|
|
| G
|
Akt1
|
AKT serine/threonine kinase 1
|
multiple interactions increases expression
|
EXP
|
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of AKT1 protein]
|
CTD |
PMID:37661366 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
| G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions increases expression
|
EXP
|
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of BCL2 protein]
|
CTD |
PMID:37661366 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
| G
|
Bdnf
|
brain-derived neurotrophic factor
|
multiple interactions
|
EXP
|
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein]
|
CTD |
PMID:24718106 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
|
|
| G
|
Calca
|
calcitonin-related polypeptide alpha
|
multiple interactions increases secretion
|
EXP
|
Carbon Dioxide inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]; Carbon Dioxide inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Carbon Dioxide inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased secretion of CALCA protein] Carbon Dioxide results in increased secretion of CALCA protein
|
CTD |
PMID:18052948 |
|
NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
|
|
| G
|
Camk2b
|
calcium/calmodulin-dependent protein kinase II beta
|
multiple interactions
|
EXP
|
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein]
|
CTD |
PMID:24718106 |
|
NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485
|
|
| G
|
Creb1
|
cAMP responsive element binding protein 1
|
multiple interactions
|
EXP
|
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein]
|
CTD |
PMID:24718106 |
|
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
|
|
| G
|
Crh
|
corticotropin releasing hormone
|
increases response to substance
|
ISO
|
CRH protein results in increased susceptibility to Carbon Dioxide
|
CTD |
PMID:8957205 |
|
NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
|
|
| G
|
Dlg3
|
discs large MAGUK scaffold protein 3
|
multiple interactions
|
EXP
|
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein]
|
CTD |
PMID:24718106 |
|
NCBI chr X:69,899,694...69,951,928
Ensembl chr X:69,900,003...69,950,696
|
|
| G
|
Grin2b
|
glutamate ionotropic receptor NMDA type subunit 2B
|
multiple interactions
|
EXP
|
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein]
|
CTD |
PMID:24718106 |
|
NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570
|
|
| G
|
Il2
|
interleukin 2
|
multiple interactions increases expression
|
EXP ISO
|
3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of IL2 mRNA]; 3-n-butylphthalide promotes the reaction [Carbon Dioxide results in increased expression of IL2 protein] Carbon Dioxide results in increased expression of IL2 mRNA; Carbon Dioxide results in increased expression of IL2 protein
|
CTD |
PMID:37661366 |
|
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
|
|
| G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions
|
EXP
|
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:24718106 PMID:25004876 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
| G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions
|
EXP
|
[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK3 mRNA; [Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK3 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK3 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:24718106 PMID:25004876 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
| G
|
Mir29a
|
microRNA 29a
|
multiple interactions
|
ISO
|
[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Dioxide] which results in increased expression of MIR29A mRNA
|
CTD |
PMID:29980036 |
|
NCBI chr 4:60,617,955...60,618,042
|
|
| G
|
Neil1
|
nei-like DNA glycosylase 1
|
affects abundance
|
ISO
|
NEIL1 affects the abundance of Carbon Dioxide
|
CTD |
PMID:21285402 |
|
NCBI chr 8:66,446,106...66,452,844
Ensembl chr 8:66,445,953...66,452,378
|
|
| G
|
Ngb
|
neuroglobin
|
affects binding
|
ISO
|
Carbon Dioxide binds to [Heme binds to NGB protein]
|
CTD |
PMID:16684569 |
|
NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:112,475,332...112,480,786
|
|
| G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
multiple interactions
|
ISO
|
PPARA protein promotes the reaction [[GW 7647 results in increased oxidation of Palmitic Acid] which results in increased abundance of Carbon Dioxide]
|
CTD |
PMID:21324916 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
|
|
| G
|
Rapgef3
|
Rap guanine nucleotide exchange factor 3
|
multiple interactions
|
ISO
|
[RAPGEF3 protein affects the susceptibility to Dietary Fats] which affects the chemical synthesis of Carbon Dioxide
|
CTD |
PMID:27381457 |
|
NCBI chr 7:130,754,883...130,777,303
Ensembl chr 7:130,754,871...130,777,668
|
|
| G
|
Slc9a1
|
solute carrier family 9 member A1
|
affects response to substance
|
EXP
|
SLC9A1 protein affects the susceptibility to Carbon Dioxide
|
CTD |
PMID:16831598 |
|
NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517
|
|
| G
|
Sod1
|
superoxide dismutase 1
|
multiple interactions
|
ISO
|
