
adefovir dipivoxil results in increased expression of NTPCR mRNA
CTD
PMID:25596134
NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202
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P4ha1
prolyl 4-hydroxylase subunit alpha 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of P4HA1 mRNA
CTD
PMID:25596134
NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
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Pank1
pantothenate kinase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PANK1 mRNA
CTD
PMID:25596134
NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829
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Pdia5
protein disulfide isomerase family A, member 5
increases expression
ISO
adefovir dipivoxil results in increased expression of PDIA5 mRNA
CTD
PMID:25596134
NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084
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Pdlim1
PDZ and LIM domain 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PDLIM1 mRNA
CTD
PMID:25596134
NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
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Pgr
progesterone receptor
multiple interactions
ISO
adefovir dipivoxil binds to and results in decreased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Phlda3
pleckstrin homology-like domain, family A, member 3
increases expression
ISO
adefovir dipivoxil results in increased expression of PHLDA3 mRNA
CTD
PMID:25596134
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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Pidd1
p53-induced death domain protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PIDD1 mRNA
CTD
PMID:25596134
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
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Pir
pirin
increases expression
ISO
adefovir dipivoxil results in increased expression of PIR mRNA
CTD
PMID:25596134
NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
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Plec
plectin
increases expression
ISO
adefovir dipivoxil results in increased expression of PLEC mRNA
CTD
PMID:25596134
NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PMAIP1 mRNA
CTD
PMID:25596134
NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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Pparg
peroxisome proliferator-activated receptor gamma
affects activity
ISO
adefovir dipivoxil affects the activity of PPARG protein
CTD
PMID:25596134
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppm1d
protein phosphatase, Mg2+/Mn2+ dependent, 1D
increases expression
ISO
adefovir dipivoxil results in increased expression of PPM1D mRNA
CTD
PMID:25596134
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
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Prc1
protein regulator of cytokinesis 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PRC1 mRNA
CTD
PMID:25596134
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
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Prdm1
PR/SET domain 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PRDM1 mRNA
CTD
PMID:25596134
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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Prkab2
protein kinase AMP-activated non-catalytic subunit beta 2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PRKAB2 mRNA
CTD
PMID:25596134
NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872
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Psat1
phosphoserine aminotransferase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PSAT1 mRNA
CTD
PMID:25596134
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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Rara
retinoic acid receptor, alpha
decreases expression
ISO
adefovir dipivoxil results in decreased expression of RARA mRNA
CTD
PMID:25596134
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Rps27l
ribosomal protein S27-like
increases expression
ISO
adefovir dipivoxil results in increased expression of RPS27L mRNA
CTD
PMID:25596134
NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418
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Rrm2b
ribonucleotide reductase regulatory TP53 inducible subunit M2B
increases expression
ISO
adefovir dipivoxil results in increased expression of RRM2B mRNA
CTD
PMID:25596134
NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
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Serpinb5
serpin family B member 5
increases expression
ISO
adefovir dipivoxil results in increased expression of SERPINB5 mRNA
CTD
PMID:25596134
NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
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Sesn1
sestrin 1
increases expression
ISO
adefovir dipivoxil results in increased expression of SESN1 mRNA
CTD
PMID:25596134
NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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Sfn
stratifin
increases expression
ISO
adefovir dipivoxil results in increased expression of SFN mRNA
CTD
PMID:25596134
NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
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Sh3tc1