[[[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid] which results in increased chemical synthesis of Carbonates; [[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid; [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide]] which results in increased chemical synthesis of Carbonates; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein results in increased metabolism of Hydrogen Peroxide]; [SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide]
|
CTD |
PMID:19243126 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
|
|
| G
|
Syncrip
|
synaptotagmin binding, cytoplasmic RNA interacting protein
|
multiple interactions
|
ISO
|
[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Dioxide] which affects the expression of SYNCRIP mRNA
|
CTD |
PMID:29980036 |
|
NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:98,282,358...98,315,386
|
|
| G
|
Syngap1
|
synaptic Ras GTPase activating protein 1
|
multiple interactions
|
EXP
|
[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein; ifenprodil inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein]
|
CTD |
PMID:24718106 |
|
NCBI chr20:5,028,226...5,058,519
Ensembl chr20:5,026,707...5,057,751
|
|
| G
|
Tpi1
|
triosephosphate isomerase 1
|
increases expression
|
EXP
|
Carbon Dioxide results in increased expression of TPI1 mRNA
|
CTD |
PMID:14762718 |
|
NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413
|
|
| G
|
Trh
|
thyrotropin releasing hormone
|
increases response to substance
|
ISO
|
TRH protein results in increased susceptibility to Carbon Dioxide
|
CTD |
PMID:8957205 |
|
NCBI chr 4:126,299,236...126,301,762
Ensembl chr 4:126,299,236...126,301,762
|
|
| G
|
Trpa1
|
transient receptor potential cation channel, subfamily A, member 1
|
increases activity
|
EXP
|
Carbon Dioxide results in increased activity of TRPA1 protein
|
CTD |
PMID:20881114 |
|
NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325
|
|
| G
|
Trpv1
|
transient receptor potential cation channel, subfamily V, member 1
|
affects response to substance
|
EXP
|
TRPV1 protein affects the susceptibility to Carbon Dioxide
|
CTD |
PMID:16831598 |
|
NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021
|
|
|
|
| G
|
Abcc2
|
ATP binding cassette subfamily C member 2
|
increases activity
|
EXP
|
Carbon Monoxide results in increased activity of ABCC2 protein
|
CTD |
PMID:13678533 |
|
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
|
|
| G
|
Adipoq
|
adiponectin, C1Q and collagen domain containing
|
multiple interactions increases expression
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein; Carbon Monoxide results in increased expression of ADIPOQ protein
|
CTD |
PMID:19356108 |
|
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
|
|
| G
|
Adm
|
adrenomedullin
|
increases expression
|
EXP
|
Carbon Monoxide results in increased expression of ADM mRNA; Carbon Monoxide results in increased expression of ADM protein
|
CTD |
PMID:10666155 |
|
NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371
|
|
| G
|
Agr2
|
anterior gradient 2, protein disulphide isomerase family member
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of AGR2 mRNA
|
CTD |
PMID:29621558 |
|
NCBI chr 6:58,435,908...58,456,678
Ensembl chr 6:58,435,908...58,456,677
|
|
| G
|
Agt
|
angiotensinogen
|
decreases response to substance
|
ISO
|
AGT protein results in decreased susceptibility to Carbon Monoxide
|
CTD |
PMID:18174886 |
|
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
|
|
| G
|
Akt1
|
AKT serine/threonine kinase 1
|
multiple interactions increases phosphorylation
|
ISO EXP
|
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein] Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]
|
CTD |
PMID:17179207 PMID:18037988 PMID:18215737 PMID:18845810 PMID:19356108 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
| G
|
Alad
|
aminolevulinate dehydratase
|
increases activity multiple interactions
|
EXP
|
Carbon Monoxide results in increased activity of ALAD protein Carbon Monoxide inhibits the reaction [[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein]
|
CTD |
PMID:1032310 PMID:6740708 |
|
NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041
|
|
| G
|
Areg
|
amphiregulin
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of AREG mRNA
|
CTD |
PMID:29621558 |
|
NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641
|
|
| G
|
Bach1
|
BTB domain and CNC homolog 1
|
decreases phosphorylation
|
ISO
|
Carbon Monoxide results in decreased phosphorylation of BACH1 protein
|
CTD |
PMID:18845810 |
|
NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277
|
|
| G
|
Bad
|
BCL2-associated agonist of cell death
|
multiple interactions
|
ISO
|
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein]
|
CTD |
PMID:18037988 |
|
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
|
|
| G
|
Bcl2a1
|
BCL2-related protein A1
|
multiple interactions
|
ISO
|
BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]
|
CTD |
PMID:11880364 |
|
NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890
|
|
| G
|
Bdnf
|
brain-derived neurotrophic factor
|
multiple interactions decreases expression
|
EXP
|
Carbon Monoxide results in decreased expression of and results in decreased secretion of BDNF protein Carbon Monoxide results in decreased expression of BDNF mRNA
|
CTD |
PMID:27113706 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
|
|
| G
|
Birc3
|
baculoviral IAP repeat-containing 3
|
multiple interactions
|
ISO
|
BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]
|
CTD |
PMID:11880364 |
|
NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590
|
|
| G
|
Casp3
|
caspase 3
|
multiple interactions increases activity increases expression
|
EXP ISO
|
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP3 mRNA]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]] Carbon Monoxide results in increased activity of CASP3 protein [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP3 mRNA Carbon Monoxide results in increased expression of CASP3 protein
|
CTD |
PMID:17173083 PMID:19356108 PMID:19520142 PMID:25562542 PMID:31268311 PMID:37860845 More...
|
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
| G
|
Casp7
|
caspase 7
|
increases activity
|
EXP
|
Carbon Monoxide results in increased activity of CASP7 protein
|
CTD |
PMID:25562542 |
|
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512
|
|
| G
|
Casp8
|
caspase 8
|
increases activity multiple interactions
|
EXP ISO
|
Carbon Monoxide results in increased activity of CASP8 protein [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA
|
CTD |
PMID:25562542 PMID:31268311 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
|
|
| G
|
Casp9
|
caspase 9
|
increases activity multiple interactions increases expression
|
EXP ISO
|
Carbon Monoxide results in increased activity of CASP9 protein [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP9 mRNA Carbon Monoxide results in increased expression of CASP9 mRNA; Carbon Monoxide results in increased expression of CASP9 protein sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP9 mRNA]; sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP9 protein]
|
CTD |
PMID:25562542 PMID:31268311 PMID:37860845 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
| G
|
Cat
|
catalase
|
multiple interactions decreases expression
|
ISO EXP
|
CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein] CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; NFE2L2 protein inhibits the reaction [Carbon Monoxide results in decreased expression of CAT protein]
|
CTD |
PMID:17179207 PMID:18845810 PMID:34032369 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
| G
|
Ccl1
|
C-C motif chemokine ligand 1
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of CCL1 mRNA
|
CTD |
PMID:29621558 |
|
NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,625,962...67,628,790
|
|
| G
|
Cd86
|
CD86 molecule
|
decreases expression
|
EXP
|
Carbon Monoxide results in decreased expression of CD86 protein
|
CTD |
PMID:12201358 |
|
NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361
|
|
| G
|
Clca1
|
chloride channel accessory 1
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CLCA1 mRNA
|
CTD |
PMID:29621558 |
|
NCBI chr 2:236,599,022...236,624,714
Ensembl chr 2:236,599,022...236,624,714
|
|
| G
|
Col11a1
|
collagen type XI alpha 1 chain
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of COL11A1 mRNA
|
CTD |
PMID:29621558 |
|
NCBI chr 2:204,509,136...204,702,264
Ensembl chr 2:204,509,136...204,702,264
|
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| G
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Crp
|
C-reactive protein
|
increases expression
|
ISO
|
Carbon Monoxide results in increased expression of CRP protein
|
CTD |
PMID:18629312 |
|
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514
|
|
| G
|
Cxcl11
|
C-X-C motif chemokine ligand 11
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CXCL11 mRNA
|
CTD |
PMID:29621558 |
|
NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567
|
|
| G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
multiple interactions
|
EXP
|
Carbon Monoxide inhibits the reaction [CYP1A1 protein results in increased reduction of sodium chromate(VI)]
|
CTD |
PMID:1903091 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
|
|
| G
|
Cyp1b1
|
cytochrome P450, family 1, subfamily b, polypeptide 1
|
multiple interactions
|
ISO
|
Carbon Monoxide promotes the reaction [1-ethynylpyrene results in increased expression of CYP1B1 mRNA]
|
CTD |
PMID:10581206 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
|
|
| G
|
Cyp2b1
|
cytochrome P450, family 2, subfamily b, polypeptide 1
|
multiple interactions
|
EXP
|
Carbon Monoxide inhibits the reaction [CYP2B1 protein results in increased reduction of sodium chromate(VI)]
|
CTD |
PMID:1903091 |
|
NCBI chr 1:90,646,098...90,669,762
|
|
| G
|
Cyp2e1
|
cytochrome P450, family 2, subfamily e, polypeptide 1
|
decreases activity multiple interactions
|
ISO EXP
|
Carbon Monoxide results in decreased activity of CYP2E1 protein Carbon Monoxide inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)]
|
CTD |
PMID:1903091 PMID:15036350 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
|
|
| G
|
Dnm1l
|
dynamin 1-like
|
multiple interactions increases expression
|
EXP
|
sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of DNM1L protein]
|
CTD |
PMID:37860845 |
|
NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420
|
|
| G
|
Duox2
|
dual oxidase 2
|
increases expression decreases expression