SH3 domain and tetratricopeptide repeats 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SH3TC1 mRNA
CTD
PMID:25596134
NCBI chr14:75,005,691...75,050,001
Ensembl chr14:75,016,875...75,049,995
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Slc27a2
solute carrier family 27 member 2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SLC27A2 mRNA
CTD
PMID:25596134
NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
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Slc6a9
solute carrier family 6 member 9
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SLC6A9 mRNA
CTD
PMID:25596134
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
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Slco2b1
solute carrier organic anion transporter family, member 2b1
increases expression
ISO
adefovir dipivoxil results in increased expression of SLCO2B1 mRNA
CTD
PMID:25596134
NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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Smap1
small ArfGAP 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SMAP1 mRNA
CTD
PMID:25596134
NCBI chr 9:26,250,178...26,342,151
Ensembl chr 9:26,249,978...26,342,170
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Sulf2
sulfatase 2
increases expression
ISO
adefovir dipivoxil results in increased expression of SULF2 mRNA
CTD
PMID:25596134
NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
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Thra
thyroid hormone receptor alpha
multiple interactions
ISO
adefovir dipivoxil binds to and results in decreased activity of THRA protein
CTD
PMID:25752796
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Tigar
TP53 induced glycolysis regulatory phosphatase
increases expression
ISO
adefovir dipivoxil results in increased expression of TIGAR mRNA
CTD
PMID:25596134
NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
increases expression
ISO
adefovir dipivoxil results in increased expression of TIPARP mRNA
CTD
PMID:25596134
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
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Tnfsf9
TNF superfamily member 9
increases expression
ISO
adefovir dipivoxil results in increased expression of TNFSF9 mRNA
CTD
PMID:25596134
NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345
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Tp53
tumor protein p53
affects activity
ISO
adefovir dipivoxil affects the activity of TP53 protein
CTD
PMID:25596134 PMID:35435491
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53inp1
tumor protein p53 inducible nuclear protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of TP53INP1 mRNA
CTD
PMID:25596134
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
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Trafd1
TRAF type zinc finger domain containing 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of TRAFD1 mRNA
CTD
PMID:25596134
NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525
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Triap1
TP53 regulated inhibitor of apoptosis 1
increases expression
ISO
adefovir dipivoxil results in increased expression of TRIAP1 mRNA
CTD
PMID:25596134
NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042
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Ube2o
ubiquitin-conjugating enzyme E2O
decreases expression
ISO
adefovir dipivoxil results in decreased expression of UBE2O mRNA
CTD
PMID:25596134
NCBI chr10:101,765,572...101,812,736
Ensembl chr10:101,766,005...101,812,899
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Yars1
tyrosyl-tRNA synthetase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of YARS1 mRNA
CTD
PMID:25596134
NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
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Zmat3
zinc finger, matrin type 3
increases expression
ISO
adefovir dipivoxil results in increased expression of ZMAT3 mRNA
CTD
PMID:25596134
NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863
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Bglap
bone gamma-carboxyglutamate protein
decreases expression
ISO
Calcium Carbonate results in decreased expression of BGLAP protein
CTD
PMID:2027271
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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Capn1
calpain 1
increases activity
ISO
Calcium Carbonate analog results in increased activity of CAPN1 protein
CTD
PMID:24412303
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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Casp3
caspase 3
increases activity
ISO
Calcium Carbonate analog results in increased activity of CASP3 protein
CTD
PMID:24412303
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Calcium Carbonate analog results in increased expression of DDIT3
CTD
PMID:24412303
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Pth
parathyroid hormone
affects expression decreases expression
ISO
Calcium Carbonate affects the expression of PTH protein Calcium Carbonate results in decreased expression of PTH protein
CTD
PMID:1752077 PMID:2027271 PMID:3826069 PMID:7891547 PMID:8481062 PMID:16006300 More...
NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
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Pthlh
parathyroid hormone-like hormone
decreases expression
ISO
Calcium Carbonate results in decreased expression of PTHLH protein
CTD
PMID:16006300
NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
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Spp1
secreted phosphoprotein 1
decreases expression
ISO
Calcium Carbonate results in decreased expression of SPP1 protein
CTD
PMID:17977878
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Alad
aminolevulinate dehydratase
multiple interactions decreases activity
EXP
Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of ALAD protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of ALAD protein]; Zinc Sulfate inhibits the reaction [Lithium Carbonate results in decreased activity of ALAD protein]
CTD
PMID:19083387 PMID:28988373
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Casp1
caspase 1
increases expression
ISO
Lithium Carbonate results in increased expression of CASP1 protein
CTD
PMID:34984798
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
increases activity multiple interactions increases expression
EXP ISO
Lithium Carbonate results in increased activity of CASP3 protein Butylated Hydroxytoluene inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein] Lithium Carbonate results in increased expression of CASP3 protein
CTD
PMID:27588890 PMID:34984798
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp6
caspase 6
increases expression
ISO
Lithium Carbonate results in increased expression of CASP6 protein
CTD
PMID:34984798
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp7
caspase 7
increases expression
ISO
Lithium Carbonate results in increased expression of CASP7 protein
CTD
PMID:34984798
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
increases expression
ISO
Lithium Carbonate results in increased expression of CASP9 protein
CTD
PMID:34984798
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
decreases activity multiple interactions
EXP ISO
Lithium Carbonate results in decreased activity of CAT protein Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of CAT protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of CAT protein]
CTD
PMID:28988373 PMID:34984798
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Gsr
glutathione-disulfide reductase
multiple interactions decreases activity
EXP
Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of GSR protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of GSR protein]
CTD
PMID:28988373
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Ifng
interferon gamma
multiple interactions
ISO
[Lithium Carbonate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
CTD
PMID:29594315
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il1b
interleukin 1 beta
decreases expression increases expression
ISO
Lithium Carbonate results in decreased expression of IL1B mRNA Lithium Carbonate results in increased expression of IL1B mRNA; Lithium Carbonate results in increased expression of IL1B protein
CTD
PMID:29594315 PMID:34984798
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
multiple interactions
ISO
[Lithium Carbonate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:29594315
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Ins1
insulin 1
decreases expression multiple interactions
EXP
Lithium Carbonate results in decreased expression of INS1 protein Lithium Carbonate inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
CTD
PMID:10700396
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Nfkbia
NFKB inhibitor alpha
increases phosphorylation
ISO
Lithium Carbonate results in increased phosphorylation of NFKBIA protein
CTD
PMID:34984798
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nlrp3
NLR family, pyrin domain containing 3
increases expression
ISO
Lithium Carbonate results in increased expression of NLRP3 protein
CTD
PMID:34984798
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Pfkfb2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
decreases activity multiple interactions
EXP
Lithium Carbonate results in decreased activity of PFKFB2 protein Lithium Carbonate inhibits the reaction [Streptozocin results in decreased activity of PFKFB2 protein]
CTD
PMID:10700396
NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699
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Pla2g4a
phospholipase A2 group 4A
increases expression
ISO
Lithium Carbonate results in increased expression of PLA2G4A mRNA; Lithium Carbonate results in increased expression of PLA2G4A protein
CTD
PMID:17594078
NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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Pth
parathyroid hormone
increases expression
ISO
Lithium Carbonate results in increased expression of PTH protein
CTD
PMID:3083797 PMID:18234408
NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
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Pycard
PYD and CARD domain containing
increases expression
ISO
Lithium Carbonate results in increased expression of PYCARD protein
CTD
PMID:34984798
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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Rela
RELA proto-oncogene, NF-kB subunit
increases phosphorylation
ISO
Lithium Carbonate results in increased phosphorylation of RELA protein
CTD
PMID:34984798
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Tnf
tumor necrosis factor
increases expression
ISO
Lithium Carbonate results in increased expression of TNF mRNA; Lithium Carbonate results in increased expression of TNF protein
CTD
PMID:34984798
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Ar
androgen receptor
multiple interactions
ISO
Loteprednol Etabonate binds to and results in decreased activity of AR protein; Loteprednol Etabonate binds to and results in increased activity of AR protein
CTD
PMID:25752796
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Pgr
progesterone receptor
multiple interactions
ISO
Loteprednol Etabonate binds to and results in increased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Foxo1
forkhead box O1
increases expression
ISO
spirotetramat results in increased expression of FOXO1 mRNA
CTD
PMID:27917277
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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Vnn1
vanin 1
decreases expression
ISO
spirotetramat results in decreased expression of VNN1 mRNA
CTD
PMID:27917277
NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
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