|
EXP
|
Carbon Monoxide results in increased expression of DUOX2 mRNA Carbon Monoxide results in decreased expression of DUOX2 protein
|
CTD |
PMID:29223502 |
|
NCBI chr 3:129,680,543...129,698,886
Ensembl chr 3:129,680,546...129,699,203
|
|
| G
|
Edn1
|
endothelin 1
|
increases expression multiple interactions
|
EXP ISO
|
Carbon Monoxide results in increased expression of EDN1 mRNA; Carbon Monoxide results in increased expression of EDN1 protein Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]
|
CTD |
PMID:11781074 PMID:12969895 PMID:20197249 |
|
NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687
|
|
| G
|
Egr1
|
early growth response 1
|
multiple interactions
|
ISO
|
Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA]; Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]; UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]
|
CTD |
PMID:22046279 |
|
NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843
|
|
| G
|
Eno2
|
enolase 2
|
increases secretion
|
ISO
|
Carbon Monoxide results in increased secretion of ENO2 protein
|
CTD |
PMID:34533065 |
|
NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220
|
|
| G
|
Epo
|
erythropoietin
|
increases expression
|
EXP
|
Carbon Monoxide results in increased expression of EPO mRNA; Carbon Monoxide results in increased expression of EPO protein
|
CTD |
PMID:9263988 |
|
NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725
|
|
| G
|
Ero1a
|
endoplasmic reticulum oxidoreductase 1 alpha
|
increases expression
|
EXP
|
Carbon Monoxide results in increased expression of ERO1A mRNA
|
CTD |
PMID:12752442 |
|
NCBI chr15:20,974,771...21,010,170
Ensembl chr15:20,972,679...21,018,039
|
|
| G
|
Ezr
|
ezrin
|
multiple interactions
|
ISO
|
[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Monoxide] which results in decreased expression of EZR protein
|
CTD |
PMID:37141245 |
|
NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573
|
|
| G
|
Fgb
|
fibrinogen beta chain
|
multiple interactions
|
ISO
|
FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]
|
CTD |
PMID:19750100 |
|
NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:170,692,965...170,705,434
|
|
| G
|
Foxp3
|
forkhead box P3
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of FOXP3 gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of FOXP3 promoter
|
CTD |
PMID:29317916 PMID:33603036 |
|
NCBI chr X:17,580,380...17,601,181
Ensembl chr X:17,580,380...17,595,894
|
|
| G
|
Gabpa
|
GA binding protein transcription factor subunit alpha
|
increases expression multiple interactions
|
ISO EXP
|
Carbon Monoxide results in increased expression of GABPA mRNA 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]
|
CTD |
PMID:17179207 |
|
NCBI chr11:37,375,040...37,404,060
Ensembl chr11:37,375,084...37,404,059
|
|
| G
|
Gata4
|
GATA binding protein 4
|
multiple interactions
|
ISO
|
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased activity of GATA4 protein]
|
CTD |
PMID:18037988 |
|
NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609
|
|
| G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
increases expression multiple interactions
|
EXP
|
Carbon Monoxide results in increased expression of GCLC mRNA [NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA
|
CTD |
PMID:34032369 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
|
|
| G
|
Gpr182
|
G protein-coupled receptor 182
|
increases expression
|
EXP
|
Carbon Monoxide results in increased expression of GPR182 mRNA
|
CTD |
PMID:10666155 |
|
NCBI chr 7:65,471,254...65,474,110
Ensembl chr 7:65,452,965...65,474,998
|
|
| G
|
Gpx4
|
glutathione peroxidase 4
|
multiple interactions
|
ISO
|
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]
|
CTD |
PMID:18037988 |
|
NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
|
|
| G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
multiple interactions increases phosphorylation
|
ISO
|
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein] Carbon Monoxide results in increased phosphorylation of GSK3B protein
|
CTD |
PMID:18037988 PMID:18845810 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
|
|
| G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions increases activity increases expression increases chemical synthesis
|
ISO EXP
|
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]; HMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA] Edaravone promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased activity of HMOX1 protein] [HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
|
CTD |
PMID:11880364 PMID:16365149 PMID:18037988 PMID:18845810 PMID:19520142 PMID:21444764 PMID:25348283 PMID:29165873 More...
|
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
|
|
| G
|
Hmox2
|
heme oxygenase 2
|
multiple interactions affects abundance affects chemical synthesis
|
EXP
|
Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein] HMOX2 protein affects the abundance of Carbon Monoxide HMOX2 protein affects the chemical synthesis of Carbon Monoxide
|
CTD |
PMID:11342580 PMID:12969895 |
|
NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800
|
|
| G
|
Icam1
|
intercellular adhesion molecule 1
|
multiple interactions
|
EXP ISO
|
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
|
CTD |
PMID:19356108 PMID:19608869 |
|
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
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|
| G
|
Ifng
|
interferon gamma
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IFNG protein; Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein] [Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IFNG gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of IFNG gene
|
CTD |
PMID:16365149 PMID:29621558 PMID:33603036 PMID:35287715 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
|
|
| G
|
Igf2bp1
|
insulin-like growth factor 2 mRNA binding protein 1
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IGF2BP1 gene
|
CTD |
PMID:35999615 |
|
NCBI chr10:81,405,021...81,447,814
Ensembl chr10:81,404,797...81,447,846
|
|
| G
|
Il10
|
interleukin 10
|
multiple interactions increases expression
|
ISO EXP
|
Carbon Monoxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein] Carbon Monoxide results in increased expression of IL10 mRNA Carbon Monoxide results in increased expression of IL10 protein (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]] [Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IL10 gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of IL10 gene
|
CTD |
PMID:21444764 PMID:31732924 PMID:33603036 PMID:35287715 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
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|
| G
|
Il12b
|
interleukin 12B
|
multiple interactions
|
ISO
|
Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]
|
CTD |
PMID:16365149 |
|
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
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|
| G
|
Il13
|
interleukin 13
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IL13 mRNA
|
CTD |
PMID:29621558 |
|
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
|
|
| G
|
Il17a
|
interleukin 17A
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL17A protein
|
CTD |
PMID:29621558 |
|
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
|
|
| G
|
Il18
|
interleukin 18
|
decreases response to substance multiple interactions
|
ISO
|
Carbon Monoxide results in decreased susceptibility to IL18 protein Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
|
CTD |
PMID:18215737 |
|
NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
|
|
| G
|
Il1b
|
interleukin 1 beta
|
decreases expression increases expression multiple interactions
|
ISO EXP
|
Carbon Monoxide results in decreased expression of IL1B protein Carbon Monoxide results in increased expression of IL1B protein (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]]
|
CTD |
PMID:21444764 PMID:31732924 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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|
| G
|
Il1rl1
|
interleukin 1 receptor-like 1
|
increases expression multiple interactions
|
EXP
|
Carbon Monoxide results in increased expression of IL1RL1 protein (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]]
|
CTD |
PMID:31732924 |
|
NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891
|
|
| G
|
Il33
|
interleukin 33
|
multiple interactions increases expression
|
EXP
|
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]; AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]]
|
CTD |
PMID:31732924 |
|
NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901
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|
| G
|
Il4
|
interleukin 4
|
decreases expression multiple interactions
|
ISO EXP
|
Carbon Monoxide results in decreased expression of IL4 protein [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL4 protein [Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein; iodopravadoline inhibits the reaction [[Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein] [Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IL4 gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of IL4 gene
|
CTD |
PMID:21444764 PMID:29621558 PMID:31732924 PMID:33603036 PMID:35287715 |
|
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
|
|
| G
|
Il6
|
interleukin 6
|
multiple interactions increases expression
|
ISO
|
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of IL6 protein; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]; IL6 gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]
|
CTD |
PMID:18629312 PMID:19608869 PMID:19750100 PMID:31268311 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
| G
|
Irf8
|
interferon regulatory factor 8
|
decreases activity
|
ISO
|
Carbon Monoxide results in decreased activity of IRF8 protein
|
CTD |
PMID:16365149 |
|
NCBI chr19:65,699,284...65,721,066
Ensembl chr19:65,699,284...65,721,062
|
|
| G
|
Keap1
|
Kelch-like ECH-associated protein 1
|
multiple interactions
|
ISO
|
Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]
|
CTD |
PMID:18845810 |
|
NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042
|
|
| G
|
Mapk14
|
mitogen activated protein kinase 14
|
multiple interactions
|
ISO
|
MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]
|
CTD |
PMID:11880364 |
|
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
|
|
| G
|
Mbp
|
myelin basic protein
|
affects response to substance
|
ISO
|
MBP polymorphism affects the susceptibility to Carbon Monoxide
|
CTD |
PMID:36481359 |
|
NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174
|
|
| G
|
Mfn2
|
mitofusin 2
|
multiple interactions decreases expression
|
EXP
|
sulforaphane affects the reaction [Carbon Monoxide results in decreased expression of MFN2 protein]; sulforaphane inhibits the reaction [Carbon Monoxide results in decreased expression of MFN2 mRNA] Carbon Monoxide results in decreased expression of MFN2 mRNA; Carbon Monoxide results in decreased expression of MFN2 protein
|
CTD |
PMID:37860845 |
|
NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495
|
|
| G
|
Mir1224
|
microRNA 1224
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR1224 mRNA
|
CTD |
PMID:31268311 |
|
NCBI chr11:93,811,291...93,811,375
|
|
| G
|
Mir186
|
microRNA 186
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR186 mRNA
|
CTD |
PMID:31268311 |
|
NCBI chr 2:249,241,650...249,241,735
Ensembl chr 2:249,241,650...249,241,735
|
|
| G
|
Mir21
|
microRNA 21
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR21 mRNA
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CTD |
PMID:31268311 |
|
NCBI chr10:71,902,600...71,902,691
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| G
|
Mir342
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microRNA 342
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multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR342 mRNA
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CTD |
PMID:31268311 |
|
NCBI chr 6:133,329,655...133,329,753
Ensembl chr 6:133,329,655...133,329,753
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|
| G
|
Mir374b
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microRNA 374b
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multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR374B mRNA
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CTD |
PMID:31268311 |
|
NCBI chr X:72,657,495...72,657,562
|
|
| G
|
Mir615
|
microRNA 615
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multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR615 mRNA
|
CTD |
PMID:31268311 |
|
NCBI chr 7:136,030,353...136,030,444
Ensembl chr 7:136,030,353...136,030,444
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|
| G
|
Mir93
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microRNA 93
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multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR93 mRNA
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CTD |
PMID:31268311 |
|
NCBI chr12:22,156,844...22,156,930
|
|
| G
|
Mirlet7i
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microRNA let-7i
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multiple interactions
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ISO
|
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7I mRNA
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CTD |
PMID:31268311 |
|
NCBI chr 7:60,527,877...60,527,961
|
|
| G
|
Mmp9
|
matrix metallopeptidase 9
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increases expression
|
ISO
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Carbon Monoxide results in increased expression of MMP9 mRNA
|
CTD |
PMID:20197249 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
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|
| G
|
Mrc1
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mannose receptor, C type 1
|
multiple interactions
|
EXP
|
[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein; iodopravadoline inhibits the reaction [[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein]
|
CTD |
PMID:31732924 |
|
NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410
|
|
| G
|
Ndrg1
|
N-myc downstream regulated 1
|
multiple interactions
|
ISO
|
Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 mRNA]; Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 protein]
|
CTD |
PMID:11006124 |
|
NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:100,573,523...100,614,913
|
|
| G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
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multiple interactions decreases phosphorylation increases expression increases localization
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ISO EXP
|
Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]; CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA] Carbon Monoxide results in decreased phosphorylation of NFE2L2 protein Carbon Monoxide results in increased expression of NFE2L2 mRNA [NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA; Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [Carbon Monoxide results in decreased expression of CAT protein]; NFE2L2 protein promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 mRNA] Carbon Monoxide results in increased expression of NFE2L2 mRNA; Carbon Monoxide results in increased expression of NFE2L2 protein
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CTD |
PMID:18845810 PMID:25348283 PMID:34032369 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
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|
| G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
[RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
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CTD |
PMID:11880364 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
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|
| G
|
Ngf
|
nerve growth factor
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affects expression multiple interactions
|
EXP
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Carbon Monoxide affects the expression of NGF mRNA Carbon Monoxide results in decreased expression of and affects the secretion of NGF protein
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CTD |
PMID:27113706 |
|
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
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|
| G
|
Nos2
|
nitric oxide synthase 2
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multiple interactions decreases expression
|
ISO EXP
|
Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] Carbon Monoxide results in decreased expression of NOS2 protein
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CTD |
PMID:12201358 PMID:22046279 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
| G
|
Nos3
|
nitric oxide synthase 3
|
multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein
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CTD |
PMID:19356108 |
|
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
|
|
| G
|
Nppa
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natriuretic peptide A
|
increases expression
|
EXP
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Carbon Monoxide results in increased expression of NPPA mRNA
|
CTD |
PMID:11781074 |
|
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493
|
|
| G
|
Nrf1
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nuclear respiratory factor 1
|
multiple interactions increases expression increases localization
|
ISO EXP
|
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter] Carbon Monoxide results in increased expression of NRF1 mRNA 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
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CTD |
PMID:17179207 PMID:18845810 |
|
NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353
|
|
| G
|
Ntf3
|
neurotrophin 3
|
decreases expression multiple interactions
|
EXP
|
Carbon Monoxide results in decreased expression of NTF3 mRNA Carbon Monoxide results in decreased expression of and results in decreased secretion of NTF3 protein
|
CTD |
PMID:27113706 |
|
NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:160,600,770...160,676,349
|
|
| G
|
Pecam1
|
platelet and endothelial cell adhesion molecule 1
|
increases expression
|
EXP
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[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein
|
CTD |
PMID:19356108 |
|
NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839
|
|
| G
|
Pla2g7
|
phospholipase A2 group VII
|
affects expression
|
ISO
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Carbon Monoxide affects the expression of PLA2G7
|
CTD |
PMID:21356620 |
|
NCBI chr 9:24,859,491...24,901,747
Ensembl chr 9:24,859,502...24,901,747
|
|
| G
|
Polg
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DNA polymerase gamma, catalytic subunit
|
increases expression
|
ISO
|
Carbon Monoxide results in increased expression of POLG mRNA; Carbon Monoxide results in increased expression of POLG protein
|
CTD |
PMID:17179207 |
|
NCBI chr 1:142,792,119...142,808,933
Ensembl chr 1:142,792,119...142,808,838
|
|
| G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions
|
ISO
|
[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein; Acetylcysteine inhibits the reaction [[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
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CTD |
PMID:22046279 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
|
|
| G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
increases expression multiple interactions
|
ISO EXP
|
Carbon Monoxide results in increased expression of PPARGC1A mRNA 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]
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CTD |
PMID:17179207 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
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|
| G
|
Prg2
|
proteoglycan 2, pro eosinophil major basic protein
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of PRG2 mRNA
|
CTD |
PMID:29621558 |
|
NCBI chr 3:90,469,192...90,472,759
Ensembl chr 3:90,469,176...90,472,752
|
|
| G
|
Prkaa2
|
protein kinase AMP-activated catalytic subunit alpha 2
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multiple interactions decreases expression
|
EXP
|
sulforaphane inhibits the reaction [Carbon Monoxide results in decreased expression of PRKAA2 mRNA]
|
CTD |
PMID:37860845 |
|
NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324
|
|
| G
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Pten
|
phosphatase and tensin homolog
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multiple interactions
|
ISO
|
Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
|
CTD |
PMID:18215737 |
|
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
|
|
| G
|
Rel
|
REL proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
[RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
|
CTD |
PMID:11880364 |
|
NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938
|
|
| G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
[RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
|
CTD |
PMID:11880364 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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|
| G
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Selp
|
selectin P
|
increases expression
|
ISO
|
Carbon Monoxide results in increased expression of SELP protein modified form
|
CTD |
PMID:18629312 |
|
NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987
|
|
| G
|
Sftpd
|
surfactant protein D
|
multiple interactions
|
ISO
|
[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Monoxide] which results in increased expression of SFTPD protein
|
CTD |
PMID:37141245 |
|
NCBI chr16:17,080,575...17,093,047
Ensembl chr16:17,080,567...17,094,036
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|
| G
|
Sod1
|
superoxide dismutase 1
|
decreases expression
|
ISO
|
Carbon Monoxide results in decreased expression of SOD1 protein
|
CTD |
PMID:18629312 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
|
|
| G
|
Sod2
|
superoxide dismutase 2
|
multiple interactions increases expression
|
ISO EXP
|
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA] Carbon Monoxide results in increased expression of SOD2 protein
|
CTD |
PMID:17179207 PMID:18037988 PMID:18845810 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
|
|
| G
|
Sostdc1
|
sclerostin domain containing 1
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of SOSTDC1 mRNA
|
CTD |
PMID:29621558 |
|
NCBI chr 6:58,778,623...58,782,797
Ensembl chr 6:58,778,623...58,782,866
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|
| G
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Tfam
|
transcription factor A, mitochondrial
|
increases expression multiple interactions
|
ISO EXP
|
Carbon Monoxide results in increased expression of TFAM mRNA; Carbon Monoxide results in increased expression of TFAM protein 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
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CTD |
PMID:17179207 |
|
NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877
|
|
| G
|
Tnf
|
tumor necrosis factor
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multiple interactions decreases expression decreases response to substance increases expression
|
EXP ISO
|
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]] Carbon Monoxide results in decreased expression of TNF protein [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of TNF protein; [HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] Carbon Monoxide results in decreased susceptibility to TNF protein Carbon monoxide decreases expression of Tnf mRNA in reperfused liver nonparenchymal cells
|
CTD RGD |
PMID:11880364 PMID:17173083 PMID:19356108 PMID:19608869 PMID:21444764 PMID:31268311 PMID:31732924 PMID:18972563 More...
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RGD:15023490 |
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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|
| G
|
Tnfrsf1b
|
TNF receptor superfamily member 1B
|
increases expression
|
ISO
|
Carbon Monoxide results in increased expression of TNFRSF1B protein modified form
|
CTD |
PMID:18629312 |
|
NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411
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|
| G
|
Tnfsf4
|
TNF superfamily member 4
|
multiple interactions
|
ISO
|
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of TNFSF4 mRNA
|
CTD |
PMID:29621558 |
|
NCBI chr13:76,256,654...76,280,133
Ensembl chr13:76,256,654...76,280,133
|
|
| G
|
Ucp2
|
uncoupling protein 2
|
multiple interactions
|
ISO
|
UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]; UCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species]
|
CTD |
PMID:22046279 |
|
NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743
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|
| G
|
Vasp
|
vasodilator-stimulated phosphoprotein
|
decreases phosphorylation
|
ISO
|
Carbon Monoxide results in decreased phosphorylation of VASP protein
|
CTD |
PMID:26582457 |
|
NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650
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|
| G
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Vcam1
|
vascular cell adhesion molecule 1
|
multiple interactions
|
ISO EXP
|
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
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CTD |
PMID:19356108 PMID:19608869 |
|
NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
|
|
| G
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Xdh
|
xanthine dehydrogenase
|
increases activity increases metabolic processing
|
EXP
|
Carbon Monoxide results in increased activity of XDH protein Carbon Monoxide results in increased metabolism of XDH protein
|
CTD |
PMID:1447108 |
|
NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350
|
|